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Termination of a Federal Infection Prevention Advisory Committee JAMA (IF 63.1) Pub Date : 2025-06-16 Thomas R. Talbot, Michael Yen-Wei Lin, Deborah S. Yokoe, Lisa L. Maragakis
This Viewpoint discusses the US Centers for Disease Control and Prevention’s Healthcare Infection Control Practices Advisory Committee and how its termination could affect infection prevention standards in the future.
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Tipping Point Analysis JAMA (IF 63.1) Pub Date : 2025-06-16 Yan Liu, Kehua Zhou, Kendra D. Sims
This JAMA Guide to Statistics and Methods explains tipping point analysis, which assesses how a range of hypothetical patterns in missing outcome data in a randomized clinical trial (RCT) would affect the study’s conclusions, and examines its use in an RCT of treatment for hypertension.
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Adrenal Insufficiency in Adults JAMA (IF 63.1) Pub Date : 2025-06-16 Anand Vaidya, James Findling, Irina Bancos
ImportanceAdrenal insufficiency is a syndrome of cortisol deficiency and is categorized as primary, secondary, or glucocorticoid induced. Although primary and secondary adrenal insufficiency are rare, affecting less than 279 per 1 million individuals, glucocorticoid-induced adrenal insufficiency is common.ObservationsPrimary adrenal insufficiency, which involves deficiency of all adrenocortical hormones
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Life Expectancy of American Indian and Alaska Native Persons and Underreporting of Mortality in Vital Statistics JAMA (IF 63.1) Pub Date : 2025-06-16 Jacob Bor, Michael Bird, Jahn K. Hakes, David U. Himmelstein, Gracie Himmelstein, Steffie Woolhandler
ImportanceMortality of American Indian and Alaska Native (AI/AN) persons is known to be high but may be underreported in routine vital statistics.ObjectiveTo estimate age-specific mortality rates and life expectancy for non-Hispanic AI/AN individuals and other racial and ethnic groups, using self-identified race and ethnicity data in a national cohort, circumventing errors due to racial misclassification
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In Alzheimer’s disease, dimers do the damage Nat. Med. (IF 58.7) Pub Date : 2025-06-16
In our 2008 paper (Shankar, G. M. et al. Nat. Med. 14, 837–842; 2008), we moved beyond cellular and animal models to isolate pathogenic forms of amyloid-β directly from human brains and apply them to reproduce key features of AD: synaptic dysfunction, loss of dendritic spines, and impaired memory per se. We identified stable dimers of amyloid-β in Alzheimer’s cerebral cortex and their dose-dependent
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Head injury in older people taking anticoagulants BMJ (IF 93.6) Pub Date : 2025-06-16 Daniel Horner, Catherine McMahon, Kerstin de Wit, Angelos Kolias
### What you need to know A 73 year old man is brought to the emergency department following a ground level fall a few hours earlier. His physiological observations are normal, but he cannot remember any events for an hour preceding the fall. Examination reveals an occipital scalp haematoma, but no focal neurological deficit. His Glasgow coma scale (GCS) score is 15. His has a history of atrial fibrillation
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Unfair welfare: disability cuts will widen England’s north-south divide BMJ (IF 93.6) Pub Date : 2025-06-16 Clare Bambra, Natalie Bennett, Luke Munford, Hannah Davies
Welfare cuts will hit the most deprived areas and the north of England hardest, with long term health and economic harms, write Clare Bambra and colleagues In her Spring Statement in March 2025, the UK Chancellor Rachel Reeves announced several changes to personal independence payments (PIP)—a non-means tested benefit to help with the additional costs of living with a disability or long term health
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The spending review and the NHS BMJ (IF 93.6) Pub Date : 2025-06-16 Chris Ham
The NHS must reduce demand for healthcare with spending increases nearing their limits News reports that the NHS is one of the main beneficiaries of the spending review conceal some inconvenient truths. The uplift in budgets of around 3 per cent a year is welcome, but below the long term average of 3.6 per cent a year. It also requires the NHS to deliver implausible productivity improvements of 2 per
