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Productive and metabolomic consequences of arginine supplementation in sows during different gestation periods in two different seasons J. Anim. Sci. Biotechnol. (IF 6.3) Pub Date : 2024-09-19 Sara Virdis, Diana Luise, Federico Correa, Luca Laghi, Norma Arrigoni, Roxana Elena Amarie, Andrea Serra, Giacomo Biagi, Clara Negrini, Francesco Palumbo, Paolo Trevisi
The prolificacy of sows (litter size at birth) has markedly increased, leading to higher post-natal mortality. Heat stress can exacerbate this issue. Arginine plays an important role in several physiological pathways; its effect on gestating sows can depend on the period of supplementation. This study evaluated the effects of arginine supplementation on the productive performance and physiological
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Altered microRNA composition in the uterine lumen fluid in cattle (Bos taurus) pregnancies initiated by artificial insemination or transfer of an in vitro produced embryo J. Anim. Sci. Biotechnol. (IF 6.3) Pub Date : 2024-09-13 Fernando H. Biase, Sarah E. Moorey, Julie G. Schnuelle, Soren Rodning, Martha Sofia Ortega, Thomas E. Spencer
MicroRNAs (miRNAs) are presented in the uterine lumen of many mammals, and in vitro experiments have determined that several miRNAs are important for the regulation of endometrial and trophoblast functions. Our aim was to identify and contrast the miRNAs present in extracellular vesicles (EVs) in the uterine lumen fluid (ULF) at the onset of attachment in cattle pregnancies (gestation d 18) initiated
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Effects of replacing soybean meal with enzymolysis-fermentation compound protein feed on growth performance, apparent digestibility of nutrients, carcass traits, and meat quality in growing-finishing pigs J. Anim. Sci. Biotechnol. (IF 6.3) Pub Date : 2024-09-12 Yu Cheng, Jun He, Ping Zheng, Jie Yu, Junning Pu, Zhiqing Huang, Xiangbing Mao, Yuheng Luo, Junqiu Luo, Hui Yan, Aimin Wu, Bing Yu, Daiwen Chen
Addressing the shortage of high-quality protein resources, this study was conducted to investigate the effects of replacing soybean meal (SBM) with different levels of enzymolysis-fermentation compound protein feed (EFCP) in the diets of growing-finishing pigs, focusing on growth performance, nutrients digestibility, carcass traits, and meat quality. Sixty DLY (Duroc × Landrace × Yorkshire) pigs with
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Higher abundance of DLD protein in buffalo bull spermatozoa causes elevated ROS production leading to early sperm capacitation and reduction in fertilizing ability J. Anim. Sci. Biotechnol. (IF 6.3) Pub Date : 2024-09-11 Seema Karanwal, Ankit Pal, Fanny Josan, Aditya Patel, Jatinder Singh Chera, Sonam Yadav, Vikrant Gaur, Preeti Verma, Shiva Badrhan, Vitika Chauhan, Mukesh Bhakat, Tirtha Kumar Datta, Rakesh Kumar
Before fertilization, spermatozoa undergo a crucial maturation step called capacitation, which is a unique event regulates the sperm’s ability for successful fertilization. The capacitation process takes place as the spermatozoa pass through the female reproductive tract (FRT). Dihydrolipoamide dehydrogenase (DLD) protein is a post-pyruvate metabolic enzyme, exhibiting reactive oxygen species (ROS)
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Dietary supplementation of valine, isoleucine, and tryptophan may overcome the negative effects of excess leucine in diets for weanling pigs containing corn fermented protein J. Anim. Sci. Biotechnol. (IF 6.3) Pub Date : 2024-09-10 Andrea P. Mallea, Charmaine D. Espinosa, Su A Lee, Minoy A. Cristobal, Leidy J. Torrez-Mendoza, Hans H. Stein
Diets with high inclusion of corn co-products such as corn fermented protein (CFP) may contain excess Leu, which has a negative impact on feed intake and growth performance of pigs due to increased catabolism of Val and Ile and reduced availability of Trp in the brain for serotonin synthesis. However, we hypothesized that the negative effect of using CFP in diets for weanling pigs may be overcome if
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Host genetics and gut microbiota synergistically regulate feed utilization in egg-type chickens J. Anim. Sci. Biotechnol. (IF 6.3) Pub Date : 2024-09-09 Wenxin Zhang, Fangren Lan, Qianqian Zhou, Shuang Gu, Xiaochang Li, Chaoliang Wen, Ning Yang, Congjiao Sun
Feed efficiency is a crucial economic trait in poultry industry. Both host genetics and gut microbiota influence feed efficiency. However, the associations between gut microbiota and host genetics, as well as their combined contributions to feed efficiency in laying hens during the late laying period, remain largely unclear. In total, 686 laying hens were used for whole-genome resequencing and liver
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Dietary processed former foodstuffs for broilers: impacts on growth performance, digestibility, hematobiochemical profiles and liver gene abundance J. Anim. Sci. Biotechnol. (IF 6.3) Pub Date : 2024-09-08 Karthika Srikanthithasan, Marta Gariglio, Elena Diaz Vicuna, Edoardo Fiorilla, Barbara Miniscalco, Valeria Zambotto, Eleonora Erika Cappone, Nadia Stoppani, Dominga Soglia, Federica Raspa, Joana Nery, Andrea Giorgino, Roser Sala, Andrés Luis Martínez Marínz, Josefa Madrid Sanchez, Achille Schiavone, Claudio Forte
The present experiment aimed to evaluate the effects of commercially processed former foodstuffs (cFF) as dietary substitutes of corn, soybean meal and soybean oil on the growth performance, apparent total tract digestibility (ATTD), hematobiochemical profiles, and liver gene abundance in broiler chickens. Two hundred one-day-old male ROSS-308 chicks were assigned to 4 dietary groups (5 replicates
