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A human gut bacterium antagonizes neighboring bacteria by altering their protein-folding ability Cell Host Microbe (IF 20.6) Pub Date : 2025-02-04 Bentley Lim, Jinghua Xu, Igor H. Wierzbicki, Carlos G. Gonzalez, Zhe Chen, David J. Gonzalez, Xiang Gao, Andrew L. Goodman
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Rare twin cysteine residues in the HIV-1 envelope variable region 1 link to neutralization escape and breadth development Cell Host Microbe (IF 20.6) Pub Date : 2025-02-04 Maria C. Hesselman, Marius Zeeb, Peter Rusert, Chloé Pasin, Jennifer Mamrosh, Samuel Kariuki, Ian Pichler, Michèle Sickmann, Masako M. Kaufmann, Daniel Schmidt, Nikolas Friedrich, Karin J. Metzner, Audrey Rindler, Herbert Kuster, Craig Adams, Ruwayhida Thebus, Michael Huber, Sabine Yerly, Karoline Leuzinger, Matthieu Perreau, Alexandra Trkola
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Competitive behaviors in Serratia marcescens are coordinately regulated by a lifestyle switch frequently inactivated in the clinical environment Cell Host Microbe (IF 20.6) Pub Date : 2025-01-29 David J. Williams, Alexandra Hawkins, Ruth E. Hernandez, Giuseppina Mariano, Katharine Mathers, Grant Buchanan, Barnaby J. Stonier, Teresa Inkster, Alistair Leanord, James D. Chalmers, Nicholas R. Thomson, Matthew T.G. Holden, Sarah J. Coulthurst
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Fiber- and acetate-mediated modulation of MHC-II expression on intestinal epithelium protects from Clostridioides difficile infection Cell Host Microbe (IF 20.6) Pub Date : 2025-01-17 José L. Fachi, Sarah de Oliveira, Tihana Trsan, Silvia Penati, Susan Gilfillan, Siyan Cao, Pollyana Ribeiro Castro, Mariane Font Fernandes, Krzysztof L. Hyrc, Xiuli Liu, Patrick Fernandes Rodrigues, Bishan Bhattarai, Brian T. Layden, Marco Aurélio R. Vinolo, Marco Colonna
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Decoding the blueprint of receptor binding by filoviruses through large-scale binding assays and machine learning Cell Host Microbe (IF 20.6) Pub Date : 2025-01-15 Gorka Lasso, Michael Grodus, Estefania Valencia, Veronica DeJesus, Eliza Liang, Isabel Delwel, Rob H. Bortz III, Dmitry Lupyan, Hanna Y. Ehrlich, Adrian A. Castellanos, Andrea Gazzo, Heather L. Wells, Supaporn Wacharapluesadee, Alexandre Tremeau-Bravard, Janine F.R. Seetahal, Tom Hughes, Jimmy Lee, Mei-Ho Lee, Anna R. Sjodin, Marike Geldenhuys, Marinda Mortlock, Isamara Navarrete-Macias, Kirsten Gilardi
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MFSD6 is an entry receptor for respiratory enterovirus D68 Cell Host Microbe (IF 20.6) Pub Date : 2025-01-10 Xize Liu, Huili Li, Zhaoxue Li, Delong Gao, Junfeng Zhou, Fushun Ni, Qing Yu, Yuehan Huang, Yubin Tang, Ling Xue, Shijin Wang, Jiaxin Yang, Haoran Guo, Yonggang Wang, Xiao-Fang Yu, Zhenglei Yu, Wei Wei
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pks+E. coli adhesins—The fine line between good and evil Cell Host Microbe (IF 20.6) Pub Date : 2025-01-08 Chi Chun Wong, Jun Yu
Gut bacteria could promote colorectal cancer by generating genotoxins. In a recent issue of Nature, Jans et al. identified bacterial adhesion as an additional determinant for the genotoxic activity of colibactin-producing E. coli on the colon epithelium, which could be targeted to mitigate bacteria-associated DNA damage.
