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  • Determination of Anthocyanins and Antioxidants in ‘Titanbicus’ Edible Flowers In Vitro and In Vivo
    Plant Foods Hum. Nutr. (IF 2.598) Pub Date : 2020-04-04
    Sasicha Chensom, Yasuhito Shimada, Hiroko Nakayama, Kumi Yoshida, Tadao Kondo, Hirotaka Katsuzaki, Sachiko Hasegawa, Takashi Mishima

    Abstract Titanbicus (TB), a hybrid of Hibiscus moscheutos × H. coccineus (Medic.) Walt., has potential to be used as an edible flower. In this study, proximate nutritional content, anthocyanin content, total polyphenol content (TPC), and antioxidant activities in vitro and in vivo were investigated. Three cultivars of TB, namely Artemis (AR), Rhea (R), and Adonis (AD), were used as materials. Protein

    更新日期:2020-04-06
  • Biophysics to Ecology
    Her. Russ. Acad. Sci. (IF 0.492) Pub Date : 2020-02-04
    I. I. Gitel’zon

    Abstract This report presents some new methodological opportunities that biophysics can offer for solving the fundamental problem of planetary ecology—deciphering the mechanism that maintains the equilibrium state of the biosphere. The Institute of Biophysics, Siberian Branch, Russian Academy of Sciences, where the author of this report works, is developing two complementary directions in ecological

    更新日期:2020-04-06
  • Efficient Energy Conversion and Storage Based on Robust Fluoride‐Free Self‐Assembled 1D Niobium Carbide in 3D Nanowire Network
    Adv. Sci. (IF 15.804) Pub Date : 2020-04-06
    Sin‐Yi Pang; Weng‐Fu Io; Lok‐Wing Wong; Jiong Zhao; Jianhua Hao
    更新日期:2020-04-06
  • Optimized Metal Chalcogenides for Boosting Water Splitting
    Adv. Sci. (IF 15.804) Pub Date : 2020-04-06
    Jie Yin; Jing Jin; Honghong Lin; Zhouyang Yin; Jianyi Li; Min Lu; Linchuan Guo; Pinxian Xi; Yu Tang; Chun‐Hua Yan
    更新日期:2020-04-06
  • Thymoquinone synergizes with arsenic and interferon alpha to target human T-cell leukemia/lymphoma
    Life Sci. (IF 3.448) Pub Date : 2020-04-06
    Marwa Houssein; Maamoun Fatfat; Zeina Habli; Nasab Ghazal; Sara Mokdad; Hala Khalife; Mahmoud Khalil; Hala Gali-Muhtasib
    更新日期:2020-04-06
  • Adipose specific aptamer adipo-8 recognizes and interacts with APMAP to ameliorates fat deposition in vitro and in vivo
    Life Sci. (IF 3.448) Pub Date : 2020-04-06
    Wen Zhong; Yin Zhang; Weihong Tan; Jiani Zhang; Jun Liu; Guodong Wang; Jie Liao; Bo Liu; Ke Chen; Bo Yu; Yuanyuan Deng; Yanbo Zou; Ying Pu; Huixia Liu

    Aims To identify the target of an adipose specific aptamer adipo-8, predict the potential interaction between adipo-8 and its target, and investigate lipid-lowering effect of adipo-8 in vitro and in vivo. Main methods Distinct membranous protein of 3T3-L1 adipocyte pulled-down by adipo-8 was mass-spectrometry analyzed as target candidate(s), and affinity of adipo-8 to target protein-silent adipocyte

    更新日期:2020-04-06
  • Effects of high intensity interval training (up&downward running) with BCAA/nano chitosan on Foxo3 and SMAD soleus muscles of aging rat
    Life Sci. (IF 3.448) Pub Date : 2020-04-06
    Salime Sadri; Gholamreza Sharifi; Khosro Jalali Dehkordi

    Aims The aim of this study was investigate the effects of 8 weeks of high intensity interval training (HIIT, up&downward running) with BCAA/nano chitosan on Foxo3 and SMAD soleus muscles of aging rats. Main methods In this experimental study thirty male rats were randomly divided into six groups of control, BCAA with Nano chitosan (Supplement, (Sup)), upslope running, downslope running, upslope running+Sup

    更新日期:2020-04-06
  • Comparison of the cardiac effects of electronic cigarette aerosol exposure with waterpipe and combustible cigarette smoke exposure in rats
    Life Sci. (IF 3.448) Pub Date : 2020-04-05
    F. Mayyas; Hala Aldawod; K.H. Alzoubi; Omar Khabour; Alan Shihadeh; Thomas Eissenberg

    Aims Electronic cigarette (ECIG) has been used as an alternative to tobacco smoking as it lacks the majority of toxicants found in tobacco smoke. However, the effect of ECIG aerosol inhalation on cardiac health are not well studied. The present study aimed to compare the effects of ECIGs with that of combustible tobacco cigarette (T-Cigs) and waterpipe (WP) smoke on cardiac biomarkers of oxidative

    更新日期:2020-04-06
  • Cordycepin protects against acute pancreatitis by modulating NF-κB and NLRP3 inflammasome activation via AMPK
    Life Sci. (IF 3.448) Pub Date : 2020-04-05
    Jing Yang; Yiwen Zhou; Jinsong Shi

