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Discovery of Novel Non-nucleoside DOT1LR231Q Inhibitors with Improved Pharmacokinetic Properties and Anti-lung Cancer Efficacy J. Med. Chem. (IF 6.8) Pub Date : 2024-09-10 Zehui Tan, Ning Guo, Shuyu Liu, Jiandong Li, Yu Chen, Jianming Cui, Hongrui Lei, Nan Jiang, Lihui Wang, Xin Zhai
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Structure–Activity Relationship of Inositol Thiophosphate Analogs as Allosteric Activators of Clostridioides difficile Toxin B J. Med. Chem. (IF 6.8) Pub Date : 2024-09-10 Rebecca Cummer, Félix Grosjean, Raphaël Bolteau, Seyed Ehsan Vasegh, Simon Veyron, Liam Keogh, Jean-François Trempe, Bastien Castagner
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Influence of Trp-Cage on the Function and Stability of GLP-1R Agonist Exenatide Derivatives J. Med. Chem. (IF 6.8) Pub Date : 2024-09-10 Dániel Horváth, Pál Stráner, Nóra Taricska, Zsolt Fazekas, Dóra K. Menyhárd, András Perczel
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Identifying Artifacts from Large Library Docking J. Med. Chem. (IF 6.8) Pub Date : 2024-09-10 Yujin Wu, Fangyu Liu, Isabella Glenn, Karla Fonseca-Valencia, Lu Paris, Yuyue Xiong, Steven V. Jerome, Charles L. Brooks, III, Brian K. Shoichet
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Can Machine Learning Overcome the 95% Failure Rate and Reality that Only 30% of Approved Cancer Drugs Meaningfully Extend Patient Survival? J. Med. Chem. (IF 6.8) Pub Date : 2024-09-10 Duxin Sun, Christian Macedonia, Zhigang Chen, Sriram Chandrasekaran, Kayvan Najarian, Simon Zhou, Tim Cernak, Vicki L. Ellingrod, H. V. Jagadish, Bernard Marini, Manjunath Pai, Angela Violi, Jason C. Rech, Shaomeng Wang, Yan Li, Brian Athey, Gilbert S. Omenn
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A Lysosome-Targeting hNEU1 Inhibitor Treats Myocardial Infarction: A Potential Therapeutic Breakthrough J. Med. Chem. (IF 6.8) Pub Date : 2024-09-10 Wen Zhou, Wanxiang Yang, Ping Jiang, Shaohua Gou
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Upcoming market catalysts in Q4 2024 Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2024-09-10
Discover the world’s best science and medicine | Nature.com
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Structure, Function, and Activity of Small Molecule and Peptide Inhibitors of Protein Arginine Methyltransferase 1 J. Med. Chem. (IF 6.8) Pub Date : 2024-09-09 Thordur Hendrickson-Rebizant, Sadhana R. N. Sudhakar, Michael J. Rowley, Adam Frankel, James R. Davie, Ted M. Lakowski
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The “Doorstop Pocket” In Thioredoxin Reductases─An Unexpected Druggable Regulator of the Catalytic Machinery J. Med. Chem. (IF 6.8) Pub Date : 2024-09-09 Matteo Ardini, Sammy Y. Aboagye, Valentina Z. Petukhova, Irida Kastrati, Rodolfo Ippoliti, Gregory R. J. Thatcher, Pavel A. Petukhov, David L. Williams, Francesco Angelucci
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Photoinduction of Ferroptosis and cGAS-STING Activation by a H2S-Responsive Iridium(III) Complex for Cancer-Specific Therapy J. Med. Chem. (IF 6.8) Pub Date : 2024-09-09 Yi Li, Ben Liu, Yue Zheng, Meng Hu, Liu-Yi Liu, Cai-Rong Li, Wei Zhang, Yu-Xiao Lai, Zong-Wan Mao
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Discovery of Thiophene Derivatives as Potent, Orally Bioavailable, and Blood–Brain Barrier-Permeable Ebola Virus Entry Inhibitors J. Med. Chem. (IF 6.8) Pub Date : 2024-09-09 Marcos Morales-Tenorio, Fátima Lasala, Alfonso Garcia-Rubia, Elnaz Aledavood, Michelle Heung, Catherine Olal, Beatriz Escudero-Pérez, Covadonga Alonso, Ana Martínez, César Muñoz-Fontela, Rafael Delgado, Carmen Gil
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Neurons give metastatic cells a push Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2024-09-09
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Splice-switching ASO curtails brain calcification Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2024-09-09
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PPAR agonists provide new treatment options for inflammatory liver disease Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2024-09-09
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RIPTACs expand anticancer target space Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2024-09-09
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Organoids identify a role for IL-7 in coeliac disease Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2024-09-09
Discover the world’s best science and medicine | Nature.com
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Prenatal exposure to famine affects lifelong health Nat. Med. (IF 58.7) Pub Date : 2024-09-09
Analysis of data related to the Ukraine famine of 1932–1933 shows that in utero exposure to famine increases the risk of adult type 2 diabetes by more than twofold.
