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Structure-based evolutionary relationship between IscB and Cas9 Cell Res. (IF 46.297) Pub Date : 2022-08-05 Ning Jia, Dinshaw J. Patel
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Sustaining plant immunity in rising temperature Cell Res. (IF 46.297) Pub Date : 2022-08-05 Jian Hua, Xinnian Dong
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R-2-HG assists IDH1-mutant solid tumors by promoting angiogenesis Cell Res. (IF 46.297) Pub Date : 2022-08-05 Nuray Bögürcü-Seidel, Gabriele Bergers
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Inducing Z-DNA overcomes immune checkpoint blockade resistance Cell Res. (IF 46.297) Pub Date : 2022-08-01 Huipeng Jiao, Manolis Pasparakis
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Omicron-specific mRNA vaccine elicits potent immune responses in mice, hamsters, and nonhuman primates Cell Res. (IF 46.297) Pub Date : 2022-08-01 Yi Wu, Yanqiong Shen, Namei Wu, Xinghai Zhang, Shaohong Chen, Chang Yang, Junhui Zhou, Yan Wu, Da Chen, Li Wang, Chao Wang, Huajun Zhang, Ninuo Xia, Sandra Chiu, Yucai Wang
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Run! White blood cells cued by a motor brain under stress. Cell Res. (IF 46.297) Pub Date : 2022-08-01 Hai Qi,Bo Liu
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Hetero-bivalent nanobodies provide broad-spectrum protection against SARS-CoV-2 variants of concern including Omicron Cell Res. (IF 46.297) Pub Date : 2022-07-29 Huan Ma, Xinghai Zhang, Peiyi Zheng, Peter H. Dube, Weihong Zeng, Shaohong Chen, Qingyu Cheng, Yunru Yang, Yan Wu, Junhui Zhou, Xiaowen Hu, Yan Xiang, Huajun Zhang, Sandra Chiu, Tengchuan Jin
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AHI1: linking depression and impaired antiviral immune response Cell Res. (IF 46.297) Pub Date : 2022-07-20 Weili Yang, Shihua Li, Xiao-Jiang Li
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Profiling spatial gene activity in marmoset embryos. Cell Res. (IF 46.297) Pub Date : 2022-07-20 Guangdun Peng,Patrick P L Tam
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Efficient replication of human nuclear DNA. Cell Res. (IF 46.297) Pub Date : 2022-07-20 Thomas A Kunkel
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Arc weakens synapses by dispersing AMPA receptors from postsynaptic density via modulating PSD phase separation Cell Res. (IF 46.297) Pub Date : 2022-07-18 Xudong Chen, Bowen Jia, Yoichi Araki, Bian Liu, Fei Ye, Richard Huganir, Mingjie Zhang
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Human adult hippocampal neurogenesis is back, again? Cell Res. (IF 46.297) Pub Date : 2022-07-18 Hai-Kun Liu
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Glutamate drives ‘local Ca2+ release’ in cardiac pacemaker cells Cell Res. (IF 46.297) Pub Date : 2022-07-15 Duanyang Xie, Ke Xiong, Xuling Su, Guanghua Wang, Qicheng Zou, Luxin Wang, Caihong Zhang, Yuting Cao, Beihua Shao, Yixin Zhang, Peidong Zhang, Dandan Liang, Yi Liu, Yi-Han Chen
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Shaping the sinuses: a novel Krt14+Ctsk+ cell lineage driving regenerative bone formation Cell Res. (IF 46.297) Pub Date : 2022-07-14 Seoyeon Bok, Matthew B. Greenblatt
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A novel lineage of osteoprogenitor cells with dual epithelial and mesenchymal properties govern maxillofacial bone homeostasis and regeneration after MSFL Cell Res. (IF 46.297) Pub Date : 2022-07-12 Yuteng Weng, Haicheng Wang, Di Wu, Shuyu Xu, Xiaofan Chen, Jie Huang, Yanhuizhi Feng, Lin Li, Zuolin Wang
