-
Dismantling the Overpolicing of Black Residents N. Engl. J. Med. (IF 158.5) Pub Date : 2023-09-30 Joshua Ellis, Onyeka Otugo, Adaira Landry, Alden Landry
Black residents face higher rates of remedial interventions and dismissal than do their White counterparts. Such overpolicing affects the mental health of trainees as well as their careers.
-
Offline: We have a decade Lancet (IF 168.9) Pub Date : 2023-09-28 Richard Horton
Abstract not available
-
Cautionary notes on the COVID-19 re-infection study Lancet (IF 168.9) Pub Date : 2023-09-28 Zhi Qu
Abstract not available
-
COVID toes, newborn blue toes, and prepartum SARS-CoV-2 infection – Authors' reply Lancet (IF 168.9) Pub Date : 2023-09-28 Christoph Hochmayr, Ursula Kiechl-Kohlendorfer, Elke Griesmaier
Abstract not available
-
Garetosmab in fibrodysplasia ossificans progressiva: a randomized, double-blind, placebo-controlled phase 2 trial Nat. Med. (IF 82.9) Pub Date : 2023-09-28 Maja Di Rocco, Eduardo Forleo-Neto, Robert J. Pignolo, Richard Keen, Philippe Orcel, Thomas Funck-Brentano, Christian Roux, Sami Kolta, Annalisa Madeo, Judith S. Bubbear, Jacek Tabarkiewicz, Małgorzata Szczepanek, Javier Bachiller-Corral, Angela M. Cheung, Kathryn M. Dahir, Esmée Botman, Pieter G. Raijmakers, Mona Al Mukaddam, Lianne Tile, Cynthia Portal-Celhay, Neena Sarkar, Peijie Hou, Bret J. Musser
-
When I use a word . . . Amending the 1972 Poisons Act BMJ (IF 105.7) Pub Date : 2023-09-29 Jeffrey K Aronson
The 1972 Poisons Act was introduced to enable registered pharmacists, under the aegis of the Royal Pharmaceutical Society, to regulate the sale of non-medicinal poisons and subsequently of explosives precursors. Since then it has undergone several amendments, the latest of which is about to come into force (on 1 October 2023), under The Control of Poisons and Explosives Precursors Regulations 2023
-
Leila Lessof: public health leader and trainer whose farsighted ideas came to the fore in the HIV/AIDS epidemic BMJ (IF 105.7) Pub Date : 2023-09-29 Rebecca Wallersteiner
Leila Lessof, former director of Public Health Islington and Parkside Health Authority, has died at the age of 89. She was born into a Jewish medical family in London, to Lionel Liebster, a GP in Tottenham, and Renee (née Segolov). Her grandfather, Leopold, also a doctor, came to London from Vienna, to escape antisemitism and had to requalify at the Royal London Hospital before he could practise in
-
Maurice Lessof: clinical immunologist, allergologist, and medical educator BMJ (IF 105.7) Pub Date : 2023-09-29 Rebecca Wallersteiner
Leila and Maurice Lessof Maurice Lessof, clinical immunologist; emeritus professor of medicine, King’s, Guy’s, and St Thomas’ hospitals; and chairman of Lewisham Hospitals NHS Trust, has died at the age of 99. Lessof was born in London, the son of Noah Lessof and Fanny (née Slonim). He grew up in Clapton, east London, with his sister, Elizabeth, on the same street as all his cousins. As the only boy
-
The humanitarian crisis in Nagorno-Karabakh Lancet (IF 168.9) Pub Date : 2023-09-28 Robert Peter Gale, Armen Muradyan, Samvel Danelyan, Narek Manukyan, Maria V Babak, Stella Arakelyan, Gevorg Tamamyan, Jemma Arakelyan
Abstract not available
-
Racism and the 2023 Australian constitutional referendum Lancet (IF 168.9) Pub Date : 2023-09-28 Ian Anderson, Yin Paradies, Marcia Langton, Ray Lovett, Tom Calma
Abstract not available
-