    Acute pancreatitis (AP) is a noninfectious inflammatory disease with high morbidity and mortality, which is characterized by severe inflammation and tissue necrosis. Cordycepin (CRD), derived from Cordyceps militaris, possesses anti-inflammatory effects and immunomodulation properties. Here, we investigated the protective effects of CRD on pancreatic injury and clarified potential mechanisms in AP

    更新日期:2020-04-06
  • Nifuroxazide attenuates experimentally-induced hepatic encephalopathy and the associated hyperammonemia and cJNk/caspase-8/TRAIL activation in rats
    Life Sci. (IF 3.448) Pub Date : 2020-04-04
    Ahmed E. Khodir; Eman Said

    Hyperammonemia is a serious metabolic disorder associating with hepatic encephalopathy (HE) which occurs secondary to several forms of liver injury ranging from simple acute liver failure (ALF) to its most serious form; cirrhosis. The resent study highlights the possible ameliorative effect of oral nifuroxazide (25 mg/kg) against experimentally induced ALF and the subsequent HE in a well-standardized

    更新日期:2020-04-06
  • Polyphyllin I attenuates pressure over-load induced cardiac hypertrophy via inhibition of Wnt/β-catenin signaling pathway
    Life Sci. (IF 3.448) Pub Date : 2020-04-04
    Qing Li; Wei Jiang; Zhaofei Wan; Yajuan Ni; Lei Lei; Jin Wei

    Aims Cardiac hypertrophy is one of most important risk factors for cardiovascular mortality. Activation of Wnt/β-catenin signaling pathway is acknowledged to be an important mechanism for pathogenesis of cardiac hypertrophy. Polyphyllin I (PPI), a component in the traditional Chinese medicinal herb, has shown anticancer effect partially via interruption of Wnt/β-catenin signaling pathway. Our aim was

    更新日期:2020-04-06
  • Inhibition of the P2X7 receptor improves renal function via renin-angiotensin system and nitric oxide on diabetic nephropathy in rats
    Life Sci. (IF 3.448) Pub Date : 2020-04-04
    M. Nascimento; G.R. Punaro; R.S. Serralha; D.L. Yorgos; M.G. Mouro; I.C. Oliveira; D.E. Casarini; A.M. Rodrigues; E.M.S. Higa

    Aim To evaluate the effects of P2X7 receptor blockade on renin-angiotensin system (RAS) in rats with diabetic nephropathy (DN). Main methods Wistar rats were unilaterally nephrectomized and received streptozotocin for diabetes mellitus (DM) induction; control animals (CTL) received the drug vehicle. The animals were submitted to P2X7 receptor silencing, forming the group (DM + siRNA). The animals were

    更新日期:2020-04-06
  • Ginsenoside Rg1-induced activation of astrocytes promotes functional recovery via the PI3K/Akt signaling pathway following spinal cord injury
    Life Sci. (IF 3.448) Pub Date : 2020-04-04
    Long Xu; Yin-Yao Tang; Xing-Lei Ben; Mao-Hua Cheng; Wei-Xiao Guo; Yun Liu; Zheng-Feng Lu; Jie-Lin Deng

    Aims To determine whether ginsenoside Rg1 is involved in scratch wound healing through altered expression of related molecules in astrocytes and improved functional recovery after spinal cord injury (SCI). Materials and methods Astrocytes were isolated from rats, followed by Rg1 treatment. The wound healing test was performed to observe the scratch wound healing in different groups. The expression

    更新日期:2020-04-06
  • Inhibition of the NLRP3 inflammasome reduces brain edema and regulates the distribution of aquaporin-4 after cerebral ischaemia-reperfusion
    Life Sci. (IF 3.448) Pub Date : 2020-04-03
    Haining Wang; Hongping Chen; Jing Jin; Qingqing Liu; Di Zhong; Guozhong Li

    Aims Brain edema is a common threat to life in ischaemic brain injury. The NLRP3 inflammasome promotes the inflammatory injury after ischaemic stroke. Previous studies have shown that aquaporin-4 (AQP4) modulates brain water transport and endothelin-1 (ET-1) induces cerebral edema. However, the contribution of the NLRP3 inflammasome to regulation of brain edema and blood-brain barrier (BBB) disruption

    更新日期:2020-04-06
  • The biological function of BMAL1 in skeleton development and disorders
    Life Sci. (IF 3.448) Pub Date : 2020-04-03
    Guangjin Chen; Qingming Tang; Shaoling Yu; Yaning Xie; Jiwei Sun; Shue Li; Lili Chen
    更新日期:2020-04-06
  • Structural investigation on the selective COX-2 inhibitors mediated cardiotoxicity: A review
    Life Sci. (IF 3.448) Pub Date : 2020-04-03
    Mohit Arora; Shalki Choudhary; Pankaj Kumar Singh; Bharti Sapra; Om Silakari
    更新日期:2020-04-06
  • High ErbB3 activating activity in human blood is not due to circulating neuregulin-1 beta
    Life Sci. (IF 3.448) Pub Date : 2020-04-03
    Emmanuel Boateng; Joanne T. deKay; Sarah M. Peterson; Jacob Boles; Nathan Pinnette; Mary W. Sorcher; Michael P. Robich; Douglas B. Sawyer; Sergey Ryzhov

    Neuregulin-1β (NRG-1) is a membrane-bound or secreted growth and differentiation factor that mediates its action by binding to ErbB receptors. Circulating levels of NRG-1 are characterized by large inter-individual variability with the range of absolute values covering two orders of magnitude, from hundreds to tens of thousands of picograms per milliliter of blood. NRG-1 signaling via ErbB receptors

