Rational design of metal-organic framework (MOF)-based materials for catalysis, gas capture and storage, requires deep understanding of the host-guest interactions between the MOF and the adsorbed molecules. Solid-State NMR spectroscopy is an established tool for obtaining such structural information, however its low sensitivity limits its application. This limitation can be overcome with dynamic nuclear

Fluid flow behavior is visualized through particle image velocimetry (PIV) for understanding and studying experimental fluid dynamics. However, traditional PIV methods require multiple cameras and conventional lens systems for image acquisition to resolve multi-dimensional velocity fields. In turn, it introduces complexity to the entire system. Meta-lenses are advanced flat optical devices composed

Laser processing in metals is versatile yet limited by its reliance in phase transformation through heating rather than electronic excitation due to their low absorptivity attributing from their highly ordered structures. Metastable states (i.e., surfaces, glasses, undercooled liquids), however, represent a unique platform, both energetically and structurally to enable energy landscape tuning through

Physical geography offers a way to explain marine and plant biodiversity.

Disabled people with STEM PhDs earn less than their non-disabled colleagues.

Demonstrated here is an asymmetric nucleophilic addition via primary activation of para-quinone methides (p-QMs) based on chiral phosphoric acid catalytic system. In sharp contrast to those previous CPA-based bifunctional activation processes that all required the nucleophiles to have an effective hydrogen bond donor unit (e.g., OH, NH), here no such unit is required in the nucleophile. N-protected

The endohedral Zintl-ion cluster [Fe3Sn18]4- contains a linear Fe3 core with short Fe-Fe bond lengths of 2.4300(9) Å. The ground state is a septet, with significant σ and π contributions to the Fe-Fe bonds. The Sn18 cage is made up of two partially fused Sn9 fragments, and is structurally intermediate between [Ni2CdSn18]6-, where the fragments are clearly separated and [Pd2Sn18]4-, where they are completely

Developing accurate tumor-specific molecular imaging approaches holds great potential for evaluating cancer progression. However, traditional molecular imaging approaches still suffered from restricted tumor specificity due to the “off-tumor” signal leakage. In this work, we proposed light and endogenous APE1-triggered plasmonic antennas for accurate tumor-specific subcellular molecular imaging with

MicroRNAs (miRNAs) are crucial regulators of gene expression at the post-transcriptional level, offering valuable insights into disease mechanisms and prospects for targeted therapeutic interventions. Herein, we present a class of miRNA-induced Light-up RNA Sensors (miLS) that are founded on the toehold mediated principle and employ the fluorogenic RNA aptamers Pepper and Squash as imaging modules

A modest structural change of a β-diketiminate-supported aluminium complex leads to dramatic differences in the reactivity towards cyclopentenone. While the bulkier complex efficiently executes Diels Alder transformations the smaller analogue performs unique polymerisation of this substrate. This observation appears to be unprecedented in the chemistry of Lewis acids and cyclic dienophiles as it represents

Deprotonation of triphenyl germane with NHC-supported copper alkoxides afforded four novel (NHC)CuGePh3 complexes. Of these, (IPr)CuGePh3 (IPr = :C{N(2,6-iPr2C6H3)CH}2) was selected for further investigation. Analysis by EDA-NOCV indicates it to be a germyl nucleophile and its σ-bond metathesis reaction with a range of p-block halides confirmed it to be a convenient source of [Ph3Ge]–. The Cu-Ge bond

Ferromagnets constructed from nanometals of atomic precision are important for innovative advances in information storage, energy conversion, and spintronic microdevices. Considerable success has been achieved in designing molecular magnets, which, however, are challenging in preparation and may suffer from drawbacks on the incompatibility of high stability and strong ferromagnetism. Utilizing a state-of-the-art

Understanding the correlation between the structural evolution of electrocatalysts and their catalytic activity is both essential and challenging. In this study, we investigate this correlation in the context of the oxygen evolution reaction (OER) by examining the influence of structural disorder during/after the dynamic structural evolution on their OER activity of Fe-Ni (oxy)hydroxide catalysts using

