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Functional map of SARS-CoV-2 3CL protease reveals tolerant and immutable sites Cell Host Microbe (IF 31.316) Pub Date : 2022-08-11 Sho Iketani, Seo Jung Hong, Jenny Sheng, Farideh Bahari, Bruce Culbertson, Fereshteh Fallah Atanaki, Arjun K. Aditham, Alexander F. Kratz, Maria I. Luck, Ruxiao Tian, Stephen P. Goff, Hesam Montazeri, Yosef Sabo, David D. Ho, Alejandro Chavez
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How the gut microbiota helps keep us vitaminized Cell Host Microbe (IF 31.316) Pub Date : 2022-08-10 Amber Brauer-Nikonow, Michael Zimmermann
Balanced intestinal retinoic acid concentrations are essential to maintain immune homeostasis in the gut. In this issue of Cell Host & Microbe, Bonakdar et al, sheds light on metabolic host-microbiota interactions and elegantly links diet, microbiota and host functions at the molecular level in the context of vitamin A metabolism.
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To err is human, to forgive may require different vaccines Cell Host Microbe (IF 31.316) Pub Date : 2022-08-10 C. Buddy Creech
In this issue of Cell Host & Microbe, Tsai et al. (2022) provide evidence that Staphylococcus aureus should be numbered among the pathogens for which original antigenic sin governs subsequent immune responses. Their approach may restore the utility of murine models in staphylococcal vaccine development.
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LncRNA gets into the balancing act Cell Host Microbe (IF 31.316) Pub Date : 2022-08-10 Feng Li, Jacob O. Brunkard, Barbara Baker
The plant hormone salicylic acid plays an important role in balancing plant immunity and growth. In this issue of Cell Host & Microbe, Liu et al. (2022) discovered that a long non-coding RNA, lncSABC1, promotes growth in uninfected plants and unleashes defenses when pathogens attack by transcriptionally regulating salicylic acid biosynthesis.
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Gut-bladder axis enters the stage: Implication for recurrent urinary tract infections Cell Host Microbe (IF 31.316) Pub Date : 2022-08-10 Arnold M. Salazar, Michael L. Neugent, Nicole J. De Nisco, Indira U. Mysorekar
The gut microbiome is a critical modulator of systemic physiology, including infectious disease susceptibility. Although this niche is a reservoir for uropathogenic Escherichia coli, knowledge of its role in urinary tract infections (UTIs) is limited. We discuss two recent studies, Thänert et al. (2022) and Worby et al. (2022), that interrogate the roles of the gut-bladder axis in UTIs.
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Holding back: HLA-associated inhibition of NK cells gives HIV a leg up Cell Host Microbe (IF 31.316) Pub Date : 2022-08-10 Stephanie Jost
In this issue of Cell Host & Microbe, Li et al. unveil an association between HLA-B∗46:01 and HIV disease progression in Asian populations. The distinct natural killer (NK) cell signature identified in individuals carrying HLA-B∗46:01 strongly suggests that NK cell inhibition plays a role in loss of HIV control.
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Adenosine sulfamates: Next generation of antimalarials Cell Host Microbe (IF 31.316) Pub Date : 2022-08-10 Sesh A. Sundararaman, Audrey R. Odom John
Tackling the ancient infectious foe of malaria, Xie et al. (2022) uncover a novel class of nucleoside analogs that selectively hijack and inhibit the tyrosine tRNA synthase of the parasite. With high potency, good oral bioavailability, and minimal host cell toxicity, these inhibitors show promise as next-generation antimalarials.
