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A laboratory-evolved CRISPR-associated transposase adapts to human cells Nat. Biotechnol. (IF 33.1) Pub Date : 2025-06-16 Iris Marchal
CRISPR-associated transposases (CASTs) are an attractive candidate for genome editing applications, as they enable the insertion of large DNA cargoes without creating double-strand breaks. However, CAST systems have shown limited activity in human cells. In a paper published in Science, Witte et al. apply phage-assisted continuous evolution (PACE) to direct the rapid evolution of new CAST variants
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Infant receives the first customized CRISPR therapy Nat. Biotechnol. (IF 33.1) Pub Date : 2025-06-16 Iris Marchal
Base and prime editors promise to correct nearly all known pathogenic variants, but their therapeutic development is restricted to a handful of recurrent mutations owing to the high cost of bringing gene therapies to market. Writing in the New England Journal of Medicine, Musunuru et al. report on the rapid development of a customized base-editing therapy, provided to an infant born with a rare disease
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CRISPR-TO directs RNA to defined intracellular locations Nat. Biotechnol. (IF 33.1) Pub Date : 2025-06-16 Iris Marchal
Although spatial RNA organization is central to cellular functions and disease mechanisms, its functional consequences remain poorly understood owing to a lack of tools for manipulating RNA localization within cells. Writing in Nature, Han et al. introduce CRISPR-mediated transcriptome organization (CRISPR-TO), a method that uses the RNA-guiding properties of nuclease-dead dCas13 to transport endogenous
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Organoids Nat. Biotechnol. (IF 33.1) Pub Date : 2025-06-16
Recent patents relating to the production, culture and use of organoids.
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People Nat. Biotechnol. (IF 33.1) Pub Date : 2025-06-16
Recent moves of note in and around the biotech and pharma industries.
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Thinking about a move from academia to industry? Look before you leap Nat. Biotechnol. (IF 33.1) Pub Date : 2025-06-16 William N. Hait
To those considering a change in careers from academia to the pharmaceutical industry, here are the keys to a successful transition.
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The New Clinical Investigation exclusivity: a substantial source of monopoly time for brand drugs Nat. Biotechnol. (IF 33.1) Pub Date : 2025-06-16 Robin Feldman, Gideon Schor, Ramy Alsaffar
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England poised to green-light precision breeding Nat. Biotechnol. (IF 33.1) Pub Date : 2025-06-16
The UK government is close to approving rules for precision-bred plants in England. In May, Parliament published draft legislation that will enable a new regulatory system, as set out in the Genetic Technology (Precision Breeding) Act 2023.
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FDA says GM pigs safe to eat Nat. Biotechnol. (IF 33.1) Pub Date : 2025-06-16
Pigs genetically modified to resist a devastating virus are now approved for human consumption in the United States. British animal genetics company Genus, based in Basingstoke, announced in April that the US Food and Drug Administration (FDA) had approved its gene-edited pigs after a lengthy review through the agency’s Investigational New Drug regulatory pathway.
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Biotech news from around the world Nat. Biotechnol. (IF 33.1) Pub Date : 2025-06-16
A new law proposed by the Federal Council would ease restrictions on plants developed through new genomic techniques such as CRISPR. Currently in Switzerland, such plants are treated similarly to those developed through conventional genetic engineering, including an ongoing moratorium on cultivation. If passed, the Breeding Technologies Act would enact a risk-based authorization system that reflects
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Court reignites CRISPR patent dispute Nat. Biotechnol. (IF 33.1) Pub Date : 2025-06-16
The University of California and the University of Vienna have convinced a US appeals court to revive their bid for patent rights to the CRISPR–Cas9 gene-editing technology created by their scientists Jennifer Doudna and Emmanuelle Charpentier. The case was sent back to the Patent Office’s Patent Trial and Appeal Board for reconsideration after the court found fault with a previous patent tribunal’s
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Identification of non-canonical peptides with moPepGen Nat. Biotechnol. (IF 33.1) Pub Date : 2025-06-16 Chenghao Zhu, Lydia Y. Liu, Annie Ha, Takafumi N. Yamaguchi, Helen Zhu, Rupert Hugh-White, Julie Livingstone, Yash Patel, Thomas Kislinger, Paul C. Boutros
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Limitations of cell embedding metrics assessed using drifting islands Nat. Biotechnol. (IF 33.1) Pub Date : 2025-06-11 Hanchen Wang, Jure Leskovec, Aviv Regev
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Go fund a brain gain Nat. Biotechnol. (IF 33.1) Pub Date : 2025-06-10
The gutting of US research funding represents a once-in-a-generation opportunity for Europe to boost world-class research deprioritized by the Trump administration.
