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Sulfide:quinone oxidoreductase alleviates ferroptosis in acute kidney injury via ameliorating mitochondrial dysfunction of renal tubular epithelial cells Redox Biol. (IF 11.4) Pub Date : 2023-11-29 Fangfang Cai, Dangran Li, Yawen Xie, Xiaoyang Wang, Hailin Ma, Huangru Xu, Jian Cheng, Hongqin Zhuang, Zi-Chun Hua
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Identification of sulfhydryl-containing proteins and further evaluation of the selenium-tagged redox homeostasis-regulating proteins Redox Biol. (IF 11.4) Pub Date : 2023-11-27 Zhongyao Jiang, Yue Tang, Jun Lu, Chang Xu, Yaxin Niu, Guanglu Zhang, Yanmei Yang, Xiufen Cheng, Lili Tong, Zhenzhen Chen, Bo Tang
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ALS-linked SOD1 mutations impair mitochondrial-derived vesicle formation and accelerate aging Redox Biol. (IF 11.4) Pub Date : 2023-11-24 Ying Guo, Teng Guan, Qiang Yu, Nitesh Sanghai, Kashfia Shafiq, Meiyu Li, Xin Jiao, Donghui Na, Guohui Zhang, Jiming Kong
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Restoring the infected powerhouse: Mitochondrial quality control in sepsis Redox Biol. (IF 11.4) Pub Date : 2023-11-23 F.M. Lira-Chavez, L.P. Gartzke, F.E. van Beuningen, S.E. Wink, R.H. Henning, G. Krenning, H.R. Bouma
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Molecular mechanism of interleukin-17A regulating airway epithelial cell ferroptosis based on allergic asthma airway inflammation Redox Biol. (IF 11.4) Pub Date : 2023-11-22 Jingjing Song, Hui Zhang, Yu Tong, Yufei Wang, Qiangwei Xiang, Huan Dai, Cuiye Weng, Lei Wang, Junwen Fan, Yilong Shuai, Chuqiao Lai, Xiaoxiao Fang, Mingxin Chen, Jiali Bao, Weixi Zhang
Interleukin-17A (IL-17A) levels are elevated in patients with asthma. Ferroptosis has been identified as the non-apoptotic cell death type associated with asthma. Data regarding the relation of ferroptosis with asthma and the effect of IL-17A on modulating ferroptosis in asthma remain largely unclear. The present work focused on investigating the role of IL-17A in allergic asthma-related ferroptosis
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Corrigendum to “Symmetrical dimethylation of H4R3: A bridge linking DNA damage and repair upon oxidative stress” [Redox Biol. 37 (2020) 101653] Redox Biol. (IF 11.4) Pub Date : 2023-11-22 Zhuang Ma, Wentao Wang, Shiwei Wang, Xingqi Zhao, Ying Ma, Congye Wu, Zhigang Hu, Lingfeng He, Feiyan Pan, Zhigang Guo
Abstract not available
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Arbutin alleviates fatty liver by inhibiting ferroptosis via FTO/SLC7A11 pathway Redox Biol. (IF 11.4) Pub Date : 2023-11-16 Tianyu Jiang, Yao Xiao, Jinfeng Zhou, Zupeng Luo, Lin Yu, Qichao Liao, Siqi Liu, Xinyi Qi, Hao Zhang, Menglong Hou, WeiWei Miao, Batbold Batsaikhan, Turtushikh Damba, Yunxiao Liang, Yixing Li, Lei Zhou
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Organic Selenium induces ferroptosis in pancreatic cancer cells Redox Biol. (IF 11.4) Pub Date : 2023-11-20 Roberta Noè, Noemi Inglese, Patrizia Romani, Thauan Serafini, Carlotta Paoli, Beatrice Calciolari, Marco Fantuz, Agata Zamborlin, Nicoletta C. Surdo, Vittoria Spada, Martina Spacci, Sara Volta, Maria Laura Ermini, Giulietta Di Benedetto, Valentina Frusca, Claudio Santi, Konstantinos Lefkimmiatis, Sirio Dupont, Valerio Voliani, Luca Sancineto, Alessandro Carrer
