-
The coupling of mitoproteolysis and oxidative phosphorylation enables tracking of an active mitochondrial state through MitoTimerfluorescence Redox Biol. (IF 10.787) Pub Date : 2022-08-18 Yinyin Xie, Yannan Zhang, Aina Sun, Yamei Peng, Weikang Hou, Cong Xiang, Guoxin Zhang, Beibei Lai, Xiaoshuang Hou, Fangfang Zheng, Fan Wang, Geng Liu
The regulation of mitochondria function and health is a central node in tissue maintenance, ageing as well as the pathogenesis of various diseases. However, the maintenance of an active mitochondrial functional state and its quality control mechanisms remain incompletely understood. By studying mice with a mitochondria-targeted reporter that shifts its fluorescence from “green” to “red” with time (MitoTimer)
-
Diagnostic values of circulating tetrahydrobiopterin levels as a novel biomarker in patients with thoracic and abdominal aortic aneurysms Redox Biol. (IF 10.787) Pub Date : 2022-08-17 Yixuan Zhang, Kin Lung Siu, Qiang Li, Kimberly Howard-Quijano, Jennifer Scovotti, Aman Mahajan, Hua Linda Cai
We have previously shown that circulating levels of tetrahydrobiopterin (H4B) function as a robust biomarker for aortic aneurysms in several independent animal models. Presently, we examined biomarker values of circulating H4B levels in human patients of TAA and AAA for the first time, while clinically applicable biomarkers for aortic aneurysms have been absent. Ninety-five patients scheduled for TAA
-
Endogenous H2S targets mitochondria to promote continual phagocytosis of erythrocytes by microglia after intracerebral hemorrhage Redox Biol. (IF 10.787) Pub Date : 2022-08-17 Xiaoling Yan, Meijun He, Hui Huang, Qi Wang, Yu Hu, Xiaoying Wang, Meng Jin, Yi Wang, Yiqing Xia, Yi Li, Gang Chen, Jian Cheng, Jia Jia
-
Mo3Se4 nanoparticle with ROS scavenging and multi-enzyme activity for the treatment of DSS-induced colitis in mice Redox Biol. (IF 10.787) Pub Date : 2022-08-14 Hongrui Guo, Hai Guo, Yue Xie, Yinyin Chen, Changfang Lu, Zhouping Yang, Yanqiu Zhu, Yujuan Ouyang, Yu Zhang, Xianxiang Wang
-
Macrophage SAMSN1 protects against sepsis-induced acute lung injury in mice Redox Biol. (IF 10.787) Pub Date : 2022-08-13 Wanli Jiang, Chengtai Ma, Jiawei Bai, Xianjin Du
Objective Inflammation and oxidative stress contribute to the progression of sepsis-induced acute lung injury (ALI). SAM domain, SH3 domain and nuclear localization signals 1 (SAMSN1) is a signaling adaptor protein, and mainly regulates inflammatory response of various immune cells. The present study generates macrophage-specific SAMSN1-knockout (Samsn1MKO) and SAMSN1-transgenic (Samsn1MTG) mice to
-
Recovery of reduced thiol groups by superoxide-mediated denitrosation of nitrosothiols Redox Biol. (IF 10.787) Pub Date : 2022-08-14 Stefan Schildknecht, Alex von Kriegsheim, Ksenija Vujacic-Mirski, Fabio Di Lisa, Volker Ullrich, Andreas Daiber
-
CXCL1-CXCR2 signalling mediates hypertensive retinopathy by inducing macrophage infiltration Redox Biol. (IF 10.787) Pub Date : 2022-08-13 Shuai Wang, Jie Bai, Yun-Long Zhang, Qiu-Yue Lin, Xiao Han, Wei-Kun Qu, Peng-Fei Zhang, Yu-Song Ge, Qi Zhao, Hui-Hua Li
Inflammation plays an important role in hypertensive retinal vascular injury and subsequent retinopathy. Monocyte chemotaxis via CXCL1-CXCR2 binding has been implicated in various cardiovascular diseases, but the function of CXCL1-CXCR2 signalling involved in retinopathy, which was investigated as angiotensin II (Ang II)-induced retinopathy, is unclear. In our study, we established a hypertensive retinopathy
-