Droplet-based microfluidics represents a disruptive technology in the field of chemistry and biology through the generation and manipulation of sub-microlitre droplets. To avoid droplet coalescence, fluoropolymer-based surfactants are commonly used to reduce the interfacial tension between two immiscible phases to stabilize droplet interfaces. However, the conventional preparation of fluorosurfactants

Azomethine imines, as a prominent class of 1,3-dipolar species, hold great significance and potential in organic and medicinal chemistry. However, the reported synthesis of central chiral azomethine imines relies on the kinetic resolution, and the construction of axially chiral azomethine imines remains unexplored. In this study, we present the synthesis of axially chiral azomethine imines through

Aqueous zinc batteries have emerged as promising energy storage devices due to their safety and low cost. However, they face challenges such as anodic dendrite formation and cathodic compound dissolution. Here, we present the development of a polymer-matrixed zeolite separator (SZ) by synthesizing zeolite materials on a flexible polymeric membrane. This separator acts as an effective ionic barrier

Dendritic cell vaccine (DCV) holds great potential in tumor immunotherapy owing to its potent ability in eliciting tumor-specific immune responses. Aiming at engineering enhanced DCV, we report the first effort to construct a glycopolymer-engineered DC vaccine (G-DCV) via metabolic cell surface sugar engineering and copper-free click-chemistry. Model G-DCV was prepared by firstly delivering tumor antigens

Psoriasis is a chronic skin inflammation characterized by dysregulated crosstalk between immune cells and keratinocytes. Here we show that the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway is a key regulator of psoriatic inflammation in a mouse model. Platinum-doped positively charged carbon dots (Pt-CDs) were designed to inhibit the cGAS-STING pathway. By inhibiting

Afterglow luminescence imaging probes, with long-lived emission after cessation of light excitation, have drawn increasing attention in biomedical imaging field. However, current afterglow agents always suffer from an unsatisfactory signal intensity and complex systems consisting of multiple ingredients. To address these issues, this study reports a near-infrared (NIR) afterglow luminophore (TPP-DO)

Metal-organic frameworks (MOFs), which are highly ordered structures exhibiting sub-nanometer porosity, possess significant potential for diverse gas applications. However, their inherent insulative properties limit their utility in electrochemical gas sensing. This investigation successfully modified the electrical conductivity of zeolitic imidazolte framework-8 (ZIF-8) employing a straightforward

Extracellular vesicles (EVs) are cell-secreted biological nanoparticles that are critical mediators of intercellular communication. They contain diverse bioactive components, which are promising diagnostic biomarkers and therapeutic agents. Their nanosized membrane-bound structures and innate ability to transport functional cargo across major biological barriers make them promising candidates as drug

We conducted a comprehensive analysis of optical and photoluminescence images obtained from practical multicrystalline silicon wafers, utilizing various machine learning models for dislocation cluster region extraction, grain segmentation, and crystal orientation prediction. As a result, we were able to build a realistic three-dimensional (3D) model that includes the generation point of dislocation

The essential virtues of aqueous zinc battery chemistry stem from the energy-dense zinc metal anode and mild aqueous electrolytes. Yet, their incompatibility – as exposed by zinc's corrosion and associated dendrite problem – poses a challenge to achieving improved cycle life under practically relevant parameters. While electrolyte additives are a scalable strategy, additives that can function at low

Highly efficient near-infrared (NIR) luminescent nanomaterials are urgently required for portable mini or micro phosphors-converted light-emitting diodes (pc-LEDs). However, most existing NIR-emitting phosphors are generally restricted by their low photoluminescence (PL) quantum yield (QY) or large particle size. Herein, we develop a kind of highly efficient NIR nanophosphors based on copper indium

On the path of persisting Moore's Law, one of the biggest obstacles is the “Boltzmann tyranny”, which defines the lower limit of power consumption of individual transistors. Negative capacitance in ferroelectrics could provide a solution and has garnered significant attention in the fields of nanoelectronics, materials science, and solid-state physics. Molecular ferroelectrics, as an integral part

