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Redox regulation of macrophages Redox Biol. (IF 11.4) Pub Date : 2024-03-12 Nhien Tran, Evanna L. Mills
Redox signaling, a mode of signal transduction that involves the transfer of electrons from a nucleophilic to electrophilic molecule, has emerged as an essential regulator of inflammatory macrophages. Redox reactions are driven by reactive oxygen/nitrogen species (ROS and RNS) and redox-sensitive metabolites such as fumarate and itaconate which can post-translationally modify specific cysteine residues
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MASLD is related to impaired alcohol dehydrogenase (ADH) activity and elevated blood ethanol levels: Role of TNFα and JNK Redox Biol. (IF 11.4) Pub Date : 2024-03-12 Katharina Burger, Finn Jung, Katharina Staufer, Ruth Ladurner, Michael Trauner, Anja Baumann, Annette Brandt, Ina Bergheim
Elevated fasting ethanol levels in peripheral blood frequently found in MASLD patients even in the absence of alcohol consumption are discussed to contribute to disease development. To test the hypothesis that besides an enhanced gastrointestinal synthesis a diminished alcohol elimination through alcohol dehydrogenase (ADH) may also be critical herein, we determined fasting ethanol levels and ADH activity
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Hybrid molecules synergistically mitigate ferroptosis and amyloid-associated toxicities in Alzheimer's disease Redox Biol. (IF 11.4) Pub Date : 2024-03-11 Dikshaa Padhi, Prayasee Baruah, Madhu Ramesh, Hariharan Moorthy, Thimmaiah Govindaraju
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the build-up of extracellular amyloid β (Aβ) plaques and intracellular neurofibrillary tangles (NFTs). Ferroptosis, an iron (Fe)-dependent form of cell death plays a significant role in the multifaceted AD pathogenesis through generation of reactive oxygen species (ROS), mitochondrial damage, lipid peroxidation, and reduction
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Itaconic acid regulation of TFEB-mediated autophagy flux alleviates hyperoxia-induced bronchopulmonary dysplasia Redox Biol. (IF 11.4) Pub Date : 2024-03-11 Chengbo Liu, Changchang Fu, Yazhou Sun, You You, Tengfei Wang, Yongjun Zhang, Hongping Xia, Xingyun Wang
Premature infants often require oxygen supplementation, which can elicit bronchopulmonary dysplasia (BPD) and lead to mitochondrial dysfunction. Mitochondria play important roles in lung development, in both normal metabolism and apoptosis. Enhancing our comprehension of the underlying mechanisms in BPD development can facilitate the effective treatments. Plasma samples from BPD and non-BPD infants
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The cytosolic hyperoxidation-sensitive and -robust Leishmania peroxiredoxins cPRX1 and cPRX2 are both dispensable for parasite infectivity Redox Biol. (IF 11.4) Pub Date : 2024-03-10 Helena Castro, Maria Inês Rocha, Margarida Duarte, Jordi Vilurbina, Ana Georgina Gomes-Alves, Teresa Leao, Filipa Dias, Bruce Morgan, Marcel Deponte, Ana Maria Tomás
Typical two-cysteine peroxiredoxins (2-Cys-PRXs) are HO-metabolizing enzymes whose activity relies on two cysteine residues. Protists of the family invariably express one cytosolic 2-Cys-PRX (cPRX1). However, the sub-family features an additional isoform (cPRX2), almost identical to cPRX1, except for the lack of an elongated C-terminus with a Tyr-Phe (YF) motif. Previously, cytosolic PRXs were considered
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Was H2O2 generated before oxygenic photosynthesis? Redox Biol. (IF 11.4) Pub Date : 2024-03-09 Willem H. Koppenol, Helmut Sies
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ATF3-CBS signaling axis coordinates ferroptosis and tumorigenesis in colorectal cancer Redox Biol. (IF 11.4) Pub Date : 2024-03-08 Junjia Liu, Xinyi Lu, Siyu Zeng, Rong Fu, Xindong Wang, Lingtao Luo, Ting Huang, Xusheng Deng, Hualei Zheng, Shaoqian Ma, Dan Ning, Lili Zong, Shu-Hai Lin, Yongyou Zhang
The induction of ferroptosis is promising for cancer therapy. However, the mechanisms enabling cancer cells to evade ferroptosis, particularly in low-cystine environments, remain elusive. Our study delves into the intricate regulatory mechanisms of Activating transcription factor 3 (ATF3) on Cystathionine β-synthase (CBS) under cystine deprivation stress, conferring resistance to ferroptosis in colorectal
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IL-13 facilitates ferroptotic death in asthmatic epithelial cells via SOCS1-mediated ubiquitinated degradation of SLC7A11 Redox Biol. (IF 11.4) Pub Date : 2024-03-08 Manli Miao, Min Pan, Xu Chen, Jiapan Shen, Ling Zhang, Xiaoxia Feng, Mengting Chen, Guofeng Cui, Huaiyuan Zong, Wen Zhang, Shuang Chang, Fangzhou Xu, Zixi Wang, Dapeng Li, Weiwei Liu, Zhao Ding, Shengquan Zhang, Biao Chen, Xiaojun Zha, Xiaoyun Fan
