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Blood pressure reduction and all-cause dementia in people with uncontrolled hypertension: an open-label, blinded-endpoint, cluster-randomized trial Nat. Med. (IF 58.7) Pub Date : 2025-04-21 Jiang He, Chuansheng Zhao, Shanshan Zhong, Nanxiang Ouyang, Guozhe Sun, Lixia Qiao, Ruihai Yang, Chunxia Zhao, Huayan Liu, Weiyu Teng, Xu Liu, Chang Wang, Songyue Liu, Chung-Shiuan Chen, Jeff D. Williamson, Yingxian Sun
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The Exploration of Indole-Based LSD1-Targeted Inhibitors for Enhanced Immune Response in Gastric Cancer via the PD-L1/PD-1 Axis J. Med. Chem. (IF 6.8) Pub Date : 2025-04-21 Hang Zhang, Yujie Zhang, Yinping Geng, Xuanlong Zhen, Xiaodi Wang, Qiange Yin, Peng Zhang, Yuanyuan Li, Mengzhen Zhang, Yi-chao Zheng, Bing-rui Liu, Hui-min Liu, Hai-wei Xu
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Discovery and Evaluation of DA-302168S as an Efficacious Oral Small-Molecule Glucagon-Like Peptide-1 Receptor Agonist J. Med. Chem. (IF 6.8) Pub Date : 2025-04-21 Guangxin Dong, Qijun Ye, Wenwen Li, Shaofeng Zhang, Zhenyu Yang, Rui Zhang, Ta Deng, Haiyan Li, Yong Zhang, Xiaojie Zhang, Shucheng He, Daoheng Zhou, Juan Zhang, Peng He, Zhou Yu, Yi Li
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Thienopyrimidinone Derivatives as a GluN2B/C/D Biased, Positive Allosteric Modulator of the N-Methyl-d-Aspartate Receptor J. Med. Chem. (IF 6.8) Pub Date : 2025-04-20 Russell G. Fritzemeier, Nicholas S. Akins, Paul J. Arcoria, Srinu Paladugu, Elijah Z. Ullman, James Allen, Rehan Sheikh, Kelsey A. Nocilla, Ellington D. McDaniels, Emanuel M. Coleman, Pantelis Antonoudiou, Michael P. D’Erasmo, Perry Bartsch, Savita K. Sharma, Jamie Maguire, Stephen F. Traynelis, Dennis C. Liotta
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Terminally Symmetric β-Turn Peptides for Multidrug-Resistant Bacterial Infections J. Med. Chem. (IF 6.8) Pub Date : 2025-04-20 Long Tian, Taoran Wang, Liang Luan, Zhao Meng, Jiaqi Han, Chunhui Zhao, Yijie Xu, Chunlan Zeng, Weifeng Ye, Shuyuan Jiang, Li Zhang, Jiye Yin, Qingbin Meng, Song Li
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Synthetic Flavonoid Dimers: Synthesis Strategies and Biological Activities Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-04-21 Rui Pereira, Daniela Ribeiro, Vera L.M. Silva, Eduarda Fernandes
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ALK-based dual inhibitors: Focus on recent development for non-small cell lung cancer therapy Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-04-17 Qiu-Ge Liu, Ji Wu, Zi-Yue Wang, Bing-Bing Chen, Yi-Fei Du, Jin-Bo Niu, Jian Song, Sai-Yang Zhang
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Targeted vancomycin delivery via in situ albumin conjugation and acid-triggered drug release for reduced nephrotoxicity Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-04-18 Tao Li, Ziyi Tang, Ruixue Zhang, Mahesh Challa, Hongzhi Gong, Zhi Gong, Shao-Lin Zhang, Jian Guo, Yun He
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New drugs approved by the NMPA in 2024: Synthesis and clinical applications Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-04-17 Xinxin Zhao, Lin Yuan, Zheng Gong, Mengqi Li, Ye Yuan, Jin Geng
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Fluorinated sulfonamide-flavonoid derivatives as novel Keap1-Nrf2 inhibitors: Potent induction of cytoprotective gene HO-1 in vivo Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-04-17 Yali Sang, Weifang Huang, Jiacheng Lin, Liu Yang, Yuge Zhou, Chang Yu, Xuehua Sun, Hong Yu, Xiaoni Kong
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Design and Synthesis of Novel Styrylquinolinium Derivatives for the Treatment of Breast Cancer: Targeting the c-Myc G-Quadruplex Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-04-20 Xutong Wang, Yu Liu, Zeyu Gao, Xiaodong Fang, Kejing Ma, Meng Sun, Qiming Li, Bing Wang, Yong Zhang, Xin Zhao, Weina Han
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Discovery of Novel 4-Azaindole Derivatives as Selective Nav1.2 Inhibitor with Potent Antiepileptic Activity and Low Neurotoxicity Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-04-19 Bin Lou, Wenhui Liang, Nan Jiang, Yuhan Guo, Tianhao Zhang, Chuanlong Guo, Tongtong Du, Longjiang Huang, Haibo Yu
