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Unravelling and reconstructing the biosynthetic pathway of bergenin Nat. Commun. (IF 16.6) Pub Date : 2024-04-26 Ruiqi Yan, Binghan Xie, Kebo Xie, Qi Liu, Songyang Sui, Shuqi Wang, Dawei Chen, Jimei Liu, Ridao Chen, Jungui Dai, Lin Yang
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Identification of triacylglycerol remodeling mechanism to synthesize unusual fatty acid containing oils Nat. Commun. (IF 16.6) Pub Date : 2024-04-26 Prasad Parchuri, Sajina Bhandari, Abdul Azeez, Grace Chen, Kumiko Johnson, Jay Shockey, Andrei Smertenko, Philip D. Bates
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Diphthamide deficiency promotes association of eEF2 with p53 to induce p21 expression and neural crest defects Nat. Commun. (IF 16.6) Pub Date : 2024-04-26 Yu Shi, Daochao Huang, Cui Song, Ruixue Cao, Zhao Wang, Dan Wang, Li Zhao, Xiaolu Xu, Congyu Lu, Feng Xiong, Haowen Zhao, Shuxiang Li, Quansheng Zhou, Shuyue Luo, Dongjie Hu, Yun Zhang, Cui Wang, Yiping Shen, Weiting Su, Yili Wu, Karl Schmitz, Shuo Wei, Weihong Song
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Oxygen enhances antiviral innate immunity through maintenance of EGLN1-catalyzed proline hydroxylation of IRF3 Nat. Commun. (IF 16.6) Pub Date : 2024-04-26 Xing Liu, Jinhua Tang, Zixuan Wang, Chunchun Zhu, Hongyan Deng, Xueyi Sun, Guangqing Yu, Fangjing Rong, Xiaoyun Chen, Qian Liao, Shuke Jia, Wen Liu, Huangyuan Zha, Sijia Fan, Xiaolian Cai, Jian-Fang Gui, Wuhan Xiao
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Targeted small molecule inhibitors blocking the cytolytic effects of pneumolysin and homologous toxins Nat. Commun. (IF 16.6) Pub Date : 2024-04-26 Umer Bin Abdul Aziz, Ali Saoud, Marcel Bermudez, Maren Mieth, Amira Atef, Thomas Rudolf, Christoph Arkona, Timo Trenkner, Christoph Böttcher, Kai Ludwig, Angelique Hoelzemer, Andreas C. Hocke, Gerhard Wolber, Jörg Rademann
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Structural insights into the functional mechanism of the ubiquitin ligase E6AP Nat. Commun. (IF 16.6) Pub Date : 2024-04-26 Zhen Wang, Fengying Fan, Zhihai Li, Fei Ye, Qingxia Wang, Rongchao Gao, Jiaxuan Qiu, Yixin Lv, Min Lin, Wenwen Xu, Cheng Luo, Xuekui Yu
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High-entropy engineering of the crystal and electronic structures in a Dirac material Nat. Commun. (IF 16.6) Pub Date : 2024-04-26 Antu Laha, Suguru Yoshida, Francisco Marques dos Santos Vieira, Hemian Yi, Seng Huat Lee, Sai Venkata Gayathri Ayyagari, Yingdong Guan, Lujin Min, Jose Gonzalez Jimenez, Leixin Miao, David Graf, Saugata Sarker, Weiwei Xie, Nasim Alem, Venkatraman Gopalan, Cui-Zu Chang, Ismaila Dabo, Zhiqiang Mao
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Mucosal prime-boost immunization with live murine pneumonia virus-vectored SARS-CoV-2 vaccine is protective in macaques Nat. Commun. (IF 16.6) Pub Date : 2024-04-26 Jaclyn A. Kaiser, Christine E. Nelson, Xueqiao Liu, Hong-Su Park, Yumiko Matsuoka, Cindy Luongo, Celia Santos, Laura R. H. Ahlers, Richard Herbert, Ian N. Moore, Temeri Wilder-Kofie, Rashida Moore, April Walker, Lijuan Yang, Shirin Munir, I-Ting Teng, Peter D. Kwong, Kennichi Dowdell, Hanh Nguyen, JungHyun Kim, Jeffrey I. Cohen, Reed F. Johnson, Nicole L. Garza, Laura E. Via, Daniel L. Barber, Ursula
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Visualizing a single wavefront dislocation induced by orbital angular momentum in graphene Nat. Commun. (IF 16.6) Pub Date : 2024-04-26 Yi-Wen Liu, Yu-Chen Zhuang, Ya-Ning Ren, Chao Yan, Xiao-Feng Zhou, Qian Yang, Qing-Feng Sun, Lin He
