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Transcription start site choice diversifies mRNA isoforms and defines cancer cell behavior Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2023-11-27
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POLQ to the rescue for double-strand break repair during mitosis Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2023-11-23 Marcel A. T. M. van Vugt, Marcel Tijsterman
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Intra-promoter switch of transcription initiation sites in proliferation signaling-dependent RNA metabolism Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2023-11-23 Joseph W. Wragg, Paige-Louise White, Yavor Hadzhiev, Kasun Wanigasooriya, Agata Stodolna, Louise Tee, Joao D. Barros-Silva, Andrew D. Beggs, Ferenc Müller
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AGO2 localizes to the nucleus in quiescence and represses transposon expression Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2023-11-22
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AGO2 silences mobile transposons in the nucleus of quiescent cells Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2023-11-20 Laura Sala, Manish Kumar, Mahendra Prajapat, Srividya Chandrasekhar, Rachel L. Cosby, Gaspare La Rocca, Todd S. Macfarlan, Parirokh Awasthi, Raj Chari, Michael Kruhlak, Joana A. Vidigal
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Multidomain interactions and ring opening of the p97 ATPase by the UBXD1 adapter Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2023-11-16
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FSP1 inhibition: pick your pocket Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2023-11-13 Christina M. Bebber, Silvia von Karstedt
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OAT1 structures reveal insights into drug transport in the kidney Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2023-11-13 Leifu Chang
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Start codon-associated ribosomal frameshifting mediates nutrient stress adaptation Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2023-11-13 Yuanhui Mao, Longfei Jia, Leiming Dong, Xin Erica Shu, Shu-Bing Qian
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Integrated chemical and genetic screens unveil FSP1 mechanisms of ferroptosis regulation Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2023-11-13 Toshitaka Nakamura, Eikan Mishima, Naoya Yamada, André Santos Dias Mourão, Dietrich Trümbach, Sebastian Doll, Jonas Wanninger, Elena Lytton, Peter Sennhenn, Thamara Nishida Xavier da Silva, José Pedro Friedmann Angeli, Michael Sattler, Bettina Proneth, Marcus Conrad
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EMC rectifies the topology of multipass membrane proteins Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2023-11-13 Haoxi Wu, Luka Smalinskaitė, Ramanujan S. Hegde
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MOF acetylates COX17 to preserve functional mitochondria: a KAT with two lives Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2023-11-09 Dimitris Typas
Writing in Nature Metabolism, Guhathakurta et al. provide pertinent functional and mechanistic insight about this elusive role. Initially using inducible knockouts in primary mouse embryonic fibroblasts (MEFs), the authors show that loss of MOF or KANSL2 leads to aberrant cellular respiration, excessive mitochondrial reactive oxygen species (mtROS) and reduced mitochondrial potential, concomitantly
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Cryo-EM reveals how Hsp90 and FKBP immunophilins co-regulate the glucocorticoid receptor Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2023-11-09 Chari M. Noddings, Jill L. Johnson, David A. Agard
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The p97/VCP adaptor UBXD1 drives AAA+ remodeling and ring opening through multi-domain tethered interactions Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2023-11-09 Julian R. Braxton, Chad R. Altobelli, Maxwell R. Tucker, Eric Tse, Aye C. Thwin, Michelle R. Arkin, Daniel R. Southworth
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Large-scale, in-cell photocrosslinking at single-residue resolution reveals the molecular basis for glucocorticoid receptor regulation by immunophilins Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2023-11-09 Asat Baischew, Sarah Engel, Martha C. Taubert, Thomas M. Geiger, Felix Hausch
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CRISPR–Cas9-based functional interrogation of unconventional translatome reveals human cancer dependency on cryptic non-canonical open reading frames Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2023-11-06 Caishang Zheng, Yanjun Wei, Peng Zhang, Kangyu Lin, Dandan He, Hongqi Teng, Ganiraju Manyam, Zhao Zhang, Wen Liu, Hye Rin Lindsay Lee, Ximing Tang, Wei He, Nelufa Islam, Antrix Jain, Yulun Chiu, Shaolong Cao, Yarui Diao, Sherita Meyer-Gauen, Magnus Höök, Anna Malovannaya, Wenbo Li, Ming Hu, Wenyi Wang, Han Xu, Scott Kopetz, Yiwen Chen