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A super pan-genomic landscape of rice Cell Res. (IF 46.297) Pub Date : 2022-07-12 Lianguang Shang, Xiaoxia Li, Huiying He, Qiaoling Yuan, Yanni Song, Zhaoran Wei, Hai Lin, Min Hu, Fengli Zhao, Chao Zhang, Yuhua Li, Hongsheng Gao, Tianyi Wang, Xiangpei Liu, Hong Zhang, Ya Zhang, Shuaimin Cao, Xiaoman Yu, Bintao Zhang, Yong Zhang, Yiqing Tan, Mao Qin, Cheng Ai, Yingxue Yang, Bin Zhang, Zhiqiang Hu, Hongru Wang, Yang Lv, Yuexing Wang, Jie Ma, Quan Wang, Hongwei Lu, Zhe Wu, Shanlin
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Promoting T and NK cell attack: preserving tumor MICA/B by vaccines Cell Res. (IF 46.297) Pub Date : 2022-07-12 Frank Cichocki, Jeffrey S. Miller
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Depression compromises antiviral innate immunity via the AVP-AHI1-Tyk2 axis Cell Res. (IF 46.297) Pub Date : 2022-07-12 Hong-Guang Zhang, Bin Wang, Yong Yang, Xuan Liu, Junjie Wang, Ning Xin, Shifeng Li, Ying Miao, Qiuyu Wu, Tingting Guo, Yukang Yuan, Yibo Zuo, Xiangjie Chen, Tengfei Ren, Chunsheng Dong, Jun Wang, Hang Ruan, Miao Sun, Xingshun Xu, Hui Zheng
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Treatment for giant congenital nevi moves a step closer Cell Res. (IF 46.297) Pub Date : 2022-07-07 Joanna Pozniak, Jean-Christophe Marine
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Towards capturing of totipotency Cell Res. (IF 46.297) Pub Date : 2022-07-05 Cuiqing Zhong, Ronghui Li, Juan Carlos Izpisua Belmonte
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GLP-1 appetite control via intestinofugal neurons. Cell Res. (IF 46.297) Pub Date : 2022-08-01 Nick J Spencer,Tim J Hibberd
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A BAF-fling connection to RIPK1 Cell Res. (IF 46.297) Pub Date : 2022-07-04 Jessica M. Gullett, Thirumala-Devi Kanneganti
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A broadly neutralizing antibody against SARS-CoV-2 Omicron variant infection exhibiting a novel trimer dimer conformation in spike protein binding Cell Res. (IF 46.297) Pub Date : 2022-06-29 Yingdan Wang, Wuqiang Zhan, Jiangyan Liu, Yanqun Wang, Xiang Zhang, Meng Zhang, Lin Han, Yunping Ma, Lu Lu, Yumei Wen, Zhenguo Chen, Jincun Zhao, Fan Wu, Lei Sun, Jinghe Huang
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CTCF organizes inter-A compartment interactions through RYBP-dependent phase separation Cell Res. (IF 46.297) Pub Date : 2022-06-29 Chao Wei, Lumeng Jia, Xiaona Huang, Jin Tan, Mulan Wang, Jing Niu, Yingping Hou, Jun Sun, Pengguihang Zeng, Jia Wang, Li Qing, Lin Ma, Xinyi Liu, Xiuxiao Tang, Fenjie Li, Shaoshuai Jiang, Jingxin Liu, Tingting Li, Lili Fan, Yujie Sun, Juntao Gao, Cheng Li, Junjun Ding
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Transcriptome dynamics of hippocampal neurogenesis in macaques across the lifespan and aged humans Cell Res. (IF 46.297) Pub Date : 2022-06-24 Wei Wang, Mengdi Wang, Meng Yang, Bo Zeng, Wenying Qiu, Qiang Ma, Xiaoxi Jing, Qianqian Zhang, Bosong Wang, Chonghai Yin, Jiyao Zhang, Yuxin Ge, Yufeng Lu, Weizhi Ji, Qian Wu, Chao Ma, Xiaoqun Wang
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A SNIPpet of safety: a Goldilocks approach in CAR-T therapy Cell Res. (IF 46.297) Pub Date : 2022-06-23 Mehdi Benzaoui, Naomi Taylor, Nirali N. Shah