Th2-high asthma is characterized by elevated levels of type 2 cytokines, such as interleukin 13 (IL-13), and its prevalence has been increasing worldwide. Ferroptosis, a recently discovered type of programmed cell death, is involved in the pathological process of Th2-high asthma; however, the underlying mechanisms remain incompletely understood. In this study, we demonstrated that the serum level of
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Inhibition of glycogen synthase kinase-3 enhances NRF2 protein stability, nuclear localisation and target gene transcription in pancreatic beta cells Redox Biol. (IF 11.4) Pub Date : 2024-03-07 Chinmai Patibandla, Lidy van Aalten, Albena T. Dinkova-Kostova, Tadashi Honda, Antonio Cuadrado, Raquel Fernández-Ginés, Alison D. McNeilly, John D. Hayes, James Cantley, Calum Sutherland
Accumulation of reactive oxygen species (i.e., oxidative stress) is a leading cause of beta cell dysfunction and apoptosis in diabetes. NRF2 (NF-E2 p45-related factor-2) regulates the adaptation to oxidative stress, and its activity is negatively regulated by the redox-sensitive CUL3 (cullin-3) ubiquitin ligase substrate adaptor KEAP1 (Kelch-like ECH-associated protein-1). Additionally, NRF2 is repressed
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GSTP alleviates acute lung injury by S-glutathionylation of KEAP1 and subsequent activation of NRF2 pathway Redox Biol. (IF 11.4) Pub Date : 2024-03-06 Xiaolin Sun, Chaorui Guo, Chunyan Huang, Ning Lv, Huili Chen, Haoyan Huang, Yulin Zhao, Shanliang Sun, Di Zhao, Jingwei Tian, Xijing Chen, Yongjie Zhang
Oxidative stress plays an important role in the pathogenesis of acute lung injury (ALI). As a typical post-translational modification triggered by oxidative stress, protein -glutathionylation (PSSG) is regulated by redox signaling pathways and plays diverse roles in oxidative stress conditions. In this study, we found that GSTP downregulation exacerbated LPS-induced injury in human lung epithelial
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ERRγ-inducible FGF23 promotes alcoholic liver injury through enhancing CYP2E1 mediated hepatic oxidative stress Redox Biol. (IF 11.4) Pub Date : 2024-03-05 Yoon Seok Jung, Kamalakannan Radhakrishnan, Seddik Hammad, Sebastian Müller, Johannes Müller, Jung-Ran Noh, Jina kim, In-Kyu Lee, Sung Jin Cho, Don-Kyu Kim, Yong-Hoon Kim, Chul-Ho Lee, Steven Dooley, Hueng-Sik Choi
Fibroblast growth factor 23 (FGF23) is a member of endocrine FGF family, along with FGF15/19 and FGF21. Recent reports showed that under pathological conditions, liver produces FGF23, although the role of hepatic FGF23 remains nebulous. Here, we investigated the role of hepatic FGF23 in alcoholic liver disease (ALD) and delineated the underlying molecular mechanism. FGF23 expression was compared in
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Role of Selenoprotein W in participating in the progression of non-alcoholic fatty liver disease Redox Biol. (IF 11.4) Pub Date : 2024-03-05 Zhiruo Miao, Wei Wang, Zhiying Miao, Qiyuan Cao, Shiwen Xu
Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease worldwide. Numerous evidence has demonstrated that metabolic reprogramming serves as a hallmark associated with an elevated risk of NAFLD progression. Selenoprotein W (SelW) is an extensively expressed hepatic selenoprotein that plays a crucial role in antioxidant function. Here, we first demonstrated that SelW is a significantly
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Development of dietary small molecules as multi-targeting treatment strategies for Alzheimer's disease Redox Biol. (IF 11.4) Pub Date : 2024-03-04 Rengasamy Balakrishnan, Khoshnur Jannat, Dong-Kug Choi
Cognitive dysfunction can occur both in normal aging and age-related neurological disorders, such as mild cognitive impairment and Alzheimer's disease (AD). These disorders have few treatment options due to side effects and limited efficacy. New approaches to slow cognitive decline are urgently needed. Dietary interventions (nutraceuticals) have received considerable attention because they exhibit
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Nuclear translocation of metabolic enzyme PKM2 participates in high glucose-promoted HCC metastasis by strengthening immunosuppressive environment Redox Biol. (IF 11.4) Pub Date : 2024-03-04 Jiali Qian, Chuxin Huang, Mimi Wang, Ying Liu, Yingying Zhao, Miao Li, Xi Zhang, Xiangyu Gao, Yawen Zhang, Yi Wang, Jinya Huang, Jiajun Li, Qiwen Zhou, Rui Liu, Xuanchun Wang, Jiefeng Cui, Yehong Yang
Although some cohort studies have indicated a close association between diabetes and HCC, the underlying mechanism about the contribution of diabetes to HCC progression remains largely unknown. In the study, we applied a novel HCC model in SD rat with diabetes and a series of high glucose-stimulated cell experiments to explore the effect of a high glucose environment on HCC metastasis and its relevant
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Enteric coronavirus PDCoV evokes a non-Warburg effect by hijacking pyruvic acid as a metabolic hub Redox Biol. (IF 11.4) Pub Date : 2024-03-04 Guanning Su, Jiao Liu, Chenrui Duan, Puxian Fang, Liurong Fang, Yanrong Zhou, Shaobo Xiao
