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Precise and scalable self-organization in mammalian pseudo-embryos Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2024-03-15 Mélody Merle, Leah Friedman, Corinne Chureau, Armin Shoushtarizadeh, Thomas Gregor
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A mechanistic model of primer synthesis from catalytic structures of DNA polymerase α–primase Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2024-03-15 Elwood A. Mullins, Lauren E. Salay, Clarissa L. Durie, Noah P. Bradley, Jane E. Jackman, Melanie D. Ohi, Walter J. Chazin, Brandt F. Eichman
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Structure-guided drug discovery: back to the future Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2024-03-14 Cheryl H. Arrowsmith
Over the past 30 years, the field of structural biology and its associated biological insights have seen amazing progress. In this Comment, I recount several milestones in the field and how we can apply lessons from the past toward an exciting future, especially as it relates to drug discovery.
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Structural basis of human U5 snRNP late biogenesis and recycling Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2024-03-11 Daria Riabov Bassat, Supapat Visanpattanasin, Matthias K. Vorländer, Laura Fin, Alexander W. Phillips, Clemens Plaschka
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Structure of the human 20S U5 snRNP Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2024-03-11 Sarah Schneider, Irina Brandina, Daniel Peter, Sonal Lagad, Angelique Fraudeau, Júlia Portell-Montserrat, Jonas Tholen, Jiangfeng Zhao, Wojciech P. Galej
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Structure of the human outer kinetochore KMN network complex Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2024-03-08 Stanislau Yatskevich, Jing Yang, Dom Bellini, Ziguo Zhang, David Barford
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Structure of the human KMN complex and implications for regulation of its assembly Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2024-03-08 Soumitra Polley, Tobias Raisch, Sabrina Ghetti, Marie Körner, Melina Terbeck, Frauke Gräter, Stefan Raunser, Camilo Aponte-Santamaría, Ingrid R. Vetter, Andrea Musacchio
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Structure and interactions of the endogenous human Commander complex Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2024-03-08 Saara Laulumaa, Esa-Pekka Kumpula, Juha T. Huiskonen, Markku Varjosalo
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Guiding the HBO1 complex function through the JADE subunit Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2024-03-06 Nitika Gaurav, Akinori Kanai, Catherine Lachance, Khan L. Cox, Jiuyang Liu, Adrian T. Grzybowski, Nehmé Saksouk, Brianna J. Klein, Yosuke Komata, Shuhei Asada, Alexander J. Ruthenburg, Michael G. Poirier, Jacques Côté, Akihiko Yokoyama, Tatiana G. Kutateladze
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Regulatory activity is the default DNA state in eukaryotes Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2024-03-06 Ishika Luthra, Cassandra Jensen, Xinyi E. Chen, Asfar Lathif Salaudeen, Abdul Muntakim Rafi, Carl G. de Boer
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Good reasons for structural biology Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2024-03-01 Patrick Cramer
The impressive achievements of structural biology leave us in awe, but also raise the question of whether we can still expect major developments in the field in the future. Before I provide my answer to this question, let me briefly reflect on the major advances in structural biology over the past three decades. Thirty years ago, in 1994, the journal Nature Structural Biology (renamed Nature Structural
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The open gate of the AMPA receptor forms a Ca2+ binding site critical in regulating ion transport Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2024-02-26 Terunaga Nakagawa, Xin-tong Wang, Federico J. Miguez-Cabello, Derek Bowie
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Nucleosome-bound NR5A2 structure reveals pioneer factor mechanism by DNA minor groove anchor competition Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2024-02-26 Wataru Kobayashi, Anna H. Sappler, Daniel Bollschweiler, Maximilian Kümmecke, Jérôme Basquin, Eda Nur Arslantas, Siwat Ruangroengkulrith, Renate Hornberger, Karl Duderstadt, Kikuë Tachibana
