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A new pathway for primary aldosteronism treatment Lancet (IF 98.4) Pub Date : 2025-02-07 Alexander A Leung, Gregory Kline
No Abstract
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Health-care system adaptability during wildfire disasters: crucial insights from LA County Lancet (IF 98.4) Pub Date : 2025-02-07 Attila J Hertelendy, Jeremy Maggin, Gregory R Ciottone
No Abstract
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Endoscopic, ultrasound-guided, radiofrequency ablation of aldosterone-producing adenomas (FABULAS): a UK, multicentre, prospective, proof-of-concept trial Lancet (IF 98.4) Pub Date : 2025-02-07 Giulia Argentesi, Xilin Wu, Alexander Ney, Emily Goodchild, Kate Laycock, Yun-Ni Lee, Russell Senanayake, James MacFarlane, Elisabeth Ng, Jessica Kearney, Sam O'Toole, Jackie Salsbury, Nick Carroll, Daniel Gillett, John A Tadross, Alison Marker, Edmund M Godfrey, George Goodchild, Jonathan P Bestwick, Mark Gurnell, Patrick Wilson
BackgroundUnilateral aldosterone-producing adrenal adenomas (APAs) are the potentially curable cause of 5% of all cases of hypertension. Their localisation (via adrenal vein sampling [AVS]) and removal (by laparoscopic adrenalectomy) require invasive procedures that are unattractive to patients. Molecular imaging-located, endoscopic ultrasound-guided trans-gastric radiofrequency ablation (EUS-RFA)
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Angola's cholera outbreak: a wake-up call for global action Lancet (IF 98.4) Pub Date : 2025-02-07 Mauer Alexandre da Ascensão Gonçalves, Howard Lopes Ribeiro Júnior
No Abstract
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PEPFAR under review: what's at stake for PEPFAR's future Lancet (IF 98.4) Pub Date : 2025-02-07 Jirair Ratevosian, Gregorio Millett, Brian Honermann, Sara Bennett, Catherine Connor, Linda-Gail Bekker, Chris Beyrer
No Abstract
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Gender removal by fiat: impacts of new Trump administration edicts Lancet (IF 98.4) Pub Date : 2025-02-07 Nancy Krieger, Sofia Gruskin
No Abstract
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The visible and hidden mortality caused by flooding Nat. Med. (IF 58.7) Pub Date : 2025-02-07 Andrew P. Morse
A study advances our understanding of how different flood events affect direct and indirect causes of mortality — providing useful insights for disaster response and preparedness.
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A new gut–brain therapeutic target for hepatic encephalopathy Nat. Med. (IF 58.7) Pub Date : 2025-02-07 Patricia P. Bloom
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Allogeneic approach unlocks CAR T cell benefits in solid tumors Nat. Med. (IF 58.7) Pub Date : 2025-02-07 Rozalyn Chok, Sneha Ramakrishna
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Confounding by familial factors influences the associations between maternal health and autism Nat. Med. (IF 58.7) Pub Date : 2025-02-07
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CAR-macrophage therapy for HER2-overexpressing advanced solid tumors: a phase 1 trial Nat. Med. (IF 58.7) Pub Date : 2025-02-07 Kim A. Reiss, Mathew G. Angelos, E. Claire Dees, Yuan Yuan, Naoto T. Ueno, Paula R. Pohlmann, Melissa L. Johnson, Joseph Chao, Olga Shestova, Jonathan S. Serody, Maggie Schmierer, Madison Kremp, Michael Ball, Rehman Qureshi, Benjamin H. Schott, Poonam Sonawane, Sabrina Ceeraz DeLong, Melissa Christiano, Ramona F. Swaby, Sascha Abramson, Ken Locke, Debora Barton, Eugene Kennedy, Saar Gill, Daniel Cushing
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Symptom monitoring with electronic patient-reported outcomes during cancer treatment: final results of the PRO-TECT cluster-randomized trial Nat. Med. (IF 58.7) Pub Date : 2025-02-07 Ethan Basch, Deborah Schrag, Jennifer Jansen, Sydney Henson, Brenda Ginos, Angela M. Stover, Philip Carr, Patricia A. Spears, Mattias Jonsson, Allison M. Deal, Antonia V. Bennett, Gita Thanarajasingam, Lauren Rogak, Bryce B. Reeve, Claire Snyder, Deborah Bruner, David Cella, Lisa A. Kottschade, Jane Perlmutter, Cindy Geoghegan, Barbara Given, Gina L. Mazza, Robert Miller, Jon F. Strasser, Dylan M.