The Warburg effect, also referred as aerobic glycolysis, is a common metabolic program during viral infection. Through targeted metabolomics combined with biochemical experiments and various cell models, we investigated the central carbon metabolism (CCM) profiles of cells infected with porcine deltacoronavirus (PDCoV), an emerging enteropathogenic coronavirus with zoonotic potential. We found that
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Human papillomavirus-16 E6 activates the pentose phosphate pathway to promote cervical cancer cell proliferation by inhibiting G6PD lactylation Redox Biol. (IF 11.4) Pub Date : 2024-03-01 Qingfei Meng, Yanghe Zhang, Huihui Sun, Xiangzhe Yang, Shiming Hao, Bin Liu, Honglan Zhou, Yishu Wang, Zhi-Xiang Xu
High-risk human papillomaviruses (HPVs) are the causative agents of cervical cancer. Here, we report that HPV16 E6E7 promotes cervical cancer cell proliferation by activating the pentose phosphate pathway (PPP). We found that HPV16 E6 activates the PPP primarily by increasing glucose-6-phosphate dehydrogenase (G6PD) enzyme activity. Mechanistically, HPV16 E6 promoted G6PD dimer formation by inhibiting
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Redox homeostasis in cardiac fibrosis: Focus on metal ion metabolism Redox Biol. (IF 11.4) Pub Date : 2024-03-01 Zhen-Yu Liu, Zhi-Yan Liu, Li-Chan Lin, Kai Song, Bin Tu, Ye Zhang, Jing-Jing Yang, Jian-Yuan Zhao, Hui Tao
Cardiac fibrosis is a major public health problem worldwide, with high morbidity and mortality, affecting almost all patients with heart disease worldwide. It is characterized by fibroblast activation, abnormal proliferation, excessive deposition, and abnormal distribution of extracellular matrix (ECM) proteins. The maladaptive process of cardiac fibrosis is complex and often involves multiple mechanisms
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Control of the signaling role of PtdIns(4)P at the plasma membrane through H2O2-dependent inactivation of synaptojanin 2 during endocytosis Redox Biol. (IF 11.4) Pub Date : 2024-02-29 Su In Jo, Suree Kim, Jung Mi Lim, Sue Goo Rhee, Bo-Gyeong Jeong, Sun-Shin Cha, Jae-Byum Chang, Dongmin Kang
Phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P] is implicated in various processes, including hormone-induced signal transduction, endocytosis, and exocytosis in the plasma membrane. However, how HO accumulation regulates the levels of PtdIns(4,5)P in the plasma membrane in cells stimulated with epidermal growth factors (EGFs) is not known. We show that a plasma membrane PtdIns(4,5)P-degrading
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Covalent organic framework based cytoprotective therapy after ischemic stroke Redox Biol. (IF 11.4) Pub Date : 2024-02-28 Yuqin Peng, Qingfan Ren, Huanrong Ma, Chuman Lin, Mingjia Yu, Yongchuan Li, Jiancong Chen, Haihao Xu, Peng Zhao, Suyue Pan, Jia Tao, Kaibin Huang
Cytoprotection has emerged as an effective therapeutic strategy for mitigating brain injury following acute ischemic stroke (AIS). The sulfonylurea receptor 1-transient receptor potential M4 (SUR1-TRPM4) channel plays a pivotal role in brain edema and neuroinflammation. However, the practical use of the inhibitor glyburide (GLB) is hindered by its low bioavailability. Additionally, the elevated reactive
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Inhibition of MST1 ameliorates neuronal apoptosis via GSK3β/β-TrCP/NRF2 pathway in spinal cord injury accompanied by diabetes Redox Biol. (IF 11.4) Pub Date : 2024-02-28 Weijun Huang, Depeng Wu, Chaoyang Cai, Hui Yao, Zhenming Tian, Yang Yang, Mao Pang, Limin Rong, Bin Liu
Spinal cord injury (SCI) is a devastating neurological disease that often results in tremendous loss of motor function. Increasing evidence demonstrates that diabetes worsens outcomes for patients with SCI due to the higher levels of neuronal oxidative stress. Mammalian sterile 20-like kinase (MST1) is a key mediator of oxidative stress in the central nervous system; however, the mechanism of its action
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Low-molecular-weight thiol transferases in redox regulation and antioxidant defence Redox Biol. (IF 11.4) Pub Date : 2024-02-24 Maria-Armineh Tossounian, Yuhan Zhao, Bess Yi Kun Yu, Samuel A. Markey, Oksana Malanchuk, Yuejia Zhu, Amanda Cain, Ivan Gout
Low-molecular-weight (LMW) thiols are produced in all living cells in different forms and concentrations. Glutathione (GSH), coenzyme A (CoA), bacillithiol (BSH), mycothiol (MSH), ergothioneine (ET) and trypanothione T(SH) are the main LMW thiols in eukaryotes and prokaryotes. LMW thiols serve as electron donors for thiol-dependent enzymes in redox-mediated metabolic and signaling processes, protect
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Identification of tyrosine brominated extracellular matrix proteins in normal and fibrotic lung tissues Redox Biol. (IF 11.4) Pub Date : 2024-02-23 Litiele Cezar Cruz, Aida Habibovic, Bianca Dempsey, Mariana P. Massafera, Yvonne M.W. Janssen-Heininger, Miao-chong Joy Lin, Evan T. Hoffman, Daniel J. Weiss, Steven K. Huang, Albert van der Vliet, Flavia C. Meotti