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NHS reorganisation: don’t forget healthcare public health BMJ (IF 93.6) Pub Date : 2025-06-16 Chris Packham, Zafar Iqbal
We strongly agree with Byworth and colleagues that any reorganisation of the NHS must strengthen public health.1 The NHS has a budget of around £192bn, and there is little performance measurement of how population outcomes are impacted by this investment. Using expert public health input to help reduce health inequalities through the actions of health and care services is an important addition to the
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Are house calls making a comeback? BMJ (IF 93.6) Pub Date : 2025-06-16 Indira Subramanian
In the age of telemedicine, house calls remain a vital part of primary care—and are in fact on the rise. Indira Subramanian reports House calls might seem to be a relic of the past, but they are thriving in an age where virtual care is a buzzword. Medicaid data show that spending on home and community based services increased from 1% of total Medicaid expenditure on long term services and supports
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Abortion law reform in the UK BMJ (IF 93.6) Pub Date : 2025-06-16 Jonathan Lord, Nicola Packer, Tonia Antoniazzi, Janet Barter, Lesley Regan
Decriminalisation needed to protect women from persecution Correspondence to: J Lord j.lord@exeter.ac.uk Abortion is still a criminal offence in England and Wales, with access to abortion permitted under specific circumstances defined in the Abortion Act 1967. One of us (Nicola Packer) was recently acquitted after standing trial in England having been accused of an illegal abortion.1 The high profile
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How should I introduce myself to patients? BMJ (IF 93.6) Pub Date : 2025-06-16 Elisabeth Mahase
Getting your introduction right can make a real difference, Elisabeth Mahase hears Anna Harvey Bluemel, academic clinical fellow in obstetrics and gynaecology, says, “Understanding names, roles, and levels of training in medicine are important—both to resident doctors, who represent a wide range of experience across all specialties, and to patients. The complexities of medical hierarchies and changes
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The Mainstreaming Addiction Treatment Act and Pharmacist-Prescribed Buprenorphine. JAMA (IF 63.1) Pub Date : 2025-06-16 Emmy L Tran,S Michaela Rikard,Gery P Guy,Christina A Mikosz
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Frequency and Clinical Outcomes Associated With Tau Positron Emission Tomography Positivity. JAMA (IF 63.1) Pub Date : 2025-06-16 Alexis Moscoso,Fiona Heeman,Sheelakumari Raghavan,Alejandro Costoya-Sánchez,Martijn van Essen,Ismini Mainta,Valle Camacho,Omar Rodríguez-Fonseca,Jesús Silva-Rodríguez,Andrés Perissinotti,Yuna Gu,Jihwan Yun,Debora Peretti,Federica Ribaldi,Emma M Coomans,Wagner S Brum,Michel J Grothe,Pablo Aguiar,Gérard N Bischof,Alexander Drzezga,Sang Won Seo,Sylvia Villeneuve,Maura Malpetti,John T O'Brien,James B Rowe
Importance Tau positron emission tomography (PET) allows in vivo detection of neurofibrillary tangles, a core neuropathologic feature of Alzheimer disease (AD). Objective To provide estimates of the frequency of tau PET positivity and its associated risk of clinical outcomes. Design, Setting, and Participants Longitudinal study using data pooled from 21 cohorts, comprising a convenience sample of 6514
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Clinical Decision Support System for Imaging Requests. JAMA (IF 63.1) Pub Date : 2025-06-16 Pin-Hsuan Wu,Yi-Yu Ho,Ching-Mao Chang
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Clinical Decision Support System for Imaging Requests-Reply. JAMA (IF 63.1) Pub Date : 2025-06-16 Stijntje W Dijk,Thomas Kroencke
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Measurable Residual Disease-Guided Therapy for Chronic Lymphocytic Leukemia. N. Engl. J. Med. (IF 96.2) Pub Date : 2025-06-15 Talha Munir,Sean Girvan,David A Cairns,Adrian Bloor,David Allsup,Abraham M Varghese,Satyen Gohil,Shankara Paneesha,Andrew Pettitt,Toby Eyre,Christopher P Fox,Francesco Forconi,Constantine Balotis,Nicholas Pemberton,Oonagh Sheehy,John Gribben,Nagah Elmusharaf,Simona Gatto,Gavin Preston,Anna Schuh,Renata Walewska,Lelia Duley,Nichola Webster,Surita Dalal,Andrew Rawstron,Dena Howard,Anna Hockaday,Sharon
