Catalytic enantioselective synthesis of tetrahydrofurans, which are found in the structures of many biologically active natural products, via a transition-metal catalyzed-hydrogen atom transfer (TM-HAT) and radical-polar crossover (RPC) mechanism is described herein. Hydroalkoxylation of non-conjugated alkenes proceeded efficiently with excellent enantioselectivity (up to 94% ee) using a suitable chiral

Cyclo[18]carbon (C18, a molecular carbon allotrope) can be synthesized by dehalogenation of a bromocyclocarbon precursor, C18Br6, in 64% yield, by atomic manipulation on a sodium chloride bilayer on Cu(111) at 5 K, and imaged by high-resolution atomic force microscopy. This method of generating C18 gives a higher yield than that reported previously from the cyclocarbon oxide C24O6. The experimental

ABSTRACT: Quantum entanglement has been shown to imply correlations stronger than those allowed by classical models. The possibility of performing tasks, which are classically impossible has made quantum entanglement a powerful resource for the development of novel methods and applications in various fields of research such as quantum computing, quantum cryptography, and quantum metrology. There is

We have prepared a photoresponsive metal-organic framework by using an amide-based [2]rotaxane as linker and copper(II) ions as metal nodes. The interlocked linker was obtained by the hydrogen bond-directed approach employing a fumaramide thread as template of the macrocyclic component, this latter incorporating two carboxyl groups. Single crystal X-ray diffraction analysis of the metal-organic framework

While the icosahedral closo-[B12H12]2– cluster does not display reversible electrochemical behavior, perfunctionalization of this species via substitution of all twelve B–H vertices with alkoxy or benzyloxy (OR) substituents engenders reversible redox chemistry, providing access to clusters in the dianionic, monoanionic, and neutral forms. Here, we evaluated the elec-trochemical behavior of the electron-rich

Three-dimensional (3D) triply interlocked catenanes are a family of chemical topologies that consist of two identical, mechanically interlocked coordination cage components with intriguingly complex structures. Although only a few successful constructions of 3D interlocked catenanes have been achieved to date via metal-mediated assembly, these complex structures have thus far only been targeted by

The gap between fundamental academic research and the applied industrial research that is necessary to ensure real-world applications can be bridged by engaging in well-defined collaborative academia–industry projects and fostering better communication between the scientists involved in them.

The Plasmodium species that cause malaria are obligate intracellular parasites, and disease symptoms occur as they replicate within human blood. Despite risking immune detection, the parasite delivers proteins that bind host receptors to infected erythrocyte surfaces. In the causative agent of the most deadly human malaria, Plasmodium falciparum, RIFINs form the largest erythrocyte surface protein

The World Health Organization is sending scientists to China this weekend to investigate the origins of the COVID-19 outbreak.

Economists welcome the chance to see whether giving people cash to spend however they choose improves livelihoods.

Spain launches the largest test yet of no-strings-attached income — but it’s not truly universal. Plus: how group testing could transform the hunt for coronavirus cases, and PhD students in Australia face financial meltdown.

Four charts show how pooling samples from many people can save time or resources.

Tracking how people move around urban areas can pinpoint where disease might transmit fastest and farthest.

Workouts rejuvenate the brains of old mice — but so does plasma from well-conditioned rodents.

A new family of phosphine‐ligated dicyanoarylgold(III) complexes has been prepared and their reactivity towards reductive elimination has been studied in detail. Both, a highly positive entropy of activation and a primary 12/13 C KIE suggest a late concerted transition state while Hammett analysis and DFT calculations indicate that the process is asynchronous. As a result, a distinct mechanism involving

Ti silicates, and in particular Titanium Silicalite‐1 (TS‐1), are nowadays important catalysts for several partial oxidation reactions in the presence of aqueous H 2 O 2 as oxidant. Despite the numerous studies dealing with this material, some fundamental aspects are still unfathomed. In particular, the structure and the catalytic role of defective Ti sites, other than perfect tetrahedral sites recognized