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Development of potent inhibitors targeting bacterial prolyl-tRNA synthetase through fluorine scanning-directed activity tuning Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-04-16 Zhiteng Luo, Haipeng Qiu, Xiaoying Peng, Qingyun Tan, Bingyi Chen, Qiong Gu, Hongwei Liu, Huihao Zhou
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ByeTAC: Bypassing E-Ligase-Targeting Chimeras for Direct Proteasome Degradation J. Med. Chem. (IF 6.8) Pub Date : 2025-04-19 Cody A. Loy, Eslam M. H. Ali, Laurence J. Seabrook, Timothy J. Harris, Jr, Kate A. Kragness, Lauren Albrecht, Darci J. Trader
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Discovery of a Potent Ornithine-Modified Gramicidin S Analogue Against Drug-Resistant Staphylococcus aureus and Enterococcus faecalis with Minimal Red Blood Cell Toxicity Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-04-19 Harshita Dubkara, Jhajan Lal, Deepanshi Saxena, Abdul Akhir, Rahul Maitra, Sidharth Chopra, Damodara N. Reddy
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A new short pH-responsive anticancer peptide derived by intramolecular charge shielding strategy Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-04-19 Linlin Chang, Kaixin Ran, Fengzhan Wu, Yali Tian, Yuxia Wang, Linfeng Liu, Xiaoyan Wu, Xu Ouyang, Beibei Li, Zufang Ba, Sanhu Gou, Chao Zhong, Hui Liu, Yun Zhang, Jingman Ni
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Tumor-specific Cathepsin B-triggered fluorescence imaging and prodrug activation Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-04-19 Luyang Wang, Houchi Yang, Wanyun Huang, Guojun Ran, Xiaolong He, Mark Bradley, Shan Qian
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Design, synthesis and biological activity of novel pyrimidine piperazine ureas as μ-opioid and TRPV1 dual-target ligands for pain management Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-04-18 Yusui Wang, Shuyu Liu, Zhikang Zhang, Yunmeng Ma, Kexin Qin, Jiahao Du, Yu Wang, Bingxin Wang, Hai Qian, Xiaobin Pang, Fenqin Zhao, Guanhua Du, Lin Yan
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Enhancing the Activity of γ-Hydroxy Lactone Derivatives as Innovative Peroxisome Proliferator-Activated Receptor γ Non-Agonists Inhibiting Cyclin-Dependent Kinase 5-Mediated Phosphorylation Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-04-18 Giulia Cazzaniga, Davide Capelli, Roberta Montanari, Enrico Mario Alessandro Fassi, Giovanni Grazioso, Andrea Tresoldi, Francesca Rinaldi, Enrica Calleri, Ivan Bassanini, Sergio Romeo, Mariangela Garofalo, Matteo Mori, Fiorella Meneghetti, Stefania Villa
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Challenging Triple Negative Breast Cancer through HDAC6 selective inhibition: novel cap-group identification, structure-activity relationships, computational and biological studies Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-04-18 Simona Barone, Ivana Bello, Anna Guadagni, Carmen Cerchia, Gessica Filocamo, Emilia Cassese, Antonella Ilenia Alfano, Camilla Esposito, Álvaro Javier Feliz Morel, Mirko Brunetti, Antonio Lavecchia, Vincenzo Summa, Elisabetta Panza, Margherita Brindisi
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Discovery of a novel molecular glue degrader targeting GSPT1/2 with a non-IMiD-based CRBN binder Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-04-15 Seulki Park, Akshay D. Takwale, Ji-Eun Lee, Namsik Yu, Yong Hyo Kim, Joo Youn Lee, Yong Hee Cho, Jin Hwa Cho, Jeong Hee Moon, Gaseul Lee, Jung-Ae Kim, Jong Yeon Hwang, Jeong-Hoon Kim
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Challenging the “Undruggable”─Targeting STAT3 but Identifying Potent TrkA-Targeted Inhibitors J. Med. Chem. (IF 6.8) Pub Date : 2025-04-17 Petar Iliev, Conall McCutcheon, Tizita H. Admas, Anja Reithmeier, Melanie Lopez McDonald, Alexandre van Outryve, Danielle Hanke, Jennifer I. Brown, Martin Haraldsson, Robert-Alain Toillon, David A. Frank, Brent D. G. Page
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Helmholtz Health task force to strengthen prevention research and its translation globally Nat. Med. (IF 58.7) Pub Date : 2025-04-18