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Butyrate-producing Eubacterium rectale suppresses lymphomagenesis by alleviating the TNF-induced TLR4/MyD88/NF-κB axis Cell Host Microbe (IF 31.316) Pub Date : 2022-08-10 Haiyang Lu, Xiaoqiang Xu, Di Fu, Yubei Gu, Rong Fan, Hongmei Yi, Xiangyi He, Chaofu Wang, Binshen Ouyang, Ping Zhao, Li Wang, Pengpeng Xu, Shu Cheng, Zhifeng Wang, Duowu Zou, Lizhong Han, Weili Zhao
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Antibody escape and cryptic cross-domain stabilization in the SARS-CoV-2 Omicron spike protein Cell Host Microbe (IF 31.316) Pub Date : 2022-08-04 Kamyab Javanmardi, Thomas H. Segall-Shapiro, Chia-Wei Chou, Daniel R. Boutz, Randall J. Olsen, Xuping Xie, Hongjie Xia, Pei-Yong Shi, Charlie D. Johnson, Ankur Annapareddy, Scott Weaver, James M. Musser, Andrew D. Ellington, Ilya J. Finkelstein, Jimmy D. Gollihar
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A lncRNA fine-tunes salicylic acid biosynthesis to balance plant immunity and growth Cell Host Microbe (IF 31.316) Pub Date : 2022-07-30 Ningkun Liu, Yanzhuo Xu, Qi Li, Yuxin Cao, Dechang Yang, Shasha Liu, Xiaokang Wang, Yingjie Mi, Yang Liu, Chenxi Ding, Yan Liu, Yong Li, Yao-Wu Yuan, Ge Gao, Jinfeng Chen, Weiqiang Qian, Xiaoming Zhang
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Immunological memory to Common Cold Coronaviruses assessed longitudinally over a three-year period pre-COVID19 pandemic Cell Host Microbe (IF 31.316) Pub Date : 2022-07-20 Esther Dawen Yu, Tara M. Narowski, Eric Wang, Emily Garrigan, Jose Mateus, April Frazier, Daniela Weiskopf, Alba Grifoni, Lakshmanane Premkumar, Ricardo da Silva Antunes, Alessandro Sette
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Gut commensals expand vitamin A metabolic capacity of the mammalian host Cell Host Microbe (IF 31.316) Pub Date : 2022-07-20 Maryam Bonakdar, Lindsay C. Czuba, Geongoo Han, Guo Zhong, Hien Luong, Nina Isoherrannen, Shipra Vaishnava
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Determinants of Spike Infectivity, Processing and Neutralization in SARS-CoV-2 Omicron subvariants BA.1 and BA.2 Cell Host Microbe (IF 31.316) Pub Date : 2022-07-18 Chiara Pastorio, Fabian Zech, Sabrina Noettger, Christoph Jung, Timo Jacob, Theo Sanderson, Konstantin M.J. Sparrer, Frank Kirchhoff
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HLA-B∗46 associates with rapid HIV disease progression in Asian cohorts and prominent differences in NK cell phenotype Cell Host Microbe (IF 31.316) Pub Date : 2022-07-15 Shuying S. Li, Andrew Hickey, Shida Shangguan, Philip K. Ehrenberg, Aviva Geretz, Lauryn Butler, Gautam Kundu, Richard Apps, Matthew Creegan, Robert J. Clifford, Suteeraporn Pinyakorn, Leigh Anne Eller, Pikunchai Luechai, Peter B. Gilbert, Timothy H. Holtz, Anupong Chitwarakorn, Carlo Sacdalan, Eugène Kroon, Rasmi Thomas
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Antibiotic treatment ignites a fire that lasts Cell Host Microbe (IF 31.316) Pub Date : 2022-07-13 Iván C. Acosta, Francis Alonzo
Tissue damage and persistent inflammation are distinctive features of antibiotic-resistant chronic infections. In this issue of Cell Host & Microbe, Tang et al. demonstrate that anti-folate antibiotics trigger the synthesis of a bacterial second messenger, which induces an exuberant immune response and establishes a paradigm for chronic infection.
