A corrected version of Figure 1A appears below. From day 0 to day 13, “Fisetin treatment” has been replaced with “KGM treatment”. This article has not yet been cited by other publications.

A kind of rosin epoxy soybean oil acrylate (RBAESO) containing high bio-renewable carbon content was synthesized by using rosin and acrylic acid (AA) to react with epoxidized soybean oil (ESO), and the effects of rosin addition amount on the properties of RBAESO resin and its cured film were investigated. The reaction activity between carboxylic acid and the epoxy group was found improved by introducing

Letter to the Editor

Letter to the Editor

Letter to the Editor

Snippets from Nature’s past.

Letter to the Editor

Despite meeting a clinical and societal need for snakebite antivenom development, VenomAb folded after four years, propelling co-founder Andreas Laustsen-Kiel to a role that combines entrepreneurship and academia.

As mpox becomes a global health emergency, global health leaders must better coordinate their plans and pharmaceutical companies must be prepared to make vaccines affordable.

The UN wants to put communities at the heart of its data-collection efforts in support of the Sustainable Development Goals. Now governments must step up.

If the European Medicines Agency takes an overly cautious approach to selecting specialists to advise on new medicines, people could be left without treatments.

Sources say the nations are close to a deal, but the looming US presidential election is likely bogging it down.

Rejuvenated eggs were more likely to result in healthy offspring.

The first face transplant to also include an eyeball was a surgical coup — but restoring vision remains a challenge.

Scientists come together for unexpected discoveries and ‘collateral happiness’. Plus, ways to persuade a climate sceptic and how the brain knows whether you should cough or sneeze.

An imbalance in the macrophage phenotype is closely related to various inflammatory diseases. Here, we discovered that gypenoside LXXV (GP-75), a type of saponin from Gynostemma pentaphyllum, can reprogram M1-like macrophages into M2-like ones. On a mechanistic level, GP-75 inhibits NF-κB-COX2 signaling by targeting the glucocorticoid receptor (GR). Administration of GP-75, either orally or by intraperitoneal

In this paper, an in-depth study on Fraxinus mandshurica (FM) was conducted, focusing on the chemical constituents, in vitro and in vivo antioxidant activities of flavonoids, acute oral toxicity testing, network pharmacology, and molecular docking in the leaves of FM. The in vitro antioxidant results revealed that the total flavonoid extract (TFE), kaempferol, quercetin, and rutin exhibited similar

Cymbopogon winterianus. Jowitt (syn. Cymbopogon nardus. (L.) W. Watson var. mahapengiri. Winter) (Poaceae family) is native to tropical and semitropical areas of Asia, India, and Indonesia, and is cultivated in South and Central America. In this work, the antiproliferative potential of the essential oil of C. winterianus, its major compound against the HeLa cervical cancer lineage, as well as the major

Kaempferol (KAE) has good biological activity, it is important to isolate kaempferol from tea. In this study, hydrophilic molecularly imprinted resin …

In recent years, with the country advocating the establishment of a resource-saving and environmentally friendly society, people have been pursuing a green and healthy quality of life. The non-toxic, harmless, and biodegradable characteristics of grass and wood dyeing have brought this method back to people's lives. Despite the presence of antibacterial substances such as tetrahydrocannabinol in cannabis

Casuarina equisetifolia stands out as a highly valuable tree species crucial for industries and ecological restoration projects in tropical and subtropical regions, owing to its exceptional salt resistance. However, its growth is hampered in cold and drought-prone areas. Understanding the genetic basis for abiotic stress tolerance is imperative for enhancing stress-resistant breeding efforts of C.

Andrew Robinson reviews five of the best science picks.

As the only ocularist in Uganda, Franklin Wasswa produces customized prosthetic eyes for people who’ve lost their own to injury or disease.

Large-scale evaluation permeates the UK university system, but some countries are rejecting harsh judgements and emphasizing strategic development.

The Pathoplexus database has sequences from Ebola, West Nile virus and another dangerous pathogen.

As wildfires become more frequent and severe, efforts to improve the resilience of forests must be grounded in data and led by Indigenous Peoples.

The engagement-fuelled logic of social media has bequeathed us a world in which what’s trending is a yardstick for what’s true.

A dye that helps to give Doritos their orange colour helps scientists look inside tissues. Plus, the first pictures from NASA’s solar sail and how a loss of bats to disease has knock-on effects for human health.