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Individualized mRNA cancer vaccines make strides Nat. Biotechnol. (IF 33.1) Pub Date : 2025-06-10
The first cancer vaccines matched to a person’s unique tumor neoantigens are forging ahead, with expectations running high as the field awaits results from the first pivotal trial.
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Delivering base editors to the liver and lungs in alpha-1 antitrypsin deficiency Nat. Biotechnol. (IF 33.1) Pub Date : 2025-06-09
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Base editors model mitochondrial disease Nat. Biotechnol. (IF 33.1) Pub Date : 2025-06-03 Patrick Buchholz, Jens Boch
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Resurrecting a miniature Cas9 ancestor for genome and epigenome editing Nat. Biotechnol. (IF 33.1) Pub Date : 2025-06-03 Gabriel L. Butterfield, Charles A. Gersbach
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Powering new therapeutics with precision mitochondrial editing Nat. Biotechnol. (IF 33.1) Pub Date : 2025-06-03
More precise base editors make mitochondrial DNA editing efficient enough to model disease and correct pathogenic mutations in rodents, but they are slow to move into clinical trials.
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A mitochondrial disease model is generated and corrected using engineered base editors in rat zygotes Nat. Biotechnol. (IF 33.1) Pub Date : 2025-06-03 Liang Chen, Changming Luan, Mengjia Hong, Meng Yuan, Hao Huang, Debo Gao, Xinyuan Guo, Zhengxin Chen, Yongmei Li, Lei Yang, Zongyi Yi, Wensheng Wei, Mingyao Liu, Liangcai Gao, Honghui Han, Dali Li
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Efficient mitochondrial A-to-G base editors for the generation of mitochondrial disease models Nat. Biotechnol. (IF 33.1) Pub Date : 2025-06-03 Liang Chen, Mengjia Hong, Changming Luan, Meng Yuan, Yiming Wang, Xinyuan Guo, Yue Fang, Hao Huang, Xiaohua Dong, Hongyi Gao, Dan Zhang, Xi Chen, Dihao Meng, Molin Huang, Zongyi Yi, Mingyao Liu, Wensheng Wei, Liangcai Gao, Gaojie Song, Xiaoming Zhou, Dali Li
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Improving gene isoform quantification with miniQuant Nat. Biotechnol. (IF 33.1) Pub Date : 2025-06-03 Haoran Li, Dingjie Wang, Qi Gao, Puwen Tan, Yunhao Wang, Xiaoyu Cai, Aifu Li, Yue Zhao, Andrew L. Thurman, Seyed Amir Malekpour, Ying Zhang, Roberta Sala, Andrea Cipriano, Chia-Lin Wei, Vittorio Sebastiano, Chi Song, Nancy R. Zhang, Kin Fai Au
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Merck’s anti-RSV antibody expands protection for infants Nat. Biotechnol. (IF 33.1) Pub Date : 2025-06-02
Merck’s new antibody clesrovimab and other long-lasting shots promise to both expand and simplify care of newborns across the world to combat respiratory syncytial virus.
