Ubiquitination is an essential process that curtails cellular levels of damaged and redundant proteins. Chemical biologists have harnessed this natural system to induce the degradation of disease-relevant proteins. We reflect here on the potential of ‘degraders’ for targeted selectivity, and discuss the role of computer-aided drug design in shaping future advances.
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Change history
04 March 2024
In the version of the article initially published, an earlier, incorrect version of Fig. 1 was included. This has now been amended in the HTML and PDF versions of the article.
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Acknowledgements
We thank the European Research Council (ERC) (ERC-2021-StG-101040046), ‘la Caixa’ Foundation, FERO-ASEICA, AECC, the Mark Foundation for Cancer Research, the Spanish Ministry of Science and Innovation (PID2020-120110RA-I00 and RYC2020-030061-I), and AGAUR-GenCat (2021SGR01279).
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Whelan, R., Mayor-Ruiz, C. Chemical rewiring of ubiquitination by degraders and their selectivity routes. Nat Struct Mol Biol 31, 205–207 (2024). https://doi.org/10.1038/s41594-024-01215-8
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DOI: https://doi.org/10.1038/s41594-024-01215-8