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Structure of the transcribing RNA polymerase II–Elongin complex Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2023-11-06 Ying Chen, Goran Kokic, Christian Dienemann, Olexandr Dybkov, Henning Urlaub, Patrick Cramer
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The molecular basis of drug selectivity for α5 subunit-containing GABAA receptors Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2023-10-30 Vikram Babu Kasaragod, Tomas Malinauskas, Ayla A. Wahid, Judith Lengyel, Frederic Knoflach, Steven W. Hardwick, Charlotte F. Jones, Wan-Na Chen, Xavier Lucas, Kamel El Omari, Dimitri Y. Chirgadze, A. Radu Aricescu, Giuseppe Cecere, Maria-Clemencia Hernandez, Paul S. Miller
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Mechanism of histone H2B monoubiquitination by Bre1 Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2023-10-23 Fan Zhao, Chad W. Hicks, Cynthia Wolberger
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Mechanical disengagement of the cohesin ring Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2023-10-23 Martina Richeldi, Georgii Pobegalov, Torahiko L. Higashi, Karolina Gmurczyk, Frank Uhlmann, Maxim I. Molodtsov
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Molecular mechanism of glutaminase activation through filamentation and the role of filaments in mitophagy protection Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2023-10-19 Douglas Adamoski, Marilia Meira Dias, Jose Edwin Neciosup Quesñay, Zhengyi Yang, Ievgeniia Zagoriy, Anna M. Steyer, Camila Tanimoto Rodrigues, Alliny Cristiny da Silva Bastos, Bianca Novaes da Silva, Renna Karoline Eloi Costa, Flávia Mayumi Odahara de Abreu, Zeyaul Islam, Alexandre Cassago, Marin Gerard van Heel, Sílvio Roberto Consonni, Simone Mattei, Julia Mahamid, Rodrigo Villares Portugal, Andre
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Structure of LRRK1 and mechanisms of autoinhibition and activation Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2023-10-19 Janice M. Reimer, Andrea M. Dickey, Yu Xuan Lin, Robert G. Abrisch, Sebastian Mathea, Deep Chatterjee, Elizabeth J. Fay, Stefan Knapp, Matthew D. Daugherty, Samara L. Reck-Peterson, Andres E. Leschziner
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Surviving under stress conditions Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2023-10-16 Chiara Francavilla
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The regulatory landscape of the yeast phosphoproteome Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2023-10-16 Mario Leutert, Anthony S. Barente, Noelle K. Fukuda, Ricard A. Rodriguez-Mias, Judit Villén
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The modes of action of ion-channel-targeting neurotoxic insecticides: lessons from structural biology Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2023-10-16 Tobias Raisch, Stefan Raunser
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The substrate and inhibitor binding mechanism of polyspecific transporter OAT1 revealed by high-resolution cryo-EM Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2023-10-16 Tongyi Dou, Tengfei Lian, Shi Shu, Yi He, Jiansen Jiang
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Shifted PAMs generate DNA overhangs and enhance SpCas9 post-catalytic complex dissociation Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2023-10-12 Jinglong Wang, Julien Le Gall, Richard L. Frock, Terence R. Strick
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TDP-43 folds shape disease Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2023-10-09 Katarzyna Ciazynska
TDP-43 is a conserved RNA-binding protein. In healthy cells, TDP-43 resides mainly in the nucleus where it plays a role in RNA processing, but it can be shuttled to the cytoplasm as well. In disease, full-length and truncated TDP-43 is post-translationally modified and forms granulofilamentous assemblies. The existence of rare pathogenic missense mutations in the TDP-43 encoding gene in ALS and FTLD
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Structural insights into an intracellular biased agonist for GPCRs Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2023-10-06 Neeraj Soni, Tarumoy Das, Mithu Baidya
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Structure of histone deacetylase complex Rpd3S bound to nucleosome Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2023-10-05 Wulong Li, Hengjun Cui, Zhimin Lu, Haibo Wang
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Elongation roadblocks mediated by dCas9 across human genes modulate transcription and nascent RNA processing Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2023-10-02 Inna Zukher, Gwendal Dujardin, Rui Sousa-Luís, Nick J. Proudfoot
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The great escape — how inorganic phosphate is released from actin filaments Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2023-09-29
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Cryo-EM structures of Myomaker reveal a molecular basis for myoblast fusion Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2023-09-28 Tao Long, Yichi Zhang, Linda Donnelly, Hui Li, Yu-Chung Pien, Ning Liu, Eric N. Olson, Xiaochun Li