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Gut microbiota gestalt Cell Host Microbe (IF 31.316) Pub Date : 2022-07-13 Jonathan Melamed, Gabrielle LeBlanc, Michael G. Constantinides
The pathogenicity of disease-associated microbes varies widely between individuals. In this issue of Cell Host & Microbe, Rice et al. demonstrate that interactions between intestinal commensals reciprocally modulate the host immune response to each microbe, ameliorating the inflammation caused by one and dampening antibody responses to the other.
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Lactobacillus reuteri joins the liver autoimmune arena Cell Host Microbe (IF 31.316) Pub Date : 2022-07-13 Maria Serena Longhi
Type 1 CD8 T cells (Tc1s) have been implicated in liver injury in autoimmune hepatitis (AIH) through mechanisms that have so far been unclear. In this issue of Cell Host & Microbe, Pandey et al. show that the aryl hydrocarbon receptor ligand-producing pathobiont Lactobacillus reuteri induces Tc1-mediated AIH-like pathology in mice with Tet-methylcytosine-dioxygenase-2 deficiency.
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The dominoes fall after long-term antibiotic exposure Cell Host Microbe (IF 31.316) Pub Date : 2022-07-13 Bing Zhai, Robert T. Wheeler
Broad-spectrum antibiotics should prevent disease, right? In this issue of Cell Host & Microbe, Drummond et al. turn logic on its head and show they actually drive more deadly invasive fungal-bacterial systemic co-infection. Prophylactic antibiotics increase susceptibility to these infections by targeting the commensal microbes required for gut-derived IL-17-mediated immunity.
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A bacterial record collection Cell Host Microbe (IF 31.316) Pub Date : 2022-07-13 Carolina Tropini
Gut microbiota transcripts are notoriously hard to record accurately during perturbations because it is difficult to collect the signals near the source and at the time of variation. A recent study by Schmidt et al. in Science demonstrates a technology that overcomes these barriers.
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Advances and challenges in cataloging the human gut virome Cell Host Microbe (IF 31.316) Pub Date : 2022-07-13 Junhua Li, Fangming Yang, Minfeng Xiao, Aixin Li
The human gut virome, which is often referred to as the “dark matter” of the gut microbiome, remains understudied. A better understanding of the composition and variations of the gut virome across populations is critical for exploring its impact on diseases and health. A series of advances in the characterization of human gut virome have unveiled high genetic diversity and various functional potentials
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The logic of virus evolution Cell Host Microbe (IF 31.316) Pub Date : 2022-07-13 Eugene V. Koonin, Valerian V. Dolja, Mart Krupovic
Viruses are obligate intracellular parasites. Despite their dependence on host cells, viruses are evolutionarily autonomous, with their own genomes and evolutionary trajectories locked in arms races with the hosts. Here, we discuss a simple functional logic to explain virus macroevolution that appears to define the course of virus evolution. A small core of virus hallmark genes that are responsible
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SARS-CoV-2 Omicron sublineages exhibit distinct antibody escape patterns Cell Host Microbe (IF 31.316) Pub Date : 2022-07-07 Henning Gruell, Kanika Vanshylla, Michael Korenkov, Pinkus Tober-Lau, Matthias Zehner, Friederike Münn, Hanna Janicki, Max Augustin, Philipp Schommers, Leif Erik Sander, Florian Kurth, Christoph Kreer, Florian Klein
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Non-protective immune imprint underlies failure of Staphylococcus aureus IsdB vaccine Cell Host Microbe (IF 31.316) Pub Date : 2022-07-07 Chih-Ming Tsai, J.R. Caldera, Irshad A. Hajam, Austin W.T. Chiang, Chih-Hsiung Tsai, Haining Li, María Lázaro Díez, Cesia Gonzalez, Desmond Trieu, Gislâine A. Martins, David M. Underhill, Moshe Arditi, Nathan E. Lewis, George Y. Liu
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Emergence and widespread circulation of a recombinant SARS-CoV-2 lineage in North America Cell Host Microbe (IF 31.316) Pub Date : 2022-06-20 Bernardo Gutierrez, Hugo G. Castelán Sánchez, Darlan da Silva Candido, Ben Jackson, Shay Fleishon, Renaud Houzet, Christopher Ruis, Luis Delaye, Nuno R. Faria, Andrew Rambaut, Oliver G. Pybus, Marina Escalera-Zamudio
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A target expression threshold dictates invader defense and prevents autoimmunity by CRISPR-Cas13 Cell Host Microbe (IF 31.316) Pub Date : 2022-06-10 Elena Vialetto, Yanying Yu, Scott P. Collins, Katharina G. Wandera, Lars Barquist, Chase L. Beisel
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Fatty liver? Microbiome sphingolipids to the rescue Cell Host Microbe (IF 31.316) Pub Date : 2022-06-08 Eric M. Brown
In this issue of Cell Host & Microbe, Le et al. discover that addition of exogenous Bacteroides sphingolipids can reverse lipid accumulation in the liver in a mouse model of hepatic steatosis. An elegant labeling strategy also revealed a unique microbially produced sphingolipid that was able to transit to the liver.
