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Resilience Isn't Found in Trauma, But It May Be Found in Other Life Experiences. Am. J. Psychiatry (IF 17.7) Pub Date : 2023-12-01 Cavan V Bonner,Brent W Roberts
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Adversity and Resilience, Postpartum Depression, Suicide, and Racial/Ethnic Disparities. Am. J. Psychiatry (IF 17.7) Pub Date : 2023-12-01 Ned H Kalin
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The First Large GWAS Meta-Analysis for Postpartum Depression. Am. J. Psychiatry (IF 17.7) Pub Date : 2023-12-01 Jessica Ann May Adams,Prabha Chandra,Divya Mehta
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The STAR*D Data Remain Strong: Reply to Pigott et al. Am. J. Psychiatry (IF 17.7) Pub Date : 2023-12-01 A John Rush,Madhukar Trivedi,Maurizio Fava,Michael Thase,Stephen Wisniewski
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The Consolidated Appropriations Act, 2023: Implications for the Nation's Mental Health Crisis. Am. J. Psychiatry (IF 17.7) Pub Date : 2023-12-01 Joseph H Wu,Eli Y Adashi
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Substance Use Disorders Are Psychiatric Disorders. Am. J. Psychiatry (IF 17.7) Pub Date : 2023-12-01 Alëna A Balasanova
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Substance Use Disorders Are Psychiatric Disorders: Response to Balasanova. Am. J. Psychiatry (IF 17.7) Pub Date : 2023-12-01 Ned H Kalin
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A Mental Health Crisis and Call to Action: Increasing Trends in Suicide Among Black Women in the United States. Am. J. Psychiatry (IF 17.7) Pub Date : 2023-12-01 Ruth S Shim,Carolyn I Rodriguez
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Perinatal Mental Health: Advances and Opportunities. Am. J. Psychiatry (IF 17.7) Pub Date : 2023-12-01 Zachary N Stowe
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Recurrent Anti-NMDA Receptor Encephalitis After Mycoplasma Pneumonia Infection. Am. J. Psychiatry (IF 17.7) Pub Date : 2023-12-01 Katherine S Dickson,Donald L Rosenstein,Nathaniel A Sowa
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Learning From Racial Disparities in COVID-19-Related Stress. Am. J. Psychiatry (IF 17.7) Pub Date : 2023-12-01 Rachel Yehuda,Sidney H Hankerson
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Trends in Suicide Among Black Women in the United States, 1999-2020. Am. J. Psychiatry (IF 17.7) Pub Date : 2023-12-01 Victoria A Joseph,Gonzalo Martínez-Alés,Mark Olfson,Jeffrey Shaman,Madelyn S Gould,Catherine Gimbrone,Katherine M Keyes
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Trends in Prevalence of Cannabis Use Disorder Among U.S. Veterans With and Without Psychiatric Disorders Between 2005 and 2019 Am. J. Psychiatry (IF 17.7) Pub Date : 2023-11-29 Ofir Livne, Carol A. Malte, Mark Olfson, Melanie M. Wall, Katherine M. Keyes, Charles Maynard, Jaimie L. Gradus, Andrew J. Saxon, Silvia S. Martins, Salomeh Keyhani, Yoanna McDowell, David S. Fink, Zachary L. Mannes, Sarah Gutkind, Deborah S. Hasin
Objective: Cannabis use disorder diagnoses are increasing among U.S. adults and are more prevalent among people with comorbid psychiatric disorders. Recent changes in cannabis laws, increasing cannabis availability, and higher-potency cannabis may have placed people with cannabis use and psychiatric disorders at disproportionately increasing risk for cannabis use disorder. The authors used Veterans
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The Long-Term Relationship Between Cannabis and Heroin Use: An 18- to 20-year Follow-Up of the Australian Treatment Outcome Study (ATOS) Am. J. Psychiatry (IF 17.7) Pub Date : 2023-11-29 Jack Wilson, Katherine L. Mills, Matthew Sunderland, Tom P. Freeman, Maree Teesson, Paul S. Haber, Christina Marel
Objective: Cannabis use is common among individuals with opioid use disorder, but it remains unclear whether cannabis use is associated with an increase or a reduction in illicit opioid use. To overcome limitations identified in previous longitudinal studies with limited follow-ups, the authors examined a within-person reciprocal relationship between cannabis and heroin use at several follow-ups over
