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Cell-type-specific responses to fungal infection in plants revealed by single-cell transcriptomics Cell Host Microbe (IF 30.3) Pub Date : 2023-09-22 Bozeng Tang, Li Feng, Michelle T. Hulin, Pingtao Ding, Wenbo Ma
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Quorum sensing-activated phenylalanine metabolism drives OMV biogenesis to enhance mosquito commensal colonization resistance to Plasmodium Cell Host Microbe (IF 30.3) Pub Date : 2023-09-21 Yongmao Jiang, Han Gao, Lihua Wang, Wenqian Hu, Guandong Wang, Sibao Wang
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Impact of SARS-CoV-2 ORF6 and its variant polymorphisms on host responses and viral pathogenesis Cell Host Microbe (IF 30.3) Pub Date : 2023-09-21 Thomas Kehrer, Anastasija Cupic, Chengjin Ye, Soner Yildiz, Mehdi Bouhaddou, Nicholas A. Crossland, Erika A. Barrall, Phillip Cohen, Anna Tseng, Tolga Çağatay, Raveen Rathnasinghe, Daniel Flores, Sonia Jangra, Fahmida Alam, Ignacio Mena, Sadaf Aslam, Anjali Saqi, Magdalena Rutkowska, Manisha R. Ummadi, Giuseppe Pisanelli, Lisa Miorin
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IκBζ is an essential mediator of immunity to oropharyngeal candidiasis Cell Host Microbe (IF 30.3) Pub Date : 2023-09-18 Tiffany C. Taylor, Bianca M. Coleman, Samyuktha P. Arunkumar, Ipsita Dey, John T. Dillon, Nicole O. Ponde, Amanda C. Poholek, Daniella M. Schwartz, Mandy J. McGeachy, Heather R. Conti, Sarah L. Gaffen
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Nuclear transport receptor KA120 regulates molecular condensation of MAC3 to coordinate plant immune activation Cell Host Microbe (IF 30.3) Pub Date : 2023-09-14 Min Jia, Xuanyi Chen, Xuetao Shi, Yiling Fang, Yangnan Gu
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Say YES to single-gene lysis! Cell Host Microbe (IF 30.3) Pub Date : 2023-09-13 Ali Nabhani, Benjamin R. Morehouse
Viral strategies to lyse host microbes can sometimes involve just a single gene, although the mechanism of action can be hard to discern. In Science, Orta et al. present structures of a protein complex in which protein E of bacteriophage φX174 functions to inhibit host peptidoglycan synthesis, thereby inducing lysis.
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Fortifying immunity: PLSCR1 picks battle against SARS-CoV-2 Cell Host Microbe (IF 30.3) Pub Date : 2023-09-13 Minghua Li
Interferons (IFNs) and interferon-stimulated genes (ISGs) are the major players in the host innate immunity against viral infection. In a recent Nature paper, Xu et al. identified phospholipid scramblase 1 (PLSCR1) as a novel ISG that restricts severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection by blocking virus-cell fusion.
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MAMPs: A devil tamed becomes an angel Cell Host Microbe (IF 30.3) Pub Date : 2023-09-13 Huayuan Tang, Lin Wu
Symbiotic microorganisms modulate systemic immunity with unclear mechanisms. In this issue of Cell Host & Microbe, Clarke and colleagues uncover a coherent mechanism where the systemic spread of Firmicutes cell wall glycoconjugates enhances global immune fitness while simultaneously being delicately controlled to prevent systemic inflammation.
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Decoding the IBD paradox: A triadic interplay between REG3, enterococci, and NOD2 Cell Host Microbe (IF 30.3) Pub Date : 2023-09-13 Xiaolong He, Hongwei Zhou
In this issue of Cell Host & Microbe, Jang et al. decode an intriguing paradox: excessive antimicrobial peptide-regenerating family member 3 (REG3) expression in inflammatory bowel disease (IBD) patients depletes protective enterococci. This depletion impairs the NOD2 anti-inflammatory pathway and perpetuates inflammation, thus providing insight into IBD pathogenesis.
