
样式: 排序: IF: - GO 导出 标记为已读
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V-ATPase assembly at leaky lysosomes Nat. Struct. Mol. Biol. (IF 10.1) Pub Date : 2025-07-11 Alf Håkon Lystad
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Neuronal VPS13D loss drives microglial activation Nat. Struct. Mol. Biol. (IF 10.1) Pub Date : 2025-07-11 Himanish Basu, Coco Holliday, Isaac M. Chiu
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A marker for sterol-dependent metastatic tropism Nat. Struct. Mol. Biol. (IF 10.1) Pub Date : 2025-07-11 Yuqi Wang, Xi Wang, Charles J. David, Yilong Zou
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A heterotrimeric protein complex assembles the metazoan V-ATPase upon dissipation of proton gradients Nat. Struct. Mol. Biol. (IF 10.1) Pub Date : 2025-07-11 Christopher Nardone, Julian Mintseris, Dingwei He, Justine C. Rutter, Benjamin L. Ebert, Steven P. Gygi, Tom Rapoport
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Comparative CRISPRi screens reveal a human stem cell dependence on mRNA translation-coupled quality control Nat. Struct. Mol. Biol. (IF 10.1) Pub Date : 2025-07-11 Geraldine Rodschinka, Sergio Forcelloni, Felix M. Kühner, Sascha Wani, Henrick Riemenschneider, Dieter Edbauer, Andrew Behrens, Danny D. Nedialkova
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Ferlin structures Nat. Struct. Mol. Biol. (IF 10.1) Pub Date : 2025-07-09 Suhaila Rahman
Ferlins, such as dysferlin, myoferlin and otoferlin, are membrane proteins involved in calcium-dependent vesicle fusion, and how they interact with membranes remains a mystery.To determine the high-resolution structure of a human ferlin, Cretu et al. expressed and purified myoferlin and dysferlin; the proteins remained stable and capable of binding calcium and negatively charged lipids. Unlike earlier
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Structure-guided molecular glues Nat. Struct. Mol. Biol. (IF 10.1) Pub Date : 2025-07-09 Antonio R. Cerullo
Targeted protein degradation is a proven paradigm for advancing the fields of drug discovery, biochemical regulatory networks, and proteostasis. Although several targeting strategies exist, molecular glues — small molecules that stabilize endogenous or non-native protein–protein interactions — are enticing because of their versatility, high cellular uptake and desirable pharmacological properties.
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Glycerol mediates crosstalk between metabolism and trafficking through the golgin Imh1 Nat. Struct. Mol. Biol. (IF 10.1) Pub Date : 2025-07-08 Wan-Yun Chiu, Yi-Hsun Wang, Ming-Chieh Lin, Chun-Chi Lai, Chia-Jung Yu, Fang-Jen S. Lee
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A nanobody-based therapeutic targeting Nipah virus limits viral escape Nat. Struct. Mol. Biol. (IF 10.1) Pub Date : 2025-07-08 Ariel Isaacs, Guillermo Valenzuela Nieto, Xinghai Zhang, Naphak Modhiran, Jennifer Barr, Nazia Thakur, Yu Shang Low, Rhys H. Parry, James B. Barnes, Ronald Jara, Johanna Himelreichs, Yanfeng Yao, Camila Deride, Barbara Barthou-Gatica, Constanza Salinas-Rebolledo, Pamela Ehrenfeld, Jun Jet Hen, Noah Hayes, Devina Paramitha, Mahali S. Morgan, Christopher L. D. McMillan, Martina L. Jones, Trent P. Munro
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Structural insights into transcriptional regulation by the helicase RECQL5 Nat. Struct. Mol. Biol. (IF 10.1) Pub Date : 2025-07-07 Alfredo Jose Florez Ariza, Nicholas Z. Lue, Patricia Grob, Benjamin Kaeser, Jie Fang, Susanne A. Kassube, Eva Nogales
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Structural basis of RECQL5-induced RNA polymerase II transcription braking and subsequent reactivation Nat. Struct. Mol. Biol. (IF 10.1) Pub Date : 2025-07-07 Luojia Zhang, Yuliya Gordiyenko, Tomos Morgan, Catarina Franco, Ana Tufegdžić Vidaković, Suyang Zhang
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Single-cell long-read Hi-C, scNanoHi-C2, details 3D genome reorganization in embryonic-stage germ cells Nat. Struct. Mol. Biol. (IF 10.1) Pub Date : 2025-07-04 Jiansen Lu, Wen Li, Fuchou Tang
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Assembly mechanism of the snRNA nuclear export complex Nat. Struct. Mol. Biol. (IF 10.1) Pub Date : 2025-07-03 Yihu Xie, Yi Ren
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Returning home: fostering growth of Brazilian research Nat. Struct. Mol. Biol. (IF 10.1) Pub Date : 2025-07-03 Sandra M. G. Dias
Returning to Brazil to establish a research laboratory was a decision fueled by hope, resilience, and the desire to create impact, despite ongoing challenges. Choosing to invest in science at home demands a deep personal commitment and a realistic view of the opportunities and obstacles ahead.