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Converging Evidence for Frontopolar Cortex as a Target for Neuromodulation in Addiction Treatment Am. J. Psychiatry (IF 17.7) Pub Date : 2023-11-29 Ghazaleh Soleimani, Juho Joutsa, Khaled Moussawi, Shan H. Siddiqi, Rayus Kuplicki, Marom Bikson, Martin P. Paulus, Michael D. Fox, Colleen A. Hanlon, Hamed Ekhtiari
Noninvasive brain stimulation technologies such as transcranial electrical and magnetic stimulation (tES and TMS) are emerging neuromodulation therapies that are being used to target the neural substrates of substance use disorders. By the end of 2022, 205 trials of tES or TMS in the treatment of substance use disorders had been published, with heterogeneous results, and there is still no consensus
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Adult Mental Health, Substance Use Disorders, and Functional Outcomes of Children Resilient to Early Adversity Am. J. Psychiatry (IF 17.7) Pub Date : 2023-11-09 William E. Copeland, Julia Halvorson-Phelan, Ellen McGinnis, Lilly Shanahan
Objective: Some children are unaffected by mental illness despite exposure to childhood adversity. These children are typically considered resilient. The objective of this study was to follow up such resilient children in adulthood to characterize mental health status, substance use, and functional outcomes. Methods: The analysis was based on the prospective, representative Great Smoky Mountains Study
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Racial and Ethnic Disparities in COVID-19-Related Stressor Exposure and Adverse Mental Health Outcomes Among Health Care Workers. Am. J. Psychiatry (IF 17.7) Pub Date : 2023-11-09 Aaron Samuel Breslow,Sherry Simkovic,Peter J Franz,Elizabeth Cavic,Qi Liu,Natalie Ramsey,Jonathan E Alpert,Benjamin Le Cook,Vilma Gabbay
OBJECTIVE Racial and ethnic disparities in exposure to COVID-19-related stressors, pandemic-related distress, and adverse mental health outcomes were assessed among health care workers in the Bronx, New York, during the first wave of the pandemic. METHODS The authors analyzed survey data from 992 health care workers using adjusted logistic regression models to assess differential prevalence of outcomes
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Recapitulation of Perturbed Striatal Gene Expression Dynamics of Donor’s Brains With Ventral Forebrain Organoids Derived From the Same Individuals With Schizophrenia Am. J. Psychiatry (IF 17.7) Pub Date : 2023-11-02 Tomoyo Sawada, André R. Barbosa, Bruno Araujo, Alejandra E. McCord, Laura D’Ignazio, Kynon J.M. Benjamin, Bonna Sheehan, Michael Zabolocki, Arthur Feltrin, Ria Arora, Anna C. Brandtjen, Joel E. Kleinman, Thomas M. Hyde, Cedric Bardy, Daniel R. Weinberger, Apuã C.M. Paquola, Jennifer A. Erwin
Objective: Schizophrenia is a brain disorder that originates during neurodevelopment and has complex genetic and environmental etiologies. Despite decades of clinical evidence of altered striatal function in affected patients, studies examining its cellular and molecular mechanisms in humans are limited. To explore neurodevelopmental alterations in the striatum associated with schizophrenia, the authors
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An Avenue for Optimization of Theta Burst Stimulation Protocols? Comments on the FOUR-D Randomized Noninferiority Clinical Trial. Am. J. Psychiatry (IF 17.7) Pub Date : 2023-11-02 Jean-Marie V Batail,Michael T Feyder,Brandon S Bentzley,Nolan R Williams
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Structural Racism and Risk of Schizophrenia. Am. J. Psychiatry (IF 17.7) Pub Date : 2023-11-01 Els van der Ven,Ezra Susser
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Predicting Conversion to Psychosis Using Machine Learning: Are We There Yet? Am. J. Psychiatry (IF 17.7) Pub Date : 2023-11-01 Tyrone D Cannon
