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SLC7A11-ROS/αKG-AMPK axis regulates liver inflammation through mitophagy and impairs liver fibrosis and NASH progression Redox Biol. (IF 11.4) Pub Date : 2024-04-16 Tingting Lv, Xiude Fan, Chang He, Suwei Zhu, Xiaofeng Xiong, Wei Yan, Mei Liu, Hongwei Xu, Ruihua Shi, Qin He
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Differentiation of intestinal stem cells toward goblet cells under systemic iron overload stress are associated with inhibition of Notch signaling pathway and ferroptosis Redox Biol. (IF 11.4) Pub Date : 2024-04-15 Jing Zhao, Wan Ma, Sisi Wang, Kang Zhang, Qingqing Xiong, Yunqin Li, Hong Yu, Huahua Du
Iron overload can lead to oxidative stress and intestinal damage and happens frequently during blood transfusions and iron supplementation. However, how iron overload influences intestinal mucosa remains unknown. Here, the aim of current study was to investigate the effects of iron overload on the proliferation and differentiation of intestinal stem cells (ISCs). An iron overload mouse model was established
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Atox1 protects hippocampal neurons after traumatic brain injury via DJ-1 mediated anti-oxidative stress and mitophagy Redox Biol. (IF 11.4) Pub Date : 2024-04-12 Pengzhan Zhao, Wenqian Shi, Yangfan Ye, Ke Xu, Jingming Hu, Honglu Chao, ZeQiang Tao, Lei Xu, Wei Gu, Liuchao Zhang, Tian Wang, Xinyue Wang, Jing Ji
Regulation of the oxidative stress response is crucial for the management and prognosis of traumatic brain injury (TBI). The copper chaperone Antioxidant 1 (Atox1) plays a crucial role in regulating intracellular copper ion balance and impacting the antioxidant capacity of mitochondria, as well as the oxidative stress state of cells. However, it remains unknown whether Atox1 is involved in modulating
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PM2.5-induced iron homeostasis imbalance triggers cardiac hypertrophy through ferroptosis in a selective autophagy crosstalk manner Redox Biol. (IF 11.4) Pub Date : 2024-04-12 Tianyu Li, Mengqi Sun, Qinglin Sun, Xiaoke Ren, Qing Xu, Zhiwei Sun, Junchao Duan
Exposure to PM is correlated with cardiac remodeling, of which cardiac hypertrophy is one of the main clinical manifestations. Ferroptosis plays an important role in cardiac hypertrophy. However, the potential mechanism of PM-induced cardiac hypertrophy through ferroptosis remains unclear. This study aimed to explore the molecular mechanism of cardiac hypertrophy caused by PM and the intervention role
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Inhibition of METTL3 ameliorates doxorubicin-induced cardiotoxicity through suppression of TFRC-mediated ferroptosis Redox Biol. (IF 11.4) Pub Date : 2024-04-12 Lin Wu, Yuxin Du, Litao Wang, Yingmei Zhang, Jun Ren
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The emerging importance of the α-keto acid dehydrogenase complexes in serving as intracellular and intercellular signaling platforms for the regulation of metabolism Redox Biol. (IF 11.4) Pub Date : 2024-04-10 Ryan J. Mailloux
The α-keto acid dehydrogenase complex (KDHc) class of mitochondrial enzymes is composed of four members: pyruvate dehydrogenase (PDHc), α-ketoglutarate dehydrogenase (KGDHc), branched-chain keto acid dehydrogenase (BCKDHc), and 2-oxoadipate dehydrogenase (OADHc). These enzyme complexes occupy critical metabolic intersections that connect monosaccharide, amino acid, and fatty acid metabolism to Krebs
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Angiotension II directly bind P2X7 receptor to induce myocardial ferroptosis and remodeling by activating human antigen R Redox Biol. (IF 11.4) Pub Date : 2024-04-09 Xin Zhong, Kangwei Wang, Yonghua Wang, Luya Wang, Sudan Wang, Weijian Huang, Zhuyin Jia, Shan-Shan Dai, Zhouqing Huang