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The airborne transmission of viruses causes tight transmission bottlenecks Nat. Commun. (IF 16.6) Pub Date : 2024-04-26 Patrick Sinclair, Lei Zhao, Clive B. Beggs, Christopher J. R. Illingworth
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Biocompatible aggregation-induced emission active polyphosphate-manganese nanosheets with glutamine synthetase-like activity in excitotoxic nerve cells Nat. Commun. (IF 16.6) Pub Date : 2024-04-26 Jing Wang, Xinyang Zhao, Yucheng Tao, Xiuxiu Wang, Li Yan, Kuang Yu, Yi Hsu, Yuncong Chen, Jing Zhao, Yong Huang, Wei Wei
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Understanding X-ray absorption in liquid water using triple excitations in multilevel coupled cluster theory Nat. Commun. (IF 16.6) Pub Date : 2024-04-26 Sarai Dery Folkestad, Alexander C. Paul, Regina Paul (Née Matveeva), Sonia Coriani, Michael Odelius, Marcella Iannuzzi, Henrik Koch
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CAR affinity modulates the sensitivity of CAR-T cells to PD-1/PD-L1-mediated inhibition Nat. Commun. (IF 16.6) Pub Date : 2024-04-26 Irene Andreu-Saumell, Alba Rodriguez-Garcia, Vanessa Mühlgrabner, Marta Gimenez-Alejandre, Berta Marzal, Joan Castellsagué, Fara Brasó-Maristany, Hugo Calderon, Laura Angelats, Salut Colell, Mara Nuding, Marta Soria-Castellano, Paula Barbao, Aleix Prat, Alvaro Urbano-Ispizua, Johannes B. Huppa, Sonia Guedan
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Predicting maximum strain hardening factor in elongational flow of branched pom-pom polymers from polymer architecture Nat. Commun. (IF 16.6) Pub Date : 2024-04-26 Max G. Schußmann, Manfred Wilhelm, Valerian Hirschberg
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Disordered clock protein interactions and charge blocks turn an hourglass into a persistent circadian oscillator Nat. Commun. (IF 16.6) Pub Date : 2024-04-25 Meaghan S. Jankowski, Daniel Griffith, Divya G. Shastry, Jacqueline F. Pelham, Garrett M. Ginell, Joshua Thomas, Pankaj Karande, Alex S. Holehouse, Jennifer M. Hurley
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Local incomplete combustion emissions define the PM2.5 oxidative potential in Northern India Nat. Commun. (IF 16.6) Pub Date : 2024-04-25 Deepika Bhattu, Sachchida Nand Tripathi, Himadri Sekhar Bhowmik, Vaios Moschos, Chuan Ping Lee, Martin Rauber, Gary Salazar, Gülcin Abbaszade, Tianqu Cui, Jay G. Slowik, Pawan Vats, Suneeti Mishra, Vipul Lalchandani, Rangu Satish, Pragati Rai, Roberto Casotto, Anna Tobler, Varun Kumar, Yufang Hao, Lu Qi, Peeyush Khare, Manousos Ioannis Manousakas, Qiyuan Wang, Yuemei Han, Jie Tian, Sophie Darfeuil
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Control of polymers’ amorphous-crystalline transition enables miniaturization and multifunctional integration for hydrogel bioelectronics Nat. Commun. (IF 16.6) Pub Date : 2024-04-25 Sizhe Huang, Xinyue Liu, Shaoting Lin, Christopher Glynn, Kayla Felix, Atharva Sahasrabudhe, Collin Maley, Jingyi Xu, Weixuan Chen, Eunji Hong, Alfred J. Crosby, Qianbin Wang, Siyuan Rao
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Purines enrich root-associated Pseudomonas and improve wild soybean growth under salt stress Nat. Commun. (IF 16.6) Pub Date : 2024-04-25 Yanfen Zheng, Xuwen Cao, Yanan Zhou, Siqi Ma, Youqiang Wang, Zhe Li, Donglin Zhao, Yanzhe Yang, Han Zhang, Chen Meng, Zhihong Xie, Xiaona Sui, Kangwen Xu, Yiqiang Li, Cheng-Sheng Zhang