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Points that Need Attention in Early Auditory Information Processing Research in Schizophrenia: Response to Lin and Hsieh. Am. J. Psychiatry (IF 17.7) Pub Date : 2023-11-01 Yash Joshi,Neal Swerdlow,Gregory Light
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Another Step Toward the Prediction of Antipsychotic Treatment Response Using Functional Connectivity. Am. J. Psychiatry (IF 17.7) Pub Date : 2023-11-01 Donald C Goff,Joshua Roffman,Daphne J Holt
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Dissecting the Genetic Relationship Between Schizophrenia and Cardiovascular Disease. Am. J. Psychiatry (IF 17.7) Pub Date : 2023-11-01 Rona J Strawbridge,Nicholas Graham
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Rethinking the First Episode of Schizophrenia: Identifying Convergent Mechanisms During Development and Moving Toward Prediction. Am. J. Psychiatry (IF 17.7) Pub Date : 2023-11-01 Jennifer K Forsyth,Carrie E Bearden
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Meta-Analyses of Genome-Wide Association Studies for Postpartum Depression Am. J. Psychiatry (IF 17.7) Pub Date : 2023-10-18 Jerry Guintivano, Enda M. Byrne, Jacqueline Kiewa, Shuyang Yao, Anna E. Bauer, Karolina A. Aberg, Mark J. Adams, Archie Campbell, Megan L. Campbell, Karmel W. Choi, Elizabeth C. Corfield, Alexandra Havdahl, Donald Hucks, Nastassja Koen, Yi Lu, Merete L. Mægbæk, Jimmy Mullaert, Roseann E. Peterson, Laura M. Raffield, Hannah M. Sallis, Julia M. Sealock, Alicia Walker, Hunna J. Watson, Ying Xiong, Jessica
Objective: Postpartum depression (PPD) is a common subtype of major depressive disorder (MDD) that is more heritable, yet is understudied in psychiatric genetics. The authors conducted meta-analyses of genome-wide association studies (GWASs) to investigate the genetic architecture of PPD. Method: Meta-analyses were conducted on 18 cohorts of European ancestry (17,339 PPD cases and 53,426 controls)
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Real-World Evidence on Clinical Outcomes of Commonly Used Antidepressants in Older Adults Initiating Antidepressants for Depression: A Nationwide Cohort Study in Denmark Am. J. Psychiatry (IF 17.7) Pub Date : 2023-10-18 Kazi Ishtiak-Ahmed, Katherine L. Musliner, Kaj Sparle Christensen, Erik Lykke Mortensen, Andrew A. Nierenberg, Christiane Gasse
Objective: The authors investigated the clinical outcomes of commonly used antidepressants among older adults who initiated first-time antidepressants for depression by analyzing the 1-year risk of selected clinically relevant outcomes. Methods: This cohort study used nationwide Danish registry data and included all older adults who redeemed a first-time (since 1995) antidepressant prescription with
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Are We There Yet? Predicting Conversion to Psychosis Using Machine Learning. Am. J. Psychiatry (IF 17.7) Pub Date : 2023-10-04 Jason Smucny,Ian Davidson,Cameron S Carter
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Inequalities in the Incidence of Psychotic Disorders Among Racial and Ethnic Groups Am. J. Psychiatry (IF 17.7) Pub Date : 2023-10-04 Winston Chung, Sheng-Fang Jiang, Michael P. Milham, Kathleen R. Merikangas, Diana Paksarian
Objective: The authors examined recent trends in incidence of psychotic disorders, demographic characteristics, and comorbid psychiatric and medical conditions among six racial/ethnic groups. Method: A retrospective cohort study design was used to examine the incidence of psychotic disorders across race/ethnicity groups and comorbid psychiatric and medical conditions among members of Kaiser Permanente
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Effects of Bundling Medication for Opioid Use Disorder With an mHealth Intervention Targeting Addiction: A Randomized Clinical Trial Am. J. Psychiatry (IF 17.7) Pub Date : 2023-10-04 David H. Gustafson, Sr., Gina Landucci, Olivia J. Vjorn, Rachel E. Gicquelais, Simon B. Goldberg, Darcie C. Johnston, John J. Curtin, Genie L. Bailey, Dhavan V. Shah, Klaren Pe-Romashko, David H. Gustafson, Jr.
