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Artificial Sodium Channels for Enhanced Osmotic Energy Harvesting J. Am. Chem. Soc. (IF 15.0) Pub Date : 2023-12-01 Qi Li, Ke Zhou, Bin Zhu, Xueli Liu, Junchao Lao, Jun Gao, Lei Jiang
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Modulator-Dependent Dynamics Synergistically Enabled Record SO2 Uptake in Zr(IV) Metal–Organic Frameworks Based on Pyrene-Cored Molecular Quadripod Ligand J. Am. Chem. Soc. (IF 15.0) Pub Date : 2023-12-01 Wei Gong, Yi Xie, Akihito Yamano, Sho Ito, Xianhui Tang, Eric W. Reinheimer, Christos D. Malliakas, Jinqiao Dong, Yong Cui, Omar K. Farha
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Endogenous Metal-Ion Dynamic Nuclear Polarization for NMR Signal Enhancement in Metal Organic Frameworks Chem. Sci. (IF 8.4) Pub Date : 2023-12-02 Ilia B. Moroz, Yishay Feldman, Raanan Carmieli, Xinyu Liu, Michal Leskes
Rational design of metal-organic framework (MOF)-based materials for catalysis, gas capture and storage, requires deep understanding of the host-guest interactions between the MOF and the adsorbed molecules. Solid-State NMR spectroscopy is an established tool for obtaining such structural information, however its low sensitivity limits its application. This limitation can be overcome with dynamic nuclear
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Meta-Lens Particle Image Velocimetry Adv. Mater. (IF 29.4) Pub Date : 2023-12-03 Xiaoyuan Liu, Zhou Zhao, Shengming Xu, Jingcheng Zhang, Yin Zhou, Yulun He, Takeshi Yamaguchi, Hua Ouyang, Takuo Tanaka, Mu Ku Chen, Shengxian Shi, Fei Qi, Din Ping Tsai
Fluid flow behavior is visualized through particle image velocimetry (PIV) for understanding and studying experimental fluid dynamics. However, traditional PIV methods require multiple cameras and conventional lens systems for image acquisition to resolve multi-dimensional velocity fields. In turn, it introduces complexity to the entire system. Meta-lenses are advanced flat optical devices composed
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Photo-Activated Growth and Metastable Phase Transition in Metallic Solid Solutions Adv. Mater. (IF 29.4) Pub Date : 2023-12-02 Andrew Martin, Alana M. Pauls, Boyce Chang, Eva Boyce, Martin Thuo
Laser processing in metals is versatile yet limited by its reliance in phase transformation through heating rather than electronic excitation due to their low absorptivity attributing from their highly ordered structures. Metastable states (i.e., surfaces, glasses, undercooled liquids), however, represent a unique platform, both energetically and structurally to enable energy landscape tuning through
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The overlooked role of landscape dynamics in steering biodiversity Nature (IF 64.8) Pub Date : 2023-11-29 Alexandre Pohl
Physical geography offers a way to explain marine and plant biodiversity.
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Huge survey finds US$10,000 pay gap for disabled scientists Nature (IF 64.8) Pub Date : 2023-11-28
Disabled people with STEM PhDs earn less than their non-disabled colleagues.
