SARS-CoV-2 has evolved variants with substitutions in the spike receptor-binding domain (RBD) that impact its affinity for ACE2 receptor and recognition by antibodies. These substitutions could also shape future evolution by modulating the effects of mutations at other sites—a phenomenon called epistasis. To investigate this possibility, we performed deep mutational scans to measure the effects on

The once slow spreading virus may have found a new niche in tightly connected sexual networks.

Global satellite data quantify changes in sediment flux in 414 rivers.

The origins of the world's chief writing system come to life in an illuminating historiography.

Tourism fails to compensate for lost timber jobs in protected forests, leading some to theft.

Ensure open markets for clean technologies and products.

Nitriles functionalize amines and ammonia under catalytic hydrogenation conditions.

Early-career researchers increasingly avoid low-paying, insecure postdoc positions, a Science investigation finds.

Swedish court gives Paolo Macchiarini suspended sentence for death of windpipe transplant patient.

Applied physicist would bring wealth of policy experience as successor to Eric Lander.

A long-lasting injectable drug was tested in seven African countries. But it's unclear when they'll have access to it.

The nutritional value of marine algae will decrease in a warmer world.

Shallow and deep human subsurface activities contribute to the total subsidence.

Two new studies find little evidence of aging in some turtle species.

A new discovery challenges the prevailing view of the boundaries of bacterial cell size.

Trials suggest small electric currents aid fluency, but how long the benefits last is unclear.

Human activities have caused global temperatures to increase by 1.25°C, and the current emissions trajectory suggests that we will exceed 1.5°C in less than 10 years. Though the growth rate of global carbon dioxide emissions has slowed and many countries have strengthened their emissions targets, current midcentury net zero goals are insufficient to limit global warming to 1.5°C above preindustrial

The in vivo pathogenicity, transmissibility, and fitness of the SARS-CoV-2 Omicron (B.1.1.529) variant are unclear. We compared these virological attributes of this new variant of concern with those of the Delta (B.1.617.2) variant in a Syrian hamster model of COVID-19. Omicron-infected hamsters lost significantly less body weight and exhibited reduced clinical scores, respiratory tract viral burdens

Cells of most bacterial species are around 2 micrometers in length, with some of the largest specimens reaching 750 micrometers. Using fluorescence, x-ray, and electron microscopy in conjunction with genome sequencing, we characterized Candidatus ( Ca. ) Thiomargarita magnifica, a bacterium that has an average cell length greater than 9000 micrometers and is visible to the naked eye. These cells grow

Changing the course of Earth’s climate is increasingly urgent, but there is also a concurrent need for proactive stewardship of the adaptive capacity of the rapidly changing biosphere. Adaptation ultimately underpins the resilience of Earth’s complex systems; species, communities, and ecosystems shift and evolve over time. Yet oncoming changes will seriously challenge current natural resource management

Global-scale surveys of plankton communities using “omics” techniques have revolutionized our understanding of the ocean. Lipidomics has demonstrated the potential to add further essential insights on ocean ecosystem function but has yet to be applied on a global scale. We analyzed 930 lipid samples across the global ocean using a uniform high-resolution accurate-mass mass spectrometry analytical workflow

David et al . claim that vestibular shape does not reflect function and that we did not use phylogenetic inference methods in our primary analyses. We show that their claims are countered by comparative and direct experimental evidence from across Vertebrata and that their models are empirically unverified. We did use phylogenetic methods to test our hypotheses. Moreover, their phylogenetic correction

A clean energy transition will create jobs, promote energy independence, improve public health, and, ultimately, mitigate climate change. But getting to this new future will require more than just phasing out fossil fuels. The production of a wide range of energy-relevant materials—lithium, cobalt, and nickel for batteries; rare earth elements for wind turbines and electric motors; silicon for solar

Oxidative DNA damage is recognized by 8-oxoguanine (8-oxoG) DNA glycosylase 1 (OGG1), which excises 8-oxoG, leaving a substrate for apurinic endonuclease 1 (APE1) and initiating repair. Here, we describe a small molecule (TH10785) that interacts with the phenylalanine-319 and glycine-42 amino acids of OGG1, increases the enzyme activity 10-fold, and generates a previously undescribed β,δ-lyase enzymatic

Hanson et al . (Research Articles, 7 May 2021, p. 601) claim that the shape of the vestibular apparatus reflects the evolution of reptilian locomotion. Using biomechanics, we demonstrate that semicircular canal shape is a dubious predictor of semicircular duct function. Additionally, we show that the inference methods used by Hanson et al . largely overestimate relationships between semicircular canal

Without rapid changes to agriculture and food systems, the goals of the 2015 Paris Agreement on climate change will not be met. Food systems are one of the most important contributors to greenhouse gas (GHG) emissions, but they also need to be adapted to cope with climate change impacts. Although many options exist to reduce GHG emissions in the food system, efforts to develop implementable transformation

Is senescence inevitable and universal for all living organisms, as evolutionary theories predict? Although evidence generally supports this hypothesis, it has been proposed that certain species, such as turtles and tortoises, may exhibit slow or even negligible senescence—i.e., avoiding the increasing risk of death from gradual deterioration with age. In an extensive comparative study of turtles and