    更新日期:2020-04-06
  • Virtual screening and repurposing of FDA approved drugs against COVID-19 main protease
    Life Sci. (IF 3.448) Pub Date : 2020-04-03
    Mahmoud Kandeel; Mohammed Al-Nazawi

    Aims In December 2019, the Coronavirus disease-2019 (COVID-19) virus has emerged in Wuhan, China. In this research, the first resolved COVID-19 crystal structure (main protease) was targeted in a virtual screening study by of FDA approved drugs dataset. In addition, a knowledge gap in relations of COVID-19 with the previously known fatal Coronaviruses (CoVs) epidemics, SARS and MERS CoVs, was covered

    更新日期:2020-04-06
  • Berberine attenuates Aβ42-induced neuronal damage through regulating circHDAC9/miR-142-5p axis in human neuronal cells
    Life Sci. (IF 3.448) Pub Date : 2020-04-03
    Nan Zhang; Yiwen Gao; Shaoli Yu; Xiaohong Sun; Ke Shen

    Background Berberine plays a neuroprotective role in neurodegenerative diseases, including Alzheimer's disease (AD). Circular RNAs (circRNAs) function as crucial players in AD pathogenesis. In the current work, we aimed to investigate whether circRNA histone deacetylase 9 (circHDAC9) was involved in the regulation of berberine in AD. Methods Cell viability and apoptosis were determined by the Cell

    更新日期:2020-04-06
  • Depression: a new enzyme AT play
    EMBO Rep. (IF 8.383) Pub Date : 2020-03-05
    Helena Caria Martins; Gerhard Schratt

    Neuronal activity is the main contributor to the high‐energy demand of the human brain. ATP is needed for the maintenance of ionic gradients, neurotransmitter transport, and release, as well as the signaling pathways that follow activation of post‐synaptic receptors. The inability to maintain a high supply of ATP through tight regulatory mechanisms can, therefore, have severe consequences for brain

    更新日期:2020-04-06
  • Linking m6 A to Wnt signaling.
    EMBO Rep. (IF 8.383) Pub Date : 2020-02-20
    Xiao-Min Liu,Shu-Bing Qian

    N6 -methyladenosine (m6 A) has emerged as a crucial molecular code to influence pluripotency and differentiation of diverse stem cells. A study in this issue now shows that, in intestinal stem cells, the m6 A reader protein YTHDF1 directs translational control of stemness in both m6 A- and Wnt-dependent manner [1].

    更新日期:2020-04-06
  • Exosomes take (germinal) center stage
    EMBO Rep. (IF 8.383) Pub Date : 2020-03-09
    Jennifer Pérez‐Boza; Dirk M Pegtel

    Efficient antibody production is a crucial step during immune responses leading to pathogen clearance and neutralization. Immune synapses, contact points between T and B lymphocytes in the presence of an antigen, are necessary to initiate the proliferation and differentiation of B cells in the germinal center. In this issue of EMBO Reports, Fernández‐Messina et al [1] present evidence of microRNA transfer

    更新日期:2020-04-06
  • Mitochondrial DNA in inflammation and immunity
    EMBO Rep. (IF 8.383) Pub Date : 2020-03-23
    Joel S Riley; Stephen WG Tait

    Mitochondria are cellular organelles that orchestrate a vast range of biological processes, from energy production and metabolism to cell death and inflammation. Despite this seemingly symbiotic relationship, mitochondria harbour within them a potent agonist of innate immunity: their own genome. Release of mitochondrial DNA into the cytoplasm and out into the extracellular milieu activates a plethora

    更新日期:2020-04-06
  • Transfer of extracellular vesicle-microRNA controls germinal center reaction and antibody production.
    EMBO Rep. (IF 8.383) Pub Date : 2020-02-19
    Lola Fernández-Messina,Ana Rodríguez-Galán,Virginia G de Yébenes,Cristina Gutiérrez-Vázquez,Sandra Tenreiro,Miguel C Seabra,Almudena R Ramiro,Francisco Sánchez-Madrid

    Intercellular communication orchestrates effective immune responses against disease-causing agents. Extracellular vesicles (EVs) are potent mediators of cell-cell communication. EVs carry bioactive molecules, including microRNAs, which modulate gene expression and function in the recipient cell. Here, we show that formation of cognate primary T-B lymphocyte immune contacts promotes transfer of a very

    更新日期:2020-04-06
  • Loss of non-canonical KCC2 functions promotes developmental apoptosis of cortical projection neurons.
    EMBO Rep. (IF 8.383) Pub Date : 2020-02-17
    Martina Mavrovic,Pavel Uvarov,Eric Delpire,Laszlo Vutskits,Kai Kaila,Martin Puskarjov

    KCC2, encoded in humans by the SLC12A5 gene, is a multifunctional neuron-specific protein initially identified as the chloride (Cl- ) extruder critical for hyperpolarizing GABAA receptor currents. Independently of its canonical function as a K-Cl cotransporter, KCC2 regulates the actin cytoskeleton via molecular interactions mediated through its large intracellular C-terminal domain (CTD). Contrary

    更新日期:2020-04-06
  • Proteasome mapping reveals sexual dimorphism in tissue-specific sensitivity to protein aggregations.
    EMBO Rep. (IF 8.383) Pub Date : 2020-02-23
    Edmund Charles Jenkins,Nagma Shah,Maria Gomez,Gabriella Casalena,Dazhi Zhao,Timothy C Kenny,Sara Rose Guariglia,Giovanni Manfredi,Doris Germain