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Primary activation of para-quinone methides by chiral phosphoric acid for enantioselective construction of tetraarylmethanes Chem. Sci. (IF 8.4) Pub Date : 2023-12-02 Zhengyu Han, Biao Zhu, Yu Zang, Chaoshen Zhang, Xiu-Qin Dong, Hai Huang, Jianwei Sun
Demonstrated here is an asymmetric nucleophilic addition via primary activation of para-quinone methides (p-QMs) based on chiral phosphoric acid catalytic system. In sharp contrast to those previous CPA-based bifunctional activation processes that all required the nucleophiles to have an effective hydrogen bond donor unit (e.g., OH, NH), here no such unit is required in the nucleophile. N-protected
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Snap-shots of Cluster Growth: Structure and Properties of a Zintl-ion with an Fe3 core, [Fe3Sn18]4-. Chem. Sci. (IF 8.4) Pub Date : 2023-12-02 Zisheng Li, Wei-Xing Chen, Harry William Toriel Morgan, Cong-Cong Shu, John E. McGrady, Zhong-Ming Sun
The endohedral Zintl-ion cluster [Fe3Sn18]4- contains a linear Fe3 core with short Fe-Fe bond lengths of 2.4300(9) Å. The ground state is a septet, with significant σ and π contributions to the Fe-Fe bonds. The Sn18 cage is made up of two partially fused Sn9 fragments, and is structurally intermediate between [Ni2CdSn18]6-, where the fragments are clearly separated and [Pd2Sn18]4-, where they are completely
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Light and endogenous enzyme triggered plasmonic antennas for accurate subcellular molecular imaging with enhanced spatial resolution Chem. Sci. (IF 8.4) Pub Date : 2023-12-02 Shuwei Chen, Yue Yin, Xiaozhe Pang, Congkai Wang, Lei Wang, Junqi Wang, Jiangfei Jia, Xinxue Liu, Shenghao Xu, Xiliang Luo
Developing accurate tumor-specific molecular imaging approaches holds great potential for evaluating cancer progression. However, traditional molecular imaging approaches still suffered from restricted tumor specificity due to the “off-tumor” signal leakage. In this work, we proposed light and endogenous APE1-triggered plasmonic antennas for accurate tumor-specific subcellular molecular imaging with
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A Universal Orthogonal Imaging Platform for Living-Cell RNA Detection using Fluorogenic RNA Aptamers Chem. Sci. (IF 8.4) Pub Date : 2023-12-02 Peng Yin, Mingmin Ge, Shiyi Xie, Li Zhang, Shi Kuang, Zhou Nie
MicroRNAs (miRNAs) are crucial regulators of gene expression at the post-transcriptional level, offering valuable insights into disease mechanisms and prospects for targeted therapeutic interventions. Herein, we present a class of miRNA-induced Light-up RNA Sensors (miLS) that are founded on the toehold mediated principle and employ the fluorogenic RNA aptamers Pepper and Squash as imaging modules
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Lewis acid catalysed polymerisation of cyclopentenone Chem. Sci. (IF 8.4) Pub Date : 2023-12-02 Deepamali Dissanayake, Alysia J. Draper, Zhizhou Liu, Neelofur Jaunnoo, Joris J. Haven, Craig M Forsyth, Alasdair I. McKay, Tanja Junkers, Dragoslav Vidovic
A modest structural change of a β-diketiminate-supported aluminium complex leads to dramatic differences in the reactivity towards cyclopentenone. While the bulkier complex efficiently executes Diels Alder transformations the smaller analogue performs unique polymerisation of this substrate. This observation appears to be unprecedented in the chemistry of Lewis acids and cyclic dienophiles as it represents
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The Structures and Reactivity of NHC-supported Copper(I) Triphenylgermyls Chem. Sci. (IF 8.4) Pub Date : 2023-12-01 Rex S C Charman, Nick J. Evans, Laura E English, Samuel E Neale, Petra Vasko, Mary F. Mahon, David Jonathan Liptrot
Deprotonation of triphenyl germane with NHC-supported copper alkoxides afforded four novel (NHC)CuGePh3 complexes. Of these, (IPr)CuGePh3 (IPr = :C{N(2,6-iPr2C6H3)CH}2) was selected for further investigation. Analysis by EDA-NOCV indicates it to be a germyl nucleophile and its σ-bond metathesis reaction with a range of p-block halides confirmed it to be a convenient source of [Ph3Ge]–. The Cu-Ge bond