Urbanization has accelerated dramatically across the world over the past decades. Urban influence on surface temperatures is now being considered as a correction term in climatological datasets. Although prior research has investigated urban influences on precipitation for specific cities or selected thunderstorm cases, a comprehensive examination of urban precipitation anomalies on a global scale

A major next step in hematopoietic stem cell (HSC) biology is to enhance our quantitative understanding of cellular and evolutionary dynamics involved in undisturbed hematopoiesis. Mathematical models have been and continue to be key in this respect, and are most powerful when parameterized experimentally and containing sufficient biological complexity. In this paper, we use data from label propagation

The existence of viable human pathogens in bioaerosols which can cause infection or affect human health has been the subject of little research. In this study, data provided by 10 tropospheric aircraft surveys over Japan in 2014 confirm the existence of a vast diversity of microbial species up to 3,000 m height, which can be dispersed above the planetary boundary layer over distances of up to 2,000

Modern life requires many different metal ions, which enable diverse biochemical functions. It is commonly assumed that metal ions’ environmental availabilities controlled the evolution of early life. We argue that evolution can only explore the chemistry that life encounters, and fortuitous chemical interactions between metal ions and biological compounds can only be selected for if they first occur

Adolescence is a period of substantial social–emotional development, accompanied by dramatic changes to brain structure and function. Social isolation due to lockdowns that were imposed because of the COVID-19 pandemic had a detrimental impact on adolescent mental health, with the mental health of females more affected than males. We assessed the impact of the COVID-19 pandemic lockdowns on adolescent

The presence of livestock inside protected areas, or “livestock encroachment,” is a global conservation concern because livestock is broadly thought to negatively affect wildlife. The Maasai Mara National Reserve (MMNR), Kenya, exemplifies this tension as livestock is believed to have resulted in the declining wildlife populations, contributing to the strict and sometimes violent exclusion measures

Despite growing scientific alarm about anthropogenic climate change, the world is not on track to solve the crisis. Inaction may be partially explained by skepticism about climate change and resistance to proenvironmental policies from people who are motivated to maintain the status quo (i.e., conservative-rightists). Therefore, practical interventions are needed. In the present research program, we

Despite longstanding excitement and progress toward understanding liquid–liquid phase separation in natural and artificial membranes, fundamental questions have persisted about which molecules are required for this phenomenon. Except in extraordinary circumstances, the smallest number of components that has produced large-scale, liquid–liquid phase separation in bilayers has stubbornly remained at

More than 50% of all animal species are insects that undergo complete metamorphosis. The key innovation of these holometabolous insects is a pupal stage between the larva and adult when most structures are completely rebuilt. Why this extreme lifestyle evolved is unclear. Here, we test the hypothesis that a trade-off between growth and differentiation explains the evolution of this novelty. Using a

Are members of marginalized communities silenced on social media when they share personal experiences of racism? Here, we investigate the role of algorithms, humans, and platform guidelines in suppressing disclosures of racial discrimination. In a field study of actual posts from a neighborhood-based social media platform, we find that when users talk about their experiences as targets of racism, their

Although it is well documented that exposure to fine particulate matter (PM 2.5 ) increases the risk of several adverse health outcomes, less is known about its relationship with economic opportunity. Previous studies have relied on regression modeling, which implied strict assumptions regarding confounding adjustments and did not explore geographical heterogeneity. We obtained data for 63,165 US census

The electrochemical series is a useful tool in electrochemistry, but its effectiveness in materials chemistry is limited by the fact that the standard electrochemical series is based on a relatively small set of reactions, many of which are measured in aqueous solutions. To address this problem, we have used machine learning to create an electrochemical series for inorganic materials from tens of thousands

Singlet oxygen ( 1 O 2 ) is important in the environmental remediation field, however, its efficient production has been severely hindered by the ultrafast self-quenching of the as-generated radical precursors in the Fenton-like reactions. Herein, we elaborately designed lamellar anthraquinone-based covalent organic frameworks (DAQ-COF) with sequential localization of the active sites (C═O) at molecular

Mechanical stimuli can affect plant growth, development, and defenses. The role of water spray stimulation, as a prevalent mechanical stimulus in the environment, in crop growth and defense cannot be overlooked. In this study, the effects of water spray on tomato plant growth and defense against the chewing herbivore Helicoverpa armigera and necrotrophic fungus Botrytis cinerea were investigated. Suprathreshold