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Telemedicine-supported lifestyle intervention for glycemic control in patients with CHD and T2DM: multicenter, randomized controlled trial Nat. Med. (IF 58.7) Pub Date : 2025-02-07 Stephan Mueller, Sophia M. T. Dinges, Felix Gass, Isabel Fegers-Wustrow, Julian Treitschke, Pia von Korn, Alessandra Boscheri, Janosch Krotz, Felix Freigang, Clara Dubois, Ephraim B. Winzer, Axel Linke, Frank Edelmann, Anna Feuerstein, Oliver Wolfram, Kerstin Schäfer, Marlo Verket, Bernd Wolfarth, Marcus Dörr, Rolf Wachter, Björn Hackenberg, Sarah Rust, Thomas Nebling, Volker Amelung, Martin Halle
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American chaos: standing up for health and medicine Lancet (IF 98.4) Pub Date : 2025-02-06
No Abstract
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On the quantification of military violence in Gaza Lancet (IF 98.4) Pub Date : 2025-02-06 James Smith, Duha Shellah, Zoé Samudzi
No Abstract
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Effect of normobaric hyperoxia in ischaemic stroke Lancet (IF 98.4) Pub Date : 2025-02-06 Diederik W J Dippel, Paula M Janssen
No Abstract
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Offline: Equality must be defended Lancet (IF 98.4) Pub Date : 2025-02-06 Richard Horton
No Abstract
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Trump agenda ignites legal challenges Lancet (IF 98.4) Pub Date : 2025-02-06 Susan Jaffe
No Abstract
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Health worker lay-offs in east Africa following US aid freeze Lancet (IF 98.4) Pub Date : 2025-02-06 Gilbert Nakweya
No Abstract
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Ukraine HIV services severely curtailed by US aid freeze Lancet (IF 98.4) Pub Date : 2025-02-06 Ed Holt
No Abstract
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Marcus Lacerda: aiming to eliminate vivax malaria Lancet (IF 98.4) Pub Date : 2025-02-06 Tony Kirby
No Abstract
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The rise of agentic AI teammates in medicine Lancet (IF 98.4) Pub Date : 2025-02-06 James Zou, Eric J Topol
No Abstract
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Health, rights, and work on the margins Lancet (IF 98.4) Pub Date : 2025-02-06 Sarah Boseley
No Abstract
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Faustine Ndugulile Lancet (IF 98.4) Pub Date : 2025-02-06 Andrew Green
Download: Download high-res image (274KB) Download: Download full-size image
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Attacks on reproductive rights in Brazil Lancet (IF 98.4) Pub Date : 2025-02-06 Carlos Abraão Moura Valpassos, Stephania Gonçalves Klujsza, Jason Bartholomew Scott
No Abstract
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A health emergency: Afghanistan's nursing and midwifery ban Lancet (IF 98.4) Pub Date : 2025-02-06 Alaha Nasari, Sammer Marzouk, Najibullah Safi
No Abstract
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More physicians needed for more hope in South Korea Lancet (IF 98.4) Pub Date : 2025-02-06 Byung Uk Lee
No Abstract
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Comprehensive response to mpox in Pakistan Lancet (IF 98.4) Pub Date : 2025-02-06 Massab Umair, Muhammad Salman
No Abstract
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Unit 731 and history-informed professional identity formation Lancet (IF 98.4) Pub Date : 2025-02-06 Zohar Lederman, Lam Hin Lai Ivan, Cheuk Nam Liu, Aaron Hames, Jerry Menikoff
No Abstract
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Department of Error Lancet (IF 98.4) Pub Date : 2025-02-06
Kudo M, Ren Z, Guo Y, et al. Transarterial chemoembolisation combined with lenvatinib plus pembrolizumab versus dual placebo for unresectable, non-metastatic hepatocellular carcinoma (LEAP-012): a multicentre, randomised, double-blind, phase 3 study. Lancet 2025; 405: 203–15. The appendix of this Article has been corrected as of Feb 6, 2025.