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The butterfly effect of the strain richness influences the efficacy of microbiota transplantation Cell Host Microbe (IF 20.6) Pub Date : 2025-01-08 Weihong Wang, Zheshun Pi, You Yu, Faming Zhang
Strain-level variation in the gut microbiome modulates its impact on host health. Recently in Nature, Chen-Liaw et al. propose that strain richness is a crucial element in the gut ecosystem, thus influencing efficacy of fecal microbiota transplantation, and provide a theoretical foundation for optimizing microbiota-based treatments and developing microbiota medicine.
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Commensal fungi, a force to be reckoned with Cell Host Microbe (IF 20.6) Pub Date : 2025-01-08 Dingjiacheng Jia, Shujie Chen
Fungal symbionts play a key role in maintaining host homeostasis. In a recent issue of Nature, Liao et al. show that Kazachstania pintolopesii, a symbiotic fungus in mice, is shielded from the host immune system during homeostasis but induces type 2 immunity during mucus fluctuations.
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Cad1 turns ATP into phage poison Cell Host Microbe (IF 20.6) Pub Date : 2025-01-08 Jinzhong Lin, Yuvaraj Bhoobalan-Chitty, Xu Peng
Type III CRISPR-Cas executes a multifaceted anti-phage response, activating effectors such as a nuclease or membrane depolarizer. In a recent Cell paper, Baca and Majumder et al.1 report an accessory effector, Cad1, which deaminates ATP into ITP, causing ITP accumulation and host growth arrest, thereby inhibiting phage propagation.
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Exploring the open (host) range Cell Host Microbe (IF 20.6) Pub Date : 2025-01-08 David A. Baltrus, Brian H. Kvitko
The report from Grenz et al. in the latest issue of Cell Host & Microbe demonstrates how incorporation of phenotypic, genetic, genomic, and evolutionary information into experimental design provides a more complete picture than focusing on single host-pathogen relationships.
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Linking E. coli to fibrosis in Crohn’s disease Cell Host Microbe (IF 20.6) Pub Date : 2025-01-08 Ethan T. Dehantschutter, Cormac T. Taylor
Intestinal fibrosis associated with Crohn’s disease is a serious yet poorly understood clinical complication. In this issue of Cell Host & Microbe, Ahn and colleagues provide evidence that the adherent intestinal E. coli produced the metallophore yersiniabactin, which sequesters zinc to drive intestinal fibrosis in a HIF-1α-dependent manner.
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Bugs take the sting out Cell Host Microbe (IF 20.6) Pub Date : 2025-01-08 Arren J. Liu, Jonathan B. Lynch
Jiang et al. investigate the role of the microbiota in postherpetic neuralgia (PHN), a chronic pain condition resulting from varicella-zoster virus reactivation. They identify microbiome alterations in PHN patients, linking microbes and pain sensitivity. The researchers identify butyrate-producing Roseburia intestinalis as a mediator of pain sensitivity along the “gut-brain axis.”
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Fungal influence: The role of the gut mycobiome in women’s health Cell Host Microbe (IF 20.6) Pub Date : 2025-01-08 Tian-Yi Zhang, Ning-Ning Liu
In this issue of Cell Host & Microbe, Wu et al. identified enriched gut Aspergillus tubingensis in patients with polycystic ovary syndrome (PCOS). In mice, this fungus induced a PCOS-like phenotype by inhibiting interleukin (IL)-22 secretion from ILC3s via the AT-C1-AhR axis. PCOS, a women’s health concern, is influenced by the gut mycobiome.
