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Cystathionine γ-lyase promotes estrogen-stimulated uterine artery blood flow via glutathione homeostasis Redox Biol. (IF 9.986) Pub Date : 2020-12-08 Rachael Bok; Damian D. Guerra; Ramón A. Lorca; Sara A. Wennersten; Peter S. Harris; Abhishek K. Rauniyar; Sally P. Stabler; Kenneth N. MacLean; James R. Roede; Laura D. Brown; K. Joseph Hurt
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Oxidative Eustress: On Constant Alert for Redox Homeostasis Redox Biol. (IF 9.986) Pub Date : 2021-01-20 Helmut Sies
In the open metabolic system, redox-related signaling requires continuous monitoring and fine-tuning of the steady-state redox set point. The ongoing oxidative metabolism is a persistent challenge, denoted as oxidative eustress, which operates within a physiological range that has been called the ‘Homeodynamic Space’, the ‘Goldilocks Zone’ or the ‘Golden Mean’. Spatiotemporal control of redox signaling
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Role of oxidative stress in the dysfunction of the placental endothelial Nitric Oxide synthase in preeclampsia Redox Biol. (IF 9.986) Pub Date : 2021-01-19 Paul GUERBY; Oriane TASTA; Audrey SWIADER; Frédéric PONT; Emmanuel BUJOLD; Olivier PARANT; Christophe VAYSSIERE; Robert SALVAYRE; Anne NEGRE-SALVAYRE
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Long non-coding RNA Meg3 deficiency impairs glucose homeostasis and insulin signaling by inducing cellular senescence of hepatic endothelium in obesity Redox Biol. (IF 9.986) Pub Date : 2021-01-19 Xiao Cheng; Mohamed Sham Shihabudeen Haider Ali; Matthew Moran; Martonio Ponte Viana; Sarah L. Schlichte; Matthew C. Zimmerman; Oleh Khalimonchuk; Mark W. Feinberg; Xinghui Sun
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The program of renal fibrogenesis is controlled by microRNAs regulating oxidative metabolism Redox Biol. (IF 9.986) Pub Date : 2020-12-28 Verónica Miguel; Ricardo Ramos; Laura García-Bermejo; Diego Rodríguez-Puyol; Santiago Lamas
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Heat shock protein 22 modulates NRF1/TFAM-dependent mitochondrial biogenesis and DRP1-sparked mitochondrial apoptosis through AMPK-PGC1α signaling pathway to alleviate the early brain injury of subarachnoid hemorrhage in rats Redox Biol. (IF 9.986) Pub Date : 2021-01-06 Haiyan Fan; Rui Ding; Wenchao Liu; Xin zhang; Ran Li; Boyang Wei; Shixing Su; Fa Jin; Chengcong Wei; Xuying He; Xifeng Li; Chuanzhi Duan
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Galanin promotes autophagy and alleviates apoptosis in the hypertrophied heart through FoxO1 pathway Redox Biol. (IF 9.986) Pub Date : 2021-01-16 Ilenia Martinelli; Andrei Timotin; Paula Moreno-Corchado; Dimitri Marsal; Solomiia Kramar; Halina Loy; Carine Joffre; Frederic Boal; Helene Tronchere; Oksana Kunduzova
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Apolipoprotein E deficiency induces a progressive increase in tissue iron contents with age in mice Redox Biol. (IF 9.986) Pub Date : 2021-01-16 Juan Ma; Christopher Qian; Yong Bao; Meng-Yue Liu; Hui-Min Ma; Meng-Qi Shen; Wei Li; Jiao-Jiao Wang; Yu-Xin Bao; Yong Liu; Ya Ke; Zhong-Ming Qian
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Utilization of redox modulating small molecules that selectively act as pro-oxidants in cancer cells to open a therapeutic window for improving cancer therapy Redox Biol. (IF 9.986) Pub Date : 2021-01-16 M.S. Petronek; J.M. Stolwijk; S.D. Murray; E.J. Steinbach; Y. Zakharia; G.R. Buettner; D.R. Spitz; B.G. Allen