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Structure and activation of the RING E3 ubiquitin ligase TRIM72 on the membrane Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2023-09-28 Si Hoon Park, Juhyun Han, Byung-Cheon Jeong, Ju Han Song, Se Hwan Jang, Hyeongseop Jeong, Bong Heon Kim, Young-Gyu Ko, Zee-Yong Park, Kyung Eun Lee, Jaekyung Hyun, Hyun Kyu Song
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Live-cell three-dimensional single-molecule tracking reveals modulation of enhancer dynamics by NuRD Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2023-09-28 S. Basu, O. Shukron, D. Hall, P. Parutto, A. Ponjavic, D. Shah, W. Boucher, D. Lando, W. Zhang, N. Reynolds, L. H. Sober, A. Jartseva, R. Ragheb, X. Ma, J. Cramard, R. Floyd, J. Balmer, T. A. Drury, A. R. Carr, L.-M. Needham, A. Aubert, G. Communie, K. Gor, M. Steindel, L. Morey, E. Blanco, T. Bartke, L. Di Croce, I. Berger, C. Schaffitzel, S. F. Lee, T. J. Stevens, D. Klenerman, B. D. Hendrich, D
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Hallucination of closed repeat proteins containing central pockets Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2023-09-28 Linna An, Derrick R. Hicks, Dmitri Zorine, Justas Dauparas, Basile I. M. Wicky, Lukas F. Milles, Alexis Courbet, Asim K. Bera, Hannah Nguyen, Alex Kang, Lauren Carter, David Baker
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Molecular mechanisms of inorganic-phosphate release from the core and barbed end of actin filaments Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2023-09-25 Wout Oosterheert, Florian E. C. Blanc, Ankit Roy, Alexander Belyy, Micaela Boiero Sanders, Oliver Hofnagel, Gerhard Hummer, Peter Bieling, Stefan Raunser
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PARylated PDHE1α generates acetyl-CoA for local chromatin acetylation and DNA damage repair Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2023-09-21 Jun Zhang, Feng Chen, Yuan Tian, Wenchao Xu, Qian Zhu, Zhenhai Li, Lingyu Qiu, Xiaopeng Lu, Bin Peng, Xiangyu Liu, Haiyun Gan, Baohua Liu, Xingzhi Xu, Wei-Guo Zhu
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Time-resolved cryo-EM (TR-EM) analysis of substrate polyubiquitination by the RING E3 anaphase-promoting complex/cyclosome (APC/C) Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2023-09-21 Tatyana Bodrug, Kaeli A. Welsh, Derek L. Bolhuis, Ethan Paulаkonis, Raquel C. Martinez-Chacin, Bei Liu, Nicholas Pinkin, Thomas Bonacci, Liying Cui, Pengning Xu, Olivia Roscow, Sascha Josef Amann, Irina Grishkovskaya, Michael J. Emanuele, Joseph S. Harrison, Joshua P. Steimel, Klaus M. Hahn, Wei Zhang, Ellen D. Zhong, David Haselbach, Nicholas G. Brown
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Aberrant gene activation in synovial sarcoma relies on SSX specificity and increased PRC1.1 stability Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2023-09-21 Nezha S. Benabdallah, Vineet Dalal, R. Wilder Scott, Fady Marcous, Afroditi Sotiriou, Felix K. F. Kommoss, Anastasija Pejkovska, Ludmila Gaspar, Lena Wagner, Francisco J. Sánchez-Rivera, Monica Ta, Shelby Thornton, Torsten O. Nielsen, T. Michael Underhill, Ana Banito
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m6A governs length-dependent enrichment of mRNAs in stress granules Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2023-09-14 Ryan J. Ries, Brian F. Pickering, Hui Xian Poh, Sim Namkoong, Samie R. Jaffrey
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Conformational coupling of redox-driven Na+-translocation in Vibrio cholerae NADH:quinone oxidoreductase Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2023-09-14 Jann-Louis Hau, Susann Kaltwasser, Valentin Muras, Marco S. Casutt, Georg Vohl, Björn Claußen, Wojtek Steffen, Alexander Leitner, Eckhard Bill, George E. Cutsail, Serena DeBeer, Janet Vonck, Julia Steuber, Günter Fritz
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Structure reveals why genome folding is necessary for site-specific integration of foreign DNA into CRISPR arrays Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2023-09-14 Andrew Santiago-Frangos, William S. Henriques, Tanner Wiegand, Colin C. Gauvin, Murat Buyukyoruk, Ava B. Graham, Royce A. Wilkinson, Lenny Triem, Kasahun Neselu, Edward T. Eng, Gabriel C. Lander, Blake Wiedenheft
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Architects of the membrane: structures of eukaryotic choline phosphotransferase 1 and choline/ethanolamine phosphotransferase 1 Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2023-09-11 Rahul Raina, Anirban Banerjee
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Molecular pathway of mitochondrial preprotein import through the TOM–TIM23 supercomplex Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2023-09-11 Xueyin Zhou, Yuqi Yang, Guopeng Wang, Shanshan Wang, Dongjie Sun, Xiaomin Ou, Yuke Lian, Long Li
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New pieces for the Lis1–dynein puzzle Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2023-09-12 Clinton K. Lau