The reaction of hexachlorophosphazene, P3N3Cl6, with SO3 leads to the new sulfur nitride‐oxide S6N2O15. The compound displays an extraordinarily low nitrogen content and exhibits a bicyclic cage structure according to the formulation N{S(O)2O(O)2S}3N, with both nitrogen atoms in trigonal planar coordination of sulfur atoms. Interestingly, the new nitride‐oxide can be also seen as the anhydride of

Porosity and acidity are influential properties in the rational design of solid‐acid catalysts. Probing the physicochemical characteristics of an acidic zeotype framework at the molecular level can provide valuable insights in understanding intrinsic reaction pathways, for affording structure‐activity relationships. Herein, we employ a variety of probe‐based techniques (including positron annihilation

Multi‐component MOFs contain multiple sets of unique and hierarchical pores, with different functions for different applications, distributed in their inter‐linked domains. Herein, we report the construction of a class of precisely aligned flexible‐on‐rigid hybrid‐phase MOFs with unique rods‐on‐octahedron morphology. We demonstrated that hybrid‐phase MOFs can be constructed based on two prerequisites:

While the art of DNA origami has been investigated extensively in recent years and demonstrated to work in a reliable manner, precise engineering of such patterns with polymers represents an emerging topic. Compared to conventional top‐down approaches ( i.e. lithography) or bottom‐up functionalization tech­niques ( i.e. self‐assembly), the com­bination of DNA origami nano­structures and polymers pro­vides

A conceptually novel approach is described for the synthesis of six‐membered cyclic carbonates derived from carbon dioxide. The approach utilizes homoallylic precursors that are converted into five‐membered cyclic carbonates having a beta‐positioned alcohol group in one of the ring substituents. The activation of the pendent alcohol group through an N ‐heterocyclic base allows for equilibration towards

Gastrin‐releasing peptide receptor (GRPr) plays proliferative and inflammatory roles in living systems. Here, we report a highly selective GRPr antagonist (JMV594)‐tethered iridium(III) complex for probing GRPr in living cancer cells and immune cells. This probe not only exhibited desirable photophysical properties, but also displayed negligible cytotoxicity, overcoming the inherent toxicity of the

Non‐centrosymmetric polar compounds have important technological properties. Reported perovskite oxynitrides show centrosymmetric structures and for some of them high permittivities have been observed, ascribed to local dipoles induced by partial order of nitride and oxide. Here we report the first hexagonal perovskite oxynitride BaWON2, that shows a polar 6H polytype. Synchrotron X‐ray and neutron

The Zintl anion (Ge 2 As 2 ) 2− represents an isostructural and isoelectronic binary counterpart of yellow arsenic, yet without being studied with the same intensity so far. Upon introducing [(PPh 3 )AuMe] into the 1,2‐diaminoethane (en) solution of (Ge 2 As 2 ) 2− , the heterometallic cluster anion [Au 6 (Ge 3 As)(Ge 2 As 2 ) 3 ] 3− is obtained as its salt [K(crypt‐222)] 3 [Au 6 (Ge 3 As)(Ge 2 As

Efficient electron communication between molecular catalyst and support is critical for heterogeneous molecular electrocatalysis and yet it is often overlooked during the catalyst design. Taking CO 2 electro‐reduction on tetraphenylporphyrin cobalt (PCo) immobilized onto graphene as an example, we demonstrate that adding a relay molecule improves the interfacial electron communication. While the directly

Herein, we introduce the cyclic 8π‐electron (C8π) molecule N , N ′‐diaryl‐dihydrodibenzo[ a , c ]phenazines ( DPAC ) as a dual‐functional donor to establish a series of new donor‐linker‐acceptor (D‐L‐A) dyads DLA1 ~ DLA5 . The excited‐state bent‐to‐planar dynamics of DPAC regulate the donor’s energy gap, while the acceptors A1 ~ A5 are endowed with different energy gaps and HOMO/LUMO levels. As a result