LIX1-mediated changes in mitochondrial metabolism control the fate of digestive mesenchyme-derived cells Redox Biol. (IF 10.787) Pub Date : 2022-08-13 Amandine Guérin, Claire Angebault, Sandrina Kinet, Chantal Cazevieille, Manuel Rojo, Jérémy Fauconnier, Alain Lacampagne, Arnaud Mourier, Naomi Taylor, Pascal de Santa Barbara, Sandrine Faure
-
CircSV2b participates in oxidative stress regulation through miR-5107-5p-Foxk1-Akt1 axis in Parkinson's disease Redox Biol. (IF 10.787) Pub Date : 2022-08-12 Quancheng Cheng, Jianwei Wang, Man Li, Jinyu Fang, Huiru Ding, Jieyi Meng, Junwei Zhang, Xuan Fang, Huaicun Liu, Chao Ma, Chunhua Chen, Weiguang Zhang
-
Evolutionary and structural analyses of the NADPH oxidase family in eukaryotes reveal an initial calcium dependency Redox Biol. (IF 10.787) Pub Date : 2022-08-12 Marta Massari, Callum R. Nicoll, Sara Marchese, Andrea Mattevi, Maria Laura Mascotti
Reactive oxygen species (ROS) are unstable molecules generated by the partial reduction of dioxygen. NADPH oxidases are a ubiquitous family of enzymes devoted to ROS production. They fuel an array of physiological roles in different species and are chemically demanding enzymes requiring FAD, NADPH and heme prosthetic groups in addition to either calcium or a various number of cytosolic mediators for
-
Vitamin C deficiency induces hypoglycemia and cognitive disorder through S-nitrosylation-mediated activation of glycogen synthase kinase 3β Redox Biol. (IF 10.787) Pub Date : 2022-08-08 Yingying Shu, Chaochun Zou, Yuqing Cai, Qiangqiang He, Xiaowei Wu, Haibin Zhu, Meiyu Qv, Yunqi Chao, Chengyun Xu, Lanfang Tang, Ximei Wu
Vitamin C (VC, l-ascorbic acid) is an essential nutrient that plays a key role in metabolism and functions as a potent antioxidant in regulating the S-nitrosylation and denitrosylation of target proteins. The precise function of VC deprivation in glucose homeostasis is still unknown. In the absence of L-gulono-1,4-lactone oxidoreductase, an essential enzyme for the last step of VC synthesis, VC deprivation
-
Mitochondrial and redox modifications in early stages of Huntington's disease Redox Biol. (IF 10.787) Pub Date : 2022-08-10 Carla Lopes, I. Luísa Ferreira, Carina Maranga, Margarida Beatriz, Sandra I. Mota, José Sereno, João Castelhano, Antero Abrunhosa, Francisco Oliveira, Maura De Rosa, Michael Hayden, Mário N. Laço, Cristina Januário, Miguel Castelo Branco, A. Cristina Rego
-
Rapid and selective generation of H2S within mitochondria protects against cardiac ischemia-reperfusion injury Redox Biol. (IF 10.787) Pub Date : 2022-08-05 Jan Lj. Miljkovic, Nils Burger, Justyna M. Gawel, John F. Mulvey, Abigail A.I. Norman, Takanori Nishimura, Yoshiyuki Tsujihata, Angela Logan, Olga Sauchanka, Stuart T. Caldwell, Jordan L. Morris, Tracy A. Prime, Stefan Warrington, Julien Prudent, Georgina R. Bates, Dunja Aksentijević, Hiran A. Prag, Andrew M. James, Michael P. Murphy
Mitochondria-targeted H2S donors are thought to protect against acute ischemia-reperfusion (IR) injury by releasing H2S that decreases oxidative damage. However, the rate of H2S release by current donors is too slow to be effective upon administration following reperfusion. To overcome this limitation here we develop a mitochondria-targeted agent, MitoPerSulf that very rapidly releases H2S within mitochondria
-
Shining a light on SSP4: A comprehensive analysis and biological applications for the detection of sulfane sulfurs Redox Biol. (IF 10.787) Pub Date : 2022-08-09 Meg Shieh, Xiang Ni, Shi Xu, Stephen P. Lindahl, Moua Yang, Tetsuro Matsunaga, Robert Flaumenhaft, Takaaki Akaike, Ming Xian