BACKGROUND An interim analysis of progression-free survival in this trial showed that ibrutinib-venetoclax was superior to fludarabine-cyclophosphamide-rituximab (FCR) among patients with chronic lymphocytic leukemia (CLL). Whether ibrutinib-venetoclax is more effective than ibrutinib alone is unclear. METHODS In this phase 3, multicenter, open-label trial, we randomly assigned patients with CLL to
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Eric Donn Bateman Lancet (IF 98.4) Pub Date : 2025-06-13 Andrew Green
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Open letter in support of WHO Lancet (IF 98.4) Pub Date : 2025-06-13 Ivana Bozicevic, Stjepan Oreskovic, Rieke van der Graaf, Martin McKee
No Abstract
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Challenges of the current yellow fever outbreak in Colombia Lancet (IF 98.4) Pub Date : 2025-06-13 Carlos A Alvarez-Moreno, Alfonso J Rodriguez-Morales
No Abstract
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Genocide in Gaza: moral and ethical failures of medical institutions Lancet (IF 98.4) Pub Date : 2025-06-13 Helena Niu, Marella Bedggood, Matthew Jenkins, Sana Pathan, Daud Saeed, Jon Jureidini
No Abstract
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When I use a word . . . Managing pharmaceutical stocks stocklessly BMJ (IF 93.6) Pub Date : 2025-06-13 Jeffrey K Aronson
Managing stocks of pharmaceutical products is a difficult business, for both hospitals and community pharmacies. In the 1950s the Japanese car manufacturers Toyota introduced a just-in-time system, by which only enough cars were manufactured at any time to satisfy actual or expected demand. In doing so they reduced stocks to near zero, thus reducing costs. Since then, just-in-time systems have been
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Medical AI and Clinician Surveillance - The Risk of Becoming Quantified Workers. N. Engl. J. Med. (IF 96.2) Pub Date : 2025-06-14 I Glenn Cohen,Ifeoma Ajunwa,Ravi B Parikh
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Tongue Atrophy and Fasciculations in Advanced Motor Neuron Disease. N. Engl. J. Med. (IF 96.2) Pub Date : 2025-06-14 Harikrishnan Premdeep,Manish Bhartiya
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Pathobiology - Can We Do Without It? N. Engl. J. Med. (IF 96.2) Pub Date : 2025-06-14 Deborah E Powell,L Maximilian Buja,Richard Conran,Avrum Gotlieb,Vinay Kumar
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The uncertain future of migrant and refugee health Lancet (IF 98.4) Pub Date : 2025-06-12
No Abstract
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Lurbinectedin with atezolizumab maintenance therapy in extensive-stage small-cell lung cancer Lancet (IF 98.4) Pub Date : 2025-06-12 Noura J Choudhury, Marina C Garassino
No Abstract
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First-line immunotherapy combination in squamous cell anal carcinoma: hope in a neglected disease Lancet (IF 98.4) Pub Date : 2025-06-12 Erika Martinelli, Giulia Martini
No Abstract
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New evidence for common practices in carpal tunnel syndrome Lancet (IF 98.4) Pub Date : 2025-06-12 Malin Zimmerman, Lars B Dahlin
No Abstract
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Sierra Leone struggles as mpox surges across Africa Lancet (IF 98.4) Pub Date : 2025-06-12 Paul Adepoju
No Abstract
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Measles outbreak accelerates in Afghanistan Lancet (IF 98.4) Pub Date : 2025-06-12 Samaan Lateef
No Abstract
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Fresh fears over abortion access in Poland Lancet (IF 98.4) Pub Date : 2025-06-12 Ed Holt
No Abstract
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Human reproduction in crisis: causes unknown Lancet (IF 98.4) Pub Date : 2025-06-12 Niels E Skakkebaek, Lærke Priskorn, Rune Lindahl-Jacobsen, Anna-Maria Andersson, David M Kristensen, Astrid Linnea Beck, Lise Aksglaede, Margit Bistrup Fischer, Luiz R Franca, Anders Juul
No Abstract
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Bridging the gap in radiotherapy access in Kenya Lancet (IF 98.4) Pub Date : 2025-06-12 Monicah Kitonga, Marlene Koskei, Lamech Koibarak, Lincoln Sheets
No Abstract