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Whack-a-virus: HIV-specific T cells play an exhausting game Cell Host Microbe (IF 30.3) Pub Date : 2023-09-13 Alberto Herrera, R. Brad Jones
T cell responses are important for the control of acute HIV infection but become progressively dysfunctional. In this issue of Cell Host & Microbe, Dubé et al. and Takata et al. provide insights into their ongoing interplay with persistent HIV reservoirs, with implications for harnessing functional, durable responses to eliminate HIV.
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Sex determination and transmission: Leveraging genetic screens to reveal Plasmodium’s secrets Cell Host Microbe (IF 30.3) Pub Date : 2023-09-13 Thomas Hollin, Karine G. Le Roch
Genes and regulatory mechanisms governing malaria parasite transmission and development in mosquitoes are incompletely understood. Recently, Russell and colleagues identified genes required for parasite sexual development. In this issue of Cell Host & Microbe, Ukegbu and colleagues report a genetic approach to study genes enabling parasite survival in mosquito stages.
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An active HIV reservoir during ART is associated with maintenance of HIV-specific CD8+ T cell magnitude and short-lived differentiation status Cell Host Microbe (IF 30.3) Pub Date : 2023-09-13 Hiroshi Takata, Julie L. Mitchell, Julian Pacheco, Amélie Pagliuzza, Suteeraporn Pinyakorn, Supranee Buranapraditkun, Carlo Sacdalan, Louise Leyre, Sam Nathanson, Juyeon C. Kakazu, Jintana Intasan, Peeriya Prueksakaew, Nitiya Chomchey, Nittaya Phanuphak, Mark de Souza, Elias K. Haddad, Morgane Rolland, Sodsai Tovanabutra, Sandhya Vasan, Denise C. Hsu, Lydie Trautmann
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Spontaneous HIV expression during suppressive ART is associated with the magnitude and function of HIV-specific CD4+ and CD8+ T cells Cell Host Microbe (IF 30.3) Pub Date : 2023-09-13 Mathieu Dubé, Olivier Tastet, Caroline Dufour, Gérémy Sannier, Nathalie Brassard, Gloria-Gabrielle Delgado, Amélie Pagliuzza, Corentin Richard, Manon Nayrac, Jean-Pierre Routy, Alexandre Prat, Jacob D. Estes, Rémi Fromentin, Nicolas Chomont, Daniel E. Kaufmann
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Identification of genes required for Plasmodium gametocyte-to-sporozoite development in the mosquito vector Cell Host Microbe (IF 30.3) Pub Date : 2023-09-13 Chiamaka Valerie Ukegbu, Ana Rita Gomes, Maria Giorgalli, Melina Campos, Alexander J. Bailey, Tanguy Rene Balthazar Besson, Oliver Billker, Dina Vlachou, George K. Christophides
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Widespread RNA-based cas regulation monitors crRNA abundance and anti-CRISPR proteins Cell Host Microbe (IF 30.3) Pub Date : 2023-09-01 Chao Liu, Rui Wang, Jie Li, Feiyue Cheng, Xian Shu, Huiwei Zhao, Qiong Xue, Haiying Yu, Aici Wu, Lingyun Wang, Sushu Hu, Yihan Zhang, Jun Yang, Hua Xiang, Ming Li
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Precision modulation of dysbiotic adult microbiomes with a human-milk-derived synbiotic reshapes gut microbial composition and metabolites Cell Host Microbe (IF 30.3) Pub Date : 2023-08-31 Julie E. Button, Casey M. Cosetta, Abigail L. Reens, Sarah L. Brooker, Aislinn D. Rowan-Nash, Richard C. Lavin, Russell Saur, Shuning Zheng, Chloe A. Autran, Martin L. Lee, Adam K. Sun, Amin M. Alousi, Christine B. Peterson, Andrew Y. Koh, David J. Rechtman, Robert R. Jenq, Gregory J. McKenzie