There is a rapidly growing body of literature supporting the notion that differential oxidative metabolism in cancer versus normal cells represents a metabolic frailty that can be exploited to open a therapeutic window into cancer therapy. These cancer cell-specific metabolic frailties may be amenable to manipulation with non-toxic small molecule redox active compounds traditionally thought to be antioxidants
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Reactive oxygen species induce Cys106-mediated anti-parallel HMGB1 dimerization that protects against DNA damage Redox Biol. (IF 9.986) Pub Date : 2021-01-07 Man Sup Kwak; Woo Joong Rhee; Yong Joon Lee; Hee Sue Kim; Young Hun Kim; Min Kyung Kwon; Jeon-Soo Shin
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Melatonin protects against environmental stress-induced fetal growth restriction via suppressing ROS-mediated GCN2/ATF4/BNIP3-dependent mitophagy in placental trophoblasts Redox Biol. (IF 9.986) Pub Date : 2021-01-06 Hua-Long Zhu; Xue-Ting Shi; Xiao-Feng Xu; Guo-Xiang Zhou; Yong-Wei Xiong; Song-Jia Yi; Wei-Bo Liu; Li-Min Dai; Xue-Lin Cao; De-Xiang Xu; Hua Wang
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OGG1 co-inhibition antagonizes the tumor-inhibitory effects of targeting MTH1 Redox Biol. (IF 9.986) Pub Date : 2021-01-02 Ling Zhang; Laura Misiara; Govindi J. Samaranayake; Nisha Sharma; Dao M. Nguyen; Yu-Ki Tahara; Eric T. Kool; Priyamvada Rai
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Localized increases in CEPT1 and ATGL elevate plasmalogen phosphatidylcholines in HDLs contributing to atheroprotective lipid profiles in hyperglycemic GCK-MODY Redox Biol. (IF 9.986) Pub Date : 2021-01-06 Xiaojing Wang; Sin Man Lam; Mingjun Cao; Tong Wang; Zhixin Wang; Miao Yu; Bowen Li; Huabing Zhang; Fan Ping; Guangyao Song; Kai Feng; Qian Zhang; Jianping Xu; Liyuan Zhou; Mingqun Deng; Xiao Zhai; Xinhua Xiao; Guanghou Shui
Glucokinase-maturity onset diabetes of the young (GCK-MODY) represents a rare genetic disorder due to mutation in the glucokinase (GCK) gene. The low incidence of vascular complications in GCK-MODY makes it a natural paradigm for interrogating molecular mechanisms promoting vascular health under prolonged hyperglycemia. Clinical rate of misdiagnosis has remained high, and a reliable serum lipid biomarker
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Re-definition and supporting evidence toward Fanconi Anemia as a mitochondrial disease: Prospects for new design in clinical management Redox Biol. (IF 9.986) Pub Date : 2021-01-07 Giovanni Pagano; Luca Tiano; Federico V. Pallardó; Alex Lyakhovich; Sudit S. Mukhopadhyay; Paolo Di Bartolomeo; Adriana Zatterale; Marco Trifuoggi
Fanconi anemia (FA) has been investigated since early studies based on two definitions, namely defective DNA repair and proinflammatory condition. The former definition has built up the grounds for FA diagnosis as excess sensitivity of patients’ cells to xenobiotics as diepoxybutane and mitomycin C, resulting in typical chromosomal abnormalities. Another line of studies has related FA phenotype to
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Chalcone suppresses tumor growth through NOX4-IRE1α sulfonation-RIDD-miR-23b axis Redox Biol. (IF 9.986) Pub Date : 2021-01-06 Hyun-Kyoung Kim; Hwa-Young Lee; Thoufiqul Alam Riaz; Kashi Raj Bhattarai; Manoj Chaudhary; Jin Hee Ahn; Jieun Jeong; Hyung-Ryung Kim; Han-Jung Chae