Prevention research aims to understand, mitigate and ultimately avert the onset and progression of disease and the spillover of pathogens. Such research includes the analysis of risk factors and fundamental mechanisms of disease emergence, early detection and screening, stratification into risk groups, and the development and evaluation of preventive interventions. In the face of population aging and
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Association between plausible genetic factors and weight loss from GLP1-RA and bariatric surgery Nat. Med. (IF 58.7) Pub Date : 2025-04-18 Jakob German, Mattia Cordioli, Veronica Tozzo, Sarah Urbut, Kadri Arumäe, Roelof A. J. Smit, Jiwoo Lee, Josephine H. Li, Adrian Janucik, Yi Ding, Akintunde Akinkuolie, Henrike O. Heyne, Andrea Eoli, Chadi Saad, Yasser Al-Sarraj, Rania Abdel-latif, Shaban Mohammed, Moza Al Hail, Alexandra Barry, Zhe Wang, Tatiana Cajuso, Andrea Corbetta, Pradeep Natarajan, Samuli Ripatti, Anthony Philippakis, Lukasz
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BCMA-CAR T-cells in a patient with relapsing idiopathic inflammatory myositis after CD19-CAR T-cells Nat. Med. (IF 58.7) Pub Date : 2025-04-17 Fabian Müller, Andreas Wirsching, Melanie Hagen, Simon Völkl, Carlo Tur, Maria Gabriella Raimondo, Jule Taubmann, Laura Bucci, Liang Zhang, Sascha Kretschmann, Michael Aigner, Markus Eckstein, Silvia Spörl, Soraya Kharboutli, Sebastian Böltz, Armin Atzinger, Luis Munoz, Georg Schett, Andreas Mackensen, Ricardo Grieshaber-Bouyer
CD19 chimeric antigen receptor (CD19-CAR) T-cell therapy has been shown to induce stable drug-free remission in patients with refractory autoimmune disease. The management of potential relapses is currently unclear. Here, we report on a 45-year-old woman with treatment-refractory Jo-1-associated anti-synthetase syndrome, who initially achieved disease remission after CD19-CAR T-cell therapy but then
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Structure Optimization of Natural Product Piperine to Obtain Novel and Potent Analogs with Anti-inflammation Pain and Urate-Lowering Effect Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-04-17 Chunxia Liu, Wenxin Wang, Ruoyang Miao, Haoyang Chen, Ning Wang, Weiyan Cheng, Fengxin Zheng, Zheng Li, Jianxin Pang, Hai Qian, Xin Tian
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Acyclic purine and pyrimidine nucleotide analogs as ecto-5’-nucleotidase (CD73) inhibitors Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-04-17 Stephanie Federico, Christian Renn, Petra Brehova, Zlatko Janeba, Susanne Moschütz, Katharina Sylvester, Rasha Abu Shamleh, Helay Baburi, Herbert Zimmermann, Ali El-Tayeb, Norbert Sträter, Christa E. Müller
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Design and synthesis of pyridine-based benzamides as potent HDAC3 inhibitors as an armament against breast cancer with in vivo validation Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-04-17 Ambati Himaja, Ganesh Routholla, Tarun Patel, Suvankar Banerjee, Darakhshan Begum, Sanjeev Regula, Sravani Pulya, Swati Biswas, Nilanjan Adhikari, Balaram Ghosh
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N,N’-bridged heterocyclic bis-iminium salts as potent antimalarial agents against multi-resistant Plasmodium falciparum Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-04-17 M.C. Casanova, Y. Zhao, S. Hutter, M. Fil, M.H. Do, A. Benech, T.-B. Muller, C. Curti, M. Médebielle, P. Vanelle, N. Azas, J. Broggi
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Discovery of fluorescent and theranostic probes for glycogen synthase kinase-3β in living cells and brain tissues: Detection and imaging in models of Alzheimer's disease Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-04-17 Yu Chen, Hanyue Dong, Xiaoling Huang, Lulu Jiang, Zixing Jiang, Lanqing Li, Jinhui Hu, Wen-Hua Chen
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Linker and Head-Group Exploration of Anti-MRSA Triaromatic Pleuromutilins J. Med. Chem. (IF 6.8) Pub Date : 2025-04-17 Christoffer V. Heidtmann, Christian Ding Fisker, Sarah Løgstrup, Patrick G. Eriksen, Louise H. Storm, Kristian Stærk, Laust Moesgaard, Maria Pedersen, Martin J. Madsen, Ahmed Yusuf, Krista Urup, Iben S. Højgaard, Jayappragash Ramesh, Rasmus H. Pihlsbech, Caroline B. Sørensen, Tore L. Rønn, Alexander B. Larsen, Laurits R. Caspersen, Mathias Æ. Møller, Chris R. Sixhøj, Niels Frimodt-Møller, Janne K.