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Antimicrobial overproduction sustains intestinal inflammation by inhibiting Enterococcus colonization Cell Host Microbe (IF 30.3) Pub Date : 2023-08-30 Kyung Ku Jang, Thomas Heaney, Mariya London, Yi Ding, Gregory Putzel, Frank Yeung, Defne Ercelen, Ying-Han Chen, Jordan Axelrad, Sakteesh Gurunathan, Chaoting Zhou, Magdalena Podkowik, Natalia Arguelles, Anusha Srivastava, Bo Shopsin, Victor J. Torres, A. Marijke Keestra-Gounder, Alejandro Pironti, Matthew E. Griffin, Howard C. Hang, Ken Cadwell
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Pathogen-driven CRISPR screens identify TREX1 as a regulator of DNA self-sensing during influenza virus infection Cell Host Microbe (IF 30.3) Pub Date : 2023-08-30 Cason R. King, Yiping Liu, Katherine A. Amato, Grace A. Schaack, Clayton Mickelson, Autumn E. Sanders, Tony Hu, Srishti Gupta, Ryan A. Langlois, Judith A. Smith, Andrew Mehle
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Symbiotic Firmicutes establish mutualism with the host via innate tolerance and resistance to control systemic immunity Cell Host Microbe (IF 30.3) Pub Date : 2023-08-14 Christine K.I. Jordan, Rebecca L. Brown, Max L.Y. Larkinson, Richard P. Sequeira, Andrew M. Edwards, Thomas B. Clarke
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When microbes go missing: Understanding the impact of diversity loss within the gut microbiome Cell Host Microbe (IF 30.3) Pub Date : 2023-08-09 Daniel D. Sprockett, Katharine Z. Coyte
Two recent papers published in Cell highlight the power of both top-down and bottom-up approaches to understanding the gut microbiome. The first uses ultra-deep sequencing to identify patterns across a gradient of human industrialization, while the second uses synthetic communities to determine how strain interactions impact microbiome structure and function.
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Mycobacterial phage TM4 requires a eukaryotic-like Ser/Thr protein kinase to silence and escape anti-phage immunity Cell Host Microbe (IF 30.3) Pub Date : 2023-08-10 Xiaohui Li, Xiating Long, Liu Chen, Xiao Guo, Lining Lu, Lihua Hu, Zheng-Guo He
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Seeking old wisdoms for new AMP discovery Cell Host Microbe (IF 30.3) Pub Date : 2023-08-09 Jun Wang
In this issue of Cell Host & Microbe, Maasch et al. built a deep-learning model for proteolytic site prediction and applied this approach to modern and extinct human proteomes, revealing antimicrobial peptides. The de-extinction of archaic encrypted peptides provides a revolutionary approach for discovering functional peptides with therapeutic potential.
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Mucin-binding adhesins: A key to unlocking the door of mutualism Cell Host Microbe (IF 30.3) Pub Date : 2023-08-09 Geongoo Han, Shipra Vaishnava
From corals to mammals, mucus is a conserved feature that prevents microbes from accessing the surfaces that produce it. However, interactions between mucus and microbes remain poorly understood. In this issue of Cell Host & Microbe, Smith et al. unveil that mucus binding by bacteria is crucial for host-microbe symbiosis.
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The gut microbiome: Bridging medications and clinical outcomes post stem cell transplantation Cell Host Microbe (IF 30.3) Pub Date : 2023-08-09 Ziyu Huang, Tao Zuo
Anti-cancer therapies are usually intertwined with prolonged use of drugs, which may lead to different clinical outcomes. Recently in Cell and Cell Host & Microbe, Nguyen et al. and Vallet et al., respectively, deconvolute the drug effects on gut microbiome dynamics underpinning clinical outcomes after allogeneic hematopoietic stem cell transplantation.