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The revised Declaration of Helsinki protects healthy volunteers Lancet (IF 98.4) Pub Date : 2025-06-12 Jack S Resneck, Urban Wiesing, Dominique Sprumont, Johannes J M van Delden, Ramin W Parsa-Parsi, Amber R Comer, Jake Young, Otmar Kloiber
No Abstract
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The burden of unstable fractures in axial spondyloarthritis Lancet (IF 98.4) Pub Date : 2025-06-12 Nathan Beucler
No Abstract
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Digital acceptance and commitment therapy for fibromyalgia Lancet (IF 98.4) Pub Date : 2025-06-12 Dan Shan
No Abstract
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Digital acceptance and commitment therapy for fibromyalgia – Authors' reply Lancet (IF 98.4) Pub Date : 2025-06-12 Lesley Arnold, R Michael Gendreau, Lance M McCracken, Ben Vaughn, Michael J Rosenbluth
No Abstract
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Beyond deficit models in early childhood development science Lancet (IF 98.4) Pub Date : 2025-06-12 Gabriel Scheidecker, Tatek Abebe, Seye Abimbola, Nandita Chaudhary, Willem E Frankenhuis, Heidi Keller, Yuko Munakata, Bolajoko O Olusanya, Dandara de Oliveira Ramos, Muneera A Rasheed
No Abstract
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Beyond deficit models in early childhood development science – Authors' reply Lancet (IF 98.4) Pub Date : 2025-06-12 Catherine E Draper, Günther Fink, Dana C McCoy, Milagros Nores, Aisha K Yousafzai
No Abstract
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Retifanlimab with carboplatin and paclitaxel for locally recurrent or metastatic squamous cell carcinoma of the anal canal (POD1UM-303/InterAACT-2): a global, phase 3 randomised controlled trial Lancet (IF 98.4) Pub Date : 2025-06-12 Sheela Rao, Emmanuelle Samalin-Scalzi, Ludovic Evesque, Meher Ben Abdelghani, Federica Morano, Amitesh Roy, Laetitia Dahan, Stefano Tamberi, Amandeep Singh Dhadda, Mark P Saunders, Nathalie Casanova, Rosine Guimbaud, Astrid Lievre, Joan Maurel, Marwan Fakih, Chuan Tian, Jill Harrison, Mark M Jones, Mark Cornfeld, Jean-Philippe Spano, Pauline Rochefort
BackgroundRetifanlimab has activity in programmed death ligand 1-positive advanced squamous cell anal carcinoma (SCAC) that has progressed on platinum chemotherapy. We aimed to prospectively assess the benefit of adding retifanlimab to initial carboplatin–paclitaxel for this disease. MethodsThis global, multicentre, double-blind, randomised, controlled, phase 3 trial was done at 70 centres in 12 countries
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Surgery versus corticosteroid injection for carpal tunnel syndrome (DISTRICTS): an open-label, multicentre, randomised controlled trial Lancet (IF 98.4) Pub Date : 2025-06-12 Wijnand A C Palmbergen, Roy Beekman, A Marijne Heeren, Bart F L van Nuenen, Tim W H Alleman, Esther Verstraete, Korné Jellema, Wim I M Verhagen, Leo H Visser, Godard C W de Ruiter, Diederik van de Beek, Corianne A J M de Borgie, Johannes A Bogaards, Rob M A de Bie, Camiel Verhamme
BackgroundSurgery and corticosteroid injections are established treatments for carpal tunnel syndrome, but the optimal treatment strategy remains unclear. This study aimed to compare starting treatment with surgery versus starting with a corticosteroid injection. MethodsWe conducted an open-label, randomised controlled trial across 31 hospitals in the Netherlands. Eligible patients, diagnosed with
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Inclusion of medical students in the next generation of clinician scientist training programs Nat. Med. (IF 58.7) Pub Date : 2025-06-13 Deniz Buyukkaplan, Yaren Canpolat, Andrea Cuschieri, Devin Inan, Deniz Koc, Benedikt Pelzer
We appreciate the insights provided by Melk et al. in their Comment1 in Nature Medicine. The authors effectively highlight the importance of structured programs in preparing clinician scientists to bridge the gap between clinical practice and research. However, we would like to emphasize the critical role of medical students in this ecosystem and the need for greater accessibility and support at the
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How AI can deliver the Human Exposome Project Nat. Med. (IF 58.7) Pub Date : 2025-06-13 Thomas Hartung
An ambitious Human Exposome Project aims to reveal how our environment shapes our health.