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Hepatoprotective effects of magnolol in fatty liver hemorrhagic syndrome hens through shaping gut microbiota and tryptophan metabolic profile J. Anim. Sci. Biotechnol. (IF 6.3) Pub Date : 2024-09-06 Yujie Lv, Chaoyue Ge, Lianchi Wu, Zhaoying Hu, Xinyu Luo, Weichen Huang, Shenao Zhan, Xinyu Shen, Dongyou Yu, Bing Liu
Magnolol (MAG) exhibits hepatoprotective activity, however, whether and how MAG regulates the gut microbiota to alleviate fatty liver hemorrhagic syndrome (FLHS) remains unclear. Therefore, we investigated the mechanism of MAG in FLHS laying hens with an emphasis on alterations in the gut–liver axis. We randomly divided 540 56-week-old Hy-line white laying hens with FLSH into 4 groups. The birds were
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Quercetin ameliorates oxidative stress-induced apoptosis of granulosa cells in dairy cow follicular cysts by activating autophagy via the SIRT1/ROS/AMPK signaling pathway J. Anim. Sci. Biotechnol. (IF 6.3) Pub Date : 2024-09-05 Hongwei Duan, Fang Wang, Ke Wang, Shuai Yang, Rong Zhang, Chen Xue, Lihong Zhang, Xiaofei Ma, Xianghong Du, Jian Kang, Yong Zhang, Xingxu Zhao, Junjie Hu, Longfei Xiao
Follicular cysts contribute significantly to reproductive loss in high-yield dairy cows. This results from the death of follicular granulosa cells (GCs) caused by oxidative stress. Quercetin is known to have significant antioxidant and anti-apoptotic effects. However, the effect of quercetin on follicular cysts has yet been elucidated. Therefore, this study aimed to explore the anti-oxidant and anti-apoptosis
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Early-life milk replacer feeding mediates lipid metabolism disorders induced by colonic microbiota and bile acid profiles to reduce body weight in goat model J. Anim. Sci. Biotechnol. (IF 6.3) Pub Date : 2024-09-04 Ke Zhang, Ting Zhang, Mengmeng Guo, Awang Cuoji, Yangbin Xu, Yitong Zhao, Yuxin Yang, Daniel Brugger, Xiaolong Wang, Langda Suo, Yujiang Wu, Yulin Chen
Dysregulation of lipid metabolism and its consequences on growth performance in young ruminants have attracted attention, especially in the context of alternative feeding strategies. This study aims to elucidate the effects of milk replacer (MR) feeding on growth, lipid metabolism, colonic epithelial gene expression, colonic microbiota composition and systemic metabolism in goat kids compared to breast
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Polystyrene nanoplastic exposure actives ferroptosis by oxidative stress-induced lipid peroxidation in porcine oocytes during maturation J. Anim. Sci. Biotechnol. (IF 6.3) Pub Date : 2024-09-03 Yijing He, Tianhang Yu, Heran Li, Qinfeng Sun, Miaoyu Chen, Yiyi Lin, Jianjun Dai, Weihan Wang, Qiao Li, Shiqiang Ju
Polystyrene nanoplastics (PS-NPs) are becoming increasingly prevalent in the environment with great advancements in plastic products, and their potential health hazard to animals has received much attention. Several studies have reported the toxicity of PS-NPs to various tissues and cells; however, there is a paucity of information about whether PS-NPs exposure can have toxic effects on mammalian oocytes
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Methionine deficiency inhibited pyroptosis in primary hepatocytes of grass carp (Ctenopharyngodon idella): possibly via activating the ROS-AMPK-autophagy axis J. Anim. Sci. Biotechnol. (IF 6.3) Pub Date : 2024-09-02 Yuanlin He, Pei Wu, Weidan Jiang, Yang Liu, Xiaowan Jin, Hongmei Ren, Ruinan Zhang, Xiaoqiu Zhou, Lin Feng
Methionine (Met) is the only sulfur-containing amino acid among animal essential amino acids, and methionine deficiency (MD) causes tissue damage and cell death in animals. The common modes of cell death include apoptosis, autophagy, pyroptosis, necroptosis. However, the studies about the major modes of cell death caused by MD have not been reported, which worth further study. Primary hepatocytes from
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Dietary Zn proteinate with moderate chelation strength alleviates heat stress-induced intestinal barrier function damage by promoting expression of tight junction proteins via the A20/NF-κB p65/MMP-2 pathway in the jejunum of broilers J. Anim. Sci. Biotechnol. (IF 6.3) Pub Date : 2024-09-01 Yangyang Hu, Weiyun Zhang, Ke Yang, Xi Lin, Hsiao-Ching Liu, Jack Odle, Miles Todd See, Xiaoyan Cui, Tingting Li, Shengchen Wang, Xiudong Liao, Liyang Zhang, Sufen Li, Yun Hu, Xugang Luo
The aim of this study was to determine whether and how Zn proteinate with moderate chelation strength (Zn-Prot M) can alleviate heat stress (HS)-induced intestinal barrier function damage of broilers. A completely randomized design was used for comparatively testing the effects of Zn proteinate on HS and non-HS broilers. Under high temperature (HT), a 1 (Control, HT-CON) + 2 (Zn source) × 2 (added
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Dietary bile acids supplementation decreases hepatic fat deposition with the involvement of altered gut microbiota and liver bile acids profile in broiler chickens J. Anim. Sci. Biotechnol. (IF 6.3) Pub Date : 2024-08-13 Minghui Wang, Kelin Li, Hongchao Jiao, Jingpeng Zhao, Haifang Li, Yunlei Zhou, Aizhi Cao, Jianming Wang, Xiaojuan Wang, Hai Lin
High-fat diets (HFD) are known to enhance feed conversion ratio in broiler chickens, yet they can also result in hepatic fat accumulation. Bile acids (BAs) and gut microbiota also play key roles in the formation of fatty liver. In this study, our objective was to elucidate the mechanisms through which BA supplementation reduces hepatic fat deposition in broiler chickens, with a focus on the involvement