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Unusually High-Spin Fe12C12– Metallo-Carbohedrene Clusters J. Am. Chem. Soc. (IF 15.0) Pub Date : 2023-12-02 Lijun Geng, Turbasu Sengupta, Xilong Li, Chaonan Cui, Shiquan Lin, Xi-Ling Xu, Arthur C. Reber, Shiv N. Khanna, Wei-Jun Zheng, Zhixun Luo
Ferromagnets constructed from nanometals of atomic precision are important for innovative advances in information storage, energy conversion, and spintronic microdevices. Considerable success has been achieved in designing molecular magnets, which, however, are challenging in preparation and may suffer from drawbacks on the incompatibility of high stability and strong ferromagnetism. Utilizing a state-of-the-art
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Confinement in Dual-Chain-Locked DNA Origami Nanocages Programs Marker-Responsive Delivery of CRISPR/Cas9 Ribonucleoproteins J. Am. Chem. Soc. (IF 15.0) Pub Date : 2023-12-01 Ziqi Xu, Yuxiang Dong, Ningning Ma, Xurong Zhu, Xue Zhang, Hao Yin, Shiqing Chen, Jun-Jie Zhu, Ye Tian, Qianhao Min
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Palladium-Catalyzed Synthesis of Linked Bis-Heterocycles─Synthesis and Investigation of Photophysical Properties J. Am. Chem. Soc. (IF 15.0) Pub Date : 2023-12-01 Ramon Arora, Bijan Mirabi, Andrew G. Durant, Carlota Bozal-Ginesta, Austin D. Marchese, Alán Aspuru-Guzik, Mark Lautens
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High Flux and Stability of Cationic Intercalation in Transition-Metal Oxides: Unleashing the Potential of Mn t2g Orbital via Enhanced π-Donation J. Am. Chem. Soc. (IF 15.0) Pub Date : 2023-12-01 Shuyun Yao, Shiyu Wang, Yuanming Liu, Zishan Hou, Jinrui Wang, Xueying Gao, Yanfei Sun, Weijie Fu, Kaiqi Nie, Jiangzhou Xie, Zhiyu Yang, Yi-Ming Yan
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Gold–Manganese Bimetallic Redox Coupling with Light J. Am. Chem. Soc. (IF 15.0) Pub Date : 2023-12-01 Siyu Xia, Weipeng Li, Hongliang Chen, Chengjian Zhu, Jie Han, Jin Xie
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Free Halogen Substitution of Chiral Hybrid Metal Halides for Activating the Linear and Nonlinear Chiroptical Properties J. Am. Chem. Soc. (IF 15.0) Pub Date : 2023-12-01 Junjie Guan, Yongshen Zheng, Puxin Cheng, Wenqing Han, Xiao Han, Peihan Wang, Mingyang Xin, Rongchao Shi, Jialiang Xu, Xian-He Bu
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Direct Electrocatalytic Methanol Oxidation on MoO3/Ni(OH)2: Exploiting Synergetic Effect of Adjacent Mo and Ni J. Am. Chem. Soc. (IF 15.0) Pub Date : 2023-12-01 Hui Cheng, Boheng Dong, Qiong Liu, Fuxian Wang
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Machine Learning Accelerated Exploration of Ternary Organic Heterojunction Photocatalysts for Sacrificial Hydrogen Evolution J. Am. Chem. Soc. (IF 15.0) Pub Date : 2023-12-01 Haofan Yang, Yu Che, Andrew I. Cooper, Linjiang Chen, Xiaobo Li
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Chemoselective Esterification of Natural and Prebiotic 1,2-Amino Alcohol Amphiphiles in Water J. Am. Chem. Soc. (IF 15.0) Pub Date : 2023-12-01 Ahanjit Bhattacharya, Lalita Tanwar, Alessandro Fracassi, Roberto J. Brea, Marta Salvador-Castell, Satyam Khanal, Sunil K. Sinha, Neal K. Devaraj
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Bipolar Molecular Torque Wrench Modulates the Stacking of Two-Dimensional Metal–Organic Framework Nanosheets J. Am. Chem. Soc. (IF 15.0) Pub Date : 2023-11-29 Wen-Qi Tang, Xuannuo Yi, Hanxi Guan, Xiao-Wei Wang, Yue-Wen Gu, Ying-Jie Zhao, Jia Fu, Wang Li, Yue Cheng, Sha-Sha Meng, Ming Xu, Qing-Hua Zhang, Lin Gu, Xueqian Kong, Da-Huan Liu, Wei Wang, Zhi-Yuan Gu
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Correlating Structural Disorder in Metal (Oxy)hydroxides and Catalytic Activity in Electrocatalytic Oxygen Evolution Angew. Chem. Int. Ed. (IF 16.6) Pub Date : 2023-12-01 Shouwei Zuo, Zhipeng Wu, Guikai Zhang, Cailing Chen, Yuanfu Ren, Lirong Zheng, Jing Zhang, Yu Han, Huabin Zhang
Understanding the correlation between the structural evolution of electrocatalysts and their catalytic activity is both essential and challenging. In this study, we investigate this correlation in the context of the oxygen evolution reaction (OER) by examining the influence of structural disorder during/after the dynamic structural evolution on their OER activity of Fe-Ni (oxy)hydroxide catalysts using