    Defects in the proteasome can result in pathological proteinopathies. However, the pathogenic role of sex- and tissue-specific sensitivity to proteotoxic stress remains elusive. Here, we map the proteasome activity across nine tissues, in male and female mice, and demonstrate strong sexual dimorphism in proteasome activity, where females have significantly higher activity in several tissues. Further

    更新日期:2020-04-06
  • Human RAP1 specifically protects telomeres of senescent cells from DNA damage
    EMBO Rep. (IF 8.383) Pub Date : 2020-02-25
    Liudmyla Lototska; Jia‐Xing Yue; Jing Li; Marie‐Josèphe Giraud‐Panis; Zhou Songyang; Nicola J Royle; Gianni Liti; Jing Ye; Eric Gilson; Aaron Mendez‐Bermudez

    Repressor/activator protein 1 (RAP1) is a highly evolutionarily conserved protein found at telomeres. Although yeast Rap1 is a key telomere capping protein preventing non‐homologous end joining (NHEJ) and consequently telomere fusions, its role at mammalian telomeres in vivo is still controversial. Here, we demonstrate that RAP1 is required to protect telomeres in replicative senescent human cells

    更新日期:2020-04-06
  • Optogenetic control of mitochondrial protonmotive force to impact cellular stress resistance.
    EMBO Rep. (IF 8.383) Pub Date : 2020-02-11
    Brandon J Berry,Adam J Trewin,Alexander S Milliken,Aksana Baldzizhar,Andrea M Amitrano,Yunki Lim,Minsoo Kim,Andrew P Wojtovich

    Mitochondrial respiration generates an electrochemical proton gradient across the mitochondrial inner membrane called protonmotive force (PMF) to drive diverse functions and synthesize ATP. Current techniques to manipulate the PMF are limited to its dissipation; yet, there is no precise and reversible method to increase the PMF. To address this issue, we aimed to use an optogenetic approach and engineered

    更新日期:2020-04-06
  • MEX3A regulates Lgr5+ stem cell maintenance in the developing intestinal epithelium.
    EMBO Rep. (IF 8.383) Pub Date : 2020-02-13
    Bruno Pereira,Ana L Amaral,Alexandre Dias,Nuno Mendes,Vanesa Muncan,Ana R Silva,Chantal Thibert,Anca G Radu,Leonor David,Valdemar Máximo,Gijs R van den Brink,Marc Billaud,Raquel Almeida

    Intestinal stem cells (ISCs) fuel the lifelong self-renewal of the intestinal tract and are paramount for epithelial repair. In this context, the Wnt pathway component LGR5 is the most consensual ISC marker to date. Still, the effort to better understand ISC identity and regulation remains a challenge. We have generated a Mex3a knockout mouse model and show that this RNA-binding protein is crucial

    更新日期:2020-04-06
  • Hippocampal CD39/ENTPD1 promotes mouse depression‐like behavior through hydrolyzing extracellular ATP
    EMBO Rep. (IF 8.383) Pub Date : 2020-03-05
    Qian‐Qian Cui; Zhuang‐Li Hu; Yuan‐Lang Hu; Xi Chen; Ji Wang; Li Mao; Xiao‐Jia Lu; Ming Ni; Jian‐Guo Chen; Fang Wang

    Emerging evidence implicates that low levels of ATP in the extracellular space may contribute to the pathophysiology of major depressive disorder (MDD). The concentration of extracellular ATP is regulated by its hydrolase ectonucleotide tri(di)phosphohydrolase (ENTPD). However, the role of ENTPD in depression remains poorly understood. Here we examine the role of CD39 (known as ENTPD1) in mouse depression‐like

    更新日期:2020-04-06
  • YTHDF1-mediated translation amplifies Wnt-driven intestinal stemness.
    EMBO Rep. (IF 8.383) Pub Date : 2020-02-17
    Bing Han,Sujun Yan,Saisai Wei,Jie Xiang,Kangli Liu,Zhanghui Chen,Rongpan Bai,Jinghao Sheng,Zhengping Xu,Xiangwei Gao

    N6-methyladenosine (m6 A) mRNA methylation has emerged as an important player in many biological processes by regulating gene expression. However, its roles in intestinal stem cell (ISC) homeostasis remain largely unknown. Here, we report that YTHDF1, an m6 A reader, is highly expressed in ISCs and its expression is upregulated by Wnt signaling at the translational level. Whereas YTHDF1 is dispensable

    更新日期:2020-04-06
  • Chemokines and galectins form heterodimers to modulate inflammation.
    EMBO Rep. (IF 8.383) Pub Date : 2020-02-21
    Veit Eckardt,Michelle C Miller,Xavier Blanchet,Rundan Duan,Julian Leberzammer,Johan Duchene,Oliver Soehnlein,Remco Ta Megens,Anna-Kristin Ludwig,Aurelio Dregni,Alexander Faussner,Kanin Wichapong,Hans Ippel,Ingrid Dijkgraaf,Herbert Kaltner,Yvonne Döring,Kiril Bidzhekov,Tilman M Hackeng,Christian Weber,Hans-Joachim Gabius,Philipp von Hundelshausen,Kevin H Mayo