Chalcone is a polyphenolic compound found abundantly in natural plant components. They have been acclaimed as potential antitumor compounds in multiple tumor cells. However, not much attention has been paid to elucidate its antitumor mechanism of action. Here, chalcone was demonstrated to trigger endoplasmic reticulum (ER) stress-induced apoptosis through sulfonation of IRE1α by ER-localized NADPH
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The protective effects of fibroblast growth factor 10 against hepatic ischemia-reperfusion injury in mice Redox Biol. (IF 9.986) Pub Date : 2021-01-07 Santie Li; Zhongxin Zhu; Mei Xue; Xuebo Pan; Gaozan Tong; Xinchu Yi; Junfu Fan; Yuankuan Li; Wanqian Li; Yetong Dong; Enzhao Shen; Wenjie Gong; Xuejiao Wang; Ying Yu; Yoo Jae Maeng; Xiaokun Li; Kwang Youl Lee; Litai Jin; Weitao Cong
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Ex vivo fecal fermentation of human ileal fluid collected after raspberry consumption modifies (poly)phenolics and modulates genoprotective effects in colonic epithelial cells Redox Biol. (IF 9.986) Pub Date : 2021-01-12 Sara Dobani; Cheryl Latimer; Gordon J. McDougall; J. William Allwood; Gema Pereira-Caro; José Manuel Moreno-Rojas; Nigel G. Ternan; L. Kirsty Pourshahidi; Roger Lawther; Kieran M. Tuohy; Daniele Del Rio; Gloria O’Connor; Ian Rowland; Tahani Mazyad Almutairi; Alan Crozier; Chris I.R. Gill
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Hypochlorite-induced aggregation of fibrinogen underlies a novel antioxidant role in blood plasma Redox Biol. (IF 9.986) Pub Date : 2020-12-30 Noralyn Mañucat-Tan; Rafaa Zeineddine Abdallah; Harsimran Kaur; Daniel Saviane; Mark R. Wilson; Amy R. Wyatt
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The toxic side of one-carbon metabolism and epigenetics Redox Biol. (IF 9.986) Pub Date : 2020-12-28 Agustín E. Morellato; Carla Umansky; Lucas B. Pontel
One-carbon metabolism is a central metabolic hub that provides one-carbon units for essential biosynthetic reactions and for writing epigenetics marks. The leading role in this hub is performed by the one-carbon carrier tetrahydrofolate (THF), which accepts formaldehyde usually from serine generating one-carbon THF intermediates in a set of reactions known as the folate or one-carbon cycle. THF derivatives
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A versatile EPR toolbox for the simultaneous measurement of oxygen consumption and superoxide production Redox Biol. (IF 9.986) Pub Date : 2020-12-28 Donatienne d’Hose; Pierre Danhier; Heidi Northschield; Pauline Isenborghs; Bénédicte F. Jordan; Bernard Gallez
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RhoA GTPase phosphorylated at tyrosine 42 by src kinase binds to β-catenin and contributes transcriptional regulation of vimentin upon Wnt3A Redox Biol. (IF 9.986) Pub Date : 2020-12-25 Jae-Gyu Kim; Shohel Mahmud; Jung Ki Min; Yoon-Beom Lee; Hyunbin Kim; Dong-Chul Kang; Hwee-Seon Park; Jihye Seong; Jae-Bong Park
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HIV TAT-mediated microglial senescence: Role of SIRT3-dependent mitochondrial oxidative stress Redox Biol. (IF 9.986) Pub Date : 2020-12-23 Annadurai Thangaraj; Ernest T. Chivero; Ashutosh Tripathi; Seema Singh; Fang Niu; Ming-Lei Guo; Prakash Pillai; Palsamy Periyasamy; Shilpa Buch
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Cell-penetrating, antioxidant SELENOT mimetic protects dopaminergic neurons and ameliorates motor dysfunction in Parkinson’s disease animal models Redox Biol. (IF 9.986) Pub Date : 2020-12-28 Ifat Alsharif; Loubna Boukhzar; Benjamin Lefranc; David Godefroy; Juliette Aury-Landas; Jean-Luc do Rego; Jean-Claude do Rego; Frédéric Naudet; Arnaud Arabo; Abdeslam Chagraoui; David Maltête; Abdelhamid Benazzouz; Catherine Baugé; Jérôme Leprince; Abdel G. Elkahloun; Lee E. Eiden; Youssef Anouar