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Tailored Fluorosurfactants through Controlled/Living Radical Polymerization for Highly Stable Microfluidic Droplet Generation Angew. Chem. Int. Ed. (IF 16.6) Pub Date : 2023-12-01 Xiangke Li, Shi-Yang Tang, Yang Zhang, Jiayuan Zhu, Helen Forgham, Chun-Xia Zhao, Cheng Zhang, Thomas P. Davis, Ruirui Qiao
Droplet-based microfluidics represents a disruptive technology in the field of chemistry and biology through the generation and manipulation of sub-microlitre droplets. To avoid droplet coalescence, fluoropolymer-based surfactants are commonly used to reduce the interfacial tension between two immiscible phases to stabilize droplet interfaces. However, the conventional preparation of fluorosurfactants
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Catalytic Atroposelective Synthesis of Axially Chiral Azomethine Imines and Evaluation of Neuroprotective Activity Angew. Chem. Int. Ed. (IF 16.6) Pub Date : 2023-11-30 Qian-Qian Yang, Chen Chen, Dahong Yao, Wei Liu, Bo Liu, Jin Zhou, Dabo Pan, Cheng Peng, Gu Zhan, Bo Han
Azomethine imines, as a prominent class of 1,3-dipolar species, hold great significance and potential in organic and medicinal chemistry. However, the reported synthesis of central chiral azomethine imines relies on the kinetic resolution, and the construction of axially chiral azomethine imines remains unexplored. In this study, we present the synthesis of axially chiral azomethine imines through
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Preventing Dissolution of Cathode Active Materials by Ion-anchoring Zeolite-based Separators for Durable Aqueous Zinc Batteries Angew. Chem. Int. Ed. (IF 16.6) Pub Date : 2023-11-30 Yao Qin, Xin Wang
Aqueous zinc batteries have emerged as promising energy storage devices due to their safety and low cost. However, they face challenges such as anodic dendrite formation and cathodic compound dissolution. Here, we present the development of a polymer-matrixed zeolite separator (SZ) by synthesizing zeolite materials on a flexible polymeric membrane. This separator acts as an effective ionic barrier
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Click-Chemistry-Mediated Cell Membrane Glycopolymer Engineering to Potentiate Dendritic Cell Vaccines Angew. Chem. Int. Ed. (IF 16.6) Pub Date : 2023-11-29 He Yang, Zijian Xiong, Xingyu Heng, Xiaomeng Niu, Yichen Wang, Lihua Yao, Lele Sun, Zhuang Liu, Hong Chen
Dendritic cell vaccine (DCV) holds great potential in tumor immunotherapy owing to its potent ability in eliciting tumor-specific immune responses. Aiming at engineering enhanced DCV, we report the first effort to construct a glycopolymer-engineered DC vaccine (G-DCV) via metabolic cell surface sugar engineering and copper-free click-chemistry. Model G-DCV was prepared by firstly delivering tumor antigens
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A Nanoinhibitor Targeting cGAS-STING Pathway to Reverse the Homeostatic Imbalance of Inflammation in Psoriasis Angew. Chem. Int. Ed. (IF 16.6) Pub Date : 2023-11-28 Zhibin Zhang, Dongtao Zhou, Zhun Li, Xiaowei Luan, Jingjing Yang, Shaochun Tang, Yujun Song
Psoriasis is a chronic skin inflammation characterized by dysregulated crosstalk between immune cells and keratinocytes. Here we show that the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway is a key regulator of psoriatic inflammation in a mouse model. Platinum-doped positively charged carbon dots (Pt-CDs) were designed to inhibit the cGAS-STING pathway. By inhibiting
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A Highly Bright Near-Infrared Afterglow Luminophore for Activatable Ultrasensitive In Vivo Imaging Angew. Chem. Int. Ed. (IF 16.6) Pub Date : 2023-11-28 Li Yang, Min Zhao, Wan Chen, Jieli Zhu, Weina Xu, Qing Li, Kanyi Pu, Qingqing Miao
Afterglow luminescence imaging probes, with long-lived emission after cessation of light excitation, have drawn increasing attention in biomedical imaging field. However, current afterglow agents always suffer from an unsatisfactory signal intensity and complex systems consisting of multiple ingredients. To address these issues, this study reports a near-infrared (NIR) afterglow luminophore (TPP-DO)