-
Deep blue autofluorescence reflects the oxidation state of human transthyretin Redox Biol. (IF 10.787) Pub Date : 2022-08-09 Elżbieta Wieczorek, Zofia Wygralak, Sylwia Kędracka-Krok, Patrycja Bezara, Dominika Bystranowska, Piotr Dobryszycki, Andrzej Ożyhar
-
Nav1.8 in keratinocytes contributes to ROS-mediated inflammation in inflammatory skin diseases Redox Biol. (IF 10.787) Pub Date : 2022-08-05 Yiya Zhang, Yangfan Li, Lei Zhou, Xin Yuan, Yaling Wang, Qing Deng, Zhili Deng, San Xu, Qian Wang, Hongfu Xie, Ji Li
-
Phospholipid peroxidation inhibits autophagy via stimulating the delipidation of oxidized LC3-PE Redox Biol. (IF 10.787) Pub Date : 2022-08-05 Wen Li, Lian-Xiang Luo, Qing-Qing Zhou, Hai-Biao Gong, Yuan-Yuan Fu, Chang-Yu Yan, E. Li, Jie Sun, Zhuo Luo, Zhao-Jun Ding, Qiong-Yi Zhang, Han-Lu Mu, Yun-Feng Cao, Shu-Hua Ouyang, Hiroshi Kurihara, Yi-Fang Li, Wan-Yang Sun, Min Li, Rong-Rong He
-
The loss of pancreatic islet NADPH oxidase (NOX)2 improves islet transplantation Redox Biol. (IF 10.787) Pub Date : 2022-07-31 Selina Wrublewsky, Julia Glas, Christopher Carlein, Lisa Nalbach, Markus Daniel Alexander Hoffmann, Mandy Pack, Eloisa Aparecida Vilas-Boas, Nathan Ribot, Reinhard Kappl, Michael D. Menger, Matthias W. Laschke, Emmanuel Ampofo, Leticia Prates Roma
Islet transplantation is a promising treatment strategy for type 1 diabetes mellitus (T1DM) patients. However, oxidative stress-induced graft failure due to an insufficient revascularization is a major problem of this therapeutic approach. NADPH oxidase (NOX)2 is an important producer of reactive oxygen species (ROS) and several studies have already reported that this enzyme plays a crucial role in
-
Aspirin promotes RSL3-induced ferroptosis by suppressing mTOR/SREBP-1/SCD1-mediated lipogenesis in PIK3CA-mutatnt colorectal cancer Redox Biol. (IF 10.787) Pub Date : 2022-08-04 Hao Chen, Qinqin Qi, Nan Wu, Ying Wang, Qian Feng, Rong Jin, Lei Jiang
Ferroptosis, a new form of regulated cell death triggered by the iron-dependent peroxidation of phospholipids, is associated with cellular metabolism, redox homeostasis, and various signaling pathways related to cancer. Aspirin is a widely used non-steroidal anti-inflammatory drug (NSAID) and has been reported to show therapeutic benefit in cancers harboring oncogenic PIK3CA, which encodes the catalytic
-
NCOA4-mediated ferritinophagy is involved in ionizing radiation-induced ferroptosis of intestinal epithelial cells Redox Biol. (IF 10.787) Pub Date : 2022-07-30 Hao Zhou, Ya-Li Zhou, Jiu-Ang Mao, Lin-Feng Tang, Jie Xu, Zhen-Xin Wang, Yang He, Ming Li
Ferroptosis is a newly recognized form of regulated cell death that is characterized by severe lipid peroxidation initiated by iron overload and the generation of reactive oxygen species (ROS). However, the role of iron in ionizing radiation (IR)-induced intestinal injury has not been fully illustrated yet. In this study, we found that IR induced ferroptosis in intestinal epithelial cells, as indicated
-
Corrigendum to “An inhibitor of interaction between the transcription factor NRF2 and the E3 ubiquitin ligase adapter β-TrCP delivers anti-inflammatory responses in mouse liver” [Redox Biol. 55 (2022) 102396/PMID: 35839629] Redox Biol. (IF 10.787) Pub Date : 2022-08-02 Raquel Fernández-Ginés, José Antonio Encinar, John D. Hayes, Baldo Oliva, Maria Isabel Rodríguez-Franco, Ana I. Rojo, Antonio Cuadrado
Abstract not available
-