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Dietary L-Glu sensing by enteroendocrine cells adjusts food intake via modulating gut PYY/NPF secretion Nat. Commun. (IF 16.6) Pub Date : 2024-04-25 Junjun Gao, Song Zhang, Pan Deng, Zhigang Wu, Bruno Lemaitre, Zongzhao Zhai, Zheng Guo
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Vegetation dieback in the Mississippi River Delta triggered by acute drought and chronic relative sea-level rise Nat. Commun. (IF 16.6) Pub Date : 2024-04-25 Tracy Elsey-Quirk, Austin Lynn, Michael Derek Jacobs, Rodrigo Diaz, James T. Cronin, Lixia Wang, Haosheng Huang, Dubravko Justic
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Dynamic corticothalamic modulation of the somatosensory thalamocortical circuit during wakefulness Nat. Commun. (IF 16.6) Pub Date : 2024-04-25 Elaida D. Dimwamwa, Aurélie Pala, Vivek Chundru, Nathaniel C. Wright, Garrett B. Stanley
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Photobody formation spatially segregates two opposing phytochrome B signaling actions of PIF5 degradation and stabilization Nat. Commun. (IF 16.6) Pub Date : 2024-04-25 Ruth Jean Ae Kim, De Fan, Jiangman He, Keunhwa Kim, Juan Du, Meng Chen
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BIN1 knockdown rescues systolic dysfunction in aging male mouse hearts Nat. Commun. (IF 16.6) Pub Date : 2024-04-25 Maartje Westhoff, Silvia G. del Villar, Taylor L. Voelker, Phung N. Thai, Heather C. Spooner, Alexandre D. Costa, Padmini Sirish, Nipavan Chiamvimonvat, Eamonn J. Dickson, Rose E. Dixon
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Cortex-wide transcranial localization microscopy with fluorescently labeled red blood cells Nat. Commun. (IF 16.6) Pub Date : 2024-04-25 Quanyu Zhou, Chaim Glück, Lin Tang, Lukas Glandorf, Jeanne Droux, Mohamad El Amki, Susanne Wegener, Bruno Weber, Daniel Razansky, Zhenyue Chen
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Warming drives dissolved organic carbon export from pristine alpine soils Nat. Commun. (IF 16.6) Pub Date : 2024-04-25 Andrew R. Pearson, Bethany R. S. Fox, John C. Hellstrom, Marcus J. Vandergoes, Sebastian F. M. Breitenbach, Russell N Drysdale, Sebastian N. Höpker, Christopher T. Wood, Martin Schiller, Adam Hartland
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Denaturing mass photometry for rapid optimization of chemical protein-protein cross-linking reactions Nat. Commun. (IF 16.6) Pub Date : 2024-04-25 Hugo Gizardin-Fredon, Paulo E. Santo, Marie-Eve Chagot, Bruno Charpentier, Tiago M. Bandeiras, Xavier Manival, Oscar Hernandez-Alba, Sarah Cianférani
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Efficient ammonia synthesis from the air using tandem non-thermal plasma and electrocatalysis at ambient conditions Nat. Commun. (IF 16.6) Pub Date : 2024-04-25 Wei Liu, Mengyang Xia, Chao Zhao, Ben Chong, Jiahe Chen, He Li, Honghui Ou, Guidong Yang
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Cross-modality mapping using image varifolds to align tissue-scale atlases to molecular-scale measures with application to 2D brain sections Nat. Commun. (IF 16.6) Pub Date : 2024-04-25 Kaitlin M. Stouffer, Alain Trouvé, Laurent Younes, Michael Kunst, Lydia Ng, Hongkui Zeng, Manjari Anant, Jean Fan, Yongsoo Kim, Xiaoyin Chen, Mara Rue, Michael I. Miller
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The antimicrobial fibupeptide lugdunin forms water-filled channel structures in lipid membranes Nat. Commun. (IF 16.6) Pub Date : 2024-04-25 Dominik Ruppelt, Marius F. W. Trollmann, Taulant Dema, Sebastian N. Wirtz, Hendrik Flegel, Sophia Mönnikes, Stephanie Grond, Rainer A. Böckmann, Claudia Steinem
