Black residents face higher rates of remedial interventions and dismissal than do their White counterparts. Such overpolicing affects the mental health of trainees as well as their careers.

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The 1972 Poisons Act was introduced to enable registered pharmacists, under the aegis of the Royal Pharmaceutical Society, to regulate the sale of non-medicinal poisons and subsequently of explosives precursors. Since then it has undergone several amendments, the latest of which is about to come into force (on 1 October 2023), under The Control of Poisons and Explosives Precursors Regulations 2023

Leila Lessof, former director of Public Health Islington and Parkside Health Authority, has died at the age of 89. She was born into a Jewish medical family in London, to Lionel Liebster, a GP in Tottenham, and Renee (née Segolov). Her grandfather, Leopold, also a doctor, came to London from Vienna, to escape antisemitism and had to requalify at the Royal London Hospital before he could practise in

Leila and Maurice Lessof Maurice Lessof, clinical immunologist; emeritus professor of medicine, King’s, Guy’s, and St Thomas’ hospitals; and chairman of Lewisham Hospitals NHS Trust, has died at the age of 99. Lessof was born in London, the son of Noah Lessof and Fanny (née Slonim). He grew up in Clapton, east London, with his sister, Elizabeth, on the same street as all his cousins. As the only boy

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Background Primary immune thrombocytopenia is an autoimmune disorder mediated partly by platelet autoantibodies, resulting in thrombocytopenia, bleeding, and constitutional symptoms. Efgartigimod, a first-in-class novel human IgG1 Fc fragment, binds the neonatal Fc receptor with high affinity and thus reduces serum IgG concentrations, including autoantibodies. The objective of this study was to evaluate

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As healthcare systems perform better, their resource footprints have an increasingly negative impact on the environment and health — requiring innovative strategies to break this vicious cycle.

Stephanie Allan describes how extreme heat induced side effects from the medication she was taking, and how better information could have helped I’m in my mid 30s and have been taking antipsychotic medication for schizophrenia for more than 10 years. When someone is first prescribed an antipsychotic, they are likely to be having a tricky time and potentially in the strange new environment of a hospital

The General Medical Council’s (GMC) Good Medical Practice sets out the standards required of doctors registered with it. Its latest version will come into force on 30 January 2024.1 Among the changes from previous versions is an addition to the section “Responding to safety risks” that says, “If you have a formal leadership or management role, you must take active steps to create an environment in

The UK is one of the world’s most nature depleted countries and at the current rate of decline and slow recovery, the nation will be less biodiverse 10 years from now than it is today.1 This loss of nature, combined with the impacts of climate change, have major implications for human health that need to be taken seriously. A report by the UK Health Alliance on Climate Change describes the loss of

The UK has experienced a rise in net migration over recent years, with 606 000 migrants arriving in the UK in 2022.1 But are we doing enough to support migrants to access and navigate the health system? While migrants to the UK are less likely to die from the most common causes of death compared with the rest of the population, they are more likely to die of infectious diseases when compared to UK

Geoffrey Mottram Durbin (“Geoff”) was born into a family steeped in socialism. His mother studied under Hugh Gaitskell and his father, Evan, was a Labour MP and minister in Atlee’s postwar government, who sadly drowned when Geoff was just 3 years old. Geoff studied medicine at New College, Oxford, and completed his clinical training at University College London. In 1973 he became a research fellow

Kenneth George Taylor was a consultant physician with a special interest in diabetes, endocrinology, and lipid metabolism at Dudley Road (now City) Hospital, Birmingham, from 1981 to 2003. He was a highly respected physician who was a passionate supporter of what was in the best interests of patients and was a determined advocate for a properly funded NHS. At school, he …

Geoffrey Malcolm Sykes Scott was born in Richmond, the middle child of Malcolm Scott, a lecturer at the Royal Veterinary College, and Patricia Scott, a lecturer in physiology (subsequently professor of nutritional physiology) at the Royal Free Hospital. Educated at St Paul’s School he worked as a laboratory technician at the Hammersmith before taking up his place at the Royal Free. He did his house

Derek John Rowlands was born in Prescot, Merseyside, to Arthur and Margaret. He and his sister, Margaret, grew up in their family home, a two up two down terraced house in Edward Road, Prescot. His father and most of his uncles worked at the Cable Factory, whereas Derek took an early interest in medicine (possibly boosted by the number of visits he had from the local doctor in his early years). He

Brinley Robert Jackson (“Bryn”) was born and raised in Bramhall, Cheshire, and always remained proud of his northern roots. He was educated at Stockport Grammar School where at the age of 18 he met …

Smith argues that “perhaps only degrowth can save us” from ecological catastrophe.1 It won’t. Degrowth will make the ecological crisis worse. It is ecological iatrogenics2 or, if you will, economic quackery. The medical profession once fervently believed in bloodletting. Mozart and Beethoven’s deaths, among millions of others, were probably hastened by this treatment. Today, like Florence Nightingale