Parkinson’s disease (PD) is a neurodegenerative disorder characterized by motor dysfunction for which there is an unmet need for better treatment options. Although oxidative stress is a common feature of neurodegenerative diseases, notably PD, there is currently no efficient therapeutic strategy able to tackle this multi-target pathophysiological process. Based on our previous observations of the potent
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Trem2 mediated Syk-dependent ROS amplification is essential for osteoclastogenesis in periodontitis microenvironment Redox Biol. (IF 9.986) Pub Date : 2020-12-28 Yuteng Weng; Haicheng Wang; Lin Li; Yanhuizhi Feng; Shuyu Xu; Chaoyuan Li; Zuolin Wang
Periodontitis is the sixth most prevalent diseases around the globe, which is closely related to many systemic diseases and affects general health. As the leading cause of tooth loss, periodontitis is characterized by irreversible alveolar bone loss and activated osteoclastogenic process, which might be closely related to the activated intracellular reactive oxygen species (ROS) in osteoclasts. Here
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NRF2 function in osteocytes is required for bone homeostasis and drives osteocytic gene expression Redox Biol. (IF 9.986) Pub Date : 2020-12-24 Cristina Sánchez-de-Diego; Leonardo Pedrazza; Carolina Pimenta-Lopes; Arturo Martinez-Martinez; Norma Dahdah; José Antonio Valer; Pablo Garcia-Roves; Jose Luis Rosa; Francesc Ventura
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Oxysterols present in Alzheimer's disease brain induce synaptotoxicity by activating astrocytes: A major role for lipocalin-2 Redox Biol. (IF 9.986) Pub Date : 2020-12-17 Erica Staurenghi; Valentina Cerrato; Paola Gamba; Gabriella Testa; Serena Giannelli; Valerio Leoni; Claudio Caccia; Annalisa Buffo; Wendy Noble; Beatriz Gomez Perez-Nievas; Gabriella Leonarduzzi
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aFGF alleviates diabetic endothelial dysfunction by decreasing oxidative stress via Wnt/β-catenin-mediated upregulation of HXK2 Redox Biol. (IF 9.986) Pub Date : 2020-12-19 Jia Sun; Xiaozhong Huang; Chao Niu; Xuejiao Wang; Wanqian Li; Mengxue Liu; Ying Wang; Shuai Huang; Xixi Chen; Xiaokun Li; Yang Wang; Litai Jin; Jian Xiao; Weitao Cong
Vascular complications of diabetes are a serious challenge in clinical practice, and effective treatments are an unmet clinical need. Acidic fibroblast growth factor (aFGF) has potent anti-oxidative properties and therefore has become a research focus for the treatment of diabetic vascular complications. However, the specific mechanisms by which aFGF regulates these processes remain unclear. The purpose
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Context-dependent responses of Drosophila intestinal stem cells to intracellular reactive oxygen species Redox Biol. (IF 9.986) Pub Date : 2020-12-17 Fei Chen; Run Su; Shiwei Ni; Yan Liu; Jiexiang Huang; Gege Li; Qun Wang; Xi Zhang; Yufeng Yang
Reactive oxygen species (ROS) contribute to cellular redox environment and serve as signaling molecules. Excessive ROS can lead to oxidative stress that are involved in a broad spectrum of physiological and pathological conditions. Stem cells have unique ROS regulation while cancer cells frequently show a constitutive oxidative stress that is associated with the invasive phenotype. Antioxidants have
