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Design, Synthesis, and Fungicidal Activities of Novel N-(Pyrazol-5-yl)benzamide Derivatives Containing a Diphenylamine Moiety J. Agric. Food Chem. (IF 6.1) Pub Date : 2024-03-18 Yi-Dan Ma, Huan Zhou, Guo-Tai Lin, Ke-Huan Wu, Gong Xu, Xili Liu, Dan Xu
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Piperine Improves Hyperuricemic Nephropathy by Inhibiting URAT1/GLUT9 and the AKT-mTOR Pathway J. Agric. Food Chem. (IF 6.1) Pub Date : 2024-03-18 Lu Li, Kunlu Zhao, Jian Luo, Jinhong Tian, Fengxin Zheng, Xueman Lin, Zijun Xie, Heyang Jiang, Yongmei Li, Zean Zhao, Ting Wu, Jianxin Pang
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Advancing High-Throughput MS-Based Protein Quantification: A Case Study on Quantifying 10 Major Food Allergens by LC-MS/MS Using a One-Sample Multipoint External Calibration Curve J. Agric. Food Chem. (IF 6.1) Pub Date : 2024-03-18 Shupeng Yang, Haopeng Lin, Peijie Yang, Junhong Meng, Mohamed F. Abdallah, Yingnan Shencheng, Ruohan Li, Jianxun Li, Shuyan Liu, Qianqian Li, Peng Lu, Rong Zhang, Yi Li
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Novel Potential of Rose Essential Oil as a Powerful Plant Defense Potentiator J. Agric. Food Chem. (IF 6.1) Pub Date : 2024-03-18 Eiki Kaneko, Kenji Matsui, Ruka Nakahara, Gen-ichiro Arimura
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Functional Melanin Nanoparticles-Assisted Laser Desorption Ionization Mass Spectrometry for High-Sensitivity Detection of TBBPA and TBBPS Contaminations in Animal-Derived Foodstuffs J. Agric. Food Chem. (IF 6.1) Pub Date : 2024-03-18 Yuan Chen, Jiaying Che, Jiagui Wang, Yuanyuan Tuo, Huayu Zhao, Yi Chen, Luheng Sai, Huifang Zhao, Ruiping Zhang
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Mechanism of Dihydromyricetin-Induced Reduction of Furfural Derived from the Amadori Compound: Formation of Adducts between Dihydromyricetin and Furfural or Its Precursors J. Agric. Food Chem. (IF 6.1) Pub Date : 2024-03-18 Pusen Chen, Meigui Huang, Heping Cui, Linhui Feng, Khizar Hayat, Xiaoming Zhang, Chi-Tang Ho
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Linker-Based Pharmacophoric Design and Semisynthesis of Labdane Conjugates Active against Multi-Faceted Inflammatory Targets J. Agric. Food Chem. (IF 6.1) Pub Date : 2024-03-17 Sangeetha Mohan, Lekshmy Krishnan, Nithya Madhusoodanan, Anjali Sobha, Renjitha Jalaja, Alaganandam Kumaran, Naveen Vankadari, Jayamurthy Purushothaman, Sasidhar B. Somappa
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Large Yellow Tea Polysaccharide Alleviates HFD-Induced Intestinal Homeostasis Dysbiosis via Modulating Gut Barrier Integrity, Immune Responses, and the Gut Microbiome J. Agric. Food Chem. (IF 6.1) Pub Date : 2024-03-17 Yan Ma, Hai Xie, Na Xu, Minni Li, Lan Wang, Huifang Ge, Zhongwen Xie, Daxiang Li, Hongyan Wang
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Orientin Promotes Antioxidant Capacity, Mitochondrial Biogenesis, and Fiber Transformation in Skeletal Muscles through the AMPK Pathway J. Agric. Food Chem. (IF 6.1) Pub Date : 2024-03-16 Keshu Liu, Xufeng Li, Zhihui Liu, Xiaoping Ming, Baoai Han, Weisong Cai, Xiuping Yang, Zilin Huang, Zhenxiang Shi, Jianghao Wu, Bin Hao, Xiong Chen
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Platycodin D Ameliorates Cognitive Impairment in Type 2 Diabetes Mellitus Mice via Regulating PI3K/Akt/GSK3β Signaling Pathway J. Agric. Food Chem. (IF 6.1) Pub Date : 2024-03-16 Ya-wei Lu, Li-ya Xie, Meng-han Qi, Shen Ren, Yue-qi Wang, Jun-nan Hu, Zi Wang, Shan Tang, Jing-tian Zhang, Wei Li