Soluble guanylyl cyclase mediates noncanonical nitric oxide signaling by nitrosothiol transfer under oxidative stress Redox Biol. (IF 10.787) Pub Date : 2022-08-02 Chuanlong Cui, Changgong Wu, Ping Shu, Tong Liu, Hong Li, Annie Beuve
-
Acute lymphoblastic leukemia necessitates GSH-dependent ferroptosis defenses to overcome FSP1-epigenetic silencing Redox Biol. (IF 10.787) Pub Date : 2022-07-31 Lucas B. Pontel, Alberto Bueno-Costa, Agustín E. Morellato, Juliana Carvalho Santos, Gaël Roué, Manel Esteller
-
Alexander disease GFAP R239C mutant shows increased susceptibility to lipoxidation and elicits mitochondrial dysfunction and oxidative stress Redox Biol. (IF 10.787) Pub Date : 2022-07-30 Álvaro Viedma-Poyatos, Patricia González-Jiménez, María A. Pajares, Dolores Pérez-Sala
-
Increased NOS coupling by the metabolite tetrahydrobiopterin (BH4) reduces preeclampsia/IUGR consequences Redox Biol. (IF 10.787) Pub Date : 2022-07-30 Laurent Chatre, Aurélien Ducat, Frank T. Spradley, Ana C. Palei, Christiane Chéreau, Betty Couderc, Kamryn C. Thomas, Anna R. Wilson, Lorena M. Amaral, Irène Gaillard, Céline Méhats, Isabelle Lagoutte, Sébastien Jacques, Francisco Miralles, Frédéric Batteux, Joey P. Granger, Miria Ricchetti, Daniel Vaiman
Preeclampsia (PE) is a high-prevalence pregnancy disease characterized by placental insufficiency, gestational hypertension, and proteinuria. Overexpression of the A isoform of the STOX1 transcription factor (STOX1A) recapitulates PE in mice, and STOX1A overexpressing trophoblasts recapitulate PE patients hallmarks in terms of gene expression and pathophysiology. STOX1 overexpression induces nitroso-redox
-
BPTF inhibition antagonizes colorectal cancer progression by transcriptionally inactivating Cdc25A Redox Biol. (IF 10.787) Pub Date : 2022-07-22 Ping Guo, Shijia Zu, Shilong Han, Wendan Yu, Guoqing Xue, Xiaona Lu, Hua Lin, Xinrui Zhao, Haibo Lu, Chunyu Hua, Xinyu Wan, Liyuan Ru, Ziyue Guo, Hanxiao Ge, Kuan Lv, Guohui Zhang, Wuguo Deng, Cheng Luo, Wei Guo
-
Regulation of hyperoxia-induced neonatal lung injury via post-translational cysteine redox modifications Redox Biol. (IF 10.787) Pub Date : 2022-07-19 Tong Zhang, Nicholas J. Day, Matthew Gaffrey, Karl K. Weitz, Kwame Attah, Patrice N. Mimche, Robert Paine, Wei-Jun Qian, My N. Helms
-
Vanadium pentoxide induced oxidative stress and cellular senescence in human lung fibroblasts Redox Biol. (IF 10.787) Pub Date : 2022-07-16 Xiaojia He, Zachery R. Jarrell, Yongliang Liang, Matthew Ryan Smith, Michael L. Orr, Lucian Marts, Young-Mi Go, Dean P. Jones
-
Deletion of cystathionine-γ-lyase in bone marrow-derived cells promotes colitis-associated carcinogenesis Redox Biol. (IF 10.787) Pub Date : 2022-07-21 Ketan K. Thanki, Paul Johnson, Edward J. Higgins, Manjit Maskey, Ches’Nique Phillips, Swetaleena Dash, Francisco Arroyo Almenas, Armita Abdollahi Govar, Bing Tian, Romain Villéger, Ellen Beswick, Rui Wang, Csaba Szabo, Celia Chao, Irina V. Pinchuk, Mark R. Hellmich, Katalin Módis
-
Role of the cystathionine β-synthase / H2S pathway in the development of cellular metabolic dysfunction and pseudohypoxia in down syndrome Redox Biol. (IF 10.787) Pub Date : 2022-07-21 Theodora Panagaki, Laszlo Pecze, Elisa B. Randi, Anni I. Nieminen, Csaba Szabo
Background Overexpression of the transsulfuration enzyme cystathionine-β-synthase (CBS), and overproduction of its product, hydrogen sulfide (H2S) are recognized as potential pathogenetic factors in Down syndrome (DS). The purpose of the study was to determine how the mitochondrial function and core metabolic pathways are affected by DS and how pharmacological inhibition of CBS affects these parameters
-