    Chemokines and galectins are simultaneously upregulated and mediate leukocyte recruitment during inflammation. Until now, these effector molecules have been considered to function independently. Here, we tested the hypothesis that they form molecular hybrids. By systematically screening chemokines for their ability to bind galectin-1 and galectin-3, we identified several interacting pairs, such as

    更新日期:2020-04-06
  • SIRT2‐dependent IDH1 deacetylation inhibits colorectal cancer and liver metastases
    EMBO Rep. (IF 8.383) Pub Date : 2020-03-05
    Bo Wang; Yingjiang Ye; Xin Yang; Boya Liu; Zhe Wang; Shuaiyi Chen; Kewei Jiang; Wei Zhang; Hongpeng Jiang; Harri Mustonen; Pauli Puolakkainen; Shan Wang; Jianyuan Luo; Zhanlong Shen

    Protein lysine acetylation affects colorectal cancer (CRC) distant metastasis through multiple pathways. In a previous proteomics screen, we found that isocitrate dehydrogenase 1 (IDH1) is hyperacetylated in CRC primary tumors and liver metastases. Here, we further investigate the function of IDH1 hyperacetylation at lysine 224 in CRC progression. We find that IDH1 K224 deacetylation promotes its enzymatic

    更新日期:2020-04-06
  • Homeobox A4 suppresses vascular remodeling by repressing YAP/TEAD transcriptional activity
    EMBO Rep. (IF 8.383) Pub Date : 2020-03-09
    Masahiro Kimura; Takahiro Horie; Osamu Baba; Yuya Ide; Shuhei Tsuji; Randolph Ruiz Rodriguez; Toshimitsu Watanabe; Tomohiro Yamasaki; Chiharu Otani; Sijia Xu; Yui Miyasaka; Yasuhiro Nakashima; Takeshi Kimura; Koh Ono

    The Hippo signaling pathway is involved in the pathophysiology of various cardiovascular diseases. Yes‐associated protein (YAP) and transcriptional enhancer activator domain (TEAD) transcriptional factors, the main transcriptional complex of the Hippo pathway, were recently identified as modulators of phenotypic switching of vascular smooth muscle cells (VSMCs). However, the intrinsic regulator of

    更新日期:2020-04-06
  • Androgen receptor-regulated circFNTA activates KRAS signaling to promote bladder cancer invasion.
    EMBO Rep. (IF 8.383) Pub Date : 2020-02-13
    Jinbo Chen,Yin Sun,Zhenyu Ou,Shuyuan Yeh,Chi-Ping Huang,Bosen You,Yu-Chieh Tsai,Tzong-Jen Sheu,Xiongbing Zu,Chawnshang Chang

    The androgen receptor (AR) has been linked to bladder cancer (BCa) progression, but if this involves circular RNAs (circRNAs) remains unclear. Here, we find that AR alters the levels of circRNA-FNTA (circFNTA) to increase BCa cell invasion and chemo-resistance. Mechanistically, AR represses the RNA editing gene ADAR2 via direct binding to its 5' promoter region to increase circFNTA levels, which then

    更新日期:2020-04-06
  • USP1 deubiquitinates Akt to inhibit PI3K‐Akt‐FoxO signaling in muscle during prolonged starvation
    EMBO Rep. (IF 8.383) Pub Date : 2020-03-05
    Dana Goldbraikh; Danielle Neufeld; Yara Eid‐Mutlak; Inbal Lasry; Jennifer E Gilda; Anna Parnis; Shenhav Cohen

    PI3K‐Akt‐FoxO‐mTOR signaling is the central pathway controlling growth and metabolism in all cells. Ubiquitination of the protein kinase Akt prior to its phosphorylation is required for PI3K‐Akt activity. Here, we found that the deubiquitinating (DUB) enzyme USP1 removes K63‐linked polyubiquitin chains on Akt to restrict PI3K‐Akt‐FoxO signaling in mouse muscle during prolonged starvation. DUB screening

    更新日期:2020-04-06
  • LncRNA GUARDIN suppresses cellular senescence through a LRP130‐PGC1α‐FOXO4‐p21‐dependent signaling axis
    EMBO Rep. (IF 8.383) Pub Date : 2020-03-09
    Xuedan Sun; Rick Francis Thorne; Xu Dong Zhang; Miao He; Jinming Li; Shanshan Feng; Xiaoying Liu; Mian Wu

    The long noncoding RNA GUARDIN functions to protect genome stability. Inhibiting GUARDIN expression can alter cell fate decisions toward senescence or apoptosis, but the underlying molecular signals are unknown. Here, we show that GUARDIN is an essential component of a transcriptional repressor complex involving LRP130 and PGC1α. GUARDIN acts as a scaffold to stabilize LRP130/PGC1α heterodimers and

    更新日期:2020-04-06
  • Cripto shapes macrophage plasticity and restricts EndMT in injured and diseased skeletal muscle.
    EMBO Rep. (IF 8.383) Pub Date : 2020-02-27
    Francescopaolo Iavarone,Ombretta Guardiola,Alessandra Scagliola,Gennaro Andolfi,Federica Esposito,Antonio Serrano,Eusebio Perdiguero,Silvia Brunelli,Pura Muñoz-Cánoves,Gabriella Minchiotti

    Macrophages are characterized by a high plasticity in response to changes in tissue microenvironment, which allows them to acquire different phenotypes and to exert essential functions in complex processes, such as tissue regeneration. Here, we report that the membrane protein Cripto plays a key role in shaping macrophage plasticity in skeletal muscle during regeneration and disease. Conditional deletion