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Role of immunomodulatory probiotics in alleviating bacterial diarrhea in piglets: a systematic review J. Anim. Sci. Biotechnol. (IF 6.3) Pub Date : 2024-08-12 Sudeb Saha, Fu Namai, Keita Nishiyama, Julio Villena, Haruki Kitazawa
Diarrhea is a common enteric disease in piglets that leads to high mortality and economic losses in swine production worldwide. Antibiotics are commonly used to prevent or treat diarrhea in piglets. However, irrational antibiotic use contributes to the development of resistance in bacteria and antibiotic residues in animal products, threatening public health, while causing gut microbiota dysbiosis
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The influence of iron nutrition on the development of intestine and immune cell divergency in neonatal pigs J. Anim. Sci. Biotechnol. (IF 6.3) Pub Date : 2024-08-11 Yao Liu, Aimin Wu, Bing Yu, Jun He, Jie Yu, Xiangbing Mao, Ping Zheng, Yuheng Luo, Junqiu Luo, Junning Pu, Hui Yan, Daiwen Chen
Appropriate iron supplementation is essential for neonatal growth and development. However, there are few reports on the effects of iron overload on neonatal growth and immune homeostasis. Thus, the aim of this study was to investigate the effects of iron nutrition on neonatal growth and intestinal immunity by administering different levels of iron to neonatal pigs. We found that iron deficiency and
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Recent advances in essential oils and their nanoformulations for poultry feed J. Anim. Sci. Biotechnol. (IF 6.3) Pub Date : 2024-08-10 Fatemeh Movahedi, Nilesh Nirmal, Pengyuan Wang, Hongping Jin, Lisbeth Grøndahl, Li Li
Antibiotics in poultry feed to boost growth performance are becoming increasingly contentious due to concerns over antimicrobial resistance development. Essential oils (EOs), as natural, plant-derived compounds, have demonstrated antimicrobial and antioxidant properties. EOs may potentially improve poultry health and growth performance when included in poultry feed. Nevertheless, the incorporation
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Epigallocatechin-3-gallate protects bovine ruminal epithelial cells against lipopolysaccharide-induced inflammatory damage by activating autophagy J. Anim. Sci. Biotechnol. (IF 6.3) Pub Date : 2024-08-09 Wanli Zhao, Taiyu Shen, Bichen Zhao, Moli Li, Zhaoju Deng, Yihui Huo, Ben Aernouts, Juan J. Loor, Androniki Psifidi, Chuang Xu
Subacute ruminal acidosis (SARA) causes an increase in endotoxin, which can induce immune and inflammatory responses in the ruminal epithelium of dairy cows. In non-ruminants, epigallocatechin-3-gallate (EGCG), a major bioactive ingredient of green tea, is well-known to alleviate inflammation. Whether EGCG confers protection against SARA-induced inflammation and the underlying mechanisms are unknown
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Insights into the interplay between gut microbiota and lipid metabolism in the obesity management of canines and felines J. Anim. Sci. Biotechnol. (IF 6.3) Pub Date : 2024-08-08 Kaiqi Li, Xiangyu Xiao, Yuling Li, Sichen Lu, Jianghang Zi, Xiaoqiang Sun, Jia Xu, Hao-Yu Liu, Xiaoqiong Li, Tongxing Song, Demin Cai
Obesity is a prevalent chronic disease that has significant negative impacts on humans and our companion animals, including dogs and cats. Obesity occurs with multiple comorbidities, such as diabetes, hypertension, heart disease and osteoarthritis in dogs and cats. A direct link between lipid metabolism dysregulation and obesity-associated diseases has been implicated. However, the understanding of
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Melatonin alleviates palmitic acid-induced mitochondrial dysfunction by reducing oxidative stress and enhancing autophagy in bovine endometrial epithelial cells J. Anim. Sci. Biotechnol. (IF 6.3) Pub Date : 2024-08-08 Yi Wang, Jianfei Gong, Nuo Heng, Yingfan Hu, Rui Wang, Huan Wang, Wei He, Ni Zhu, Zhihui Hu, Haisheng Hao, Huabin Zhu, Shanjiang Zhao
Negative energy balance (NEB) typically occurs in dairy cows after delivery. Cows with a high yield are more likely to experience significant NEB. This type of metabolic imbalance could cause ketosis, which is often accompanied by a decline in reproductive performance. However, the molecular mechanisms underlying NEB have yet to be fully elucidated. During excessive NEB, the body fat is extensively
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Effects of bacteriocin-producing Lactiplantibacillus plantarum on bacterial community and fermentation profile of whole-plant corn silage and its in vitro ruminal fermentation, microbiota, and CH4 emissions J. Anim. Sci. Biotechnol. (IF 6.3) Pub Date : 2024-08-07 Ziqian Li, Samaila Usman, Jiayao Zhang, Yixin Zhang, Rina Su, Hu Chen, Qiang Li, Mengya Jia, Tunde Adegoke Amole, Xusheng Guo
Silage is widely used to formulate dairy cattle rations, and the utilization of antibiotics and methane emissions are 2 major problems for a sustainable and environmentally beneficial ruminant production systems. Bacteriocin has received considerable attention because of its potential as an alternative to antibiotics in animal husbandry. However, the impact of bacteriocin-producing lactic acid bacteria
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Astragalus polysaccharides-induced gut microbiota play a predominant role in enhancing of intestinal barrier function of broiler chickens J. Anim. Sci. Biotechnol. (IF 6.3) Pub Date : 2024-08-06 Jiantao Yang, Yanpeng Sun, Qianggang Wang, Shanglin Yu, Yanhe Li, Bin Yao, Xiaojun Yang
The intestinal barrier is the first line of defense against intestinal invasion by pathogens and foreign antigens and is closely associated with the gut microbiota. Astragalus polysaccharides (APS) have a long history of use in traditional Chinese medicine owing to its protective properties against intestinal barrier function. The mechanism of APS-induced gut microbiota enhancing intestinal barrier