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Nanosecond anomaly detection with decision trees and real-time application to exotic Higgs decays Nat. Commun. (IF 16.6) Pub Date : 2024-04-25 S. T. Roche, Q. Bayer, B. T. Carlson, W. C. Ouligian, P. Serhiayenka, J. Stelzer, T. M. Hong
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Empowering high-dimensional optical fiber communications with integrated photonic processors Nat. Commun. (IF 16.6) Pub Date : 2024-04-25 Kaihang Lu, Zengqi Chen, Hao Chen, Wu Zhou, Zunyue Zhang, Hon Ki Tsang, Yeyu Tong
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Planar thermal Hall effect from phonons in a Kitaev candidate material Nat. Commun. (IF 16.6) Pub Date : 2024-04-25 Lu Chen, Étienne Lefrançois, Ashvini Vallipuram, Quentin Barthélemy, Amirreza Ataei, Weiliang Yao, Yuan Li, Louis Taillefer
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Audio long read: Why loneliness is bad for your health Nature (IF 64.8) Pub Date : 2024-04-26
Listen to an audio version of a recent Nature Feature.
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Could a rare mutation that causes dwarfism also slow ageing? Nature (IF 64.8) Pub Date : 2024-04-26
People with Laron syndrome have a low risk of heart disease and a number of other age-related disorders, hinting at strategies for new treatments.
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Future of Humanity Institute shuts: what’s next for ‘deep future’ research? Nature (IF 64.8) Pub Date : 2024-04-26
Researchers from several disciplines hope to predict — and prevent — scenarios that pose risks to humanity.
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Garden-variety fungus is an expert at environmental clean-ups Nature (IF 64.8) Pub Date : 2024-04-25
The common fungus Aspergillus niger removes both heavy metals and organic pollutants from its surroundings.
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Air-travel climate-change emissions detailed for nearly 200 nations Nature (IF 64.8) Pub Date : 2024-04-25
Carbon emissions from flights that departed from low- and middle-income countries in 2019 totalled 417 million tonnes.
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Rat neurons repair mouse brains — and restore sense of smell Nature (IF 64.8) Pub Date : 2024-04-25
Scientists develop hybrid mice by filling in missing cells and structures in their brains with rat stem cells.
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Hello puffins, goodbye belugas: changing Arctic fjord hints at our climate future Nature (IF 64.8) Pub Date : 2024-04-25
Stunning images show an ecosystem’s upheaval as it warms at an alarming pace.
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Scientists urged to collect royalties from the ‘magic money tree’ Nature (IF 64.8) Pub Date : 2024-04-25
By joining a collecting society, researchers can ensure they are paid when copyrighted book content and papers are reproduced.
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Daily briefing: How an unlikely friendship with Jung influenced Pauli’s physics Nature (IF 64.8) Pub Date : 2024-04-25
A patient-analyst relationship to psychoanalyst Carl Jung that evolved into a friendship deeply influenced physicist Wolfgang Pauli’s work. Plus, organoids shed light on cancer and other diseases, and medieval graves reveal secrets of a mysterious nomadic people.
