This Viewpoint discusses the US Centers for Disease Control and Prevention’s Healthcare Infection Control Practices Advisory Committee and how its termination could affect infection prevention standards in the future.

This JAMA Guide to Statistics and Methods explains tipping point analysis, which assesses how a range of hypothetical patterns in missing outcome data in a randomized clinical trial (RCT) would affect the study’s conclusions, and examines its use in an RCT of treatment for hypertension.

ImportanceAdrenal insufficiency is a syndrome of cortisol deficiency and is categorized as primary, secondary, or glucocorticoid induced. Although primary and secondary adrenal insufficiency are rare, affecting less than 279 per 1 million individuals, glucocorticoid-induced adrenal insufficiency is common.ObservationsPrimary adrenal insufficiency, which involves deficiency of all adrenocortical hormones

ImportanceMortality of American Indian and Alaska Native (AI/AN) persons is known to be high but may be underreported in routine vital statistics.ObjectiveTo estimate age-specific mortality rates and life expectancy for non-Hispanic AI/AN individuals and other racial and ethnic groups, using self-identified race and ethnicity data in a national cohort, circumventing errors due to racial misclassification

In our 2008 paper (Shankar, G. M. et al. Nat. Med. 14, 837–842; 2008), we moved beyond cellular and animal models to isolate pathogenic forms of amyloid-β directly from human brains and apply them to reproduce key features of AD: synaptic dysfunction, loss of dendritic spines, and impaired memory per se. We identified stable dimers of amyloid-β in Alzheimer’s cerebral cortex and their dose-dependent

### What you need to know A 73 year old man is brought to the emergency department following a ground level fall a few hours earlier. His physiological observations are normal, but he cannot remember any events for an hour preceding the fall. Examination reveals an occipital scalp haematoma, but no focal neurological deficit. His Glasgow coma scale (GCS) score is 15. His has a history of atrial fibrillation

Welfare cuts will hit the most deprived areas and the north of England hardest, with long term health and economic harms, write Clare Bambra and colleagues In her Spring Statement in March 2025, the UK Chancellor Rachel Reeves announced several changes to personal independence payments (PIP)—a non-means tested benefit to help with the additional costs of living with a disability or long term health

The NHS must reduce demand for healthcare with spending increases nearing their limits News reports that the NHS is one of the main beneficiaries of the spending review conceal some inconvenient truths. The uplift in budgets of around 3 per cent a year is welcome, but below the long term average of 3.6 per cent a year. It also requires the NHS to deliver implausible productivity improvements of 2 per

We strongly agree with Byworth and colleagues that any reorganisation of the NHS must strengthen public health.1 The NHS has a budget of around £192bn, and there is little performance measurement of how population outcomes are impacted by this investment. Using expert public health input to help reduce health inequalities through the actions of health and care services is an important addition to the

In the age of telemedicine, house calls remain a vital part of primary care—and are in fact on the rise. Indira Subramanian reports House calls might seem to be a relic of the past, but they are thriving in an age where virtual care is a buzzword. Medicaid data show that spending on home and community based services increased from 1% of total Medicaid expenditure on long term services and supports

Decriminalisation needed to protect women from persecution Correspondence to: J Lord j.lord@exeter.ac.uk Abortion is still a criminal offence in England and Wales, with access to abortion permitted under specific circumstances defined in the Abortion Act 1967. One of us (Nicola Packer) was recently acquitted after standing trial in England having been accused of an illegal abortion.1 The high profile

Getting your introduction right can make a real difference, Elisabeth Mahase hears Anna Harvey Bluemel, academic clinical fellow in obstetrics and gynaecology, says, “Understanding names, roles, and levels of training in medicine are important—both to resident doctors, who represent a wide range of experience across all specialties, and to patients. The complexities of medical hierarchies and changes

Importance Tau positron emission tomography (PET) allows in vivo detection of neurofibrillary tangles, a core neuropathologic feature of Alzheimer disease (AD). Objective To provide estimates of the frequency of tau PET positivity and its associated risk of clinical outcomes. Design, Setting, and Participants Longitudinal study using data pooled from 21 cohorts, comprising a convenience sample of 6514

BACKGROUND An interim analysis of progression-free survival in this trial showed that ibrutinib-venetoclax was superior to fludarabine-cyclophosphamide-rituximab (FCR) among patients with chronic lymphocytic leukemia (CLL). Whether ibrutinib-venetoclax is more effective than ibrutinib alone is unclear. METHODS In this phase 3, multicenter, open-label trial, we randomly assigned patients with CLL to