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Rational design of a booster vaccine against COVID-19 based on antigenic distance Cell Host Microbe (IF 30.3) Pub Date : 2023-07-31 Ye-Fan Hu, Terrence Tsz-Tai Yuen, Hua-Rui Gong, Bingjie Hu, Jing-Chu Hu, Xuan-Sheng Lin, Li Rong, Coco Luyao Zhou, Lin-Lei Chen, Xiaolei Wang, Chaobi Lei, Thomas Yau, Ivan Fan-Ngai Hung, Kelvin Kai-Wang To, Kwok-Yung Yuen, Bao-Zhong Zhang, Hin Chu, Jian-Dong Huang
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A mucin-regulated adhesin determines the spatial organization and inflammatory character of a bacterial symbiont in the vertebrate gut Cell Host Microbe (IF 30.3) Pub Date : 2023-07-28 T. Jarrod Smith, Deepika Sundarraman, Ellie Melancon, Laura Desban, Raghuveer Parthasarathy, Karen Guillemin
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Molecular de-extinction of ancient antimicrobial peptides enabled by machine learning Cell Host Microbe (IF 30.3) Pub Date : 2023-07-28 Jacqueline R.M.A. Maasch, Marcelo D.T. Torres, Marcelo C.R. Melo, Cesar de la Fuente-Nunez
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Potent cross-neutralization of respiratory syncytial virus and human metapneumovirus through a structurally conserved antibody recognition mode Cell Host Microbe (IF 30.3) Pub Date : 2023-07-28 Xiaolin Wen, Naveenchandra Suryadevara, Nurgun Kose, Jing Liu, Xiaoyan Zhan, Laura S. Handal, Lauren E. Williamson, Andrew Trivette, Robert H. Carnahan, Theodore S. Jardetzky, James E. Crowe
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T cell reactivity to Bordetella pertussis is highly diverse regardless of childhood vaccination Cell Host Microbe (IF 30.3) Pub Date : 2023-07-24 Ricardo da Silva Antunes, Emily Garrigan, Lorenzo G. Quiambao, Sandeep Kumar Dhanda, Daniel Marrama, Luise Westernberg, Eric Wang, Adam Abawi, Aaron Sutherland, Sandra K. Armstrong, Timothy J. Brickman, John Sidney, April Frazier, Tod J. Merkel, Bjoern Peters, Alessandro Sette
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A single-nucleotide polymorphism in Helicobacter pylori promotes gastric cancer development Cell Host Microbe (IF 30.3) Pub Date : 2023-07-24 Irshad Sharafutdinov, Nicole Tegtmeyer, Bodo Linz, Manfred Rohde, Michael Vieth, Alfred Chin-Yen Tay, Binit Lamichhane, Vo Phuoc Tuan, Kartika Afrida Fauzia, Heinrich Sticht, Yoshio Yamaoka, Barry J. Marshall, Steffen Backert
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Prokaryotic Gabija complex senses and executes nucleotide depletion and DNA cleavage for antiviral defense Cell Host Microbe (IF 30.3) Pub Date : 2023-07-21 Rui Cheng, Fengtao Huang, Xueling Lu, Yan Yan, Bingbing Yu, Xionglue Wang, Bin Zhu
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Acetylation of the NS3 helicase by KAT5γ is essential for flavivirus replication Cell Host Microbe (IF 30.3) Pub Date : 2023-07-20 Taryn Serman, Cindy Chiang, GuanQun Liu, Zuberwasim Sayyad, Shanti Pandey, Meta Volcic, Haejeong Lee, Santoshi Muppala, Dhiraj Acharya, Christopher Goins, Shaun R. Stauffer, Konstantin M.J. Sparrer, Michaela U. Gack
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Circulating T cell profiles associate with enterotype signatures underlying hematological malignancy relapses Cell Host Microbe (IF 30.3) Pub Date : 2023-07-17 Nicolas Vallet, Maud Salmona, Jeanne Malet-Villemagne, Maxime Bredel, Louise Bondeelle, Simon Tournier, Séverine Mercier-Delarue, Stéphane Cassonnet, Brian Ingram, Régis Peffault de Latour, Anne Bergeron, Gérard Socié, Jérome Le Goff, Patricia Lepage, David Michonneau
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Discovery of a glutathione utilization pathway in Francisella that shows functional divergence between environmental and pathogenic species Cell Host Microbe (IF 30.3) Pub Date : 2023-07-14 Yaxi Wang, Hannah E. Ledvina, Catherine A. Tower, Stanimir Kambarev, Elizabeth Liu, James C. Charity, Lieselotte S.M. Kreuk, Qing Tang, Qiwen Chen, Larry A. Gallagher, Matthew C. Radey, Guilhem F. Rerolle, Yaqiao Li, Kelsi M. Penewit, Serdar Turkarslan, Shawn J. Skerrett, Stephen J. Salipante, Nitin S. Baliga, Joshua J. Woodward, Simon L. Dove, Joseph D. Mougous
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Eating our way to gut microbiome characterization Cell Host Microbe (IF 30.3) Pub Date : 2023-07-12
A recent study in Nature introduced an innovative ingestible device capable of collecting in situ samples from different regions of the human intestine for multi-omics analysis. This groundbreaking technology enables non-invasive and longitudinal characterization of the gut microbiome and associated metabolites.