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N-Carbon-Doped Binary Nanophase of Metal Oxide/Metal-Organic Framework for Extremely Sensitive And Selective Gas Response Adv. Mater. (IF 29.4) Pub Date : 2023-12-02 Hyegi Min, Ohchan Kwon, Jihyun Lee, Eunji Choi, Jihee Kim, Nahyeon Lee, Kiwon Eum, Kyu Hyoung Lee, Dae Woo Kim, Wooyoung Lee
Metal-organic frameworks (MOFs), which are highly ordered structures exhibiting sub-nanometer porosity, possess significant potential for diverse gas applications. However, their inherent insulative properties limit their utility in electrochemical gas sensing. This investigation successfully modified the electrical conductivity of zeolitic imidazolte framework-8 (ZIF-8) employing a straightforward
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DNA Nanomaterial-Empowered Surface Engineering of Extracellular Vesicles Adv. Mater. (IF 29.4) Pub Date : 2023-12-02 Xuxiang Yao, Dongdong He, Pengyao Wei, Zitong Niu, Hao Chen, Lin Li, Pan Fu, Yiting Wang, Saiyun Lou, Sihua Qian, Jianping Zheng, Guokun Zuo, Kaizhe Wang
Extracellular vesicles (EVs) are cell-secreted biological nanoparticles that are critical mediators of intercellular communication. They contain diverse bioactive components, which are promising diagnostic biomarkers and therapeutic agents. Their nanosized membrane-bound structures and innate ability to transport functional cargo across major biological barriers make them promising candidates as drug
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Multicrystalline Informatics Applied to Multicrystalline Silicon for Unraveling The Microscopic Root Cause of Dislocation Generation Adv. Mater. (IF 29.4) Pub Date : 2023-12-02 Kenta Yamakoshi, Yutaka Ohno, Kentaro Kutsukake, Takuto Kojima, Tatsuya Yokoi, Hideto Yoshida, Hiroyuki Tanaka, Xin Liu, Hiroaki Kudo, Noritaka Usami
We conducted a comprehensive analysis of optical and photoluminescence images obtained from practical multicrystalline silicon wafers, utilizing various machine learning models for dislocation cluster region extraction, grain segmentation, and crystal orientation prediction. As a result, we were able to build a realistic three-dimensional (3D) model that includes the generation point of dislocation
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Highly Potent and Low-Volume Concentration Additives for Durable Aqueous Zinc Batteries: Machine Learning-Enabled Performance Rationalization Adv. Mater. (IF 29.4) Pub Date : 2023-12-02 Yuan Shang, Varun Kundi, Ipsita Pal, Ha Na Kim, Haoying Zhong, Priyank Kumar, Dipan Kundu
The essential virtues of aqueous zinc battery chemistry stem from the energy-dense zinc metal anode and mild aqueous electrolytes. Yet, their incompatibility – as exposed by zinc's corrosion and associated dendrite problem – poses a challenge to achieving improved cycle life under practically relevant parameters. While electrolyte additives are a scalable strategy, additives that can function at low
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Near-Infrared Nanophosphors Based on CuInSe2 Quantum Dots with Near-Unity Photoluminescence Quantum Yield for Micro-LEDs Applications Adv. Mater. (IF 29.4) Pub Date : 2023-12-02 Wei Lian, Datao Tu, Xukeng Weng, Kaiyu Yang, Fushan Li, Decai Huang, Haomiao Zhu, Zhi Xie, Xueyuan Chen
Highly efficient near-infrared (NIR) luminescent nanomaterials are urgently required for portable mini or micro phosphors-converted light-emitting diodes (pc-LEDs). However, most existing NIR-emitting phosphors are generally restricted by their low photoluminescence (PL) quantum yield (QY) or large particle size. Herein, we develop a kind of highly efficient NIR nanophosphors based on copper indium
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First Observation of Negative Capacitance in Molecular Ferroelectric Thin Films Adv. Mater. (IF 29.4) Pub Date : 2023-12-02 Zi-Jie Feng, Yu-An Xiong, Wen-Cong Sun, Tai-Ting Sha, Jie Yao, Qiang Pan, Huihui Hu, Shuai Dong, Ren-Gen Xiong, Yu-Meng You
