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Phylogenomic characterization and signs of microevolution in the 2022 multi-country outbreak of monkeypox virus Nat. Med. (IF 53.44) Pub Date : 2022-06-24 Joana Isidro, Vítor Borges, Miguel Pinto, Daniel Sobral, João Dourado Santos, Alexandra Nunes, Verónica Mixão, Rita Ferreira, Daniela Santos, Silvia Duarte, Luís Vieira, Maria José Borrego, Sofia Núncio, Isabel Lopes de Carvalho, Ana Pelerito, Rita Cordeiro, João Paulo Gomes
The largest monkeypox virus (MPXV) outbreak described so far in non-endemic countries was identified in May 20221-6. Here, shotgun metagenomics allowed the rapid reconstruction and phylogenomic characterization of the first MPXV outbreak genome sequences, showing that this MPXV belongs to clade 3 and that the outbreak most likely has a single origin. Although 2022 MPXV (lineage B.1) clustered with
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The covid-19 pandemic will end with public health tools, not clinical ones BMJ (IF 39.89) Pub Date : 2022-06-24 Abraar Karan
We need public health innovation from our governments, writes Abraar Karan As a clinician, I rarely see a patient die from covid-19 anymore. Those who end up in the hospital these days have benefited from the immense advances in clinical science that have brought us vaccines, monoclonal antibodies, and antivirals, and taught us how best to use these and other existing medications, such as steroids
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The steady crisis across the NHS BMJ (IF 39.89) Pub Date : 2022-06-24 Danielle Jefferies
Over the course of the pandemic, NHS performance against national waiting time targets has repeatedly hit new lows. More recently NHS performance has plateaued, however it’s plateaued at a level that is putting patients at risk. Performance has flatlined at new depths because of fundamental problems within the NHS. These underlying problems that existed pre-pandemic, notably the workforce crisis, have
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We lose medical secretaries at our peril BMJ (IF 39.89) Pub Date : 2022-06-24 Gerald T Freshwater
Morgan mourns the shrinking of the medical administrative workforce in favour of new technology.1 Using speech to text is not new; 20 years ago, my secretary and I used ViaVoice software on a PC network in our department. I checked the text for obvious errors, she re-checked—which saved me when I saw what was expected, not what was interpreted—then formatted the letters for printing. It worked well
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The UK benefits from a truly National Health Service Lancet (IF 79.321) Pub Date : 2022-06-22 Eddie Barnes, Gordon Brown, David J Kerr
Abstract not available
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Cancer care: widening the scope of innovation Lancet (IF 79.321) Pub Date : 2022-06-23 The Lancet
Abstract not available
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Early introduction of allergenic food for all infants Lancet (IF 79.321) Pub Date : 2022-06-23 Michael R Perkin
Abstract not available
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The 2022 Wakley Prize: compassion and connection Lancet (IF 79.321) Pub Date : 2022-06-23 Jessamy Bagenal, Benjamin Burlton, Florence Costalas, Bethany Gomersall, Joanna Palmer, Paula Preyzner
Abstract not available
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Sharpening the focus on powerful health stories: Highlights 2022 photography competition open for submissions Lancet (IF 79.321) Pub Date : 2022-06-23 Joanna Palmer
Abstract not available
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Offline: The UK, a knave among nations Lancet (IF 79.321) Pub Date : 2022-06-23 Richard Horton
Abstract not available
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Nominees to lead PAHO announced Lancet (IF 79.321) Pub Date : 2022-06-23 Amy Booth