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Multi-arming ourselves against drug-resistant bacteria Cell Host Microbe (IF 30.3) Pub Date : 2023-07-12
New classes of antibiotics are desperately needed in our fight against antibiotic-resistant bacterial infections. Jia et al. publish a new “multi-armed” antibiotic scaffold that effectively treats methicillin-resistant Staphylococcus aureus infections in mice. These compounds are structurally unlike pre-clinical or approved antibiotics, and they may hit an “irresistible” target.
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Coarse graining the human gut microbiome Cell Host Microbe (IF 30.3) Pub Date : 2023-07-12
The composition of the human gut microbiome is heterogeneous across people. However, if you squint, co-abundant microbial genera emerge, accounting for much of this ecological variability. In this issue of Cell Host & Microbe, Frioux et al. provide a workflow for identifying these bacterial guilds, or “enterosignatures.”
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Viral mimicry protects from infection when you’re expecting Cell Host Microbe (IF 30.3) Pub Date : 2023-07-12
Constitutive IFN-λ expression in the placenta protects the fetus from vertically transmitted viruses, but regulatory mechanisms are unknown. In this issue of Cell Host & Microbe, Wickramage, VanWye et al. demonstrate that Alu RNAs within a microRNA cluster important for placental development mimic viral molecular patterns to mediate protection.
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The microbial code and cancer immunotherapy outcome Cell Host Microbe (IF 30.3) Pub Date : 2023-07-12
The contribution of the gut microbiome to immune responsiveness is largely unknown. In a recent Nature Medicine article, Stein-Thoeringer et al. assess the microbiome configuration before cancer immunotherapy and determine the impact of antibiotic-masked microbial features on therapy’s effectiveness. This provides a framework for identifying microbial signatures to inform clinical strategies.
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The vagina question: Can maternal vaginal fluid impact the infant gut microbiome and neurodevelopment? Cell Host Microbe (IF 30.3) Pub Date : 2023-07-12
Cesarean section rates continue to rise globally, and C-sectioned infants are at a higher risk of adverse child outcomes. In this issue of Cell Host & Microbe, Zhou et al. report that vaginal microbial transfer (VMT) from birth mother to infant post-delivery may alter infant gut microbiota and improve neurodevelopment.
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Intestinal mucus and their glycans: A habitat for thriving microbiota Cell Host Microbe (IF 30.3) Pub Date : 2023-07-12
The colon mucus layer is organized with an inner colon mucus layer that is impenetrable to bacteria and an outer mucus layer that is expanded to allow microbiota colonization. A major component of mucus is MUC2, a glycoprotein that is extensively decorated, especially with O-glycans. In the intestine, goblet cells are specialized in controlling glycosylation and making mucus. Some microbiota members
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Multi-armed antibiotics for Gram-positive bacteria Cell Host Microbe (IF 30.3) Pub Date : 2023-07-12
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Anti-V1/V3-glycan broadly HIV-1 neutralizing antibodies in a post-treatment controller Cell Host Microbe (IF 30.3) Pub Date : 2023-07-10 Luis M. Molinos-Albert, Eduard Baquero, Mélanie Bouvin-Pley, Valérie Lorin, Caroline Charre, Cyril Planchais, Jordan D. Dimitrov, Valérie Monceaux, Matthijn Vos, , Laurent Hocqueloux, Jean-Luc Berger, Michael S. Seaman, Martine Braibant, Véronique Avettand-Fenoël, Asier Sáez-Cirión, Hugo Mouquet