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The CNK–HYP scaffolding complex promotes RAF activation by enhancing KSR–MEK interaction Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2024-02-22 Pierre Maisonneuve, Malha Sahmi, Fanny Bergeron-Labrecque, Xianjie Iris Ma, Juliette Queguiner, Geneviève Arseneault, Martin Lefrançois, Igor Kurinov, Rémi Fronzes, Frank Sicheri, Marc Therrien
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Cryo-EM structure of human sphingomyelin synthase and its mechanistic implications for sphingomyelin synthesis Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2024-02-22 Kexin Hu, Qing Zhang, Yang Chen, Jintong Yang, Ying Xia, Bing Rao, Shaobai Li, Yafeng Shen, Mi Cao, Hongliang Lu, An Qin, Xian-Cheng Jiang, Deqiang Yao, Jie Zhao, Lu Zhou, Yu Cao
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Deadenylation kinetics of mixed poly(A) tails at single-nucleotide resolution Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2024-02-19 Young-suk Lee, Yevgen Levdansky, Yoonseok Jung, V. Narry Kim, Eugene Valkov
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Protein-intrinsic properties and context-dependent effects regulate pioneer factor binding and function Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2024-02-16 Tyler J. Gibson, Elizabeth D. Larson, Melissa M. Harrison
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Turning vaccine design on its head Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2024-02-16 Katarzyna Ciazynska
Different subtypes of influenza fusion protein hemagglutinin are included in the vaccine cocktail. However, the immune response is often produced against the immunodominant, variable region of hemagglutinin, while it is of interest to develop broadly neutralizing antibodies against the stem region, which is conserved. Eliciting an immune response against a conserved region promises broader protection
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Breaking the K48-chain: linking ubiquitin beyond protein degradation Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2024-02-16 Sanim Rahman, Cynthia Wolberger
The discovery of ubiquitin conjugation to lysines and the role of K48-linked polyubiquitin in targeting substrates for proteasomal degradation was followed by revelation of non-degradative roles of ubiquitination and, more recently, of non-canonical covalent ubiquitin linkages. Here we summarize findings of the ever-expanding array of ubiquitin signals and their biological roles.
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Towards an improved understanding of ubiquitylation Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2024-02-16
First discovered more than five decades ago, protein ubiquitylation has proven to be an omnipresent post-translational modification regulating virtually every eukaryotic cellular process. With novel clinical applications and recent studies demonstrating ubiquitylation of biomolecules other than proteins, the interest in ubiquitin will not waver any time soon.
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Ubiquitin in autophagy and non-protein ubiquitination Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2024-02-16 Noboru Mizushima
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Chemical rewiring of ubiquitination by degraders and their selectivity routes Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2024-02-16 Rory Whelan, Cristina Mayor-Ruiz
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Just how big is the ubiquitin system? Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2024-02-12 Bernhard C. Lechtenberg, David Komander
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Single-nucleoid architecture reveals heterogeneous packaging of mitochondrial DNA Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2024-02-12 R. Stefan Isaac, Thomas W. Tullius, Katja G. Hansen, Danilo Dubocanin, Mary Couvillion, Andrew B. Stergachis, L. Stirling Churchman
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Protein destabilization underlies pathogenic missense mutations in ARID1B Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2024-02-12 Fanny Mermet-Meillon, Samuele Mercan, Beatrice Bauer-Probst, Cyril Allard, Melusine Bleu, Keith Calkins, Judith Knehr, Marc Altorfer, Ulrike Naumann, Kathleen Sprouffske, Louise Barys, Fabian Sesterhenn, Giorgio G. Galli
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Structural basis for excitatory neuropeptide signaling Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2024-02-09 Valeria Kalienkova, Mowgli Dandamudi, Cristina Paulino, Timothy Lynagh