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Merging Natural Product Structures with Pharmaceutical Leads: Unnatural Enantiomers of Estranes as Glucocorticoid Receptor Modulators That Suppress TNF-α and IL-6 Release J. Med. Chem. (IF 6.8) Pub Date : 2024-09-06 Joshua M. Nicholson, Dexi Yang, Thomas Koelblen, Eric L. Hu, Christopher C. Coss, Thomas P. Burris, Xiao Hu, Glenn C. Micalizio
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A Photoactivatable Version of Ivabradine Enables Light-Induced Block of HCN Current In Vivo J. Med. Chem. (IF 6.8) Pub Date : 2024-09-05 Alessandro Porro, Edoardo Armano, Federico Brandalise, Rebecca Appiani, Monica Beltrame, Andrea Saponaro, Clelia Dallanoce, Koichi Nakajo, Kaei Ryu, Roberta Leone, Gerhard Thiel, Marco Pallavicini, Anna Moroni, Cristiano Bolchi
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Developing a Palladium(II) Agent to Overcome Multidrug Resistance and Metastasis of Liver Tumor by Targeted Multiacting on Tumor Cell, Inactivating Cancer-Associated Fibroblast and Activating Immune Response J. Med. Chem. (IF 6.8) Pub Date : 2024-09-05 Ming Jiang, Wenjuan Li, Jinzhe Liang, Min Pang, Shanhe Li, Gang Xu, Minghui Zhu, Hong Liang, Zhenlei Zhang, Feng Yang
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Development of Tailless Homologue Receptor (TLX) Agonist Chemical Tools J. Med. Chem. (IF 6.8) Pub Date : 2024-09-05 Emily C. Hank, Minh Sai, Till Kasch, Isabelle Meijer, Julian A. Marschner, Daniel Merk
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Structure Tailoring of Hemicyanine Dyes for In Vivo Shortwave Infrared Imaging J. Med. Chem. (IF 6.8) Pub Date : 2024-09-05 Jiaming Guo, Yiling Zhu, Yuqian Qu, Longfei Zhang, Mingxi Fang, Zihan Xu, Tianbao Wang, Yufei Qin, Yihan Xu, Yuying Li, Yimin Chen, Hualong Fu, Xiayu Liu, Yajun Liu, Cheng Liu, Yuan Gao, Mengchao Cui, Kaixiang Zhou
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Antimicrobial Resistance: An Ultimate Challenge for 21st Century Scientists, Healthcare Professionals, and Policymakers to Save Future Generations J. Med. Chem. (IF 6.8) Pub Date : 2024-09-05 Vazahyil Hari Krishnaprasad, Sanjay Kumar
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Natural Product-Inspired Discovery of Naphthoquinone-Furo-Piperidine Derivatives as Novel STAT3 Inhibitors for the Treatment of Triple-Negative Breast Cancer J. Med. Chem. (IF 6.8) Pub Date : 2024-09-03 Chengcheng Fan, Shengying Lou, Chenjun Shen, Jialing Liao, Hao Ni, Siyu Chen, Zhihui Zhu, Xueping Hu, Wei Xie, Huajun Zhao, Sunliang Cui
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Understanding anellovirus immune evasion Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2024-09-06
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Apolipoprotein L2 inhibitor mitigates fibrosis Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2024-09-06
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Targeting the peripheral neural-tumour microenvironment for cancer therapy Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2024-09-06 Dan Yaniv, Brandi Mattson, Sebastien Talbot, Frederico O. Gleber-Netto, Moran Amit
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Cardiovascular safety of vitamin B3 administration Nat. Med. (IF 58.7) Pub Date : 2024-09-05 Stefan Schreiber, Georg H. Waetzig, Matthias Laudes, Philip Rosenstiel