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The power of patient engagement at Peace and Love Hospitals in Ghana Nat. Med. (IF 58.7) Pub Date : 2025-06-13 Lawrencia Bawuah Dsane, Beatrice W. Addai
In today’s evolving healthcare landscape, patient engagement has emerged as a cornerstone of delivering high-quality care. By incorporating patient voices throughout the care life cycle, including survivorship, healthcare systems are fostering a more holistic and inclusive approach to treatment and recovery. Modern patient engagement strategies prioritize the active involvement of patients at every
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Education of healthcare professionals to improve guideline adherence in atrial fibrillation: the STEEER-AF cluster-randomized clinical trial Nat. Med. (IF 58.7) Pub Date : 2025-06-13 Dipak Kotecha, Karina V. Bunting, Samir Mehta, Philipp Sommer, Maciej Sterliński, Kim Rajappan, Lluís Mont, Eduard Guasch, Serge Boveda, Giuseppe Boriani, Yongzhong Sun, Colinda van Deutekom, Chris P. Gale, Tom J. R. De Potter, Isabelle C. van Gelder
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Strategies for shortening tuberculosis therapy Nat. Med. (IF 58.7) Pub Date : 2025-06-13 Véronique A. Dartois, Valerie Mizrahi, Radojka M. Savic, Jared A. Silverman, David Hermann, Clifton E. Barry
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Football can’t ignore its sugar problem BMJ (IF 93.6) Pub Date : 2025-06-12 Chris van Tulleken, Carlos A Monteiro
Soda giants have exploited the world’s most popular sport for commercial gain, and FIFA has an opportunity to lead by example by dropping them as sponsors of the 2025 Club World Cup, write Chris van Tulleken and Carlos A Monteiro During the 2022 FIFA World Cup in Qatar, one name dominated the field—and it wasn’t a player. Coca-Cola was ubiquitous,1 appearing on massive billboards, in halftime commercials
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Spending review leaves a greater need for clarity on healthcare priorities BMJ (IF 93.6) Pub Date : 2025-06-13 Sally Gainsbury
The notion that the health service has emerged as a “winner” from the chancellor’s spending review is a bit like congratulating someone who has just won back the face value of a scratch card. It certainly could have been worse, but the NHS is not going to feel materially better off compared to the last decade. Indeed, after adjusting for changes in NHS employer pension contributions and rising national
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The assisted dying bill continues through UK parliament, with legal momentum but also lingering questions BMJ (IF 93.6) Pub Date : 2025-06-13 Nancy Preston, Suzanne Ost
Assisted dying laws must be transparent, ethically sound, and sensitive to the concerns of patients and practitioners, write Nancy Preston and Suzanne Ost The Terminally Ill Adults (End of Life) Bill is set to continue its report stage on Friday 13 June, before the crucial vote at third reading that will determine its fate.1 If the bill passes third reading it will go to the House of Lords to proceed
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Alternatives to A&E for mental health risk reinforcing a dangerous divide between body and mind BMJ (IF 93.6) Pub Date : 2025-06-13 James Downs
Patients don’t always present with cases that fall neatly into “mental” or “physical” boxes, writes James Downs I wanted to feel optimistic when the NHS recently announced that it will be opening specialist mental health centres as an alternative to A&E for people experiencing a mental health crisis.1 Anyone who’s ever sought help in a hospital during a psychiatric crisis—as I have—knows that emergency
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Widening access to medical school: students need ongoing focused support BMJ (IF 93.6) Pub Date : 2025-06-13 Harj K Kaul