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Targeting Mitochondrial Ion Channels for Cancer Therapy Redox Biol. (IF 9.986) Pub Date : 2020-12-24 Ildiko Szabo; Mario Zoratti; Lucia Biasutto
Pharmacological targeting of mitochondrial ion channels is emerging as a promising approach to eliminate cancer cells; as most of these channels are differentially expressed and/or regulated in cancer cells in comparison to healthy ones, this strategy may selectively eliminate the former. Perturbation of ion fluxes across the outer and inner membranes is linked to alterations of redox state, membrane
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Genomic GLO1 deletion modulates TXNIP expression, glucose metabolism, and redox homeostasis while accelerating human A375 malignant melanoma tumor growth Redox Biol. (IF 9.986) Pub Date : 2020-12-17 Jana Jandova; Georg T. Wondrak
Glyoxalase 1 (encoded by GLO1) is a glutathione-dependent enzyme detoxifying the glycolytic byproduct methylglyoxal (MG), an oncometabolite involved in metabolic reprogramming. Recently, we have demonstrated that GLO1 is overexpressed in human malignant melanoma cells and patient tumors and substantiated a novel role of GLO1 as a molecular determinant of invasion and metastasis in melanoma. Here, employing
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NADPH oxidase 4 (Nox4) deletion accelerates liver regeneration in mice Redox Biol. (IF 9.986) Pub Date : 2020-12-23 M. Herranz-Itúrbide; J. López-Luque; E. Gonzalez-Sanchez; D. Caballero-Díaz; E. Crosas-Molist; B. Martín-Mur; M. Gut; A. Esteve-Codina; V. Jaquet; J.X. Jiang; N.J. Török; I. Fabregat
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An inherent dysfunction in soluble guanylyl cyclase is present in the airway of severe asthmatics and is associated with aberrant redox enzyme expression and compromised NO-cGMP signaling Redox Biol. (IF 9.986) Pub Date : 2020-12-13 Arnab Ghosh; Cynthia J. Koziol-White; William F. Jester; Serpil C. Erzurum; Kewal Asosingh; Reynold A. Panettieri; Dennis J. Stuehr
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Renovascular effects of inorganic nitrate following ischemia-reperfusion of the kidney Redox Biol. (IF 9.986) Pub Date : 2020-12-17 Gensheng Zhang; Huirong Han; Zhengbing Zhuge; Fang Dong; Shan Jiang; Wenwen Wang; Drielle D. Guimarães; Tomas A. Schiffer; En Yin Lai; Lucas Rannier Ribeiro Antonino Carvalho; Ricardo Barbosa Lucena; Valdir A. Braga; Eddie Weitzberg; Jon O. Lundberg; Mattias Carlstrom
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A redox-mediated conformational change in NQO1 controls binding to microtubules and α-tubulin acetylation Redox Biol. (IF 9.986) Pub Date : 2020-12-18 David Siegel; Stephanie Bersie; Peter Harris; Andrea Di Francesco; Michael Armstrong; Nichole Reisdorph; Michel Bernier; Rafael de Cabo; Kristofer Fritz; David Ross
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Antimicrobial effects of nitric oxide in murine models of Klebsiella pneumonia Redox Biol. (IF 9.986) Pub Date : 2020-12-11 Steffen B. Wiegand; Lisa Traeger; Huan K. Nguyen; Kaitlyn R. Rouillard; Anna Fischbach; Francesco Zadek; Fumito Ichinose; Mark H. Schoenfisch; Ryan W. Carroll; Donald B. Bloch; Warren M. Zapol
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A novel nitroalkene vitamin E analogue inhibits the NLRP3 inflammasome and protects against inflammation and glucose intolerance triggered by obesity Redox Biol. (IF 9.986) Pub Date : 2020-12-15 Rosina Dapueto; Jorge Rodriguez-Duarte; Germán Galliussi; Andrés Kamaid; Mariana Bresque; Carlos Batthyány; Gloria V. López; Carlos Escande