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An orally active carbon monoxide-releasing molecule enhances beneficial gut microbial species to combat obesity in mice Redox Biol. (IF 11.4) Pub Date : 2024-04-09 Djamal Eddine Benrahla, Shruti Mohan, Matija Trickovic, Florence Anne Castelli, Ghida Alloul, Arielle Sobngwi, Rosa Abdiche, Silas Kieser, Vanessa Demontant, Elisabeth Trawinski, Céline Chollet, Christophe Rodriguez, Hiroaki Kitagishi, François Fenaille, Mirko Trajkovski, Roberto Motterlini, Roberta Foresti
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Therapeutic nuclear magnetic resonance and intermittent hypoxia trigger time dependent on/off effects in circadian clocks and confirm a central role of superoxide in cellular magnetic field effects Redox Biol. (IF 11.4) Pub Date : 2024-04-05 Viktoria Thoeni, Elitsa Y. Dimova, Thomas Kietzmann, Robert J. Usselman, Margit Egg
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Selenite selectively kills lung fibroblasts to treat bleomycin-induced pulmonary fibrosis Redox Biol. (IF 11.4) Pub Date : 2024-04-05 Jiun-Han Lin, Chen-Chi Liu, Chao-Yu Liu, Tien-Wei Hsu, Yi-Chen Yeh, Chorng-Kuang How, Han-Shui Hsu, Shih-Chieh Hung
Interstitial lung disease (ILD) treatment is a critical unmet need. Selenium is an essential trace element for human life and an antioxidant that activates glutathione, but the gap between its necessity and its toxicity is small and requires special attention. Whether selenium can be used in the treatment of ILD remains unclear. We investigated the prophylactic and therapeutic effects of selenite,
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S-nitrosocysteamine-functionalised porous graphene oxide nanosheets as nitric oxide delivery vehicles for cardiovascular applications Redox Biol. (IF 11.4) Pub Date : 2024-04-04 Tanveer A. Tabish, Mian Zahid Hussain, Sevasti Zervou, William K. Myers, Weiming Tu, Jiabao Xu, Irina Beer, Wei E. Huang, Rona Chandrawati, Mark J. Crabtree, Paul G. Winyard, Craig A. Lygate
Nitric oxide (NO) is a key signalling molecule released by vascular endothelial cells that is essential for vascular health. Low NO bioactivity is associated with cardiovascular diseases, such as hypertension, atherosclerosis, and heart failure and NO donors are a mainstay of drug treatment. However, many NO donors are associated with the development of tolerance and adverse effects, so new formulations
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Gut bacteria exacerbates TNBS-induced colitis and kidney injury through oxidative stress Redox Biol. (IF 11.4) Pub Date : 2024-04-04 Yang Sui, Rui Jiang, Manabu Niimi, Xin Wang, Yijun Xu, Yingyu Zhang, Zhuheng Shi, Mika Suda, Zhimin Mao, Jianglin Fan, Jian Yao
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Salmonella Typhimurium employs spermidine to exert protection against ROS-mediated cytotoxicity and rewires host polyamine metabolism to ameliorate its survival in macrophages Redox Biol. (IF 11.4) Pub Date : 2024-04-03 Abhilash Vijay Nair, Anmol Singh, R.S. Rajmani, Dipshikha Chakravortty
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S-Adenosyl-l-methionine restores brain mitochondrial membrane fluidity and GSH content improving Niemann-Pick type C disease Redox Biol. (IF 11.4) Pub Date : 2024-04-03 Leire Goicoechea, Sandra Torres, Laura Fàbrega, Mónica Barrios, Susana Núñez, Josefina Casas, Gemma Fabrias, Carmen García-Ruiz, José C. Fernández-Checa
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ALOX15B controls macrophage cholesterol homeostasis via lipid peroxidation, ERK1/2 and SREBP2 Redox Biol. (IF 11.4) Pub Date : 2024-04-03 Yvonne Benatzy, Megan A. Palmer, Dieter Lütjohann, Rei-Ichi Ohno, Nadja Kampschulte, Nils Helge Schebb, Dominik C. Fuhrmann, Ryan G. Snodgrass, Bernhard Brüne
