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A Three-Dimensional sp2 Carbon-Conjugated Covalent Organic Framework J. Am. Chem. Soc. (IF 15.419) Pub Date : 2021-09-17 Shitao Wang, Xiang-Xiang Li, Ling Da, Yaqin Wang, Zhehao Xiang, Wei Wang, Yue-Biao Zhang, Dapeng Cao
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Nickel(II)-Catalyzed Addition of Aryl and Heteroaryl Boroxines to the Sulfinylamine Reagent TrNSO: The Catalytic Synthesis of Sulfinamides, Sulfonimidamides, and Primary Sulfonamides J. Am. Chem. Soc. (IF 15.419) Pub Date : 2021-09-17 Pui Kin Tony Lo, Michael C. Willis
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Heterogeneous Isomerization for Stereoselective Alkyne Hydrogenation to trans-Alkene Mediated by Frustrated Hydrogen Atoms J. Am. Chem. Soc. (IF 15.419) Pub Date : 2021-09-17 Weijie Zhang, Ruixuan Qin, Gang Fu, Nanfeng Zheng
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A Mononuclear Non-heme Iron(III)–Peroxo Complex with an Unprecedented High O–O Stretch and Electrophilic Reactivity J. Am. Chem. Soc. (IF 15.419) Pub Date : 2021-09-16 Wenjuan Zhu, Semin Jang, Jin Xiong, Roman Ezhov, Xiao-Xi Li, Taeyeon Kim, Mi Sook Seo, Yong-Min Lee, Yulia Pushkar, Ritimukta Sarangi, Yisong Guo, Wonwoo Nam
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Accessing Photoredox Transformations with an Iron(III) Photosensitizer and Green Light J. Am. Chem. Soc. (IF 15.419) Pub Date : 2021-09-16 Akin Aydogan, Rachel E. Bangle, Alejandro Cadranel, Michael D. Turlington, Daniel T. Conroy, Emilie Cauët, Michael L. Singleton, Gerald J. Meyer, Renato N. Sampaio, Benjamin Elias, Ludovic Troian-Gautier
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Metal-Involving Chalcogen Bond. The Case of Platinum(II) Interaction with Se/Te-Based σ-Hole Donors J. Am. Chem. Soc. (IF 15.419) Pub Date : 2021-09-16 Anton V. Rozhkov, Eugene A. Katlenok, Margarita V. Zhmykhova, Alexander Yu. Ivanov, Maxim L. Kuznetsov, Nadezhda A. Bokach, Vadim Yu. Kukushkin
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Enhanced Polyester Degradation through Transesterification with Salicylates J. Am. Chem. Soc. (IF 15.419) Pub Date : 2021-09-16 Hee Joong Kim, Marc A. Hillmyer, Christopher J. Ellison
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Janus Micelles by Crystallization-Driven Self-Assembly of an Amphiphilic, Double-Crystalline Triblock Terpolymer J. Am. Chem. Soc. (IF 15.419) Pub Date : 2021-09-16 Christian Hils, Joachim Schmelz, Markus Drechsler, Holger Schmalz
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3D Electron Diffraction for Chemical Analysis: Instrumentation Developments and Innovative Applications Chem. Rev. (IF 60.622) Pub Date : 2021-09-17 Tim Gruene, Enrico Mugnaioli
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Directing Coupled Motion with Light: A Key Step Toward Machine-Like Function Chem. Rev. (IF 60.622) Pub Date : 2021-09-17 Romain Costil, Mira Holzheimer, Stefano Crespi, Nadja A. Simeth, Ben L. Feringa
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Artificial Intelligence Applied to Battery Research: Hype or Reality? Chem. Rev. (IF 60.622) Pub Date : 2021-09-16 Teo Lombardo, Marc Duquesnoy, Hassna El-Bouysidy, Fabian Årén, Alfonso Gallo-Bueno, Peter Bjørn Jørgensen, Arghya Bhowmik, Arnaud Demortière, Elixabete Ayerbe, Francisco Alcaide, Marine Reynaud, Javier Carrasco, Alexis Grimaud, Chao Zhang, Tejs Vegge, Patrik Johansson, Alejandro A. Franco
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Para-hydrogen hyperpolarization allows direct NMR detection of α-amino acids in complex (bio)mixtures Angew. Chem. Int. Ed. (IF 15.336) Pub Date : 2021-09-17 Lisanne Sellies, Ruud Aspers, Martin C Feiters, Floris Rutjes, Marco Tessari
The scope of non-hydrogenative para-hydrogen hyperpolarization (PHIP) techniques has been expanding over the last years, with the continuous addition of important classes of substrates. For example, pyruvate can now be hyperpolarized using the Signal Amplification By Reversible Exchange (SABRE) technique, offering a fast, efficient and low-cost PHIP alternative to Dynamic Nuclear Polarization for metabolic