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Dynamic molecular architecture and substrate recruitment of cullin3–RING E3 ligase CRL3KBTBD2 Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2024-02-08 Yuxia Hu, Zhao Zhang, Qiyu Mao, Xiang Zhang, Aihua Hao, Yu Xun, Yeda Wang, Lin Han, Wuqiang Zhan, Qianying Liu, Yue Yin, Chao Peng, Eva Marie Y. Moresco, Zhenguo Chen, Bruce Beutler, Lei Sun
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Constitutive activation mechanism of a class C GPCR Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2024-02-08 Jinwoo Shin, Junhyeon Park, Jieun Jeong, Jordy Homing Lam, Xingyu Qiu, Di Wu, Kuglae Kim, Joo-Youn Lee, Carol V. Robinson, Jaekyung Hyun, Vsevolod Katritch, Kwang Pyo Kim, Yunje Cho
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Structural mechanisms of autoinhibition and substrate recognition by the ubiquitin ligase HACE1 Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2024-02-08 Jonas Düring, Madita Wolter, Julia J. Toplak, Camilo Torres, Olexandr Dybkov, Thornton J. Fokkens, Katherine E. Bohnsack, Henning Urlaub, Wieland Steinchen, Christian Dienemann, Sonja Lorenz
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Activation of CBASS Cap5 endonuclease immune effector by cyclic nucleotides Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2024-02-06 Olga Rechkoblit, Daniela Sciaky, Dale F. Kreitler, Angeliki Buku, Jithesh Kottur, Aneel K. Aggarwal
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Mechanism of millisecond Lys48-linked poly-ubiquitin chain formation by cullin-RING ligases Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2024-02-07 Joanna Liwocha, Jerry Li, Nicholas Purser, Chutima Rattanasopa, Samuel Maiwald, David T. Krist, Daniel C. Scott, Barbara Steigenberger, J. Rajan Prabu, Brenda A. Schulman, Gary Kleiger
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GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2024-02-07 Nicholas Hoppe, Simone Harrison, Sun-Hee Hwang, Ziwei Chen, Masha Karelina, Ishan Deshpande, Carl-Mikael Suomivuori, Vivek R. Palicharla, Samuel P. Berry, Philipp Tschaikner, Dominik Regele, Douglas F. Covey, Eduard Stefan, Debora S. Marks, Jeremy F. Reiter, Ron O. Dror, Alex S. Evers, Saikat Mukhopadhyay, Aashish Manglik
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Structural insights into the specific recognition and transfer of ISG15 Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2024-02-06 Irene Serrano
ISG15 is composed of two Ub-like domains separated by a flexible linker. The N- and C-terminal domains of ISG15 share some sequence similarity, and much more structural similarity, with Ub. Despite these commonalities between Ub and ISG15, ISG15 is exclusively activated by UBA7. This raises the question, what are the molecular mechanisms of this specific ISG15 activation and UBA7–UBE2L6–ISG15 interaction
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A quantitative and site-specific atlas of the citrullinome reveals widespread existence of citrullination and insights into PADI4 substrates Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2024-02-06 Alexandra S. Rebak, Ivo A. Hendriks, Jonas D. Elsborg, Sara C. Buch-Larsen, Claus H. Nielsen, Lene Terslev, Rebecca Kirsch, Dres Damgaard, Nadezhda T. Doncheva, Caroline Lennartsson, Martin Rykær, Lars J. Jensen, Maria A. Christophorou, Michael L. Nielsen
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Multi-modal cryo-EM reveals trimers of protein A10 to form the palisade layer in poxvirus cores Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2024-02-05 Julia Datler, Jesse M. Hansen, Andreas Thader, Alois Schlögl, Lukas W. Bauer, Victor-Valentin Hodirnau, Florian K. M. Schur
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The palisade layer of the poxvirus core is composed of flexible A10 trimers Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2024-02-05 Jiasui Liu, Simon Corroyer-Dulmont, Vojtěch Pražák, Iskander Khusainov, Karola Bahrami, Sonja Welsch, Daven Vasishtan, Agnieszka Obarska-Kosińska, Sigurdur R. Thorkelsson, Kay Grünewald, Emmanuelle R. J. Quemin, Beata Turoňová, Jacomina Krijnse Locker
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A novel class of inhibitors that disrupts the stability of integrin heterodimers identified by CRISPR-tiling-instructed genetic screens Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2024-02-05 Nicole M. Mattson, Anthony K. N. Chan, Kazuya Miyashita, Elizaveta Mukhaleva, Wen-Han Chang, Lu Yang, Ning Ma, Yingyu Wang, Sheela Pangeni Pokharel, Mingli Li, Qiao Liu, Xiaobao Xu, Renee Chen, Priyanka Singh, Leisi Zhang, Zeinab Elsayed, Bryan Chen, Denise Keen, Patrick Pirrotte, Steven. T. Rosen, Jianjun Chen, Mark A. LaBarge, John E. Shively, Nagarajan Vaidehi, Russell C. Rockne, Mingye Feng, Chun-Wei