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CAMKK2-AMPK axis endows dietary calcium and phosphorus levels with regulatory effects on lipid metabolism in weaned piglets J. Anim. Sci. Biotechnol. (IF 6.3) Pub Date : 2024-08-05 Zhenyan Miao, Yanjie Sun, Zhangjian Feng, Qiwen Wu, Xuefen Yang, Li Wang, Zongyong Jiang, Ying Li, Hongbo Yi
In the realm of swine production, optimizing body composition and reducing excessive fat accumulation is critical for enhancing both economic efficiency and meat quality. Despite the acknowledged impact of dietary calcium (Ca) and phosphorus (P) on lipid metabolism, the precise mechanisms behind their synergistic effects on fat metabolism remain elusive. Research observations have shown a decreasing
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From follicle to blastocyst: microRNA-34c from follicular fluid-derived extracellular vesicles modulates blastocyst quality J. Anim. Sci. Biotechnol. (IF 6.3) Pub Date : 2024-08-04 Camilla Benedetti, Krishna Chaitanya Pavani, Yannick Gansemans, Nima Azari-Dolatabad, Osvaldo Bogado Pascottini, Luc Peelman, Rani Six, Yuan Fan, Xuefeng Guan, Koen Deserranno, Andrea Fernández-Montoro, Joachim Hamacher, Filip Van Nieuwerburgh, Trudee Fair, An Hendrix, Katrien Smits, Ann Van Soom
Within the follicular fluid, extracellular vesicles (EVs) guide oocyte growth through their cargo microRNAs (miRNAs). Here, we investigated the role of EVs and their cargo miRNAs by linking the miRNAs found in EVs, derived from the fluid of an individual follicle, to the ability of its oocyte to become a blastocyst (competent) or not (non-competent). Bovine antral follicles were dissected, categorized
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Lipolysis pathways modulate lipid mediator release and endocannabinoid system signaling in dairy cows’ adipocytes J. Anim. Sci. Biotechnol. (IF 6.3) Pub Date : 2024-08-03 Madison N. Myers, Miguel Chirivi, Jeff C. Gandy, Joseph Tam, Maya Zachut, G. Andres Contreras
As cows transition from pregnancy to lactation, free fatty acids (FFA) are mobilized from adipose tissues (AT) through lipolysis to counter energy deficits. In clinically healthy cows, lipolysis intensity is reduced throughout lactation; however, if FFA release exceeds tissue demands or the liver’s metabolic capacity, lipid byproducts accumulate, increasing cows’ risk of metabolic and infectious disease
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Advances in single-cell transcriptomics in animal research J. Anim. Sci. Biotechnol. (IF 6.3) Pub Date : 2024-08-02 Yunan Yan, Senlin Zhu, Minghui Jia, Xinyi Chen, Wenlingli Qi, Fengfei Gu, Teresa G. Valencak, Jian-Xin Liu, Hui-Zeng Sun
Understanding biological mechanisms is fundamental for improving animal production and health to meet the growing demand for high-quality protein. As an emerging biotechnology, single-cell transcriptomics has been gradually applied in diverse aspects of animal research, offering an effective method to study the gene expression of high-throughput single cells of different tissues/organs in animals.
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Postbiotics from Saccharomyces cerevisiae fermentation stabilize microbiota in rumen liquid digesta during grain-based subacute ruminal acidosis (SARA) in lactating dairy cows J. Anim. Sci. Biotechnol. (IF 6.3) Pub Date : 2024-08-01 Junfei Guo, Zhengxiao Zhang, Le Luo Guan, Ilkyu Yoon, Jan C. Plaizier, Ehsan Khafipour
Subacute ruminal acidosis (SARA) is a common metabolic disorder of high yielding dairy cows, and it is associated with dysbiosis of the rumen and gut microbiome and host inflammation. This study evaluated the impact of two postbiotics from Saccharomyces cerevisiae fermentation products (SCFP) on rumen liquid associated microbiota of lactating dairy cows subjected to repeated grain-based SARA challenges
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Dietary silymarin improves performance by altering hepatic lipid metabolism and cecal microbiota function and its metabolites in late laying hens J. Anim. Sci. Biotechnol. (IF 6.3) Pub Date : 2024-07-13 Yanghao Guo, Yudong Xu, Derun Wang, Shihao Yang, Zehe Song, Rui Li, Xi He
Liver lipid dysregulation is one of the major factors in the decline of production performance in late-stage laying hens. Silymarin (SIL), a natural flavonolignan extracted from milk thistle, is known for its hepatoprotective and lipid-lowering properties in humans. This study evaluates whether SIL can provide similar benefits to late-stage laying hens. A total of 480 68-week-old Lohmann Pink laying
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Lysine 2-hydroxyisobutyrylation levels determined adipogenesis and fat accumulation in adipose tissue in pigs J. Anim. Sci. Biotechnol. (IF 6.3) Pub Date : 2024-07-12 Enfa Yan, Mingyang Tan, Ning Jiao, Linjuan He, Boyang Wan, Xin Zhang, Jingdong Yin
Excessive backfat deposition lowering carcass grade is a major concern in the pig industry, especially in most breeds of obese type pigs. The mechanisms involved in adipogenesis and fat accumulation in pigs remain unclear. Lysine 2-hydroxyisobutyrylation (Khib), is a novel protein post-translational modification (PTM), which play an important role in transcription, energy metabolism and metastasis
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Effects of different energy levels in low-protein diet on liver lipid metabolism in the late-phase laying hens through the gut-liver axis J. Anim. Sci. Biotechnol. (IF 6.3) Pub Date : 2024-07-11 Hong Hu, Ying Huang, Anjian Li, Qianhui Mi, Kunping Wang, Liang Chen, Zelong Zhao, Qiang Zhang, Xi Bai, Hongbin Pan