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Sustained IKKβ Phosphorylation and NF-κB Activation by Superoxide-induced Peroxynitrite-mediated Nitrotyrosine Modification of B56γ3 and PP2A Inactivation Redox Biol. (IF 9.986) Pub Date : 2020-12-18 Yi Hui Yee; Stephen Jun Fei Chong; Li Ren Kong; Boon Cher Goh; Shazib Pervaiz
Apart from its physiological role in inflammation and immunity, the nuclear factor-kappa B (NF-κB) protein complex has been implicated in tumorigenesis and its progression. Here, we provide evidence that a pro-oxidant milieu is an upstream effector of oncogenic NF-κB signaling. Through pharmacological or genetic inhibition of SOD1, we show that elevated intracellular superoxide (O2•-) mediates sustained
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Miro1-mediated mitochondrial positioning supports subcellular redox status Redox Biol. (IF 9.986) Pub Date : 2020-11-29 Haya Alshaabi; Nathaniel Shannon; Randi Gravelle; Stephanie Milczarek; Terri Messier; Brian Cunniff
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Glycocalyx sialic acids regulate Nrf2-mediated signaling by fluid shear stress in human endothelial cells Redox Biol. (IF 9.986) Pub Date : 2020-11-28 Paraskevi-Maria Psefteli; Phoebe Kitscha; Gema Vizcay; Roland Fleck; Sarah J. Chapple; Giovanni E. Mann; Mark Fowler; Richard C. Siow
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Oxidation of protein disulfide bonds by singlet oxygen gives rise to glutathionylated proteins Redox Biol. (IF 9.986) Pub Date : 2020-12-01 Shuwen Jiang; Luke Carroll; Lars M. Rasmussen; Michael J. Davies
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Liver kinase B1 inhibits smooth muscle calcification via high mobility group box 1 Redox Biol. (IF 9.986) Pub Date : 2020-12-06 Tianran Zhang; Hongxuan Li; Changhan Ouyang; Guangqing Cao; Jiangang Gao; Jiliang Wu; Jianmin Yang; Nengwang Yu; Qing Min; Cheng Zhang; Wencheng Zhang
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Hexameric procyanidins inhibit colorectal cancer cell growth through both redox and non-redox regulation of the epidermal growth factor signaling pathway Redox Biol. (IF 9.986) Pub Date : 2020-12-10 Elena Daveri; Ana M. Adamo; Eugenia Alfine; Wei Zhu; Patricia I. Oteiza
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Modulating glutathione thiol status alters pancreatic β-cell morphogenesis in the developing zebrafish (Danio rerio) embryo Redox Biol. (IF 9.986) Pub Date : 2020-11-06 Archit Rastogi; Emily G. Severance; Haydee M. Jacobs; Sarah M. Conlin; Sadia T. Islam; Alicia R. Timme-Laragy
Emerging evidence suggests that redox-active chemicals perturb pancreatic islet development. To better understand potential mechanisms for this, we used zebrafish (Danio rerio) embryos to investigate roles of glutathione (GSH; predominant cellular redox buffer) and the transcription factor Nrf2a (Nfe2l2a; zebrafish Nrf2 co-ortholog) in islet morphogenesis. We delineated critical windows of susceptibility
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Hydrogen sulfide releasing molecule MZe786 inhibits soluble Flt-1 and prevents preeclampsia in a refined RUPP mouse model Redox Biol. (IF 9.986) Pub Date : 2020-11-28 Jaimy Saif; Shakil Ahmad; Homira Rezai; Karina Litvinova; Anna Sparatore; Faisal A. Alzahrani; Keqing Wang; Asif Ahmed
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Response to commentary Redox Biol. (IF 9.986) Pub Date : 2020-12-13 Bo Xiong