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The kiss of death: Limosilactobacillus reuteri PKS drives intraspecies competition Cell Host Microbe (IF 31.316) Pub Date : 2022-06-08 Sandrine P. Claus
The gut microbial ecosystem is governed by complex microbe-microbe interactions, with most documented as interspecies relationships. In this issue of Cell Host & Microbe, Özçam et al. identified intraspecies competition among related strains of the gut symbiont Limosilactobacillus reuteri that are mediated via the antimicrobial activity of polyketide synthase (PKS).
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Won’t you be my neighbor? The importance of biogeography and nutrient niches in the gut Cell Host Microbe (IF 31.316) Pub Date : 2022-06-08 Arwa Abbas, Joseph P. Zackular
In the complex gastrointestinal tract landscape, competition for resources is fierce among microbes. One way to avoid conflict is migration to a different microhabitat. In this issue of Cell Host & Microbe, Liou et al. demonstrate how a commensal and pathogen differ in how and where they acquire nitrate.
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Stitching together a healthy gut microbiome with fiber Cell Host Microbe (IF 31.316) Pub Date : 2022-06-08 Thomas M. Schmidt
Inter-individual variability in the gut microbiome confounds efforts to understand host responses to dietary fiber. In this issue of Cell Host & Microbe, Lancaster et al. report individual and generalized host and microbiome responses in an interventional study of fiber supplements, motivating consideration of an alternative classification of fiber.
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Rethinking healthy eating in light of the gut microbiome Cell Host Microbe (IF 31.316) Pub Date : 2022-06-08 Anissa M. Armet, Edward C. Deehan, Aidan F. O’Sullivan, João F. Mota, Catherine J. Field, Carla M. Prado, Alice J. Lucey, Jens Walter
Given the worldwide epidemic of diet-related chronic diseases, evidence-based dietary recommendations are fundamentally important for health promotion. Despite the importance of the human gut microbiota for the physiological effects of diet and chronic disease etiology, national dietary guidelines around the world are just beginning to capitalize on scientific breakthroughs in the microbiome field
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Unwanted passengers: Microbes hitchiking in breast cancer metastases Cell Host Microbe (IF 31.316) Pub Date : 2022-06-08 Sheetal Parida, Julia L. Drewes
In a recent Cell paper, Fu et al. bridge descriptive cancer microbiome research with mechanistic and functional insight. With savvy use of antibiotics, the authors demonstrate divergent roles of the gut and intratumoral microbiome in breast tumor growth and metastasis, providing potentially actionable tools for better breast cancer management.
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Thanks, but no thanks: Cholera pathogen keeps incoming DNA at bay Cell Host Microbe (IF 31.316) Pub Date : 2022-06-08 Salvador Almagro-Moreno
Bacterial pathogens must maintain a delicate balance between acquiring novel genetic material and preserving their well-engrained cell physiology. In the recent study by Jaskólska et al., an astonishing example of this sophisticated phenomenon was found in Vibrio cholerae,with the pandemic strain encoding systems within two horizontally acquired pathogenicity islands that degrade incoming DNA.