Efficacy and safety of the neonatal Fc receptor inhibitor efgartigimod in adults with primary immune thrombocytopenia (ADVANCE IV): a multicentre, randomised, placebo-controlled, phase 3 trial Lancet (IF 168.9) Pub Date : 2023-09-28 Catherine M Broome, Vickie McDonald, Yoshitaka Miyakawa, Monica Carpenedo, David J Kuter, Hanny Al-Samkari, James B Bussel, Marie Godar, Jaume Ayguasanosa, Kristof De Beuf, Francesco Rodeghiero, Marc Michel, Adrian Newland
Background Primary immune thrombocytopenia is an autoimmune disorder mediated partly by platelet autoantibodies, resulting in thrombocytopenia, bleeding, and constitutional symptoms. Efgartigimod, a first-in-class novel human IgG1 Fc fragment, binds the neonatal Fc receptor with high affinity and thus reduces serum IgG concentrations, including autoantibodies. The objective of this study was to evaluate
-
Inhibition of neonatal Fc receptor as a treatment for immune thrombocytopenia Lancet (IF 168.9) Pub Date : 2023-09-28 Syed Mahamad, Donald M Arnold
Abstract not available
-
Immigration reform in the USA: health must come first Lancet (IF 168.9) Pub Date : 2023-09-28
Abstract not available
-
COVAX: the unspent billions Lancet (IF 168.9) Pub Date : 2023-09-28 Ann Danaiya Usher
Abstract not available
-
Are we genetically literate enough for global precision health? | Leroy Hood, The Age of Scientific Wellness: Why the Future of Medicine is Personalized, Predictive, Data-Rich, and in Your Hands, Nathan PriceBelknap Press of Harvard University Press (2023), p. 352, US$29·95, £26·95, ISBN: 9780674245945 Lancet (IF 168.9) Pub Date : 2023-09-28 Ambroise Wonkam
Abstract not available
-
The expectations trap in medicine Lancet (IF 168.9) Pub Date : 2023-09-28 Daniel Marchalik
Abstract not available
-
-
Community COVID-19 response in WHO's European region Lancet (IF 168.9) Pub Date : 2023-09-28 Leonardo Palumbo, Camila A Picchio, Catherine Smallwood, Cristiana Salvi, Gerald Rockenschaub
Abstract not available
-
Arcturus (XBB.1.16) COVID-19 subvariant emergence in Indonesia Lancet (IF 168.9) Pub Date : 2023-09-28 Tungki Pratama Umar
Abstract not available
-
Striving to afford free health care in Greece during COVID-19 Lancet (IF 168.9) Pub Date : 2023-09-28 Christos Tsagkaris, Andreas S Papazoglou, Dimitrios V Moysidis, Stavros P Papadakos, Marios Papadakis
Abstract not available
-
Extra data to confirm waning protection of omicron (B.1.1.529) natural immunity Lancet (IF 168.9) Pub Date : 2023-09-28 Maria Elena Flacco, Cecilia Acuti Martellucci, Lamberto Manzoli
Abstract not available
-
Overcoming COVID-19 vaccine hesitancy hurdles Lancet (IF 168.9) Pub Date : 2023-09-28 Chengliang Yang, Linda Lapp, Scott J Tebbutt
Abstract not available
-
Natural SARS-CoV-2 infection-induced immune protection against re-infection Lancet (IF 168.9) Pub Date : 2023-09-28 Claude Matuchansky
Abstract not available
-
COVID toes, newborn blue toes, and prepartum SARS-CoV-2 infection Lancet (IF 168.9) Pub Date : 2023-09-28 Ya Bin Zhou, Zi Gang Xu
Abstract not available
-
-
-
-
Pulmonary embolism with thrombus-in-transit across a patent foramen ovale Lancet (IF 168.9) Pub Date : 2023-09-28 John W Ostrominski, Christine J Wang, Umberto Campia, Jean M Connors, Dirk J Varelmann, Domagoj Mladinov, Mohamed Keshk, Hicham Skali
Abstract not available
-
Balancing healthcare systems’ performance and environmental footprints Nat. Med. (IF 82.9) Pub Date : 2023-09-28
As healthcare systems perform better, their resource footprints have an increasingly negative impact on the environment and health — requiring innovative strategies to break this vicious cycle.