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NIH pay raise for postdocs and PhD students could have US ripple effect Nature (IF 64.8) Pub Date : 2024-04-25
Salary increases for the 17,000-plus recipients of an NIH research award could lead to increases in other academic settings.
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Bird flu in US cows: is the milk supply safe? Nature (IF 64.8) Pub Date : 2024-04-25
Pasteurized milk is probably not a threat to people, but fresh milk droplets on milking equipment could be spreading the virus in a herd.
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Judge dismisses superconductivity physicist’s lawsuit against university Nature (IF 64.8) Pub Date : 2024-04-25
Ranga Dias sued his university, in part, for allegedly conducting a biased investigation, which found he had committed extensive scientific misconduct.
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Daily briefing: The origins of bioluminescence in animals date back over half a billion years Nature (IF 64.8) Pub Date : 2024-04-24
Octocorals probably evolved the ability to make light when the first animals developed eyes. Plus, the WHO has redefined ‘airborne transmission’ and how artificial intelligence is changing weapons of war.
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How DNA encodes the start of transcription Science (IF 56.9) Pub Date : 2024-04-26 Jun Wang, Vikram Agarwal
The central dogma of molecular biology outlines the flow of genetic information from DNA to RNA to proteins. With a limited vocabulary of four nucleotides (A, C, G, and T), DNA encodes an extensive instruction set, including the chromosomal positions where RNAs begin to be transcribed and the magnitudes of their expression. This process, known as transcription initiation (1), begins at transcription
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Continuous germinal center invasion contributes to the diversity of the immune response Cell (IF 64.5) Pub Date : 2024-04-23 Thomas Hägglöf, Melissa Cipolla, Maximilian Loewe, Spencer T. Chen, Ervin E. Kara, Luka Mesin, Harald Hartweger, Mohamed A. ElTanbouly, Alice Cho, Anna Gazumyan, Victor Ramos, Leonidas Stamatatos, Thiago Y. Oliveira, Michel C. Nussenzweig, Charlotte Viant
No Abstract
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From periphery to center stage: 50 years of advancements in innate immunity Cell (IF 64.5) Pub Date : 2024-04-25 Susan Carpenter, Luke A.J. O’Neill
Over the past 50 years in the field of immunology, something of a Copernican revolution has happened. For a long time, immunologists were mainly concerned with what is termed adaptive immunity, which involves the exquisitely specific activities of lymphocytes. But the other arm of immunity, so-called “innate immunity,” had been neglected. To celebrate Cell’s 50th anniversary, we have put together a
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Principles and therapeutic applications of adaptive immunity Cell (IF 64.5) Pub Date : 2024-04-25 Hongbo Chi, Marion Pepper, Paul G. Thomas
Adaptive immunity provides protection against infectious and malignant diseases. These effects are mediated by lymphocytes that sense and respond with targeted precision to perturbations induced by pathogens and tissue damage. Here, we review key principles underlying adaptive immunity orchestrated by distinct T cell and B cell populations and their extensions to disease therapies. We discuss the intracellular
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Exploring new perspectives in immunology Cell (IF 64.5) Pub Date : 2024-04-25 Ruslan Medzhitov, Akiko Iwasaki
Several conceptual pillars form the foundation of modern immunology, including the clonal selection theory, antigen receptor diversity, immune memory, and innate control of adaptive immunity. However, some immunological phenomena cannot be explained by the current framework. Thus, we still do not know how to design vaccines that would provide long-lasting protective immunity against certain pathogens
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The plant immune system: From discovery to deployment Cell (IF 64.5) Pub Date : 2024-04-25 Jonathan D.G. Jones, Brian J. Staskawicz, Jeffery L. Dangl
Plant diseases cause famines, drive human migration, and present challenges to agricultural sustainability as pathogen ranges shift under climate change. Plant breeders discovered Mendelian genetic loci conferring disease resistance to specific pathogen isolates over 100 years ago. Subsequent breeding for disease resistance underpins modern agriculture and, along with the emergence and focus on model
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Many paths lead to immunology Cell (IF 64.5) Pub Date : 2024-04-25 Ana J. García-Sáez, Ana I. Domingos, J. Silvio Gutkind, Seema Mattoo, Peng Du
While some people pore over the textbook and train through the classics of the field, many scientists come to immunology when they discover it intersecting with their “first love” interests. Five of these “accidental immunologists” tell us how they found their way to a fascination with the immune system.