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Structural insights into ligand recognition and selectivity of somatostatin receptors Cell Res. (IF 46.297) Pub Date : 2022-06-23 Wenli Zhao, Shuo Han, Na Qiu, Wenbo Feng, Mengjie Lu, Wenru Zhang, Mu Wang, Qingtong Zhou, Shutian Chen, Wei Xu, Juan Du, Xiaojing Chu, Cuiying Yi, Antao Dai, Liaoyuan Hu, Michelle Y. Shen, Yaping Sun, Qing Zhang, Yingli Ma, Wenge Zhong, Dehua Yang, Ming-Wei Wang, Beili Wu, Qiang Zhao
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Basophils orchestrate kidney fibrosis Cell Res. (IF 46.297) Pub Date : 2022-06-20 Camille Chauvin, Jagadeesh Bayry
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Structure of human NTCP reveals the basis of recognition and sodium-driven transport of bile salts into the liver Cell Res. (IF 46.297) Pub Date : 2022-06-20 Hongtao Liu, Rossitza N. Irobalieva, Rose Bang-Sørensen, Kamil Nosol, Somnath Mukherjee, Parth Agrawal, Bruno Stieger, Anthony A. Kossiakoff, Kaspar P. Locher
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Selection and structural bases of potent broadly neutralizing antibodies from 3-dose vaccinees that are highly effective against diverse SARS-CoV-2 variants, including Omicron sublineages. Cell Res. (IF 46.297) Pub Date : 2022-06-07 Lei Wang,Wangjun Fu,Linlin Bao,Zijing Jia,Yuxia Zhang,Yunjiao Zhou,Wei Wu,Jianbo Wu,Qianqian Zhang,Yidan Gao,Kang Wang,Qiao Wang,Chuan Qin,Xiangxi Wang
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Disease profile and plasma neutralizing activity of post-vaccination Omicron BA.1 infection in Tianjin, China: a retrospective study. Cell Res. (IF 46.297) Pub Date : 2022-06-07 Hong Zheng,Yunlong Cao,Xiaosu Chen,Fengmei Wang,Ye Hu,Weiliang Song,Yangyang Chai,Qingqing Gu,Yansong Shi,Yingmei Feng,Shuxun Liu,Yan Xie,Xiaoliang Sunney Xie,Wentao Jiang,Zhongyang Shen
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Phase separation of Ddx3xb helicase regulates maternal-to-zygotic transition in zebrafish Cell Res. (IF 46.297) Pub Date : 2022-06-03 Boyang Shi, Jian Heng, Jia-Yi Zhou, Ying Yang, Wan-Ying Zhang, Magdalena J. Koziol, Yong-Liang Zhao, Pilong Li, Feng Liu, Yun-Gui Yang
Vertebrate embryogenesis involves a conserved and fundamental process, called the maternal-to-zygotic transition (MZT), which marks the switch from a maternal factors-dominated state to a zygotic factors-driven state. Yet the precise mechanism underlying MZT remains largely unknown. Here we report that the RNA helicase Ddx3xb in zebrafish undergoes liquid–liquid phase separation (LLPS) via its N-terminal
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Nuclear RIPK1 promotes chromatin remodeling to mediate inflammatory response Cell Res. (IF 46.297) Pub Date : 2022-06-03 Wanjin Li, Bing Shan, Chengyu Zou, Huibing Wang, Meng-Meng Zhang, Hong Zhu, Masanori Gomi Naito, Daichao Xu, Vica Jean Manuel, Lauren Mifflin, Zhaodong Hou, John Ravits, Junying Yuan
RIPK1 is a master regulator of multiple cell death pathways, including apoptosis and necroptosis, and inflammation. Importantly, activation of RIPK1 has also been shown to promote the transcriptional induction of proinflammatory cytokines in cells undergoing necroptosis, in animal models of amyotrophic lateral sclerosis (ALS) and Alzheimer’s disease (AD), and in human ALS and AD. Rare human genetic
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Structural and biochemical mechanism for increased infectivity and immune evasion of Omicron BA.2 variant compared to BA.1 and their possible mouse origins Cell Res. (IF 46.297) Pub Date : 2022-05-31 Youwei Xu, Canrong Wu, Xiaodan Cao, Chunyin Gu, Heng Liu, Mengting Jiang, Xiaoxi Wang, Qingning Yuan, Kai Wu, Jia Liu, Deyi Wang, Xianqing He, Xueping Wang, Su-Jun Deng, H. Eric Xu, Wanchao Yin