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Specificity and dynamics of H2O2 detoxification by the cytosolic redox regulatory network as revealed by in vitro reconstitution Redox Biol. (IF 11.4) Pub Date : 2024-04-03 Lara Vogelsang, Jürgen Eirich, Iris Finkemeier, Karl-Josef Dietz
The thiol redox state is a decisive functional characteristic of proteins in cell biology. Plasmatic cell compartments maintain a thiol-based redox regulatory network linked to the glutathione/glutathione disulfide couple (GSH/GSSG) and the NAD(P)H system. The basic network constituents are known and cell imaging with gene-encoded probes have revealed insight into the dynamics of the [GSH]/[GSSG] redox
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Single-embryo transcriptomic atlas of oxygen response reveals the critical role of HIF-1α in prompting embryonic zygotic genome activation Redox Biol. (IF 11.4) Pub Date : 2024-04-02 Fusheng Yao, Meiqiang Chu, Guangyin Xi, Jiage Dai, Zhaochen Wang, Jia Hao, Qianying Yang, Wenjing Wang, Yawen Tang, Jingyu Zhang, Yuan Yue, Yue Wang, Yefen Xu, Wei Zhao, Lizhu Ma, Juan Liu, Zhenni Zhang, Jianhui Tian, Lei An
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Platelet bioenergetic profiling uncovers a metabolic pattern of high dependency on mitochondrial fatty acid oxidation in type 2 diabetic patients who developed in-stent restenosis Redox Biol. (IF 11.4) Pub Date : 2024-04-02 Xue-Bin Wang, Ning-Hua Cui, Zi-Qi Fang, Mi-Jie Gao, Dan Cai
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The positive feedback loop of the NAT10/Mybbp1a/p53 axis promotes cardiomyocyte ferroptosis to exacerbate cardiac I/R injury Redox Biol. (IF 11.4) Pub Date : 2024-04-02 Zhezhe Qu, Xiaochen Pang, Zhongting Mei, Ying Li, Yaozhi Zhang, Chuanhao Huang, Kuiwu Liu, Shuting Yu, Changhao Wang, Zhiyong Sun, Yingqi Liu, Xin Li, Yingqiong Jia, Yuechao Dong, Meixi Lu, Tiantian Ju, Fan Wu, Min Huang, Na Li, Shunkang Dou, Jianhao Jiang, Xianhui Dong, Yi Zhang, Wanhong Li, Baofeng Yang, Weijie Du
Ferroptosis is a nonapoptotic form of regulated cell death that has been reported to play a central role in cardiac ischemia‒reperfusion (I/R) injury. N-acetyltransferase 10 (NAT10) contributes to cardiomyocyte apoptosis by functioning as an RNA ac4c acetyltransferase, but its role in cardiomyocyte ferroptosis during I/R injury has not been determined. This study aimed to elucidate the role of NAT10
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Linking triphenylphosphonium cation to a bicyclic hydroquinone improves their antiplatelet effect via the regulation of mitochondrial function Redox Biol. (IF 11.4) Pub Date : 2024-04-01 Diego Méndez, Francisca Tellería, Matías Monroy-Cárdenas, Héctor Montecino-Garrido, Santiago Mansilla, Laura Castro, Andrés Trostchansky, Felipe Muñoz-Córdova, Volker Zickermann, Jonathan Schiller, Sergio Alfaro, Julio Caballero, Ramiro Araya-Maturana, Eduardo Fuentes
Platelets are the critical target for preventing and treating pathological thrombus formation. However, despite current antiplatelet therapy, cardiovascular mortality remains high, and cardiovascular events continue in prescribed patients. In this study, first results were obtained with -carbonyl hydroquinones as antiplatelet agents; we found that linking triphenylphosphonium cation to a bicyclic carbonyl
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Biomarkers of NRF2 signalling: Current status and future challenges Redox Biol. (IF 11.4) Pub Date : 2024-03-30 Christina Morgenstern, Isabel Lastres-Becker, Birsen Can Demirdöğen, Vera Marisa Costa, Andreas Daiber, Roberta Foresti, Roberto Motterlini, Sibel Kalyoncu, Burak I. Arioz, Sermin Genc, Monika Jakubowska, Ioannis P. Trougakos, Aleksandra Piechota-Polanczyk, Michel Mickael, Marlene Santos, Thomas W. Kensler, Antonio Cuadrado, Ian M. Copple