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Clec12a controls colitis by tempering inflammation and restricting expansion of specific commensals Cell Host Microbe (IF 20.6) Pub Date : 2025-01-08 Tyson R. Chiaro, Morgan Greenewood, Kaylyn M. Bauer, Kyla S. Ost, Emmanuel Stephen-Victor, Michaela Murphy, Allison M. Weis, Morgan C. Nelson, Jennifer H. Hill, Rickesha Bell, Warren Voth, Taylor Jackson, Kendra A. Klag, Ryan M. O’Connell, W. Zac Stephens, June L. Round
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The intestinal fungus Aspergillus tubingensis promotes polycystic ovary syndrome through a secondary metabolite Cell Host Microbe (IF 20.6) Pub Date : 2025-01-08 Jiayu Wu, Kai Wang, Xinyu Qi, Shuang Zhou, Shuyun Zhao, Meisong Lu, Qixing Nie, Meng Li, Mengwei Han, Xi Luo, Chuyu Yun, Pengcheng Wang, Rong Li, Chao Zhong, Xiaofei Yu, Wen-bing Yin, Changtao Jiang, Jie Qiao, Yanli Pang
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Identification of a broad-inhibition influenza neuraminidase antibody from pre-existing memory B cells Cell Host Microbe (IF 20.6) Pub Date : 2024-12-30 Xin Wang, Huihui Kong, Bingxin Chu, Qian Yang, Chaohui Lin, Rui Liu, Changxu Chen, Yang Gao, Guojun Wang, Dayan Wang, Chen Qin, Xiaohua Ye, Lifei Yu, Xiangfei Xu, Jie Jin, Ren Sun, Hualan Chen, Xudong Wu, Zeli Zhang
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The blue-light receptor CRY1 serves as a switch to balance photosynthesis and plant defense Cell Host Microbe (IF 20.6) Pub Date : 2024-12-27 Yuhan Hao, Zexian Zeng, Minhang Yuan, Hui Li, Shisong Guo, Yu Yang, Shushu Jiang, Eva Hawara, Jianxu Li, Peng Zhang, Jiawei Wang, Xiufang Xin, Wenbo Ma, Hongtao Liu
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Commensal-pathogen dynamics structure disease outcomes during Clostridioides difficile colonization Cell Host Microbe (IF 20.6) Pub Date : 2024-12-27 Skye R.S. Fishbein, Anna L. DeVeaux, Sakshi Khanna, Aura L. Ferreiro, James Liao, Wesley Agee, Jie Ning, Bejan Mahmud, Miranda J. Wallace, Tiffany Hink, Kimberly A. Reske, Candice Cass, Janaki Guruge, Sidh Leekha, Sunaina Rengarajan, Erik R. Dubberke, Gautam Dantas
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Phocaeicola vulgatus shapes the long-term growth dynamics and evolutionary adaptations of Clostridioides difficile Cell Host Microbe (IF 20.6) Pub Date : 2024-12-26 Jordy Evan Sulaiman, Jaron Thompson, Pak Lun Kevin Cheung, Yili Qian, Jericha Mill, Isabella James, Hanhyeok Im, Eugenio I. Vivas, Judith Simcox, Ophelia S. Venturelli
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A necrotizing toxin enables Pseudomonas syringae infection across evolutionarily divergent plants Cell Host Microbe (IF 20.6) Pub Date : 2024-12-19 Kristina Grenz, Khong-Sam Chia, Emma K. Turley, Alexa S. Tyszka, Rebecca E. Atkinson, Jacob Reeves, Martin Vickers, Martin Rejzek, Joseph F. Walker, Philip Carella
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Roseburia intestinalis-derived butyrate alleviates neuropathic pain Cell Host Microbe (IF 20.6) Pub Date : 2024-12-19 Yanjun Jiang, Ziheng Huang, Wuping Sun, Jiabin Huang, Yunlong Xu, Yuliang Liao, Tingting Jin, Qing Li, Idy Hiu Ting Ho, Yidan Zou, Wenyi Zhu, Qian Li, Fenfen Qin, Xinyi Zhang, Shuqi Shi, Na Zhang, Shaomin Yang, Wenhui Xie, Songbin Wu, Likai Tan, Lin Zhang, Huarong Chen, Tony Gin, Matthew Tak Vai Chan, William Ka Kei Wu, Lizu Xiao, Xiaodong Liu
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Intestinal E. coli-produced yersiniabactin promotes profibrotic macrophages in Crohn’s disease Cell Host Microbe (IF 20.6) Pub Date : 2024-12-18 Ju-Hyun Ahn, Marlus da Silva Pedrosa, Lacey R. Lopez, Taylor N. Tibbs, Joanna N. Jeyachandran, Emily E. Vignieri, Aaron Rothemich, Ian Cumming, Alexander D. Irmscher, Corey J. Haswell, William C. Zamboni, Yen-Rei A. Yu, Melissa Ellermann, Lee A. Denson, Janelle C. Arthur
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Fungal-bacterial endosymbiosis: Recreating an ancient symbiotic relationship Cell Host Microbe (IF 20.6) Pub Date : 2024-12-11 Paola Bonfante
Fungal-bacterial endosymbioses, the most intimate typology of symbioses, have been described in different taxa of Mucoromycota, an early diverging group of Fungi. In a recent issue of Nature, Giger and colleagues describe how they implanted a Burkolderia-related microbe inside a Mucoromycota fungus, giving rise to a functional and stable endosymbiosis.