The Omicron BA.2 variant has become a dominant infective strain worldwide. Receptor binding studies show that the Omicron BA.2 spike trimer exhibits 11-fold and 2-fold higher potency in binding to human ACE2 than the spike trimer from the wildtype (WT) and Omicron BA.1 strains. The structure of the BA.2 spike trimer complexed with human ACE2 reveals that all three receptor-binding domains (RBDs) in
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Up or down: where comes Omicron? Cell Res. (IF 46.297) Pub Date : 2022-07-01 Zezhong Liu,Lu Lu,Shibo Jiang
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Maternally loaded RNAs: no time to die. Cell Res. (IF 46.297) Pub Date : 2022-08-01 Martino Ugolini,Nadine L Vastenhouw
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Cytoskeleton grows p62 condensates for autophagy. Cell Res. (IF 46.297) Pub Date : 2022-07-01 Nobuo N Noda
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Structures of the endogenous peptide- and selective non-peptide agonist-bound SSTR2 signaling complexes. Cell Res. (IF 46.297) Pub Date : 2022-05-16 Li-Nan Chen,Wei-Wei Wang,Ying-Jun Dong,Dan-Dan Shen,Jia Guo,Xuefei Yu,Jiao Qin,Su-Yu Ji,Huibing Zhang,Qingya Shen,Qiaojun He,Bo Yang,Yan Zhang,Qinglin Li,Chunyou Mao
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Derivation of totipotent-like stem cells with blastocyst-like structure forming potential Cell Res. (IF 46.297) Pub Date : 2022-05-04 Yaxing Xu, Jingru Zhao, Yixuan Ren, Xuyang Wang, Yulin Lyu, Bingqing Xie, Yiming Sun, Xiandun Yuan, Haiyin Liu, Weifeng Yang, Yenan Fu, Yu Yu, Yinan Liu, Rong Mu, Cheng Li, Jun Xu, Hongkui Deng
It is challenging to derive totipotent stem cells in vitro that functionally and molecularly resemble cells from totipotent embryos. Here, we report that a chemical cocktail enables the derivation of totipotent-like stem cells, designated as totipotent potential stem (TPS) cells, from 2-cell mouse embryos and extended pluripotent stem cells, and that these TPS cells can be stably maintained long term
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Retractosomes: small extracellular vesicles generated from broken-off retraction fibers. Cell Res. (IF 46.297) Pub Date : 2022-05-04 Yizheng Wang,Shuaixin Gao,Yuheng Liu,Dongju Wang,Boqi Liu,Dong Jiang,Catherine C L Wong,Yang Chen,Li Yu
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Myosin 1D and the branched actin network control the condensation of p62 bodies Cell Res. (IF 46.297) Pub Date : 2022-04-27 Xuezhao Feng, Wanqing Du, Mingrui Ding, Wenkang Zhao, Xirenayi Xirefu, Meisheng Ma, Yuhui Zhuang, Xiaoyu Fu, Jiangfeng Shen, Jinpei Zhang, Xiuying Lei, Daxiao Sun, Qing Xi, Yiliyasi Aisa, Qian Chen, Ying Li, Wenjuan Wang, Shanjin Huang, Li Yu, Pilong Li, Na Mi
Biomolecular condensation driven by liquid–liquid phase separation (LLPS) is key to assembly of membraneless organelles in numerous crucial pathways. It is largely unknown how cellular structures or components spatiotemporally regulate LLPS and condensate formation. Here we reveal that cytoskeletal dynamics can control the condensation of p62 bodies comprising the autophagic adaptor p62/SQSTM1 and