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Structural basis for the synergistic assembly of the snRNA export complex Nat. Struct. Mol. Biol. (IF 10.1) Pub Date : 2025-07-03 Etienne Dubiez, William Garland, Maja Finderup Brask, Elisabetta Boeri Erba, Torben Heick Jensen, Jan Kadlec, Stephen Cusack
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SNARE disassembly requires Sec18/NSF side loading Nat. Struct. Mol. Biol. (IF 10.1) Pub Date : 2025-07-02 Yousuf A. Khan, K. Ian White, Richard A. Pfuetzner, Bharti Singal, Luis Esquivies, Garvey Mckenzie, Fang Liu, Katherine DeLong, Ucheor B. Choi, Elizabeth Montabana, Theresa Mclaughlin, William T. Wickner, Axel T. Brunger
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Cell cycle regulation has shaped replication origins in budding yeast Nat. Struct. Mol. Biol. (IF 10.1) Pub Date : 2025-06-30 Chew Theng Lim, Thomas C. R. Miller, Kang Wei Tan, Saurabh Talele, Anne Early, Philip East, Humberto Sánchez, Nynke H. Dekker, Alessandro Costa, John F. X. Diffley
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Mechanisms for licensing origins of DNA replication in eukaryotic cells Nat. Struct. Mol. Biol. (IF 10.1) Pub Date : 2025-06-30 Bruce Stillman, John F. X. Diffley, Janet H. Iwasa
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Structural basis and functional roles for Toll-like receptor binding to Latrophilin in C. elegans development Nat. Struct. Mol. Biol. (IF 10.1) Pub Date : 2025-06-30 Gabriel Carmona-Rosas, Jingxian Li, Jayson J. Smith, Wioletta I. Nawrocka, Shouqiang Cheng, Elana E. Baltrusaitis, Minglei Zhao, Demet Araç, Paschalis Kratsios, Engin Özkan
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A metabolic hub in ciliary and flagellar motion Nat. Struct. Mol. Biol. (IF 10.1) Pub Date : 2025-06-27 Zhuang Xiao, Mingxi Liu
Radial spokes link the doublet microtubules at the periphery of the cilium to the central pair complex at its core. The detailed morphology and function of the radial spoke 3 (RS3) complex was unknown, but a new study reports its structure and reveals its role in metabolism.
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Mouse radial spoke 3 is a metabolic and regulatory hub in cilia Nat. Struct. Mol. Biol. (IF 10.1) Pub Date : 2025-06-27 Yanhe Zhao, Kangkang Song, Amirrasoul Tavakoli, Long Gui, Angeles Fernandez-Gonzalez, Song Zhang, Petras P. Dzeja, S. Alex Mitsialis, Xuewu Zhang, Daniela Nicastro
Cilia are microtubule-based organelles that have important roles in cell sensing, signaling and motility. Recent studies have revealed the atomic structures of many multicomponent ciliary complexes, elucidating their mechanisms of action. However, little is known about the structure, proteome and function of full-length radial spoke 3 (RS3), a conserved complex that transmits mechanochemical signals
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A generalizable multiplexed assay of variant effects for secreted proteins Nat. Struct. Mol. Biol. (IF 10.1) Pub Date : 2025-06-25
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Structure of fungal tRNA ligase Trl1 with RNA reveals conserved substrate-binding principles Nat. Struct. Mol. Biol. (IF 10.1) Pub Date : 2025-06-25 Sandra Köhler, Jürgen Kopp, Satyabrata Maiti, Janusz M. Bujnicki, Jirka Peschek
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The PURB–HOTAIR complex regulates p53-dependent promoter-specific transcriptional activation Nat. Struct. Mol. Biol. (IF 10.1) Pub Date : 2025-06-25 Zhangchuan Xia, Ning Kon, Zhenyi Su, Jingjie Yi, Xu Hua, Hui Zhou, Zhiguo Zhang, Wei Gu
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Microglia promote inflammatory cell death upon neuronal mitochondrial impairment during neurodegeneration Nat. Struct. Mol. Biol. (IF 10.1) Pub Date : 2025-06-25 Guangyan Miao, Tina M. Fortier, Haibo Liu, Dorothy P. Schafer, Katherine A. Fitzgerald, Junhao Mao, Eric H. Baehrecke