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Thiosulfate sulfurtransferase deficiency promotes oxidative distress and aberrant NRF2 function in the brain Redox Biol. (IF 11.4) Pub Date : 2023-11-19 Yang Luo, Laurent Chatre, Shaden Melhem, Zayana M. Al-Dahmani, Natalie Z.M. Homer, Anneke Miedema, Leo E. Deelman, Matthew R. Groves, Martin Feelisch, Nicholas M. Morton, Amalia Dolga, Harry van Goor
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Molecular landmarks of tumor disulfidptosis across cancer types to promote disulfidptosis-target therapy Redox Biol. (IF 11.4) Pub Date : 2023-11-19 Deze Zhao, Yu Meng, Yating Dian, Qian Zhou, Yuming Sun, Jiayuan Le, Furong Zeng, Xiang Chen, Yi He, Guangtong Deng
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Oxidative stress in the eye and its role in the pathophysiology of ocular diseases Redox Biol. (IF 11.4) Pub Date : 2023-11-18 Elsa Wilma Böhm, Francesco Buonfiglio, Anna Maria Voigt, Philipp Bachmann, Tarek Safi, Norbert Pfeiffer, Adrian Gericke
Oxidative stress occurs through an imbalance between the generation of reactive oxygen species (ROS) and the antioxidant defense mechanisms of cells. The eye is particularly exposed to oxidative stress because of its permanent exposure to light and due to several structures having high metabolic activities. The anterior part of the eye is highly exposed to ultraviolet (UV) radiation and possesses a
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Estradiol-mediated small GTP-binding protein GDP dissociation stimulator induction contributes to sex differences in resilience to ferroptosis in takotsubo syndrome Redox Biol. (IF 11.4) Pub Date : 2023-11-16 Ti Wang, Ting Xiong, Yuxue Yang, Xiwei Chen, Ziwei Ma, Bangyun Zuo, Dong Ning, Beibei Zhou, Ruilong Song, Xuesong Liu, Daxin Wang
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Oxygen metabolism abnormality and Alzheimer's disease: An update Redox Biol. (IF 11.4) Pub Date : 2023-11-08 Guangdong Liu, Cui Yang, Xin Wang, Xi Chen, Yanjiang Wang, Weidong Le
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Corrigendum to “Low density lipoprotein receptor related protein 6 (LRP6) protects heart against oxidative stress by the crosstalk of HSF1 and GSK3β” [Redox Biol. 37 (2020) 101699] Redox Biol. (IF 11.4) Pub Date : 2023-11-10 Ying Wang, Zhidan Chen, Yang Li, Leilei Ma, Yan Zou, Xiang Wang, Chao Yin, Le Pan, Yi Shen, Jianguo Jia, Jie Yuan, Guoping Zhang, Chunjie Yang, Junbo Ge, Yunzeng Zou, Hui Gong
Abstract not available
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Corrigendum to “Mulberrin confers protection against hepatic fibrosis by Trim31/Nrf2 signaling” [Redox Biol. 51 (2022) 102274] Redox Biol. (IF 11.4) Pub Date : 2023-11-10 Chenxu Ge, Jun Tan, Deshuai Lou, Liancai Zhu, Zixuan Zhong, Xianling Dai, Yan Sun, Qin Kuang, Junjie Zhao, Longyan Wang, Jin Liu, Bochu Wang, Minxuan Xu
Abstract not available
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CXCR4-BTK axis mediate pyroptosis and lipid peroxidation in early brain injury after subarachnoid hemorrhage via NLRP3 inflammasome and NF-κB pathway Redox Biol. (IF 11.4) Pub Date : 2023-11-10 Chengli Liu, Kun Yao, Qi Tian, Yujia Guo, Guijun Wang, Peibang He, Jianfeng Wang, Jian Wang, Zhan Zhang, Mingchang Li
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A novel CPT1A covalent inhibitor modulates fatty acid oxidation and CPT1A-VDAC1 axis with therapeutic potential for colorectal cancer Redox Biol. (IF 11.4) Pub Date : 2023-11-10 Anni Hu, Hang Wang, Qianqian Xu, Yuqi Pan, Zeyu Jiang, Sheng Li, Yi Qu, Yili Hu, Hao Wu, Xinzhi Wang