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New Antibacterial Peptaibiotics against Plant and Fish Pathogens from the Deep-Sea-Derived Fungus Simplicillium obclavatum EIODSF 020 J. Agric. Food Chem. (IF 6.1) Pub Date : 2024-03-16 Xiao Liang, Jia-Fan Yang, Zhong-Hui Huang, Xuan Ma, Yan Yan, Shu-Hua Qi
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Hydroxytyrosol Alleviates Obesity-Induced Cognitive Decline by Modulating the Expression Levels of Brain-Derived Neurotrophic Factors and Inflammatory Factors in Mice J. Agric. Food Chem. (IF 6.1) Pub Date : 2024-03-15 Shenlin Liu, Yalong Lu, Dan Tian, Tingting Zhang, Chaoqun Zhang, Ching Yuan Hu, Ping Chen, Yonghong Meng
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N1019D Mutant of Limosilactobacillus reuteri 121 4,6-α-Glucanotransferase GtfB Significantly Improved Catalytic Activity J. Agric. Food Chem. (IF 6.1) Pub Date : 2024-03-15 Nana Wang, Jingjing Dong, Xiaoxiao Li, Birte Svensson, Zhengyu Jin, Yuxiang Bai
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Verbose robots, and why some people love Bach: Books in Brief Nature (IF 64.8) Pub Date : 2024-03-15
Andrew Robinson reviews five of the best science picks.
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A year in the life: what I learnt from using a time-tracking spreadsheet Nature (IF 64.8) Pub Date : 2024-03-15
A low-tech solution helped Megan Rogers to increase her productivity and maintain a good work–life balance.
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Building a heart atlas: researchers map organ in stunning detail Nature (IF 64.8) Pub Date : 2024-03-13
Cutting edge imaging techniques reveal how cells organise as the heart develops.
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Mobile delivery of COVID-19 vaccines improved uptake in rural Sierra Leone Nature (IF 64.8) Pub Date : 2024-03-13 Alison Buttenheim, Harsha Thirumurthy
Vaccination rates in rural areas improve when vaccines are delivered.
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Bird-flu threat disrupts Antarctic penguin studies Nature (IF 64.8) Pub Date : 2024-03-15
Projects have been cancelled in an effort to curb the virus’s spread.
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Inside China’s giant underground neutrino lab Nature (IF 64.8) Pub Date : 2024-03-15
Due to come online this year, the JUNO facility will help to determine which type of neutrino has the highest mass — one of the biggest mysteries in physics.
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People, passion, publishable: an early-career researcher’s checklist for prioritizing projects Nature (IF 64.8) Pub Date : 2024-03-15
Stuck between several lines of research? Here’s how we decide which ones to pursue, say Elizabeth Tenney, Jacqueline Chen and McKenzie Preston.
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First US drug approved for a liver disease surging around the world Nature (IF 64.8) Pub Date : 2024-03-15
A therapy called resmetirom improves hallmarks of an obesity-linked condition that can lead to liver failure.
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A fundamental constant in physics gets an update Nature (IF 64.8) Pub Date : 2024-03-14
Scientists controlled a hydrogen atom with electric fields to derive a highly precise estimate of the Rydberg constant.
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Ditching ‘Anthropocene’: why ecologists say the term still matters Nature (IF 64.8) Pub Date : 2024-03-14
Beyond stratigraphic definitions, the name has broader significance for understanding humans’ place on Earth.