In our article [1], we supplemented melatonin to aged female mice to assess its impact on the oocyte quality especially the prevention of oocyte aneuploidy that frequently occurs with the maternal age. We found that in vivo supplementation of melatonin recovered its levels in the serum and follicular fluid that were decreased in aged female mice, and thus protected aged oocytes from meiotic defects
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Selenium and impaired physical function in US and Spanish older adults Redox Biol. (IF 9.986) Pub Date : 2020-11-28 E. García-Esquinas; M. Carrasco-Rios; R. Ortolá; M. Sotos Prieto; B. Pérez-Gómez; E. Gutiérrez-González; J.R. Banegas; R. Queipo; P. Olmedo; F. Gil; M. Tellez-Plaza; A. Navas-Acien; R. Pastor-Barriuso; F. Rodríguez-Artalejo
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Structural and functional insights into nitrosoglutathione reductase from Chlamydomonas reinhardtii Redox Biol. (IF 9.986) Pub Date : 2020-11-24 Andrea Tagliani; Jacopo Rossi; Christophe H. Marchand; Marcello De Mia; Daniele Tedesco; Libero Gurrieri; Maria Meloni; Giuseppe Falini; Paolo Trost; Stéphane D. Lemaire; Simona Fermani; Mirko Zaffagnini
Protein S-nitrosylation plays a fundamental role in cell signaling and nitrosoglutathione (GSNO) is considered as the main nitrosylating signaling molecule. Enzymatic systems controlling GSNO homeostasis are thus crucial to indirectly control the formation of protein S-nitrosothiols. GSNO reductase (GSNOR) is the key enzyme controlling GSNO levels by catalyzing its degradation in the presence of NADH
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Sestrin2 maintains OXPHOS integrity to modulate cardiac substrate metabolism during ischemia and reperfusion Redox Biol. (IF 9.986) Pub Date : 2020-12-01 Di Ren; Zhibin He; Julia Fedorova; Jingwen Zhang; Elizabeth Wood; Xiang Zhang; David E. Kang; Ji Li
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Decreased bioavailability of hydrogen sulfide links vascular endothelium and atrial remodeling in atrial fibrillation Redox Biol. (IF 9.986) Pub Date : 2020-12-03 Megan Watts; Gopi K. Kolluru; Parinita Dherange; Sibile Pardue; Man Si; Xinggui Shen; Krystle Trosclair; John Glawe; Zaki Al-Yafeai; Mazen Iqbal; Brenna H. Pearson; Kathryn A. Hamilton; A. Wayne Orr; Edward Glasscock; Christopher G. Kevil; Paari Dominic
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Methionine sulfoxide reductase B3 deficiency inhibits the development of diet-induced insulin resistance in mice Redox Biol. (IF 9.986) Pub Date : 2020-12-01 Hye-Na Cha; Chang-Hoon Woo; Hwa-Young Kim; So-Young Park
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Increased Sirt1 secreted from visceral white adipose tissue is associated with improved glucose tolerance in obese Nrf2-deficient mice Redox Biol. (IF 9.986) Pub Date : 2020-11-24 Laura Braud; Maria Pini; Donald F. Stec; Sylvie Manin; Geneviève Derumeaux; David E. Stec; Roberta Foresti; Roberto Motterlini
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In situ labeling of non-accommodating interneurons based on metabolic rates Redox Biol. (IF 9.986) Pub Date : 2020-11-28 G.C. Gotti; M. Kikhia; V. Wuntke; L.A. Hasam-Henderson; B. Wu; J.R.P. Geiger; R. Kovacs
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Calpains play an essential role in mechanical ventilation-induced diaphragmatic weakness and mitochondrial dysfunction Redox Biol. (IF 9.986) Pub Date : 2020-11-25 Hayden W. Hyatt; Mustafa Ozdemir; Toshinori Yoshihara; Branden L. Nguyen; Rafael Deminice; Scott K. Powers
