Curcumin, a polyphenol derived from turmeric, has multiple biological functions, such as anti-inflammatory, antioxidant, antibacterial and, above all, antitumor activity. Colorectal cancer is a common malignancy of the gastrointestinal tract with an extremely high mortality rate. However, the low bioavailability and poor targeting properties of curcumin generally limit its clinical application. In

Context or problem Rotational strip intercropping is a compound planting system using annual intercropping and interannual rotation of intercropped strips. Our previous work showed that the rotational strip intercropping of maize (Zea mays L.) and peanut (Arachis hypogaea L.) (RMP) improved crop productivity in comparison with the continuous monoculture of maize (CM) or peanut (CP). However, the effects

In vineyards, cover crops typically grow concurrently with grapevines and can impart a multitude of agroecosystem services; yet concerns over potential disservices might limit adoption. Reductions in yield and vegetative growth are key disservices of concern, but at sites with high soil resources, reducing excessive vegetative growth is often considered beneficial, if the yield is not strongly penalized

Taxanes, diterpenoids produced by the genus Taxus L., are used to treat a range of cancers, especially paclitaxel (Taxol®), whose therapeutic use has already been confirmed by the U.S. Food and Drug Administration. Taxus baccata L. cell culture is a promising commercial technique for the production of taxanes. In the present study, the effect of gold nanoparticles (AuNPs) (0, 1, 2, and 4 µg/mL) at

Neonicotinoids can control crop pests with high efficiency and low cost and have quickly swept one-fourth of the global insecticide market since the launch of imidacloprid in 1991. Imidacloprid and acetamiprid, the first generation of neonicotinoids, and dinotefuran, the representative of third generation of neonicotinoids, were applied on tomato plants individually to investigate neonicotinoid effects

Programmes to avoid deforestation could have unintentional impacts on a variety of ecosystems.

A fifth fundamental force predicted by some alternative theories of gravity has not been seen in the solar interior.

How to choose a workplace that is welcoming and safe, and where your career will thrive.

Pleasure sensations are blunted in male rodents whose mums ate fatty food during pregnancy.

Moulting fluid from ant pupae is a food source that aids colony success.

Sediment reveals seasonal variation at the start of the Holocene.

Axonal swellings act as a sink for action potentials.

Bias and discrimination are rife in master’s and PhD programmes worldwide, a Nature survey finds.

Cumulus clouds in trade-wind regions are not reduced by the convective mixing of air.

A mobile palate evolved before the origin of modern birds.

A Nigerian disease-surveillance expert and a US epidemiologist have been tracking monkeypox for years. Can their insights help to stop its spread and prevent future outbreaks?

Beak bone from ancient bird revises order of their modern ancestors.

Eisai and Biogen share clinical trial data confirming that lecanemab slows mental decline amid reports of potentially related deaths.

Science funders must remember the value of addressing the intrinsic biological questions that help to explain the natural world.

Tales to tell.

Game theory helps to identify genetic variants that give plants the ability to thrive in crowded conditions.

Snippets from Nature’s past.

Low levels of one type of cholesterol predict heart-disease risk in white people only.

Letter to Editor

Viruses used to target microbes linked to inflammatory bowel disease.

Scientists raced to gather the strongest ever biodiversity evidence base. Time is running out to use it.

The UK’s statistics agency has changed the way it calculates business research spending. It’s hard to tell whether this provides a more accurate picture or an excuse to cut funding.

Enough of silos: develop a joint scientific agenda to understand the intertwined global crises of the Earth system.

‘Mpox’ is the new preferred term for the disease caused by the monkeypox virus. Plus, three problems a plastics treaty could solve and deep bass makes people dance — even when they can’t hear it.

Fieldwork is under way to excavate a rare, well-preserved specimen in central China.

Inflammasomes are cytosolic innate immune complexes that activate caspase-1 upon detection of pathogenic and endogenous dangers1-5, and NLRP3 is an inflammasome sensor of membrane damage highly important in inducing inflammation2,6,7. Here we report cryo-EM structures of disk-shaped active NLRP3 oligomers in complex with ATP𝛾S, the centrosomal kinase NEK7, and the adaptor protein ASC which recruits

Specialists discuss strategies that could help stop plastics contaminating the environment.

Currently, feed enzymes are primarily obtained through fermentation of fungi, bacteria, and other microorganisms. Although the manufacturing technology for feed enzymes has evolved rapidly, the activities of these enzymes decline during the granulating process and the cost of application has increased over time. An alternative approach is the use of genetically modified plants containing complex feed

Meliaceae is a useful plant family owing to its high-quality timber and its many limonoids that have pharmacological and biological activities. Although some genomes of Meliaceae species have been reported, many questions regarding their unique family features, namely wood quality and natural products, have not been answered. In this study, we provide the whole genome sequence of Melia azedarach comprising

Demethylated nobiletins (DMNs), which are generally recognized as the metabolites of orally administered nobiletin, are widely investigated. However, studies related to 8-demethylated-nobiletin, 7-demethylated-nobiletin (7DMN), and 6-demethylated-nobiletin (6DMN) are limited due to the lack of a synthesis method. In this study, a strain of microbe able to metabolize nobiletin was isolated from aged

Scientific evidence on the antithrombotic activity of Kaempferia parviflora (KP) remains limited. The present study investigated the antiplatelet aggregation effect and anticoagulant activity of this plant on human blood. Among four tested fractions, the ethyl acetate (EA) fraction exhibited the strongest inhibitory effect on platelet aggregation (percentage of inhibition %I = 95.07% at 0.4 mg/mL and

Camellia drupifera is mainly distributed in southern China. Due to geographical isolation, the C. drupifera resources in Hainan Island are very different from those in mainland China. However, the genetic variation, differentiation and evolution of C. drupifera have not been revealed. In this study, 22 SRAP markers and 7 chloroplast sequences were used to determine the genetic variation and differentiation