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Neural and behavioural state switching during hippocampal dentate spikes Nature (IF 64.8) Pub Date : 2024-03-13 Jordan S. Farrell, Ernie Hwaun, Barna Dudok, Ivan Soltesz
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AIRE relies on Z-DNA to flag gene targets for thymic T cell tolerization Nature (IF 64.8) Pub Date : 2024-03-13 Yuan Fang, Kushagra Bansal, Sara Mostafavi, Christophe Benoist, Diane Mathis
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Blueprinting extendable nanomaterials with standardized protein blocks Nature (IF 64.8) Pub Date : 2024-03-13 Timothy F. Huddy, Yang Hsia, Ryan D. Kibler, Jinwei Xu, Neville Bethel, Deepesh Nagarajan, Rachel Redler, Philip J. Y. Leung, Connor Weidle, Alexis Courbet, Erin C. Yang, Asim K. Bera, Nicolas Coudray, S. John Calise, Fatima A. Davila-Hernandez, Hannah L. Han, Kenneth D. Carr, Zhe Li, Ryan McHugh, Gabriella Reggiano, Alex Kang, Banumathi Sankaran, Miles S. Dickinson, Brian Coventry, T. J. Brunette
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Drought triggers and sustains overnight fires in North America Nature (IF 64.8) Pub Date : 2024-03-13 Kaiwei Luo, Xianli Wang, Mark de Jong, Mike Flannigan
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Fork coupling directs DNA replication elongation and termination Science (IF 56.9) Pub Date : 2024-03-15 Yang Liu, Zhengrong Zhangding, Xuhao Liu, Tingting Gan, Chen Ai, Jinchun Wu, Haoxin Liang, Mohan Chen, Yuefeng Guo, Rusen Lu, Yongpeng Jiang, Xiong Ji, Ning Gao, Daochun Kong, Qing Li, Jiazhi Hu
DNA replication is initiated at multiple loci to ensure timely duplication of eukaryotic genomes. Sister replication forks progress bidirectionally, and replication terminates when two convergent forks encounter one another. To investigate the coordination of replication forks, we developed a replication-associated in situ HiC method to capture chromatin interactions involving nascent DNA. We identify
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Penning micro-trap for quantum computing Nature (IF 64.8) Pub Date : 2024-03-13 Shreyans Jain, Tobias Sägesser, Pavel Hrmo, Celeste Torkzaban, Martin Stadler, Robin Oswald, Chris Axline, Amado Bautista-Salvador, Christian Ospelkaus, Daniel Kienzler, Jonathan Home
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Chatbot AI makes racist judgements on the basis of dialect Nature (IF 64.8) Pub Date : 2024-03-13
Some large language models harbour hidden biases that cannot be removed using standard methods.
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Did ‘alien’ debris hit Earth? Startling claim sparks row at scientific meeting Nature (IF 64.8) Pub Date : 2024-03-13
Astrophysicist Avi Loeb says that an interstellar meteor showered Earth with particles. At a planetary-science conference this week, researchers begged to differ.
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Daily briefing: In most mammal species, males and females are the same size — or females are bigger Nature (IF 64.8) Pub Date : 2024-03-13
Charles Darwin’s claim about male mammals usually being bigger than females is proved wrong. Plus, OpenAI’s Sora can create amazing video from text prompts, and what’s wrong with how we treat the menopause.