On the path of persisting Moore's Law, one of the biggest obstacles is the “Boltzmann tyranny”, which defines the lower limit of power consumption of individual transistors. Negative capacitance in ferroelectrics could provide a solution and has garnered significant attention in the fields of nanoelectronics, materials science, and solid-state physics. Molecular ferroelectrics, as an integral part
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Nanoparticle-Based Bioaffinity Assays:From the research laboratory to the market Adv. Mater. (IF 29.4) Pub Date : 2023-12-01 Zdeněk Farka, Julian C. Brandmeier, Matthias J. Mickert, Matěj Pastucha, Karel Lacina, Petr Skládal, Tero Soukka, Hans H. Gorris
Advances in the development of new biorecognition elements, nanoparticle-based labels as well as instrumentation have inspired the design of new bioaffinity assays. This review critically discusses the potential of nanoparticles to replace current enzymatic or molecular labels in immunoassays and other bioaffinity assays. We highlight successful implementations of nanoparticles in commercial assays
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Heterojunction Engineering of Multinary Metal Sulfide-Based Photocatalysts for Efficient Photocatalytic Hydrogen Evolution Adv. Mater. (IF 29.4) Pub Date : 2023-12-01 Yiming Song, Xinlong Zheng, Yuqi Yang, Yuhao Liu, Jing Li, Daoxiong Wu, Weifeng Liu, Yijun Shen, Xinlong Tian
Photocatalytic hydrogen evolution (PHE) via water splitting using semiconductor photocatalysts is an effective path to solve the current energy crisis and environmental pollution. Heterojunction photocatalysts, containing two or more semiconductors, exhibit better PHE rates than those with only one semiconductor owing to the altered band alignment at the interface and stronger driving force for charge
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Near-infrared Chemiluminescence Imaging of Chemotherapy-induced Peripheral Neuropathy Adv. Mater. (IF 29.4) Pub Date : 2023-12-01 Jing Liu, Jingsheng Huang, Xin Wei, Penghui Cheng, Kanyi Pu
Chemotherapy-induced peripheral neuropathy (CIPN) has a high prevalence but is poorly managed for cancer patients due to the lack of reliable and sensitive diagnostic techniques. Molecular optical imaging can provide a noninvasive way for real-time monitoring of CIPN. However, this has not been reported, likely due to the absence of optical probes capable of imaging deep into the spinal canal and possessing
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Efficient Flow Synthesis of Aspirin Within 2d Sub-Nanoconfined Laminar Annealed Graphene Oxide Membranes Adv. Mater. (IF 29.4) Pub Date : 2023-12-01 Xiang Li, Shuai Pang, Yuhui Zhang, Jiangwei Fu, Guandi He, Bo Song, Daoling Peng, Xiqi Zhang, Lei Jiang
The aim of this work is to develop an environmentally friendly, safe, and simple route for realizing efficient preparation of aspirin. Here, inspired by enzyme synthesis in vivo, we have realized the aspirin synthesis by sub-nanoconfined esterification with directional flow and ∼100% conversion in an unprecedented reaction time of <6.36 s at 23°C. Such flow esterification reaction is catalyzed by thermally
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Time-resolved fluorescence imaging with color-changing, “turn-on/turn-on” AIE nanoparticles Chem (IF 23.5) Pub Date : 2023-12-01 Adam F. Henwood, Niamh Curtin, Sandra Estalayo-Adrián, Aramballi J. Savyasachi, Tómas A. Gudmundsson, June I. Lovitt, L. Constance Sigurvinsson, Hannah L. Dalton, Chris S. Hawes, Denis Jacquemin, Donal F. O’Shea, Thorfinnur Gunnlaugsson
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Structural Color from Cellulose Nanocrystals or Chitin Nanocrystals: Self-Assembly, Optics, and Applications Chem. Rev. (IF 62.1) Pub Date : 2023-11-27 Bruno Frka-Petesic, Thomas G. Parton, Camila Honorato-Rios, Aurimas Narkevicius, Kevin Ballu, Qingchen Shen, Zihao Lu, Yu Ogawa, Johannes S. Haataja, Benjamin E. Droguet, Richard M. Parker, Silvia Vignolini
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Disability lawsuit lands Howard Hughes Medical Institute in court Nature (IF 64.8) Pub Date : 2023-12-02
RNA biologist Vivian Cheung accuses the institute of discrimination after it rejected her grant-renewal bid.