Abstract not available
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Naomi Oreskes: understanding the denial of science Lancet (IF 79.321) Pub Date : 2022-06-23 Aarathi Prasad
Abstract not available
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General practice: a fortunate profession? Lancet (IF 79.321) Pub Date : 2022-06-23 Gavin Francis
Abstract not available
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Global burden of antimicrobial resistance: essential pieces of a global puzzle Lancet (IF 79.321) Pub Date : 2022-06-23 Esmita Charani, Martin McKee, Manica Balasegaram, Marc Mendelson, Sanjeev Singh, Alison H Holmes
Abstract not available
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Global burden of antimicrobial resistance: essential pieces of a global puzzle Lancet (IF 79.321) Pub Date : 2022-06-23 Marlieke E A de Kraker, Stephan Harbarth
Abstract not available
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Global burden of antimicrobial resistance: essential pieces of a global puzzle Lancet (IF 79.321) Pub Date : 2022-06-23 Timothy R Walsh, Rabaab Zahra, Kenneth Iregbu, Sharon J Peacock, Andrew Stewardson
Abstract not available
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Global burden of antimicrobial resistance: essential pieces of a global puzzle Lancet (IF 79.321) Pub Date : 2022-06-23 Denis Mukwege, Prudence Mitangala, Aline Byabene, Emmanuel Busha, Yves Van Laethem, Olivier Vandenberg
Abstract not available
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Global burden of antimicrobial resistance: essential pieces of a global puzzle Lancet (IF 79.321) Pub Date : 2022-06-23 Diane Ashiru-Oredope, Maxencia Nabiryo, Eva M Krockow, Sabiha Essack
Abstract not available
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Global burden of antimicrobial resistance: essential pieces of a global puzzle – Authors' reply Lancet (IF 79.321) Pub Date : 2022-06-23 Mohsen Naghavi, Christopher J L Murray, Kevin S Ikuta, Tomislav Mestrovic, Lucien Swetschinski, Benn Sartorius
Abstract not available
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Early food intervention and skin emollients to prevent food allergy in young children (PreventADALL): a factorial, multicentre, cluster-randomised trial Lancet (IF 79.321) Pub Date : 2022-06-23 Håvard Ove Skjerven, Anine Lie, Riyas Vettukattil, Eva Maria Rehbinder, Marissa LeBlanc, Anna Asarnoj, Kai-Håkon Carlsen, Åshild Wik Despriee, Martin Färdig, Sabina Wärnberg Gerdin, Berit Granum, Hrefna Katrín Gudmundsdóttir, Guttorm Haugen, Gunilla Hedlin, Geir Håland, Christine Monceyron Jonassen, Linn Landrø, Caroline-Aleksi Olsson Mägi, Karin C Lødrup Carlsen
Background Primary prevention of food allergy by early introduction of allergenic foods seems promising. We aimed to determine whether early food introduction or the application of regular skin emollients in infants from a general population reduced the risk of food allergy. Methods This 2 × 2 factorial, cluster-randomised trial was done at Oslo University Hospital and Østfold Hospital Trust, Oslo
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Continuous glucose monitoring device causes consternation on chest x-ray Lancet (IF 79.321) Pub Date : 2022-06-23 Phoebe Wing-Lam Ho, Cheuk-Chun Szeto, Kai-Ming Chow
Abstract not available
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Cancer treatment and survivorship statistics, 2022 CA: Cancer J. Clin. (IF 508.702) Pub Date : 2022-06-23 Kimberly D. Miller, Leticia Nogueira, Theresa Devasia, Angela B. Mariotto, K. Robin Yabroff, Ahmedin Jemal, Joan Kramer, Rebecca L. Siegel
The number of cancer survivors continues to increase in the United States due to the growth and aging of the population as well as advances in early detection and treatment. To assist the public health community in better serving these individuals, the American Cancer Society and the National Cancer Institute collaborate triennially to estimate cancer prevalence in the United States using incidence