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Guilds as guides for health vs. disease Cell Host Microbe (IF 20.6) Pub Date : 2024-12-11 Antonio L.C. Gomes, Robert R. Jenq
In a recent Cell paper, Wu et al. identified microbiome guilds based on bacterial co-occurrence among type 2 diabetes patients. Two competing guilds, associated with high-fiber vs. control diets, correlated with healthy biomarkers. The potential of this approach was further verified across 15 diseases in 26 studies.
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HAMpering infection: Helicase ratcheting emerges as a phage-sensing mechanism Cell Host Microbe (IF 20.6) Pub Date : 2024-12-11 Zhifeng Zeng, Wenyuan Han
The sensing of pathogens is the first step for any immune response. A recent paper in Cell reveals that the bacterial Hachiman anti-phage defense system deploys a helicase subunit to sense phage invasion via 3′ DNA recognition and subsequent domain rotation to enable nuclease activation.
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The bad neighbor: Prophage competition in Salmonella during macrophage infection Cell Host Microbe (IF 20.6) Pub Date : 2024-12-11 Zoe Netter
Sargen and Helaine discover a prophage competition element in Salmonella that inhibits the lytic cycle of co-resident prophages by cleaving a subset of cellular tRNAs. During Salmonella pathogenesis in macrophages, a persister subset experiences prophage induction and competition, reducing release of immunogenic cellular components and altering macrophage response to infection.
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Selenium nanoboosting of plant-beneficial microbiome Cell Host Microbe (IF 20.6) Pub Date : 2024-12-11 Miaomiao Ding, Ivie Sonia Osayande, Kenichi Tsuda
In the dynamic theater of plant-microbe interactions, a new conductor has emerged: selenium nanoparticles. As unveiled by Sun et al. in this issue of Cell Host & Microbe, these microbially synthesized nanoparticles recruit plant growth-promoting microbes, orchestrating a synergy between plants and the rhizosphere microbiome.
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Exploring the early life gut microbiome with MAGIC Cell Host Microbe (IF 20.6) Pub Date : 2024-12-11 Edoardo Pasolli
In this issue of Cell Host & Microbe, Peng et al. provide the MAGIC catalog as a resource for studying bacterial and viral diversity of the global gut microbiome in early life. By addressing gaps in geographic and age representation, this database enhances our understanding of early microbiome dynamics.