The performance of perovskite solar cells with inverted polarity ( p-i-n ) is still limited by recombination at their electron extraction interface, which also lowers the power conversion efficiency (PCE) of p-i-n perovskite-silicon tandem solar cells. A ~1 nm thick MgF x interlayer at the perovskite/C 60 interface through thermal evaporation favorably adjusts the surface energy of the perovskite layer

The human cerebral cortex houses 1,000 times more neurons than the cerebral cortex of a mouse, but the possible differences in synaptic circuits between these species are still poorly understood. We used 3-dimensional electron microscopy of mouse, macaque and human cortical samples to study their cell type composition and synaptic circuit architecture. The 2.5-fold increase in interneurons in humans

Comparative studies of mortality in the wild are necessary to understand the evolution of aging; yet, ectothermic tetrapods are underrepresented in this comparative landscape, despite their suitability for testing evolutionary hypotheses. We present a study of aging rates and longevity across wild tetrapod ectotherms, using data from 107 populations (77 species) of nonavian reptiles and amphibians

Although many governments, financial institutions, and corporations are embracing nature-based solutions as part of their sustainability and net-zero carbon strategies, some nations, Indigenous peoples, local community groups, and grassroots organizations have rejected this term. This pushback is fueled by (i) critical uncertainties about when, where, how, and for whom nature-based solutions are effective

Rivers support indispensable ecological functions and human health and infrastructure. Yet limited river sampling hinders our understanding of consequential changes to river systems. Satellite-based estimates of suspended sediment concentration and flux for 414 major rivers reveal widespread global change that is directly attributable to human activity in the past half-century. Sediment trapping by

Changes in woody biomass over centuries to millennia are poorly known, leaving unclear the magnitude of terrestrial carbon fluxes before industrial-era disturbance. Here, we statistically reconstructed changes in woody biomass across the upper Midwestern region of the United States over the past 10,000 years using a Bayesian model calibrated to preindustrial forest biomass estimates and fossil pollen

Efficient and general methods for the synthesis of amines remain in high demand in the chemical industry. Among the many known processes, catalytic hydrogenation is a cost-effective and industrially proven reaction and currently used to produce a wide array of such compounds. We report a homogeneous nickel catalyst for hydrogenative cross coupling of a range of aromatic, heteroaromatic, and aliphatic

Tumor necrosis factor (TNF) is a critical host resistance factor against tuberculosis. However, excess TNF produces susceptibility by increasing mitochondrial reactive oxygen species (mROS), which initiate a signaling cascade to cause pathogenic necrosis of mycobacterium-infected macrophages. In zebrafish, we identified the mechanism of TNF-induced mROS in tuberculosis. Excess TNF in mycobacterium-infected

Leading literary writers explore what it means to live on a changing planet.

Inexpensive "liquid mirrors" could be used in giant telescopes on the Moon.

Use of D NA markers in research that are used in law enforcement risks undermining public trust and participation.

Concern grows that virus will get footholds in species outside Africa.

Increasing potential for fast, cheap genomes may break open biology's bottleneck and broaden clinical uses.

The anthropogenic share of marine oil discharge is much larger than previously thought.

A new biography juxtaposes the physicist's life story with the search for the Higgs boson.

Record-shattering events spur climate attribution advances.

Graves in Kyrgyzstan hold early victims of plague that swept medieval Europe.

Ten years ago, physicists found what they predicted. Little new has followed.

Volatile chemical elements are thought to have been delivered to Solar System terrestrial planets late in their formation, by accretion of chondritic meteorites. Mars can provide information on inner Solar System volatile delivery during the earliest planet formation stages. We measured krypton isotopes in the Martian meteorite Chassigny, representative of the planet’s interior. We find chondritic

Effective tissue repair after myocardial infarction entails a vigorous angiogenic response, guided by incompletely defined immune cell–endothelial cell interactions. We identify the monocyte- and macrophage-derived cytokine METRNL (meteorin-like) as a driver of postinfarction angiogenesis and high-affinity ligand for the stem cell factor receptor KIT (KIT receptor tyrosine kinase). METRNL mediated

Advances in additive manufacturing techniques have enabled the creation of stimuli-responsive materials with designed three-dimensional (3D) architectures. Unlike biological systems in which functions such as sensing, actuation, and control are closely integrated, few architected materials have comparable system complexity. We report a design and manufacturing route to create a class of robotic metamaterials

Ultracold atoms confined to periodic potentials have proven to be a powerful tool for quantum simulation of complex many-body systems. We confine fermions to one dimension to realize the Tomonaga-Luttinger liquid model, which describes the highly collective nature of their low-energy excitations. We use Bragg spectroscopy to directly excite either the spin or charge waves for various strengths of repulsive

Ocean oil slicks can be attributed to natural seepages or to anthropogenic discharges. To date, the global picture of their distribution and relative natural and anthropogenic contributions remains unclear. Here, by analyzing 563,705 Sentinel-1 images from 2014–2019, we provide the first global map of oil slicks and a detailed inventory of static-and-persistent sources (natural seeps, platforms, and

The emergence of new therapeutic modalities requires complementary tools for their efficient syntheses. Availability of methodologies for site-selective modification of biomolecules remains a long-standing challenge, given the inherent complexity and the presence of repeating residues that bear functional groups with similar reactivity profiles. We describe a bioconjugation strategy for modification