The energy/protein imbalance in a low-protein diet induces lipid metabolism disorders in late-phase laying hens. Reducing energy levels in the low-protein diet to adjust the energy-to-protein ratio may improve fat deposition, but this also decreases the laying performance of hens. This study investigated the mechanism by which different energy levels in the low-protein diet influences liver lipid metabolism
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Whole-genome analysis reveals distinct adaptation signatures to diverse environments in Chinese domestic pigs J. Anim. Sci. Biotechnol. (IF 6.3) Pub Date : 2024-07-10 Zhen Wang, Bangmin Song, Jianyu Yao, Xingzheng Li, Yan Zhang, Zhonglin Tang, Guoqiang Yi
Long-term natural and artificial selection has resulted in many genetic footprints within the genomes of pig breeds across distinct agroecological zones. Nevertheless, the mechanisms by which these signatures contribute to phenotypic diversity and facilitate environmental adaptation remain unclear. Here, we leveraged whole-genome sequencing data from 82 individuals from 6 domestic pig breeds originating
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Visfatin (NAMPT) affects global gene expression in porcine anterior pituitary cells during the mid-luteal phase of the oestrous cycle J. Anim. Sci. Biotechnol. (IF 6.3) Pub Date : 2024-07-09 Kamil Dobrzyn, Grzegorz Kopij, Marta Kiezun, Ewa Zaobidna, Marlena Gudelska, Barbara Zarzecka, Lukasz Paukszto, Agnieszka Rak, Nina Smolinska, Tadeusz Kaminski
The pituitary belongs to the most important endocrine glands involved in regulating reproductive functions. The proper functioning of this gland ensures the undisturbed course of the oestrous cycle and affects the female’s reproductive potential. It is believed that visfatin, a hormone belonging to the adipokine family, may regulate reproductive functions in response to the female’s metabolic state
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Nano-Se exhibits limited protective effect against heat stress induced poor breast muscle meat quality of broilers compared with other selenium sources J. Anim. Sci. Biotechnol. (IF 6.3) Pub Date : 2024-07-08 Jinzhong Jing, Jiayi Wang, Qian Wu, Shenggang Yin, Zhen He, Jiayong Tang, Gang Jia, Guangmang Liu, Xiaoling Chen, Gang Tian, Jingyi Cai, Bo Kang, Lianqiang Che, Hua Zhao
At present, heat stress (HS) has become a key factor that impairs broiler breeding industry, which causes growth restriction and poor meat quality of broilers. Selenium (Se) is an excellent antioxidant and plays a unique role in meat quality improvement. Recent years, nano-selenium (NanoSe) has received tremendous attention in livestock production, due to its characteristic and good antibacterial performance
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Effects of altering the ratio of C16:0 and cis-9 C18:1 in rumen bypass fat on growth performance, lipid metabolism, intestinal barrier, cecal microbiota, and inflammation in fattening bulls J. Anim. Sci. Biotechnol. (IF 6.3) Pub Date : 2024-07-07 Haixin Bai, Haosheng Zhang, Congwen Wang, Modinat Tolani Lambo, Yang Li, Yonggen Zhang
C16:0 and cis-9 C18:1 may have different effects on animal growth and health due to unique metabolism in vivo. This study was investigated to explore the different effects of altering the ratio of C16:0 and cis-9 C18:1 in fat supplements on growth performance, lipid metabolism, intestinal barrier, cecal microbiota, and inflammation in fattening bulls. Thirty finishing Angus bulls (626 ± 69 kg, 21 ± 0
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Source and level of dietary iron influence semen quality by affecting inflammation, oxidative stress and iron utilization levels in boars J. Anim. Sci. Biotechnol. (IF 6.3) Pub Date : 2024-07-06 Yinghui Wu, Yamei Li, Yueyue Miao, Hongkui Wei, Hefeng Luo, Chunxiao Ren, Yawei Zhang, Juan Chen, Tanghong Wei, Jiyan Deng, Jian Peng
Boars fed a mixed form of inorganic and organic iron in excess of the NRC recommended levels still develop anemia, which suggested that the current level and form of iron supplementation in boar diets may be inappropriate. Therefore, 56 healthy Topeka E line boars aged 15–21 months were randomly divided into 5 groups: basal diet supplemented with 96 mg/kg ferrous sulfate (FeSO4) and 54 mg/kg glycine
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Heat stress affects mammary metabolism by influencing the plasma flow to the glands J. Anim. Sci. Biotechnol. (IF 6.3) Pub Date : 2024-07-05 Jia Zeng, Diming Wang, Huizeng Sun, Hongyun Liu, Feng-Qi Zhao, Jianxin Liu
Environmental heat stress (HS) can have detrimental effects on milk production by compromising the mammary function. Mammary plasma flow (MPF) plays a crucial role in nutrient supply and uptake in the mammary gland. In this experiment, we investigated the physiological and metabolic changes in high-yielding cows exposed to different degrees of HS: no HS with thermal-humidity index (THI) below 68 (No-HS)
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Transcriptomic and epigenomic landscapes of muscle growth during the postnatal period of broilers J. Anim. Sci. Biotechnol. (IF 6.3) Pub Date : 2024-07-04 Shuang Gu, Qiang Huang, Yuchen Jie, Congjiao Sun, Chaoliang Wen, Ning Yang
Broilers stand out as one of the fastest-growing livestock globally, making a substantial contribution to animal meat production. However, the molecular and epigenetic mechanisms underlying the rapid growth and development of broiler chickens are still unclear. This study aims to explore muscle development patterns and regulatory networks during the postnatal rapid growth phase of fast-growing broilers