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Continuous evolution of compact protein degradation tags regulated by selective molecular glues Science (IF 56.9) Pub Date : 2024-03-15 Jaron A. M. Mercer, Stephan J. DeCarlo, Shourya S. Roy Burman, Vedagopuram Sreekanth, Andrew T. Nelson, Moritz Hunkeler, Peter J. Chen, Katherine A. Donovan, Praveen Kokkonda, Praveen K. Tiwari, Veronika M. Shoba, Arghya Deb, Amit Choudhary, Eric S. Fischer, David R. Liu
Conditional protein degradation tags (degrons) are usually >100 amino acids long or are triggered by small molecules with substantial off-target effects, thwarting their use as specific modulators of endogenous protein levels. We developed a phage-assisted continuous evolution platform for molecular glue complexes (MG-PACE) and evolved a 36–amino acid zinc finger (ZF) degron (SD40) that binds the ubiquitin
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Generalized fear after acute stress is caused by change in neuronal cotransmitter identity Science (IF 56.9) Pub Date : 2024-03-15 Hui-quan Li, Wuji Jiang, Li Ling, Marta Pratelli, Cong Chen, Vaidehi Gupta, Swetha K. Godavarthi, Nicholas C. Spitzer
Overgeneralization of fear to harmless situations is a core feature of anxiety disorders resulting from acute stress, yet the mechanisms by which fear becomes generalized are poorly understood. In this study, we show that generalized fear in mice results from a transmitter switch from glutamate to γ-aminobutyric acid (GABA) in serotonergic neurons of the lateral wings of the dorsal raphe. Similar change
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Ginsenoside Rk3 Regulates Tryptophan Metabolism along the Brain–Gut Axis by Targeting Tryptophan Hydroxylase and Remodeling the Intestinal Microenvironment to Alleviate Depressive-Like Behavior in Mice J. Agric. Food Chem. (IF 6.1) Pub Date : 2024-03-15 Jingjing Shao, Linlin Qu, Yao Liu, Jingjing Zhang, Yannan Liu, Jianjun Deng, Xiaoxuan Ma, Daidi Fan
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Fulvic Acid Promotes Legume–Rhizobium Symbiosis by Stimulating Endogenous Flavonoids Synthesis and Secretion J. Agric. Food Chem. (IF 6.1) Pub Date : 2024-03-15 Xiaoqian Qiu, Wenqian Wang, Jinshui Yang, Dongmei Li, Jian Jiao, Entao Wang, Hongli Yuan
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Corn Oligopeptide Alleviates Nonalcoholic Fatty Liver Disease by Regulating the Sirtuin Signaling Pathway J. Agric. Food Chem. (IF 6.1) Pub Date : 2024-03-15 Yali Xu, Ting Su, Hricha Mishra, Reiko Ando, Yutaka Furutani, Jun Lu, Muyi Cai, Harukazu Suzuki, Wenkui Yu, Xian-Yang Qin
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Myricetin Induces Ferroptosis and Inhibits Gastric Cancer Progression by Targeting NOX4 J. Agric. Food Chem. (IF 6.1) Pub Date : 2024-03-14 Yi Lu, Jingguo Sun, Mingyue Yang, Yuanxin Xing, Wenshuai Zhu, Jingyu Zhu, Xiaoli Ma, Yunshan Wang, Lu Wang, Yanfei Jia
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An efficient genetic transformation system mediated by Rhizobium rhizogenes in fruit trees based on the transgenic hairy root to shoot conversion Plant Biotech. J. (IF 13.8) Pub Date : 2024-03-16 Lin Liu, Jinghua Qu, Chunyan Wang, Miao Liu, Chunmeng Zhang, Xinyue Zhang, Cheng Guo, Changai Wu, Guodong Yang, Jinguang Huang, Kang Yan, Huairui Shu, Chengchao Zheng, Shizhong Zhang
SummaryGenetic transformation is a critical tool for gene editing and genetic improvement of plants. Although many model plants and crops can be genetically manipulated, genetic transformation systems for fruit trees are either lacking or perform poorly. We used Rhizobium rhizogenes to transfer the target gene into the hairy roots of Malus domestica and Actinidia chinensis. Transgenic roots were generated
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PagARGOS promotes low‐lignin wood formation in poplar Plant Biotech. J. (IF 13.8) Pub Date : 2024-03-16 Xiaomin Yao, Guifang Zhang, Geng Zhang, Qian Sun, Cuimei Liu, Jinfang Chu, Yanping Jing, Shihui Niu, Chunxiang Fu, Tedrick Thomas Salim Lew, Jinxing Lin, Xiaojuan Li