Peroxidasin (PXDN) is a secreted heme peroxidase that catalyzes the oxidative crosslinking of collagen IV within the extracellular matrix (ECM) via intermediate hypobromous acid (HOBr) synthesis from hydrogen peroxide and bromide, but recent findings have also suggested alternative ECM protein modifications by PXDN, including incorporation of bromide into tyrosine residues. In this work, we sought
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Corrigendum to “Empagliflozin rescues diabetic myocardial microvascular injury via AMPK-mediated inhibition of mitochondrial fission” [Redox Biol. 15 (2018) 335–346] Redox Biol. (IF 11.4) Pub Date : 2024-02-22 Hao Zhou, Shuyi Wang, Pingjun Zhu, Shunying Hu, Yundai Chen, Jun Ren
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Aerobic exercise attenuates LPS-induced cognitive dysfunction by reducing oxidative stress, glial activation, and neuroinflammation Redox Biol. (IF 11.4) Pub Date : 2024-02-22 Jae-Won Choi, Sang-Woo Jo, Dae-Eun Kim, Il-Young Paik, Rengasamy Balakrishnan
Physical activity has been considered an important non-medication intervention in preserving mnemonic processes during aging. However, how aerobic exercise promotes such benefits for human health remains unclear. In this study, we aimed to explore the neuroprotective and anti-inflammatory effects of aerobic exercise against lipopolysaccharide (LPS)-induced amnesic C57BL/6J mice and BV-2 microglial
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Factors driving the inter-individual variability in the metabolism and bioavailability of (poly)phenolic metabolites: A systematic review of human studies Redox Biol. (IF 11.4) Pub Date : 2024-02-20 Claudia Favari, José Fernando Rinaldi de Alvarenga, Lorena Sánchez-Martínez, Nicole Tosi, Cristiana Mignogna, Eleonora Cremonini, Claudine Manach, Letizia Bresciani, Daniele Del Rio, Pedro Mena
This systematic review provides an overview of the available evidence on the inter-individual variability (IIV) in the absorption, distribution, metabolism, and excretion (ADME) of phenolic metabolites and its determinants. Human studies were included investigating the metabolism and bioavailability of (poly)phenols and reporting IIV. One hundred fifty-three studies met the inclusion criteria. Inter-individual
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Excessive linoleic acid induces muscle oxidative stress through 5-lipoxygenase-dependent peroxidation Redox Biol. (IF 11.4) Pub Date : 2024-02-19 Xiufei Cao, Huixing Guo, Yongjun Dai, Guangzhen Jiang, Wenbin Liu, Xiangfei Li, Dingdong Zhang, Yangyang Huang, Xi Wang, Haokun Hua, Jianfeng Wang, Keke Chen, Cheng Chi, Hengtong Liu
Oxidative stress in muscles is closely related to the occurrence of insulin resistance, muscle weakness and atrophy, age-related sarcopenia, and cancer. Aldehydes, a primary oxidation intermediate of polyunsaturated fatty acids, have been proven to be an important trigger for oxidative stress. However, the potential role of linoleic acid (LA) as a donor for volatile aldehydes to trigger oxidative stress
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SOD2 orchestrates redox homeostasis in intervertebral discs: A novel insight into oxidative stress-mediated degeneration and therapeutic potential Redox Biol. (IF 11.4) Pub Date : 2024-02-19 Shota Tamagawa, Daisuke Sakai, Hidetoshi Nojiri, Yoshihiko Nakamura, Takayuki Warita, Erika Matsushita, Jordy Schol, Hazuki Soma, Shota Ogasawara, Daiki Munesada, Masato Koike, Takahiko Shimizu, Masato Sato, Muneaki Ishijima, Masahiko Watanabe
Low back pain (LBP) is a pervasive global health concern, primarily associated with intervertebral disc (IVD) degeneration. Although oxidative stress has been shown to contribute to IVD degeneration, the underlying mechanisms remain undetermined. This study aimed to unravel the role of superoxide dismutase 2 (SOD2) in IVD pathogenesis and target oxidative stress to limit IVD degeneration. SOD2 demonstrated
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Tumor associated macrophages transfer ceruloplasmin mRNA to fibrosarcoma cells and protect them from ferroptosis Redox Biol. (IF 11.4) Pub Date : 2024-02-17 Anna Schwantes, Anja Wickert, Sabrina Becker, Patrick C. Baer, Andreas Weigert, Bernhard Brüne, Dominik C. Fuhrmann
Solid tumors are characterized by hypoxic areas, which are prone for macrophage infiltration. Once infiltrated, macrophages polarize to tumor associated macrophages (TAM) to support tumor progression. Therefore, the crosstalk between TAMs and tumor cells is of current interest for the development of novel therapeutic strategies. These may comprise induction of an iron- and lipid peroxidation-dependent
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Corrigendum to “miR-484 mediates oxidative stress-induced ovarian dysfunction and promotes granulosa cell apoptosis via SESN2 downregulation” [Redox Biol. 62 (2023)1–16 102684] Redox Biol. (IF 11.4) Pub Date : 2024-02-16 Xiaofei Wang, Jiahao Yang, Huiying Li, Hongbei Mu, Ling Zeng, Siying Cai, Ping Su, Huaibiao Li, Ling Zhang, Wenpei Xiang