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Cross-ancestry genome-wide polygenic score predicts chronic kidney disease Nat. Med. (IF 53.44) Pub Date : 2022-06-23
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Molecular correlates of clinical response and resistance to atezolizumab in combination with bevacizumab in advanced hepatocellular carcinoma Nat. Med. (IF 53.44) Pub Date : 2022-06-23 Andrew X. Zhu, Alexander R. Abbas, Marina Ruiz de Galarreta, Yinghui Guan, Shan Lu, Hartmut Koeppen, Wenjun Zhang, Chih-Hung Hsu, Aiwu Ruth He, Baek-Yeol Ryoo, Thomas Yau, Ahmed O. Kaseb, Adam M. Burgoyne, Farshid Dayyani, Jessica Spahn, Wendy Verret, Richard S. Finn, Han Chong Toh, Amaia Lujambio, Yulei Wang
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Molecular profiling identifies targeted therapy opportunities in pediatric solid cancer Nat. Med. (IF 53.44) Pub Date : 2022-06-23 Alanna J. Church, Laura B. Corson, Pei-Chi Kao, Alma Imamovic-Tuco, Deirdre Reidy, Duong Doan, Wenjun Kang, Navin Pinto, Luke Maese, Theodore W. Laetsch, AeRang Kim, Susan I. Colace, Margaret E. Macy, Mark A. Applebaum, Rochelle Bagatell, Amit J. Sabnis, Daniel A. Weiser, Julia L. Glade-Bender, Alan C. Homans, John Hipps, Haley Harris, Danielle Manning, Alyaa Al-Ibraheemi, Yvonne Li, Hersh Gupta, Andrew
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A Preview of the Dangerous Future of Abortion Bans — Texas Senate Bill 8 N. Engl. J. Med. (IF 91.245) Pub Date : 2022-06-22 Whitney Arey, Klaira Lerma, Anitra Beasley, Lorie Harper, Ghazaleh Moayedi, Kari White
New England Journal of Medicine, Ahead of Print.
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Maternal Vaccination and Risk of Hospitalization for Covid-19 among Infants N. Engl. J. Med. (IF 91.245) Pub Date : 2022-06-22 Natasha B. Halasa, Samantha M. Olson, Mary A. Staat, Margaret M. Newhams, Ashley M. Price, Pia S. Pannaraj, Julie A. Boom, Leila C. Sahni, Kathleen Chiotos, Melissa A. Cameron, Katherine E. Bline, Charlotte V. Hobbs, Aline B. Maddux, Bria M. Coates, Kelly N. Michelson, Sabrina M. Heidemann, Katherine Irby, Ryan A. Nofziger, Elizabeth H. Mack, Laura Smallcomb, Stephanie P. Schwartz, Tracie C. Walker
Background Infants younger than 6 months of age are at high risk for complications of coronavirus disease 2019 (Covid-19) and are not eligible for vaccination. Transplacental transfer of antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) after maternal Covid-19 vaccination may confer protection against Covid-19 in infants. Methods We used a case–control test-negative design
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Genetically Modified Porcine-to-Human Cardiac Xenotransplantation N. Engl. J. Med. (IF 91.245) Pub Date : 2022-06-22 Bartley P. Griffith, Corbin E. Goerlich, Avneesh K. Singh, Martine Rothblatt, Christine L. Lau, Aakash Shah, Marc Lorber, Alison Grazioli, Kapil K. Saharia, Susie N. Hong, Susan M. Joseph, David Ayares, Muhammad M. Mohiuddin
New England Journal of Medicine, Ahead of Print.
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Genetic Modification in Pig-to-Human Transplantation N. Engl. J. Med. (IF 91.245) Pub Date : 2022-06-22 Elizabeth G. Phimister
New England Journal of Medicine, Ahead of Print.
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The Future of Transplantation N. Engl. J. Med. (IF 91.245) Pub Date : 2022-06-22 Jeffrey L. Platt, Marilia Cascalho
New England Journal of Medicine, Ahead of Print.
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Covid-19 Vaccination during Pregnancy — Two for the Price of One N. Engl. J. Med. (IF 91.245) Pub Date : 2022-06-22 Sonja A. Rasmussen, Denise J. Jamieson
New England Journal of Medicine, Ahead of Print.