We agree with Idler and colleagues’ analysis on the influence of religion on health.1 We believe, however, that the role of religion is much more far-reaching. By virtue of its character building and unifying capacity, religion has the potential to transform people and societies. It empowers individuals to build communities and provides tools for creating just and equitable societies.2 The concept

Abbasi and colleagues remind the medical community of the humanitarian, ecological, and radiological dangers of nuclear war.1 Since the 11 September attacks investigations have focused on pharmacological measures to counter accidental radiation exposure. Many such measures derive from the management of recipients of allogeneic stem cells while in remission from blood cancers who are prepared with a

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Background Ceftobiprole is a cephalosporin that may be effective for treating complicated Staphylococcus aureus bacteremia, including methicillin-resistant S. aureus. Methods In this phase 3, double-blind, double-dummy, noninferiority trial, adults with complicated S. aureus bacteremia were randomly assigned in a 1:1 ratio to receive ceftobiprole at a dose of 500 mg intravenously every 6 hours for

To the Editor: The review article by Gomes and Ashley (June 29 issue)1 highlights how artificial intelligence, especially deep learning, can be applied to the analysis of complex, high-dimensional omics data. However, the integration of multiple types of omics data in a meaningful way by the application of complex machine learning and statistical modeling remains an open challenge in precision medicine

To the Editor: In their Clinical Problem-Solving case, Alsaigh et al. (April 6 issue)1 describe a man in whom they diagnosed arterial calcification caused by deficiency of CD73 (ACDC), which was attributed to the homozygous NT5E variant c.1126A→G p.(Thr376Ala).2 We think this variant should be assessed with caution. The application of the guidelines of the American College of Medical Genetics and Genomics

To the Editor: Garcia-Pavia et al. (July 20 issue)1 report evidence from the phase 1 trial of the recombinant human antibody NI006 for transthyretin amyloid (ATTR) cardiomyopathy and heart failure, in which the treatment led to reductions in imaging-based surrogate markers of cardiac amyloid load. The transthyretin stabilizer tafamidis improves outcomes but does not prevent disease progression.2,3

To the Editor: With regard to the trial by Wedemeyer et al. (July 6 issue),1 we are concerned that although bulevirtide may be effective in reducing hepatitis D virus (HDV) RNA levels and hepatic inflammation, it may not affect the course of hepatitis B virus (HBV) infection or reduce the HBV surface antigen level, thereby leaving a critical aspect of the disease unaddressed. Since HDV cannot survive

This letter describes 13 patients with hypoparathyroidism caused by autosomal dominant hypocalcemia type 1 in whom the investigational oral calcilytic encaleret restored physiologic mineral homeostasis.

Research suggests that documentation can actually influence clinical decision making. The normative use of race in documentation therefore demands interrogation.

Randomized, controlled trials aiming for near-normal glycemic targets (80 to 110 mg per deciliter [4.4 to 6.1 mmol per liter]) in critically ill patients have shown conflicting data regarding the benefits of intensive glycemic control (Table 1). In 2001, Van den Berghe et al. reported a dramatic 42% lower mortality among patients in the surgical intensive care unit (ICU) in whom the blood glucose level

Stroke that is related to atrial fibrillation is particularly debilitating and potentially lethal because of the size of the embolism that is caused by a left atrial thrombus. Therefore, the identification of asymptomatic atrial fibrillation and the subsequent initiation of anticoagulant therapy could translate into better outcomes for affected patients. Screening for paroxysmal atrial fibrillation

A 50-year-old woman with a history of Roux-en-Y gastric bypass presented with confusion. She had anasarca and an albumin level of 1.9 g per deciliter (reference range, 3.3 to 5.0). A diagnosis was made.

Challenges at the interface of medical statistics and AI are population inference vs. prediction, generalizability, reproducibility and interpretation of evidence, and stability and statistical guarantees.

We treated a 27-year-old patient with Duchenne’s muscular dystrophy (DMD) with recombinant adeno-associated virus (rAAV) serotype 9 containing dSaCas9 (i.e., “dead” Staphylococcus aureus Cas9, in which the Cas9 nuclease activity has been inactivated) fused to VP64; this transgene was designed to up-regulate cortical dystrophin as a custom CRISPR–transactivator therapy. The dose of rAAV used was 1×1014

Although the clinical efficacy of antimalarial artemisinin-based combination therapies in Africa remains high, the recent emergence of partial resistance to artemisinin in Plasmodium falciparum on the continent is troubling, given the lack of alternative treatments.

Background Randomized, controlled trials have shown both benefit and harm from tight blood-glucose control in patients in the intensive care unit (ICU). Variation in the use of early parenteral nutrition and in insulin-induced severe hypoglycemia might explain this inconsistency. Methods Download a PDF of the Research Summary. We randomly assigned patients, on ICU admission, to liberal glucose control

The first two decades of this century saw substantial progress in the control of malaria: deaths from malaria fell by one half, and over the past 10 years, 15 countries have been certified by the World Health Organization as being malaria-free. This success has been achieved by means of the scale-up of effective methods of diagnosis, treatment, chemoprevention, and vector control. Unfortunately, this