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Influence of Isomerism on Radioluminescence of Purely Organic Phosphorescence Scintillators Angew. Chem. Int. Ed. (IF 15.336) Pub Date : 2021-09-17 Zhongfu An, Chaomin Dong, Xiao Wang, Wenqi Gong, Wenbo Ma, Meng Zhang, Jingjie Li, Yuan Zhang, Zixing Zhou, Zhijian Yang, Shuli Qu, Qian Wang, Zhu Zhao, Guohui Yang, Anqi Lv, Huili Ma, Qiushui Chen, Huifang Shi, Yang (Michael) Yang
There are few reports about purely organic phosphorescence scintillators, and the relationship between molecular structures and radioluminescence in organic scintillators is still unclear. Here, we presented isomerism strategy to study the effect of molecular structures on radioluminescence. The isomers can achieve phosphorescence efficiency of up to 22.8% by ultraviolet irradiation. Under X-ray irradiation
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A Systematic Study of the Effects of Complex Structure on Aryl Iodide Oxidative Addition at Bipyridyl-Ligated Gold(I) Centers Angew. Chem. Int. Ed. (IF 15.336) Pub Date : 2021-09-17 Jamie A. Cadge, John Bower, Christopher A. Russell
A combined theoretical and experimental approach has been used to study the unusual mechanism of oxidative addition of aryl iodides to [bipyAu(C 2 H 4 )] + complexes. The modular nature of this system has allowed a systematic assessment of the effects of complex structure. Computational comparisons between cationic gold and the isolobal (neutral) Pd(0) and Pt(0) complexes revealed similar mechanistic
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Highly Selective Tandem Electroreduction of CO2 to Ethylene over Atomically Isolated Nickel-Nitrogen Site/Copper Nanoparticle Catalysts Angew. Chem. Int. Ed. (IF 15.336) Pub Date : 2021-09-17 Rong Cao, Dong-Li Meng, Meng-Di Zhang, Duan-Hui Si, Min-Jie Mao, Ying Hou, Yuan-Biao Huang
Highly selective CO 2 electroreduction reaction (CO 2 RR) into desired value-added multicarbon products such as C 2 H 4 is of great importance but largely limited by the multi-electron transfer process and sluggish C-C coupling step at one single active site. Herein, an effective tandem catalysis strategy is developed to improve the selectivity of the CO 2 RR towards C 2 H 4 by multiple distinct catalytic
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Supramolecular self-assembled DNA nanosystem for synergistic chemical and gene regulations on cancer cells Angew. Chem. Int. Ed. (IF 15.336) Pub Date : 2021-09-17 Feng Li, Zhaoyue Lv, Xue Zhang, Yuhang Dong, Xiaohui Ding, Zhemian Li, Shuai Li, Chi Yao, Dayong Yang
Incorporating multiple molecular interactions within a system to realize the metabolic reprogramming of cancer cells is prospected to be of great potential in cancer therapy. Herein, we report a supramolecular self-assembled DNA nanosystem, which reprogrammed the cellular antioxidant system via synergistic chemical and gene regulations. In the nanosystem, amphipathic telluroether was coordinated with
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Vertical Graphene Arrays with Straightaway Ions Capacitance for AC Line-Filtering Capacitors Angew. Chem. Int. Ed. (IF 15.336) Pub Date : 2021-09-17 Shichen Xu, Yeye Wen, Zhuo Chen, Nannan Ji, Zhigang Zou, Mingmao Wu, Liangti Qu, Jin Zhang
High-frequency responsive electrochemical capacitor (EC), as an ideal lightweight filtering capacitor, can directly convert alternating current (AC) to direct current (DC) . However, current electrodes are stuck in limited electrode area and tortuous ion transport. Herein, strictly vertical graphene arrays (SVGAs) prepared by electric-field-assisted plasma enhanced chemical vapour deposition have been