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RelB-activated GPX4 inhibits ferroptosis and confers tamoxifen resistance in breast cancer Redox Biol. (IF 11.4) Pub Date : 2023-11-04 Zhi Xu, Xiumei Wang, Wenbo Sun, Fan Xu, Hengyuan Kou, Weizi Hu, Yanyan Zhang, Qin Jiang, Jinhai Tang, Yong Xu
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A role for the cystathionine-β-synthase /H2S axis in astrocyte dysfunction in the aging brain Redox Biol. (IF 11.4) Pub Date : 2023-11-06 Anindya Dey, Pijush Kanti Pramanik, Shailendra Kumar Dhar Dwivedi, Fiifi Neizer-Ashun, Tamas Kiss, Abhrajit Ganguly, Heather Rice, Priyabrata Mukherjee, Chao Xu, Mohiuddin Ahmad, Anna Csiszar, Resham Bhattacharya
Astrocytic dysfunction is central to age-related neurodegenerative diseases. However, the mechanisms leading to astrocytic dysfunction are not well understood. We identify that among the diverse cellular constituents of the brain, murine and human astrocytes are enriched in the expression of CBS. Depleting CBS in astrocytes causes mitochondrial dysfunction, increases the production of reactive oxygen
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MIOX inhibits autophagy to regulate the ROS -driven inhibition of STAT3/c-Myc-mediated epithelial-mesenchymal transition in clear cell renal cell carcinoma Redox Biol. (IF 11.4) Pub Date : 2023-11-07 Longxiyu Meng, Jie Gao, Wenjing Mo, Baojun Wang, Hongwei Shen, Wenmin Cao, Meng Ding, Wenli Diao, Wei Chen, Qing Zhang, Jiaxin Shu, Huiqi Dai, Hongqian Guo
The specific mechanism of clear cell renal cell carcinoma (ccRCC) progression, a pathological type that accounts for the highest proportion of RCC, remains unclear. In this study, bioinformatics analysis of scRNA-seq dataset in ccRCC revealed that MIOX was a gene specifically down-regulated in tumor epithelial cells of ccRCC. Analysis of the TCGA database further validated the association between decreased
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The effect of iron therapy on oxidative stress and intestinal microbiota in inflammatory bowel diseases: A review on the conundrum Redox Biol. (IF 11.4) Pub Date : 2023-10-30 R. Loveikyte, A.R. Bourgonje, H. van Goor, G. Dijkstra, A.E. van der Meulen – de Jong
One in five patients with Inflammatory Bowel Disease (IBD) suffers from anemia, most frequently caused by iron deficiency. Anemia and iron deficiency are associated with worse disease outcomes, reduced quality of life, decreased economic participation, and increased healthcare costs. International guidelines and consensus-based recommendations have emphasized the importance of treating anemia and iron
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Hypoxia increases persulfide and polysulfide formation by AMP kinase dependent cystathionine gamma lyase phosphorylation Redox Biol. (IF 11.4) Pub Date : 2023-10-30 Shafiul Alam, Sibile Pardue, Xinggui Shen, John D. Glawe, Takashi Yagi, Mohammad Alfrad Nobel Bhuiyan, Rakesh P. Patel, Paari S. Dominic, Chiranjiv S. Virk, Md Shenuarin Bhuiyan, A. Wayne Orr, Chad Petit, Gopi K. Kolluru, Christopher G. Kevil