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Fragment-based drug discovery and biological evaluation of novel cannabinol-based inhibitors of oxytosis/ferroptosis for neurological disorders Redox Biol. (IF 11.4) Pub Date : 2024-03-29 Zhibin Liang, Alec Candib, David Soriano-Castell, Wolfgang Fischer, Kim Finley, Pamela Maher
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Meningioma achieves malignancy and erastin-induced ferroptosis resistance through FOXM1-AURKA-NRF2 axis Redox Biol. (IF 11.4) Pub Date : 2024-03-28 Yangfan Ye, Lei Xu, Liuchao Zhang, Pengzhan Zhao, Wanzhi Cai, Guoqiang Fu, Tian Wang, Zeqiang Tao, Wenqian Shi, Wei Gu, Jingming Hu, Guangyao Yuan, Yutian Wei, Ke Xu, Zhongyuan Bao, Honglu Chao, Ning Liu, Lin Zhao, Yiming Tu, Jing Ji
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Αnti-prion effects of anthocyanins Redox Biol. (IF 11.4) Pub Date : 2024-03-28 Nikoletta Christoudia, Nikolaos Bekas, Eirini Kanata, Athanasia Chatziefsthathiou, Spyros Pettas, Korina Karagianni, Susana Margarida Da Silva Correia, Matthias Schmitz, Inga Zerr, Ioannis Tsamesidis, Konstantinos Xanthopoulos, Dimitra Dafou, Theodoros Sklaviadis
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MAPK15 controls cellular responses to oxidative stress by regulating NRF2 activity and expression of its downstream target genes Redox Biol. (IF 11.4) Pub Date : 2024-03-28 Lorenzo Franci, Giulia Vallini, Franca Maria Bertolino, Vittoria Cicaloni, Giovanni Inzalaco, Mattia Cicogni, Laura Tinti, Laura Calabrese, Virginia Barone, Laura Salvini, Pietro Rubegni, Federico Galvagni, Mario Chiariello
Oxidation processes in mitochondria and different environmental insults contribute to unwarranted accumulation of reactive oxygen species (ROS). These, in turn, rapidly damage intracellular lipids, proteins, and DNA, ultimately causing aging and several human diseases. Cells have developed different and very effective systems to control ROS levels. Among these, removal of excessive amounts is guaranteed
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Functional diversity of YbbN/CnoX proteins: Insights from a comparative analysis of three thioredoxin-like oxidoreductases from Pseudomonas aeruginosa, Xylella fastidiosa and Escherichia coli Redox Biol. (IF 11.4) Pub Date : 2024-03-28 Diogo de Abreu Meireles, César Henrique Yokomizo, Francisnei Pedrosa Silva, Thiago Motta Venâncio, Maximilia Frazão de Souza Degenhardt, Cristiano Luis Pinto de Oliveira, Luis Eduardo Soares Netto
YbbN/CnoX are proteins that display a Thioredoxin (Trx) domain linked to a tetratricopeptide domain. YbbN from (YbbN) displays a co-chaperone (holdase) activity that is induced by HOCl. Here, we compared YbbN with YbbN proteins from (YbbN) and from (YbbN). YbbN presents a redox active Cys residue at Trx domain (Cys63), 24 residues away from SQHC motif (SQHC[N]C) that can form mixed disulfides with
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Melanoma-associated melanocortin 1 receptor variants confer redox signaling-dependent protection against oxidative DNA damage Redox Biol. (IF 11.4) Pub Date : 2024-03-26 María Castejón-Griñán, Sonia Cerdido, José Sánchez-Beltrán, Ana Lambertos, Marta Abrisqueta, Cecilia Herraiz, Celia Jiménez-Cervantes, José Carlos García-Borrón
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NCF4 regulates antigen presentation of cysteine peptides by intracellular oxidative response and restricts activation of autoreactive and arthritogenic T cells Redox Biol. (IF 11.4) Pub Date : 2024-03-26 Jing Xu, Chang He, Yongsong Cai, Xipeng Wang, Jidong Yan, Jing Zhang, Fujun Zhang, Vilma Urbonaviciute, Yuanyuan Cheng, Shemin Lu, Rikard Holmdahl
Autoimmune diseases, such as rheumatoid arthritis (RA) and systemic lupus erythematous, are regulated by polymorphisms in genes contributing to the NOX2 complex. Mutations in both and affect development of arthritis in experimental models of RA, but the different regulatory pathways mediated by NOX2-derived reactive oxygen species (ROS) have not yet been clarified.
