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Here, we grow Cell Host Microbe (IF 20.6) Pub Date : 2025-06-11 Ella Hinson
Section snippets Main textA microbiologist’s lexicon is filled with words focused on the life cycle of their favorite microorganism, such as growth, replication, and fitness. Researchers log hours at the bench counting PFUs, CFUs, titers, and plotting growth curves and survival. These metrics are key to understanding microbes and how these tiny inhabitants interact with their environments, whether
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Human milk as a microbial pacemaker Cell Host Microbe (IF 20.6) Pub Date : 2025-06-11 Liat Shenhav, Meghan B. Azad, Michael A. Silverman
A Nature Medicine paper by Sawhney et al.1 presents a strain-resolved analysis of the gut microbiome from infancy through eight years of age, identifying weaning as an evolutionary trigger for microbial adaptation. Their findings refine the timeline of microbiome development and highlight human milk as a pacemaker of microbial succession.
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Precision nutrition and the gut microbiome: Harnessing AI to revolutionize cancer prevention and therapy Cell Host Microbe (IF 20.6) Pub Date : 2025-06-11 K. Leigh Greathouse, Ankan Choudhury
The gut microbiome plays a pivotal role in human health, particularly in cancer prevention and treatment. Diet can significantly influence microbiome composition, but individual variability complicates intervention outcomes. We review the microbiome’s influence on cancer development and therapy outcomes and evaluate dietary strategies that modulate microbial composition and metabolites. To address
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The microbiome: An actor or stage for the beneficial action of probiotics, prebiotics, synbiotics, and postbiotics? Cell Host Microbe (IF 20.6) Pub Date : 2025-06-11 Mary Ellen Sanders, Colin Hill
Probiotics, prebiotics, synbiotics, and postbiotics are required, by definition, to confer a health benefit on the host. It is often presumed the host microbiome plays a central role in the mechanism of action of these substances, collectively referred to here as “biotics.” However, the definitions of both probiotics and postbiotics do not include an associated mechanism nor the involvement of the
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Metabolic ecology of microbiomes: Nutrient competition, host benefits, and community engineering Cell Host Microbe (IF 20.6) Pub Date : 2025-06-11 Erik Bakkeren, Vit Piskovsky, Kevin R. Foster
Many plants and animals, including humans, host diverse communities of microbes that provide many benefits. A key challenge in understanding microbiomes is that the species composition often differs among individuals, which can thwart generalization. Here, we argue that the key to identifying general principles for microbiome science lies in microbial metabolism. In the human microbiome and in other
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Origins and functions of microbiome rhythms Cell Host Microbe (IF 20.6) Pub Date : 2025-06-11 Silke Kiessling, Shuaitong Liu, Dirk Haller, Christoph A. Thaiss
Daily oscillations in microbiota composition and function are emerging as an important element in host-microbiota interactions. Here, we summarize features of the microbiota that undergo diurnal rhythms, their development, their impact on the biology of the host, and their relevance to human health and disease. In particular, we focus on the intrinsic and extrinsic factors that regulate microbiota
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Unlocking the power of human milk and infant feeding: Understanding how nutrition and early microbiota interaction shapes health programming Cell Host Microbe (IF 20.6) Pub Date : 2025-06-11 Alexandra Zhernakova, Moran Yassour, Lindsay J. Hall, Maria Carmen Collado
Human milk represents a highly evolved bioactive system that promotes colonization by infant microbial pioneers, supports immune maturation, and fosters infant development. Beyond providing nutrition, human milk contains key bioactive components, such as microbes, metabolites, human milk oligosaccharides, immunoglobulins, lactoferrin, and antimicrobial peptides. These factors influence colonization
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Nutrient acquisition by intracellular parasitic protists Cell Host Microbe (IF 20.6) Pub Date : 2025-06-11 Giel G. van Dooren, Malcolm J. McConville
Parasitic protists belonging to the Apicomplexa and Trypanosomatidae are the cause of important diseases and life-long chronic infections in humans. Several of these parasites replicate within intracellular niches in their mammalian host, including specialized vacuoles, as well as endo-lysosomal compartments or the cytosol of infected cells. These parasites are highly dependent on nutrient salvage
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Microbiome-facilitated plant nutrient acquisition Cell Host Microbe (IF 20.6) Pub Date : 2025-06-11 Brajesh K. Singh, Hang-Wei Hu, Catriona A. Macdonald, Chao Xiong
Plants and microbiomes have co-evolved for millennia. Through this co-evolution, microbiomes have become essential for plant nutrient acquisition, which involves plant signaling, microbial sensing, and acquiring and sharing nutrients. In this review, we synthesize recent advancements in the complex associations of molecular, physiological, and eco-evolutionary mechanisms that underpin microbe-facilitated
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Uniting against enteric invaders: IgA meets its microbial ally Cell Host Microbe (IF 20.6) Pub Date : 2025-06-11 Sophia Adlkirchner, Romana R. Gerner
Gut colonization by opportunistic or pathogenic microbes is a critical step in infection, but strategies to displace these organisms without perturbing the commensal microbiota remain scarce. In a recent Science article, Lentsch et al. combine oral vaccination with a niche-competing strain to selectively eliminate Salmonella spp. and related Escherichia coli.