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Gut microbiome, short-chain fatty acids, alpha-synuclein, neuroinflammation, and ROS/RNS: Relevance to Parkinson's disease and therapeutic implications Redox Biol. (IF 11.4) Pub Date : 2024-02-16 Balaraman Kalyanaraman, Gang Cheng, Micael Hardy
In this review, we explore how short-chain fatty acids (SCFAs) produced by the gut microbiome affect Parkinson's disease (PD) through their modulatory interactions with alpha-synuclein, neuroinflammation, and oxidative stress mediated by reactive oxygen and nitrogen species (ROS/RNS). In particular, SCFAs—such as acetate, propionate, and butyrate—are involved in gut–brain communication and can modulate
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IL-4 activates ULK1/Atg9a/Rab9 in asthma, NLRP3 inflammasomes, and Golgi fragmentation by increasing autophagy flux and mitochondrial oxidative stress Redox Biol. (IF 11.4) Pub Date : 2024-02-15 Chang Xu, Yilan Song, Wanting Liu, Ruobai Liu, Qiaoyun Bai, Liangchang Li, Chongyang Wang, Guanghai Yan
During asthma, there is an intensification of pulmonary epithelial inflammation, mitochondrial oxidative stress, and Golgi apparatus fragmentation. However, the underlying mechanism remains largely unknown. Therefore, this study investigated the roles of ULK1, Atg9a, and Rab9 in epithelial inflammation, mitochondrial oxidative stress, and Golgi apparatus fragmentation. We found that ULK1 gene knockout
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Inhibition of ALK3-mediated signalling pathway protects against acetaminophen-induced liver injury Redox Biol. (IF 11.4) Pub Date : 2024-02-15 Patricia Marañón, Esther Rey, Stephania C. Isaza, Hanghang Wu, Patricia Rada, Carmen Choya-Foces, Antonio Martínez-Ruiz, María Ángeles Martín, Sonia Ramos, Carmelo García-Monzón, Francisco Javier Cubero, Ángela M. Valverde, Águeda González-Rodríguez
Acetaminophen (APAP)-induced liver injury is one of the most prevalent causes of acute liver failure (ALF). We assessed the role of the bone morphogenetic protein (BMP) type I receptors ALK2 and ALK3 in APAP-induced hepatotoxicity. The molecular mechanisms that regulate the balance between cell death and survival and the response to oxidative stress induced by APAP was assessed in cultured human hepatocyte-derived
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Metabolic activation of 2,4,6-trinitrotoluene; A case for ROS-induced cell damage Redox Biol. (IF 11.4) Pub Date : 2024-02-15 Adomako-Bonsu Amma Gyapomah, Jacobsen Jana, Maser Edmund
The explosive compound 2,4,6-trinitrotoluene (TNT) is well known as a major component of munitions. In addition to its potential carcinogenicity and mutagenicity in humans, recent reports have highlighted TNT toxicities in diverse organisms due to its occurrence in the environment. These toxic effects have been linked to the intracellular metabolism of TNT, which is generally characterised by redox
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Exploring and disentangling the production of potentially bioactive phenolic catabolites from dietary (poly)phenols, phenylalanine, tyrosine and catecholamines Redox Biol. (IF 11.4) Pub Date : 2024-02-13 Michael N. Clifford, Iziar A. Ludwig, Gema Pereira-Caro, Laila Zeraik, Gina Borges, Tahani M. Almutairi, Sara Dobani, Letizia Bresciani, Pedro Mena, Chris I.R. Gill, Alan Crozier
Following ingestion of fruits, vegetables and derived products, (poly)phenols that are not absorbed in the upper gastrointestinal tract pass to the colon, where they undergo microbiota-mediated ring fission resulting in the production of a diversity of low molecular weight phenolic catabolites, which appear in the circulatory system and are excreted in urine along with their phase II metabolites. There
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METTL17 coordinates ferroptosis and tumorigenesis by regulating mitochondrial translation in colorectal cancer Redox Biol. (IF 11.4) Pub Date : 2024-02-13 Hao Li, Kailun Yu, Huilong Hu, Xiandan Zhang, Siyu Zeng, Jiawen Li, Xiaoning Dong, Xusheng Deng, Jianhui Zhang, Yongyou Zhang
Ferroptosis, an iron-dependent lipid peroxidation-induced form of regulated cell death, shows great promise as a cancer therapy strategy. Despite the critical role of mitochondria in ferroptosis regulation, the underlying mechanisms remain elusive. This study reveals that the mitochondrial protein METTL17 governs mitochondrial function in colorectal cancer (CRC) cells through epigenetic modulation
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Iron/ROS/Itga3 mediated accelerated depletion of hippocampal neural stem cell pool contributes to cognitive impairment after hemorrhagic stroke Redox Biol. (IF 11.4) Pub Date : 2024-02-13 Xuyang Zhang, Huanhuan Li, Haomiao Wang, Qian Zhang, Xueyun Deng, Shuixian Zhang, Long Wang, Chao Guo, Fengchun Zhao, Yi Yin, Tengyuan Zhou, Jun Zhong, Hui Feng, Wei Chen, Jun Zhang, Hua Feng, Rong Hu