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Enhanced fatty acid oxidation through metformin and baicalin as therapy for COVID-19 and associated inflammatory states in lung and kidney Redox Biol. (IF 11.4) Pub Date : 2023-11-03 Verónica Miguel, Carlos Rey-Serra, Jessica Tituaña, Belén Sirera, Elena Alcalde-Estévez, J. Ignacio Herrero, Irene Ranz, Laura Fernández, Carolina Castillo, Lucía Sevilla, James Nagai, Katharina C. Reimer, Jitske Jansen, Rafael Kramann, Ivan G. Costa, Ana Castro, David Sancho, José Miguel Rodríguez González-Moro, Santiago Lamas
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NRF2 is essential for adaptative browning of white adipocytes Redox Biol. (IF 11.4) Pub Date : 2023-10-31 Marco Bauzá-Thorbrügge, Eduard Peris, Shabnam Zamani, Peter Micallef, Alexandra Paul, Stefano Bartesaghi, Anna Benrick, Ingrid Wernstedt Asterholm
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Intestinal polyphenol antioxidant activity involves redox signaling mechanisms facilitated by aquaporin activity Redox Biol. (IF 11.4) Pub Date : 2023-10-28 Kaiwen Mu, David D. Kitts
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Nogo-B mediates endothelial oxidative stress and inflammation to promote coronary atherosclerosis in pressure-overloaded mouse hearts Redox Biol. (IF 11.4) Pub Date : 2023-10-21 Yu Zhang, Jing-Jing Li, Rui Xu, Xin-Pei Wang, Xin-Yi Zhao, Yuan Fang, Yu-Peng Chen, Shan Ma, Xiao-Hui Di, Wei Wu, Gang She, Zheng-Da Pang, Yi-Dong Wang, Xing Zhang, Wenjun Xie, Xiu-Ling Deng, Xiao-Jun Du, Yi Zhang
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Single-cell RNA sequencing of intestinal crypts reveals vital events in damage repair and the double-edged sword effect of the Wnt3/β-catenin pathway in irradiated mice Redox Biol. (IF 11.4) Pub Date : 2023-10-25 Tong Yuan, Junling Zhang, Yue Zhao, Yuying Guo, Saijun Fan
In this study, we executed single-cell RNA sequencing of intestinal crypts. We analyzed the differentially expressed genes (DEGs) at different time points (the first, third, and fifth days) after 13 Gy and 15 Gy abdominal body radiation (ABR) exposure and then executed gene ontology (GO) enrichment analysis, RNA velocity analysis, cell communication analysis, and ligand‒receptor interaction analysis
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Adaptive responses of neuronal cells to chronic endoplasmic reticulum (ER) stress Redox Biol. (IF 11.4) Pub Date : 2023-10-20 Thu Nguyen Minh Pham, Natarajan Perumal, Caroline Manicam, Marion Basoglu, Stefan Eimer, Dominik C. Fuhrmann, Claus U. Pietrzik, Albrecht M. Clement, Hagen Körschgen, Jana Schepers, Christian Behl
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Fatty acid nitroalkenes – Multi-target agents for the treatment of sickle cell disease Redox Biol. (IF 11.4) Pub Date : 2023-10-24 Fabliha A. Chowdhury, Nicole Colussi, Malini Sharma, Katherine C. Wood, Julia Z. Xu, Bruce A. Freeman, Francisco J. Schopfer, Adam C. Straub
Sickle cell disease (SCD) is a hereditary hematological disease with high morbidity and mortality rates worldwide. Despite being monogenic, SCD patients display a plethora of disease-associated complications including anemia, oxidative stress, sterile inflammation, vaso-occlusive crisis-related pain, and vasculopathy, all of which contribute to multiorgan dysfunction and failure. Over the past decade
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Non-steroidal mineralocorticoid receptor antagonist finerenone ameliorates mitochondrial dysfunction via PI3K/Akt/eNOS signaling pathway in diabetic tubulopathy Redox Biol. (IF 11.4) Pub Date : 2023-10-24 Lan Yao, Xianhui Liang, Yamin Liu, Bingyu Li, Mei Hong, Xin Wang, Bohan Chen, Zhangsuo Liu, Pei Wang