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Managing stocks of pharmaceutical products is a difficult business, for both hospitals and community pharmacies. In the 1950s the Japanese car manufacturers Toyota introduced a just-in-time system, by which only enough cars were manufactured at any time to satisfy actual or expected demand. In doing so they reduced stocks to near zero, thus reducing costs. Since then, just-in-time systems have been

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BackgroundRetifanlimab has activity in programmed death ligand 1-positive advanced squamous cell anal carcinoma (SCAC) that has progressed on platinum chemotherapy. We aimed to prospectively assess the benefit of adding retifanlimab to initial carboplatin–paclitaxel for this disease. MethodsThis global, multicentre, double-blind, randomised, controlled, phase 3 trial was done at 70 centres in 12 countries

BackgroundSurgery and corticosteroid injections are established treatments for carpal tunnel syndrome, but the optimal treatment strategy remains unclear. This study aimed to compare starting treatment with surgery versus starting with a corticosteroid injection. MethodsWe conducted an open-label, randomised controlled trial across 31 hospitals in the Netherlands. Eligible patients, diagnosed with

We appreciate the insights provided by Melk et al. in their Comment1 in Nature Medicine. The authors effectively highlight the importance of structured programs in preparing clinician scientists to bridge the gap between clinical practice and research. However, we would like to emphasize the critical role of medical students in this ecosystem and the need for greater accessibility and support at the

An ambitious Human Exposome Project aims to reveal how our environment shapes our health.

In today’s evolving healthcare landscape, patient engagement has emerged as a cornerstone of delivering high-quality care. By incorporating patient voices throughout the care life cycle, including survivorship, healthcare systems are fostering a more holistic and inclusive approach to treatment and recovery. Modern patient engagement strategies prioritize the active involvement of patients at every

Soda giants have exploited the world’s most popular sport for commercial gain, and FIFA has an opportunity to lead by example by dropping them as sponsors of the 2025 Club World Cup, write Chris van Tulleken and Carlos A Monteiro During the 2022 FIFA World Cup in Qatar, one name dominated the field—and it wasn’t a player. Coca-Cola was ubiquitous,1 appearing on massive billboards, in halftime commercials

The notion that the health service has emerged as a “winner” from the chancellor’s spending review is a bit like congratulating someone who has just won back the face value of a scratch card. It certainly could have been worse, but the NHS is not going to feel materially better off compared to the last decade. Indeed, after adjusting for changes in NHS employer pension contributions and rising national

Assisted dying laws must be transparent, ethically sound, and sensitive to the concerns of patients and practitioners, write Nancy Preston and Suzanne Ost The Terminally Ill Adults (End of Life) Bill is set to continue its report stage on Friday 13 June, before the crucial vote at third reading that will determine its fate.1 If the bill passes third reading it will go to the House of Lords to proceed

Patients don’t always present with cases that fall neatly into “mental” or “physical” boxes, writes James Downs I wanted to feel optimistic when the NHS recently announced that it will be opening specialist mental health centres as an alternative to A&E for people experiencing a mental health crisis.1 Anyone who’s ever sought help in a hospital during a psychiatric crisis—as I have—knows that emergency

Simpson and colleagues call for consistency of access standards across UK medical schools.1 In my role as an occupational health physician at medical and foundation schools, I have observed that a larger percentage of students from the widening participation programme need additional support for factors including impostor syndrome or self esteem issues, …

BACKGROUND Allogeneic peripheral-blood stem-cell transplantation (SCT) from a matched related donor after myeloablative conditioning is the preferred curative treatment for patients with high-risk blood cancers. The combination of a calcineurin inhibitor and an antimetabolite remains standard care for graft-versus-host disease (GVHD) prophylaxis in these patients. Data from two randomized trials have

BACKGROUND International recommendations advise against the use of intravenous rehydration therapy in children with severe acute malnutrition because of the concern about fluid overload, but evidence to support this concern is lacking. Given the high mortality associated with the current recommendations, the adoption of intravenous rehydration strategies might improve outcomes. METHODS We conducted

BACKGROUND In critically ill patients, acceleration of liberation from mechanical ventilation is important in order to reduce the risk of complications and to improve long-term outcomes. Whether the use of proportional-assist ventilation with load-adjustable gain factors (PAV+) results in a shorter time to successful liberation from mechanical ventilation than pressure-support ventilation (PSV) is