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Tinkering with immune cells gives cancer treatment a boost Nature (IF 64.8) Pub Date : 2023-12-01
Tumours respond more readily to radiation and other therapies in mice without a specific protein in their dendritic cells.
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How to create compelling scientific data visualisations Nature (IF 64.8) Pub Date : 2023-12-01
Start with pen and paper, keep things simple, do your coding at the end, say data visualisation specialists.
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Approaching 1.5 °C: how will we know we’ve reached this crucial warming mark? Nature (IF 64.8) Pub Date : 2023-12-01 Richard A. Betts, Stephen E. Belcher, Leon Hermanson, Albert Klein Tank, Jason A. Lowe, Chris D. Jones, Colin P. Morice, Nick A. Rayner, Adam A. Scaife, Peter A. Stott
Assessing global mean temperature rise using the average warming over the previous one or two decades will delay formal recognition of when Earth breaches the Paris agreement’s 1.5 °C guard rail. Here is what’s needed to avoid the wait.
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Climate change is also a health crisis — these 3 graphics explain why Nature (IF 64.8) Pub Date : 2023-12-01
Health is on the agenda at the COP28 climate meeting. Rising temperatures increase the spread of infectious diseases, claim lives and drive food insecurity.
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Microbiologists at COP28 push for a seat at the climate-policy table Nature (IF 64.8) Pub Date : 2023-11-30
At this week’s big climate summit and beyond, scientists are campaigning for microbes to be included in climate models and solutions.
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Ending extreme poverty has a negligible impact on global greenhouse gas emissions Nature (IF 64.8) Pub Date : 2023-11-29 Philip Wollburg, Stephane Hallegatte, Daniel Gerszon Mahler
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Pesticide use negatively affects bumble bees across European landscapes Nature (IF 64.8) Pub Date : 2023-11-29 Charlie C. Nicholson, Jessica Knapp, Tomasz Kiljanek, Matthias Albrecht, Marie-Pierre Chauzat, Cecilia Costa, Pilar De la Rúa, Alexandra-Maria Klein, Marika Mänd, Simon G. Potts, Oliver Schweiger, Irene Bottero, Elena Cini, Joachim R. de Miranda, Gennaro Di Prisco, Christophe Dominik, Simon Hodge, Vera Kaunath, Anina Knauer, Marion Laurent, Vicente Martínez-López, Piotr Medrzycki, Maria Helena Pereira-Peixoto
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Remote collaboration fuses fewer breakthrough ideas Nature (IF 64.8) Pub Date : 2023-11-29 Yiling Lin, Carl Benedikt Frey, Lingfei Wu
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Daily briefing: Why volunteers want to be infected with disease to progress vaccines Nature (IF 64.8) Pub Date : 2023-11-29
An advocacy group is pushing for more ‘human challenge’ trials to aid research. Plus, sparrows nearly double part of their brains to sing better during mating season and COP28 president denies pushing oil deals at climate summit.