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Cardiomyocyte NOX4 regulates resident macrophage-mediated inflammation and diastolic dysfunction in stress cardiomyopathy Redox Biol. (IF 11.4) Pub Date : 2023-10-19 Aleksandr E. Vendrov, Han Xiao, Andrey Lozhkin, Takayuki Hayami, Guomin Hu, Matthew J. Brody, Junichi Sadoshima, You-Yi Zhang, Marschall S. Runge, Nageswara R. Madamanchi
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50 shades of oxidative stress: A state-specific cysteine redox pattern hypothesis Redox Biol. (IF 11.4) Pub Date : 2023-10-17 James N. Cobley
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Corrigendum to “Natural mutations of human XDH promote the nitrite (NO2−)-reductase capacity of xanthine oxidoreductase: A novel mechanism to promote redox health?” [Redox Biol. 4 (67) (2023) 102864] Redox Biol. (IF 11.4) Pub Date : 2023-10-21 G. Massimo, R.S. Khambata, T. Chapman, K. Birchall, C. Raimondi, A. Shabbir, Nicki Dyson, K. Rathod, C. Borghi, A. Ahluwalia
Abstract not available
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The SGK3-Catalase antioxidant signaling axis drives cervical cancer growth and therapy resistance Redox Biol. (IF 11.4) Pub Date : 2023-10-16 Min Wang, Jiannan Liu, Xingming Liao, Yasong Yi, Yijue Xue, Ling Yang, Hailing Cheng, Pixu Liu
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A novel combination therapy with Cabozantinib and Honokiol effectively inhibits c-Met-Nrf2-induced renal tumor growth through increased oxidative stress Redox Biol. (IF 11.4) Pub Date : 2023-10-21 Laxminarayan Rawat, Murugabaskar Balan, Yuzuru Sasamoto, Akash Sabarwal, Soumitro Pal
Receptor tyrosine kinase (RTK), c-Met, is overexpressed and hyper active in renal cell carcinoma (RCC). Most of the therapeutic agents mediate cancer cell death through increased oxidative stress. Induction of c-Met in renal cancer cells promotes the activation of redox-sensitive transcription factor Nrf2 and cytoprotective heme oxygenase-1 (HO-1), which can mediate therapeutic resistance against oxidative
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A critical role for staphylococcal nitric oxide synthase in controlling flavohemoglobin toxicity Redox Biol. (IF 11.4) Pub Date : 2023-10-16 Ryan M. Singh, Sujata S. Chaudhari, Sasmita Panda, Elizabeth H. Hutfless, Cortney E. Heim, Dhananjay Shinde, Abdulelah A. Alqarzaee, Margaret Sladek, Vineet Kumar, Matthew C. Zimmerman, Paul D. Fey, Tammy Kielian, Vinai C. Thomas
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HDAC3 aberration-incurred GPX4 suppression drives renal ferroptosis and AKI-CKD progression Redox Biol. (IF 11.4) Pub Date : 2023-10-20 Lijun Zhang, Fang Chen, Jian Dong, Rong Wang, Guangyu Bi, Daoliang Xu, Yingwei Zhang, Yijun Deng, Wenjun Lin, Zhongzhou Yang, Wangsen Cao
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Oxidative/nitrosative stress increased the risk of recurrent pregnancy loss–Taiwan Recurrent Pregnancy Loss and Environmental Study (TREPLES) Redox Biol. (IF 11.4) Pub Date : 2023-10-19 Yu-Jung Lin, Wei-Hsiang Chang, Pao-Lin Kuo, Hsin-Chang Chen, Wan-Ting Chang, Po-Chin Huang
Objective Oxidative stress biomarkers (OSBs) may be strongly associated with disease progression and recurrent pregnancy loss (RPL). However, the research on associations of most OSBs (e.g., 8-nitroguanine [8-NO2Gua] and 4-hydroxy-2-nonenal-mercapturic acid [HNE-MA]) with RPL is limited. Therefore, we aimed to investigate the effect of OSBs exposure on RPL risk by performing a case-control study. Material