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Structure-Guided Design of ISOX-DUAL-Based Degraders Targeting BRD4 and CBP/EP300: A Case of Degrader Collapse J. Med. Chem. (IF 6.8) Pub Date : 2025-04-17 Anthony K. Edmonds, Dimitrios-Ilias Balourdas, Graham P. Marsh, Robert Felix, Bradley Brasher, Jeff Cooper, Cari Graber-Feesl, Madhu Kollareddy, Karim Malik, Helen Stewart, Timothy J. T. Chevassut, Ella Lineham, Simon Morley, Oleg Fedorov, James Bennett, Mohan B. Rajasekaran, Samuel Ojeda, Drew A. Harrison, Christopher J. Ott, Andreas C. Joerger, Hannah J. Maple, John Spencer
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A Novel Compound 3a-M1, from Metabolites of Sinomenine Derivative 3a, Exerts Potent Anti-Aplastic Anemia Activity via IP3R/ORAI-Mediated CTL Ferroptosis J. Med. Chem. (IF 6.8) Pub Date : 2025-04-17 Ziqian Zhang, Xilan Ma, Wei Pan, Xiaoshun Li, Yanyan Li, Nan Fang, Xin Yin, Longlong Yang, Qi Hou, Dezhi Yang, Tengfei Ji, Ruifang Zheng, Mingbao Lin
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Discovery and Evaluation of Active Site-Directed, Potent, and Selective Sulfophenyl Acetic Amide-Based Inhibitors for the Laforin Phosphatase J. Med. Chem. (IF 6.8) Pub Date : 2025-04-16 Jianping Lin, Rongjun He, Zihan Qu, Jiajun Dong, Aaron D. Krabill, Li Wu, Yunpeng Bai, Lindsey R. Conroy, Ronald C. Bruntz, Yiming Miao, Brenson A. Jassim, Benjamin Babalola, Frederick Georges Bernard Nguele Meke, Ramon Sun, Matthew S. Gentry, Zhong-Yin Zhang
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Discovery and Optimization of Potent and Highly Selective PARP14 Inhibitors for the Treatment of Atopic Dermatitis J. Med. Chem. (IF 6.8) Pub Date : 2025-04-16 Shiqi Wu, Xiaorong Zeng, Jing Liu, Kaiyuan Cong, Shaoxue Lou, Ziyue Li, Ping Wei, Li Shao, Yaoyao Zhang, Le Qu, Tizhi Wu, Hongfeng Gu, Yan Zhao, Zhaoxing Chu, Qihua Zhu, Guangwei He, Yi Zou, Yungen Xu
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Using AI to screen for opioid use disorder Nat. Med. (IF 58.7) Pub Date : 2025-04-17 Louisa Picco, Suzanne Nielsen
An AI-driven screener for opioid use disorder in hospital settings could increase referrals to addiction services and improve patient outcomes, but it is crucial that treatment is accessible and that unintended harms such as stigma are avoided.
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Anti-amyloid could help prevent genetic form of Alzheimer’s disease Nat. Med. (IF 58.7) Pub Date : 2025-04-17
Despite a negative primary outcome, a trial of gantenerumab showed a clinically meaningful slowing of disease onset in asymptomatic people who were treated for the longest duration.