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Root bacteria hack another plant hormone and affect yield Cell Host Microbe (IF 20.6) Pub Date : 2025-06-11 Hugo R. Barajas, Derek S. Lundberg
Plant hormone pathways can be regulated by microbes. In a recent issue of Cell, Zhang et al. demonstrate manipulation of rice strigolactone signaling by root bacteria in field conditions and reveal the molecular mechanism of rhizosphere microbiota that affect rice tillering and yield.
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Rhizosphere microbes attenuate plant response to shade Cell Host Microbe (IF 20.6) Pub Date : 2025-06-11 Jigang Li, Hongtao Liu
How plants respond to shade is crucial for optimizing crop yield under high-density planting. In this issue of Cell Host & Microbe, Lu et al. revealed that rhizosphere microbes regulate shade avoidance response in Arabidopsis via the host FLS2/BAK1 immune complex and the MYC2/PIFs/HY5 transcription factors.
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Intra-phage immunity: Set a (pro)phage to catch a phage Cell Host Microbe (IF 20.6) Pub Date : 2025-06-11 Franklin L. Nobrega
In this issue, Brenes and Laub screen temperate phages for defenses against other temperate phages. This uncovers an array of prophage-encoded immune systems in E. coli. The work expands the concept of phage-phage conflict, reveals context dependency of defense, and highlights temperate phages as both targets and carriers of anti-phage immunity.
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Interferon-epsilon, an estrogen-induced type I interferon, is uniquely exploited by Neisseria gonorrhoeae via effects on sialic acid metabolism Cell Host Microbe (IF 20.6) Pub Date : 2025-06-09 Evelyn A. Kurt-Jones, Sunita Gulati, Michael King, Rosane B. de Oliveira, Peter A. Rice, Bo Zheng, Jutamas Shaughnessy, Jennifer L. Edwards, Paul J. Hertzog, Sanjay Ram, Douglas T. Golenbock
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Single-tooth resolved, whole-mouth prediction of early childhood caries via spatiotemporal variations of plaque microbiota Cell Host Microbe (IF 20.6) Pub Date : 2025-05-30 Fang Yang, Fei Teng, Yufeng Zhang, Yanfei Sun, Jian Xu, Shi Huang
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Bacteroides sphingolipids promote anti-inflammatory responses through the mevalonate pathway Cell Host Microbe (IF 20.6) Pub Date : 2025-05-30 Eric M. Brown, Emily R. Temple, Sarah Jeanfavre, Julian Avila-Pacheco, Noel Taylor, Kai Liu, Phuong N.U. Nguyen, Ahmed M.T. Mohamed, Panhasith Ung, Rebecca A. Walker, Daniel B. Graham, Clary B. Clish, Ramnik J. Xavier
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Bacteroides fragilis promotes chemoresistance in colorectal cancer, and its elimination by phage VA7 restores chemosensitivity Cell Host Microbe (IF 20.6) Pub Date : 2025-05-29 Xiao Ding, Nick Lung-Ngai Ting, Chi Chun Wong, Pingmei Huang, Lanping Jiang, Chuanfa Liu, Yufeng Lin, Shiyu Li, Yujie Liu, Mingxu Xie, Weixin Liu, Kai Yuan, Luyao Wang, Xinyue Zhang, Yanqiang Ding, Qing Li, Yang Sun, Yinglei Miao, Lanqing Ma, Xiang Gao, Weixun Li, William K.K. Wu, Joseph J.Y. Sung, Sunny Hei Wong, Jun Yu
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Drought-induced plant microbiome and metabolic enrichments improve drought resistance Cell Host Microbe (IF 20.6) Pub Date : 2025-05-29 Jiayu Li, Hongwei Liu, Juntao Wang, Catriona A. Macdonald, Pankaj Singh, Vu Thanh Cong, Marcus Klein, Manuel Delgado-Baquerizo, Brajesh K. Singh