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Total Synthesis of Cochlearol B via Intramolecular [2+2] Photocycloaddition Angew. Chem. Int. Ed. (IF 15.336) Pub Date : 2021-09-17 Tomoya Mashiko, Yuta Shingai, Jun Sakai, Shogo Kamo, Shinya Adachi, Akinobu Matsuzawa, Kazuyuki Sugita
Herein, we describe the first total synthesis of cochlearol B, a meroterpenoid natural product featuring a 4/5/6/6/6-fused pentacyclic structure. Key steps, oxidative cyclization and subsequent intramolecular [2+2] photocycloaddition, which constructed the pentacyclic structure in highly stereoselective manner, allowed efficient access to cochlearol B with the longest linear sequence of 16 steps, and
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Controlling gene expression in mammalian cells using multiplexed conditional guide RNAs for Cas12a Angew. Chem. Int. Ed. (IF 15.336) Pub Date : 2021-09-17 Oesinghaus Lukas, Friedrich Christian Simmel
Spatiotemporal control of the activity of CRISPR-associated (Cas) proteins is of considerable interest for basic research and therapeutics. Here, we show that conditional guide RNAs (gRNAs) for Cas12a can be transcribed in mammalian cells by RNA polymerase II, followed by activation via input-dependent processing of the 3’ tail of the gRNA transcript. We demonstrate processing using an RNA strand
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Dense Packing of Acetylene in a Stable and Low-Cost Metal–Organic Framework for Efficient C2H2/CO2 Separation Angew. Chem. Int. Ed. (IF 15.336) Pub Date : 2021-09-16 Banglin Chen, Jiyan Pei, Hui-Min Wen, Xiao-Wen Gu, Quan-Li Qian, Yu Yang, Yuanjing Cui, Bin Li, Guodong Qian
A number of porous materials have been realized for the challenging C 2 H 2 /CO 2 separation with high selectivities; however, most of them suffer from high regeneration energy, poor stability or high cost that largely dampens their industrial implementation. A desired adsorbent should have an optimal balance between excellent separation performance, high stability, and low cost, but such a material
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A General Principle for DUV NLO Materials: π-Conjugated Confinement Enlarges Band Gap Angew. Chem. Int. Ed. (IF 15.336) Pub Date : 2021-09-16 Ling Chen, Lin Xiong, Li-Ming Wu
Current nonlinear optical materials face a conventional limitation in the trade-off between the band gap and birefringence, especially in the deep UV spectral region. To circumvent this dilemma, we propose a general principle, π-conjugated confinement, to partially decouple the interunit π-conjugated interactions by the separation of non-π-conjugated units. The goal is to further enlarge the band gap
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Triggered reversible disassembly of an engineered protein nanocage Angew. Chem. Int. Ed. (IF 15.336) Pub Date : 2021-09-16 Tobias W Giessen, Jesse A. Jones, Ajitha S. Cristie-David, Michael P. Andreas
Protein nanocages play crucial roles in sub-cellular compartmentalization and spatial control in all domains of life and have been used as biomolecular tools for applications in biocatalysis, drug delivery, and bionanotechnology. The ability to control their assembly state under physiological conditions would further expand their practical utility. To gain such control, we introduced a peptide capable
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Enantio- and Diastereodivergent Synthesis of Spirocycles through Dual-Metal-Catalyzed [3+2] Annulation of 2-Vinyloxiranes with Nucleophilic Dipoles Angew. Chem. Int. Ed. (IF 15.336) Pub Date : 2021-09-16 Youbin Peng, Xiaohong Huo, Yicong Luo, Liang Wu, Wanbin Zhang
The development of efficient and straightforward methods for obtaining all optically active isomers of structurally rigid spirocycles from readily available starting materials is of great value in drug discovery and chiral ligand development. However, the stereodivergent synthesis of spirocycles bearing multiple stereocenters remains an unsolved challenge owing to steric hindrance and ring strain.