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Type I IFN-mediated NET release promotes Mycobacterium tuberculosis replication and is associated with granuloma caseation Cell Host Microbe (IF 20.6) Pub Date : 2024-12-04 Chanchal Sur Chowdhury, Rachel L. Kinsella, Michael E. McNehlan, Sumanta K. Naik, Daniel S. Lane, Priyanka Talukdar, Asya Smirnov, Neha Dubey, Ananda N. Rankin, Samuel R. McKee, Reilly Woodson, Abigail Hii, Sthefany M. Chavez, Darren Kreamalmeyer, Wandy Beatty, Joshua T. Mattila, Christina L. Stallings
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Cas10 relieves host growth arrest to facilitate spacer retention during type III-A CRISPR-Cas immunity Cell Host Microbe (IF 20.6) Pub Date : 2024-12-02 Naama Aviram, Amanda K. Shilton, Nia G. Lyn, Bernardo S. Reis, Amir Brivanlou, Luciano A. Marraffini
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Campylobacter jejuni-derived cytolethal distending toxin promotes colorectal cancer metastasis Cell Host Microbe (IF 20.6) Pub Date : 2024-12-02 Zhen He, Jing Yu, Junli Gong, Jinjie Wu, Xuan Zong, Zhanhao Luo, Xiaowen He, Wai Ming Cheng, Yugeng Liu, Chen Liu, Qiang Zhang, Lei Dai, Tao Ding, Beile Gao, Raad Z. Gharaibeh, Jinlin Huang, Christian Jobin, Ping Lan
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Persistence of spike protein at the skull-meninges-brain axis may contribute to the neurological sequelae of COVID-19 Cell Host Microbe (IF 20.6) Pub Date : 2024-11-29 Zhouyi Rong, Hongcheng Mai, Gregor Ebert, Saketh Kapoor, Victor G. Puelles, Jan Czogalla, Senbin Hu, Jinpeng Su, Danilo Prtvar, Inderjeet Singh, Julia Schädler, Claire Delbridge, Hanno Steinke, Hannah Frenzel, Katja Schmidt, Christian Braun, Gina Bruch, Viktoria Ruf, Mayar Ali, Kurt-Wolfram Sühs, Mojtaba Nemati, Franziska Hopfner, Selin Ulukaya, Denise Jeridi, Daniele Mistretta, Özüm Sehnaz Caliskan
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Protection against Clostridioides difficile disease by a naturally avirulent strain Cell Host Microbe (IF 20.6) Pub Date : 2024-11-27 Qiwen Dong, Stephen Harper, Emma McSpadden, Sophie S. Son, Marie-Maude Allen, Huaiying Lin, Rita C. Smith, Carolyn Metcalfe, Victoria Burgo, Che Woodson, Anitha Sundararajan, Amber Rose, Mary McMillin, David Moran, Jessica Little, Michael W. Mullowney, Ashley M. Sidebottom, Louis-Charles Fortier, Aimee Shen, Eric G. Pamer
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Zinc promotes microbial p-coumaric acid production that protects against cholestatic liver injury Cell Host Microbe (IF 20.6) Pub Date : 2024-11-27 Dongping Li, Meijuan Wan, Lanfeng Xue, Zhelin Zhang, Yifeng Qiu, Fengyi Mei, Niexing Tang, Chunxiao Yu, Yao Yu, Tianqi Chen, Xing Ding, Qin Yang, Qiuyan Liu, Peng Gu, Wei Jia, Yu Chen, Peng Chen
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Prenatal antibiotics reduce breast milk IgA and induce dysbiosis in mouse offspring, increasing neonatal susceptibility to bacterial sepsis Cell Host Microbe (IF 20.6) Pub Date : 2024-11-26 Carlo Pietrasanta, Carolina Carlosama, Michela Lizier, Giulia Fornasa, Tanja Rezzonico Jost, Sara Carloni, Silvia Giugliano, Alessandra Silvestri, Paola Brescia, Benedetta De Ponte Conti, Daniele Braga, Martin Mihula, Lavinia Morosi, Alessandro Bernardinello, Andrea Ronchi, Giuseppe Martano, Fabio Mosca, Giuseppe Penna, Fabio Grassi, Lorenza Pugni, Maria Rescigno
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A nucleoside signal generated by a fungal endophyte regulates host cell death and promotes root colonization Cell Host Microbe (IF 20.6) Pub Date : 2024-11-26 Nick Dunken, Heidi Widmer, Gerd U. Balcke, Henryk Straube, Gregor Langen, Nyasha M. Charura, Pia Saake, Concetta De Quattro, Jonas Schön, Hanna Rövenich, Stephan Wawra, Mamoona Khan, Armin Djamei, Matias D. Zurbriggen, Alain Tissier, Claus-Peter Witte, Alga Zuccaro
