-
GRK-biased adrenergic agonists for the treatment of type 2 diabetes and obesity Cell (IF 42.5) Pub Date : 2025-06-23 Aikaterini Motso, Benjamin Pelcman, Anastasia Kalinovich, Nour Aldin Kahlous, Muhammad Hamza Bokhari, Nodi Dehvari, Carina Halleskog, Erik Waara, Jasper de Jong, Elizabeth Cheesman, Christine Kallenberg, Gopala Krishna Yakala, Praerona Murad, Erika Wetterdal, Pia Andersson, Sten van Beek, Anna Sandström, Diane Natacha Alleluia, Emanuela Talamonti, Sonia Youhanna, Tore Bengtsson
-
Author Correction: Biogel scavenging slows the sinking of organic particles to the ocean depths Nat. Commun. (IF 15.7) Pub Date : 2025-06-23 Uria Alcolombri, Alon Nissan, Jonasz Słomka, Sam Charlton, Eleonora Secchi, Isobel Short, Kang Soo Lee, François J. Peaudecerf, Dieter A. Baumgartner, Andreas Sichert, Uwe Sauer, Anupam Sengupta, Roman Stocker
Correction to: Nature Communications https://doi.org/10.1038/s41467-025-57982-5, published online 7 April 2025
-
Author Correction: MiR-497∼195 cluster regulates angiogenesis during coupling with osteogenesis by maintaining endothelial Notch and HIF-1α activity Nat. Commun. (IF 15.7) Pub Date : 2025-06-23 Mi Yang, Chang-Jun Li, Xi Sun, Qi Guo, Ye Xiao, Tian Su, Man-Li Tu, Hui Peng, Qiong Lu, Qing Liu, Hong-Bo He, Tie-Jian Jiang, Min-Xiang Lei, Mei Wan, Xu Cao, Xiang-Hang Luo
Correction to: Nature Communications https://doi.org/10.1038/ncomms16003, published online 07 July 2017
-
Author Correction: Detection of single-mode thermal microwave photons using an underdamped Josephson junction Nat. Commun. (IF 15.7) Pub Date : 2025-06-23 A. L. Pankratov, A. V. Gordeeva, A. V. Chiginev, L. S. Revin, A. V. Blagodatkin, N. Crescini, L. S. Kuzmin
Correction to: Nature Communications https://doi.org/10.1038/s41467-025-56040-4, published online 11 April 2025
-
Author Correction: SENP1-mediated NEMO deSUMOylation in adipocytes limits inflammatory responses and type-1 diabetes progression Nat. Commun. (IF 15.7) Pub Date : 2025-06-23 Lan Shao, Huanjiao Jenny Zhou, Haifeng Zhang, Lingfeng Qin, John Hwa, Zhong Yun, Weidong Ji, Wang Min
Correction to: Nature Communications https://doi.org/10.1038/ncomms9917, published online 24 November 2015
-
Cholinergic basal forebrain neurons regulate vascular dynamics and cerebrospinal fluid flux Nat. Commun. (IF 15.7) Pub Date : 2025-06-23 Kai-Hsiang Chuang, Xiaoqing Alice Zhou, Ying Xia, Zengmin Li, Lei Qian, Eamonn Eeles, Grace Ngiam, Jurgen Fripp, Elizabeth J. Coulson
-
Smart and solvent-switchable graphene-based membrane for graded molecular sieving Nat. Commun. (IF 15.7) Pub Date : 2025-06-23 Yuxin Li, Jinping Zhao, Jianduo Zhang, Xinyu Gong, Jin Zhou, Ning Zhang, Yang Su
-
Apical size reduction by macropinocytosis alleviates tissue crowding Nat. Commun. (IF 15.7) Pub Date : 2025-06-23 Enzo Bresteau, Eve E. Suva, Christopher Revell, Osama A. Hassan, Aline Grata, Jennifer Sheridan, Jennifer Mitchell, Constadina Arvanitis, Farida Korobova, Sarah Woolner, Oliver E. Jensen, Brian Mitchell
-
Ice society: looking for life at unlikely altitudes Nature (IF 48.5) Pub Date : 2025-06-23
James Bradley studies the microbes thriving in extremely cold environments.