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Chemoselective and Highly Sensitive Quantification of Gut Microbiome and Human Metabolites Angew. Chem. Int. Ed. (IF 15.336) Pub Date : 2021-08-02 Weifeng Lin, Louis P. Conway, Miroslav Vujasinovic, J.-Matthias Löhr, Daniel Globisch
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Asymmetric Cation-Olefin Monocyclization by Engineered Squalene–Hopene Cyclases Angew. Chem. Int. Ed. (IF 15.336) Pub Date : 2021-08-04 Michael Eichenberger, Sean Hüppi, David Patsch, Natalie Aeberli, Raphael Berweger, Sandro Dossenbach, Eric Eichhorn, Felix Flachsmann, Lucas Hortencio, Francis Voirol, Sabine Vollenweider, Uwe T. Bornscheuer, Rebecca Buller
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Topochemical Ene–Azide Cycloaddition Reaction Angew. Chem. Int. Ed. (IF 15.336) Pub Date : 2021-08-11 Ravichandran Khazeber, Kana M. Sureshan
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Muonium Addition to a peri-Trifluoromethylated 9-Phosphaanthracene Producing a High-Energy Paramagnetic π-Conjugated Fused Heterocycle Angew. Chem. Int. Ed. (IF 15.336) Pub Date : 2021-08-18 Kota Koshino, Kenji M. Kojima, Iain McKenzie, Shigekazu Ito
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Selective Detection of Cu+ Ions in Live Cells via Fluorescence Lifetime Imaging Microscopy Angew. Chem. Int. Ed. (IF 15.336) Pub Date : 2021-08-11 Martin Priessner, Peter A. Summers, Benjamin W. Lewis, Magdalena Sastre, Liming Ying, Marina K. Kuimova, Ramon Vilar
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Designing Anion-Type Water-Free Zn2+ Solvation Structure for Robust Zn Metal Anode Angew. Chem. Int. Ed. (IF 15.336) Pub Date : 2021-08-11 Qiu Zhang, Yilin Ma, Yong Lu, Xunzhu Zhou, Liu Lin, Lin Li, Zhenhua Yan, Qing Zhao, Kai Zhang, Jun Chen
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PtSe2/Pt Heterointerface with Reduced Coordination for Boosted Hydrogen Evolution Reaction Angew. Chem. Int. Ed. (IF 15.336) Pub Date : 2021-08-09 Zongpeng Wang, Beibei Xiao, Zhiping Lin, Yaping Xu, Yan Lin, Fanqi Meng, Qinghua Zhang, Lin Gu, Baizeng Fang, Shaojun Guo, Wenwu Zhong
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Li2MTeO6 (M=Ti, Sn): Mid-Infrared Nonlinear Optical Crystal with Strong Second Harmonic Generation Response and Wide Transparency Range Angew. Chem. Int. Ed. (IF 15.336) Pub Date : 2021-08-30 Xiaoli Du, Xiaojie Guo, Zeliang Gao, Fuan Liu, Feifei Guo, Siyuan Wang, Haoyuan Wang, Youxuan Sun, Xutang Tao
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Sustainable Pd(OAc)2/Hydroquinone Cocatalyst System for Cis-Selective Dibenzoyloxylation of 1,3-Cyclohexadiene Angew. Chem. Int. Ed. (IF 15.336) Pub Date : 2021-08-16 Alexios G. Stamoulis, Peng Geng, Michael A. Schmidt, Martin D. Eastgate, Alina Borovika, Kenneth J. Fraunhoffer, Shannon S. Stahl
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A Copper(I) Complex with Two Unpaired Electrons, Synthesised by Oxidation of a Copper(II) Complex with Two Redox-Active Ligands Angew. Chem. Int. Ed. (IF 15.336) Pub Date : 2021-08-23 Marco Werr, Elisabeth Kaifer, Markus Enders, Andika Asyuda, Michael Zharnikov, Hans-Jörg Himmel
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Biocatalytic C3-Indole Methylation—A Useful Tool for the Natural-Product-Inspired Stereoselective Synthesis of Pyrroloindoles Angew. Chem. Int. Ed. (IF 15.336) Pub Date : 2021-08-16 Pascal Schneider, Birgit Henßen, Beatrix Paschold, Benjamin P. Chapple, Marcel Schatton, Florian P. Seebeck, Thomas Classen, Jörg Pietruszka