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Natural selection finds a way, even under heavy constraints Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2023-09-11 Dimitris Typas
Writing in Nature, Moger-Reischer et al.1 address this question by studying minimal cells from the Mycoplasma mycoides JCVI-syn3B strain. First, they test how reducing protein coding genes from the approximately 900 found in the original strain (non-minimal cell) to less than 500 in the streamlined strain (minimal cell) affects mutation input. Surprisingly, both strains display similar mutation rates
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Our 30th anniversary is approaching. We want to hear from you Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2023-09-11
In January 2024, Nature Structural & Molecular Biology (NSMB) will celebrate the 30th anniversary of publishing its first issue . Though initially launched as Nature Structural Biology in 1994, the journal has since expanded its scope to include all research into the molecular underpinnings of life, with the vision that the broadest insight can be gleaned through a suite of complimentary approaches
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Dynamics of the DYNLL1–MRE11 complex regulate DNA end resection and recruitment of Shieldin to DSBs Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2023-09-11 Michelle L. Swift, Rui Zhou, Aleem Syed, Lisa A. Moreau, Bartłomiej Tomasik, John A. Tainer, Panagiotis A. Konstantinopoulos, Alan D. D’Andrea, Yizhou Joseph He, Dipanjan Chowdhury
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Nucleosome density shapes kilobase-scale regulation by a mammalian chromatin remodeler Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2023-09-11 Nour J. Abdulhay, Laura J. Hsieh, Colin P. McNally, Megan S. Ostrowski, Camille M. Moore, Mythili Ketavarapu, Sivakanthan Kasinathan, Arjun S. Nanda, Ke Wu, Un Seng Chio, Ziling Zhou, Hani Goodarzi, Geeta J. Narlikar, Vijay Ramani
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Transcriptional repression upon S phase entry protects genome integrity in pluripotent cells Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2023-09-11 Deniz Gökbuget, Kayla Lenshoek, Ryan M. Boileau, Jonathan Bayerl, Hector Huang, Arun P. Wiita, Diana J. Laird, Robert Blelloch
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Functional epigenomics: chromatin complexity untangled Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2023-09-08 Ricardo Mack, Or Gozani
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Regulation with cell size ensures mitochondrial DNA homeostasis during cell growth Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2023-09-07 Anika Seel, Francesco Padovani, Moritz Mayer, Alissa Finster, Daniela Bureik, Felix Thoma, Christof Osman, Till Klecker, Kurt M. Schmoller
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Mammalian CCR4–NOT binds and ubiquitinates 80S ribosomes to enforce translational stalling Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2023-09-05
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CRISPR–ChIP reveals selective regulation of H3K79me2 by Menin in MLL leukemia Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2023-09-07 Omer Gilan, Laure Talarmain, Charles C. Bell, Daniel Neville, Kathy Knezevic, Daniel T. Ferguson, Marion Boudes, Yih-Chih Chan, Chen Davidovich, Enid Y. N. Lam, Mark A. Dawson
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Substrate binding and inhibition of the anion exchanger 1 transporter Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2023-09-07 Michael J. Capper, Shifan Yang, Alexander C. Stone, Sezen Vatansever, Gregory Zilberg, Yamuna Kalyani Mathiharan, Raul Habib, Keino Hutchinson, Yihan Zhao, Avner Schlessinger, Mihaly Mezei, Roman Osman, Bin Zhang, Daniel Wacker
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Identification of the bacteriophage nucleus protein interaction network Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2023-09-04 Eray Enustun, Amar Deep, Yajie Gu, Katrina T. Nguyen, Vorrapon Chaikeeratisak, Emily Armbruster, Majid Ghassemian, Elizabeth Villa, Joe Pogliano, Kevin D. Corbett
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All roads lead to MRN regulation at telomeres: different paths to one solution Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2023-08-31 Florian Roisné-Hamelin, Stéphane Marcand
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Structure of the preholoproteasome reveals late steps in proteasome core particle biogenesis Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2023-08-31 Richard M. Walsh, Shaun Rawson, Helena M. Schnell, Benjamin Velez, Tamayanthi Rajakumar, John Hanna
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DNA-PK and the TRF2 iDDR inhibit MRN-initiated resection at leading-end telomeres Nat. Struct. Mol. Biol. (IF 16.8) Pub Date : 2023-08-31 Logan R. Myler, Beatrice Toia, Cara K. Vaughan, Kaori Takai, Andreea M. Matei, Peng Wu, Tanya T. Paull, Titia de Lange, Francisca Lottersberger