-
First images from world’s largest digital camera leave astronomers in awe Nature (IF 48.5) Pub Date : 2025-06-23
The new observatory in Chile will map the entire southern sky every 3–4 nights.
-
Medical AI can transform medicine — but only if we carefully track the data it touches Nature (IF 48.5) Pub Date : 2025-06-23 Akhil Vaid
The uncontrolled deployment of machine learning in medicine can distort patient information and sacrifice long-term data reliability for short-term benefits.
-
‘Natural history museums can save the world’: anti-colonialism, conservation and climate change Nature (IF 48.5) Pub Date : 2025-06-23
Zoologist Jack Ashby explains why it’s vital to invest in protecting specimens stored in scientific collections.
-
Obesity drugs show promise treating a new ailment: migraine Nature (IF 48.5) Pub Date : 2025-06-23
Liraglutide, part of the family of blockbuster weight-loss drugs, reduces headaches by half in a small study.
-
Will Gates and other funders save massive public health database at risk from Trump cuts? Nature (IF 48.5) Pub Date : 2025-06-23
UN in talks with governments and funding bodies to save highly-cited, 40-year health data set used by researchers in more than 90 countries.
-
Tardigrade-obsessed: meet the researchers trying to turn water bears into neuroscience models Nature (IF 48.5) Pub Date : 2025-06-23
For water-bear enthusiasts, it’s the creature’s legs that make it stand out.
-
How many PhDs does the world need? Doctoral graduates vastly outnumber jobs in academia Nature (IF 48.5) Pub Date : 2025-06-22
PhD programmes need to better prepare students for careers outside universities, researchers warn.
-
Resolving the three-dimensional interactome of human accelerated regions during human and chimpanzee neurodevelopment Cell (IF 45.5) Pub Date : 2025-06-21 Atreyo Pal, Mark A. Noble, Matheo Morales, Richik Pal, Marybeth Baumgartner, Je Won Yang, Kristina M. Yim, Severin Uebbing, James P. Noonan
(Cell 188, 1504–1523.e1–e10; March 20, 2025)
-
Pr and Pfr structures of plant phytochrome A Nat. Commun. (IF 14.7) Pub Date : 2025-06-21 Soshichiro Nagano, David von Stetten, Kaoling Guan, Peng-Yuan Chen, Chen Song, Thomas Barends, Manfred S. Weiss, Christian G. Feiler, Katerina Dörner, Iñaki de Diego Martinez, Robin Schubert, Johan Bielecki, Lea Brings, Huijong Han, Konstantin Kharitonov, Chan Kim, Marco Kloos, Jayanath C. P. Koliyadu, Faisal H. M. Koua, Ekaterina Round, Abhisakh Sarma, Tokushi Sato, Christina Schmidt, Joana Valerio
-
Early grant success attracts more funding: study of 100,000 applicants hints at why Nature (IF 50.5) Pub Date : 2025-06-20
Largest study of its kind explores the ‘Matthew effect’ in research.