Hemorrhagic stroke, specifically intracerebral hemorrhage (ICH), has been implicated in the development of persistent cognitive impairment, significantly compromising the quality of life for affected individuals. Nevertheless, the precise underlying mechanism remains elusive. Here, we report for the first time that the accumulation of iron within the hippocampus, distal to the site of ICH in the striatum
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EGCG-NPs inhibition HO-1-mediated reprogram iron metabolism against ferroptosis after subarachnoid hemorrhage Redox Biol. (IF 11.4) Pub Date : 2024-02-11 Liyong Huang, Xue Wang, Yanning Zheng, Dongcen Lang, Jian Wang, Shuaiguo Yan, Ying Chen
Subarachnoid hemorrhage (SAH), a devastating disease with a high mortality rate and poor outcomes, tightly associated with the dysregulation of iron metabolism and ferroptosis. (-)-Epigallocatechin-3-gallate (EGCG) is one of major bioactive compounds of tea catechin because of its well-known iron-chelating and antioxidative activities. However, the findings of iron-induced cell injuries after SAH remain
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Neurogranin expression regulates mitochondrial function and redox balance in endothelial cells Redox Biol. (IF 11.4) Pub Date : 2024-02-11 Ashton N. Jorgensen, Nabil A. Rashdan, K.N. Shashanka Rao, Luisa F. Delgadillo, Gopi K. Kolluru, David M. Krzywanski, Christopher B. Pattillo, Christopher G. Kevil, Hyung W. Nam
Endothelial dysfunction and endothelial activation are common early events in vascular diseases and can arise from mitochondrial dysfunction. Neurogranin (Ng) is a 17kD protein well known to regulate intracellular Ca-calmodulin (CaM) complex signaling, and its dysfunction is significantly implicated in brain aging and neurodegenerative diseases. We found that Ng is also expressed in human aortic endothelial
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Regulation of immunomodulatory networks by Nrf2-activation in immune cells: Redox control and therapeutic potential in inflammatory diseases Redox Biol. (IF 11.4) Pub Date : 2024-02-10 Tarun Pant, Nnamdi Uche, Matea Juric, Jacek Zielonka, Xiaowen Bai
Inflammatory diseases present a serious health challenge due to their widespread prevalence and the severe impact on patients' lives. In the quest to alleviate the burden of these diseases, nuclear factor erythroid 2-related factor 2 (Nrf2) has emerged as a pivotal player. As a transcription factor intimately involved in cellular defense against metabolic and oxidative stress, Nrf2's role in modulating
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Propagation of a rapid cell-to-cell H2O2 signal over long distances in a monolayer of cardiomyocyte cells Redox Biol. (IF 11.4) Pub Date : 2024-02-09 Yosef Fichman, Linda Rowland, Thi Thao Nguyen, Shi-Jie Chen, Ron Mittler
Cell-to-cell communication plays a cardinal role in the biology of multicellular organisms. HO is an important cell-to-cell signaling molecule involved in the response of mammalian cells to wounding and other stimuli. We previously identified a signaling pathway that transmits wound-induced cell-to-cell HO signals within minutes over long distances, measured in centimeters, in a monolayer of cardiomyocytes
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FBXL4 protects against HFpEF through Drp1-Mediated regulation of mitochondrial dynamics and the downstream SERCA2a Redox Biol. (IF 11.4) Pub Date : 2024-02-09 Miyesaier Abudureyimu, Xuanming Luo, Lingling Jiang, Xuejuan Jin, Cuizhen Pan, Wei Yu, Junbo Ge, Yingmei Zhang, Jun Ren
Heart failure with preserved ejection fraction (HFpEF) is a devastating health issue although limited knowledge is available for its pathogenesis and therapeutics. Given the perceived involvement of mitochondrial dysfunction in HFpEF, this study was designed to examine the role of mitochondrial dynamics in the etiology of HFpEF. Adult mice were placed on a high fat diet plus -NAME in drinking water
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Endurance exercise preconditioning alleviates ferroptosis induced by doxorubicin-induced cardiotoxicity through mitochondrial superoxide-dependent AMPKα2 activation Redox Biol. (IF 11.4) Pub Date : 2024-02-08 Liang Wang, Yang Qiao, Jingzhi Yu, Qihao Wang, Xinyu Wu, Qiqi Cao, Zeyu Zhang, Zhen Feng, Huan He
Doxorubicin-induced cardiotoxicity (DIC) adversely impacts patients' long-term health and quality of life. Its underlying mechanism is complex, involving regulatory cell death mechanisms, such as ferroptosis and autophagy. Moreover, it is a challenge faced by patients undergoing cardiac rehabilitation. Endurance exercise (E-Exe) preconditioning effectively counters DIC injury, potentially through the
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DDAH1 recruits peroxiredoxin 1 and sulfiredoxin 1 to preserve its activity and regulate intracellular redox homeostasis Redox Biol. (IF 11.4) Pub Date : 2024-02-08 Juntao Yuan, Zhuoran Yu, Ping Zhang, Kai Luo, Ying Xu, Ting Lan, Min Zhang, Yingjie Chen, Zhongbing Lu