Objective: Medication for opioid use disorder (MOUD) improves treatment retention and reduces illicit opioid use. A-CHESS is an evidence-based smartphone intervention shown to improve addiction-related behaviors. The authors tested the efficacy of MOUD alone versus MOUD plus A-CHESS to determine whether the combination further improved outcomes. Methods: In an unblinded parallel-group randomized controlled
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GWAS Meta-Analysis of Suicide Attempt: Identification of 12 Genome-Wide Significant Loci and Implication of Genetic Risks for Specific Health Factors. Am. J. Psychiatry (IF 17.7) Pub Date : 2023-10-01 Anna R Docherty,Niamh Mullins,Allison E Ashley-Koch,Xuejun Qin,Jonathan R I Coleman,Andrey Shabalin,JooEun Kang,Balasz Murnyak,Frank Wendt,Mark Adams,Adrian I Campos,Emily DiBlasi,Janice M Fullerton,Henry R Kranzler,Amanda V Bakian,Eric T Monson,Miguel E Rentería,Consuelo Walss-Bass,Ole A Andreassen,Chittaranjan Behera,Cynthia M Bulik,Howard J Edenberg,Ronald C Kessler,J John Mann,John I Nurnberger
OBJECTIVE Suicidal behavior is heritable and is a major cause of death worldwide. Two large-scale genome-wide association studies (GWASs) recently discovered and cross-validated genome-wide significant (GWS) loci for suicide attempt (SA). The present study leveraged the genetic cohorts from both studies to conduct the largest GWAS meta-analysis of SA to date. Multi-ancestry and admixture-specific meta-analyses
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Stress, Heritability, and Genetic Factors Influencing Depression, PTSD, and Suicidal Behavior. Am. J. Psychiatry (IF 17.7) Pub Date : 2023-10-01 Ned H Kalin
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Maternal Perinatal Stress Associated With Offspring Negative Emotionality, But the Underlying Mechanisms Remain Elusive. Am. J. Psychiatry (IF 17.7) Pub Date : 2023-10-01 Alexander J Shackman,Dylan G Gee
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New Insights Into Suicidal Behavior From Large Multi-Ancestry Genetic Meta-Analysis. Am. J. Psychiatry (IF 17.7) Pub Date : 2023-10-01 Elisabeth B Binder
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Characterizing the Shared Genetic Underpinnings of Schizophrenia and Cardiovascular Disease Risk Factors Am. J. Psychiatry (IF 17.7) Pub Date : 2023-09-27 Linn Rødevand, Zillur Rahman, Guy F.L. Hindley, Olav B. Smeland, Oleksandr Frei, Tahir Filiz Tekin, Gleda Kutrolli, Shahram Bahrami, Eva Z. Hoseth, Alexey Shadrin, Aihua Lin, Srdjan Djurovic, Anders M. Dale, Nils Eiel Steen, Ole A. Andreassen
Objective: Schizophrenia is associated with increased risk of cardiovascular disease (CVD), although there is variation in risk among individuals. There are indications of shared genetic etiology between schizophrenia and CVD, but the nature of the overlap remains unclear. The aim of this study was to fill this gap in knowledge. Methods: Overlapping genetic architectures between schizophrenia and CVD
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Long-Term Use of Benzodiazepines and Benzodiazepine-Related Drugs: A Register-Based Danish Cohort Study on Determinants and Risk of Dose Escalation Am. J. Psychiatry (IF 17.7) Pub Date : 2023-09-20 Thomas Wolff Rosenqvist, Marie Kim Wium-Andersen, Ida Kim Wium-Andersen, Martin Balslev Jørgensen, Merete Osler
Objective: The authors investigated the frequency and determinants of long-term use and risk of dose escalation of benzodiazepines and benzodiazepine-related drugs (benzodiazepine receptor agonists, or BZRAs). Methods: All adults ages 20–80 years living in Denmark on January 1, 2000 (N=4,297,045) were followed for redeemed prescriptions of BZRAs in the Danish National Prescription Registry from January
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Recent Secular Trends of Body Mass Index in Individuals With Bipolar Disorders and in the General Population Am. J. Psychiatry (IF 17.7) Pub Date : 2023-09-20 Hemen Najar, Erik Joas, Viktor Jonsson, Erik Pålsson, Mikael Landén