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In pursuit of feedback activation: New insights into redox-responsive hydropersulfide prodrug combating oxidative stress Redox Biol. (IF 11.4) Pub Date : 2024-03-21 Bi-Xin Xu, Tian-Yu Hu, Jin-Biao Du, Tao Xie, Ya-Wen Xu, Xin Jin, Si-Tao Xu, Hao-Wen Jin, Guangji Wang, Jiankun Wang, Le Zhen
Redox-responsive hydropersulfide prodrugs are designed to enable a more controllable and efficient hydropersulfide (RSSH) supply and to thoroughly explore their biological and therapeutic applications in oxidative damage. To obtain novel activation patterns triggered by redox signaling, we focused on NAD(P)H: quinone acceptor oxidoreductase 1 (NQO1), a canonical antioxidant enzyme, and designed NQO1-activated
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Semaglutide attenuates doxorubicin-induced cardiotoxicity by ameliorating BNIP3-Mediated mitochondrial dysfunction Redox Biol. (IF 11.4) Pub Date : 2024-03-19 Xiaoping Li, Wenbin Luo, Yang Tang, Jiangjiao Wu, Junkai Zhang, Shengnan Chen, Lu Zhou, Yu Tao, Yuanjuan Tang, Fengxian Wang, Yu Huang, Pedro A. Jose, Li Guo, Chunyu Zeng
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The redox-sensitive GSK3β is a key regulator of glomerular podocyte injury in type 2 diabetic kidney disease Redox Biol. (IF 11.4) Pub Date : 2024-03-16 Mengxuan Chen, Yudong Fang, Yan Ge, Shuhao Qiu, Lance Dworkin, Rujun Gong
Emerging evidence suggests that GSK3β, a redox-sensitive transducer downstream of insulin signaling, acts as a convergent point for myriad pathways implicated in kidney injury, repair, and regeneration. However, its role in diabetic kidney disease remains controversial. In cultured glomerular podocytes, exposure to a milieu of type 2 diabetes elicited prominent signs of podocyte injury and degeneration
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Comments on “was hydrogen peroxide present before the arrival of oxygenic photosynthesis? The important role of iron(II) in the archean ocean” Redox Biol. (IF 11.4) Pub Date : 2024-03-16 Xiao Wu, Jianxi Zhu, Hongping He, Kurt O. Konhauser, Yiliang Li
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WITHDRAWN: SAH is a major metabolic sensor mediating worsening metabolic crosstalk in metabolic syndrome Redox Biol. (IF 11.4) Pub Date : 2024-03-15 Ramon Cueto, Wen Shen, Lu Liu, Xianwei Wang, Sheng Wu, Sadia Mohsin, Ling Yang, Mohsin Khan, Wenhui Hu, Nathaniel Snyder, Qinghua Wu, Yong Ji, Xiao-Feng Yang, Hong Wang
This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause.
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ER-tethered RNA-binding protein controls NADPH oxidase translation for hydrogen peroxide homeostasis Redox Biol. (IF 11.4) Pub Date : 2024-03-15 Xintong Pei, Zhe Wang, Wenting He, Shunqin Li, Xiaowei Chen, Zhen Fan, Yongguang Lan, Lin Yuan, Pingyong Xu
Hydrogen peroxide (HO) functions as a signaling molecule in diverse cellular processes. While cells have evolved the capability to detect and manage changes in HO levels, the mechanisms regulating key HO-producing enzymes to maintain optimal levels, especially in pancreatic beta cells with notably weak antioxidative defense, remain unclear. We found that the protein EI24 responds to changes in HO concentration
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Visualizing mitochondrial heme flow through GAPDH in living cells and its regulation by NO Redox Biol. (IF 11.4) Pub Date : 2024-03-14 Pranjal Biswas, Joseph Palazzo, Simon Schlanger, Dhanya Thamaraparambil Jayaram, Sidra Islam, Richard C. Page, Dennis J. Stuehr
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Widespread S-persulfidation in activated macrophages as a protective mechanism against oxidative-inflammatory stress Redox Biol. (IF 11.4) Pub Date : 2024-03-13 Talal Salti, Ilana Braunstein, Yael Haimovich, Tamar Ziv, Moran Benhar