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PEX14 condensates recruit receptor and cargo pairs for peroxisomal protein import Nat. Struct. Mol. Biol. (IF 10.1) Pub Date : 2025-06-24 Jianguo Wu, Shupei Lv, Peng Xu, Suyu Yue, Min Zhuang
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P-type ATPase magnesium transporter MgtA acts as a dimer Nat. Struct. Mol. Biol. (IF 10.1) Pub Date : 2025-06-23 Rilee Zeinert, Fei Zhou, Pedro Franco, Jonathan Zöller, Zaid K. Madni, Henry Lessen, L. Aravind, Julian D. Langer, Alexander J. Sodt, Gisela Storz, Doreen Matthies
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ACAD10 and ACAD11 enable mammalian 4-hydroxy acid lipid catabolism Nat. Struct. Mol. Biol. (IF 10.1) Pub Date : 2025-06-19 Edrees H. Rashan, Abigail K. Bartlett, Daven B. Khana, Jingying Zhang, Raghav Jain, Gina Wade, Luciano A. Abriata, Andrew J. Smith, Zakery N. Baker, Taylor Cook, Alana Caldwell, Autumn R. Chevalier, Patrick Forny, Brian F. Pfleger, Matteo Dal Peraro, Peng Yuan, Daniel Amador-Noguez, Judith A. Simcox, David J. Pagliarini
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Reporting light microscopy data in our pages Nat. Struct. Mol. Biol. (IF 10.1) Pub Date : 2025-06-17
We outline a pilot starting at several Nature Portfolio journals aimed at improving and standardizing the reporting of light and fluorescence microscopy experiments.
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H3K27me3 expands the epigenetic control of piRNA transcription Nat. Struct. Mol. Biol. (IF 10.1) Pub Date : 2025-06-17 Arantxa M. L. Rojas, Germano Cecere
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Binding of heterochromatin protein Rhino to a subset of piRNA clusters depends on a combination of two histone marks Nat. Struct. Mol. Biol. (IF 10.1) Pub Date : 2025-06-17 Abdou Akkouche, Emma Kneuss, Susanne Bornelöv, Yoan Renaud, Evelyn L. Eastwood, Jasper van Lopik, Nathalie Gueguen, Mingxuan Jiang, Pau Creixell, Stéphanie Maupetit-Mehouas, Anna Sobieszek, Yifan Gui, Benjamin Czech Nicholson, Emilie Brasset, Gregory J. Hannon
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DMXL1 promotes recruitment of V1-ATPase to lysosomes upon TRPML1 activation Nat. Struct. Mol. Biol. (IF 10.1) Pub Date : 2025-06-17 Chan Lee, Matthew J. G. Eldridge, Miguel A. Gonzalez-Lozano, Thomas Bresnahan, Zachary Niday, Donato Del Camino, Tao Fu, Joao A. Paulo, Magdalene M. Moran, Sophie Helaine, J. Wade Harper
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How protein disorder turns internal dynamics into a long-range regulatory switch Nat. Struct. Mol. Biol. (IF 10.1) Pub Date : 2025-06-16
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Multiplex and multimodal mapping of variant effects in secreted proteins via MultiSTEP Nat. Struct. Mol. Biol. (IF 10.1) Pub Date : 2025-06-13 Nicholas A. Popp, Rachel L. Powell, Melinda K. Wheelock, Kristen J. Holmes, Brendan D. Zapp, Kathryn M. Sheldon, Shelley N. Fletcher, Xiaoping Wu, Shawn Fayer, Alan F. Rubin, Kerry W. Lannert, Alexis T. Chang, John P. Sheehan, Jill M. Johnsen, Douglas M. Fowler
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H2A.Z reinforces maternal H3K4me3 formation and is essential for meiotic progression in mouse oocytes Nat. Struct. Mol. Biol. (IF 10.1) Pub Date : 2025-06-13 Hailiang Mei, Ryoya Hayashi, Chisayo Kozuka, Mami Kumon, Haruhiko Koseki, Azusa Inoue
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H2A.Z is essential for oocyte maturation and fertility in female mouse Nat. Struct. Mol. Biol. (IF 10.1) Pub Date : 2025-06-13 Qianhua Xu, Chunyi Huang, Jia Ming, Xukun Lu, Ling Liu, Zhenhai Du, Zhen Chen, Jie Na, Guohong Li, Yunlong Xiang, Yu Zhang, Wei Xie
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Better SIFI than sorry Nat. Struct. Mol. Biol. (IF 10.1) Pub Date : 2025-06-12 Sara Osman