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Dual SORT LNPs for multi-organ base editing Nat. Biotechnol. (IF 33.1) Pub Date : 2025-06-02 Minjeong Kim, Eunice S. Song, Joseph C. Chen, Sumanta Chatterjee, Yehui Sun, Sang M. Lee, Shiying Wu, Priyanka Patel, Zeru Tian, Ariel Kantor, Brandon A. Wustman, David J. Lockhart, Daniel J. Siegwart
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Anatomy of the 23andMe fall and implications for consumer genomics Nat. Biotechnol. (IF 33.1) Pub Date : 2025-05-29 Yaniv Erlich, Dina Zielinski
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Self-supervised learning from small-molecule mass spectrometry data Nat. Biotechnol. (IF 33.1) Pub Date : 2025-05-23 Wout Bittremieux, William Stafford Noble
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Self-supervised learning of molecular representations from millions of tandem mass spectra using DreaMS Nat. Biotechnol. (IF 33.1) Pub Date : 2025-05-23 Roman Bushuiev, Anton Bushuiev, Raman Samusevich, Corinna Brungs, Josef Sivic, Tomáš Pluskal
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Deep-learning-based single-domain and multidomain protein structure prediction with D-I-TASSER Nat. Biotechnol. (IF 33.1) Pub Date : 2025-05-23 Wei Zheng, Qiqige Wuyun, Yang Li, Quancheng Liu, Xiaogen Zhou, Chunxiang Peng, Yiheng Zhu, Lydia Freddolino, Yang Zhang
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Beyond cell atlases: spatial biology reveals mechanisms behind disease Nat. Biotechnol. (IF 33.1) Pub Date : 2025-05-21
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A multi-kingdom genetic barcoding system for precise clone isolation Nat. Biotechnol. (IF 33.1) Pub Date : 2025-05-21 Soh Ishiguro, Kana Ishida, Rina C. Sakata, Minori Ichiraku, Ren Takimoto, Rina Yogo, Yusuke Kijima, Hideto Mori, Mamoru Tanaka, Samuel King, Shoko Tarumoto, Taro Tsujimura, Omar Bashth, Nanami Masuyama, Arman Adel, Hiromi Toyoshima, Motoaki Seki, Ju Hee Oh, Anne-Sophie Archambault, Keiji Nishida, Akihiko Kondo, Satoru Kuhara, Hiroyuki Aburatani, Ramon I. Klein Geltink, Takuya Yamamoto, Nika Shakiba
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Retargeted retrotransposons insert multi-kilobase cargo at new sites Nat. Biotechnol. (IF 33.1) Pub Date : 2025-05-16 Iris Marchal
Site-specific retroelements, such as R2 retrotransposons, have potential as programmable genome-editing systems, but so far have only been used for targeted insertion at genomic safe-harbor loci. In a paper now published in Nature, Fell et al. profile the evolution of site-specific retrotransposon families to gain insight into target site preferences, which they then used to engineer reprogramming
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A gut-derived peptide protects citrus trees from Huanglongbing Nat. Biotechnol. (IF 33.1) Pub Date : 2025-05-16 Iris Marchal
Huanglongbing is a devastating bacterial disease of citrus trees with no known cure. An emerging strategy to provide resistance to plant pathogens is disrupting genes that increase disease susceptibility. A paper in Science by Zhao et al. uses this approach in citrus trees, and identifies a regulatory circuit that can be modulated to alleviate Huanglongbing disease symptoms. Huanglongbing can infect
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Author Correction: Efficient C-to-T base editing in plants using a fusion of nCas9 and human APOBEC3A Nat. Biotechnol. (IF 33.1) Pub Date : 2025-05-16 Yuan Zong, Qianna Song, Chao Li, Shuai Jin, Dingbo Zhang, Yanpeng Wang, Jin-Long Qiu, Caixia Gao
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Bioprinting Nat. Biotechnol. (IF 33.1) Pub Date : 2025-05-16
Recent patents relating to systems, methods and compositions for bioprinting.
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Reprogramming endogenous regulatory DNA to fine-tune gene expression Nat. Biotechnol. (IF 33.1) Pub Date : 2025-05-16 Iris Marchal
Regulatory DNA sequences orchestrate cell-type-specific gene expression by facilitating transcription factor binding, yet their precise effects and reprogrammability remain challenging to delineate. Now, in Cell, Martyn et al. develop a method called variant effects from flow-sorting experiments with CRISPR targeting screens (Variant-EFFECTS), which measures the quantitative effects of changes to regulatory
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Fruit waste for catwalk fashion Nat. Biotechnol. (IF 33.1) Pub Date : 2025-05-16
Polybion creates this next-generation material by feeding a mango fruit waste slurry to Acetobacter bacteria genetically modified to speed up their metabolism. The bacteria feed on the sugar and turn it into cellulose to form a gel-like mat on the surface of the fermentation tank. Bacteria employ this strategy to survive in harsh environments. “It’s a shelter they create [against] the radiation of
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People Nat. Biotechnol. (IF 33.1) Pub Date : 2025-05-16
Recent moves of note in and around the biotech and pharma industries.