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Direct Access to α-Aminosilanes Enabled by Visible-Light-Mediated Multicomponent Radical Cross-Coupling Angew. Chem. Int. Ed. (IF 15.336) Pub Date : 2021-08-25 Xiaoye Yu, Constantin G. Daniliuc, Fatmah Ali Alasmary, Armido Studer
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Discovery and Characterisation of Highly Cooperative FAK-Degrading PROTACs Angew. Chem. Int. Ed. (IF 15.336) Pub Date : 2021-08-20 Robert P. Law, Joao Nunes, Chun-wa Chung, Marcus Bantscheff, Karol Buda, Han Dai, John P. Evans, Adam Flinders, Diana Klimaszewska, Antonia J. Lewis, Marcel Muelbaier, Paul Scott-Stevens, Peter Stacey, Christopher J. Tame, Gillian F. Watt, Nico Zinn, Markus A. Queisser, John D. Harling, Andrew B. Benowitz
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Hierarchically Porous Metal–Organic Framework/MoS2 Interface for Selective Photocatalytic Conversion of CO2 with H2O into CH3COOH Angew. Chem. Int. Ed. (IF 15.336) Pub Date : 2021-08-25 Fengyang Yu, Xu Jing, Yao Wang, Mingyang Sun, Chunying Duan
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Synthesis of Mixed-Valent Lanthanide Sulfide Nanoparticles Angew. Chem. Int. Ed. (IF 15.336) Pub Date : 2021-08-23 Priscilla Glaser, Orlando Stewart, Rida Atif, Dane Romar C. Asuigui, Joel Swanson, Adam J. Biacchi, Angela R. Hight Walker, Gregory Morrison, Hans-Conrad zur Loye, Sarah L. Stoll
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Rational Design of Sustainable Liquid Microcapsules for Spontaneous Fragrance Encapsulation Angew. Chem. Int. Ed. (IF 15.336) Pub Date : 2021-08-06 Marianna Mamusa, Rosangela Mastrangelo, Tom Glen, Sergio Murgia, Gerardo Palazzo, Johan Smets, Piero Baglioni
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Catalytic Carbochlorocarbonylation of Unsaturated Hydrocarbons via C−COCl Bond Cleavage** Angew. Chem. Int. Ed. (IF 15.336) Pub Date : 2021-08-25 Elliott H. Denton, Yong Ho Lee, Sven Roediger, Philip Boehm, Maximilian Fellert, Bill Morandi
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Netting proteins, one at a time Nat. Nanotechnol. (IF 39.213) Pub Date : 2021-09-17 Aleksei Aksimentiev
A leaky DNA origami plug stops protein flow through a nanopore.
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In Science Journals Science (IF 47.728) Pub Date : 2021-09-17 Andrew M. Sugden, Jelena Stajic, Brent Grocholski, Di Jiang, Michael A. Funk, Marc S. Lavine, Michael C. McAlpine, Caitlin Czajka, Gemma Alderton, Seth Thomas Scanlon, Ian S. Osborne, Yury Suleymanov, Priscilla N. Kelly, Claire Olingy, Sacha Vignieri, Annalisa M. VanHook, Yevgeniya Nusinovich
Science, Volume 373, Issue 6561, Page 1319-1321, September 2021.
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Innovation, entrepreneurship, promotion, and tenure Science (IF 47.728) Pub Date : 2021-09-17 Rich G. Carter, Karl Mundorff, Julie Risien, Jana Bouwma-Gearhart, Dawn Bratsch-Prince, Sandra A. Brown, Almesha L. Campbell, Joseph C. Hartman, Charles A. Hasemann, Peter J. Hollenbeck, Blanca Lupiani, Owen J. T. McCarty, Ian D. McClure, Katrina Mealey, Carol Mimura, Andrea J. Romero, Paola Sztajn, Laurie Van Egeren
Science, Volume 373, Issue 6561, Page 1312-1314, September 2021.
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Climate science speaks: “Act now” Science (IF 47.728) Pub Date : 2021-09-17 Jane Lubchenco, John F. Kerry
Science, Volume 373, Issue 6561, Page 1285-1285, September 2021.
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Climate policies loom large in German election Science (IF 47.728) Pub Date : 2021-09-16 Gretchen Vogel
Science, Volume 373, Issue 6561, Page 1298-1299, September 2021.