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Neutralization Escape by SARS-CoV-2 Omicron Subvariants BA.2.12.1, BA.4, and BA.5 N. Engl. J. Med. (IF 91.245) Pub Date : 2022-06-22 Nicole P. Hachmann, Jessica Miller, Ai-ris Y. Collier, John D. Ventura, Jingyou Yu, Marjorie Rowe, Esther A. Bondzie, Olivia Powers, Nehalee Surve, Kevin Hall, Dan H. Barouch
New England Journal of Medicine, Ahead of Print.
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Evaluation of Acute Adverse Events after Covid-19 Vaccination during Pregnancy N. Engl. J. Med. (IF 91.245) Pub Date : 2022-06-22 Malini DeSilva, Jacob Haapala, Gabriela Vazquez-Benitez, Kimberly K. Vesco, Matthew F. Daley, Darios Getahun, Ousseny Zerbo, Allison Naleway, Jennifer C. Nelson, Joshua T.B. Williams, Simon J. Hambidge, Thomas G. Boyce, Candace C. Fuller, Heather S. Lipkind, Eric Weintraub, Michael M. McNeil, Elyse O. Kharbanda
New England Journal of Medicine, Ahead of Print.
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Ten Years of Choosing Wisely to Reduce Low-Value Care N. Engl. J. Med. (IF 91.245) Pub Date : 2022-06-23
New England Journal of Medicine, Volume 386, Issue 25, Page 2442-2443, June 2022.
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Endovascular Therapy for Large Acute Strokes N. Engl. J. Med. (IF 91.245) Pub Date : 2022-06-23
New England Journal of Medicine, Volume 386, Issue 25, Page 2440-2441, June 2022.
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Shorter Treatment for Tuberculosis in Children N. Engl. J. Med. (IF 91.245) Pub Date : 2022-06-23
New England Journal of Medicine, Volume 386, Issue 25, Page 2438-2440, June 2022.
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Reducing Administrative Harm in Medicine — Clinicians and Administrators Together N. Engl. J. Med. (IF 91.245) Pub Date : 2022-06-23 Walter J. O’Donnell
New England Journal of Medicine, Volume 386, Issue 25, Page 2429-2432, June 2022.
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Audio Interview: Vaccinating Young Children against Covid-19 N. Engl. J. Med. (IF 91.245) Pub Date : 2022-06-23 Eric J. Rubin, Lindsey R. Baden, Stephen Morrissey
New England Journal of Medicine, Volume 386, Issue 25, June 2022.
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A Challenge to Respiratory Syncytial Virus Illness in Adults N. Engl. J. Med. (IF 91.245) Pub Date : 2022-06-23 Marie R. Griffin
New England Journal of Medicine, Volume 386, Issue 25, Page 2427-2428, June 2022.
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Case 19-2022: A 29-Year-Old Woman with Jaundice and Chronic Diarrhea N. Engl. J. Med. (IF 91.245) Pub Date : 2022-06-23 Jon S. DuBois, Avinash Kambadakone, Jennifer Y. Wo, M. Lisa Zhang
New England Journal of Medicine, Volume 386, Issue 25, Page 2413-2423, June 2022.
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Bumps in the Road N. Engl. J. Med. (IF 91.245) Pub Date : 2022-06-23 John W. Ostrominski, Tiffany Y. Hsu, Anna C. Garza-Mayers, Anand Vaidya, Derrick J. Todd
New England Journal of Medicine, Volume 386, Issue 25, June 2022.
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Retinoblastoma N. Engl. J. Med. (IF 91.245) Pub Date : 2022-06-23 Crandall E. Peeler, Efren Gonzalez
New England Journal of Medicine, Volume 386, Issue 25, Page 2412-2412, June 2022.
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Philadelphia Chromosome–Positive Acute Lymphoblastic Leukemia N. Engl. J. Med. (IF 91.245) Pub Date : 2022-06-23 Robin Foà, Sabina Chiaretti
New England Journal of Medicine, Volume 386, Issue 25, Page 2399-2411, June 2022.