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Tet2 deficiency drives liver microbiome dysbiosis triggering Tc1 cell autoimmune hepatitis Cell Host Microbe (IF 31.316) Pub Date : 2022-06-02 Surya P. Pandey, Mackenzie J. Bender, Alex C. McPherson, Catherine M. Phelps, Luzmariel Medina Sanchez, Mohit Rana, Lee Hedden, Kishan A. Sangani, Li Chen, Jake H. Shapira, Magdalena Siller, Chhavi Goel, Elena F. Verdú, Bana Jabri, Alexander Chang, Uma R. Chandran, Steven J. Mullett, Stacy G. Wendell, Marlies Meisel
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Gut bacterial isoamylamine promotes age-related cognitive dysfunction by promoting microglial cell death Cell Host Microbe (IF 31.316) Pub Date : 2022-06-01 Yun Teng, Jingyao Mu, Fangyi Xu, Xiangcheng Zhang, Mukesh K. Sriwastva, Qiaohong M. Liu, Xiaohong Li, Chao Lei, Kumaran Sundaram, Xin Hu, Lifeng Zhang, Juw Won Park, Jae Yeon Hwang, Eric C. Rouchka, Xiang Zhang, Jun Yan, Michael L. Merchant, Huang-Ge Zhang
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Interspecies commensal interactions have nonlinear impacts on host immunity Cell Host Microbe (IF 31.316) Pub Date : 2022-05-30 Tyler A. Rice, Agata A. Bielecka, Mytien T. Nguyen, Connor E. Rosen, Deguang Song, Nicole D. Sonnert, Yi Yang, Yiyun Cao, Varnica Khetrapal, Jason R. Catanzaro, Anjelica L. Martin, Saleh A. Rashed, Shana R. Leopold, Liming Hao, Xuezhu Yu, David van Dijk, Aaron M. Ring, Richard A. Flavell, Noah W. Palm
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Impact of a 7-day homogeneous diet on interpersonal variation in human gut microbiomes and metabolomes Cell Host Microbe (IF 31.316) Pub Date : 2022-05-27 Leah Guthrie, Sean Paul Spencer, Dalia Perelman, Will Van Treuren, Shuo Han, Feiqiao Brian Yu, Erica D. Sonnenburg, Michael A. Fischbach, Timothy W. Meyer, Justin L. Sonnenburg
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Host hepatic metabolism is modulated by gut microbiota-derived sphingolipids Cell Host Microbe (IF 31.316) Pub Date : 2022-05-26 Henry H. Le, Min-Ting Lee, Kevin R. Besler, Elizabeth L. Johnson
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A short prokaryotic Argonaute activates membrane effector to confer antiviral defense Cell Host Microbe (IF 31.316) Pub Date : 2022-05-19 Zhifeng Zeng, Yu Chen, Rafael Pinilla-Redondo, Shiraz A. Shah, Fen Zhao, Chen Wang, Zeyu Hu, Chang Wu, Changyi Zhang, Rachel J. Whitaker, Qunxin She, Wenyuan Han
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Host cells subdivide nutrient niches into discrete biogeographical microhabitats for gut microbes Cell Host Microbe (IF 31.316) Pub Date : 2022-05-13 Megan J. Liou, Brittany M. Miller, Yael Litvak, Henry Nguyen, Dean E. Natwick, Hannah P. Savage, Jordan A. Rixon, Scott P. Mahan, Hirotaka Hiyoshi, Andrew W.L. Rogers, Eric M. Velazquez, Brian P. Butler, Sean R. Collins, Stephen J. McSorley, Rasika M. Harshey, Mariana X. Byndloss, Scott I. Simon, Andreas J. Bäumler
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Long-term antibiotic exposure promotes mortality after systemic fungal infection by driving lymphocyte dysfunction and systemic escape of commensal bacteria Cell Host Microbe (IF 31.316) Pub Date : 2022-05-13 Rebecca A. Drummond, Jigar V. Desai, Emily E. Ricotta, Muthulekha Swamydas, Clay Deming, Sean Conlan, Mariam Quinones, Veronika Matei-Rascu, Lozan Sherif, David Lecky, Chyi-Chia R. Lee, Nathaniel M. Green, Nicholas Collins, Adrian M. Zelazny, D. Rebecca Prevots, David Bending, David Withers, Yasmine Belkaid, Michail S. Lionakis
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Preemies going pro: How probiotic treatment matures the microbiome of extreme premature infants Cell Host Microbe (IF 31.316) Pub Date : 2022-05-11 Dena Ennis, Nadav Moriel, Moran Yassour
Preterm birth can have long-term health consequences, and the gut microbiome is an important contributor to infant health. In this issue of Cell Host & Microbe, Samara et al. explore the effects of probiotics treatment on the infant gut microbiome of extremely premature infants.