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Targeted inhibition of pathobiont virulence factor mitigates alcohol-associated liver disease Cell Host Microbe (IF 20.6) Pub Date : 2025-05-28 Yongqiang Yang, Yi Duan, Sonja Lang, Marcos F. Fondevila, David Schöler, Aenne Harberts, Noemí Cabré, Sainan Chen, Yan Shao, Kevin Vervier, Yukiko Miyamoto, Xinlian Zhang, Huikuan Chu, Ling Yang, Chen Tan, Lars Eckmann, Francisco Bosques-Padilla, Elizabeth C. Verna, Juan G. Abraldes, Robert S. Brown Jr., Victor Vargas, Jose Altamirano, Juan Caballería, Debbie L. Shawcross, Alexandre Louvet, Michael
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Microbiota-derived urocanic acid triggered by tyrosine kinase inhibitors potentiates cancer immunotherapy efficacy Cell Host Microbe (IF 20.6) Pub Date : 2025-05-28 Mengying Zhang, Zhonghong Wei, Bin Wei, Changjie Lai, Gangfan Zong, Enxiang Tao, Minmin Fan, Yehua Pan, Bingyan Zhou, Luping Shen, Jingjing Wu, Qingqing Wang, Ying Peng, Le Zhen, Yunhao Wu, Yin Lu, Guangji Wang, Fang Zhou, Yunlong Shan
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Gut microbial enzymes and metabolic dysfunction-associated steatohepatitis: Function, mechanism, and therapeutic prospects Cell Host Microbe (IF 20.6) Pub Date : 2025-05-26 Xi Luo, Kai Wang, Changtao Jiang
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent liver disease worldwide. The liver communicates with the intestine, in large part through the gut microbiota. Microbial enzymes are key mediators that affect the progression of MASLD and the more severe metabolic dysfunction-associated steatohepatitis (MASH). These enzymes contribute to the metabolism or biosynthesis
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E. coli prophages encode an arsenal of defense systems to protect against temperate phages Cell Host Microbe (IF 20.6) Pub Date : 2025-05-22 Lucas R. Brenes, Michael T. Laub
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Rhizosphere microbes mitigate the shade avoidance responses in Arabidopsis Cell Host Microbe (IF 20.6) Pub Date : 2025-05-21 Huanhuan Lu, Caiyi Lu, Sha Huang, Wenbo Liu, Like Wang, Chuanwei Yang, Ertao Wang, Lin Li
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Deep mutational scanning of rabies glycoprotein defines mutational constraint and antibody-escape mutations Cell Host Microbe (IF 20.6) Pub Date : 2025-05-20 Arjun K. Aditham, Caelan E. Radford, Caleb R. Carr, Naveen Jasti, Neil P. King, Jesse D. Bloom
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The amazing impact of gut microbes on lifelong metabolic health Cell Host Microbe (IF 20.6) Pub Date : 2025-05-14 M.B. Geuking, C.A. Thomson
A new study published in Science1 reveals a crucial connection between our neonatal gut microbiota composition and the long-term health of our pancreas, specifically focusing on β-cell development and the subsequent lifelong impact microbe-induced β-cell expansion has on metabolic health, including prevention of, and even potential reversal of, diabetes.
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Genetic keys to microbial gut colonization Cell Host Microbe (IF 20.6) Pub Date : 2025-05-14 Karthik Anantharaman, Cody Martin
What enables certain microbes to successfully colonize the mammalian gut? In a recent issue of Cell, Liu et al. present a microbial cross-species genomic framework that identifies conserved genetic determinants of gut residency. This study provides a roadmap for developing more effective microbiome-based therapeutics, advancing our understanding of host-microbe interactions.