    更新日期:2020-04-06
  • MSCs rescue impaired wound healing in a murine LAD1 model by adaptive responses to low TGF-β1 levels.
    EMBO Rep. (IF 8.383) Pub Date : 2020-02-21
    Dongsheng Jiang,Karmveer Singh,Jana Muschhammer,Susanne Schatz,Anca Sindrilaru,Evgenia Makrantonaki,Yu Qi,Meinhard Wlaschek,Karin Scharffetter-Kochanek

    Mutations in the CD18 gene encoding the common β-chain of β2 integrins result in impaired wound healing in humans and mice suffering from leukocyte adhesion deficiency syndrome type 1 (LAD1). Transplantation of adipose tissue-derived mesenchymal stem cells (MSCs) restores normal healing of CD18-/- wounds by restoring the decreased TGF-β1 concentrations. TGF-β1 released from MSCs leads to enhanced myofibroblast

    更新日期:2020-04-06
  • WDR63 inhibits Arp2/3-dependent actin polymerization and mediates the function of p53 in suppressing metastasis.
    EMBO Rep. (IF 8.383) Pub Date : 2020-03-04
    Kailiang Zhao,Decai Wang,Xiaolong Zhao,Chenfeng Wang,Yongxiang Gao,Kaiyue Liu,Fang Wang,Xianning Wu,Xuejuan Wang,Linfeng Sun,Jianye Zang,Yide Mei

    Accumulating evidence suggests that p53 plays a suppressive role in cancer metastasis, yet the underlying mechanism remains largely unclear. Regulation of actin dynamics is essential for the control of cell migration, which is an important step in metastasis. The Arp2/3 complex is a major nucleation factor to initiate branched actin polymerization that drives cell migration. However, it is unknown

    更新日期:2020-04-06
  • Organismal benefits of transcription speed control at gene boundaries.
    EMBO Rep. (IF 8.383) Pub Date : 2020-02-27
    Xueyuan Leng,Maxim Ivanov,Peter Kindgren,Indranil Malik,Axel Thieffry,Peter Brodersen,Albin Sandelin,Craig D Kaplan,Sebastian Marquardt

    RNA polymerase II (RNAPII) transcription is crucial for gene expression. RNAPII density peaks at gene boundaries, associating these key regions for gene expression control with limited RNAPII movement. The connections between RNAPII transcription speed and gene regulation in multicellular organisms are poorly understood. Here, we directly modulate RNAPII transcription speed by point mutations in the

    更新日期:2020-04-06
  • Adherens junction remodelling during mitotic rounding of pseudostratified epithelial cells.
    EMBO Rep. (IF 8.383) Pub Date : 2020-02-07
    Mario Aguilar-Aragon,Teresa T Bonello,Graham P Bell,Georgina C Fletcher,Barry J Thompson

    Epithelial cells undergo cortical rounding at the onset of mitosis to enable spindle orientation in the plane of the epithelium. In cuboidal epithelia in culture, the adherens junction protein E-cadherin recruits Pins/LGN/GPSM2 and Mud/NuMA to orient the mitotic spindle. In the pseudostratified columnar epithelial cells of Drosophila, septate junctions recruit Mud/NuMA to orient the spindle, while

    更新日期:2020-04-06
  • KUP9 maintains root meristem activity by regulating K+ and auxin homeostasis in response to low K
    EMBO Rep. (IF 8.383) Pub Date : 2020-04-06
    Mei‐Ling Zhang; Pan‐Pan Huang; Yun Ji; Shuwei Wang; Shao‐Shuai Wang; Zhen Li; Yan Guo; Zhaojun Ding; Wei‐Hua Wu; Yi Wang

    Potassium (K) is essential for plant growth and development. Here, we show that the KUP/HAK/KT K+ transporter KUP9 controls primary root growth in Arabidopsis thaliana. Under low‐K+ conditions, kup9 mutants displayed a short‐root phenotype that resulted from reduced numbers of root cells. KUP9 was highly expressed in roots and specifically expressed in quiescent center (QC) cells in root tips. The

    更新日期:2020-04-06
  • The hypertrophic cardiomyopathy mutations R403Q and R663H increase the number of myosin heads available to interact with actin
    Sci. Adv. (IF 12.804) Pub Date : 2020-04-03
    Saswata S. Sarkar, Darshan V. Trivedi, Makenna M. Morck, Arjun S. Adhikari, Shaik N. Pasha, Kathleen M. Ruppel, James A. Spudich

    Hypertrophic cardiomyopathy (HCM) mutations in β-cardiac myosin and myosin binding protein-C (MyBP-C) lead to hypercontractility of the heart, an early hallmark of HCM. We show that hypercontractility caused by the HCM-causing mutation R663H cannot be explained by changes in fundamental myosin contractile parameters, much like the HCM-causing mutation R403Q. Using enzymatic assays with purified human

    更新日期:2020-04-06
  • Evaluating the fake news problem at the scale of the information ecosystem
    Sci. Adv. (IF 12.804) Pub Date : 2020-04-03
    Jennifer Allen, Baird Howland, Markus Mobius, David Rothschild, Duncan J. Watts

    “Fake news,” broadly defined as false or misleading information masquerading as legitimate news, is frequently asserted to be pervasive online with serious consequences for democracy. Using a unique multimode dataset that comprises a nationally representative sample of mobile, desktop, and television consumption, we refute this conventional wisdom on three levels. First, news consumption of any sort