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The NSP4 T492I mutation increases SARS-CoV-2 infectivity by altering non-structural protein cleavage Cell Host Microbe (IF 30.3) Pub Date : 2023-07-03 Xiaoyuan Lin, Zhou Sha, Jakob Trimpert, Dusan Kunec, Chen Jiang, Yan Xiong, Binbin Xu, Zhenglin Zhu, Weiwei Xue, Haibo Wu
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Enterosignatures define common bacterial guilds in the human gut microbiome Cell Host Microbe (IF 30.3) Pub Date : 2023-06-19 Clémence Frioux, Rebecca Ansorge, Ezgi Özkurt, Chabname Ghassemi Nedjad, Joachim Fritscher, Christopher Quince, Sebastian M. Waszak, Falk Hildebrand
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The TaxUMAP atlas: Efficient display of large clinical microbiome data reveals ecological competition in protection against bacteremia Cell Host Microbe (IF 30.3) Pub Date : 2023-06-16 Jonas Schluter, Ana Djukovic, Bradford P. Taylor, Jinyuan Yan, Caichen Duan, Grant A. Hussey, Chen Liao, Sneh Sharma, Emily Fontana, Luigi A. Amoretti, Roberta J. Wright, Anqi Dai, Jonathan U. Peled, Ying Taur, Miguel-Angel Perales, Benjamin A. Siranosian, Ami S. Bhatt, Marcel R.M. van den Brink, Eric G. Pamer, Joao B. Xavier
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Virion glycosylation influences mycobacteriophage immune recognition Cell Host Microbe (IF 30.3) Pub Date : 2023-06-16 Krista G. Freeman, Anna C. Robotham, Olivia B. Parks, Lawrence Abad, Deborah Jacobs-Sera, Michael J. Lauer, Jennifer M. Podgorski, Yu Zhang, John V. Williams, Simon J. White, John F. Kelly, Graham F. Hatfull, Welkin H. Pope
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Effects of vaginal microbiota transfer on the neurodevelopment and microbiome of cesarean-born infants: A blinded randomized controlled trial Cell Host Microbe (IF 30.3) Pub Date : 2023-06-15 Lepeng Zhou, Wen Qiu, Jie Wang, Aihua Zhao, Chuhui Zhou, Tao Sun, Ziyu Xiong, Peihua Cao, Wei Shen, Jingfen Chen, Xiaolu Lai, Liu-hong Zhao, Yue Wu, Meng Li, Feng Qiu, Yanhong Yu, Zhenjiang Zech Xu, Hongwei Zhou, Wei Jia, Yan Liao, Yan He
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Mapping the neutralizing specificity of human anti-HIV serum by deep mutational scanning Cell Host Microbe (IF 30.3) Pub Date : 2023-06-15 Caelan E. Radford, Philipp Schommers, Lutz Gieselmann, Katharine H.D. Crawford, Bernadeta Dadonaite, Timothy C. Yu, Adam S. Dingens, Julie Overbaugh, Florian Klein, Jesse D. Bloom
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COVID-19 as a catalyst for vaccine manufacturing: A South African experience Cell Host Microbe (IF 30.3) Pub Date : 2023-06-14 Penny L. Moore, Glenda Gray
COVID-19 highlighted inequitable vaccine distribution and the urgent need for vaccine manufacturing capacity on the African continent. This resulted in a burst of scientific engagement and international funding to augment capacity on the continent. However, short-term investment needs to be reinforced by a robust, strategic long-term plan to ensure sustainability.
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Lessons learned for pandemic preparedness: A collaborative network is imperative Cell Host Microbe (IF 30.3) Pub Date : 2023-06-14 Jacqueline M. Fabius, Nevan J. Krogan
The scientific community improvised to respond quickly to the SARS-CoV-2 pandemic without a template on how to work together on a global scale to understand and combat the virus. Here, we describe how we tackled impediments to success and the valuable lessons learned that prepare us for a future pandemic.