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Defective function of α-ketoglutarate dehydrogenase exacerbates mitochondrial ATP deficits during complex I deficiency Redox Biol. (IF 11.4) Pub Date : 2023-10-17 Gerardo G. Piroli, Allison M. Manuel, Richard S. McCain, Holland H. Smith, Oliver Ozohanics, Sara Mellid, J. Hunter Cox, William E. Cotham, Michael D. Walla, Alberto Cascón, Attila Ambrus, Norma Frizzell
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Dimethyl fumarate ameliorates erectile dysfunction in bilateral cavernous nerve injury rats by inhibiting oxidative stress and NLRP3 inflammasome-mediated pyroptosis of nerve via activation of Nrf2/HO-1 signaling pathway Redox Biol. (IF 11.4) Pub Date : 2023-10-18 Guoda Song, Jiaxin Wang, Jihong Liu, Yajun Ruan
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Modulation of recovery from neonatal hyperoxic lung injury by sex as a biological variable Redox Biol. (IF 11.4) Pub Date : 2023-10-18 Abiud Cantu, Manuel Cantu Gutierrez, Xiaoyu Dong, Connor Leek, Montserrat Anguera, Krithika Lingappan
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(Poly)phenols and the regulation of NADPH oxidases Redox Biol. (IF 11.4) Pub Date : 2023-10-17 Cesar G. Fraga, Patricia I. Oteiza, Ezequiel J. Hid, Monica Galleano
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YTHDF1 mitigates acute kidney injury via safeguarding m6A-methylated mRNAs in stress granules of renal tubules Redox Biol. (IF 11.4) Pub Date : 2023-10-13 Wenwen Yang, Mingchao Zhang, Jiacheng Li, Shuang Qu, Fenglian Zhou, Minghui Liu, Limin Li, Zhihong Liu, Ke Zen
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Mitochondrial complex I ROS production and redox signaling in hypoxia Redox Biol. (IF 11.4) Pub Date : 2023-10-16 Chidozie N. Okoye, Shon A. Koren, Andrew P. Wojtovich
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Uncovering SOD3 and GPX4 as new targets of Benzo[α]pyrene-induced hepatotoxicity through Metabolomics and Chemical Proteomics Redox Biol. (IF 11.4) Pub Date : 2023-10-11 Yanwei Wang, Jiahui Zhao, Yipeng Xu, Cimin Tao, Jie Tong, Yingjie Luo, Yong Chen, Xuesong Liu, Tengfei Xu
Benzo[α]pyrene (Bap) is recognized as a ubiquitous environmental pollutant among the polycyclic aromatic hydrocarbons (PAHs) class. Previous studies have shown that the hepatotoxicity of Bap is mainly caused by its metabolites, although it remains unclear whether Bap itself induces such damage. This study integrated metabolomics and chemical proteomics approaches to comprehensively identify the potential
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Immunoediting of KEAP1-NRF2 mutant tumours is required to circumvent NRF2-mediated immune surveillance Redox Biol. (IF 11.4) Pub Date : 2023-10-10 Liam Baird, Masayuki Yamamoto
In human cancer, activating mutations in the KEAP1-NRF2 pathway are frequently observed, and positively selected for, as they confer the cytoprotective functions of the transcription factor NRF2 on the cancer cells. This results in the development of aggressive tumours which are resistant to treatment with chemotherapeutic compounds. Recent clinical developments have also revealed that NRF2-activated