    更新日期:2020-04-06
  • Quantum computation solves a half-century-old enigma: Elusive vibrational states of magnesium dimer found
    Sci. Adv. (IF 12.804) Pub Date : 2020-04-03
    Stephen H. Yuwono, Ilias Magoulas, Piotr Piecuch

    The high-lying vibrational states of the magnesium dimer (Mg2), which has been recognized as an important system in studies of ultracold and collisional phenomena, have eluded experimental characterization for half a century. Until now, only the first 14 vibrational states of Mg2 have been experimentally resolved, although it has been suggested that the ground-state potential may support five additional

    更新日期:2020-04-06
  • Direct observation of minibands in a twisted graphene/WS2 bilayer
    Sci. Adv. (IF 12.804) Pub Date : 2020-04-03
    Søren Ulstrup, Roland J. Koch, Simranjeet Singh, Kathleen M. McCreary, Berend T. Jonker, Jeremy T. Robinson, Chris Jozwiak, Eli Rotenberg, Aaron Bostwick, Jyoti Katoch, Jill A. Miwa

    Stacking two-dimensional (2D) van der Waals materials with different interlayer atomic registry in a heterobilayer causes the formation of a long-range periodic superlattice that may bestow the heterostructure with properties such as new quantum fractal states or superconductivity. Recent optical measurements of transition metal dichalcogenide (TMD) heterobilayers have revealed the presence of hybridized

    更新日期:2020-04-06
  • Layer-resolved ultrafast extreme ultraviolet measurement of hole transport in a Ni-TiO2-Si photoanode
    Sci. Adv. (IF 12.804) Pub Date : 2020-04-03
    Scott K. Cushing, Ilana J. Porter, Bethany R. de Roulet, Angela Lee, Brett M. Marsh, Szilard Szoke, Mihai E. Vaida, Stephen R. Leone

    Metal oxide semiconductor junctions are central to most electronic and optoelectronic devices, but ultrafast measurements of carrier transport have been limited to device-average measurements. Here, charge transport and recombination kinetics in each layer of a Ni-TiO2-Si junction is measured using the element specificity of broadband extreme ultraviolet (XUV) ultrafast pulses. After silicon photoexcitation

    更新日期:2020-04-06
  • Role of allosteric switches and adaptor domains in long-distance cross-talk and transient tunnel formation
    Sci. Adv. (IF 12.804) Pub Date : 2020-04-03
    Nandini Sharma, Navjeet Ahalawat, Padmani Sandhu, Erick Strauss, Jagannath Mondal, Ruchi Anand

    Transient tunnels that assemble and disassemble to facilitate passage of unstable intermediates in enzymes containing multiple reaction centers are controlled by allosteric cues. Using the 140-kDa purine biosynthetic enzyme PurL as a model system and a combination of biochemical and x-ray crystallographic studies, we show that long-distance communication between ~25-Å distal active sites is initiated

    更新日期:2020-04-06
  • Methanotrophic bacterial symbionts fuel dense populations of deep-sea feather duster worms (Sabellida, Annelida) and extend the spatial influence of methane seepage
    Sci. Adv. (IF 12.804) Pub Date : 2020-04-03
    Shana K. Goffredi, Ekin Tilic, Sean W. Mullin, Katherine S. Dawson, Abigail Keller, Raymond W. Lee, Fabai Wu, Lisa A. Levin, Greg W. Rouse, Erik E. Cordes, Victoria J. Orphan

    Deep-sea cold seeps are dynamic sources of methane release and unique habitats supporting ocean biodiversity and productivity. Here, we describe newly discovered animal-bacterial symbioses fueled by methane, between two species of annelid (a serpulid Laminatubus and sabellid Bispira) and distinct aerobic methane-oxidizing bacteria belonging to the Methylococcales, localized to the host respiratory

    更新日期:2020-04-06
  • A tripartite ssDNA mycovirus from a plant pathogenic fungus is infectious as cloned DNA and purified virions
    Sci. Adv. (IF 12.804) Pub Date : 2020-04-03
    Pengfei Li, Shuangchao Wang, Lihang Zhang, Dewen Qiu, Xueping Zhou, Lihua Guo

    Here, we describe a tripartite circular single-stranded (ss) DNA mycovirus, named Fusarium graminearum gemytripvirus 1 (FgGMTV1). The genome of FgGMTV1 comprises three circular ssDNA segments (DNA-A, DNA-B, and DNA-C). Sequence alignments and phylogenetic analyses showed that FgGMTV1 is nested within the family Genomoviridae. We also constructed the first infectious DNA clones of a DNA mycovirus. Our

    更新日期:2020-04-06
  • “Skin-like” fabric for personal moisture management
    Sci. Adv. (IF 12.804) Pub Date : 2020-04-03
    L. Lao, D. Shou, Y. S. Wu, J. T. Fan

    Personal moisture management fabrics that facilitate sweat transport away from the skin are highly desirable for wearer’s comfort and performance. Here, we demonstrate a “skin-like” directional liquid transport fabric, which enables continuous one-way liquid flow through spatially distributed channels acting like “sweating glands” yet repels external liquid contaminants. The water transmission rate

    更新日期:2020-04-06
  • Massive generation of metastable bulk nanobubbles in water by external electric fields
    Sci. Adv. (IF 12.804) Pub Date : 2020-04-03
    Mohammad Reza Ghaani, Peter G. Kusalik, Niall J. English