-
Author Correction: Quantum capacities of transducers Nat. Commun. (IF 14.7) Pub Date : 2025-06-20 Chiao-Hsuan Wang, Fangxin Li, Liang Jiang
Correction to: Nature Communications https://doi.org/10.1038/s41467-022-34373-8, published online 05 November 2022
-
Author Correction: Adaptive mechanisms of social and asocial learning in immersive collective foraging Nat. Commun. (IF 14.7) Pub Date : 2025-06-20 Charley M. Wu, Dominik Deffner, Benjamin Kahl, Björn Meder, Mark K. Ho, Ralf H.J.M. Kurvers
Correction to: Nature Communications https://doi.org/10.1038/s41467-025-58365-6, published online 25 April 2025
-
Author Correction: PTEN deficiency reprogrammes human neural stem cells towards a glioblastoma stem cell-like phenotype Nat. Commun. (IF 14.7) Pub Date : 2025-06-20 Shunlei Duan, Guohong Yuan, Xiaomeng Liu, Ruotong Ren, Jingyi Li, Weizhou Zhang, Jun Wu, Xiuling Xu, Lina Fu, Ying Li, Jiping Yang, Weiqi Zhang, Ruijun Bai, Fei Yi, Keiichiro Suzuki, Hua Gao, Concepcion Rodriguez Esteban, Chuanbao Zhang, Juan Carlos Izpisua Belmonte, Zhiguo Chen, Xiaomin Wang, Tao Jiang, Jing Qu, Fuchou Tang, Guang-Hui Liu
Correction to: Nature Communications https://doi.org/10.1038/ncomms10068, published online 03 December 2015
-
Author Correction: ERK and USP5 govern PD-1 homeostasis via deubiquitination to modulate tumor immunotherapy Nat. Commun. (IF 14.7) Pub Date : 2025-06-20 Xiangling Xiao, Jie Shi, Chuan He, Xia Bu, Yishuang Sun, Minling Gao, Bolin Xiang, Wenjun Xiong, Panpan Dai, Qi Mao, Xixin Xing, Yingmeng Yao, Haisheng Yu, Gaoshan Xu, Siqi Li, Yan Ren, Baoxiang Chen, Congqing Jiang, Geng Meng, Yu-Ru Lee, Wenyi Wei, Gordon J. Freeman, Conghua Xie, Jinfang Zhang
Correction to: Nature Communications https://doi.org/10.1038/s41467-023-38605-3, published online 19 May 2023
-
Bringing weak transitions to light Nat. Commun. (IF 14.7) Pub Date : 2025-06-20 Yu He, Xiao-Min Tong, Shuyuan Hu, Gergana D. Borisova, Hao Liang, Maximilian Hartmann, Veit Stooß, Chunhai Lyu, Zoltán Harman, Christoph H. Keitel, Kenneth J. Schafer, Mette B. Gaarde, Christian Ott, Thomas Pfeifer
-
Efficacy of baloxavir marboxil against bovine H5N1 virus in mice Nat. Commun. (IF 14.7) Pub Date : 2025-06-20 Maki Kiso, Ryuta Uraki, Seiya Yamayoshi, Yoshihiro Kawaoka
-
Iron deficiency causes aspartate-sensitive dysfunction in CD8+ T cells Nat. Commun. (IF 14.7) Pub Date : 2025-06-20 Megan R. Teh, Nancy Gudgeon, Joe N. Frost, Linda V. Sinclair, Alastair L. Smith, Christopher L. Millington, Barbara Kronsteiner, Jennie Roberts, Bryan P. Marzullo, Hannah Murray, Alexandra E. Preston, Victoria Stavrou, Jan Rehwinkel, Thomas A. Milne, Daniel A. Tennant, Susanna J. Dunachie, Andrew E. Armitage, Sarah Dimeloe, Hal Drakesmith
-
Quantitative measurement of phenotype dynamics during cancer drug resistance evolution using genetic barcoding Nat. Commun. (IF 14.7) Pub Date : 2025-06-20 Frederick J. H. Whiting, Maximilian Mossner, Calum Gabbutt, Christopher Kimberley, Chris P. Barnes, Ann-Marie Baker, Erika Yara-Romero, Andrea Sottoriva, Richard A. Nichols, Trevor A. Graham
-
In vitro generation of a ureteral organoid from pluripotent stem cells Nat. Commun. (IF 14.7) Pub Date : 2025-06-20 Yutaro Ibi, Koichiro Miike, Tomoko Ohmori, Chen-Leng Cai, Shunsuke Tanigawa, Ryuichi Nishinakamura
-
Halogen abundance evidence for the formation and metasomatism of the primary lunar crust Nat. Commun. (IF 14.7) Pub Date : 2025-06-20 Jie-Jun Jing, Jasper Berndt, Hideharu Kuwahara, Stephan Klemme, Wim van Westrenen
-
This tiny robot moves mini-droplets with ease Nature (IF 50.5) Pub Date : 2025-06-20
Magnetially controlled device can combine or split microlitre-sized droplets.
-
Sensors pinpoint the exact time of a Yellowstone explosion Nature (IF 50.5) Pub Date : 2025-06-20
Data could help to reveal the warning signs of potentially dangerous eruptions caused by liquid groundwater abruptly turning into gas.