Compartmentalized regulation of NAD+ by Di (2-ethyl-hexyl) phthalate induces DNA damage in placental trophoblast Redox Biol. (IF 10.787) Pub Date : 2022-07-20 Shuai Zhao, Yun Hong, Yue-yue Liang, Xiao-lu Li, Jiang-chuan Shen, Cong-cong Sun, Ling-luo Chu, Jie Hu, Hua Wang, De-xiang Xu, Shi-chen Zhang, Dou-dou Xu, Tao Xu, Ling-li Zhao
-
Corrigendum to “Hypoxia-induced HIF-1α/lncRNA-PMAN inhibits ferroptosis by promoting the cytoplasmic translocation of ELAVL1 in peritoneal dissemination from gastric cancer” [Redox Biol. 52C (2022) 102312] Redox Biol. (IF 10.787) Pub Date : 2022-07-19 Zaihuan Lin, Jialin Song, Yuke Gao, Sihao Huang, Rongzhang Dou, Panyi Zhong, Guoquan Huang, Lei Han, Jinsen Zheng, Xinyao Zhang, Shuyi Wang, Bin Xiong
Abstract not available
-
The Q-junction and the inflammatory response are critical pathological and therapeutic factors in CoQ deficiency Redox Biol. (IF 10.787) Pub Date : 2022-07-15 Pilar González-García, María Elena Díaz-Casado, Agustín Hidalgo-Gutiérrez, Laura Jiménez-Sánchez, Mohammed Bakkali, Eliana Barriocanal-Casado, Germaine Escames, Riccardo Zenezini Chiozzi, Franziska Völlmy, Esther A. Zaal, Celia R. Berkers, Albert J.R. Heck, Luis C. López
-
Mitochondria-targeted anti-oxidant AntiOxCIN4 improved liver steatosis in Western diet-fed mice by preventing lipid accumulation due to upregulation of fatty acid oxidation, quality control mechanism and antioxidant defense systems Redox Biol. (IF 10.787) Pub Date : 2022-07-16 Ricardo Amorim, Inês C.M. Simões, José Teixeira, Fernando Cagide, Yaiza Potes, Pedro Soares, Adriana Carvalho, Ludgero C. Tavares, Sofia Benfeito, Susana P. Pereira, Rui F. Simões, Agnieszka Karkucinska-Wieckowska, Ivan Viegas, Sylwia Szymanska, Michał Dąbrowski, Justyna Janikiewicz, Teresa Cunha-Oliveira, Agnieszka Dobrzyń, Paulo J. Oliveira
-
Transfer of H2O2 from Mitochondria to the endoplasmic reticulum via Aquaporin-11 Redox Biol. (IF 10.787) Pub Date : 2022-07-16 Ilaria Sorrentino, Mauro Galli, Iria Medraño-Fernandez, Roberto Sitia
-
Inhibition of NLRP3-mediated crosstalk between hepatocytes and liver macrophages by geniposidic acid alleviates cholestatic liver inflammatory injury Redox Biol. (IF 10.787) Pub Date : 2022-07-14 Meng Song, Zijun Chen, Ruian Qiu, Tingwei Zhi, Wenmin Xie, Yingya Zhou, Nachuan Luo, Fuqian Chen, Fang Liu, Chuangpeng Shen, Sheng Lin, Fengxue Zhang, Yong Gao, Changhui Liu
-
TRPM7 channel inhibition attenuates rheumatoid arthritis articular chondrocyte ferroptosis by suppression of the PKCα-NOX4 axis Redox Biol. (IF 10.787) Pub Date : 2022-07-19 Renpeng Zhou, Yong Chen, Shufang Li, Xin Wei, Weirong Hu, Su'an Tang, Jie Ding, Wanjin Fu, Hailin Zhang, Fan Chen, Wenjuan Hao, Yi Lin, Rendi Zhu, Ke Wang, Lei Dong, Yingjie Zhao, Xiaowen Feng, Feihu Chen, Wei Hu
-
Emerging roles of ER-resident selenoproteins in brain physiology and physiopathology Redox Biol. (IF 10.787) Pub Date : 2022-07-19 Cédric Jehan, Dorthe Cartier, Christine Bucharles, Youssef Anouar, Isabelle Lihrmann
The brain has a very high oxygen consumption rate and is particularly sensitive to oxidative stress. It is also the last organ to suffer from a loss of selenium (Se) in case of deficiency. Se is a crucial trace element present in the form of selenocysteine, the 21st proteinogenic amino acid present in selenoproteins, an essential protein family in the brain that participates in redox signaling. Among
-
Cytoglobin inhibits non-thermal plasma-induced apoptosis in melanoma cells through regulation of the NRF2-mediated antioxidant response Redox Biol. (IF 10.787) Pub Date : 2022-07-14 Joey De Backer, Abraham Lin, Wim Vanden Berghe, Annemie Bogaerts, David Hoogewijs