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Clearing the tinderbox Science (IF 47.728) Pub Date : 2021-09-16 Warren Cornwall
Science, Volume 373, Issue 6561, Page 1300-1303, September 2021.
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U.S. judge acquits researcher charged with hiding China ties Science (IF 47.728) Pub Date : 2021-09-16 Jeffrey Mervis
Science, Volume 373, Issue 6561, Page 1299-1299, September 2021.
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Vaccine equity hopes dashed Science (IF 47.728) Pub Date : 2021-09-16 Jon Cohen
Science, Volume 373, Issue 6561, Page 1297-1297, September 2021.
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Forget oil or water. Icelandic drillers seek magma Science (IF 47.728) Pub Date : 2021-09-16 Paul Voosen
Science, Volume 373, Issue 6561, Page 1296-1297, September 2021.
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‘Zero COVID’ countries seek exit strategies Science (IF 47.728) Pub Date : 2021-09-16 Dennis Normile
Science, Volume 373, Issue 6561, Page 1294-1295, September 2021.
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Schools begin mass testing with vexing questions Science (IF 47.728) Pub Date : 2021-09-16 Jennifer Couzin-Frankel
Science, Volume 373, Issue 6561, Page 1293-1294, September 2021.
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News at a glance Science (IF 47.728) Pub Date : 2021-09-16 Jeffrey Brainard
Science, Volume 373, Issue 6561, Page 1290-1292, September 2021.
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Response to Comments on “Aberrant type 1 immunity drives susceptibility to mucosal fungal infections” Science (IF 47.728) Pub Date : 2021-09-17 Timothy J. Break, Vasileios Oikonomou, Nicolas Dutzan, Jigar V. Desai, Marc Swidergall, Tilo Freiwald, Daniel Chauss, Oliver J. Harrison, Julie Alejo, Drake W. Williams, Stefania Pittaluga, Chyi-Chia R. Lee, Nicolas Bouladoux, Muthulekha Swamydas, Kevin W. Hoffman, Teresa Greenwell-Wild, Vincent M. Bruno, Lindsey B. Rosen, Wint Lwin, Andy Renteria, Sergio M. Pontejo, John P. Shannon, Ian A. Myles,
Puel and Casanova and Kisand et al. challenge our conclusions that interferonopathy and not IL-17/IL-22 autoantibodies promote candidiasis in autoimmune polyendocrinopathy–candidiasis–ectodermal dystrophy. We acknowledge that conclusive evidence for causation is difficult to obtain in complex human diseases. However, our studies clearly document interferonopathy driving mucosal candidiasis with intact
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Institutions’ role in postpandemic support Science (IF 47.728) Pub Date : 2021-09-17 Antoine de Morree, Al’ai Alvarez
Science, Volume 373, Issue 6561, Page 1318-1318, September 2021.
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A flood of disaster response challenges Science (IF 47.728) Pub Date : 2021-09-17 Michael Dietze, Ugur Ozturk
Science, Volume 373, Issue 6561, Page 1317-1318, September 2021.
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Save the white-bellied heron from extinction Science (IF 47.728) Pub Date : 2021-09-17 Gopinathan Maheswaran, Indra Prasad Acharja, Lalit Kumar Sharma, Himadri Sekhar Mondal, Tanoy Mukherjee, Imran Alam, Amitava Majumder
Science, Volume 373, Issue 6561, Page 1317-1317, September 2021.
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Human microphysiological systems for drug development Science (IF 47.728) Pub Date : 2021-09-17 Adrian Roth, MPS-WS Berlin 2019
Science, Volume 373, Issue 6561, Page 1304-1306, September 2021.
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An electron walks into a quantum bar… Science (IF 47.728) Pub Date : 2021-09-17 Fabrizio Carbone
Science, Volume 373, Issue 6561, Page 1309-1310, September 2021.
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Opposing roles of the immune system in tumors Science (IF 47.728) Pub Date : 2021-09-17 Won Jin Ho, Laura D. Wood
Science, Volume 373, Issue 6561, Page 1306-1307, September 2021.
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Homogeneous neuromorphic hardware Science (IF 47.728) Pub Date : 2021-09-17 Feng Rao, Xutang Tao
Science, Volume 373, Issue 6561, Page 1310-1311, September 2021.
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