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Benzothiazole Amide Analogues as Antagonists of TRPC 6 Channels: A Therapeutic Approach for Kidney Fibrosis Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-04-17 Chunlin Ren, Qiding Xu, Qiusi Luo, Xue Qiao, Taotao Ding, Wumei Wang, Xiaodong Zeng, Cheng Chen, Yuling Xiao, Xuechuan Hong
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Scaffold Hopping-Based Structural Modification of Tranilast Led to the Identification of HNW005 as a Promising NLRP3 Inflammasome and URAT1 Dual Inhibitor for the Treatment of Gouty Arthritis Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-04-17 Ming Sun, Fengwei Lin, Chenchen Yue, Zijie Wei, Chang Liu, Dan Liu, Xing Chen, Qi Li, Ziyuan Liu, Jihong Han, Zichen Cui, Qing Mao, Xinyu Li, Peng Zhang, Bing Zhang, Xuefeng Fu, Han Wang, Yanhua Mou, Shaojie Wang
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Anticancer Potential of Synthetic Costunolide and Dehydrocostus Lactone Derivatives: A Systematic Review Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-04-16 Mumen F.A. Amer, Dima Hattab, Athirah Bakhtiar
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The aryl hydrocarbon receptor: a rehabilitated target for therapeutic immune modulation Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-04-17 Carolina M. Polonio, Kimberly A. McHale, David H. Sherr, David Rubenstein, Francisco J. Quintana
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Back to the drawing board for anhedonia drugs Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-04-16
Johnson & Johnson has discontinued development of aticaprant for depression with anhedonia, a blow to hopes for drugs for ‘domains’ of psychiatric disorders.
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Author Correction: Mpox poses an ever-increasing epidemic and pandemic risk Nat. Med. (IF 58.7) Pub Date : 2025-04-16 Carlos Maluquer de Motes, David O. Ulaeto
Correction to: Nature Medicine https://doi.org/10.1038/s41591-025-03589-8, published online 1 April 2025.
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Ubiquitin-Specific Protease 7 (USP7) as a Promising Therapeutic Target for Drug Discovery: From Mechanisms to Therapies J. Med. Chem. (IF 6.8) Pub Date : 2025-04-16 Yihui Song, Xiangli Ren, Jinbo Xiong, Wenwen Wang, Qianyan Zhao, Junbiao Chang, Bin Yu
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Identification of JNJ-61803534, a RORγt Inverse Agonist for the Treatment of Psoriasis J. Med. Chem. (IF 6.8) Pub Date : 2025-04-16 Olaf Kinzel, Steven D. Goldberg, Maxwell D. Cummings, Christian Gege, Christoph Steeneck, Xiaohua Xue, Michael Albers, Thomas Schlüter, Gerald Kleymann, Brian Scott, Kia Sepassi, Freddy Schoetens, Hariharan Venkatesan, Virginia M. Tanis, Kevin Coe, Zachary S. Sales, John Spurlino, Cynthia Milligan, Anne M. Fourie, James P. Edwards, Thomas Hoffmann
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Structure-Guided Design of Pyrazolopyrimidinones as Highly Potent and Selective Allosteric SHP2 Inhibitors J. Med. Chem. (IF 6.8) Pub Date : 2025-04-16 Yihui Song, Xiangli Ren, Xinyu Yang, Jinbo Xiong, Wenwen Wang, Kai Tang, Bin Yu
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Shooting an Arrow against Convulsion: Novel Triazole-Grafted Benzenesulfonamide Derivatives as Carbonic Anhydrase II and VII Inhibitors J. Med. Chem. (IF 6.8) Pub Date : 2025-04-16 Mohamed A. Zeidan, Mahmoud Abdelrahman Alkabbani, Simone Giovannuzzi, Eman F. Khaleel, Anwar A. El-Hamaky, Nourhan A. Khattab, Rehab Badi, Abdelhameed Abubakr, Abdallah M. Hamdy, Mohamed Fares, Haytham O. Tawfik, Claudiu T. Supuran, Wagdy M. Eldehna, Moataz A. Shaldam
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The Prosperity and Adversity of M4 Muscarinic Acetylcholine Receptor Activators in the Treatment of Neuropsychiatric Disorders J. Med. Chem. (IF 6.8) Pub Date : 2025-04-16 Boqun Liu, Arthur Christopoulos, David M. Thal, Ben Capuano, Celine Valant, Peter J. Scammells
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A Comprehensive Review of Small Molecules, Targets, and Pathways in Ulcerative Colitis Treatment Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-04-15 Xiao-Xuan Cai, Yi-Han Huang, Yang-Chi-Dung Lin, Hsi-yuan Huang, Yi-Gang Chen, Da-Peng Zhang, Tao Zhang, Yue Liu, Hua-Li Zuo, Hsien-Da Huang
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Back to therapeutic modality basics Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-04-16
Andy Plump, Takeda’s head of R&D, discusses the company’s evolving pipeline, therapeutic modalities, and upheaval in biotech, the NIH and the FDA.