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The mother of all synbiotics: Just a spoonful of sugar makes the bugs stick around Cell Host Microbe (IF 31.316) Pub Date : 2022-05-11 Tessa M. Andermann, Aadra P. Bhatt
Success of live biotherapeutics depends upon sustained and durable engraftment of beneficial microbes with robust functional output. In this issue of Cell Host & Microbe, Button et al. (2022) report that a human milk oligosaccharide-Bifidobacterium synbiotic delivers by supporting functional engraftment in healthy adults without antibiotic administration.
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RTS,S today and tomorrow’s science Cell Host Microbe (IF 31.316) Pub Date : 2022-05-11 Nginache Nampota Nkomba, Cristiana Cairo, Miriam K. Laufer
The first malaria vaccine has been recently approved for children living in malaria-endemic areas. While this is long-awaited and welcome news, the modest efficacy of the vaccine highlights several areas that require further attention. Here, we describe the likely impact of the vaccine and where clinical and basic discovery research will still be required.
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Can maternal-child microbial seeding interventions improve the health of infants delivered by Cesarean section? Cell Host Microbe (IF 31.316) Pub Date : 2022-05-11 Suchitra K. Hourigan, Maria Gloria Dominguez-Bello, Noel T. Mueller
Maternal-child microbial seeding interventions expose Cesarean-section (C-section)-delivered infants to the maternal microbiome they bypass during Cesarean delivery. It is theorized such interventions restore the microbiome and normalize immune development to reduce the occurrence of C-section-associated inflammatory conditions. Here we discuss the rationale, evidence, and controversies surrounding
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Gut microbiome and necrotizing enterocolitis: Understanding the connection to find a cure Cell Host Microbe (IF 31.316) Pub Date : 2022-05-11 Monowar Aziz, Jose M. Prince, Ping Wang
Necrotizing enterocolitis (NEC), a cause of death among premature babies, has defied therapeutics for decades. Bacterial analyses have expanded insights into NEC pathophysiology and roles of the gut microbiome. We discuss the contribution of the gut microbiome and potential therapeutics, notably lactadherin, that may promote gut homeostasis to alleviate NEC.