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A glycolytic metabolite that drives BRCA2 haploinsufficiency Cell (IF 64.5) Pub Date : 2024-04-25 Peng Jiang
Many types of tumor cells alter metabolic pathways to meet their energy and biosynthetic demands for proliferation or stress adaptation. In this issue of Cell, Kong et al. find that the glycolytic metabolite methylglyoxal causes cancer-associated mutant single-base substitution features by inducing BRCA2 proteolysis, leading to functional haploinsufficiency of BRCA2.
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Mapping the pancancer metastasis tumor microbiome Cell (IF 64.5) Pub Date : 2024-04-25 Chi Chun Wong, Jun Yu
The landscape of the intratumoral microbiome in tumor metastases is largely unchartered. In this issue of Cell, Voest et al. profiled the tumor metastasis-associated microbiome in a pancancer cohort of 4,160 biopsies from 26 cancer types. This dataset offers a useful resource for understanding the role of the microbiome in metastatic cancers.
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Generation of rat forebrain tissues in mice Cell (IF 64.5) Pub Date : 2024-04-25 Jia Huang, Bingbing He, Xiali Yang, Xin Long, Yinghui Wei, Leijie Li, Min Tang, Yanxia Gao, Yuan Fang, Wenqin Ying, Zikang Wang, Chao Li, Yingsi Zhou, Shuaishuai Li, Linyu Shi, Seungwon Choi, Haibo Zhou, Fan Guo, Hui Yang, Jun Wu
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Functional sensory circuits built from neurons of two species Cell (IF 64.5) Pub Date : 2024-04-25 Benjamin T. Throesch, Muhammad Khadeesh bin Imtiaz, Rodrigo Muñoz-Castañeda, Masahiro Sakurai, Andrea L. Hartzell, Kiely N. James, Alberto R. Rodriguez, Greg Martin, Giordano Lippi, Sergey Kupriyanov, Zhuhao Wu, Pavel Osten, Juan Carlos Izpisua Belmonte, Jun Wu, Kristin K. Baldwin
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Positive selection CRISPR screens reveal a druggable pocket in an oligosaccharyltransferase required for inflammatory signaling to NF-κB Cell (IF 64.5) Pub Date : 2024-04-25 Benjamin L. Lampson, Ana S. Ramίrez, Marta Baro, Lixia He, Mudra Hegde, Vidyasagar Koduri, Jamie L. Pfaff, Ruth E. Hanna, Julia Kowal, Nitin H. Shirole, Yanfeng He, John G. Doench, Joseph N. Contessa, Kaspar P. Locher, William G. Kaelin
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Collapse of carbon nanotubes due to local high-pressure from van der Waals encapsulation Nat. Commun. (IF 16.6) Pub Date : 2024-04-25 Cheng Hu, Jiajun Chen, Xianliang Zhou, Yufeng Xie, Xinyue Huang, Zhenghan Wu, Saiqun Ma, Zhichun Zhang, Kunqi Xu, Neng Wan, Yueheng Zhang, Qi Liang, Zhiwen Shi
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WindSeer: real-time volumetric wind prediction over complex terrain aboard a small uncrewed aerial vehicle Nat. Commun. (IF 16.6) Pub Date : 2024-04-25 Florian Achermann, Thomas Stastny, Bogdan Danciu, Andrey Kolobov, Jen Jen Chung, Roland Siegwart, Nicholas Lawrance