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Polysulfide-mediated sulfhydration of SIRT1 prevents diabetic nephropathy by suppressing phosphorylation and acetylation of p65 NF-κB and STAT3 Redox Biol. (IF 9.986) Pub Date : 2020-11-25 Hai-Jian Sun; Si-Ping Xiong; Xu Cao; Lei Cao; Meng-Yuan Zhu; Zhi-Yuan Wu; Jin-Song Bian
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Altered glucose metabolism and cell function in keloid fibroblasts under hypoxia Redox Biol. (IF 9.986) Pub Date : 2020-11-28 Qifei Wang; Pu Wang; Zelian Qin; Xin Yang; Bailin Pan; Fangfei Nie; Hongsen Bi
Keloids exhibit metabolic reprogramming including enhanced glycolysis and attenuated oxidative phosphorylation. Hypoxia induces a series of protective responses in mammalian cells. However, the metabolic phenotype of keloid fibroblasts under hypoxic conditions remains to be elucidated. The present study aimed to investigate glycolytic activity, mitochondrial function and morphology, and the HIF1α and
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Idebenone: When an antioxidant is not an antioxidant Redox Biol. (IF 9.986) Pub Date : 2020-11-25 Nuri Gueven; Pranathi Ravishankar; Rajaraman Eri; Emma Rybalka
Idebenone is a well described drug that was initially developed against dementia. The current literature widely portrays this molecule as a potent antioxidant and CoQ10 analogue. While numerous papers seem to support this view, a closer look indicates that the pharmacokinetics of idebenone do not support these claims. A major discrepancy between achievable tissue levels, especially in target tissues
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Glutathione reductase deficiency alters lung development and hyperoxic responses in neonatal mice Redox Biol. (IF 9.986) Pub Date : 2020-11-13 Mary E. Robbins; Hye-Youn Cho; Jason M. Hansen; Joseph R. Luchsinger; Morgan L. Locy; Markus Velten; Steven R. Kleeberger; Lynette K. Rogers; Trent E. Tipple
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Magnetic resonance imaging (MRI) of pharmacological ascorbate-induced iron redox state as a biomarker in subjects undergoing radio-chemotherapy Redox Biol. (IF 9.986) Pub Date : 2020-11-19 Cameron M. Cushing; Michael S. Petronek; Kellie L. Bodeker; Sandy Vollstedt; Heather A. Brown; Emyleigh Opat; Nancy J. Hollenbeck; Thomas Shanks; Daniel J. Berg; Brian J. Smith; Mark C. Smith; Varun Monga; Muhammad Furqan; Matthew A. Howard; Jeremy D. Greenlee; Kranti A. Mapuskar; Joel St-Aubin; Ryan T. Flynn; Vincent A. Magnotta
Pharmacological ascorbate (P-AscH-) combined with standard of care (SOC) radiation and temozolomide is being evaluated in a phase 2 clinical trial (NCT02344355) in the treatment of glioblastoma (GBM). Previously published data demonstrated that paramagnetic iron (Fe3+) catalyzes ascorbate's oxidation to form diamagnetic iron (Fe2+). Because paramagnetic Fe3+ may influence relaxation times observed
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Cyclobutane pyrimidine dimers from UVB exposure induce a hypermetabolic state in keratinocytes via mitochondrial oxidative stress Redox Biol. (IF 9.986) Pub Date : 2020-11-25 Csaba Hegedűs; Tamás Juhász; Eszter Fidrus; Eszter Anna Janka; Gábor Juhász; Gábor Boros; György Paragh; Karen Uray; Gabriella Emri; Éva Remenyik; Péter Bai
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Gas plasma-spurred wound healing is accompanied by regulation of focal adhesion, matrix remodeling, and tissue oxygenation Redox Biol. (IF 9.986) Pub Date : 2020-11-25 Anke Schmidt; Grit Liebelt; Felix Nießner; Thomas von Woedtke; Sander Bekeschus