SummaryWood formation, which occurs mainly through secondary xylem development, is important not only for supplying raw material for the ‘ligno‐chemical’ industry but also for driving the storage of carbon. However, the complex mechanisms underlying the promotion of xylem formation remain to be elucidated. Here, we found that overexpression of Auxin‐Regulated Gene involved in Organ Size (ARGOS) in
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A Verticillium dahliae exoglucanase as potential HIGS target interacts with a cotton cysteine protease to confer resistance to cotton Verticillium wilt Plant Biotech. J. (IF 13.8) Pub Date : 2024-03-16 Xiaofeng Su, Qi Wang, Tao Zhang, Xiaoyang Ge, Wende Liu, Huiming Guo, Xingfen Wang, Zhengwen Sun, Zhiqiang Li, Hongmei Cheng
Verticillium wilt, caused by the soil-borne pathogenic fungus Verticillium dahliae (Vd), represents a devastating disease impacting cotton (Gossypium spp.). However, the limited efficacy of measures to control Verticillium wilt arises because Vd colonizes the host vascular system, as well as the inherent resilience of Vd resting structures (microsclerotia), to various environmental influences (Fradin
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Development of a transgenic rice line with strong and broad resistance against four devastating rice viruses through expressing a single hairpin RNA construct Plant Biotech. J. (IF 13.8) Pub Date : 2024-03-16 Chenyang Li, Jianxiang Wu, Shuai Fu, Yi Xu, Yaqin Wang, Xiuling Yang, Ying Lan, Feng Lin, Linlin Du, Tong Zhou, Xueping Zhou
Rice is a staple food crop feeding nearly half of the world's population. However, rice production is threatened by devastating viral diseases such as rice black-streaked dwarf virus (RBSDV), southern rice black-streaked dwarf virus (SRBSDV), rice stripe virus (RSV) and rice ragged stunt virus (RRSV) (Wang et al., 2022a). Traditional breeding for viral resistance is challenging due to the lack of natural
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Recessive resistance against beet chlorosis virus is conferred by the eukaryotic translation initiation factor (iso)4E in Beta vulgaris Plant Biotech. J. (IF 13.8) Pub Date : 2024-03-16 Lukas Rollwage, Hilde Van Houtte, Roxana Hossain, Niels Wynant, Glenda Willems, Mark Varrelmann
SummaryEukaryotic translation initiation factors (eIFs) are important for mRNA translation but also pivotal for plant‐virus interaction. Most of these plant‐virus interactions were found between plant eIFs and the viral protein genome‐linked (VPg) of potyviruses. In case of lost interaction due to mutation or deletion of eIFs, the viral translation and subsequent replication within its host is negatively
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Mudanpioside C Discovered from Paeonia suffruticosa Andr. Acts as a Protein Disulfide Isomerase Inhibitor with Antithrombotic Activities J. Agric. Food Chem. (IF 6.1) Pub Date : 2024-03-15 Xingrong Xie, Yatong Zhou, Ziqi Tang, Xinping Yang, Qi Lian, Jihua Liu, Boyang Yu, Xiufeng Liu
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Improving the Effects of Mulberry Leaves and Neochlorogenic Acid on Glucotoxicity-Induced Hepatic Steatosis in High Fat Diet Treated db/db Mice J. Agric. Food Chem. (IF 6.1) Pub Date : 2024-03-15 Ming-Chang Tsai, Chi-Chih Wang, I-Ning Tsai, Meng-Hsun Yu, Mon-Yuan Yang, Yi-Ju Lee, Kuei-Chuan Chan, Chau-Jong Wang
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From Molecular Dynamics to Taste Sensory Perception: A Comprehensive Study on the Interaction of Umami Peptides with the T1R1/T1R3-VFT Receptor J. Agric. Food Chem. (IF 6.1) Pub Date : 2024-03-15 Hengli Meng, Zhiyong Cui, Yanyang Yu, Yingqiu Li, Shui Jiang, Yuan Liu
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Bacillus amyloliquefaciens SC06 Relieving Intestinal Inflammation by Modulating Intestinal Stem Cells Proliferation and Differentiation via AhR/STAT3 Pathway in LPS-Challenged Piglets J. Agric. Food Chem. (IF 6.1) Pub Date : 2024-03-14 Qi Wang, Fei Wang, Yuanhao Zhou, Xiang Li, Shujie Xu, Qian Jin, Weifen Li