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Serotonin 2A Receptor (5-HT2AR) Agonists: Psychedelics and Non-Hallucinogenic Analogues as Emerging Antidepressants Chem. Rev. (IF 62.1) Pub Date : 2023-11-30 Wenwen Duan, Dongmei Cao, Sheng Wang, Jianjun Cheng
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Monitoring The Synthesis of Neutral Lipids in Lipid Droplets of Living Human Cancer Cells using Two-color Infrared Photothermal Microscopy Chem. Sci. (IF 8.4) Pub Date : 2023-12-01 Chanjong Park, Jong Min Lim, Seok-Cheol Hong, Minhaeng Cho
There has been a growing interest in the functions of lipid droplets (LDs) due to recent discoveries regarding their diverse roles. These functions encompass lipid metabolism, regulation of lipotoxicity, and signaling pathways that extend beyond their traditional role in energy storage. Consequently, there is a need to examine the molecular dynamics of LDs at the subcellular level. Two-color Infrared
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The Minimum Protein Staple? – Towards ‘bio’-Baldwin’s Rules via Inter-phosphosite Linking in the MEK1 Activation Loop Chem. Sci. (IF 8.4) Pub Date : 2023-12-01 Sébastien Galan, Ritu Raj, Dimitrios Mamalis, Lyn H Jones, Shabaz Mohammed, Benjamin G Davis
In small molecule organic chemistry the heuristic insight into ring-forming processes that was enabled by Baldwin’s rules some 50 years ago proved a step-change in the role of mechanistically guided synthesis. It created a lens upon and marker of fundamental stereoelectronic and conformation-guided chemical processes. However, despite the widespread role of stereoelectronics and conformational control
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High-aspect-ratio nanostructured hydroxyapatite: towards new functionalities for a classical material Chem. Sci. (IF 8.4) Pub Date : 2023-12-01 Anna Diez-Escudero, Montserrat Espanol, Maria-Pau Ginebra
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MOF (UiO-66-NH2)@COF (TFP-TABQ) Hybrids via On-surface Condensation Reactions for Sustainable Energy Storage Chem. Commun. (IF 4.9) Pub Date : 2023-12-01 Dawid Pakulski, Verónica Montes-García, Wlodzimierz Czepa, Dawid Marcinkowski, Haijun Peng, Tomasz Chudziak, Adam Gorczyński, Wojciech Kukułka, Cataldo Valentini, Violetta Patroniak, Paolo Samorì, Artur Ciesielski
Core-shell MOF@COF hybrids were synthesized via subsequent modification of MOF UiO-66-NH2 with 1,3,5-triformylphloroglucinol (TFP) and 2,3,5,6-tetraaminobenzoquinone (TABQ). The hybrids exhibited significant surface area (236m2/g) and outstanding electrochemical performance (103F/g at 0.5A/g), surpassing both COFs and MOFs, thereby showcasing the potential of on-surface condensation reactions for developing
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A DNA rotary nanodevice operated by enzyme-initiated strand resetting Chem. Commun. (IF 4.9) Pub Date : 2023-12-01 Arun Richard Chandrasekaran
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Chronological Development of Functional Fluorophores for Bio-Imaging Chem. Commun. (IF 4.9) Pub Date : 2023-12-01 Subrata Munan, Young-Tae Chang, Animesh Samanta
Functional fluorophores represent an emerging research field, distinguished by their diverse applications, especially in sensing and cellular imaging. After the discovery of Quinine sulfate and subsequent elucidation of the fluorescence mechanism by Sir George Stokes, research in the field of fluorescence gained momentum. Over the past few decades, advancements in sophisticated instruments, including
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Mixed-magnesium/zinc calix[4]arene complexes: Structure, and ring opening polymerisation studies Chem. Commun. (IF 4.9) Pub Date : 2023-12-01 Henry J.S. Banks, Josef Frese, Mark Robert James Elsegood, Carl Redshaw
Different combinations of organomagnesium reagents and zinc bromide react with either 1,3-dimethoxy-4-tert-butylcalix[4]areneH2 (L(OMe)2H2) or trialkoxycalix[4]arenes (L(OR)3H) (R = n-Pr, n-pentyl) to afford mixed-metal calix[4]arene systems. Intruiging molecular structures are formed and the systems are capable of the ring opening polymerisation of ε-caprolactone under N2, air, or as melts.