Growing evidence suggests that dimethylarginine dimethylaminohydrolase 1 (DDAH1), a crucial enzyme for the degradation of asymmetric dimethylarginine (ADMA), is closely related to oxidative stress during the development of multiple diseases. However, the underlying mechanism by which DDAH1 regulates the intracellular redox state remains unclear. In the present study, DDAH1 was shown to interact with
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BRCA1 protein dose-dependent risk for embryonic oxidative DNA damage, embryopathies and neurodevelopmental disorders with and without ethanol exposure Redox Biol. (IF 11.4) Pub Date : 2024-02-08 Danielle M. Drake, Kian Afsharian, Benjamin Or, Aaron M. Shapiro, Michelle L. Lai, Lutfiya Miller, Peter G. Wells
Although widely known as a tumor suppressor, the breast cancer 1 susceptibility protein () is also important in development, where it regulates fetal DNA repair pathways that protect against DNA damage caused by physiological and drug-enhanced levels of reactive oxygen species (). We previously showed that heterozygous () knockout () mouse embryos with a minor 28% BRCA1 deficiency developed normally
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DRD4 alleviates acute kidney injury by suppressing ISG15/NOX4 axis-associated oxidative stress Redox Biol. (IF 11.4) Pub Date : 2024-02-08 Yue Gao, Xun Lu, Guangyuan Zhang, Chunhui Liu, Si Sun, Weipu Mao, Guiya Jiang, Yu Zhou, Nieke Zhang, Shuchun Tao, Ming Chen, Shuqiu Chen, Lei Zhang
Acute kidney injury (AKI) is a life-threatening health condition associated with increasing morbidity and mortality. Despite extensive research on the mechanisms underlying AKI, effective clinical tools for prediction and treatment remain scarce. Oxidative stress and mitochondrial damage play a critical role in AKI and dopamine D4 receptor (DRD4) has been confirmed to be associated with oxidative stress
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Vascular dysfunction and arterial hypertension in experimental celiac disease are mediated by gut-derived inflammation and oxidative stress Redox Biol. (IF 11.4) Pub Date : 2024-02-08 Karin Keppeler, Aline Pesi, Simon Lange, Johanna Helmstädter, Lea Strohm, Henning Ubbens, Marin Kuntić, Ivana Kuntić, Dominika Mihaliková, Ksenija Vujačić-Mirski, Alexandra Rosenberger, Leonie Küster, Charlotte Frank, Matthias Oelze, Stefanie Finger, Agnieszka Zakrzewska, Elena Verdu, Johannes Wild, Susanne Karbach, Philip Wenzel, Philipp Wild, David Leistner, Thomas Münzel, Andreas Daiber, Detlef
We examined the cardiovascular effects of celiac disease (CeD) in a humanized mouse model, with a focus on vascular inflammation, endothelial dysfunction, and oxidative stress. NOD.DQ8 mice genetically predisposed to CeD were subjected to a diet regime and oral gavage to induce the disease (gluten group vs. control). We tested vascular function, confirmed disease indicators, and evaluated inflammation
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Constructing “smart” chelators by using an activatable prochelator strategy for the treatment of Wilson's disease Redox Biol. (IF 11.4) Pub Date : 2024-02-06 Chengcheng Wang, Roumin Wang, Lingzhou Zhao, Shasha Wang, Yan Liu, Jinhua Zhao, Yi Dong, Lingyan Liu, Peng Wei, Zhi-Ying Wu, Tao Yi
Wilson's disease (WD) is a genetic disorder that primarily leads to the pathological accumulation of copper (Cu) in the liver, causing an abnormal increase in reactive oxygen species (ROS). The prevailing clinical therapy for WD involves lifelong use of Cu chelation drugs to facilitate Cu excretion in patients. However, most available drugs exert severely side-effects due to their non-specific excretion
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Big data analytics for MerTK genomics reveals its double-edged sword functions in human diseases Redox Biol. (IF 11.4) Pub Date : 2024-02-05 Shijie Liu, Jinzi Wu, Daixuan Yang, Jianliang Xu, Hang Shi, Bingzhong Xue, Zufeng Ding
MER proto-oncogene tyrosine kinase (MerTK) is a key receptor for the clearance of apoptotic cells (efferocytosis) and plays important roles in redox-related human diseases. We will explore MerTK biology in human cells, tissues, and diseases based on big data analytics. The human RNA-seq and scRNA-seq data about 42,700 samples were from NCBI Gene Expression Omnibus and analyzed by QIAGEN Ingenuity Pathway
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New insights on neurodegeneration triggered by iron accumulation: Intersections with neutral lipid metabolism, ferroptosis, and motor impairment Redox Biol. (IF 11.4) Pub Date : 2024-02-05 Athina Maniscalchi, Oriana N. Benzi Juncos, Melisa A. Conde, Melania I. Funk, María E. Fermento, María M. Facchinetti, Alejandro C. Curino, Romina M. Uranga, Natalia P. Alza, Gabriela A. Salvador
Brain iron accumulation constitutes a pathognomonic indicator in several neurodegenerative disorders. Metal accumulation associated with dopaminergic neuronal death has been documented in Parkinson's disease. Through the use of and models, we demonstrated that lipid dysregulation manifests as a neuronal and glial response during iron overload.
