Deciphering cellular changes in Alzheimer’s disease (AD) using large cohorts with defined clinical stages is essential for understanding the diverse trajectories of AD progression. In this issue of Cell, five studies harnessed the power of single-nuclei RNA sequencing (snRNA-seq) and single-nuclei ATAC sequencing (snATAC-seq) at unprecedented scale and revealed exciting insights into cell-type-specific

Abstract not available

Ozone recovery is predicted to shift westerly winds, which will reduce the amount of warm water flowing into the Southern Ocean.

Laurent Marivaux works to identify ancient mammals to understand evolutionary history in South America.

During nutrient stress, macroautophagy degrades cellular macromolecules, thereby providing biosynthetic building blocks while simultaneously remodeling the proteome1,2. While machinery responsible for initiation of macroautophagy is well characterized3,4, our understanding of the extent to which individual proteins, protein complexes and organelles are selected for autophagic degradation, and the underlying

Hours of footage of zebrafish embryos let researchers capture and study this key moment in development.

Using a metal–organic framework, researchers reduced the volume of a water-based mixture by 7%.