Simpson and colleagues call for consistency of access standards across UK medical schools.1 In my role as an occupational health physician at medical and foundation schools, I have observed that a larger percentage of students from the widening participation programme need additional support for factors including impostor syndrome or self esteem issues, …
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Graft-versus-Host Disease Prophylaxis with Cyclophosphamide and Cyclosporin. N. Engl. J. Med. (IF 96.2) Pub Date : 2025-06-13 David J Curtis,Sushrut S Patil,John Reynolds,Duncan Purtill,Clinton Lewis,David S Ritchie,David J Gottlieb,David T Yeung,Eric Wong,Siok-Keen Tey,Travis Perera,John Moore,Rachel M Koldej,Richard De Abreu Lourenco,John Stubbs,C Orla Morrissey,Nadia Munsef,Andrea Arenas,Geoffrey R Hill,
BACKGROUND Allogeneic peripheral-blood stem-cell transplantation (SCT) from a matched related donor after myeloablative conditioning is the preferred curative treatment for patients with high-risk blood cancers. The combination of a calcineurin inhibitor and an antimetabolite remains standard care for graft-versus-host disease (GVHD) prophylaxis in these patients. Data from two randomized trials have
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Intravenous Rehydration for Severe Acute Malnutrition with Gastroenteritis. N. Engl. J. Med. (IF 96.2) Pub Date : 2025-06-13 Kathryn Maitland,San Maurice Ouattara,Hadiza Sainna,Abdullahi Chara,Oluwakemi F Ogundipe,Temmy Sunyoto,M Hamaluba,Peter Olupot-Olupot,Florence Alaroker,Roisin Connon,Amadou Saidou Maguina,William Okiror,Denis Amorut,Eric Mwajombo,Emmanuel Oguda,Christabel Mogaka,Céline Langendorf,Juan Emmanuel Dewez,Iza Ciglenecki,Diana M Gibb,Matthew E Coldiron,Roberta Petrucci,Elizabeth C George,
BACKGROUND International recommendations advise against the use of intravenous rehydration therapy in children with severe acute malnutrition because of the concern about fluid overload, but evidence to support this concern is lacking. Given the high mortality associated with the current recommendations, the adoption of intravenous rehydration strategies might improve outcomes. METHODS We conducted
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Proportional-Assist Ventilation for Minimizing the Duration of Mechanical Ventilation. N. Engl. J. Med. (IF 96.2) Pub Date : 2025-06-13 Karen J Bosma,Karen E A Burns,Claudio M Martin,Yoanna Skrobik,Jordi Mancebo Cortés,Sorcha Mulligan,Myriam Lafreniere-Roula,Kevin E Thorpe,Juan Carlos Suárez Montero,Indalecio Morán Chorro,Núria Rodríguez-Farré,Ron Butler,Tracey Bentall,Gaëtan Beduneau,Pauline Enguerrand,Marlene Santos,Thomas Piraino,Savino Spadaro,Federica Montanaro,John Basmaji,Eileen Campbell,Alain Mercat,François M Beloncle,Guillaume
BACKGROUND In critically ill patients, acceleration of liberation from mechanical ventilation is important in order to reduce the risk of complications and to improve long-term outcomes. Whether the use of proportional-assist ventilation with load-adjustable gain factors (PAV+) results in a shorter time to successful liberation from mechanical ventilation than pressure-support ventilation (PSV) is
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RFK Jr names eight new members of vaccine committee after mass firing. BMJ (IF 93.6) Pub Date : 2025-06-13 Janice Hopkins Tanne
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Intravenous rehydration safe for children with severe acute malnutrition, study reports. BMJ (IF 93.6) Pub Date : 2025-06-13 Elgan Manton-Roseblade
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Sickle cell disease: Government commits funding to widen access to specialist blood machines. BMJ (IF 93.6) Pub Date : 2025-06-13 Jacqui Wise
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Rehabilitation after discharge from ICU is often poorly coordinated, NCEPOD finds. BMJ (IF 93.6) Pub Date : 2025-06-13 Jacqui Young
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NHS waiting list falls in England, but leaders warn of "long way to go". BMJ (IF 93.6) Pub Date : 2025-06-13 Gareth Iacobucci