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Nitric oxide inhibits FTO demethylase activity to regulate N6-methyladenosine mRNA methylation Redox Biol. (IF 11.4) Pub Date : 2023-10-14 Hannah Petraitis Kuschman, Marianne B. Palczewski, Brian Hoffman, Mary Menhart, Xiaowei Wang, Sharon Glynn, Abul B.M.M.K. Islam, Elizaveta V. Benevolenskaya, Douglas D. Thomas
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Corrigendum to “Cholesterol confers ferroptosis resistance onto myeloid-biased hematopoietic stem cells and prevents irradiation-induced myelosuppression” [Redox Biol. 62 (2023) 102661] Redox Biol. (IF 11.4) Pub Date : 2023-10-13 Chaonan Liu, Weinian Liao, Jun Chen, Kuan Yu, Yiding Wu, Shuzhen Zhang, Mo Chen, Fang Chen, Song Wang, Tianmin Cheng, Junping Wang, Changhong Du
Abstract not available
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Reactive oxygen species drive foraging decisions in Caenorhabditis elegans Redox Biol. (IF 11.4) Pub Date : 2023-10-13 Andrew P. Bischer, Timothy M. Baran, Andrew P. Wojtovich
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Clozapine suppresses NADPH oxidase activation, counteracts cytosolic H2O2, and triggers early onset mitochondrial dysfunction during adipogenesis of human liposarcoma SW872 cells Redox Biol. (IF 11.4) Pub Date : 2023-10-12 Giulia Blandino, Mara Fiorani, Barbara Canonico, Rita De Matteis, Andrea Guidarelli, Mariele Montanari, Gloria Buffi, Lucia Coppo, Elias S.J. Arnér, Orazio Cantoni
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Fullerol rescues the light-induced retinal damage by modulating Müller glia cell fate Redox Biol. (IF 11.4) Pub Date : 2023-10-05 Zhe Cha, Zhiyuan Yin, Luodan A, Lingling Ge, Junling Yang, Xiaona Huang, Hui Gao, Xia Chen, Zhou Feng, Lingyue Mo, Juncai He, Shuang Zhu, Maoru Zhao, Zui Tao, Zhanjun Gu, Haiwei Xu
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Iridium metal complex targeting oxidation resistance 1 protein attenuates spinal cord injury by inhibiting oxidative stress-associated reactive oxygen species Redox Biol. (IF 11.4) Pub Date : 2023-10-10 Cheng Peng, Jianxian Luo, Ke Wang, Jianping Li, Yanming Ma, Juanjuan Li, Hua Yang, Tianjun Chen, Guowei Zhang, Xin Ji, Yuhui Liao, Hongsheng Lin, Zhisheng Ji
Oxidative stress is a key factor leading to profound neurological deficits following spinal cord injury (SCI). In this study, we present the development and potential application of an iridium (iii) complex, (CpxbiPh) Ir (N^N) Cl, where CpxbiPh represents 1-biphenyl-2,3,4,5-tetramethyl cyclopentadienyl, and N^N denotes 2-(3-(4-nitrophenyl)-1H-1,2,4-triazol-5-yl) pyridine chelating agents, to address
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Arginase2 mediates contrast-induced acute kidney injury via facilitating nitrosative stress in tubular cells Redox Biol. (IF 11.4) Pub Date : 2023-10-10 Ling-yun Zhou, Kun Liu, Wen-jun Yin, Yue-liang Xie, Jiang-lin Wang, Shan-ru Zuo, Zhi-yao Tang, Yi-feng Wu, Xiao-cong Zuo
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Changes to insulin sensitivity in glucose clearance systems and redox following dietary supplementation with a novel cysteine-rich protein: A pilot randomized controlled trial in humans with type-2 diabetes Redox Biol. (IF 11.4) Pub Date : 2023-10-05 W.M. Peeters, M. Gram, G.J. Dias, M.C.M. Vissers, M.B. Hampton, N. Dickerhof, A.E. Bekhit, M.J. Black, J. Oxbøll, S. Bayer, M. Dickens, K. Vitzel, P.W. Sheard, K.M. Danielson, L.D. Hodges, J.C. Brønd, J. Bond, B.G. Perry, L. Stoner, J. Cornwall, D.S. Rowlands