Objective: The aims of this study were to investigate secular trends and distribution of body mass index (BMI) among individuals with bipolar disorders and the general population between 2008 and 2019. Methods: Data were from the Swedish National Quality Register for Bipolar Disorder, where 24,423 adults with bipolar disorders were identified, and from the national Swedish Living Conditions Surveys
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Maternal Perinatal Stress Trajectories and Negative Affect and Amygdala Development in Offspring Am. J. Psychiatry (IF 17.7) Pub Date : 2023-09-06 Mollie C. Marr, Alice M. Graham, Eric Feczko, Saara Nolvi, Elina Thomas, Darrick Sturgeon, Emma Schifsky, Jerod M. Rasmussen, John H. Gilmore, Martin Styner, Sonja Entringer, Pathik D. Wadhwa, Riikka Korja, Hasse Karlsson, Linnea Karlsson, Claudia Buss, Damien A. Fair
Objective: Maternal psychological stress during pregnancy is a common risk factor for psychiatric disorders in offspring, but little is known about how heterogeneity of stress trajectories during pregnancy affect brain systems and behavioral phenotypes in infancy. This study was designed to address this gap in knowledge. Methods: Maternal anxiety, stress, and depression were assessed at multiple time
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Subcortical Anatomy in Neurogenetic Disorders: New Findings and Future Questions. Am. J. Psychiatry (IF 17.7) Pub Date : 2023-09-01 Konrad Wagstyl,Armin Raznahan
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Seeking New Solutions Addressing Structural Racism, Childhood Trauma, Suicidal Behaviors Across Sexual Orientations, and Postpartum Depression. Am. J. Psychiatry (IF 17.7) Pub Date : 2023-09-01 Ned H Kalin
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Through a Developmental Lens: Emerging Insights to Understand and Treat Pediatric PTSD. Am. J. Psychiatry (IF 17.7) Pub Date : 2023-09-01 Justin D Russell,Sara A Heyn,Ryan J Herringa
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Sexual Orientation and Suicidal Behavior: Is It Getting Better? Am. J. Psychiatry (IF 17.7) Pub Date : 2023-09-01 Gregory E Simon
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Zuranolone Treatment for Depression: Steady Progress in Mechanism-Focused Therapeutics? Am. J. Psychiatry (IF 17.7) Pub Date : 2023-09-01 Daniel S Pine
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Genetic Contribution to the Heterogeneity of Major Depressive Disorder: Evidence From a Sibling-Based Design Using Swedish National Registers Am. J. Psychiatry (IF 17.7) Pub Date : 2023-08-30 Thuy-Dung Nguyen, Kaarina Kowalec, Joëlle Pasman, Henrik Larsson, Paul Lichtenstein, Christina Dalman, Patrick F. Sullivan, Ralf Kuja-Halkola, Yi Lu
Objective: Major depressive disorder (MDD) is highly heterogeneous. Standard typology partly captures the disorder’s symptomatic heterogeneity, although whether it adequately captures etiological heterogeneity remains elusive. The aim of this study was to investigate the genetic characterization of MDD heterogeneity. Methods: Using Swedish patient register data on 1.5 million individuals, the authors
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A Functional Connectome-Based Neural Signature for Individualized Prediction of Antipsychotic Response in First-Episode Psychosis Am. J. Psychiatry (IF 17.7) Pub Date : 2023-08-30 Hengyi Cao, Todd Lencz, Juan A. Gallego, Jose M. Rubio, Majnu John, Anita D. Barber, Michael L. Birnbaum, Delbert G. Robinson, Anil K. Malhotra
Objective: Identification of robust biomarkers that predict individualized response to antipsychotic treatment at the early stage of psychotic disorders remains a challenge in precision psychiatry. The aim of this study was to investigate whether any functional connectome-based neural traits could serve as such a biomarker. Methods: In a discovery sample, 49 patients with first-episode psychosis received