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Vaccine Efficacy in Adults in a Respiratory Syncytial Virus Challenge Study N. Engl. J. Med. (IF 91.245) Pub Date : 2022-06-23 Beate Schmoele-Thoma, Agnieszka M. Zareba, Qin Jiang, Mohan S. Maddur, Rana Danaf, Alex Mann, Kingsley Eze, Juin Fok-Seang, Golam Kabir, Andrew Catchpole, Daniel A. Scott, Alejandra C. Gurtman, Kathrin U. Jansen, William C. Gruber, Philip R. Dormitzer, Kena A. Swanson
New England Journal of Medicine, Volume 386, Issue 25, Page 2377-2386, June 2022.
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Infertility, recurrent pregnancy loss, and risk of stroke: pooled analysis of individual patient data of 618 851 women BMJ (IF 39.89) Pub Date : 2022-06-22 Chen Liang, Hsin-Fang Chung, Annette J Dobson, Kunihiko Hayashi, Yvonne T van der Schouw, Diana Kuh, Rebecca Hardy, Carol A Derby, Samar R El Khoudary, Imke Janssen, Sven Sandin, Elisabete Weiderpass, Gita D Mishra
Objective To examine the associations of infertility, recurrent miscarriage, and stillbirth with the risk of first non-fatal and fatal stroke, further stratified by stroke subtypes. Design Individual participant pooled analysis of eight prospective cohort studies. Setting Cohort studies across seven countries (Australia, China, Japan, Netherlands, Sweden, the United Kingdom, and the United States)
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Industry sponsorship bias in cost effectiveness analysis: registry based analysis BMJ (IF 39.89) Pub Date : 2022-06-22 Feng Xie, Ting Zhou
Objective To assess the association between industry sponsorship (drug, medical device, and biotechnology companies) and cost effectiveness results in cost effectiveness analysis (CEA). Design Registry based analysis Data source The Tufts Cost-Effectiveness Analysis Registry was used to identify all CEAs published in Medline between 1976 and 2021. Eligibility criteria for selecting studies CEAs that
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The evidence base for US joint commission hospital accreditation standards: cross sectional study BMJ (IF 39.89) Pub Date : 2022-06-23 Sarah A Ibrahim, Kelly A Reynolds, Emily Poon, Murad Alam
Objective To evaluate the evidence upon which standards for hospital accreditation by The Joint Commission on Accreditation of Healthcare Organizations (the Joint Commission) are based. Design Cross sectional study. Setting United States. Participants Four Joint Commission R3 (requirement, rationale, and reference) reports released by July 2018 and intended to become effective between 1 July 2018 and
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Tom Nolan’s research reviews—23 June 2022 BMJ (IF 39.89) Pub Date : 2022-06-23 Tom Nolan
Within a few seconds of typing “vitamin C infusion near me” into Google, I’m ready to book my high dose (40 g) vitamin C infusion for a bargain price of £230. It’s apparently indicated for people who have gastrointestinal issues, who suddenly feel run down, or who have to travel into the city or travel a lot (that is, pretty much everyone). These doctor-run clinics where you go and get a drip of your
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A cursory National Food Strategy lacks substance and joined up thinking on food insecurity BMJ (IF 39.89) Pub Date : 2022-06-23 Sabine Goodwin
In early April 2022, members of the Independent Food Aid Network (IFAN) wrote to Rishi Sunak, the chancellor, and Boris Johnson, the prime minister, to express their “deep concern at the scale of suffering they were already witnessing” as well as their capacity “to prevent people from going hungry in the weeks and months to come.” 1 Independent food banks were reaching breaking point. The Food Standards
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Interventions for mild hyperparathyroidism . . . and other stories BMJ (IF 39.89) Pub Date : 2022-06-23 British Medical Journal Publishing Group
Primary hyperparathyroidism raises the risk of bony fractures, cardiovascular disease, kidney disease, and cancer. But is the increase large enough to justify surgical intervention in people with mild forms of the disease and modest degrees of hypercalcaemia? Probably not, according to the results of a long running randomised controlled trial from eight Scandinavian centres. Among patients allocated