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Progesterone regulates tissue non-specific alkaline phosphatase (TNSALP) expression and activity in ovine utero-placental tissues J. Anim. Sci. Biotechnol. (IF 6.3) Pub Date : 2024-07-03 Claire Stenhouse, Katherine M. Halloran, Emily C. Hoskins, Robyn M. Moses, Guoyao Wu, Heewon Seo, Gregory A. Johnson, Larry J. Suva, Dana Gaddy, Fuller W. Bazer
Tissue non-specific alkaline phosphatase (TNSALP; encoded by the ALPL gene) has a critical role in the postnatal regulation of phosphate homeostasis, yet how TNSALP activity and expression are regulated during pregnancy remain largely unknown. This study tested the hypothesis that progesterone (P4) and/or interferon tau (IFNT) regulate TNSALP activity during pregnancy in sheep. In Exp. 1, ewes were
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Probiotic Lactobacillus rhamnosus GG improves insulin sensitivity and offspring survival via modulation of gut microbiota and serum metabolite in a sow model J. Anim. Sci. Biotechnol. (IF 6.3) Pub Date : 2024-07-02 Tianle Gao, Ran Li, Liang Hu, Quanfang Hu, Hongmei Wen, Rui Zhou, Peiqiang Yuan, Xiaoling Zhang, Lingjie Huang, Yong Zhuo, Shengyu Xu, Yan Lin, Bin Feng, Lianqiang Che, De Wu, Zhengfeng Fang
Sows commonly experience insulin resistance in late gestation and lactation, causing lower feed intake and milk production, which can lead to higher mortality rates in newborn piglets. The probiotic Lactobacillus rhamnosus GG (LGG) is known to improve insulin resistance. However, whether supplementing LGG can improve insulin sensitivity in sows and enhance lactation performance, particularly the early
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Improving the accuracy of genomic prediction in dairy cattle using the biologically annotated neural networks framework J. Anim. Sci. Biotechnol. (IF 6.3) Pub Date : 2024-07-01 Xue Wang, Shaolei Shi, Md. Yousuf Ali Khan, Zhe Zhang, Yi Zhang
Biologically annotated neural networks (BANNs) are feedforward Bayesian neural network models that utilize partially connected architectures based on SNP-set annotations. As an interpretable neural network, BANNs model SNP and SNP-set effects in their input and hidden layers, respectively. Furthermore, the weights and connections of the network are regarded as random variables with prior distributions
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Prebiotic galactooligosaccharide improves piglet growth performance and intestinal health associated with alterations of the hindgut microbiota during the peri-weaning period J. Anim. Sci. Biotechnol. (IF 6.3) Pub Date : 2024-06-13 Timothy E. Boston, Feng Wang, Xi Lin, Sung Woo Kim, Vivek Fellner, Mark F. Scott, Amanda L. Ziegler, Laurianne Van Landeghem, Anthony T. Blikslager, Jack Odle
Weaning stress reduces growth performance and health of young pigs due in part to an abrupt change in diets from highly digestible milk to fibrous plant-based feedstuffs. This study investigated whether dietary galactooligosaccharide (GOS), supplemented both pre- and post-weaning, could improve growth performance and intestinal health via alterations in the hindgut microbial community. Using a 3 × 2
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The walnut-derived peptide TW-7 improves mouse parthenogenetic embryo development of vitrified MII oocytes potentially by promoting histone lactylation J. Anim. Sci. Biotechnol. (IF 6.3) Pub Date : 2024-06-11 Yaozong Wei, Bo Pan, Jianpeng Qin, Beijia Cao, Tianyi Lv, Jiangfeng Ye, Ao Ning, Kunlin Du, Xiangyi Chen, Shuqi Zou, Shengqin Zang, Guozhi Yu, Tianzeng Song, Qiuxia Liang, Guangbin Zhou
Previous studies have shown that the vitrification of metaphase II (MII) oocytes significantly represses their developmental potential. Abnormally increased oxidative stress is the probable factor; however, the underlying mechanism remains unclear. The walnut-derived peptide TW-7 was initially isolated and purified from walnut protein hydrolysate. Accumulating evidences implied that TW-7 was a powerful
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UCHL1 promotes the proliferation of porcine granulosa cells by stabilizing CCNB1 J. Anim. Sci. Biotechnol. (IF 6.3) Pub Date : 2024-06-11 Shengjie Shi, Huan Yuan, Lutong Zhang, Lei Gao, Lili Zhao, Xiangfang Zeng, Shiyan Qiao, Guiyan Chu, Chuanjiang Cai
The proliferation of porcine ovarian granulosa cells (GCs) is essential to follicular development and the ubiquitin–proteasome system is necessary for maintaining cell cycle homeostasis. Previous studies found that the deubiquitinase ubiquitin carboxyl-terminal hydrolase 1 (UCHL1) regulates female reproduction, especially in ovarian development. However, the mechanism by which UCHL1 regulates porcine
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Effects of methionine supplementation in a reduced protein diet on growth performance, oxidative status, intestinal health, oocyst shedding, and methionine and folate metabolism in broilers under Eimeria challenge J. Anim. Sci. Biotechnol. (IF 6.3) Pub Date : 2024-06-10 Guanchen Liu, Venkata Sesha Reddy Choppa, Milan Kumar Sharma, Hanseo Ko, Janghan Choi, Woo Kyun Kim
This study investigated effects of different methionine (Met) supplementation levels in a reduced protein diet on growth performance, intestinal health, and different physiological parameters in broilers under Eimeria challenge. A total of 600 fourteen-day-old Cobb500 male broilers were challenged with E. maxima, E. tenella, and E. acervulina, and randomly allocated in a 2 × 5 factorial arrangement
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Combining genetic markers, on-farm information and infrared data for the in-line prediction of blood biomarkers of metabolic disorders in Holstein cattle J. Anim. Sci. Biotechnol. (IF 6.3) Pub Date : 2024-06-09 Lucio F. M. Mota, Diana Giannuzzi, Sara Pegolo, Hugo Toledo-Alvarado, Stefano Schiavon, Luigi Gallo, Erminio Trevisi, Alon Arazi, Gil Katz, Guilherme J. M. Rosa, Alessio Cecchinato