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Predator-prey interplay: When chemical conversation turns deadly Cell Host Microbe (IF 20.6) Pub Date : 2025-05-14 Natália Carolina Drebes Dörr, Cristina Elisa Alvarez-Martinez
Bacteria deploy many distinct mechanisms to resist protist predation in natural environments. In a recent study published in Cell, Zhang et al. discover a chemical radar used by the plant pathogen Pseudomonas syringae to sense and kill an amoeba predator.
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Decoding WEEV’s host adaptation Cell Host Microbe (IF 20.6) Pub Date : 2025-05-14 Yinong Qiu, Lei Sun
The Western equine encephalitis virus (WEEV), an alphavirus causing severe neurological disease, exhibits fluctuating epidemic patterns and enigmatic host adaptability. Recent studies by Raju et al. and Fan et al. in Cell reveal glycoprotein modifications enabling receptor switching, explaining its reduced human pathogenicity while underscoring re-emergence risks.
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RBRL co-opts NINJA for plant defense Cell Host Microbe (IF 20.6) Pub Date : 2025-05-14 Fangfang Ma, Zhilong Bao
Antiviral defense requires signal transmission that connects the perception of viral infection to activation of plant immunity. Findings in Nature by Huang et al. describe key players whereby RING1-IBR-RING2-type ubiquitin ligase (RBRL) recognizes viral coat proteins to release NINJA3-mediated suppression of jasmonate signaling and initiate broad-spectrum antiviral responses in rice.
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Unveiling strain-level dynamics in the human skin microbiome Cell Host Microbe (IF 20.6) Pub Date : 2025-05-14 Zhiming Li, Jingjing Xia, Jiucun Wang
Species-level uniformity on the skin surface masks substantial strain-level diversity modulated by ecological dynamics. In this issue of Cell Host & Microbe, Jacob et al. uncover dynamic intraspecies behaviors, revealing different patterns of colonization and persistence for two important skin commensals.
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Antibiotics fire up inflammation to cool vaccine responsiveness Cell Host Microbe (IF 20.6) Pub Date : 2025-05-14 James G. Kublin
In this issue of Cell Host & Microbe, Feng et al. find that broad-spectrum antibiotics perturbed the ecology of the gut microbiome in individuals receiving a rabies vaccine, resulting in systemic inflammatory responses. Such inflammation is hypothesized to alter immune homeostasis with consequences for immunological responsiveness to vaccination.
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A Salmonella subset exploits erythrophagocytosis to subvert SLC11A1-imposed iron deprivation Cell Host Microbe (IF 20.6) Pub Date : 2025-05-14 Béatrice Roche, Beatrice Claudi, Olivier Cunrath, Christopher K.E. Bleck, Minia Antelo-Varela, Jiagui Li, Dirk Bumann
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Age-related impairment of intestinal inflammation resolution through an eicosanoid-immune-microbiota axis Cell Host Microbe (IF 20.6) Pub Date : 2025-05-14 Marie Goepp, Jemma V. Milburn, Birong Zhang, Yijia Dong, Victoria Tyrrell, Xiaozhong Zheng, Jennifer M. Marshall, Silvia Bolsega, Marijana Basic, Laura Glendinning, Gwo-Tzer Ho, Jack Satsangi, Richard M. Breyer, Shuh Narumiya, Henry J. McSorley, Jürgen K.J. Schwarze, Christopher J. Anderson, David H. Dockrell, Adriano G. Rossi, André Bleich, Chengcan Yao
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Cohabitation facilitates microbiome shifts that promote isoflavone transformation to ameliorate liver injury Cell Host Microbe (IF 20.6) Pub Date : 2025-05-02 Yunong Zeng, Rong Wu, Yi He, Qian Zhang, Ze Wang, Ping Qin, Fangyuan Yang, Yingshi Han, Mingjing Hao, Yujian Zheng, Lei Gao, Xia Chen, Xiaoshan Zhao, Zhenhua Zeng, Zhe-Xiong Lian, Weidong Xiao, Zhanguo Liu, Zhi-Bin Zhao, Shenhai Gong
