Pregnancy loss is common in humans, but maternal genetic factors modulating its incidence are largely unknown. In a meta-analysis of genome-wide association studies, researchers identified a genetic variant that seems to increase risk of pregnancy loss by dysregulating meiotic recombination between homologous chromosomes during egg formation.

中文翻译：

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一种罕见的遗传变异使母体减数分裂重组偏向于流产风险

流产在人类中很常见，但调节其发生率的母体遗传因素在很大程度上尚不清楚。在全基因组关联研究的荟萃分析中，研究人员发现了一种遗传变异，该变异似乎通过在卵子形成过程中同源染色体之间的减数分裂重组失调而增加流产的风险。