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A metagenome-assembled genome inventory for children reveals early-life gut bacteriome and virome dynamics Cell Host Microbe (IF 20.6) Pub Date : 2024-11-25 Ye Peng, Jie Zhu, Shilan Wang, Yingzhi Liu, Xin Liu, Orlando DeLeon, Wenyi Zhu, Zhilu Xu, Xi Zhang, Shilin Zhao, Suisha Liang, Hang Li, Brian Ho, Jessica Yuet-Ling Ching, Chun Pan Cheung, Ting Fan Leung, Wing Hung Tam, Tak Yeung Leung, Eugene B. Chang, Francis Ka Leung Chan, Lin Zhang, Siew Chien Ng, Hein Min Tun
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Harnessing biosynthesized selenium nanoparticles for recruitment of beneficial soil microbes to plant roots Cell Host Microbe (IF 20.6) Pub Date : 2024-11-18 Chenyu Sun, Bin Sun, Lin Chen, Meilin Zhang, Pingping Lu, Mengfan Wu, Quanhong Xue, Qiao Guo, Dejian Tang, Hangxian Lai
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A trivalent mucosal vaccine encoding phylogenetically inferred ancestral RBD sequences confers pan-Sarbecovirus protection in mice Cell Host Microbe (IF 20.6) Pub Date : 2024-11-18 James Brett Case, Shilpa Sanapala, Carly Dillen, Victoria Rhodes, Christian Zmasek, Taras M. Chicz, Charlotte E. Switzer, Suzanne M. Scheaffer, George Georgiev, Catherine Jacob-Dolan, Blake M. Hauser, Déborah Carolina Carvalho Dos Anjos, Lucas J. Adams, Nadia Soudani, Chieh-Yu Liang, Baoling Ying, Ryan P. McNamara, Richard H. Scheuermann, Adrianus C.M. Boon, Daved H. Fremont, Sean P.J. Whelan, Aaron
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If you can’t beat them, join them: Anti-CRISPR proteins derived from CRISPR-associated genes Cell Host Microbe (IF 20.6) Pub Date : 2024-11-13 Charlie Y. Mo
Bacteriophages have evolved numerous mechanisms to evade targeting by CRISPR-Cas defense systems. However, the evolutionary origin of these so-called “anti-CRISPRs” remains poorly understood. In a recent issue of Nature, Katz et al.1 provide evidence that some anti-CRISPRs were derived from genes of the CRISPR-Cas systems themselves.
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Beta-carbolines suppress vaginal inflammation Cell Host Microbe (IF 20.6) Pub Date : 2024-11-13 Cancan Qi, Ri-hua Xie, Yan He, Muxuan Chen
Vaginal lactobacilli are key regulators of host inflammation, yet the mechanisms remain understudied. In this issue of Cell Host & Microbe, Glick et al. identify a family of beta-carbolines as anti-inflammatory effectors produced by vaginal Lactobacillus species, highlighting their potential as therapeutics for vaginal inflammatory disorders.
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Bacterial small RNA makes a big impact for gut colonization Cell Host Microbe (IF 20.6) Pub Date : 2024-11-13 Elena Monzel, Mahesh S. Desai
The functions of non-coding small RNAs (sRNAs) within the human microbiome remain largely unexplored. In this Cell Host & Microbe issue, El Mouali et al. identify Segatella RNA colonization factor (SrcF), a sRNA from a prevalent gut bacterium Segatella copri. SrcF promotes colonization of S. copri by regulating bacterial degradation of complex dietary carbohydrates.
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Microbial alchemists unlock honeybee cognition Cell Host Microbe (IF 20.6) Pub Date : 2024-11-13 Huihui Sun, Guan-Hong Wang
In this issue of Cell Host & Microbe, Zhong et al.1 uncover gut microbiota-host connections that promote cognitive function in honeybees. They discover the role of the microbiota in lipid metabolism and the synthesis of lipid-derived neurotransmitters, which modulate the endocannabinoid system.
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A small microcin plays a big role in V. cholerae interbacterial competition Cell Host Microbe (IF 20.6) Pub Date : 2024-11-13 Wei Peng, Kim Orth
Microcins are antibacterial small proteins secreted by gram-negative bacteria. In this issue of Cell Host & Microbe, Kim et al. report the discovery of a V. cholerae microcin, MvcC. MvcC shows antibacterial activity against non-self V. cholerae strains, which do not encode the cognate immunity protein.