Dynamic and on‐site analysis of serum from human blood is crucial particularly for making decisions during clinical surgery and emergency treatments. However, state‐of‐the‐art blood assay methods can only collect single or discrete data of physiological analytes, remaining great challenge in online report of dynamic fluctuation of key analytes. Here we propose a novel separation–sensing membrane by

Growth of covalent organic frameworks (COFs) as single crystals is extremely challenging. Inaccessibility of open‐structured single‐crystal COFs prevents the exploration of structure‐oriented applications. Herein we report for the first time a non‐interpenetrated single‐crystal COF, LZU‐306, which possesses the open structure constructed exclusively via covalent assembly. With a high void volume of

Mesoporous core‐shell nanostructures holding controllable ultra‐large open channels in their nanoshells are of great interests for the development of new catalytic platforms, electrochemical energy systems, and biological macromolecular carriers. However, soft template‐directed cooperative assembly to mesoporous nanoshells with highly accessible pores larger than 30 nm, or even above 50 nm into macroporous

Lantibiotics are a type of ribosomally synthesized and post‐translationally modified peptides (termed lanthipeptides) with often potent antimicrobial activity. Herein, we report the discovery of a new lantibiotic, lexapeptide, using the Library EXpression Analysis System (LEXAS) approach. Lexapeptide has rare structural modifications, including N‐terminal (N,N)‐dimethyl phenylalanine, C‐terminal (

Lead‐free halide perovskite of A 3 Sb 2 Br 9 is utilized as photocatalyst for the first time to C (sp 3 )‐H bonds activation. A 3 Sb 2 Br 9 nanoparticles (A 3 Sb 2 Br 9 NPs) with different ratios of Cs and MA show different photocatalytic activity for toluene oxidation and the photocatalytic performance is enhanced when increasing the amount of Cs. We reveal that the octahedron distortion caused by

In soft matter, thermal energy causes molecules to continuously translate and rotate, even in crowded environments, thereby impacting the spatial organization and function of most molecular assemblies, such as lipid membranes. Directly measuring the orientation and spatial organization of large collections (>3000 molecules/µm 2 ) of single molecules with nanoscale resolution remains elusive. In this

As coronavirus disease 2019 (COVID-19) is rapidly spreading across the globe, short-term modeling forecasts provide time-critical information for decisions on containment and mitigation strategies. A major challenge for short-term forecasts is the assessment of key epidemiological parameters and how they change when first interventions show an effect. By combining an established epidemiological model

Marine invertebrate ascidians display embryonic reproducibility: Their early embryonic cell lineages are considered invariant and are conserved between distantly related species, despite rapid genomic divergence. Here, we address the drivers of this reproducibility. We used light-sheet imaging and automated cell segmentation and tracking procedures to systematically quantify the behavior of individual

Cerebrospinal fluid (CSF) is a vital liquid, providing nutrients and signaling molecules and clearing out toxic by-products from the brain. The CSF is produced by the choroid plexus (ChP), a protective epithelial barrier that also prevents free entry of toxic molecules or drugs from the blood. Here, we establish human ChP organoids with a selective barrier and CSF-like fluid secretion in self-contained

The general functions of lymphatic vessels in fluid transport and immunosurveillance are well recognized. However, accumulating evidence indicates that lymphatic vessels play active and versatile roles in a tissue- and organ-specific manner during homeostasis and in multiple disease processes. This Review discusses recent advances to understand previously unidentified functions of adult mammalian lymphatic

The dentitions of extant fishes and land vertebrates vary in both pattern and type of tooth replacement. It has been argued that the common ancestral condition likely resembles the nonmarginal, radially arranged tooth files of arthrodires, an early group of armoured fishes. We used synchrotron microtomography to describe the fossil dentitions of so-called acanthothoracids, the most phylogenetically

France has been heavily affected by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic and went into lockdown on 17 March 2020. Using models applied to hospital and death data, we estimate the impact of the lockdown and current population immunity. We find that 2.9% of infected individuals are hospitalized and 0.5% of those infected die (95% credible interval: 0.3 to 0.9%), ranging