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Department of Error Lancet (IF 98.4) Pub Date : 2025-02-06
St Peter SD, Noel-MacDonnell JR, Hall NJ, et al. Appendicectomy versus antibiotics for acute uncomplicated appendicitis in children: an open-label, international, multicentre, randomised, non-inferiority trial. Lancet 2025; 405: 233–40—In this Article, Prof Simon Eaton's affiliation should have been “UCL Great Ormond Street Institute of Child Health, London, UK”. This correction has been made to the
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Department of Error Lancet (IF 98.4) Pub Date : 2025-02-06
McCormack M, Eminowicz G, Gallardo D, et al. Induction chemotherapy followed by standard chemoradiotherapy versus standard chemoradiotherapy alone in patients with locally advanced cervical cancer (GCIG INTERLACE): an international, multicentre, randomised phase 3 trial. Lancet 2024; 404: 1525–35—The appendix of this Article has been corrected as of Feb 6, 2025.
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Department of Error Lancet (IF 98.4) Pub Date : 2025-02-06
Jamaluddine Z, Abukmail H, Aly S, Campbell OMR, Checchi F. Traumatic injury mortality in the Gaza Strip from Oct 7, 2023, to June 30, 2024: a capture–recapture analysis. Lancet 2025; 405: 469–77—The appendix of this Article has been corrected to fix labelling discrepancies. This correction has been made as of Feb 6, 2025.
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Normobaric hyperoxia combined with endovascular treatment for acute ischaemic stroke in China (OPENS-2 trial): a multicentre, randomised, single-blind, sham-controlled trial Lancet (IF 98.4) Pub Date : 2025-02-06 Weili Li, Jing Lan, Ming Wei, Lan Liu, Chengbei Hou, Zhifeng Qi, Chuanhui Li, Liqun Jiao, Qi Yang, Wenhuo Chen, Shuling Liu, Xincan Yue, Qinglin Dong, Haicheng Yuan, Zongen Gao, Xiangbin Wu, Changming Wen, Tong Li, Changchun Jiang, Di Li, Jing Zhou
BackgroundEndovascular treatment improves the recanalisation rate for patients with acute ischaemic stroke; however, even with endovascular treatment, approximately half of patients do not have a favourable functional outcome. We aimed to evaluate the effect of normobaric hyperoxia combined with endovascular treatment on functional outcomes up to 90 days after treatment in patients who had an acute
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Pregnancy and the liver Lancet (IF 98.4) Pub Date : 2025-02-06 Mussarat N Rahim, Catherine Williamson, Nikos A Kametas, Michael A Heneghan
Some of the physiological changes that occur in pregnancy manifest in the liver. These alterations might exacerbate or improve some pre-existent liver diseases, while many conditions remain unaffected. Some hepatic manifestations during pregnancy are secondary to disorders unique to pregnancy. Due to improved management of chronic conditions and assisted conception methods, pregnancies in people with
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Author Correction: Mutations in ACTRT1 and its enhancer RNA elements lead to aberrant activation of Hedgehog signaling in inherited and sporadic basal cell carcinomas Nat. Med. (IF 58.7) Pub Date : 2025-02-06 Elodie Bal, Hyun-Sook Park, Zakia Belaid-Choucair, Hülya Kayserili, Magali Naville, Marine Madrange, Elena Chiticariu, Smail Hadj-Rabia, Nicolas Cagnard, Francois Kuonen, Daniel Bachmann, Marcel Huber, Cindy Le Gall, Francine Côté, Sylvain Hanein, Rasim Özgür Rosti, Ayca Dilruba Aslanger, Quinten Waisfisz, Christine Bodemer, Olivier Hermine, Fanny Morice-Picard, Bruno Labeille, Frédéric Caux, Juliette
Correction to: Nature Medicinehttps://doi.org/10.1038/nm.4368, published online 4 September 2017.