    Nanobubbles (NBs) are nanoscopic gaseous domains than can exist on solid surfaces or in bulk liquids. They have attracted substantial attention due to their long-time (meta)stability and a high potential for real-world applications. Using an approach not previously investigated, we exploit surface-electrostatic NB formation and stabilization via application of external electric fields in gas-liquid

    更新日期:2020-04-06
  • A metal-free blue chromophore derived from plant pigments
    Sci. Adv. (IF 12.804) Pub Date : 2020-04-03
    B. C. Freitas-Dörr, C. O. Machado, A. C. Pinheiro, A. B. Fernandes, F. A. Dörr, E. Pinto, M. Lopes-Ferreira, M. Abdellah, J. Sá, L. C. Russo, F. L. Forti, L. C. P. Gonçalves, E. L. Bastos

    Blue natural pigments are rare, especially among plants. However, flowering species that evolved to attract Hymenoptera pollinators are colored by blue anthocyanin-metal complexes. Plants lacking anthocyanins are pigmented by betalains but are unable to produce blue hues. By extending the π-system of betalains, we designed a photostable and metal-free blue dye named BeetBlue that did not show toxicity

    更新日期:2020-04-06
  • Scattering of adiabatically aligned molecules by nonresonant optical standing waves
    Sci. Adv. (IF 12.804) Pub Date : 2020-04-03
    Lee Yeong Kim, Byung Gwun Jin, Tae Woo Kim, Ju Hyeon Lee, Bum Suk Zhao

    We study the effect of rotational state–dependent alignment in the scattering of molecules by optical fields. CS2 molecules in their lowest few rotational states are adiabatically aligned and transversely accelerated by a nonresonant optical standing wave. The width of the measured transverse velocity distribution increases to 160 m/s with the field intensity, while its central peak position moves

    更新日期:2020-04-06
  • Metal-free activation of molecular oxygen by covalent triazine frameworks for selective aerobic oxidation
    Sci. Adv. (IF 12.804) Pub Date : 2020-04-03
    Sara Abednatanzi, Parviz Gohari Derakhshandeh, Karen Leus, Henk Vrielinck, Freddy Callens, Johannes Schmidt, Aleksandr Savateev, Pascal Van Der Voort

    Oxygen activation is a critical step in ubiquitous heterogeneous oxidative processes, most prominently in catalysis, electrolysis, and pharmaceutical applications. We present here our findings on metal-free O2 activation on covalent triazine frameworks (CTFs) as an important class of N-rich materials. The O2 activation process was studied for the formation of aldehydes, ketones and imines. A detailed

    更新日期:2020-04-06
  • Lubricated friction around nanodefects
    Sci. Adv. (IF 12.804) Pub Date : 2020-04-03
    Clodomiro Cafolla, William Foster, Kislon Voïtchovsky

    The lubrication properties of nanoconfined liquids underpin countless natural and industrial processes. However, our current understanding of lubricated friction is still limited, especially for nonideal interfaces exhibiting nanoscale chemical and topographical defects. Here, we use atomic force microscopy to explore the equilibrium and dynamical behavior of a model lubricant, squalane, confined between

    更新日期:2020-04-06
  • Quantum biology revisited
    Sci. Adv. (IF 12.804) Pub Date : 2020-04-03
    Jianshu Cao, Richard J. Cogdell, David F. Coker, Hong-Guang Duan, Jürgen Hauer, Ulrich Kleinekathöfer, Thomas L. C. Jansen, Tomáš Mančal, R. J. Dwayne Miller, Jennifer P. Ogilvie, Valentyn I. Prokhorenko, Thomas Renger, Howe-Siang Tan, Roel Tempelaar, Michael Thorwart, Erling Thyrhaug, Sebastian Westenhoff, Donatas Zigmantas

    Photosynthesis is a highly optimized process from which valuable lessons can be learned about the operating principles in nature. Its primary steps involve energy transport operating near theoretical quantum limits in efficiency. Recently, extensive research was motivated by the hypothesis that nature used quantum coherences to direct energy transfer. This body of work, a cornerstone for the field

    更新日期:2020-04-06
  • Symmetry breaking in hydrodynamic forces drives meiotic spindle rotation in mammalian oocytes
    Sci. Adv. (IF 12.804) Pub Date : 2020-04-03
    HaiYang Wang, Yizeng Li, Jing Yang, Xing Duan, Petr Kalab, Sean X. Sun, Rong Li

    Patterned cell divisions require a precisely oriented spindle that segregates chromosomes and determines the cytokinetic plane. In this study, we investigated how the meiotic spindle orients through an obligatory rotation during meiotic division in mouse oocytes. We show that spindle rotation occurs at the completion of chromosome segregation, whereby the separated chromosome clusters each define a

    更新日期:2020-04-06
  • Goldilocks conditions required for earthquakes to trigger basaltic eruptions: Evidence from the 2015 Ambrym eruption
    Sci. Adv. (IF 12.804) Pub Date : 2020-04-03
    I. J. Hamling, G. Kilgour

    Observations indicate a strong correlation between the occurrence of volcanic eruptions and earthquakes. While increased volcanic activity has been observed following both local and distal earthquakes, some of the largest recorded earthquakes aren’t known to have triggered an eruption. Here we investigate whether an eruption and associated dike intrusion at Ambrym volcano was triggered by an Mw 6.4

    更新日期:2020-04-06
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