-
Stories that are out of this world: Books in brief Nature (IF 50.5) Pub Date : 2025-06-20
Andrew Robinson reviews five of the best science picks.
-
‘Super-healing’ animals inspire human treatments Nature (IF 50.5) Pub Date : 2025-06-20
Studies of the regenerative powers of worms, zebrafish and lizards suggest ways to improve recovery in people.
-
Happy birthday Jaws! How the movie changed shark science Nature (IF 50.5) Pub Date : 2025-06-20
Half a century after its cinematic release, Jaws is still shaping how we view — and protect — the ocean’s top predators.
-
Where is the best place to hold a scientific conference right now? Nature (IF 50.5) Pub Date : 2025-06-20
An immigration crackdown makes the United States less attractive. These locations could steal its crown and make conferences more globally inclusive.
-
Developing astronomers in Africa: ‘We wanted to create a discipline’ Nature (IF 50.5) Pub Date : 2025-06-20
Astronomer Bernie Fanaroff helped to design South Africa’s plan to become a radioastronomy powerhouse — and it started with training the next generation.
-
Bringing men into conversations about parenting in academia Nature (IF 50.5) Pub Date : 2025-06-20
A new campaign by the non-profit group Mothers in Science highlights the challenges and experiences that fathers face, providing actionable steps to becoming a better parent and ally.
-
Africa’s chief diplomat for vaccine manufacturing Nature (IF 50.5) Pub Date : 2025-06-20
Virologist Amadou Sall is the driving force behind a world-class manufacturing hub in Senegal.
-
Daily briefing: Some moths can navigate using starlight Nature (IF 50.5) Pub Date : 2025-06-19
Bogong moths use the stars to find their way during an epic migration across Australia. Plus, the ‘Dragon Man’ fossil belonged to a Denisovan and how our brains might control ageing.
-
AI slashes time to produce gold-standard medical reviews — but sceptics urge caution Nature (IF 48.5) Pub Date : 2025-06-19
Although language models can help to accelerate systematic reviews, a fully automated system is still some way off.
-
Author Correction: Regulatory genomic circuitry of human disease loci by integrative epigenomics Nature (IF 50.5) Pub Date : 2025-06-20 Carles A. Boix, Benjamin T. James, Yongjin P. Park, Wouter Meuleman, Manolis Kellis
Correction to: Nature https://doi.org/10.1038/s41586-020-03145-z Published online 3 February 2021
-
Publisher Correction: The P-loop NTPase RUVBL2 is a conserved clock component across eukaryotes Nature (IF 48.5) Pub Date : 2025-06-19 Meimei Liao, Yanqin Liu, Zhancong Xu, Mingxu Fang, Ziqing Yu, Yufan Cui, Zhengda Sun, Ran Huo, Jieyu Yang, Fusheng Huang, Mingming Liu, Qin Zhou, Xiaocui Song, Hui Han, She Chen, Xiaodong Xu, Ximing Qin, Qun He, Dapeng Ju, Tao Wang, Nirav Thakkar, Paul E. Hardin, Susan S. Golden, Eric Erquan Zhang
Correction to: Nature https://doi.org/10.1038/s41586-025-08797-3 Published online 26 March 2025
-
First ever skull from ‘Denisovan’ reveals what ancient people looked like Nature (IF 48.5) Pub Date : 2025-06-18
Ancient proteins and calcified dental plaque identify heavy-browed fossil from China as a Denisovan.