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Novel Cyclopenta[c]pyridine Derivatives Based on Natural Cerbinal as Potential Agrochemical Anti-TMV Agents and Insecticides J. Agric. Food Chem. (IF 6.1) Pub Date : 2024-03-14 Ling Li, Changjiang Xu, Jiyong Zou, Zhaoyang Deng, Shengyong You, Qingmin Wang
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Chicoric Acid Alleviates Colitis via Targeting the Gut Microbiota Accompanied by Maintaining Intestinal Barrier Integrity and Inhibiting Inflammatory Responses J. Agric. Food Chem. (IF 6.1) Pub Date : 2024-03-14 Yan Di, Yi Song, Kejia Xu, Qianxu Wang, Li Zhang, Qian Liu, Min Zhang, Xuebo Liu, Yutang Wang
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Integrated Transcriptome and Proteome Analyses of β-Conglycinin-Induced Intestinal Damage in Piglets J. Agric. Food Chem. (IF 6.1) Pub Date : 2024-03-13 Bojiang Li, Shugui Zheng, Shuangyang Yin, Jing Chen, Yu He, Jiaqi Yao, Simiao Liu
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Isolation, Characterization, and Bioherbicidal Potential of the 16-Residue Peptaibols from Emericellopsis sp. XJ1056 J. Agric. Food Chem. (IF 6.1) Pub Date : 2024-03-12 Kainan Song, Yutong Ai, Jianshuang Zhou, Baoqing Dun, Qun Yue, Liwen Zhang, Yuquan Xu, Chen Wang
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Visible and near-infrared spectroscopy predicted leaf nitrogen contents of potato varieties under different growth and management conditions Precision Agric. (IF 6.2) Pub Date : 2024-04-01 Ashmita Rawal, Alfred Hartemink, Yakun Zhang, Yi Wang, Richard A. Lankau, Matthew D. Ruark
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Spectroscopic determination of chlorophyll content in sugarcane leaves for drought stress detection Precision Agric. (IF 6.2) Pub Date : 2024-04-01 Jingyao Gai, Jingyong Wang, Sasa Xie, Lirong Xiang, Ziting Wang
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Identifying strawberry appearance quality based on unsupervised deep learning Precision Agric. (IF 6.2) Pub Date : 2024-04-01 Hongfei Zhu, Xingyu Liu, Hao Zheng, Lianhe Yang, Xuchen Li, Zhongzhi Han
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The DTC microbiome testing industry needs more regulation Science (IF 56.9) Pub Date : 2024-03-15 Diane E. Hoffmann, Erik C. von Rosenvinge, Mary-Claire Roghmann, Francis B. Palumbo, Daniel McDonald, Jacques Ravel
A growing body of research has suggested the potential for improving human health by better understanding the human microbiome. This research has led to the emergence of a global industry selling direct-to-consumer (DTC) microbiome testing services. Regulation of this industry has been generally ignored despite its having made a mark on the lifestyle health and wellness market. Yet companies’ claims
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Divas, captains, ghosts, ants and bumble-bees: collaborator attitudes explained Nature (IF 64.8) Pub Date : 2024-03-15
Olga Lehmann made sense of challenges she faced in teamwork by analysing how she and her colleagues behaved and what she could have done differently.
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A Black mathematical history Nature (IF 64.8) Pub Date : 2024-03-14
Documentary reveals how Black US scholars shaped today’s mathematics community and provides hope for the future.
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More than 4,000 plastic chemicals are hazardous, report finds Nature (IF 64.8) Pub Date : 2024-03-14
Year-long effort compiles comprehensive database of chemicals in plastics.
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The neuroscientist formerly known as Prince’s audio engineer Nature (IF 64.8) Pub Date : 2024-03-14
Susan Rogers worked with the legendary singer-songwriter before earning a PhD in her 50s on auditory memory and how we listen to music throughout life.