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Gut microbiome development and childhood undernutrition Cell Host Microbe (IF 31.316) Pub Date : 2022-05-11 Michael J. Barratt, Tahmeed Ahmed, Jeffrey I. Gordon
Forty-five percent of deaths among children under 5 years of age are associated with undernutrition. Globally, almost 200 million children exhibit the two major forms of undernutrition—wasting (low weight-for-height) or stunting (low height-for-age), with many affected by both. Undernutrition is not due to food insecurity alone. Growing evidence indicates that perturbed postnatal gut microbiome development
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The developing infant gut microbiome: A strain-level view Cell Host Microbe (IF 31.316) Pub Date : 2022-05-11 Hagay Enav, Fredrik Bäckhed, Ruth E. Ley
At birth, neonates provide a vast habitat awaiting microbial colonization. Microbiome assembly is a complex process involving microbial seeding and succession driven by ecological forces and subject to environmental conditions. These successional events not only significantly affect the ecology and function of the microbiome, but also impact host health. While the establishment of the infant microbiome
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The pediatric virome in health and disease Cell Host Microbe (IF 31.316) Pub Date : 2022-05-11 Guanxiang Liang, Hongyan Gao, Frederic D. Bushman
Associations between the global microbiome and diseases of children have been studied extensively; however, research on the viral component of the microbiome, the “virome,” is less advanced. The analysis of disease associations with the virome is often technically challenging, requiring a close examination of the “virome dark matter.” The gut is a particularly rich source of viral particles, and now
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Secretory IgA: Linking microbes, maternal health, and infant health through human milk Cell Host Microbe (IF 31.316) Pub Date : 2022-05-11 Katherine Donald, Charisse Petersen, Stuart E. Turvey, B. Brett Finlay, Meghan B. Azad
Secretory immunoglobulin A (SIgA) in human milk plays a central role in complex maternal-infant interactions that influence long-term health outcomes. Governed by genetics and maternal microbial exposure, human milk SIgA shapes both the microbiota and immune system of infants. Historically, SIgA-microbe interactions have been challenging to unravel due to their dynamic and personalized nature, particularly
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Maternal immune protection against infectious diseases Cell Host Microbe (IF 31.316) Pub Date : 2022-05-11 Stephanie N. Langel, Maria Blasi, Sallie R. Permar
The maternal immune system protects developing offspring against pathogens before birth via transplacental transfer and after birth through secreted milk. This transferred maternal immunity influences each generation’s susceptibility to infections and responsiveness to immunization. Thus, boosting immunity in the maternal-neonatal dyad is a potentially valuable public health strategy. Additionally
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The resistance within: Antibiotic disruption of the gut microbiome and resistome dynamics in infancy Cell Host Microbe (IF 31.316) Pub Date : 2022-05-11 Robert Thänert, Sanjam S. Sawhney, Drew J. Schwartz, Gautam Dantas
Intestinal host-microbiota interactions during the first year of life are critical for infant development. Early-life antibiotic exposures disrupt stereotypical gut microbiota maturation and adversely affect childhood health. Furthermore, antibiotics increase the abundance of resistant bacteria and enrich the resistome—the compendium of antibiotic resistance genes—within the gut microbiota. Here, we
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Early life host-microbe interactions in skin Cell Host Microbe (IF 31.316) Pub Date : 2022-05-11 Laura R. Dwyer, Tiffany C. Scharschmidt