Advances in the development of new biorecognition elements, nanoparticle-based labels as well as instrumentation have inspired the design of new bioaffinity assays. This review critically discusses the potential of nanoparticles to replace current enzymatic or molecular labels in immunoassays and other bioaffinity assays. We highlight successful implementations of nanoparticles in commercial assays

Photocatalytic hydrogen evolution (PHE) via water splitting using semiconductor photocatalysts is an effective path to solve the current energy crisis and environmental pollution. Heterojunction photocatalysts, containing two or more semiconductors, exhibit better PHE rates than those with only one semiconductor owing to the altered band alignment at the interface and stronger driving force for charge

Chemotherapy-induced peripheral neuropathy (CIPN) has a high prevalence but is poorly managed for cancer patients due to the lack of reliable and sensitive diagnostic techniques. Molecular optical imaging can provide a noninvasive way for real-time monitoring of CIPN. However, this has not been reported, likely due to the absence of optical probes capable of imaging deep into the spinal canal and possessing

The aim of this work is to develop an environmentally friendly, safe, and simple route for realizing efficient preparation of aspirin. Here, inspired by enzyme synthesis in vivo, we have realized the aspirin synthesis by sub-nanoconfined esterification with directional flow and ∼100% conversion in an unprecedented reaction time of <6.36 s at 23°C. Such flow esterification reaction is catalyzed by thermally

RNA biologist Vivian Cheung accuses the institute of discrimination after it rejected her grant-renewal bid.

Tumours respond more readily to radiation and other therapies in mice without a specific protein in their dendritic cells.

Start with pen and paper, keep things simple, do your coding at the end, say data visualisation specialists.

Assessing global mean temperature rise using the average warming over the previous one or two decades will delay formal recognition of when Earth breaches the Paris agreement’s 1.5 °C guard rail. Here is what’s needed to avoid the wait.

Health is on the agenda at the COP28 climate meeting. Rising temperatures increase the spread of infectious diseases, claim lives and drive food insecurity.

At this week’s big climate summit and beyond, scientists are campaigning for microbes to be included in climate models and solutions.

An advocacy group is pushing for more ‘human challenge’ trials to aid research. Plus, sparrows nearly double part of their brains to sing better during mating season and COP28 president denies pushing oil deals at climate summit.

There has been a growing interest in the functions of lipid droplets (LDs) due to recent discoveries regarding their diverse roles. These functions encompass lipid metabolism, regulation of lipotoxicity, and signaling pathways that extend beyond their traditional role in energy storage. Consequently, there is a need to examine the molecular dynamics of LDs at the subcellular level. Two-color Infrared

In small molecule organic chemistry the heuristic insight into ring-forming processes that was enabled by Baldwin’s rules some 50 years ago proved a step-change in the role of mechanistically guided synthesis. It created a lens upon and marker of fundamental stereoelectronic and conformation-guided chemical processes. However, despite the widespread role of stereoelectronics and conformational control

Core-shell MOF@COF hybrids were synthesized via subsequent modification of MOF UiO-66-NH2 with 1,3,5-triformylphloroglucinol (TFP) and 2,3,5,6-tetraaminobenzoquinone (TABQ). The hybrids exhibited significant surface area (236m2/g) and outstanding electrochemical performance (103F/g at 0.5A/g), surpassing both COFs and MOFs, thereby showcasing the potential of on-surface condensation reactions for developing

Functional fluorophores represent an emerging research field, distinguished by their diverse applications, especially in sensing and cellular imaging. After the discovery of Quinine sulfate and subsequent elucidation of the fluorescence mechanism by Sir George Stokes, research in the field of fluorescence gained momentum. Over the past few decades, advancements in sophisticated instruments, including

Different combinations of organomagnesium reagents and zinc bromide react with either 1,3-dimethoxy-4-tert-butylcalix[4]areneH2 (L(OMe)2H2) or trialkoxycalix[4]arenes (L(OR)3H) (R = n-Pr, n-pentyl) to afford mixed-metal calix[4]arene systems. Intruiging molecular structures are formed and the systems are capable of the ring opening polymerisation of ε-caprolactone under N2, air, or as melts.