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An engineered gut bacterium protects against dietary methylmercury exposure in pregnant mice Cell Host Microbe (IF 20.6) Pub Date : 2025-05-01 Kristie B. Yu, Franciscus Chandra, Elena J. Coley-O’Rourke, Erik T. Paulson, Anna Novoselov, David Zhang, Delanie Finnigan, Jorge Paramo, Arlene Lopez-Romero, Tien S. Dong, Amina T. Schartup, Elaine Y. Hsiao
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Intraspecies dynamics underlie the apparent stability of two important skin microbiome species Cell Host Microbe (IF 20.6) Pub Date : 2025-05-01 Jacob S. Baker, Evan Qu, Christopher P. Mancuso, A. Delphine Tripp, Arolyn Conwill, Tami D. Lieberman
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An interplay between human genetics and intratumoral microbiota in the progression of colorectal cancer Cell Host Microbe (IF 20.6) Pub Date : 2025-04-29 Jing Yu, Yuxuan Liang, Qingrong Zhang, Hui Ding, Minghao Xie, Jingjing Zhang, Wenyan Hu, Sihua Xu, Yiyuan Xiao, Sha Xu, Rong Na, Baixing Wu, Jiaming Zhou, Haitao Chen
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Rhizosphere microbes facilitate the break of chlamydospore dormancy and root colonization of rice false smut fungi Cell Host Microbe (IF 20.6) Pub Date : 2025-04-29 Xiayan Pan, Yang Yue, Fengjuan Zhao, Tianqiao Song, Boting Xu, Zhi Li, Zhongqiang Qi, Junjie Yu, Huijuan Cao, Mina Yu, Qirong Shen, Jinrong Xu, Wu Xiong, Yongfeng Liu
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A bacteriophage-conditional mouse model reveals the impact of phages within a conventionally colonized gut microbiota Cell Host Microbe (IF 20.6) Pub Date : 2025-04-28 Hollyn C. Franklin, Rita Makhlouf, Anh D. Ha, Rogerio A. Bataglioli, Zachary R. Baker, Sydney A. Murphy, Hannah Jirsa, Joshua Heuler, Teresa Southard, Frank O. Aylward, Bryan B. Hsu
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Cryptosporidium modifies intestinal microvilli through an exported virulence factor Cell Host Microbe (IF 20.6) Pub Date : 2025-04-28 Elena Rodrigues, Mitchell A. Pallett, Lorian C. Straker, Tapoka T. Mkandawire, Katarzyna Sala, Lucy Collinson, Adam Sateriale
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Antibiotic-induced gut microbiome perturbation alters the immune responses to the rabies vaccine Cell Host Microbe (IF 20.6) Pub Date : 2025-04-18 Yupeng Feng, Sanne E. de Jong, Ana Paula B.N. Oliveira, Hady Samaha, Fan Yang, Mengyun Hu, Yanli Wang, Nour Beydoun, Xia Xie, Haibo Zhang, Dmitri Kazmin, Zhuoqing Fang, Jun Zou, Andrew T. Gewirtz, Scott D. Boyd, Thomas Hagan, Nadine Rouphael, Bali Pulendran
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Peptostreptococcus stomatis promotes colonic tumorigenesis and receptor tyrosine kinase inhibitor resistance by activating ERBB2-MAPK Cell Host Microbe (IF 20.6) Pub Date : 2025-04-15 Pingmei Huang, Fenfen Ji, Alvin Ho-Kwan Cheung, Kaili Fu, Qiming Zhou, Xiao Ding, Danyu Chen, Yufeng Lin, Luyao Wang, Ying Jiao, Eagle S.H. Chu, Wei Kang, Ka Fai To, Jun Yu, Chi Chun Wong
(Cell Host & Microbe 32, 1365–1379.e1–e10; August 14, 2024)
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Phyto-metabolites on guard: Role of gut microbial deglycosylation Cell Host Microbe (IF 20.6) Pub Date : 2025-04-09 Mengning Luo, Xinyang Song
Plant phenolic glycosides are thought to be beneficial for human health. In a recent issue of Cell, Kuziel et al. identified that Bacteroides species, the dominant symbiotic bacteria in the gut, harbor a unique multi-enzyme system that processes dietary plant glycosides into various aglycone metabolites with antimicrobial or immunomodulatory activities.
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Beyond MERS: Merbecovirus receptor plasticity calls for emergence preparedness Cell Host Microbe (IF 20.6) Pub Date : 2025-04-09 Jarel Elgin Tolentino, Spyros Lytras, Jumpei Ito, Kei Sato
Three studies recently published in Cell reveal distinct ACE2 binding interactions across the merbecoviruses, uncovering how HKU5 can use ACE2s of many non-human hosts and identifying a novel HKU5 lineage capable of using human ACE2. These findings highlight merbecovirus receptor plasticity and caution for preparedness against potential merbecovirus threats.