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Conformational ensemble of yeast ATP synthase at low pH reveals unique intermediates and plasticity in F1–Fo coupling Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2024-02-05 Stuti Sharma, Min Luo, Hiral Patel, David M. Mueller, Maofu Liao
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Structural basis for RNA polymerase II ubiquitylation and inactivation in transcription-coupled repair Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2024-02-05 Goran Kokic, George Yakoub, Diana van den Heuvel, Annelotte P. Wondergem, Paula J. van der Meer, Yana van der Weegen, Aleksandar Chernev, Isaac Fianu, Thornton J. Fokkens, Sonja Lorenz, Henning Urlaub, Patrick Cramer, Martijn S. Luijsterburg
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Tropomyosin 1-I/C coordinates kinesin-1 and dynein motors during oskar mRNA transport Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2024-01-31 Simone Heber, Mark A. McClintock, Bernd Simon, Eve Mehtab, Karine Lapouge, Janosch Hennig, Simon L. Bullock, Anne Ephrussi
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Variant in the synaptonemal complex protein SYCE2 associates with pregnancy loss through effect on recombination Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2024-01-29 Valgerdur Steinthorsdottir, Bjarni V. Halldorsson, Hakon Jonsson, Gunnar Palsson, Asmundur Oddsson, David Westergaard, Gudny A. Arnadottir, Lilja Stefansdottir, Karina Banasik, M. Sean Esplin, Thomas Folkmann Hansen, Søren Brunak, Mette Nyegaard, Sisse Rye Ostrowski, Ole Birger Vesterager Pedersen, Christian Erikstrup, Gudmar Thorleifsson, Lincoln D. Nadauld, Asgeir Haraldsson, Thora Steingrimsdottir
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Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23 Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2024-01-29 Yehudi Bloch, Jan Felix, Romain Merceron, Mathias Provost, Royan Alipour Symakani, Robin De Backer, Elisabeth Lambert, Ahmad R. Mehdipour, Savvas N. Savvides
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The structure of a human translation initiation complex reveals two independent roles for the helicase eIF4A Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2024-01-29 Jailson Brito Querido, Masaaki Sokabe, Irene Díaz-López, Yuliya Gordiyenko, Christopher S. Fraser, V. Ramakrishnan
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NSMB’s 30th anniversary: shining a light on the invisible Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2024-01-22 Pedro Rebelo-Guiomar
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Structural basis of pH-dependent activation in a CLC transporter Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2024-01-26 Eva Fortea, Sangyun Lee, Rahul Chadda, Yiorgos Argyros, Priyanka Sandal, Robyn Mahoney-Kruszka, Didar Ciftici, Maria E. Falzone, Gerard Huysmans, Janice L. Robertson, Olga Boudker, Alessio Accardi
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Cortactin stabilizes actin branches by bridging activated Arp2/3 to its nucleated actin filament Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2024-01-24 Tianyang Liu, Luyan Cao, Miroslav Mladenov, Antoine Jegou, Michael Way, Carolyn A. Moores
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Structural mechanism of synergistic targeting of the CX3CR1 nucleosome by PU.1 and C/EBPα Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2024-01-24 Tengfei Lian, Ruifang Guan, Bing-Rui Zhou, Yawen Bai
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Communities in structural biology Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2024-01-22 Martyn David Winn
Collaboration is key to modern science, with major advances using multiple complementary approaches and dependent on sophisticated infrastructure. Yet science is also highly personal, as each person carves out a reputation and career. How does this work out in reality, and how can communities be built to benefit science and scientists?
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Thinking outside the chromosome: epigenetic mechanisms in non-canonical chromatin species Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2024-01-22 Albert S. Agustinus, Yael David
Here we investigate the role of epigenetics in the formation, transcription regulation, maintenance and termination of several non-canonical chromatin structures. Using two examples, we demonstrate how studying non-canonical structures may reveal underlying mechanisms with implications for disease and propose intriguing epigenetic avenues for further exploration.