-
Struggling in the heat: what I need to know about my medication BMJ (IF 105.7) Pub Date : 2023-09-29 Stephanie Allan
Stephanie Allan describes how extreme heat induced side effects from the medication she was taking, and how better information could have helped I’m in my mid 30s and have been taking antipsychotic medication for schizophrenia for more than 10 years. When someone is first prescribed an antipsychotic, they are likely to be having a tricky time and potentially in the strange new environment of a hospital
-
A Spartacus moment for public health physicians? BMJ (IF 105.7) Pub Date : 2023-09-29 Carol Brayne, Martin McKee
The General Medical Council’s (GMC) Good Medical Practice sets out the standards required of doctors registered with it. Its latest version will come into force on 30 January 2024.1 Among the changes from previous versions is an addition to the section “Responding to safety risks” that says, “If you have a formal leadership or management role, you must take active steps to create an environment in
-
Delivering climate and nature commitments is crucial for health BMJ (IF 105.7) Pub Date : 2023-09-29 Anandita Pattnaik, Elaine Mulcahy
The UK is one of the world’s most nature depleted countries and at the current rate of decline and slow recovery, the nation will be less biodiverse 10 years from now than it is today.1 This loss of nature, combined with the impacts of climate change, have major implications for human health that need to be taken seriously. A report by the UK Health Alliance on Climate Change describes the loss of
-
What NHS services are migrants entitled to? BMJ (IF 105.7) Pub Date : 2023-09-29 Fatima B. Wurie, Claire Zhang, Yusuf Ciftci, Cherstyn Hurley, Ines Campos-Matos
The UK has experienced a rise in net migration over recent years, with 606 000 migrants arriving in the UK in 2022.1 But are we doing enough to support migrants to access and navigate the health system? While migrants to the UK are less likely to die from the most common causes of death compared with the rest of the population, they are more likely to die of infectious diseases when compared to UK
-
Geoffrey Mottram Durbin BMJ (IF 105.7) Pub Date : 2023-09-29 Andrew Ewer, Anne Durbin
Geoffrey Mottram Durbin (“Geoff”) was born into a family steeped in socialism. His mother studied under Hugh Gaitskell and his father, Evan, was a Labour MP and minister in Atlee’s postwar government, who sadly drowned when Geoff was just 3 years old. Geoff studied medicine at New College, Oxford, and completed his clinical training at University College London. In 1973 he became a research fellow
-
Kenneth George Taylor BMJ (IF 105.7) Pub Date : 2023-09-29 Brian Cooper, Bob Ryder
Kenneth George Taylor was a consultant physician with a special interest in diabetes, endocrinology, and lipid metabolism at Dudley Road (now City) Hospital, Birmingham, from 1981 to 2003. He was a highly respected physician who was a passionate supporter of what was in the best interests of patients and was a determined advocate for a properly funded NHS. At school, he …
-
Geoffrey Malcolm Sykes Scott BMJ (IF 105.7) Pub Date : 2023-09-29 David Thompson
Geoffrey Malcolm Sykes Scott was born in Richmond, the middle child of Malcolm Scott, a lecturer at the Royal Veterinary College, and Patricia Scott, a lecturer in physiology (subsequently professor of nutritional physiology) at the Royal Free Hospital. Educated at St Paul’s School he worked as a laboratory technician at the Hammersmith before taking up his place at the Royal Free. He did his house
-
Derek John Rowlands BMJ (IF 105.7) Pub Date : 2023-09-29 John Rowlands, John Miller, Bernard Clarke, Daniel Keenan
Derek John Rowlands was born in Prescot, Merseyside, to Arthur and Margaret. He and his sister, Margaret, grew up in their family home, a two up two down terraced house in Edward Road, Prescot. His father and most of his uncles worked at the Cable Factory, whereas Derek took an early interest in medicine (possibly boosted by the number of visits he had from the local doctor in his early years). He