Melanoma arises from pigment-producing cells called melanocytes located in the basal layers of the epidermis of the skin. Cytoglobin (CYGB) is a ubiquitously expressed hexacoordinated globin that is highly enriched in melanocytes and frequently downregulated during melanomagenesis. Previously, we showed that non-thermal plasma (NTP)-produced reactive oxygen and nitrogen species (RONS) lead to the formation
-
Integrated regulation of stress responses, autophagy and survival by altered intracellular iron stores Redox Biol. (IF 10.787) Pub Date : 2022-07-14 Yunyang Wang, Mo Wang, Yunshan Liu, Hui Tao, Somesh Banerjee, Shanthi Srinivasan, Elizabeta Nemeth, Mark J. Czaja, Peijian He
Iron is a mineral essential for blood production and a variety of critical cellular functions. Altered iron metabolism has been increasingly observed in many diseases and disorders, but a comprehensive and mechanistic understanding of the cellular impact of impaired iron metabolism is still lacking. We examined the effects of iron overload or iron deficiency on cellular stress responses and autophagy
-
An inhibitor of interaction between the transcription factor NRF2 and the E3 ubiquitin ligase adapter β-TrCP delivers anti-inflammatory responses in mouse liver Redox Biol. (IF 10.787) Pub Date : 2022-07-11 Raquel Fernández-Ginés, José Antonio Encinar, John D. Hayes, Baldo Oliva, Maria Isabel Rodríguez-Franco, Ana I. Rojo, Antonio Cuadrado
-
Stable isotope dilution mass spectrometry quantification of hydrogen sulfide and thiols in biological matrices Redox Biol. (IF 10.787) Pub Date : 2022-07-13 Hind Malaeb, Ibrahim Choucair, Zeneng Wang, Xinmin S. Li, Lin Li, W. Christopher Boyd, Christopher Hine, W.H. Wilson Tang, Valentin Gogonea, Stanley L. Hazen
Background Hydrogen sulfide (H2S), a gaseous signaling molecule that impacts multiple physiological processes including aging, is produced via select mammalian enzymes and enteric sulfur-reducing bacteria. H2S research is limited by the lack of an accurate internal standard-containing assay for its quantitation in biological matrices. Methods After synthesizing [34S]H2S and developing sample preparation
-
Corrigendum to “Cellular redox imbalance on the crossroad between mitochondrial dysfunction, senescence, and proliferation” [Redox Biol. 53 (2022) 102337] Redox Biol. (IF 10.787) Pub Date : 2022-07-09 Rumiana Bakalova, Ichio Aoki, Zhivko Zhelev, Tatsuya Higashi
Abstract not available
-
Nox4 promotes endothelial differentiation through chromatin remodeling Redox Biol. (IF 10.787) Pub Date : 2022-07-06 F. Hahner, F. Moll, T. Warwick, D.M. Hebchen, G.K. Buchmann, J. Epah, W. Abplanalp, T. Schader, S. Günther, R. Gilsbach, R.P. Brandes, K. Schröder
Rationale Nox4 is a constitutively active NADPH oxidase that constantly produces low levels of H2O2. Thereby, Nox4 contributes to cell homeostasis and long-term processes, such as differentiation. The high expression of Nox4 seen in endothelial cells contrasts with the low abundance of Nox4 in stem cells, which are accordingly characterized by low levels of H2O2. We hypothesize that Nox4 is a major
-
Fast regulation of the NF-κB signalling pathway in human skeletal muscle revealed by high-intensity exercise and ischaemia at exhaustion: Role of oxygenation and metabolite accumulation Redox Biol. (IF 10.787) Pub Date : 2022-07-08 Angel Gallego-Selles, Victor Galvan-Alvarez, Miriam Martinez-Canton, Eduardo Garcia-Gonzalez, David Morales-Alamo, Alfredo Santana, Juan Jose Gonzalez-Henriquez, Cecilia Dorado, Jose A.L. Calbet, Marcos Martin-Rincon