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Antedating examples of “chickenpox” BMJ (IF 39.89) Pub Date : 2022-06-23 Jeffrey K Aronson
The earliest example of the use of the word “chickenpox” in the second edition of the Oxford English Dictionary was from Chambers Cyclopedia of 1727. The antedating quotation I gave …
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Initial health assessments for new migrants: the evidence gap BMJ (IF 39.89) Pub Date : 2022-06-23 Nathaniel J T Aspray, Joanna Dobbin, Abigail Thompson
We welcome the timely article by Knights and colleagues about initial health assessments for new migrants from Afghanistan, though, as the authors point out, this is relevant for any new migrants.1 They are correct that “evidence regarding best …
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An unusual cause of urinary incontinence in a nonagenarian BMJ (IF 39.89) Pub Date : 2022-06-23 S Thompson, J Gan, M Oppenheimer
A previously well, independent woman in her 90s presented to hospital with two days of worsening confusion, new onset urinary incontinence, and increased urinary frequency. Two days before that, she had been started on nitrofurantoin for urinary tract infection (UTI) by her GP. She had a history of hypertension, osteoporosis, mild dementia, chronic obstructive pulmonary disease, peripheral vascular
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Half hearted and half baked: the government’s new food strategy BMJ (IF 39.89) Pub Date : 2022-06-22 Martin White
Human and planetary health will pay the price for this huge missed opportunity The government’s new food strategy for England1 is its response to an independent review led by Henry Dimbleby, non-executive director of the Department for Environment, Farming and Rural Affairs.2 Dimbleby’s review provided a penetrating analysis of the seemingly intractable problems of the food system, showing that it
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Promoting confidence in cost-effectiveness analyses BMJ (IF 39.89) Pub Date : 2022-06-22 Adam J N Raymakers,, Aaron S Kesselheim
Solutions to tackle bias are more important than ever In a linked paper, Xie and colleagues (doi:10.1136/bmj-2021-069573)1 report a comprehensive investigation into the presence of bias in cost-effectiveness analyses conducted with sponsorship from the pharmaceutical or medical device industry. The authors used the Tufts Cost-Effectiveness Analysis Registry to analyse 8192 cost-effectiveness analyses
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Tackling the crisis in primary care BMJ (IF 39.89) Pub Date : 2022-06-23 Charlotte A M Paddison, Rebecca Rosen
Policy makers must avoid the false dichotomy between continuity and enhanced access The Fuller report, published in May 2022, articulates a vision for primary care built around integrated neighbourhood teams.1 These teams would be equivalent in scale to many existing primary care networks and rooted in a sense of shared ownership for improving the population’s wellbeing. It seeks to achieve this through
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Examining our failings BMJ (IF 39.89) Pub Date : 2022-06-23 Tom Moberly
Every day we fail to adequately recognise, acknowledge, and mitigate our biases. These biases affect how we think as individuals and as a society, what interests us, what questions we ask, how we ask them, and what we do with the answers. Society’s failure to examine and tackle its biases is made painfully evident in the racism and sexism that so many doctors experience every day. This month a BMA
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From drug prohibition to regulation: a public health imperative Lancet (IF 79.321) Pub Date : 2022-06-21 Kasia Malinowska-Sempruch, Diederik Lohman
Abstract not available
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Guidelines for pregnant individuals with monkeypox virus exposure Lancet (IF 79.321) Pub Date : 2022-06-21 Pradip Dashraath, Karin Nielsen-Saines, Citra Mattar, Didier Musso, Paul Tambyah, David Baud
Abstract not available
更新日期：2022-06-23
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