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Generic amyloid fibrillation of TMEM106B in patient with Parkinson's disease dementia and normal elders. Cell Res. (IF 46.297) Pub Date : 2022-04-27 Yun Fan,Qinyue Zhao,Wencheng Xia,Youqi Tao,Wenbo Yu,Mingjia Chen,Yiqi Liu,Jue Zhao,Yan Shen,Yunpeng Sun,Chenfang Si,Shenqing Zhang,Yaoyang Zhang,Wensheng Li,Cong Liu,Jian Wang,Dan Li
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Structural basis for pore blockade of human voltage-gated calcium channel Cav1.3 by motion sickness drug cinnarizine. Cell Res. (IF 46.297) Pub Date : 2022-04-27 Xia Yao,Shuai Gao,Nieng Yan
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SLC1A1-mediated cellular and mitochondrial influx of R-2-hydroxyglutarate in vascular endothelial cells promotes tumor angiogenesis in IDH1-mutant solid tumors Cell Res. (IF 46.297) Pub Date : 2022-04-22 Xiaomin Wang, Ziqi Chen, Jun Xu, Shuai Tang, Nan An, Lei Jiang, Yixiang Zhang, Shaoying Zhang, Qingli Zhang, Yanyan Shen, Shijie Chen, Xiaojing Lan, Ting Wang, Linhui Zhai, Siyuwei Cao, Siqi Guo, Yingluo Liu, Aiwei Bi, Yuehong Chen, Xiameng Gai, Yichen Duan, Ying Zheng, Yixian Fu, Yize Li, Liang Yuan, Linjiang Tong, Kun Mo, Mingcheng Wang, Shu-Hai Lin, Minjia Tan, Cheng Luo, Yi Chen, Jia Liu, Qiansen
Mutant isocitrate dehydrogenase 1 (mIDH1) drives tumorigenesis via producing oncometabolite R-2-hydroxyglutarate (R-2-HG) across various tumor types. However, mIDH1 inhibitors appear only effective in hematological tumors. The therapeutic benefit in solid tumors remains elusive, likely due to the complex tumor microenvironment. In this study, we discover that R-2-HG produced by IDH1-mutant tumor cells
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Discovery of small-molecule activators of nicotinamide phosphoribosyltransferase (NAMPT) and their preclinical neuroprotective activity Cell Res. (IF 46.297) Pub Date : 2022-04-22 Hong Yao, Minghui Liu, Leibo Wang, Yumeng Zu, Chou Wu, Chenyu Li, Ruoxi Zhang, Haigen Lu, Feifei Li, Shuang Xi, Shuangquan Chen, Xuanyu Gu, Tianya Liu, Jie Cai, Shirong Wang, Maojun Yang, Guo-Gang Xing, Wei Xiong, Lan Hua, Yefeng Tang, Gelin Wang
The decline of nicotinamide adenine dinucleotide (NAD) occurs in a variety of human pathologies including neurodegeneration. NAD-boosting agents can provide neuroprotective benefits. Here, we report the discovery and development of a class of potent activators (NATs) of nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme in the NAD salvage pathway. We obtained the crystal structure
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Krebs and an alternative TCA cycle! Cell Res. (IF 46.297) Pub Date : 2022-06-01 Mary T Doan,Michael A Teitell
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Dynamic nucleosome organization after fertilization reveals regulatory factors for mouse zygotic genome activation Cell Res. (IF 46.297) Pub Date : 2022-04-15 Chenfei Wang, Chuan Chen, Xiaoyu Liu, Chong Li, Qiu Wu, Xiaolan Chen, Lingyue Yang, Xiaochen Kou, Yanhong Zhao, Hong Wang, Yawei Gao, Yong Zhang, Shaorong Gao
Chromatin remodeling is essential for epigenome reprogramming after fertilization. However, the underlying mechanisms of chromatin remodeling remain to be explored. Here, we investigated the dynamic changes in nucleosome occupancy and positioning in pronucleus-stage zygotes using ultra low-input MNase-seq. We observed distinct features of inheritance and reconstruction of nucleosome positioning in
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piRNA 3' uridylation facilitates the assembly of MIWI/piRNA complex for efficient target regulation in mouse male germ cells. Cell Res. (IF 46.297) Pub Date : 2022-04-15 Mao-Zhou Zhao,Di-Hang Lin,Heng Zuo,Huan Wei,Xin Wang,Lan-Tao Gou,Mo-Fang Liu