-
Induction of 2-hydroxycatecholestrogens O-methylation: A missing puzzle piece in diagnostics and treatment of lung cancer Redox Biol. (IF 10.787) Pub Date : 2022-07-08 Claudia Musial, Narcyz Knap, Renata Zaucha, Paulina Bastian, Giampaolo Barone, Giosuè Lo Bosco, Fabrizio Lo-Celso, Lucyna Konieczna, Mariusz Belka, Tomasz Bączek, Antonella Marino Gammazza, Alicja Kuban-Jankowska, Francesco Cappello, Stephan Nussberger, Magdalena Gorska-Ponikowska
-
Vitamin A aldehyde-taurine adducts function in photoreceptor cells Redox Biol. (IF 10.787) Pub Date : 2022-07-03 Hye Jin Kim, Jin Zhao, Janet R. Sparrow
-
Protein palmitoylation-mediated palmitic acid sensing causes blood-testis barrier damage via inducing ER stress Redox Biol. (IF 10.787) Pub Date : 2022-07-02 Xie Ge, Zhaowanyue He, Chun Cao, Tongmin Xue, Jun Jing, Rujun Ma, Wei Zhao, Ling Liu, Kadiliya Jueraitetibaike, Jinzhao Ma, Yuming Feng, Zhang Qian, Zhichuan Zou, Li Chen, Chuanhai Fu, Ninghong Song, Bing Yao
-
Long noncoding RNA MAGI2-AS3 regulates the H2O2 level and cell senescence via HSPA8 Redox Biol. (IF 10.787) Pub Date : 2022-06-30 Yingmin Zhang, Xinhua Qiao, Lihui Liu, Wensheng Han, Qinghua Liu, Yuanyuan Wang, Ting Xie, Yiheng Tang, Tiepeng Wang, Jiao Meng, Aojun Ye, Shunmin He, Runsheng Chen, Chang Chen
-
Dissecting the process of human neutrophil lineage determination by using alpha-lipoic acid inducing neutrophil deficiency model Redox Biol. (IF 10.787) Pub Date : 2022-07-02 Yong Dong, Yimeng Zhang, Yongping Zhang, Xu Pan, Ju Bai, Yijin Chen, Ya Zhou, Zhenyang Lai, Qiang Chen, Shaoyan Hu, Qiongxiu Zhou, Yonggang Zhang, Feng Ma
Granulocyte-monocyte progenitors (GMPs) differentiate into both neutrophils and monocytes. Recently, uni-potential neutrophil progenitors have been identified both in mice and humans using an array of surface markers. However, how human GMPs commit to neutrophil progenitors and the regulatory mechanisms of fate determination remain incompletely understood. In the present study, we established a human
-
Corrigendum to “A CRISPR screen identifies redox vulnerabilities for KEAP1/NRF2 mutant non-small cell lung cancer” [Redox Biol. 54 (2022) 102358] Redox Biol. (IF 10.787) Pub Date : 2022-07-03 Chang Jiang, Nathan P. Ward, Nicolas Prieto-Farigua, Yun Pyo Kang, Anish Thalakola, Mingxiang Teng, Gina M. DeNicola
Abstract not available
-
Signal amplification in the KEAP1-NRF2-ARE antioxidant response pathway Redox Biol. (IF 10.787) Pub Date : 2022-06-30 Shengnan Liu, Jingbo Pi, Qiang Zhang
The KEAP1-NRF2-ARE signaling pathway plays a central role in mediating the adaptive cellular stress response to oxidative and electrophilic chemicals. This canonical pathway has been extensively studied and reviewed in the past two decades, but rarely was it looked at from a quantitative signaling perspective. Signal amplification, i.e., ultrasensitivity, is crucially important for robust induction
-
Structural snapshots of nitrosoglutathione binding and reactivity underlying S-nitrosylation of photosynthetic GAPDH Redox Biol. (IF 10.787) Pub Date : 2022-06-30 Edoardo Jun Mattioli, Jacopo Rossi, Maria Meloni, Marcello De Mia, Christophe H. Marchand, Andrea Tagliani, Silvia Fanti, Giuseppe Falini, Paolo Trost, Stéphane D. Lemaire, Simona Fermani, Matteo Calvaresi, Mirko Zaffagnini