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Mucosal stargazing: IgA keeps astrovirus in check Cell Host Microbe (IF 20.6) Pub Date : 2025-04-09 Tim Rollenske
Immunoglobulin A (IgA) antibodies maintain homeostasis between the host and its microbiota, by exerting luminal control over fungi and bacteria. In this issue of Cell Host & Microbe, Lisicka et al. show that IgA antibodies also control the population of specific members of our virome.
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Interferoning with Plasmodium development in the liver Cell Host Microbe (IF 20.6) Pub Date : 2025-04-09 Justin A. Boddey, Friedrich Frischknecht
Plasmodium liver infection is limited by type I interferons (IFN-I) but the mechanisms remain unknown. In this issue of Cell Host & Microbe, Marques-da-Silva et al. reveal two IFN-I-induced pathways that trigger the fusion of lysosomes with, and the disruption of, the membranes surrounding the parasites, leading to their clearance.
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Emerging antiviral defense systems in fungi Cell Host Microbe (IF 20.6) Pub Date : 2025-04-09 Zeyu Duan, Xiao Liu
In this issue of Cell Host & Microbe, Honda et al. identify an antiviral defense system in fungi. Mycoviruses trigger the expression of RNA-editing enzymes, which catalyze the editing of mRNAs encoding zinc finger transcription factors. This system differs from the RNA interference and is conserved in filamentous fungi.
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QDS pathoblockers target and lock α-hemolysin Cell Host Microbe (IF 20.6) Pub Date : 2025-04-09 Yanan Wang, Min Li
Staphylococcus aureus is a major pathogen with rising antibiotic resistance. In this issue of Cell Host & Microbe, Shekhar et al. find that quinoxalinediones reduce S. aureus lung infections through α-hemolysin inhibition, offering a therapeutic strategy for S. aureus pneumonia.
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Engineered nasal bacteria: A new weapon against obesity? Cell Host Microbe (IF 20.6) Pub Date : 2025-04-09 Cristina Miralpeix, Daniela Cota
The nose-to-brain pathway for drug delivery holds promising therapeutic outcomes. In a recent issue of Cell, Shen et al.1 successfully identified and characterized a commensal bacterial strain to enable the intranasal delivery of therapeutics, using obesity as a disease model.
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An energetic framework for gut microbiome-mediated obesity induced by early-life exposure to antibiotics Cell Host Microbe (IF 20.6) Pub Date : 2025-04-09 Laura D. Schell, Rachel N. Carmody
Early-life antibiotic (ELA) exposure has garnered attention for its potential role in modulating obesity risk, although outcomes from mouse experiments and human epidemiological studies often vary based on dosage and sex. Low-dose (subtherapeutic) antibiotics can enhance energy availability through moderate alterations in gut microbiome profile, while high-dose (therapeutic) antibiotics substantially
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Multi-cohort analysis reveals colorectal cancer tumor location-associated fecal microbiota and their clinical impact Cell Host Microbe (IF 20.6) Pub Date : 2025-04-09 Yufeng Lin, Harry Cheuk-Hay Lau, Chuanfa Liu, Xiao Ding, Yang Sun, Jiamei Rong, Xiang Zhang, Luyao Wang, Kai Yuan, Yinglei Miao, William Ka-Kei Wu, Sunny Hei Wong, Joseph Jao-Yiu Sung, Jun Yu
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Type I interferons induce guanylate-binding proteins and lysosomal defense in hepatocytes to control malaria Cell Host Microbe (IF 20.6) Pub Date : 2025-03-31 Camila Marques-da-Silva, Clyde Schmidt-Silva, Carson Bowers, Nana Appiah Essel Charles-Chess, Cristina Samuel, Justine C. Shiau, Eui-Soon Park, Zhongyu Yuan, Bae-Hoon Kim, Dennis E. Kyle, John T. Harty, John D. MacMicking, Samarchith P. Kurup