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Author Correction: The type II RAF inhibitor tovorafenib in relapsed/refractory pediatric low-grade glioma: the phase 2 FIREFLY-1 trial Nat. Med. (IF 58.7) Pub Date : 2025-04-16 Lindsay B. Kilburn, Dong-Anh Khuong-Quang, Jordan R. Hansford, Daniel Landi, Jasper van der Lugt, Sarah E. S. Leary, Pablo Hernáiz Driever, Simon Bailey, Sébastien Perreault, Geoffrey McCowage, Angela J. Waanders, David S. Ziegler, Olaf Witt, Patricia A. Baxter, Hyoung Jin Kang, Timothy E. Hassall, Jung Woo Han, Darren Hargrave, Andrea T. Franson, Michal Yalon Oren, Helen Toledano, Valérie Larouche
Correction to: Nature Medicine https://doi.org/10.1038/s41591-023-02668-y, published online 17 November 2023.
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Meta-prediction of coronary artery disease risk Nat. Med. (IF 58.7) Pub Date : 2025-04-16 Shang-Fu Chen, Sang Eun Lee, Hossein Javedani Sadaei, Jun-Bean Park, Ahmed Khattab, Jei-Fu Chen, Corneliu Henegar, Nathan E. Wineinger, Evan D. Muse, Ali Torkamani
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Publisher Correction: Neoantigen-specific tumor-infiltrating lymphocytes in gastrointestinal cancers: a phase 2 trial Nat. Med. (IF 58.7) Pub Date : 2025-04-15 Frank J. Lowery, Stephanie L. Goff, Billel Gasmi, Maria R. Parkhurst, Nivedita M. Ratnam, Hyunmi K. Halas, Thomas E. Shelton, Michelle M. Langhan, Aarushi Bhasin, Aaron J. Dinerman, Victoria Dulemba, Ian S. Goldlust, Alexandra M. Gustafson, Abraham A. Hakim, Kyle J. Hitscherich, Lisa M. Kenney, Lior Levy, Juliette G. Rault-Wang, Alakesh Bera, Satyajit Ray, Courtney D. Seavey, Chuong D. Hoang, Jonathan
Correction to: Nature Medicine https://doi.org/10.1038/s41591-025-03627-5, published online 1 April 2025.
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Can AI-powered brain–computer interfaces boost human intelligence? Nat. Med. (IF 58.7) Pub Date : 2025-04-15
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Author Correction: LILRB3 genetic variation is associated with kidney transplant failure in African American recipients Nat. Med. (IF 58.7) Pub Date : 2025-04-15 Zeguo Sun, Zhengzi Yi, Chengguo Wei, Wenlin Wang, Tianyuan Ren, Paolo Cravedi, Fasika Tedla, Stephen C. Ward, Evren Azeloglu, Daniel R. Schrider, Yun Li, Atlas Khan, Francesca Zanoni, Jia Fu, Sumaria Ali, Shun Liu, Deguang Liang, Tong Liu, Hong Li, Caixia Xi, Thi Ha Vy, Gohar Mosoyan, Quan Sun, Ashwani Kumar, Zhongyang Zhang, Samira Farouk, Kirk Campell, Jordi Ochando, Kyung Lee, Steve Coca, Jenny
Correction to: Nature Medicine https://doi.org/10.1038/s41591-025-03568-z, published online 10 March 2025.
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Reprogramming the tumor immune microenvironment to treat glioblastoma Nat. Med. (IF 58.7) Pub Date : 2025-04-15
Johanna Joyce describes how disrupting tumor-associated macrophages showed the importance of the tumor microenvironment in treating cancer.
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Discovery of Dual PD-L1/HDAC3 Inhibitors for Tumor Immunotherapy J. Med. Chem. (IF 6.8) Pub Date : 2025-04-15 Zhijie Wang, HaiQi He, Xiaotong Liao, Lin Yuan, Shuding Sun, Chenglong Xu, Xixiang Yang, Qinru Zang, Xiaopeng Peng, Jianjun Chen, Xia Guo
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Discovery of Novel SHP2 ATTEC Degraders against Pancreatic Ductal Adenocarcinoma Harboring KRAS(G12D) Mutations J. Med. Chem. (IF 6.8) Pub Date : 2025-04-15 Yue Zhong, Yan Lu, Jiahui Li, Qiang Ren, Yiqing Fan, Xiqi Meng, Jieyu Shao, Hai Qian
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