Acute inflammatory responses often involve the production of reactive oxygen and nitrogen species by innate immune cells, particularly macrophages. How activated macrophages protect themselves in the face of oxidative-inflammatory stress remains a long-standing question. Recent evidence implicates reactive sulfur species (RSS) in inflammatory responses; however, how endogenous RSS affect macrophage
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Endogenous sulfur dioxide deficiency as a driver of cardiomyocyte senescence through abolishing sulphenylation of STAT3 at cysteine 259 Redox Biol. (IF 11.4) Pub Date : 2024-03-13 Shangyue Zhang, Bingquan Qiu, Boyang Lv, Guosheng Yang, Yinghong Tao, Yongyan Hu, Kun Li, Xiaoqi Yu, Chaoshu Tang, Junbao Du, Hongfang Jin, Yaqian Huang
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Redox regulation of macrophages Redox Biol. (IF 11.4) Pub Date : 2024-03-12 Nhien Tran, Evanna L. Mills
Redox signaling, a mode of signal transduction that involves the transfer of electrons from a nucleophilic to electrophilic molecule, has emerged as an essential regulator of inflammatory macrophages. Redox reactions are driven by reactive oxygen/nitrogen species (ROS and RNS) and redox-sensitive metabolites such as fumarate and itaconate, which can post-translationally modify specific cysteine residues
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MASLD is related to impaired alcohol dehydrogenase (ADH) activity and elevated blood ethanol levels: Role of TNFα and JNK Redox Biol. (IF 11.4) Pub Date : 2024-03-12 Katharina Burger, Finn Jung, Katharina Staufer, Ruth Ladurner, Michael Trauner, Anja Baumann, Annette Brandt, Ina Bergheim
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Hybrid molecules synergistically mitigate ferroptosis and amyloid-associated toxicities in Alzheimer's disease Redox Biol. (IF 11.4) Pub Date : 2024-03-11 Dikshaa Padhi, Prayasee Baruah, Madhu Ramesh, Hariharan Moorthy, Thimmaiah Govindaraju
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Itaconic acid regulation of TFEB-mediated autophagy flux alleviates hyperoxia-induced bronchopulmonary dysplasia Redox Biol. (IF 11.4) Pub Date : 2024-03-11 Chengbo Liu, Changchang Fu, Yazhou Sun, You You, Tengfei Wang, Yongjun Zhang, Hongping Xia, Xingyun Wang
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The cytosolic hyperoxidation-sensitive and -robust Leishmania peroxiredoxins cPRX1 and cPRX2 are both dispensable for parasite infectivity Redox Biol. (IF 11.4) Pub Date : 2024-03-10 Helena Castro, Maria Inês Rocha, Margarida Duarte, Jordi Vilurbina, Ana Georgina Gomes-Alves, Teresa Leao, Filipa Dias, Bruce Morgan, Marcel Deponte, Ana Maria Tomás
Typical two-cysteine peroxiredoxins (2-Cys-PRXs) are HO-metabolizing enzymes whose activity relies on two cysteine residues. Protists of the family invariably express one cytosolic 2-Cys-PRX (cPRX1). However, the sub-family features an additional isoform (cPRX2), almost identical to cPRX1, except for the lack of an elongated C-terminus with a Tyr-Phe (YF) motif. Previously, cytosolic PRXs were considered
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Was H2O2 generated before oxygenic photosynthesis? Redox Biol. (IF 11.4) Pub Date : 2024-03-09 Willem H. Koppenol, Helmut Sies
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ATF3-CBS signaling axis coordinates ferroptosis and tumorigenesis in colorectal cancer Redox Biol. (IF 11.4) Pub Date : 2024-03-08 Junjia Liu, Xinyi Lu, Siyu Zeng, Rong Fu, Xindong Wang, Lingtao Luo, Ting Huang, Xusheng Deng, Hualei Zheng, Shaoqian Ma, Dan Ning, Lili Zong, Shu-Hai Lin, Yongyou Zhang