The ability of metazoan cells to remain attuned to challenging environmental cues such as temperature, osmotic and chemical stresses is essential for developmental resilience. To do so, cells use molecular pathways for stress response signaling. As one example, defective protein import into the mitochondria activates the stress response kinase HRI. In turn, HRI phosphorylates a translation initiation
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UFMylation-dependent quality control of ER-stalled ribosomes Nat. Struct. Mol. Biol. (IF 10.1) Pub Date : 2025-06-12 Dimitris Typas
Although translation is highly processive, ribosomes stall when they are defective or encounter damaged mRNAs. Stalled ribosomes collide with other ribosomes, leading to non-conventional splitting that leaves a large (60S) subunit with an arrested polypeptide (AP) chain attached to the P-site tRNA. Ribosome stalls occur in the cytosol and the endoplasmic reticulum (ER). ER-APs consist of P-tRNA-60S
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Comprehensive analysis of Saccharomyces cerevisiae intron structures in vivo Nat. Struct. Mol. Biol. (IF 10.1) Pub Date : 2025-06-05 Ramya Rangan, Rui Huang, Oarteze Hunter, Phillip Pham, Manuel Ares, Rhiju Das
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Remote on–off switching of protein activity by intrinsically disordered region Nat. Struct. Mol. Biol. (IF 10.1) Pub Date : 2025-06-04 Tuo Ji, Piao Ge, Shan Zhang, Chanjuan Wan, Hailong Liu, Xiaozhan Qu, Feng Zhu, Qingguo Gong, Weiya Xu, Chao Wang, Yucai Wang, Chengdong Huang
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Substrate recognition and allosteric regulation of synaptic vesicle glutamate transporter VGLUT2 Nat. Struct. Mol. Biol. (IF 10.1) Pub Date : 2025-06-03 Fei Li, Jacob Eriksen, Juan A. Oses-Prieto, Yessica K. Gomez, Hongfei Xu, Surabhi Hareendranath, Poulomi Das, Janet Finer-Moore, Phuong Nguyen, Alisa Bowen, Andrew Nelson, Alma Burlingame, Michael Grabe, Robert M. Stroud, Robert H. Edwards
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RNA helicase unravels the secrets of germ granules Nat. Struct. Mol. Biol. (IF 10.1) Pub Date : 2025-06-02 Ekaterina Voronina
Germ granules contribute to the intergenerational transmission of small RNA-mediated silencing in germ cells. A study in Caenorhabditis elegans now investigates the function of the RNA helicase DDX-19 at the interface between the nuclear pore and the cytoplasmic germ granules.
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Distinct tau filament folds in human MAPT mutants P301L and P301T Nat. Struct. Mol. Biol. (IF 10.1) Pub Date : 2025-05-29 Manuel Schweighauser, Yang Shi, Alexey G. Murzin, Holly J. Garringer, Ruben Vidal, Jill R. Murrell, M. Elena Erro, Harro Seelaar, Isidro Ferrer, John C. van Swieten, Bernardino Ghetti, Sjors H. W. Scheres, Michel Goedert
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Structural basis of GluK2 kainate receptor activation by a partial agonist Nat. Struct. Mol. Biol. (IF 10.1) Pub Date : 2025-05-29 Guadalupe Segura-Covarrubias, Changping Zhou, Nebojša Bogdanović, Lisa Zhang, Nami Tajima
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Structure and activation of the human autophagy-initiating ULK1C:PI3KC3-C1 supercomplex Nat. Struct. Mol. Biol. (IF 10.1) Pub Date : 2025-05-29 Minghao Chen, Thanh N. Nguyen, Xuefeng Ren, Grace Khuu, Annan S. I. Cook, Yuanchang Zhao, Ahmet Yildiz, Michael Lazarou, James H. Hurley
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A competitive regulatory mechanism of the Chd1 remodeler is integral to distorting nucleosomal DNA Nat. Struct. Mol. Biol. (IF 10.1) Pub Date : 2025-05-28 Ilana M. Nodelman, Heather J. Folkwein, Wesley S. Glime, Jean-Paul Armache, Gregory D. Bowman
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UFMylation of ARPC4 facilitates lamellipodia formation and promotes cancer metastasis Nat. Struct. Mol. Biol. (IF 10.1) Pub Date : 2025-05-26 Miao Wang, Yu-Sheng Cong