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Networks of Neurodevelopmental Traits, Socioenvironmental Factors, Emotional Dysregulation in Childhood, and Depressive Symptoms Across Development in Two U.K. Cohorts Am. J. Psychiatry (IF 17.7) Pub Date : 2023-08-16 Luis C. Farhat, Rachel Blakey, George Davey Smith, André Fujita, Elizabeth Shephard, Evie Stergiakouli, Thalia C. Eley, Anita Thapar, Guilherme V. Polanczyk
Objective: Previous population-based studies have identified associations between childhood neurodevelopmental traits and depression in childhood, adolescence, and young adulthood. However, neurodevelopmental traits are highly correlated with each other, which could confound associations when traits are examined in isolation. The authors sought to identify unique associations between multiple neurodevelopmental
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Alcohol Consumption and Alcohol Use Disorder: Exposing an Increasingly Shared Genetic Architecture. Am. J. Psychiatry (IF 17.7) Pub Date : 2023-08-01 Julie D White,Laura J Bierut
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Rebecca W. Brendel, M.D., J.D., 149th President, 2022-2023. Am. J. Psychiatry (IF 17.7) Pub Date : 2023-08-01 Charles Dike
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Treatment of Opioid Use Disorder in the General Hospital. Am. J. Psychiatry (IF 17.7) Pub Date : 2023-08-01 Margo C Funk,Sara Nash,Allison Smith,Kelly Barth,Joji Suzuki,James K Rustad,Stefania Buonocore,Abhisek C Khandai,Michael A Smith,Shawn Jin,Karen Drexler,John A Renner
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Science Into Policy for the Benefit of Children: The Bucharest Early Intervention Project. Am. J. Psychiatry (IF 17.7) Pub Date : 2023-08-01 Helen Minnis
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Early-life Adversity and Genetics Associated With the Risk to Develop Psychiatric Illnesses. Am. J. Psychiatry (IF 17.7) Pub Date : 2023-08-01 Ned H Kalin
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The Devastating Clinical Consequences of Child Abuse and Neglect: Increased Disease Vulnerability and Poor Treatment Response in Mood Disorders Am. J. Psychiatry (IF 17.7) Pub Date : 2023-08-01 Elizabeth T.C. Lippard, Charles B. Nemeroff
A large body of evidence has demonstrated that exposure to childhood maltreatment at any stage of development can have long-lasting consequences. It is associated with a marked increase in risk for psychiatric and medical disorders. This review summarizes the literature investigating the effects of childhood maltreatment on disease vulnerability for mood disorders, specifically summarizing cross-sectional
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Translating Developmental Neuroscience to Understand Risk for Psychiatric Disorders Am. J. Psychiatry (IF 17.7) Pub Date : 2023-08-01 Heidi C. Meyer, Francis S. Lee
The transition from childhood to adulthood represents the developmental time frame in which the majority of psychiatric disorders emerge. Recent efforts to identify risk factors mediating the susceptibility to psychopathology have led to a heightened focus on both typical and atypical trajectories of neural circuit maturation. Mounting evidence has highlighted the immense neural plasticity apparent
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Overview of Alcohol Use Disorder Am. J. Psychiatry (IF 17.7) Pub Date : 2023-08-01 Henry R. Kranzler
Alcohol is regularly consumed throughout most of the world, including by nearly half the U.S. population age 12 or older. Heavy drinking, which is also common, contributes to multiple adverse medical, psychiatric, and social outcomes and more than 140,000 deaths annually in the United States. It is the major risk factor for alcohol use disorder (AUD), whose current U.S. prevalence is 11%. However,