-
Brinley Robert Jackson BMJ (IF 105.7) Pub Date : 2023-09-29 Vidan Masani
Brinley Robert Jackson (“Bryn”) was born and raised in Bramhall, Cheshire, and always remained proud of his northern roots. He was educated at Stockport Grammar School where at the age of 18 he met …
-
No, degrowth won’t save us BMJ (IF 105.7) Pub Date : 2023-09-28 Wim Naudé
Smith argues that “perhaps only degrowth can save us” from ecological catastrophe.1 It won’t. Degrowth will make the ecological crisis worse. It is ecological iatrogenics2 or, if you will, economic quackery. The medical profession once fervently believed in bloodletting. Mozart and Beethoven’s deaths, among millions of others, were probably hastened by this treatment. Today, like Florence Nightingale
-
Religion and health: complexities and contradictions BMJ (IF 105.7) Pub Date : 2023-09-29 Nasim Mavaddat, Nahal Mavaddat, Peymané Adab, Shirin Fozdar
We agree with Idler and colleagues’ analysis on the influence of religion on health.1 We believe, however, that the role of religion is much more far-reaching. By virtue of its character building and unifying capacity, religion has the potential to transform people and societies. It empowers individuals to build communities and provides tools for creating just and equitable societies.2 The concept
-
We need irreversible elimination of all stockpiles of nuclear weapons BMJ (IF 105.7) Pub Date : 2023-09-29 Frank E Boulton
Abbasi and colleagues remind the medical community of the humanitarian, ecological, and radiological dangers of nuclear war.1 Since the 11 September attacks investigations have focused on pharmacological measures to counter accidental radiation exposure. Many such measures derive from the management of recipients of allogeneic stem cells while in remission from blood cancers who are prepared with a
-
Morocco earthquake: mitigating the impact on patients with cancer Lancet (IF 168.9) Pub Date : 2023-09-27 Khalid El Bairi, Ouissam Al Jarroudi, Said Afqir
Abstract not available
-
Mortality during migration through the Darién Gap in Panama in 2018–22 Lancet (IF 168.9) Pub Date : 2023-09-26 José V Pachar Lucio, Derek Congram, Carlos Franco-Paredes, Amir M Mohareb, José A Suárez Sancho, Ariel Flores, Geneva Rodríguez, Mónica R Pachar Flores
Abstract not available
-
Women, power, and cancer: a Lancet Commission Lancet (IF 168.9) Pub Date : 2023-09-26 Ophira Ginsburg, Verna Vanderpuye, Ann Marie Beddoe, Nirmala Bhoo-Pathy, Freddie Bray, Carlo Caduff, Narjust Florez, Ibtihal Fadhil, Nazik Hammad, Shirin Heidari, Ishu Kataria, Somesh Kumar, Erica Liebermann, Jenna Moodley, Miriam Mutebi, Deborah Mukherji, Rachel Nugent, Winnie K W So, Enrique Soto-Perez-de-Celis, Karla Unger-Saldaña, Isabelle Soerjomataram
Abstract not available
-
Ceftobiprole for Treatment of Complicated Staphylococcus aureus Bacteremia N. Engl. J. Med. (IF 158.5) Pub Date : 2023-09-27 Thomas L. Holland, Sara E. Cosgrove, Sarah B. Doernberg, Timothy C. Jenkins, Nicholas A. Turner, Helen W. Boucher, Oleksander Pavlov, Ivan Titov, Serhii Kosulnykov, Boyko Atanasov, Ivan Poromanski, Manana Makhviladze, Anastasia Anderzhanova, Martin E. Stryjewski, Maziar Assadi Gehr, Marc Engelhardt, Kamal Hamed, Daniel Ionescu, Mark Jones, Mikael Saulay, Jennifer Smart, Harald Seifert, Vance G. Fowler
Background Ceftobiprole is a cephalosporin that may be effective for treating complicated Staphylococcus aureus bacteremia, including methicillin-resistant S. aureus. Methods In this phase 3, double-blind, double-dummy, noninferiority trial, adults with complicated S. aureus bacteremia were randomly assigned in a 1:1 ratio to receive ceftobiprole at a dose of 500 mg intravenously every 6 hours for
-
Artificial Intelligence in Molecular Medicine N. Engl. J. Med. (IF 158.5) Pub Date : 2023-09-28
To the Editor: The review article by Gomes and Ashley (June 29 issue)1 highlights how artificial intelligence, especially deep learning, can be applied to the analysis of complex, high-dimensional omics data. However, the integration of multiple types of omics data in a meaningful way by the application of complex machine learning and statistical modeling remains an open challenge in precision medicine