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IL-13 facilitates ferroptotic death in asthmatic epithelial cells via SOCS1-mediated ubiquitinated degradation of SLC7A11 Redox Biol. (IF 11.4) Pub Date : 2024-03-08 Manli Miao, Min Pan, Xu Chen, Jiapan Shen, Ling Zhang, Xiaoxia Feng, Mengting Chen, Guofeng Cui, Huaiyuan Zong, Wen Zhang, Shuang Chang, Fangzhou Xu, Zixi Wang, Dapeng Li, Weiwei Liu, Zhao Ding, Shengquan Zhang, Biao Chen, Xiaojun Zha, Xiaoyun Fan
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Inhibition of glycogen synthase kinase-3 enhances NRF2 protein stability, nuclear localisation and target gene transcription in pancreatic beta cells Redox Biol. (IF 11.4) Pub Date : 2024-03-07 Chinmai Patibandla, Lidy van Aalten, Albena T. Dinkova-Kostova, Tadashi Honda, Antonio Cuadrado, Raquel Fernández-Ginés, Alison D. McNeilly, John D. Hayes, James Cantley, Calum Sutherland
Accumulation of reactive oxygen species (i.e., oxidative stress) is a leading cause of beta cell dysfunction and apoptosis in diabetes. NRF2 (NF-E2 p45-related factor-2) regulates the adaptation to oxidative stress, and its activity is negatively regulated by the redox-sensitive CUL3 (cullin-3) ubiquitin ligase substrate adaptor KEAP1 (Kelch-like ECH-associated protein-1). Additionally, NRF2 is repressed
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GSTP alleviates acute lung injury by S-glutathionylation of KEAP1 and subsequent activation of NRF2 pathway Redox Biol. (IF 11.4) Pub Date : 2024-03-06 Xiaolin Sun, Chaorui Guo, Chunyan Huang, Ning Lv, Huili Chen, Haoyan Huang, Yulin Zhao, Shanliang Sun, Di Zhao, Jingwei Tian, Xijing Chen, Yongjie Zhang
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ERRγ-inducible FGF23 promotes alcoholic liver injury through enhancing CYP2E1 mediated hepatic oxidative stress Redox Biol. (IF 11.4) Pub Date : 2024-03-05 Yoon Seok Jung, Kamalakannan Radhakrishnan, Seddik Hammad, Sebastian Müller, Johannes Müller, Jung-Ran Noh, Jina kim, In-Kyu Lee, Sung Jin Cho, Don-Kyu Kim, Yong-Hoon Kim, Chul-Ho Lee, Steven Dooley, Hueng-Sik Choi
Fibroblast growth factor 23 (FGF23) is a member of endocrine FGF family, along with FGF15/19 and FGF21. Recent reports showed that under pathological conditions, liver produces FGF23, although the role of hepatic FGF23 remains nebulous. Here, we investigated the role of hepatic FGF23 in alcoholic liver disease (ALD) and delineated the underlying molecular mechanism. FGF23 expression was compared in
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Role of Selenoprotein W in participating in the progression of non-alcoholic fatty liver disease Redox Biol. (IF 11.4) Pub Date : 2024-03-05 Zhiruo Miao, Wei Wang, Zhiying Miao, Qiyuan Cao, Shiwen Xu
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Development of dietary small molecules as multi-targeting treatment strategies for Alzheimer's disease Redox Biol. (IF 11.4) Pub Date : 2024-03-04 Rengasamy Balakrishnan, Khoshnur Jannat, Dong-Kug Choi
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Nuclear translocation of metabolic enzyme PKM2 participates in high glucose-promoted HCC metastasis by strengthening immunosuppressive environment Redox Biol. (IF 11.4) Pub Date : 2024-03-04 Jiali Qian, Chuxin Huang, Mimi Wang, Ying Liu, Yingying Zhao, Miao Li, Xi Zhang, Xiangyu Gao, Yawen Zhang, Yi Wang, Jinya Huang, Jiajun Li, Qiwen Zhou, Rui Liu, Xuanchun Wang, Jiefeng Cui, Yehong Yang
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Enteric coronavirus PDCoV evokes a non-Warburg effect by hijacking pyruvic acid as a metabolic hub Redox Biol. (IF 11.4) Pub Date : 2024-03-04 Guanning Su, Jiao Liu, Chenrui Duan, Puxian Fang, Liurong Fang, Yanrong Zhou, Shaobo Xiao