S-nitrosylation is a redox post-translational modification widely recognized to play an important role in cellular signaling as it can modulate protein function and conformation. At the physiological level, nitrosoglutathione (GSNO) is considered the major physiological NO-releasing compound due to its ability to transfer the NO moiety to protein thiols but the structural determinants regulating its
-
Adiponectin/AdiopR1 signaling prevents mitochondrial dysfunction and oxidative injury after traumatic brain injury in a SIRT3 dependent manner Redox Biol. (IF 10.787) Pub Date : 2022-06-30 Shenghao Zhang, Xun Wu, Jin Wang, Yingwu Shi, Qing Hu, Wenxing Cui, Hao Bai, Jinpeng Zhou, Yong Du, Liying Han, Leiyang Li, Dayun Feng, Shunnan Ge, Yan Qu
Mitochondrial dysfunction and oxidative injury, which contribute to worsening of neurological deficits and poor clinical outcomes, are hallmarks of secondary brain injury after TBI. Adiponectin (APN), beyond its well-established regulatory effects on metabolism, is also essential for maintaining normal brain functions by binding APN receptors that are ubiquitously expressed in the brain. Currently
-
Genetic determinants of fungi-induced ROS production are associated with the risk of invasive pulmonary aspergillosis Redox Biol. (IF 10.787) Pub Date : 2022-07-04 Vasiliki Matzaraki, Alexandra Beno, Martin Jaeger, Mark S. Gresnigt, Nick Keur, Collins Boahen, Cristina Cunha, Samuel M. Gonçalves, Luis Leite, João F. Lacerda, António Campos, Frank L. van de Veerdonk, Leo Joosten, Mihai G. Netea, Agostinho Carvalho, Vinod Kumar
-
Induction of reactive oxygen species by mechanical stretch drives endothelin production in neonatal pig renal epithelial cells Redox Biol. (IF 10.787) Pub Date : 2022-07-04 Ravi Kumar, Hitesh Soni, Jeremiah M. Afolabi, Praghalathan Kanthakumar, Pratheesh D. Mankuzhy, Samson A. Iwhiwhu, Adebowale Adebiyi
-
Measuring peroxidasin activity in live cells using bromide addition for signal amplification Redox Biol. (IF 10.787) Pub Date : 2022-06-30 Veronika F.S. Pape, Hajnal A. Kovács, István Szatmári, Imre Ugrai, Bence Szikora, Imre Kacskovics, Zoltán May, Norbert Szoboszlai, Gábor Sirokmány, Miklós Geiszt
-
The m6A reader YTHDF3-mediated PRDX3 translation alleviates liver fibrosis Redox Biol. (IF 10.787) Pub Date : 2022-06-24 Ruimin Sun, Xinyao Tian, Yang Li, Yan Zhao, Zhecheng Wang, Yan Hu, Lijun Zhang, Yue Wang, Dongyan Gao, Shusen Zheng, Jihong Yao
-
Transketolase in human Müller cells is critical to resist light stress through the pentose phosphate and NRF2 pathways Redox Biol. (IF 10.787) Pub Date : 2022-06-24 Yingying Chen, Ting Zhang, Shaoxue Zeng, Rong Xu, Kaiyu Jin, Nathan J. Coorey, Yekai Wang, Ke Wang, So-Ra Lee, Michelle Yam, Meidong Zhu, Andrew Chang, Xiaohui Fan, Meixia Zhang, Jianhai Du, Mark C. Gillies, Ling Zhu
-
Remission of obesity and insulin resistance is not sufficient to restore mitochondrial homeostasis in visceral adipose tissue Redox Biol. (IF 10.787) Pub Date : 2022-06-24 Alba Gonzalez-Franquesa, Pau Gama-Perez, Marta Kulis, Karolina Szczepanowska, Norma Dahdah, Sonia Moreno-Gomez, Ana Latorre-Pellicer, Rebeca Fernández-Ruiz, Antoni Aguilar-Mogas, Anne Hoffman, Erika Monelli, Sara Samino, Joan Miró-Blanch, Gregor Oemer, Xavier Duran, Estrella Sanchez-Rebordelo, Marc Schneeberger, Merce Obach, Pablo M. Garcia-Roves
Metabolic plasticity is the ability of a biological system to adapt its metabolic phenotype to different environmental stressors. We used a whole-body and tissue-specific phenotypic, functional, proteomic, metabolomic and transcriptomic approach to systematically assess metabolic plasticity in diet-induced obese mice after a combined nutritional and exercise intervention. Although most obesity and