-
An Alternate Explanation N. Engl. J. Med. (IF 158.5) Pub Date : 2023-09-28
To the Editor: In their Clinical Problem-Solving case, Alsaigh et al. (April 6 issue)1 describe a man in whom they diagnosed arterial calcification caused by deficiency of CD73 (ACDC), which was attributed to the homozygous NT5E variant c.1126A→G p.(Thr376Ala).2 We think this variant should be assessed with caution. The application of the guidelines of the American College of Medical Genetics and Genomics
-
Antibody NI006 for Cardiac Transthyretin Amyloid Depletion N. Engl. J. Med. (IF 158.5) Pub Date : 2023-09-28
To the Editor: Garcia-Pavia et al. (July 20 issue)1 report evidence from the phase 1 trial of the recombinant human antibody NI006 for transthyretin amyloid (ATTR) cardiomyopathy and heart failure, in which the treatment led to reductions in imaging-based surrogate markers of cardiac amyloid load. The transthyretin stabilizer tafamidis improves outcomes but does not prevent disease progression.2,3
-
Bulevirtide for Chronic Hepatitis D N. Engl. J. Med. (IF 158.5) Pub Date : 2023-09-28
To the Editor: With regard to the trial by Wedemeyer et al. (July 6 issue),1 we are concerned that although bulevirtide may be effective in reducing hepatitis D virus (HDV) RNA levels and hepatic inflammation, it may not affect the course of hepatitis B virus (HBV) infection or reduce the HBV surface antigen level, thereby leaving a critical aspect of the disease unaddressed. Since HDV cannot survive
-
Efficacy and Safety of Encaleret in Autosomal Dominant Hypocalcemia Type 1 N. Engl. J. Med. (IF 158.5) Pub Date : 2023-09-28 Rachel I. Gafni, Iris R. Hartley, Kelly L. Roszko, Edward F. Nemeth, Karen A. Pozo, Ed Lombardi, Ananth V. Sridhar, Mary S. Roberts, Jonathan C. Fox, Michael T. Collins
This letter describes 13 patients with hypoparathyroidism caused by autosomal dominant hypocalcemia type 1 in whom the investigational oral calcilytic encaleret restored physiologic mineral homeostasis.
-
Antiracist Documentation Practices — Shaping Clinical Encounters and Decision Making N. Engl. J. Med. (IF 158.5) Pub Date : 2023-09-28 J. Corey Williams, Ashley Andreou, Enrico G. Castillo, Joshua Neff, Matthew Goldenberg, Courtney R. Lee, Jaya Aysola, Robert Rohrbaugh, Jessica Isom
Research suggests that documentation can actually influence clinical decision making. The normative use of race in documentation therefore demands interrogation.
-
Glucose Control in the ICU N. Engl. J. Med. (IF 158.5) Pub Date : 2023-09-28 Guillermo E. Umpierrez
Randomized, controlled trials aiming for near-normal glycemic targets (80 to 110 mg per deciliter [4.4 to 6.1 mmol per liter]) in critically ill patients have shown conflicting data regarding the benefits of intensive glycemic control (Table 1). In 2001, Van den Berghe et al. reported a dramatic 42% lower mortality among patients in the surgical intensive care unit (ICU) in whom the blood glucose level
-
Harnessing the Deluge of Rhythm-Monitoring Data for the Prevention of Stroke N. Engl. J. Med. (IF 158.5) Pub Date : 2023-09-28 Peter H. Stone, William H. Sauer
Stroke that is related to atrial fibrillation is particularly debilitating and potentially lethal because of the size of the embolism that is caused by a left atrial thrombus. Therefore, the identification of asymptomatic atrial fibrillation and the subsequent initiation of anticoagulant therapy could translate into better outcomes for affected patients. Screening for paroxysmal atrial fibrillation
-
Case 30-2023: A 50-Year-Old Woman with Confusion N. Engl. J. Med. (IF 158.5) Pub Date : 2023-09-28 Amulya Nagarur, Theodore T. Pierce, Andrew Z. Fenves, Elan R. Witkowski, Nina B. Gold
A 50-year-old woman with a history of Roux-en-Y gastric bypass presented with confusion. She had anasarca and an albumin level of 1.9 g per deciliter (reference range, 3.3 to 5.0). A diagnosis was made.