The Warburg effect, also referred as aerobic glycolysis, is a common metabolic program during viral infection. Through targeted metabolomics combined with biochemical experiments and various cell models, we investigated the central carbon metabolism (CCM) profiles of cells infected with porcine deltacoronavirus (PDCoV), an emerging enteropathogenic coronavirus with zoonotic potential. We found that
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Human papillomavirus-16 E6 activates the pentose phosphate pathway to promote cervical cancer cell proliferation by inhibiting G6PD lactylation Redox Biol. (IF 11.4) Pub Date : 2024-03-01 Qingfei Meng, Yanghe Zhang, Huihui Sun, Xiangzhe Yang, Shiming Hao, Bin Liu, Honglan Zhou, Yishu Wang, Zhi-Xiang Xu
High-risk human papillomaviruses (HPVs) are the causative agents of cervical cancer. Here, we report that HPV16 E6E7 promotes cervical cancer cell proliferation by activating the pentose phosphate pathway (PPP). We found that HPV16 E6 activates the PPP primarily by increasing glucose-6-phosphate dehydrogenase (G6PD) enzyme activity. Mechanistically, HPV16 E6 promoted G6PD dimer formation by inhibiting
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Redox homeostasis in cardiac fibrosis: Focus on metal ion metabolism Redox Biol. (IF 11.4) Pub Date : 2024-03-01 Zhen-Yu Liu, Zhi-Yan Liu, Li-Chan Lin, Kai Song, Bin Tu, Ye Zhang, Jing-Jing Yang, Jian-Yuan Zhao, Hui Tao
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Control of the signaling role of PtdIns(4)P at the plasma membrane through H2O2-dependent inactivation of synaptojanin 2 during endocytosis Redox Biol. (IF 11.4) Pub Date : 2024-02-29 Su In Jo, Suree Kim, Jung Mi Lim, Sue Goo Rhee, Bo-Gyeong Jeong, Sun-Shin Cha, Jae-Byum Chang, Dongmin Kang
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Covalent organic framework based cytoprotective therapy after ischemic stroke Redox Biol. (IF 11.4) Pub Date : 2024-02-28 Yuqin Peng, Qingfan Ren, Huanrong Ma, Chuman Lin, Mingjia Yu, Yongchuan Li, Jiancong Chen, Haihao Xu, Peng Zhao, Suyue Pan, Jia Tao, Kaibin Huang
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Inhibition of MST1 ameliorates neuronal apoptosis via GSK3β/β-TrCP/NRF2 pathway in spinal cord injury accompanied by diabetes Redox Biol. (IF 11.4) Pub Date : 2024-02-28 Weijun Huang, Depeng Wu, Chaoyang Cai, Hui Yao, Zhenming Tian, Yang Yang, Mao Pang, Limin Rong, Bin Liu
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Corrigendum to “LRP1 activation attenuates white matter injury by modulating microglial polarization through Shc1/PI3K/Akt pathway after subarachnoid hemorrhage in rats” [Redox Biol. 21 (2019) 101121] Redox Biol. (IF 11.4) Pub Date : 2024-02-26 Jianhua Peng, Jinwei Pang, Lei Huang, Budbazar Enkhjargal, Tongyu Zhang, Jun Mo, Pei Wu, Weilin Xu, Yuchun Zuo, Jun Peng, Gang Zuo, Ligang Chen, Jiping Tang, John H. Zhang, Yong Jiang
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Corrigendum to “Ripk3 induces mitochondrial apoptosis via inhibition of FUNDC1 mitophagy in cardiac IR injury” [Redox Biol. 13 (2017) 495-507] Redox Biol. (IF 11.4) Pub Date : 2024-02-24 Hao Zhou, Pingjun Zhu, Jun Guo, Nan Hu, Shuyi Wang, Dandan Li, Shunying Hu, Jun Ren, Feng Cao, Yundai Chen
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Low-molecular-weight thiol transferases in redox regulation and antioxidant defence Redox Biol. (IF 11.4) Pub Date : 2024-02-24 Maria-Armineh Tossounian, Yuhan Zhao, Bess Yi Kun Yu, Samuel A. Markey, Oksana Malanchuk, Yuejia Zhu, Amanda Cain, Ivan Gout
Low-molecular-weight (LMW) thiols are produced in all living cells in different forms and concentrations. Glutathione (GSH), coenzyme A (CoA), bacillithiol (BSH), mycothiol (MSH), ergothioneine (ET) and trypanothione T(SH) are the main LMW thiols in eukaryotes and prokaryotes. LMW thiols serve as electron donors for thiol-dependent enzymes in redox-mediated metabolic and signaling processes, protect