-
Scalable generation and functional classification of genetic variants in inborn errors of immunity to accelerate clinical diagnosis and treatment Cell (IF 45.5) Pub Date : 2025-06-20 Zachary H. Walsh, Chris J. Frangieh, Neeharika Kothapalli, Jay Levy, Clarissa K. Heck, Johannes C. Melms, Ron S. Gejman, Parin Shah, Jared M. Pollard, Akul Naik, Sarah L. Grauman, Lei Haley Huang, Ashley Lee, Dusan Bogunovic, Joshua D. Milner, Benjamin Izar
-
Regulation of MORC-1 is key to the CSR-1–mediated germline gene licensing mechanism in C. elegans Sci. Adv. (IF 12.5) Pub Date : 2025-06-20 Jessica A. Kirshner, Colette L. Picard, Natasha E. Weiser, Nicita Mehta, Suhua Feng, Victoria N. Murphy, Anna Vakhnovetsky, Amelia F. Alessi, Connie Xiao, Kai Inoki, Sonia El Mouridi, Christian Frøkjær-Jensen, Steven E. Jacobsen, John K. Kim
The Argonaute CSR-1 is essential for germline development in C. elegans . Loss of CSR-1 leads to the down-regulation of thousands of germline-expressed genes, supporting a model in which CSR-1 “licenses” gene expression via a poorly understood mechanism. In contrast, a small subset of genes is up-regulated in csr-1 mutants, including morc-1 , which encodes a conserved GHKL-type ATPase. We show that
-
TGFβ-dependent signaling drives tumor growth and aberrant extracellular matrix dynamics in NF1-associated plexiform neurofibroma Sci. Adv. (IF 12.5) Pub Date : 2025-06-20 Mohannad Abu-Sultanah, Zhuan Zhou, Chunhui Jiang, Dana K. Mitchell, Waylan K. Bessler, Li Jiang, Xiaohong Li, Shaomin Qian, Abbi E. Smith, Henry E. Mang, Emily E. White, Marisa D. Ciesielski, Brooke E. Hickey, Kylee M. Brewster, George E. Sandusky, Andi Masters, Steven P. Angus, D. Wade Clapp, Lu Q. Le, Steven D. Rhodes
Plexiform neurofibromas (PNFs) are benign tumors of the peripheral nervous system that represent a major source of morbidity in neurofibromatosis type 1 (NF1). A substantial proportion of patients do not respond to current therapies or experience intolerable side effects. Transcriptomic characterization of murine and human PNF at bulk and single-cell resolution identified transforming growth factor–β
-
Metabolically driven flows enable exponential growth in macroscopic multicellular yeast Sci. Adv. (IF 12.5) Pub Date : 2025-06-20 Nishant Narayanasamy, Emma Bingham, Tanner Fadero, G. Ozan Bozdag, William C. Ratcliff, Peter Yunker, Shashi Thutupalli
The ecological and evolutionary success of multicellular lineages stems substantially from their increased size relative to unicellular ancestors. However, large size poses biophysical challenges, especially regarding nutrient transport: These constraints are typically overcome through multicellular innovations. Here, we show that an emergent biophysical mechanism—spontaneous fluid flows arising from
-
Instant and secure fixation of e-PTFE medical implants in surgery by designing a bioadhesive interface Sci. Adv. (IF 12.5) Pub Date : 2025-06-20 Yang Gao, Daming Liu, Jing Zhou, Wen Zhang, Danqi Sun, Shuyang Wang, Yipeng Yang, Yuchen Xiang, Yang Zhang, Wei Lei, Tongqing Lu
Expanded polytetrafluoroethylene (e-PTFE) is extensively used in medical implants for its excellent bioinertness. Existing methods to fix e-PTFE implants on host tissues mainly use invasive anchorage such as sutures, spiral tacks, or metal skeletons, which has limitations such as being time-consuming and causing leakage and tissue damage. To overcome these limitations, we introduce a bioadhesive interface
-
Identification of key steps in the evolution of anaerobic methanotrophy in Candidatus Methanovorans (ANME-3) archaea Sci. Adv. (IF 12.5) Pub Date : 2025-06-20 Philip H. Woods, Daan R. Speth, Rafael Laso-Pérez, Daniel R. Utter, S. Emil Ruff, Victoria J. Orphan
Despite their large environmental impact and multiple independent emergences, the processes leading to the evolution of anaerobic methanotrophic archaea (ANME) remain unclear. This work uses comparative metagenomics of a recently evolved but understudied ANME group, “ Candidatus Methanovorans” (ANME-3), to identify evolutionary processes and innovations at work in ANME, which may be obscured in earlier