Various blood metabolites are known to be useful indicators of health status in dairy cattle, but their routine assessment is time-consuming, expensive, and stressful for the cows at the herd level. Thus, we evaluated the effectiveness of combining in-line near infrared (NIR) milk spectra with on-farm (days in milk [DIM] and parity) and genetic markers for predicting blood metabolites in Holstein cattle
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Current status and challenges for cell-cultured milk technology: a systematic review J. Anim. Sci. Biotechnol. (IF 6.3) Pub Date : 2024-06-08 Hyuk Cheol Kwon, Hyun Su Jung, Vahinika Kothuri, Sung Gu Han
Cellular agriculture is an innovative technology for manufacturing sustainable agricultural products as an alternative to traditional agriculture. While most cellular agriculture is predominantly centered on the production of cultured meat, there is a growing demand for an understanding of the production techniques involved in dairy products within cellular agriculture. This review focuses on the current
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Effect of atractylenolide III on zearalenone-induced Snail1-mediated epithelial–mesenchymal transition in porcine intestinal epithelium J. Anim. Sci. Biotechnol. (IF 6.3) Pub Date : 2024-06-07 Na Yeon Kim, Myoung Ok Kim, Sangsu Shin, Woo-Sung Kwon, Bomi Kim, Joon Yeop Lee, Sang In Lee
The intestinal epithelium performs essential physiological functions, such as nutrient absorption, and acts as a barrier to prevent the entry of harmful substances. Mycotoxins are prevalent contaminants found in animal feed that exert harmful effects on the health of livestock. Zearalenone (ZEA) is produced by the Fusarium genus and induces gastrointestinal dysfunction and disrupts the health and immune
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Hypoxia-mediated programmed cell death is involved in the formation of wooden breast in broilers J. Anim. Sci. Biotechnol. (IF 6.3) Pub Date : 2024-06-06 Xinrui Zhang, Tong Xing, Lin Zhang, Liang Zhao, Feng Gao
Wooden breast (WB) myopathy is a common myopathy found in commercial broiler chickens worldwide. Histological examination has revealed that WB myopathy is accompanied by damage to the pectoralis major (PM) muscle. However, the underlying mechanisms responsible for the formation of WB in broilers have not been fully elucidated. This study aimed to investigate the potential role of hypoxia-mediated programmed
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Bacteria colonization and gene expression related to immune function in colon mucosa is associated with growth in neonatal calves regardless of live yeast supplementation J. Anim. Sci. Biotechnol. (IF 6.3) Pub Date : 2024-06-05 Koki Nishihara, Clothilde Villot, Lautaro Cangiano, Le Luo Guan, Michael Steele
As Holstein calves are susceptible to gastrointestinal disorders during the first week of life, understanding how intestinal immune function develops in neonatal calves is important to promote better intestinal health. Feeding probiotics in early life may contribute to host intestinal health by facilitating beneficial bacteria colonization and developing intestinal immune function. The objective of
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Embryonic thermal manipulation: a potential strategy to mitigate heat stress in broiler chickens for sustainable poultry production J. Anim. Sci. Biotechnol. (IF 6.3) Pub Date : 2024-06-04 Sadid Al Amaz, Birendra Mishra
Due to high environmental temperatures and climate change, heat stress is a severe concern for poultry health and production, increasing the propensity for food insecurity. With climate change causing higher temperatures and erratic weather patterns in recent years, poultry are increasingly vulnerable to this environmental stressor. To mitigate heat stress, nutritional, genetic, and managerial strategies
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Myostatin gene role in regulating traits of poultry species for potential industrial applications J. Anim. Sci. Biotechnol. (IF 6.3) Pub Date : 2024-06-03 Joonbum Lee, Dong-Hwan Kim, Kichoon Lee
The myostatin (MSTN) gene is considered a potential genetic marker to improve economically important traits in livestock, since the discovery of its function using the MSTN knockout mice. The anti-myogenic function of the MSTN gene was further demonstrated in farm animal species with natural or induced mutations. In poultry species, myogenesis in cell culture was regulated by modulation of the MSTN
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Identification of porcine fast/slow myogenic exosomes and their regulatory effects on lipid accumulation in intramuscular adipocytes J. Anim. Sci. Biotechnol. (IF 6.3) Pub Date : 2024-06-02 Tiantian Zhao, Tingting Tian, He Yu, Chaoyue Cao, Ziyi Zhang, Zhaozhao He, Zeqiang Ma, Rui Cai, Fengna Li, Weijun Pang
Pork quality is affected by the type of muscle fibers, which is closely related to meat color, tenderness and juiciness. Exosomes are tiny vesicles with a diameter of approximately 30–150 nm that are secreted by cells and taken up by recipient cells to mediate communication. Exosome-mediated muscle-fat tissue crosstalk is a newly discovered mechanism that may have an important effect on intramuscular
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Effects of grain intervention on hypothalamic function and the metabolome of blood and milk in dairy cows J. Anim. Sci. Biotechnol. (IF 6.3) Pub Date : 2024-06-01 Limei Lin, Kaizhen Guo, Huiting Ma, Jiyou Zhang, Zheng Lai, Weiyun Zhu, Shengyong Mao