arising from M. Ferrell et al. Nature Medicine https://doi.org/10.1038/s41591-023-02793-8 (2024) Ferrell et al.1 recently reported associations between serum levels of the terminal niacin metabolites N1-methyl-2-pyridone-5-carboxamide (2PY) and N1-methyl-4-pyridone-3-carboxamide (4PY) with an increased 3-year incident risk of major adverse cardiovascular events. The association of 4PY with cardiovascular
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Reply to Guyton, J. R. & Boden, W. E.; Schreiber, S. et al. Nat. Med. (IF 58.7) Pub Date : 2024-09-05 W. H. Wilson Tang, Joseph A. DiDonato, Hooman Allayee, Stanley L. Hazen
replying to J. R. Guyton & W. E. Boden Nature Medicine https://doi.org/10.1038/s41591-024-03220-2 (2024) replying to S. Schreiber et al. Nature Medicine https://doi.org/10.1038/s41591-024-03219-9 (2024)
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Medicine’s DEI backlash offers an opportunity to refocus on evidence-based approaches Nat. Med. (IF 58.7) Pub Date : 2024-09-05 Simar S. Bajaj, Ahmed M. Ahmed, Valerie E. Stone
Diversity, equity and inclusion (DEI) has become a political lightning rod in the USA, with its laudable mission increasingly misinterpreted as a blunt discriminatory tool. Although such critique has been ongoing for decades, it has intensified in academic medicine in recent months, from the resignation of Johns Hopkins’ chief diversity officer over an email on privilege, to efforts within the American
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A global metric of immune health Nat. Med. (IF 58.7) Pub Date : 2024-09-05 Carola G. Vinuesa, Yuke He, Matthew C. Cook
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Niacin, food intake and cardiovascular effects Nat. Med. (IF 58.7) Pub Date : 2024-09-05 John R. Guyton, William E. Boden
arising from M. Ferrell et al. Nature Medicine https://doi.org/10.1038/s41591-023-02793-8 (2024) Ferrell et al.1 report a surprisingly strong association between terminal metabolites of niacin and major adverse cardiovascular events (MACE), amounting to roughly a doubling of MACE risk in the 4th quartile of circulating levels of the 4PY (N1-methyl-4-pyridone-3-carboxamide) metabolite. The results presented
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Opportunities and challenges for patient-reported outcome assessment in multimorbidity research and practice Nat. Med. (IF 58.7) Pub Date : 2024-09-05 Sarah E. Hughes, Nicola E. Anderson, Eleanor Hathaway, Christel McMullan, Benjamin M. A. Hughes, Philip Collis, John Devin Peipert, Shamil Haroon, Melanie Calvert
Multimorbidity, the cooccurrence of two or more chronic health conditions within the same individual, is increasingly prevalent worldwide and is associated with decreased health-related quality of life, increased mortality, and greater healthcare utilization1,2. The clinical care of multimorbidity is complex, arising from potential interactions between conditions, treatment regimens and overlapping
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Tricyclic Benzo[1,3]oxazinyloxazolidinones as Potent Antibacterial Agents against Drug-Resistant Pathogens J. Med. Chem. (IF 6.8) Pub Date : 2024-09-05 Haijia Lu, Xiaowan Han, Di Qin, Li Sheng, Chen Du, Bin Wang, Hongyi Zhao, Yu Lu, Yishuang Liu, Hai-Yu Hu, Ya Liu, Dongfeng Zhang
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Discovery and Evaluation of TLR-Targeted Immune Agonists J. Med. Chem. (IF 6.8) Pub Date : 2024-09-05 Natalia Chernyak, Bhagyashree Bhagwat, Saraswathi Naravula, Ying Chen, Nicolas Solban, Fan Zhang, Esther Kofman, Fahimeh Raoufi, Xibei Dang, Jianming Bao, Daniela Tomazela, Marc Baily, Bernhard Geierstanger, John A. Flygare, Jin-Hwan Han, Aarron Willingham, W. Michael Seganish