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Highly potent quinoxalinediones inhibit α-hemolysin and ameliorate Staphylococcus aureus lung infections Cell Host Microbe (IF 20.6) Pub Date : 2025-03-31 Aditya Shekhar, Raffaella Di Lucrezia, Karoline Jerye, Vadim S. Korotkov, Kirsten Harmrolfs, Katharina Rox, Herbert A. Weich, Ishan Ghai, Florent Delhommel, Isabelle Becher, Carsten Degenhart, Eyad Fansa, Anke Unger, Peter Habenberger, Bert Klebl, Peer Lukat, Stefan Schmelz, Steffi Henke, Sebastian Borgert, Julia C. Lang, Florenz Sasse, Randi Diestel, Clémentine Richter, Nicole Schneider-Daum, Bettina
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Sequential membrane- and protein-bound organelles compartmentalize genomes during phage infection Cell Host Microbe (IF 20.6) Pub Date : 2025-03-31 Emily G. Armbruster, Phoolwanti Rani, Jina Lee, Niklas Klusch, Joshua Hutchings, Lizbeth Y. Hoffman, Hannah Buschkaemper, Eray Enustun, Benjamin A. Adler, Koe Inlow, Arica R. VanderWal, Madelynn Y. Hoffman, Daksh Daksh, Ann Aindow, Amar Deep, Zaida K. Rodriguez, Chase J. Morgan, Majid Ghassemian, Thomas G. Laughlin, Emeric Charles, Brady F. Cress, David F. Savage, Jennifer A. Doudna, Kit Pogliano,
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Immunoglobulin A controls intestinal virus colonization to preserve immune homeostasis Cell Host Microbe (IF 20.6) Pub Date : 2025-03-27 Wioletta Lisicka, Zachary M. Earley, Joseph J. Sifakis, Steven A. Erickson, Jonathan R. Mattingly, Natalie J. Wu-Woods, Siddharth R. Krishnamurthy, Yasmine Belkaid, Rustem F. Ismagilov, Jason G. Cyster, Samantha J. Riesenfeld, Albert Bendelac, Bana Jabri
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A thiouracil desulfurase protects Clostridioides difficile RNA from 4-thiouracil incorporation, providing a competitive advantage in the gut Cell Host Microbe (IF 20.6) Pub Date : 2025-03-25 Matthew J. Munneke, Yifeng Yuan, Eva C. Preisner, Catherine D. Shelton, Darian T. Carroll, Nicole S. Kirchoff, Ken P. Dickson, Jose O. Cantu, Martin V. Douglass, M. Wade Calcutt, Katherine N. Gibson-Corley, Maribeth R. Nicholson, Mariana X. Byndloss, Robert A. Britton, Valérie de Crécy-Lagard, Eric P. Skaar
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Transcriptional repressor Capicua is a gatekeeper of cell-intrinsic interferon responses Cell Host Microbe (IF 20.6) Pub Date : 2025-03-24 Senthamizharasi Manivasagam, Julianna Han, Athmane Teghanemt, Henry Keen, Boopathi Sownthirarajan, Boyang Cheng, Abhiraj Singh, Abigail Lewis, Olivia A. Vogel, Gayathri Loganathan, Lei Huang, Maryline Panis, David K. Meyerholz, Benjamin tenOever, Jasmine T. Perez, Santhakumar Manicassamy, Priya D. Issuree, Balaji Manicassamy
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RNA editing of genomic neighbors controls antiviral response in fungi Cell Host Microbe (IF 20.6) Pub Date : 2025-03-24 Shinji Honda, Ayumi Yokoyama, Nobuhiro Suzuki
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Boosting endosymbiosis in plants for future self-sustained crop production Cell Host Microbe (IF 20.6) Pub Date : 2025-03-12 Ariane Kemen, Eric Kemen
In a recent article in Nature, Cook et al. demonstrate that an autoactive mutant of CNGC15 generates continuous low-frequency calcium (Ca2+) oscillations, enabling sustained flavonoid production and promoting endosymbiont attraction and root colonization. The mutant simultaneously enables endosymbiosis gene induction, even under high-nutrient conditions, offering avenues for improving crop-microbe
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METs, NETs, and UTIs Cell Host Microbe (IF 20.6) Pub Date : 2025-03-12 Thomas J. Hannan
The mucosal immune response of the urinary bladder to bacterial infection is complex, as immune cells must efficiently neutralize and contain the infection while preventing harmful pathology. A recent Immunity paper by Li et al. illuminates the critical role of a resident macrophage subset in preventing invasive and life-threatening disease.