-
Tuning collagen nonlinear mechanics with interpenetrating networks drives adaptive cellular phenotypes in three dimensions Sci. Adv. (IF 12.5) Pub Date : 2025-06-20 Marco A. Enriquez Martinez, Zhao Wang, Yanina D. Alvarez, Jade E. O’Neill, Robert J. Ju, Petri Turunen, Melanie D. White, Jitendra Mata, Elliot P. Gilbert, Jan Lauko, Alan E. Rowan, Samantha J. Stehbens
In living tissues, collagen networks rarely exist alone because they are embedded within other biological matrices. When combined, collagen networks rigidify via synergistic mechanical interactions and stiffen only with higher mechanical loads. However, how cells respond to the nonlinear elasticity of collagen in hybrid networks remains largely unknown. Here, we demonstrate that when collagen rigidifies
-
Structures of vertebrate R2 retrotransposon complexes during target-primed reverse transcription and after second-strand nicking Sci. Adv. (IF 12.5) Pub Date : 2025-06-20 Akanksha Thawani, Anthony Rodríguez-Vargas, Briana Van Treeck, Nozhat T. Hassan, David L. Adelson, Eva Nogales, Kathleen Collins
R2 retrotransposons are site-specific eukaryotic non–long terminal repeat retrotransposons that copy and paste into gene loci encoding ribosomal RNAs. Recently, we demonstrated that avian A-clade R2 proteins achieve efficient and precise insertion of transgenes into their native safe-harbor loci in human cells. The features of A-clade R2 proteins that support gene insertion are not well characterized
-
Thermodynamic phase transitions of nematic order in magnetic helices Sci. Adv. (IF 12.5) Pub Date : 2025-06-20 Zoey Tumbleson, Sophie A. Morley, Emily Hollingworth, Arnab Singh, Temuujin Bayaraa, Nicolas G. Burdet, Ahmad Us Saleheen, Margaret R. McCarter, David Raftrey, Ronald J. Pandolfi, Vincent Esposito, Georgi L. Dakovski, Franz-Josef Decker, Alexander H. Reid, Tadesse A. Assefa, Peter Fischer, Sinéad M. Griffin, Stephen D. Kevan, Frances Hellman, Joshua J. Turner, Sujoy Roy
A nematic phase lacks translation order but has orientational order. Nematic phases have been discovered in a variety of systems, including liquid crystals, correlated materials, and superconductors. Here, we report on a magnetic nematic phase, where the basis components are composed of magnetic helices. We directly probed the order parameters associated with the magnetic helices using resonant soft
-
Early insight into social network structure predicts climbing the social ladder Sci. Adv. (IF 12.5) Pub Date : 2025-06-20 Isabella C. Aslarus, Jae-Young Son, Alice Xia, Oriel FeldmanHall
While occupying an influential position within one’s social network brings many advantages, it is unknown how certain individuals rise in social prominence. Leveraging a longitudinal dataset that tracks an entirely new network of college freshmen ( N = 187), we test whether “climbing the social ladder” depends on knowing how other people are connected to each other. Those who ultimately come to occupy
-
Global cooling drove diversification and warming caused extinction among Carboniferous-Permian fusuline foraminifera Sci. Adv. (IF 12.5) Pub Date : 2025-06-20 Shu-han Zhang, Ying-ying Zhao, Yu-kun Shi, Qiang Fang, Xiang-dong Wang, Jun-xuan Fan, Yi-chun Zhang, Dong-xun Yuan, Yue Wang, Fei-fei Zhang, Huai-chun Wu, Douglas H. Erwin, Charles R. Marshall, Shu-zhong Shen
The fossil record provides the only direct evidence of changes in biodiversity over time. Patterns in more inclusive taxonomic levels (e.g., families and orders) often become more complex because of interactions between biological traits and environmental conditions across different evolutionary lineages. Using supercomputing and artificial intelligence algorithms, we analyzed a high-resolution global
-
A stress-sensing circuit signals to the central pacemaker to reprogram circadian rhythms Sci. Adv. (IF 12.5) Pub Date : 2025-06-20 Maria E. Yurgel, Claire Gao, John J. O’Malley, Qijun Tang, Noam Yanay, Alison R. Bashford, Jesse J. Zhan, Andrew Lutas, Michael J. Krashes, Haiqing Zhao, Mario A. Penzo, Samer Hattar