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INDELible impact: How structural variants drive virulence and resistance Cell Host Microbe (IF 20.6) Pub Date : 2024-11-13 Alexandra Grote
Tuberculosis remains a formidable global health challenge, with Mycobacterium tuberculosis responsible for millions of cases and deaths annually. In this issue of Cell Host & Microbe, Worakitchanon et al. present a method to identify structural variants in Mtb and explore associations with bacterial phenotypes such as virulence and antibiotic resistance.
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mRNA vaccines: A promising platform for safer, more effective next-generation Orthopoxvirus immunization Cell Host Microbe (IF 20.6) Pub Date : 2024-11-13 Xiaonan Han, Qingrui Huang, Jinghua Yan
In recent work, Mucker et al.1 demonstrated that mRNA-1769 outperforms modified vaccinia Ankara (MVA), which has been deployed against recent mpox virus (MPXV) outbreaks, in reducing clinical symptoms and controlling viral replication, highlighting its potential as a scalable, safe, and effective next-generation platform for orthopoxvirus vaccination.
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Microbiota-induced alteration of kynurenine metabolism in macrophages drives formation of creeping fat in Crohn’s disease Cell Host Microbe (IF 20.6) Pub Date : 2024-11-13 Jinjie Wu, Wanyi Zeng, Hongyu Xie, Mujia Cao, Jingyi Yang, Yanchun Xie, Zhanhao Luo, Zongjin Zhang, Haoyang Xu, Weidong Huang, Tingyue Zhou, Jinyu Tan, Xiaomin Wu, Zihuan Yang, Shu Zhu, Ren Mao, Zhen He, Ping Lan
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A prophage competition element protects Salmonella from lysis Cell Host Microbe (IF 20.6) Pub Date : 2024-11-07 Molly R. Sargen, Sophie Helaine
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Longitudinal analysis of the gut microbiota during anti-PD-1 therapy reveals stable microbial features of response in melanoma patients Cell Host Microbe (IF 20.6) Pub Date : 2024-10-30 Angeli D.G. Macandog, Carlotta Catozzi, Mariaelena Capone, Amir Nabinejad, Padma P. Nanaware, Shujing Liu, Smita Vinjamuri, Johanna A. Stunnenberg, Serena Galiè, Maria Giovanna Jodice, Francesca Montani, Federica Armanini, Ester Cassano, Gabriele Madonna, Domenico Mallardo, Benedetta Mazzi, Salvatore Pece, Maria Tagliamonte, Vito Vanella, Massimo Barberis, Luigi Nezi
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Comprehensive analysis of Mycobacterium tuberculosis genomes reveals genetic variations in bacterial virulence Cell Host Microbe (IF 20.6) Pub Date : 2024-10-28 Wittawin Worakitchanon, Hideki Yanai, Pundharika Piboonsiri, Reiko Miyahara, Supalert Nedsuwan, Worarat Imsanguan, Boonchai Chaiyasirinroje, Waritta Sawaengdee, Sukanya Wattanapokayakit, Nuanjan Wichukchinda, Yosuke Omae, Prasit Palittapongarnpim, Katsushi Tokunaga, Surakameth Mahasirimongkol, Akihiro Fujimoto
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Metatranscriptomics-guided discovery and characterization of a polyphenol-metabolizing gut microbial enzyme Cell Host Microbe (IF 20.6) Pub Date : 2024-10-28 Minwoo Bae, Chi Le, Raaj S. Mehta, Xueyang Dong, Lindsey M. Pieper, Lorenzo Ramirez, Margaret Alexander, Sina Kiamehr, Peter J. Turnbaugh, Curtis Huttenhower, Andrew T. Chan, Emily P. Balskus
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Exclusive enteral nutrition initiates individual protective microbiome changes to induce remission in pediatric Crohn’s disease Cell Host Microbe (IF 20.6) Pub Date : 2024-10-25 Deborah Häcker, Kolja Siebert, Byron J. Smith, Nikolai Köhler, Alessandra Riva, Aritra Mahapatra, Helena Heimes, Jiatong Nie, Amira Metwaly, Hannes Hölz, Quirin Manz, Federica De Zen, Jeannine Heetmeyer, Katharina Socas, Giang Le Thi, Chen Meng, Karin Kleigrewe, Josch K. Pauling, Klaus Neuhaus, Markus List, Dirk Haller