Our skin is the interface through which we mediate lifelong interactions with our surrounding environment. Initial development of the skin’s epidermis, adnexal structures, and barrier function is necessary for normal cutaneous microbial colonization, immune development, and prevention of disease. Early life microbial exposures can have unique and long-lasting impacts on skin health. The identity of
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Supplementation with a probiotic mixture accelerates gut microbiome maturation and reduces intestinal inflammation in extremely preterm infants Cell Host Microbe (IF 31.316) Pub Date : 2022-05-11 Jumana Samara, Shirin Moossavi, Belal Alshaikh, Van A. Ortega, Veronika Kuchařová Pettersen, Tahsin Ferdous, Suzie L. Hoops, Amuchou Soraisham, Joseph Vayalumkal, Deonne Dersch-Mills, Jeffrey S. Gerber, Sagori Mukhopadhyay, Karen Puopolo, Thomas A. Tompkins, Dan Knights, Jens Walter, Harish Amin, Marie-Claire Arrieta
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Persisting uropathogenic Escherichia coli lineages show signatures of niche-specific within-host adaptation mediated by mobile genetic elements Cell Host Microbe (IF 31.316) Pub Date : 2022-05-10 Robert Thänert, JooHee Choi, Kimberly A. Reske, Tiffany Hink, Anna Thänert, Meghan A. Wallace, Bin Wang, Sondra Seiler, Candice Cass, Margaret H. Bost, Emily L. Struttmann, Zainab Hassan Iqbal, Steven R. Sax, Victoria J. Fraser, Arthur W. Baker, Katherine R. Foy, Brett Williams, Ben Xu, Gautam Dantas
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Antibody evasion of SARS-CoV-2 Omicron BA.1, BA.1.1, BA.2, and BA.3 sub-lineages Cell Host Microbe (IF 31.316) Pub Date : 2022-05-08 Jingwen Ai, Xun Wang, Xinyi He, Xiaoyu Zhao, Yi Zhang, Yuchao Jiang, Minghui Li, Yuchen Cui, Yanjia Chen, Rui Qiao, Lin Li, Lulu Yang, Yi Li, Zixin Hu, Wenhong Zhang, Pengfei Wang
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SARS-CoV-2 Omicron sublineages show comparable cell entry but differential neutralization by therapeutic antibodies Cell Host Microbe (IF 31.316) Pub Date : 2022-05-06 Prerna Arora, Lu Zhang, Nadine Krüger, Cheila Rocha, Anzhalika Sidarovich, Sebastian Schulz, Amy Kempf, Luise Graichen, Anna-Sophie Moldenhauer, Anne Cossmann, Alexandra Dopfer-Jablonka, Georg M.N. Behrens, Hans-Martin Jäck, Stefan Pöhlmann, Markus Hoffmann
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Dosing a synbiotic of human milk oligosaccharides and B. infantis leads to reversible engraftment in healthy adult microbiomes without antibiotics Cell Host Microbe (IF 31.316) Pub Date : 2022-05-02 Julie E. Button, Chloe A. Autran, Abigail L. Reens, Casey M. Cosetta, Steven Smriga, Megan Ericson, Jessica V. Pierce, David N. Cook, Martin L. Lee, Adam K. Sun, Amin M. Alousi, Andrew Y. Koh, David J. Rechtman, Robert R. Jenq, Gregory J. McKenzie
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Global, distinctive, and personal changes in molecular and microbial profiles by specific fibers in humans Cell Host Microbe (IF 31.316) Pub Date : 2022-04-27 Samuel M. Lancaster, Brittany Lee-McMullen, Charles Wilbur Abbott, Jeniffer V. Quijada, Daniel Hornburg, Heyjun Park, Dalia Perelman, Dylan J. Peterson, Michael Tang, Aaron Robinson, Sara Ahadi, Kévin Contrepois, Chia-Jui Hung, Melanie Ashland, Tracey McLaughlin, Anna Boonyanit, Aaron Horning, Justin L. Sonnenburg, Michael P. Snyder
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Neutralization of SARS-CoV-2 Omicron sub-lineages BA.1, BA.1.1, and BA.2 Cell Host Microbe (IF 31.316) Pub Date : 2022-04-25 John P. Evans, Cong Zeng, Panke Qu, Julia Faraone, Yi-Min Zheng, Claire Carlin, Joseph S. Bednash, Tongqing Zhou, Gerard Lozanski, Rama Mallampalli, Linda J. Saif, Eugene M. Oltz, Peter J. Mohler, Kai Xu, Richard J. Gumina, Shan-Lu Liu
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A secondary metabolite drives intraspecies antagonism in a gut symbiont that is inhibited by cell-wall acetylation Cell Host Microbe (IF 31.316) Pub Date : 2022-04-19 Mustafa Özçam, Jee-Hwan Oh, Restituto Tocmo, Deepa Acharya, Shenwei Zhang, Theresa J. Astmann, Mark Heggen, Silvette Ruiz-Ramírez, Fuyong Li, Christopher C. Cheng, Eugenio Vivas, Federico E. Rey, Jan Claesen, Tim S. Bugni, Jens Walter, Jan-Peter van Pijkeren