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PEN2: Metformin's new partner at lysosome. Cell Res. (IF 46.297) Pub Date : 2022-06-01 Kei Sakamoto,Niels Jessen
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Nuclear tetraspanin 8 promotes breast cancer progression. Cell Res. (IF 46.297) Pub Date : 2022-06-01 Kadellyn Sandoval,William A Weiss
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Structural insights into the SARS-CoV-2 Omicron RBD-ACE2 interaction. Cell Res. (IF 46.297) Pub Date : 2022-04-13 Jun Lan,Xinheng He,Yifei Ren,Ziyi Wang,Huan Zhou,Shilong Fan,Chenyou Zhu,Dongsheng Liu,Bin Shao,Tie-Yan Liu,Qisheng Wang,Linqi Zhang,Jiwan Ge,Tong Wang,Xinquan Wang
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Enhanced trimeric ACE2 exhibits potent prophylactic and therapeutic efficacy against the SARS-CoV-2 Delta and Omicron variants in vivo. Cell Res. (IF 46.297) Pub Date : 2022-04-13 Mengjiao Li,Zi-Wei Ye,Kaiming Tang,Liang Guo,Wenwen Bi,Yuyuan Zhang,Yan-Dong Tang,Guoguang Rong,Mohamad Sawan,Xin Yin,Ren Sun,Shuofeng Yuan,Bobo Dang
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A gut feeling: diet-sensing mesenchymal cells regulate intestinal stem cell function. Cell Res. (IF 46.297) Pub Date : 2022-04-06 Julia Messina-Pacheco,Alex Gregorieff
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Gut microbiota drives macrophage-dependent self-renewal of intestinal stem cells via niche enteric serotonergic neurons Cell Res. (IF 46.297) Pub Date : 2022-04-04 Pingping Zhu, Tiankun Lu, Jiayi Wu, Dongdong Fan, Benyu Liu, Xiaoxiao Zhu, Hui Guo, Ying Du, Feng Liu, Yong Tian, Zusen Fan
Lgr5+ intestinal stem cells (ISCs) reside within specialized niches at the crypt base and harbor self-renewal and differentiation capacities. ISCs in the crypt base are sustained by their surrounding niche for precise modulation of self-renewal and differentiation. However, how intestinal cells in the crypt niche and microbiota in enteric cavity coordinately regulate ISC stemness remains unclear. Here
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Targeting Hv1 proton channel for pain control. Cell Res. (IF 46.297) Pub Date : 2022-05-01 Kenta Furutani,Ru-Rong Ji
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Author Correction: Receptome profiling identifies KREMEN1 and ASGR1 as alternative functional receptors of SARS-CoV-2 Cell Res. (IF 46.297) Pub Date : 2022-04-01 Yunqing Gu,Jun Cao,Xinyu Zhang,Hai Gao,Yuyan Wang,Jia Wang,Juan He,Xiaoyi Jiang,Jinlan Zhang,Guanghui Shen,Jie Yang,Xichen Zheng,Gaowei Hu,Yuanfei Zhu,Shujuan Du,Yunkai Zhu,Rong Zhang,Jianqing Xu,Fei Lan,Di Qu,Guoliang Xu,Yun Zhao,Dong Gao,Youhua Xie,Min Luo,Zhigang Lu
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Structural insights into ligand binding and activation of the human thyrotropin-releasing hormone receptor. Cell Res. (IF 46.297) Pub Date : 2022-04-01 Youwei Xu,Hongmin Cai,Chongzhao You,Xinheng He,Qingning Yuan,Hualiang Jiang,Xi Cheng,Yi Jiang,H Eric Xu
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Cuproptosis: a copper-triggered modality of mitochondrial cell death. Cell Res. (IF 46.297) Pub Date : 2022-05-01 Daolin Tang,Xin Chen,Guido Kroemer
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Amplifying natural antitumor immunity for personalized immunotherapy. Cell Res. (IF 46.297) Pub Date : 2022-06-01 Laura K Donovan,Michael D Taylor