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Engineering non-viral protein nanoparticles to deliver nucleic acids and proteins to cells Nat. Biotechnol. (IF 33.1) Pub Date : 2025-05-16
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The Biotech Explorers Pathway equips students for STEM futures Nat. Biotechnol. (IF 33.1) Pub Date : 2025-05-16 Anne E. Robinson, Barrie Cascella, Marta M. Wegorzewska, Daniel A. Berkovich, Joseph M. Jez
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3D bioprinting innovation and the patentability hurdle Nat. Biotechnol. (IF 33.1) Pub Date : 2025-05-16 Pratap Devarapalli, Dianne Nicol, Jane Nielsen
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Biopharma dives into tumor-seeking radioactive drugs Nat. Biotechnol. (IF 33.1) Pub Date : 2025-05-16
Big pharma and investors are piling into the precision radiation space as the next generation of increasingly potent targeted α-particle therapies promises to destroy cancerous cells with minimum damage to healthy tissues.
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Consternation follows Marks’ FDA departure Nat. Biotechnol. (IF 33.1) Pub Date : 2025-05-16
In late March, the US Food and Drug Administration’s (FDA) director of the Center for Biologics Evaluation and Research, Peter Marks, resigned under pressure from Health and Human Services Secretary Robert F. Kennedy. In his resignation letter Marks said he had been asked to hand in data on measles vaccine-related deaths and brain swelling that do not exist.
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Brazil’s low-cost CAR-Ts take on Global South Nat. Biotechnol. (IF 33.1) Pub Date : 2025-05-16
Brazil is the first country in Latin America to produce its own cut-price chimeric antigen receptor (CAR)-T cell therapies. Now, Caring Cross, a US-based non-profit focused on making advanced therapies affordable, plans to expands Brazil’s model to Turkey and the Middle East.
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Biotech news from around the world Nat. Biotechnol. (IF 33.1) Pub Date : 2025-05-16
As part of its Dare2eraD TB initiative to combat the challenge of drug-resistant tuberculosis, Indian researchers sequence the genomes of 10,000 Mycobacterium tuberculosis isolates. Sequencing will aid in personalizing antibiotic prescription, allowing faster, more effective treatment. India has set the goal of eliminating TB by 2025, five years ahead of the World Health Organization’s global target
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FDA pushes to replace animal testing Nat. Biotechnol. (IF 33.1) Pub Date : 2025-05-16
The US Food and Drug Administration plans to introduce computational modeling and other innovative methods to replace animal testing in preclinical drug safety studies, according to a roadmap released in April. By encouraging drug sponsors to embrace organ-on-a chip, in silico modeling, organoid and other in vitro assays, the FDA aims to reduce animal testing to the extent that it becomes “the exception
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Self-assembling protein nanoparticles for cytosolic delivery of nucleic acids and proteins Nat. Biotechnol. (IF 33.1) Pub Date : 2025-05-15 Feyisayo Eweje, Vanessa Ibrahim, Aram Shajii, Michelle L. Walsh, Kiran Ahmad, Assma Alrefai, Dominie Miyasato, Jessie R. Davis, Hyunok Ham, Kaicheng Li, Michael Roehrl, Carolyn A. Haller, David R. Liu, Jiaxuan Chen, Elliot L. Chaikof
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Proteoform profiling of endogenous single cells from rat hippocampus at scale Nat. Biotechnol. (IF 33.1) Pub Date : 2025-05-15 Pei Su, Michael A. R. Hollas, Indira Pla, Stanislav Rubakhin, Fatma Ayaloglu Butun, Joseph B. Greer, Bryan P. Early, Ryan T. Fellers, Michael A. Caldwell, Jonathan V. Sweedler, Jared O. Kafader, Neil L. Kelleher
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Targeting a cell surface RNA-binding protein driving acute myeloid leukemia Nat. Biotechnol. (IF 33.1) Pub Date : 2025-05-12
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Author Correction: Droplet Hi-C enables scalable, single-cell profiling of chromatin architecture in heterogeneous tissues Nat. Biotechnol. (IF 33.1) Pub Date : 2025-05-12 Lei Chang, Yang Xie, Brett Taylor, Zhaoning Wang, Jiachen Sun, Ethan J. Armand, Shreya Mishra, Jie Xu, Melodi Tastemel, Audrey Lie, Zane A. Gibbs, Hannah S. Indralingam, Tuyet M. Tan, Rafael Bejar, Clark C. Chen, Frank B. Furnari, Ming Hu, Bing Ren
Correction to: Nature Biotechnology https://doi.org/10.1038/s41587-024-02447-1, published online 18 October 2024.