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Permanent Contraception Procedures Increase Among Young Adults Post Dobbs. JAMA (IF 63.1) Pub Date : 2025-02-07 Samantha Anderer
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Dementia Cases Expected to Nearly Double in the US by 2060. JAMA (IF 63.1) Pub Date : 2025-02-07 Samantha Anderer
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Systematic Review Examines GLP-1 Drugs' Effectiveness and Safety in Patients Without Diabetes. JAMA (IF 63.1) Pub Date : 2025-02-07 Samantha Anderer
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Global Study Reveals High Rates of Sexual Violence Against Children. JAMA (IF 63.1) Pub Date : 2025-02-07 Samantha Anderer
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Landmark Study Aims to Enroll 100 000 Black Women to Investigate Their Cancer Risks and Outcomes JAMA (IF 63.1) Pub Date : 2025-02-07 Anna Bock
This Medical News article discusses the American Cancer Society’s VOICES of Black Women population cohort study, the largest ever study of Black women in the US.
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Drinking Alcohol Causes Certain Cancers, So Why Don’t Labels Warn About That? JAMA (IF 63.1) Pub Date : 2025-02-07 Rita Rubin
This Medical News article discusses updating health warning labels on alcoholic beverages to include the fact that drinking alcohol causes certain cancers, with examples of initiatives in Canada, Ireland, and South Korea.
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Study Finds Most Older Adults Use Digital Health Technologies, Plus Some Surprises JAMA (IF 63.1) Pub Date : 2025-02-07 Roy Perlis, Kate Schweitzer
This Medical News article is an interview with Cornelius A. James, MD, of the University of Michigan Medical School about his recent research examining the use of digital health technologies, including patient portals, among older US adults and how it relates to his own experience in the clinic.
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New neurons are born in the adult human brain Nat. Med. (IF 58.7) Pub Date : 2025-02-06
Rusty Gage describes how evidence for neurogenesis in the adult human hippocampus shaped our understanding of learning, memory and mental health.
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The MI-CLAIM-GEN checklist for generative artificial intelligence in health Nat. Med. (IF 58.7) Pub Date : 2025-02-06 Brenda Y. Miao, Irene Y. Chen, Christopher Y. K. Williams, Jaysón Davidson, Augusto Garcia-Agundez, Shenghuan Sun, Travis Zack, Suchi Saria, Rima Arnaout, Giorgio Quer, Hossein J. Sadaei, Ali Torkamani, Brett Beaulieu-Jones, Bin Yu, Milena Gianfrancesco, Atul J. Butte, Beau Norgeot, Madhumita Sushil
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Author Correction: Sustained aviremia despite anti-retroviral therapy non-adherence in male children after in utero HIV transmission Nat. Med. (IF 58.7) Pub Date : 2025-02-05 Nomonde Bengu, Gabriela Cromhout, Emily Adland, Katya Govender, Nicholas Herbert, Nicholas Lim, Rowena Fillis, Kenneth Sprenger, Vinicius Vieira, Samantha Kannie, Jeroen van Lobenstein, Kogielambal Chinniah, Constant Kapongo, Roopesh Bhoola, Malini Krishna, Noxolo Mchunu, Giuseppe Rubens Pascucci, Nicola Cotugno, Paolo Palma, Alfredo Tagarro, Pablo Rojo, Julia Roider, Maria C. Garcia-Guerrero, Christina
Correction to: Nature Medicine https://doi.org/10.1038/s41591-024-03105-4, published online 6 June 2024.