The circadian system provides a temporal framework for animals to anticipate environmental events, including threats. However, the effects of stressors on the circadian system remain poorly understood. Here, we demonstrate that, in mice, stressors shift the phase of the central pacemaker, housed in the suprachiasmatic nucleus (SCN), through glutamatergic inputs from the anterior paraventricular nucleus
-
Senataxin and DNA-PKcs redundantly promote non-homologous end joining repair of DNA double strand breaks during V(D)J recombination Sci. Adv. (IF 12.5) Pub Date : 2025-06-20 Bo-Ruei Chen, Thu Pham, Lance D. Reynolds, Nghi Dang, Yanfeng Zhang, Kimberly Manalang, Gabriel Matos-Rodrigues, Jason Romero Neidigk, Andre Nussenzweig, Jessica K. Tyler, Barry P. Sleckman
Nonhomologous end joining (NHEJ) is required for repairing DNA double strand breaks (DSBs) generated by the RAG endonuclease during lymphocyte antigen receptor gene assembly by V(D)J recombination. The ataxia telangiectasia–mutated (ATM) and DNA-dependent protein kinase catalytic subunit (DNA-PKcs) kinases regulate functionally redundant pathways required for NHEJ. Here, we report that loss of the
-
IL-17 links the tumor suppressor LKB1 to gastrointestinal inflammation and polyposis Sci. Adv. (IF 12.5) Pub Date : 2025-06-20 Shelby E. Compton, Lisa M. DeCamp, Brandon M. Oswald, Susan M. Kitchen-Goosen, Kin H. Lau, Robert Fillinger, Michael S. Dahabieh, Alexandra Vander Ark, Connie M. Krawczyk, Russell G. Jones
Mutations in the tumor suppressor liver kinase B1 (LKB1) promote the development of gastrointestinal (GI) polyps of unknown etiology. Here, we identify IL-17 as a novel driver of LKB1-dependent polyp growth. GI tumors from mice bearing heterozygous mutations in Stk11 (which encodes LKB1) display signatures of pathogenic IL-17–producing CD4 + T helper 17 (T H 17) cells. LKB1 constrains T cell inflammatory
-
Artificial selection for adult predation survival affects life history and morphology in guppies ( Poecilia reticulata ) Sci. Adv. (IF 12.5) Pub Date : 2025-06-20 Hannah De Waele, Regina Vega-Trejo, Catarina Vila-Pouca, Jori Noordenbos, Elizabeth Phillips, Bart J. A. Pollux, Alexander Kotrschal
Predation is a major evolutionary driver of life history and morphology. However, whether these traits evolve directly via predation or indirect effects is largely unresolved. We used artificial selection to experimentally test the impact of adult predation on the evolution of life history and morphology in guppies ( Poecilia reticulata ). We found that, compared to control fish, predation-selected
-
Opposite regulation of medullary pain–related projection neuron excitability in acute and chronic pain Sci. Adv. (IF 12.5) Pub Date : 2025-06-20 Ben Title, Enrique Velasco, Nurit Engelmayer, Prudhvi Raj Rayi, Roy Yanai, Shmuel Hart, Ben Katz, Shaya Lev, Yosef Yarom, Alexander M. Binshtok
Pain hypersensitivity is associated with increased activity of peripheral and central neurons along the pain neuroaxis. We show that at the peak of acute inflammatory pain, superficial medullary dorsal horn projection neurons (PNs) that relay nociceptive information to the parabrachial nucleus reduce their intrinsic excitability and, consequently, action potential firing. When pain resolves, the excitability
-
Concentric ice-templating of ultracompressible tough hydrogels with bioinspired circumferentially aligned architecture Sci. Adv. (IF 12.5) Pub Date : 2025-06-20 Wenxi Gu, Shuqi Yang, Dazhe Zhao, Yiwei Zou, Chonghao Chen, Peiqi Niu, Xiangyu Liang, Chi Tat Kwok, Bingpu Zhou, Chunming Wang, Yan Yan Shery Huang, Ji Liu, Iek Man Lei
Materials with circumferentially aligned fibers, such as intervertebral discs and arteries, are abundant in nature but challenging to replicate artificially, despite their mechanical advantages. Although ice-templating can create bioinspired materials, the achievable structures remain limited to simple forms, such as honeycomb, lamellar, and radial structures. Here, we developed a unique ice-templating