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TRIP12 structures reveal HECT E3 formation of K29 linkages and branched ubiquitin chains Nat. Struct. Mol. Biol. (IF 10.1) Pub Date : 2025-05-26 Samuel A. Maiwald, Laura A. Schneider, Ronnald Vollrath, Joanna Liwocha, Matthew D. Maletic, Kirby N. Swatek, Monique P. C. Mulder, Brenda A. Schulman
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Akt-phosphorylated UFL1 UFMylates ArpC4 to promote metastasis Nat. Struct. Mol. Biol. (IF 10.1) Pub Date : 2025-05-26 Kailiang Zhao, Hao Hu, Debao Fang, Mingran Xie, Jiasheng Chen, Shan Zhang, Suyun Tang, Mingsheng Wu, Xiaorui Guo, Ning Yu, Bao Yao, Wenli Jiang, Chao Wang, Yide Mei
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TRIMming centrosomal assemblies Nat. Struct. Mol. Biol. (IF 10.1) Pub Date : 2025-05-25 Renata Basto
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Mesoscale regulation of microtubule-organizing centers by the E3 ligase TRIM37 Nat. Struct. Mol. Biol. (IF 10.1) Pub Date : 2025-05-25 Zhong Y. Yeow, Sonia Sarju, Fang-Chi Chang, Lance Y. Xu, Mark van Breugel, Andrew J. Holland
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TRIM37 prevents ectopic spindle pole assembly by peptide motif recognition and substrate-dependent oligomerization Nat. Struct. Mol. Biol. (IF 10.1) Pub Date : 2025-05-25 Andrew Bellaart, Amanda Brambila, Jiawei Xu, Francisco Mendez Diaz, Amar Deep, John Anzola, Franz Meitinger, Midori Ohta, Kevin D. Corbett, Arshad Desai, Karen Oegema
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Multiple steps of dynein activation by Lis1 visualized by cryo-EM Nat. Struct. Mol. Biol. (IF 10.1) Pub Date : 2025-05-23 Agnieszka A. Kendrick, Kendrick H. V. Nguyen, Wen Ma, Eva P. Karasmanis, Rommie E. Amaro, Samara L. Reck-Peterson, Andres E. Leschziner
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Structural elucidation of full-length Pfs48/45 in complex with potent monoclonal antibodies isolated from a naturally exposed individual Nat. Struct. Mol. Biol. (IF 10.1) Pub Date : 2025-05-22 Iga Kucharska, Danton Ivanochko, Sophia Hailemariam, Maartje R. Inklaar, Hee Ryung Kim, Karina Teelen, Rianne Stoter, Marga van de Vegte-Bolmer, Geert-Jan van Gemert, Anthony Semesi, Brandon McLeod, Ahyoung Ki, Won-Kyu Lee, John L. Rubinstein, Matthijs M. Jore, Jean-Philippe Julien
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The yin yang of transcriptional memory Nat. Struct. Mol. Biol. (IF 10.1) Pub Date : 2025-05-21 Alejandra Laguillo-Diego, Effie Apostolou
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How we peer review structural data Nat. Struct. Mol. Biol. (IF 10.1) Pub Date : 2025-05-19
We explain why we ask our authors to provide structural data prior to peer review.
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Structure, assembly and inhibition of the Toxoplasma gondii respiratory chain supercomplex Nat. Struct. Mol. Biol. (IF 10.1) Pub Date : 2025-05-19 Andrew E. MacLean, Shikha Shikha, Mariana Ferreira Silva, Max J. Gramelspacher, Aaron Nilsen, Katherine M. Liebman, Sovitj Pou, Rolf W. Winter, Amit Meir, Michael K. Riscoe, J. Stone Doggett, Lilach Sheiner, Alexander Mühleip
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Jerelle Joseph: seeing biomolecular condensates with computation Nat. Struct. Mol. Biol. (IF 10.1) Pub Date : 2025-05-16 Melina Casadio
Jerelle Joseph is an assistant professor at the Department of Chemical and Biological Engineering and the Omenn–Darling Bioengineering Institute at Princeton University in New Jersey. We contacted Jerelle to learn about her research priorities, along with her thoughts about the biomolecular condensates field and how computational biology and molecular simulations can fuel discovery.
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DEK–nucleosome structure shows DEK modulates H3K27me3 and stem cell fate Nat. Struct. Mol. Biol. (IF 10.1) Pub Date : 2025-05-16 Yunfan Shen, Yanhong Liu, Maochao Guo, Song Mao, Rui Chen, Mengran Wang, Zhengbo Li, Yue Li, Wan Chen, Fang Chen, Baixing Wu, Chongyuan Wang, Wei Chen, Huanhuan Cui, Kai Yuan, Hongda Huang