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Evolution-guided protein design of IscB for persistent epigenome editing in vivo Nat. Biotechnol. (IF 33.1) Pub Date : 2025-05-07 Soumya Kannan, Han Altae-Tran, Shiyou Zhu, Peiyu Xu, Daniel Strebinger, Rachel Oshiro, Guilhem Faure, Lukas Moeller, Julie Pham, Kepler S. Mears, Heyuan M. Ni, Rhiannon K. Macrae, Feng Zhang
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The TransEuro open-label trial of human fetal ventral mesencephalic transplantation in patients with moderate Parkinson’s disease Nat. Biotechnol. (IF 33.1) Pub Date : 2025-05-02 Roger A. Barker, Nicholas P. Lao-Kaim, Natalie Valle Guzman, Dilan Athauda, Hjalmar Bjartmarz, Anders Björklund, Alistair Church, Emma Cutting, Danielle Daft, Viswas Dayal, Stephen Dunnett, Amy Evans, Shane Grealish, Naomi Hannaway, Xiaoling He, Sam Hewitt, Zinovia Kefalopoulou, Philipp Mahlknecht, Antonio Martín-Bastida, Krista Farrell, Sarah Moore, Harry Bulstrode, Tagore Nakornchai, Jenny Nelander-Wahlestedt
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A tissue-specific atlas of protein–protein associations enables prioritization of candidate disease genes Nat. Biotechnol. (IF 33.1) Pub Date : 2025-05-02 Diederik S. Laman Trip, Marc van Oostrum, Danish Memon, Fabian Frommelt, Delora Baptista, Kalpana Panneerselvam, Glyn Bradley, Luana Licata, Henning Hermjakob, Sandra Orchard, Gosia Trynka, Ellen M. McDonagh, Andrea Fossati, Ruedi Aebersold, Matthias Gstaiger, Bernd Wollscheid, Pedro Beltrao
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Environmental monitoring from the air with hyperspectral reporters Nat. Biotechnol. (IF 33.1) Pub Date : 2025-04-29 Maxwell Z. Wilson
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Application of a sunlight-switched sugar signal increases wheat yield in the field Nat. Biotechnol. (IF 33.1) Pub Date : 2025-04-29
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Membrane-permeable trehalose 6-phosphate precursor spray increases wheat yields in field trials Nat. Biotechnol. (IF 33.1) Pub Date : 2025-04-29 Cara A. Griffiths, Xiaochao Xue, Javier A. Miret, Fernando Salvagiotti, Liana G. Acevedo-Siaca, Jacinta Gimeno, Matthew P. Reynolds, Kirsty L. Hassall, Kirstie Halsey, Swati Puranik, Maria Oszvald, Smita Kurup, Benjamin G. Davis, Matthew J. Paul
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Enabling next-generation anaerobic cultivation through biotechnology to advance functional microbiome research Nat. Biotechnol. (IF 33.1) Pub Date : 2025-04-29 Thomas Clavel, Franziska Faber, Mathieu Groussin, Dirk Haller, Jörg Overmann, Charlie Pauvert, Mathilde Poyet, Joel Selkrig, Bärbel Stecher, Athanasios Typas, Maria J. G. T. Vehreschild, Alexander J. Westermann, David Wylensek, Lisa Maier
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A call for built-in biosecurity safeguards for generative AI tools Nat. Biotechnol. (IF 33.1) Pub Date : 2025-04-28 Mengdi Wang, Zaixi Zhang, Amrit Singh Bedi, Alvaro Velasquez, Stephanie Guerra, Sheng Lin-Gibson, Le Cong, Yuanhao Qu, Souradip Chakraborty, Megan Blewett, Jian Ma, Eric Xing, George Church
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Chemigenetic kinase biosensors illuminate cell signaling networks Nat. Biotechnol. (IF 33.1) Pub Date : 2025-04-28 Katarina Nemec, Vikas D. Trivedi, M. Madan Babu