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Vaginal lactobacilli produce anti-inflammatory β-carboline compounds Cell Host Microbe (IF 20.6) Pub Date : 2024-10-17 Virginia J. Glick, Cecilia A. Webber, Lauren E. Simmons, Morgan C. Martin, Maryam Ahmad, Cecilia H. Kim, Amanda N.D. Adams, Sunghee Bang, Michael C. Chao, Nicole C. Howard, Sarah M. Fortune, Manasvi Verma, Marco Jost, Lalit K. Beura, Michael J. James, Seo Yoon Lee, Caroline M. Mitchell, Jon Clardy, Ki Hyun Kim, Smita Gopinath
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Gut symbiont-derived anandamide promotes reward learning in honeybees by activating the endocannabinoid pathway Cell Host Microbe (IF 20.6) Pub Date : 2024-10-16 Zhaopeng Zhong, Xiaohuan Mu, Haoyu Lang, Yueyi Wang, Yanling Jiang, Yuwen Liu, Qian Zeng, Siyuan Xia, Baotong Zhang, Zilong Wang, Xiaofei Wang, Hao Zheng
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SINE RNA of the imprinted miRNA clusters mediates constitutive type III interferon expression and antiviral protection in hemochorial placentas Cell Host Microbe (IF 20.6) Pub Date : 2024-10-12 Ishani Wickramage, Jeffrey VanWye, Klaas Max, John H. Lockhart, Ismet Hortu, Ezinne F. Mong, John Canfield, Hiran M. Lamabadu Warnakulasuriya Patabendige, Ozlem Guzeloglu-Kayisli, Kimiko Inoue, Atsuo Ogura, Charles J. Lockwood, Kemal M. Akat, Thomas Tuschl, Umit A. Kayisli, Hana Totary-Jain
(Cell Host & Microbe 31, 1185–1199.e1–e10; July 12, 2023)
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Immunity to fungi and vaccine considerations Cell Host Microbe (IF 20.6) Pub Date : 2024-10-09 Alexander J. Whitehead, Therese Woodring, Bruce S. Klein
Fungal disease poses a growing threat to public health that our current antifungal therapies are not well equipped to meet. As the population of immunocompromised hosts expands, and ecological changes favor the emergence of fungal pathogens, the development of new antifungal agents, including vaccines, becomes a global priority. Here, we summarize recent advancements in the understanding of fungal
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Gut microbiome and bladder cancer: A new link through nitrosamine metabolism Cell Host Microbe (IF 20.6) Pub Date : 2024-10-09 Sridhar Mani
A recent Nature paper1 reveals that gut microbes metabolize N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) into the bladder carcinogen N-n-butyl-N-(3-carboxypropyl)-nitrosamine (BCPN) in the intestines, establishing a direct link between gut microbial activity and the development of bladder cancer.
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Bacteria renew an OLD protein to cleave host tRNAs and block phage translation Cell Host Microbe (IF 20.6) Pub Date : 2024-10-09 Kyle D. Gibbs, Michele LeRoux
Anti-phage defenses must rapidly sense and respond to diverse viruses. A recent pair of papers in Nature reveal via structural and functional assays how the PARIS defense system, a recently discovered toxin-antitoxin system, senses phage-associated molecular patterns (PhAMPs), thereby activating an endonuclease toxin that cleaves tRNA to block phage replication.
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From dysbiosis to homeostasis: Oleic acid matters in the vagina Cell Host Microbe (IF 20.6) Pub Date : 2024-10-09 Ri-hua Xie, Hao Liu, Cancan Qi, Yan He
The role of fatty acids in shaping vaginal microbiota remains unclear. In an issue of Cell, Zhu et al. use genomic and transcriptomic analyses to reveal that oleic acid (OA) selectively inhibits L. iners while promoting L. crispatus, suggesting new strategies for the treatment of bacterial vaginosis (BV).