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SKN-1 is indispensable for protection against Aβ-induced proteotoxicity by a selenopeptide derived from Cordyceps militaris Redox Biol. (IF 11.4) Pub Date : 2024-02-05 Mengfei Chen, Zhenjun Zhu, Shujian Wu, Aohuan Huang, Zhiqing Xie, Jie Cai, Rong Huang, Shubo Yu, Ming Liu, Jumei Zhang, Yuchung Tse, Qingping Wu, Juan Wang, Yu Ding
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FTO ameliorates doxorubicin-induced cardiotoxicity by inhibiting ferroptosis via P53–P21/Nrf2 activation in a HuR-dependent m6A manner Redox Biol. (IF 11.4) Pub Date : 2024-02-02 Yunfan Yang, Jiajun Ren, Jifeng Zhang, Henghe Shi, Junnan Wang, Youyou Yan
Doxorubicin (DOX)-induced cardiotoxicity seriously limits its clinical applicability, and no therapeutic interventions are available. Ferroptosis, an iron-dependent regulated cell death characterised by lipid peroxidation, plays a pivotal role in DOX-induced cardiotoxicity. N6-methyladenosine (m6A) methylation is the most frequent type of RNA modification and involved in DOX-induced ferroptosis, however
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Macrophage Tim-3 maintains intestinal homeostasis in DSS-induced colitis by suppressing neutrophil necroptosis Redox Biol. (IF 11.4) Pub Date : 2024-02-02 Fangfei Wang, Feng Zhou, Jianxiang Peng, Hao Chen, Jinliang Xie, Cong Liu, Huifang Xiong, Sihai Chen, Guohui Xue, Xiaojiang Zhou, Yong Xie
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Hypoxia causes trophoblast cell ferroptosis to induce miscarriage through lnc-HZ06/HIF1α-SUMO/NCOA4 axis Redox Biol. (IF 11.4) Pub Date : 2024-02-02 Peng Tian, Zhongyan Xu, Jiarong Guo, Jingsong Zhao, Weina Chen, Wenxin Huang, Manli Wang, Chenyang Mi, Ying Zhang, Yang Yang, Huidong Zhang
Defects of human trophoblast cells may induce miscarriage (abnormal early embryo loss), which is generally regulated by lncRNAs. Ferroptosis is a newly identified iron-dependent programmed cell death. Hypoxia is an important and unavoidable feature in mammalian cells. However, whether hypoxia might induce trophoblast cell ferroptosis and then induce miscarriage, as well as regulated by a lncRNA, was
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SELENOK-dependent CD36 palmitoylation regulates microglial functions and Aβ phagocytosis Redox Biol. (IF 11.4) Pub Date : 2024-02-01 Pei Ouyang, Zhiyu Cai, Jiaying Peng, Shujing Lin, Xiaochun Chen, Changbin Chen, Ziqi Feng, Lin Wang, Guoli Song, Zhonghao Zhang
Amyloid-beta (Aβ) is a key factor in the onset and progression of Alzheimer's disease (AD). Selenium (Se) compounds show promise in AD treatment. Here, we revealed that selenoprotein K (SELENOK), a selenoprotein involved in immune regulation and potentially related to AD pathology, plays a critical role in microglial immune response, migration, and phagocytosis. In vivo and in vitro studies corroborated
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The mechanism of selenium regulating the permeability of vascular endothelial cells through selenoprotein O Redox Biol. (IF 11.4) Pub Date : 2024-02-01 Jiawei Wu, Yanhe Zhang, Tianjing Liu, Jie Yang, Xiaoran Sun, Xue-jiao Gao
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Essential role of ROS – 8-Nitro-cGMP signaling in long-term memory of motor learning and cerebellar synaptic plasticity Redox Biol. (IF 11.4) Pub Date : 2024-02-01 Sho Kakizawa, Tomoko Arasaki, Ayano Yoshida, Ayami Sato, Yuka Takino, Akihito Ishigami, Takaaki Akaike, Shuichi Yanai, Shogo Endo
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A novel role for the ROS-ATM-Chk2 axis mediated metabolic and cell cycle reprogramming in the M1 macrophage polarization Redox Biol. (IF 11.4) Pub Date : 2024-02-01 Chunlu Li, Chengsi Deng, Siwei Wang, Xiang Dong, Bing Dai, Wendong Guo, Qiqiang Guo, Yanling Feng, Hongde Xu, Xiaoyu Song, Liu Cao
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NADPH-oxidases as potential pharmacological targets for thrombosis and depression comorbidity Redox Biol. (IF 11.4) Pub Date : 2024-02-01 Patrizia Amadio, Leonardo Sandrini, Marta Zarà, Silvia S. Barbieri, Alessandro Ieraci
There is a complex interrelationship between the nervous system and the cardiovascular system. Comorbidities of cardiovascular diseases (CVD) with mental disorders, and vice versa, are prevalent. Adults with mental disorders such as anxiety and depression have a higher risk of developing CVD, and people with CVD have an increased risk of being diagnosed with mental disorders.
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Hydrogen sulfide protects cardiomyocytes from doxorubicin-induced ferroptosis through the SLC7A11/GSH/GPx4 pathway by Keap1 S-sulfhydration and Nrf2 activation Redox Biol. (IF 11.4) Pub Date : 2024-01-29 Hui Zhang, Jianan Pan, Shuying Huang, Xiaonan Chen, Alex Chia Yu Chang, Changqian Wang, Junfeng Zhang, Huili Zhang
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Reactive oxygen species generation by reverse electron transfer at mitochondrial complex I under simulated early reperfusion conditions Redox Biol. (IF 11.4) Pub Date : 2024-01-27 Caio Tabata Fukushima, Ian-Shika Dancil, Hannah Clary, Nidhi Shah, Sergiy M. Nadtochiy, Paul S. Brookes
Ischemic tissues accumulate succinate, which is rapidly oxidized upon reperfusion, driving a burst of mitochondrial reactive oxygen species (ROS) generation that triggers cell death. In isolated mitochondria with succinate as the sole metabolic substrate under non-phosphorylating conditions, 90 % of ROS generation is from reverse electron transfer (RET) at the Q site of respiratory complex I (Cx-I)