Psychological theories cast mindfulness as a form of awareness in which accepting the presence of stressful thoughts and feelings facilitates engaged exploration and identification of adaptive responses. Critics of mindfulness' popularization suggest that lay people misconstrue acceptance as a passive endorsement of experience, undermining engaged problem-solving. To evaluate this criticism, we traced

This systematic review synthesized the literature examining addiction substitution during recovery from substance use or behavioral addictions. A total of 96 studies were included with sample sizes ranging from 6 to 14,885. The most common recovery addictions were opioids (30.21%), followed by cannabis (20.83%), unspecified use (17.71%), nicotine (12.50%), alcohol (12.50%), cocaine (4.17%), and gambling

Moral judgments about interpersonal transgressions are shaped by attributions about the actor’s mental state (intent), responsibility, and harmful consequences. Curiously, most research has investigated these judgments from a third-party perspective, often overlooking perceptions of the individuals directly involved in the transgression. We address this by reviewing research on how victims and transgressors

Antibiotic prescribing can be conceptualised as a social dilemma in which the overuse of antibiotics, to minimise immediate risks to individual patients, results in a sub-optimal outcome for society (antimicrobial resistance) and increased risks to all patients in the long run. Doctors face the challenge of balancing the interests of individual patients against the collective good when prescribing

In this article, we examine the empirical and theoretical support for the idea that experiences of isolation can intensify substance use, even among those in committed close relationships, and can increase the likelihood of negative conflict behaviors, including intimate partner violence (IPV). Cross-sectional, longitudinal, and laboratory-based research suggest that individuals and couples who report

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Drug companies and wealthy countries are facing increased pressure to partner with firms in the global south but are reluctant to relinquish control.

Risk of severe disease drops by factor of almost 20 in people over 60 — but some dispute the benefits of offering a third dose.

A preliminary analysis of viral genomes suggests the COVID-19 pandemic might have multiple animal origins – but the findings still have to be peer reviewed.

Scientists create millions of mutant viruses to find those that excel at ferrying genome-editing tools into muscle tissue.

The chances of heavy rain and high heat within one week are higher now than in the past two millennia, records suggest.

Hear the biggest stories from the world of science | 16 September 2021

Scientists borrow features of the body’s receptor for tetrodotoxin to create a useful synthetic structure.

Southeast Australia experienced intensive and geographically extensive wildfires during the 2019–2020 summer season1,2. The fires released substantial amounts of carbon dioxide into the atmosphere3. However, existing emission estimates based on fire inventories are uncertain4, and vary by up to a factor of four for this event. Here we constrain emission estimates with the help of satellite observations

Adoptive transfer of antigen-specific T cells represents a major advance in cancer immunotherapy, with robust clinical outcomes in some patients1. Both the number of transferred T cells and their differentiation state are critical determinants of effective responses2,3. T cells can be expanded with T cell receptor (TCR)-mediated stimulation and interleukin-2, but this can lead to differentiation into

The Fermi Gamma-ray Space Telescope has revealed a diffuse γ-ray background at energies from 0.1 gigaelectronvolt to 1 teraelectronvolt, which can be separated into emission from our Galaxy and an isotropic, extragalactic component1. Previous efforts to understand the latter have been hampered by the lack of physical models capable of predicting the γ-ray emission produced by the many candidate sources

Transcription-coupled DNA repair removes bulky DNA lesions from the genome1,2 and protects cells against ultraviolet (UV) irradiation3. Transcription-coupled DNA repair begins when RNA polymerase II (Pol II) stalls at a DNA lesion and recruits the Cockayne syndrome protein CSB, the E3 ubiquitin ligase, CRL4CSA and UV-stimulated scaffold protein A (UVSSA)3. Here we provide five high-resolution structures

Hepatitis C virus (HCV) infection is a causal agent of chronic liver disease, cirrhosis and hepatocellular carcinoma in humans, and afflicts more than 70 million people worldwide. The HCV envelope glycoproteins E1 and E2 are responsible for the binding of the virus to the host cell, but the exact entry process remains undetermined1. The majority of broadly neutralizing antibodies block interaction

During the Early Bronze Age, populations of the western Eurasian steppe expanded across an immense area of northern Eurasia. Combined archaeological and genetic evidence supports widespread Early Bronze Age population movements out of the Pontic–Caspian steppe that resulted in gene flow across vast distances, linking populations of Yamnaya pastoralists in Scandinavia with pastoral populations (known

Seven years after the declaration of the first epidemic of Ebola virus disease in Guinea, the country faced a new outbreak—between 14 February and 19 June 2021—near the epicentre of the previous epidemic1,2. Here we use next-generation sequencing to generate complete or near-complete genomes of Zaire ebolavirus from samples obtained from 12 different patients. These genomes form a well-supported phylogenetic

Pancreatic ductal adenocarcinoma (PDAC) is one of the leading causes of cancer deaths worldwide1. Studies in human tissues and in mouse models have suggested that for many cancers, stem cells sustain early mutations driving tumour development2,3. For the pancreas, however, mechanisms underlying cellular renewal and initiation of PDAC remain unresolved. Here, using lineage tracing from the endogenous

Numerous post-transcriptional modifications of transfer RNAs have vital roles in translation. The 2-methylthio-N6-isopentenyladenosine (ms2i6A) modification occurs at position 37 (A37) in transfer RNAs that contain adenine in position 36 of the anticodon, and serves to promote efficient A:U codon–anticodon base-pairing and to prevent unintended base pairing by near cognates, thus enhancing translational

Droughts and climate-change-driven warming are leading to more frequent and intense wildfires1,2,3, arguably contributing to the severe 2019–2020 Australian wildfires4. The environmental and ecological impacts of the fires include loss of habitats and the emission of substantial amounts of atmospheric aerosols5,6,7. Aerosol emissions from wildfires can lead to the atmospheric transport of macronutrients