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Glutathione and peroxisome redox homeostasis Redox Biol. (IF 11.4) Pub Date : 2023-10-04 Maria J. Ferreira, Tony A. Rodrigues, Ana G. Pedrosa, Ana R. Silva, Beatriz G. Vilarinho, Tânia Francisco, Jorge E. Azevedo
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Oxalate disrupts monocyte and macrophage cellular function via Interleukin-10 and mitochondrial reactive oxygen species (ROS) signaling Redox Biol. (IF 11.4) Pub Date : 2023-10-04 Parveen Kumar, Emma Laurence, David K. Crossman, Dean G. Assimos, Michael P. Murphy, Tanecia Mitchell
Oxalate is a small compound found in certain plant-derived foods and is a major component of calcium oxalate (CaOx) kidney stones. Individuals that consume oxalate enriched meals have an increased risk of forming urinary crystals, which are precursors to CaOx kidney stones. We previously reported that a single dietary oxalate load induces nanocrystalluria and reduces monocyte cellular bioenergetics
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Neutrophil extracellular traps drive intestinal microvascular endothelial ferroptosis by impairing Fundc1-dependent mitophagy Redox Biol. (IF 11.4) Pub Date : 2023-10-04 Chengnan Chu, Xinyu Wang, Chao Yang, Fang Chen, Lin Shi, Weiqi Xu, Kai Wang, Baochen Liu, Chenyang Wang, Dongping Sun, Weiwei Ding
Microvascular endothelial damage caused by intestinal ischemia‒reperfusion (II/R) is a primary catalyst for microcirculation dysfunction and enterogenous infection. Previous studies have mainly focused on how neutrophil extracellular traps (NETs) and ferroptosis cause intestinal epithelial injury, and little attention has been given to how NETs, mainly from circulatory neutrophils, affect intestinal
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DNA dioxygenases TET2 deficiency promotes cigarette smoke induced chronic obstructive pulmonary disease by inducing ferroptosis of lung epithelial cell Redox Biol. (IF 11.4) Pub Date : 2023-10-04 Zihang Zeng, Tiao Li, Xiangming Liu, Yiming Ma, Lijuan Luo, ZuLi Wang, Zhiqi Zhao, Herui Li, Xue He, Huihui Zeng, Yongguang Tao, Yan Chen
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Cancer-associated fibroblasts impair the cytotoxic function of NK cells in gastric cancer by inducing ferroptosis via iron regulation Redox Biol. (IF 11.4) Pub Date : 2023-10-06 Lizhong Yao, Junyi Hou, Xiongyan Wu, Yifan Lu, Zhijian Jin, Zhenjia Yu, Beiqin Yu, Jianfang Li, Zhongyin Yang, Chen Li, Min Yan, Zhenggang Zhu, Bingya Liu, Chao Yan, Liping Su
As the predominant immunosuppressive component within the tumor microenvironment (TME), cancer-associated fibroblasts (CAFs) inhibit Natural Killer cell (NK cell) activity to promote tumor progression and immune escape; however, the mechanisms of cross-talk between CAFs and NK cells in gastric cancer (GC) remain poorly understood. In this study, we demonstrate that NK cell levels are inversely correlated
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Health position paper and redox perspectives on reactive oxygen species as signals and targets of cardioprotection Redox Biol. (IF 11.4) Pub Date : 2023-10-06 Gerd Heusch, Ioanna Andreadou, Robert Bell, Edoardo Bertero, Hans-Erik Botker, Sean M. Davidson, James Downey, Philip Eaton, Peter Ferdinandy, Bernard J. Gersh, Mauro Giacca, Derek J. Hausenloy, Borja Ibanez, Thomas Krieg, Christoph Maack, Rainer Schulz, Frank Sellke, Ajay M. Shah, Holger Thiele, Derek M. Yellon, Fabio Di Lisa