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Structural biology in the Anthropocene epoch Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2024-01-22 Peter D. Mabbitt
Like many biologists, I was drawn to structural biology by the beauty of nature. Curing disease and solving world hunger may fuel grant applications, but these noble ambitions rarely spark curiosity like the undeniable marvels of the natural world. The fact that we literally see the world through the ordered lattice of a crystalline protein lens1, and that fluorescent proteins not only absorb and emit
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Celebrating Nature Structural & Molecular Biology’s 30th anniversary Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2024-01-22
January 2024 marks 30 years since we published our first volume. Throughout the upcoming year, we will be celebrating this milestone, reflecting on the road covered and looking toward the future — with the help of our readers.
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Lineage regulators TFAP2C and NR5A2 function as bipotency activators in totipotent embryos Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2024-01-19 Lijia Li, Fangnong Lai, Ling Liu, Xukun Lu, Xiaoyu Hu, Bofeng Liu, Zili Lin, Qiang Fan, Feng Kong, Qianhua Xu, Wei Xie
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The histone chaperone SPT2 regulates chromatin structure and function in Metazoa Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2024-01-18 Giulia Saredi, Francesco N. Carelli, Stéphane G. M. Rolland, Giulia Furlan, Sandra Piquet, Alex Appert, Luis Sanchez-Pulido, Jonathan L. Price, Pablo Alcon, Lisa Lampersberger, Anne-Cécile Déclais, Navin B. Ramakrishna, Rachel Toth, Thomas Macartney, Constance Alabert, Chris P. Ponting, Sophie E. Polo, Eric A. Miska, Anton Gartner, Julie Ahringer, John Rouse
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Structural basis of hepatitis B virus receptor binding Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2024-01-17 Jinta Asami, Jae-Hyun Park, Yayoi Nomura, Chisa Kobayashi, Junki Mifune, Naito Ishimoto, Tomoko Uemura, Kehong Liu, Yumi Sato, Zhikuan Zhang, Masamichi Muramatsu, Takaji Wakita, David Drew, So Iwata, Toshiyuki Shimizu, Koichi Watashi, Sam-Yong Park, Norimichi Nomura, Umeharu Ohto
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Structural basis of prostaglandin efflux by MRP4 Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2024-01-12 Sergei Pourmal, Evan Green, Ruchika Bajaj, Ilan E. Chemmama, Giselle M. Knudsen, Meghna Gupta, Andrej Sali, Yifan Cheng, Charles S. Craik, Deanna L. Kroetz, Robert M. Stroud
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Keep quiet: the HUSH complex in transcriptional silencing and disease Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2024-01-12 Iris Müller, Kristian Helin
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Structural insights into branch site proofreading by human spliceosome Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2024-01-09 Xiaofeng Zhang, Xiechao Zhan, Tong Bian, Fenghua Yang, Pan Li, Yichen Lu, Zhihan Xing, Rongyan Fan, Qiangfeng Cliff Zhang, Yigong Shi
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Mitotic bookmarking redundancy by nuclear receptors in pluripotent cells Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2024-01-09 Almira Chervova, Amandine Molliex, H. Irem Baymaz, Rémi-Xavier Coux, Thaleia Papadopoulou, Florian Mueller, Eslande Hercul, David Fournier, Agnès Dubois, Nicolas Gaiani, Petra Beli, Nicola Festuccia, Pablo Navarro
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Structure of a membrane tethering complex incorporating multiple SNAREs Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2024-01-09 Kevin A. DAmico, Abigail E. Stanton, Jaden D. Shirkey, Sophie M. Travis, Philip D. Jeffrey, Frederick M. Hughson
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Thirty years of structural changes Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2024-01-08 Andrea Musacchio
The concluding statement of Watson and Crick’s historic paper on the structure of DNA1 enshrines a key tenet of molecular mechanistic cell biology: “… the specific pairing we have postulated immediately suggests a possible copying mechanism for the genetic material”. Function — heredity in this case — is embedded in the redundant sequence information of the two strands of DNA. Although not always expressed