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Zuranolone for the Treatment of Postpartum Depression Am. J. Psychiatry (IF 17.7) Pub Date : 2023-07-26 Kristina M. Deligiannidis, Samantha Meltzer-Brody, Bassem Maximos, E. Quinn Peeper, Marlene Freeman, Robert Lasser, Amy Bullock, Mona Kotecha, Sigui Li, Fiona Forrestal, Nilanjana Rana, Manny Garcia, Bridgette Leclair, James Doherty
Objective: Postpartum depression (PPD) is a common perinatal complication with adverse maternal and infant outcomes. This study investigated the efficacy and safety of zuranolone, a positive allosteric modulator of synaptic and extrasynaptic GABAA receptors and neuroactive steroid, as an oral, once-daily, 14-day treatment course for patients with severe PPD. Methods: In this double-blind phase 3 trial
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Single-Nucleus Transcriptome Profiling of Dorsolateral Prefrontal Cortex: Mechanistic Roles for Neuronal Gene Expression, Including the 17q21.31 Locus, in PTSD Stress Response Am. J. Psychiatry (IF 17.7) Pub Date : 2023-07-26 Chris Chatzinakos, Cameron D. Pernia, Filomene G. Morrison, Artemis Iatrou, Kenneth M. McCullough, Heike Schuler, Clara Snijders, Thomas Bajaj, Christopher P. DiPietro, Marina Soliva Estruch, Nils C. Gassen, Constantin Anastasopoulos, Rahul A. Bharadwaj, Benjamin C. Bowlby, Jakob Hartmann, Adam X. Maihofer, Caroline M. Nievergelt, Nicholas M. Ressler, Erika J. Wolf, Traumatic Stress Brain Research
Objective: Multidisciplinary studies of posttraumatic stress disorder (PTSD) and major depressive disorder (MDD) implicate the dorsolateral prefrontal cortex (DLPFC) in disease risk and pathophysiology. Postmortem brain studies have relied on bulk-tissue RNA sequencing (RNA-seq), but single-cell RNA-seq is needed to dissect cell-type-specific mechanisms. The authors conducted the first single-nucleus
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Subcortical Brain Alterations in Carriers of Genomic Copy Number Variants Am. J. Psychiatry (IF 17.7) Pub Date : 2023-07-12 Kuldeep Kumar, Claudia Modenato, Clara Moreau, Christopher R.K. Ching, Annabelle Harvey, Sandra Martin-Brevet, Guillaume Huguet, Martineau Jean-Louis, Elise Douard, Charles-Olivier Martin, Nadine Younis, Petra Tamer, Anne M. Maillard, Borja Rodriguez-Herreros, Aurélie Pain, 16p11.2 European Consortium, Simons Searchlight Consortium, Leila Kushan, Dmitry Isaev, Kathryn Alpert, Anjani Ragothaman, Jessica
Objective: Copy number variants (CNVs) are well-known genetic pleiotropic risk factors for multiple neurodevelopmental and psychiatric disorders (NPDs), including autism (ASD) and schizophrenia. Little is known about how different CNVs conferring risk for the same condition may affect subcortical brain structures and how these alterations relate to the level of disease risk conferred by CNVs. To fill
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Association of Cortico-Striatal Engagement During Cue Reactivity, Reappraisal, and Savoring of Drug and Non-Drug Stimuli With Craving in Heroin Addiction Am. J. Psychiatry (IF 17.7) Pub Date : 2023-07-12 Yuefeng Huang, Ahmet O. Ceceli, Greg Kronberg, Sarah King, Pias Malaker, Muhammad A. Parvaz, Nelly Alia-Klein, Eric L. Garland, Rita Z. Goldstein
Objective: The authors investigated cortico-striatal reactivity to drug cues (as compared with neutral and food cues), drug cue reappraisal, food cue savoring, and their correlations with heroin craving in individuals with heroin use disorder compared with healthy control subjects. Methods: Cross-sectional changes in functional MRI blood-oxygen-level-dependent signal during a novel cue reactivity task
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Cerebrovascular Disease and Neuropsychiatric Disorders: Translating Findings From the MRI Scanner to the Clinic. Am. J. Psychiatry (IF 17.7) Pub Date : 2023-07-01 David C Steffens
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From Postmortem Molecular Studies to Social Determinants of Health Relevant to Racial and Ethnic Disparities. Am. J. Psychiatry (IF 17.7) Pub Date : 2023-07-01 Ned H Kalin