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Efficacy of Zenocutuzumab in NRG1 Fusion-Positive Cancer. N. Engl. J. Med. (IF 96.2) Pub Date : 2025-02-06 Alison M Schram,Koichi Goto,Dong-Wan Kim,Teresa Macarulla,Antoine Hollebecque,Eileen M O'Reilly,Sai-Hong Ignatius Ou,Jordi Rodon,Sun Young Rha,Kazumi Nishino,Michaël Duruisseaux,Joon Oh Park,Cindy Neuzillet,Stephen V Liu,Benjamin A Weinberg,James M Cleary,Emiliano Calvo,Kumiko Umemoto,Misako Nagasaka,Christoph Springfeld,Tanios Bekaii-Saab,Grainne M O'Kane,Frans Opdam,Kim A Reiss,Andrew K Joe,Ernesto
BACKGROUND Neuregulin 1 (NRG1) fusions are recurrent oncogenic drivers found in multiple solid tumors. NRG1 binds to human epidermal growth factor receptor 3 (HER3), leading to heterodimerization with HER2 and activation of downstream growth and proliferation pathways. The efficacy and safety of zenocutuzumab, a bispecific antibody against HER2 and HER3, in patients with NRG1 fusion-positive solid
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Plaques en Prairie Fauchée Tongue Lesions in Secondary Syphilis. N. Engl. J. Med. (IF 96.2) Pub Date : 2025-02-06 Jonathan P Angel
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Identifying and Targeting TNF Signaling in Idiopathic Multicentric Castleman's Disease. N. Engl. J. Med. (IF 96.2) Pub Date : 2025-02-06 Melanie D Mumau,Michael V Gonzalez,Chunyu Ma,Abiola H Irvine,Mateo Sarmiento Bustamante,Saishravan Shyamsundar,Luke Y C Chen,David Koslicki,David C Fajgenbaum
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CD4+ T-Cell Lymphoma Harboring a Chimeric Antigen Receptor Integration in TP53. N. Engl. J. Med. (IF 96.2) Pub Date : 2025-02-06 Karlo Perica,Nayan Jain,Michael Scordo,Ruchi Patel,Ozgur Can Eren,Utsav Patel,Gunes Gundem,Dylan Domenico,Sneha Mitra,Nicholas D Socci,John K Everett,Aoife M Roche,Angelina Petrichenko,Gunjan L Shah,Maria E Arcila,Laetitia Borsu,Jae H Park,Steven M Horwitz,Sergio A Giralt,Ahmet Dogan,Christina Leslie,Elli Papaemmanuil,Frederic D Bushman,Saad Z Usmani,Michel Sadelain,Sham Mailankody
Malignant T-cell transformation after chimeric antigen receptor (CAR) T-cell therapy has been described, but the contribution of CAR integration to oncogenesis is not clear. Here we report a case of a T-cell lymphoma harboring a lentiviral integration in a known tumor suppressor, TP53, which developed in a patient with multiple myeloma after B-cell maturation antigen (BCMA) CAR T-cell therapy.
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Perioperative Durvalumab in Bladder Cancer. N. Engl. J. Med. (IF 96.2) Pub Date : 2025-02-06 Shunsuke Koga,Lin Mei
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Social factors are crucial to encouraging physical activity. BMJ (IF 93.6) Pub Date : 2025-02-06 Lisa McNally
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As a medical intern in Gaza, I have stepped out of the classroom and onto the front line. BMJ (IF 93.6) Pub Date : 2025-02-06 Hosam Shaikhkhalil
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Should we consider a "three strikes and you're in" rule in general practice? BMJ (IF 93.6) Pub Date : 2025-02-06 Rebecca Rosen
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The BMJ appeal 2024-25: Faces of conflict in Gaza. BMJ (IF 93.6) Pub Date : 2025-02-06 Caitlin Shortall
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Valdo Calocane's dislike of needles left him unmedicated for schizophrenia, finds report. BMJ (IF 93.6) Pub Date : 2025-02-06 Clare Dyer
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Hospitals are urged to learn from case of delayed cancer diagnosis after failure to follow up. BMJ (IF 93.6) Pub Date : 2025-02-06 Matthew Limb