-
“Photographic Negative of Pulmonary Edema” in Chronic Eosinophilic Pneumonia N. Engl. J. Med. (IF 158.5) Pub Date : 2023-09-28 Basim Ali, Matthew C. Mason
-
Where Medical Statistics Meets Artificial Intelligence N. Engl. J. Med. (IF 158.5) Pub Date : 2023-09-28 David J. Hunter, Christopher Holmes
Challenges at the interface of medical statistics and AI are population inference vs. prediction, generalizability, reproducibility and interpretation of evidence, and stability and statistical guarantees.
-
Death after High-Dose rAAV9 Gene Therapy in a Patient with Duchenne’s Muscular Dystrophy N. Engl. J. Med. (IF 158.5) Pub Date : 2023-09-28 Angela Lek, Brenda Wong, Allison Keeler, Meghan Blackwood, Kaiyue Ma, Shushu Huang, Katelyn Sylvia, A. Rita Batista, Rebecca Artinian, Danielle Kokoski, Shestruma Parajuli, Juan Putra, C. Katte Carreon, Hart Lidov, Keryn Woodman, Sander Pajusalu, Janelle M. Spinazzola, Thomas Gallagher, Joan LaRovere, Diane Balderson, Lauren Black, Keith Sutton, Richard Horgan, Monkol Lek, Terence Flotte
We treated a 27-year-old patient with Duchenne’s muscular dystrophy (DMD) with recombinant adeno-associated virus (rAAV) serotype 9 containing dSaCas9 (i.e., “dead” Staphylococcus aureus Cas9, in which the Cas9 nuclease activity has been inactivated) fused to VP64; this transgene was designed to up-regulate cortical dystrophin as a custom CRISPR–transactivator therapy. The dose of rAAV used was 1×1014
-
Increasing Prevalence of Artemisinin-Resistant HRP2-Negative Malaria in Eritrea N. Engl. J. Med. (IF 158.5) Pub Date : 2023-09-28 Selam Mihreteab, Lucien Platon, Araia Berhane, Barbara H. Stokes, Marian Warsame, Pascal Campagne, Alexis Criscuolo, Laurence Ma, Nathalie Petiot, Cécile Doderer-Lang, Eric Legrand, Kurt E. Ward, Assefash Zehaie Kassahun, Pascal Ringwald, David A. Fidock, Didier Ménard
Although the clinical efficacy of antimalarial artemisinin-based combination therapies in Africa remains high, the recent emergence of partial resistance to artemisinin in Plasmodium falciparum on the continent is troubling, given the lack of alternative treatments.
-
Tight Blood-Glucose Control without Early Parenteral Nutrition in the ICU N. Engl. J. Med. (IF 158.5) Pub Date : 2023-09-28 Jan Gunst, Yves Debaveye, Fabian Güiza, Jasperina Dubois, Astrid De Bruyn, Dieter Dauwe, Erwin De Troy, Michael P. Casaer, Greet De Vlieger, Renata Haghedooren, Bart Jacobs, Geert Meyfroidt, Catherine Ingels, Jan Muller, Dirk Vlasselaers, Lars Desmet, Liese Mebis, Pieter J. Wouters, Björn Stessel, Laurien Geebelen, Jeroen Vandenbrande, Michiel Brands, Ine Gruyters, Ester Geerts, Ilse De Pauw, Joris
Background Randomized, controlled trials have shown both benefit and harm from tight blood-glucose control in patients in the intensive care unit (ICU). Variation in the use of early parenteral nutrition and in insulin-induced severe hypoglycemia might explain this inconsistency. Methods Download a PDF of the Research Summary. We randomly assigned patients, on ICU admission, to liberal glucose control
-
Artemisinin-Resistant and HRP-Negative Malaria Parasites in Africa N. Engl. J. Med. (IF 158.5) Pub Date : 2023-09-28 Brian Greenwood
The first two decades of this century saw substantial progress in the control of malaria: deaths from malaria fell by one half, and over the past 10 years, 15 countries have been certified by the World Health Organization as being malaria-free. This success has been achieved by means of the scale-up of effective methods of diagnosis, treatment, chemoprevention, and vector control. Unfortunately, this