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Pregnancy-associated morbidity and mortality during pandemics: Looking to the past in order to prepare for the future Cell Host Microbe (IF 30.3) Pub Date : 2023-06-14 Allyson Caldwell, Carolyn B. Coyne
Pregnant women are at high risk of adverse outcomes in the setting of viral-associated outbreaks and pandemics. In this forum, we discuss the impact of past and current pandemics on pregnant women and make recommendations to protect this vulnerable population.
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Gut microbiota, malnutrition, and immunity: COVID-19’s confounding triad Cell Host Microbe (IF 30.3) Pub Date : 2023-06-14 Anna Creus-Cuadros, M. Mahebali Tabusi, Valeria Carpio-Arias, B. Brett Finlay
The coronavirus disease has swept the world, bringing scientists from multiple disciplines together to work on a focused cause. In this forum, we discuss different roles that microbiota, malnutrition, and immunity have on severity of coronavirus disease and the importance of studying them from a gut-systemic perspective using multi-omics approaches.
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Antiviral strategies for epidemic and pandemic preparedness Cell Host Microbe (IF 30.3) Pub Date : 2023-06-14 Dirk Jochmans, Manon Laporte, Johan Neyts
Broad(er)-acting antiviral drugs, active against entire genera or families of viruses, should be developed and stockpiled in epidemic/pandemic peacetime. They can be used to counter outbreaks as soon as the new virus has been identified and will also remain important pharmacological tools after the introduction of vaccines and monoclonal antibodies.
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The coronavirus recombination pathway Cell Host Microbe (IF 30.3) Pub Date : 2023-06-14 Heather L. Wells, Cassandra M. Bonavita, Isamara Navarrete-Macias, Blake Vilchez, Angela L. Rasmussen, Simon J. Anthony
Recombination is thought to be a mechanism that facilitates cross-species transmission in coronaviruses, thus acting as a driver of coronavirus spillover and emergence. Despite its significance, the mechanism of recombination is poorly understood, limiting our potential to estimate the risk of novel recombinant coronaviruses emerging in the future. As a tool for understanding recombination, here, we
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The role of trained immunity in COVID-19: Lessons for the next pandemic Cell Host Microbe (IF 30.3) Pub Date : 2023-06-14 Mihai G. Netea, Athanasios Ziogas, Christine Stabell Benn, Evangelos J. Giamarellos-Bourboulis, Leo A.B. Joosten, Moshe Arditi, Konstantin Chumakov, Reinout van Crevel, Robert Gallo, Peter Aaby, Jos W.M. van der Meer
Trained immunity is a long-term increase in responsiveness of innate immune cells, induced by certain infections and vaccines. During the last 3 years of the COVID-19 pandemic, vaccines that induce trained immunity, such as BCG, MMR, OPV, and others, have been investigated for their capacity to protect against COVID-19. Further, trained immunity-inducing vaccines have been shown to improve B and T cell
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Broad-spectrum pan-genus and pan-family virus vaccines Cell Host Microbe (IF 30.3) Pub Date : 2023-06-14 Chee Wah Tan, Sophie A. Valkenburg, Leo L.M. Poon, Lin-Fa Wang
Although the development and clinical application of SARS-CoV-2 vaccines during the COVID-19 pandemic demonstrated unprecedented vaccine success in a short time frame, it also revealed a limitation of current vaccines in their inability to provide broad-spectrum or universal protection against emerging variants. Broad-spectrum vaccines, therefore, remain a dream and challenge for vaccinology. This
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Bacterial molecular syringe for drug delivery Cell Host Microbe (IF 30.3) Pub Date : 2023-06-14 Sicong Lu, Yujia Cai
Different protein-delivery tools are being actively developed for efficient drug delivery into host cells. A recent study by Kreitz et al. in Nature reported a syringe-like protein delivery vector engineered from natural endosymbiotic bacteria for potential human use.
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Cracking cancer with engineered skin commensals Cell Host Microbe (IF 30.3) Pub Date : 2023-06-14 Serena Galiè, Luigi Nezi
The use of bacterial colonists as therapy carriers is gaining interest for treating cancer. In a recent publication in Science, the work by Chen et al. proposes the engineering of a commensal bacterium of the human skin microbiota to cross-present tumor antigens to T cells and counteract tumor progression.