The hypothalamus plays a crucial role in the health and productivity of dairy cows, yet studies on its functionality and its impact on peripheral circulation in these animals are relatively scarce, particularly regarding dietary interventions. Therefore, our study undertook a comprehensive analysis, incorporating both metabolomics and transcriptomics, to explore the effects of a grain-based diet on
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Maternal supplementation with n-3 fatty acids affects placental lipid metabolism, inflammation, oxidative stress, the endocannabinoid system, and the neonate cytokine concentrations in dairy cows J. Anim. Sci. Biotechnol. (IF 6.3) Pub Date : 2024-05-21 Priscila dos Santos Silva, Gitit Kra, Yana Butenko, Jayasimha Rayalu Daddam, Yishai Levin, Maya Zachut
The placenta plays a crucial role in supporting and influencing fetal development. We compared the effects of prepartum supplementation with omega-3 (n-3) fatty acid (FA) sources, flaxseed oil (FLX) and fish oil (FO), on the expression of genes and proteins related to lipid metabolism, inflammation, oxidative stress, and the endocannabinoid system (ECS) in the expelled placenta, as well as on FA profile
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Oleanolic acid improved intestinal immune function by activating and potentiating bile acids receptor signaling in E. coli-challenged piglets J. Anim. Sci. Biotechnol. (IF 6.3) Pub Date : 2024-05-18 Chenyu Xue, Hongpeng Jia, Rujing Cao, Wenjie Cai, Weichen Hong, Jianing Tu, Songtao Wang, Qianzhi Jiang, Chongpeng Bi, Anshan Shan, Na Dong
Infection with pathogenic bacteria during nonantibiotic breeding is one of the main causes of animal intestinal diseases. Oleanolic acid (OA) is a pentacyclic triterpene that is ubiquitous in plants. Our previous work demonstrated the protective effect of OA on intestinal health, but the underlying molecular mechanisms remain unclear. This study investigated whether dietary supplementation with OA
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Patterns of alteration in boar semen quality from 9 to 37 months old and improvement by protocatechuic acid J. Anim. Sci. Biotechnol. (IF 6.3) Pub Date : 2024-05-17 Ruizhi Hu, Xizi Yang, Jiatai Gong, Jing Lv, Xupeng Yuan, Mingkun Shi, Chenxing Fu, Bie Tan, Zhiyong Fan, Liang Chen, Hongfu Zhang, Jianhua He, Shusong Wu
Comprehending the patterns of alteration in boar semen quality and identifying effective nutritional interventions are crucial for enhancing the productivity of commercial pig systems. This study aimed to examine the alteration in semen quality in boars, and assess the impact of protocatechuic acid (PCA) on semen quality during the phase of declining semen quality. In Exp. 1, a total of 38 Pig Improvement
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Unveiling the emerging role of curcumin to alleviate ochratoxin A-induced muscle toxicity in grass carp (Ctenopharyngodon idella): in vitro and in vivo studies J. Anim. Sci. Biotechnol. (IF 6.3) Pub Date : 2024-05-12 Piao Zhao, Lin Feng, Weidan Jiang, Pei Wu, Yang Liu, Hongmei Ren, Xiaowan Jin, Lu Zhang, Haifeng Mi, Xiaoqiu Zhou
Ochratoxin A (OTA), a globally abundant and extremely hazardous pollutant, is a significant source of contamination in aquafeeds and is responsible for severe food pollution. The developmental toxicity of OTA and the potential relieving strategy of natural products remain unclear. This study screened the substance curcumin (Cur), which had the best effect in alleviating OTA inhibition of myoblast proliferation
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Large-scale transcriptomic and genomic analyses reveal a novel functional gene SERPINB6 for chicken carcass traits J. Anim. Sci. Biotechnol. (IF 6.3) Pub Date : 2024-05-11 Di Zhao, Ranran Liu, Xiaodong Tan, Huimin Kang, Jie Wang, Zheng Ma, Haiquan Zhao, Hai Xiang, Zhengfen Zhang, Hua Li, Guiping Zhao
Carcass traits are crucial indicators of meat production efficiency. However, the molecular regulatory mechanisms associated with these traits remain unclear. In this study, we conducted comprehensive transcriptomic and genomic analyses on 399 Tiannong partridge chickens to identify key genes and variants associated with carcass traits and to elucidate the underlying regulatory mechanisms. Based on
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Proteo-transcriptomic profiles reveal key regulatory pathways and functions of LDHA in the ovulation of domestic chickens (Gallus gallus) J. Anim. Sci. Biotechnol. (IF 6.3) Pub Date : 2024-05-10 Ruixue Nie, Wenhui Zhang, Haoyu Tian, Junying Li, Yao Ling, Bo Zhang, Hao Zhang, Changxin Wu
In poultry, the smooth transition of follicles from the preovulatory-to-postovulatory phase impacts egg production in hens and can benefit the poultry industry. However, the regulatory mechanism underlying follicular ovulation in avians is a complex biological process that remains unclear. Critical biochemical events involved in ovulation in domestic chickens (Gallus gallus) were evaluated by transcriptomics
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Dietary glycine supplementation enhances syntheses of creatine and glutathione by tissues of hybrid striped bass (Morone saxatilis ♀ × Morone chrysops ♂) fed soybean meal-based diets J. Anim. Sci. Biotechnol. (IF 6.3) Pub Date : 2024-05-09 Wenliang He, Xinyu Li, Guoyao Wu
We recently reported that supplementing glycine to soybean meal-based diets is necessary for the optimum growth of 5- to 40-g (Phase-I) and 110- to 240-g (Phase-II) hybrid striped bass (HSB), as well as their intestinal health. Although glycine serves as an essential substrate for syntheses of creatine and glutathione (GSH) in mammals (e.g., pigs), little is known about these metabolic pathways or