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Transferrin-Modified Carprofen Platinum(IV) Nanoparticles as Antimetastasis Agents with Tumor Targeting, Inflammation Inhibition, Epithelial–Mesenchymal Transition Suppression, and Immune Activation Properties J. Med. Chem. (IF 6.8) Pub Date : 2024-09-05 Ming Zhang, Yan Chen, Shuaiqi Feng, Yanqin He, Zhifang Liu, Ning Zhang, Qingpeng Wang
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Structure Activity of β-Amidomethyl Vinyl Sulfones as Covalent Inhibitors of Chikungunya nsP2 Cysteine Protease with Antialphavirus Activity J. Med. Chem. (IF 6.8) Pub Date : 2024-09-05 Anirban Ghoshal, Kesatebrhan Haile Asressu, Mohammad Anwar Hossain, Peter J. Brown, Meganathan Nandakumar, Anand Vala, Eric M. Merten, John D. Sears, Isabella Law, Jane E. Burdick, Noah L. Morales, Sumera Perveen, Kenneth H. Pearce, Konstantin I. Popov, Nathaniel J. Moorman, Mark T. Heise, Timothy M. Willson
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Photostable Iridium(III) Cyclometallated Complex is an Efficient Photosensitizer for Killing Multiple Cancer Cell Lines and 3D Models under Low Doses of Visible Light J. Med. Chem. (IF 6.8) Pub Date : 2024-09-04 Callum Jones, Marta Martinez-Alonso, Hannah Gagg, Liam Kirby, Julia A. Weinstein, Helen E. Bryant
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The New Frontier: Merging Molecular Glue Degrader and Antibody–Drug Conjugate Modalities To Overcome Strategic Challenges J. Med. Chem. (IF 6.8) Pub Date : 2024-09-04 Yam B. Poudel, Ruchita R. Thakore, Eugene P. Chekler
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Discovery of a Highly Potent and Selective Inhibitor Targeting Protein Lysine Methyltransferase NSD2 J. Med. Chem. (IF 6.8) Pub Date : 2024-09-04 Jianwei Wei, Qiongyu Shi, Bang Li, Hong Yang, Li Liu, Ruilin Zhou, Zongbo Feng, Zhenjiao Yang, Jinhong Zhan, Xiao-Feng Xiong, Xun Huang, Yuanxiang Wang
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A Glycyrrhizin Derivative with a More Potent Inhibitory Activity against High-Mobility Group Box 1 Efficiently Discovered by Chemical Synthesis Inspired by the Bioconversion Products of an Endophytic Fungus Isolated from Licorice J. Med. Chem. (IF 6.8) Pub Date : 2024-09-04 Aoi Machida, Kengo Banshoya, Akiho Miyamaru, Tamaki Eto, Shoji Maehara, Yuhzo Hieda, Toshiyuki Hata, Masatoshi Ohnishi
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Re-Evaluating PIN1 as a Therapeutic Target in Oncology Using Neutral Inhibitors and PROTACs J. Med. Chem. (IF 6.8) Pub Date : 2024-09-04 Chuan Liu, Zhonghui Chen, Tao Chen, Hongmei Song, Jianbo Shen, Xiaoxi Yuan, Shuai Xia, Qian Liu, Qiuxia Chen, Qiang Tian, Xiaoyun Meng, Zhu Han, Xiaofei Dong, Yu Yang, Longying Cai, Xuemin Cheng, Yangyang Jia, Guansai Liu, Jin Li, Junyou Ge, Dengfeng Dou
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Heat Shock Protein 90 Interactome-Mediated Proteolysis Targeting Chimera (HIM-PROTAC) Degrading Glutathione Peroxidase 4 to Trigger Ferroptosis J. Med. Chem. (IF 6.8) Pub Date : 2024-09-04 Jinyun Dong, Furong Ma, Maohua Cai, Fei Cao, Haobin Li, Hui Liang, Yulong Li, Guangyu Ding, Juan Li, Xiangdong Cheng, Jiang-Jiang Qin
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Rational Design, Synthesis, and Structure–Activity Relationship of a Novel Isoquinolinone-Based Series of HBV Capsid Assembly Modulators Leading to the Identification of Clinical Candidate AB-836 J. Med. Chem. (IF 6.8) Pub Date : 2024-09-04 Andrew G. Cole, Steven G. Kultgen, Nagraj Mani, Kristi Yi Fan, Andrzej Ardzinski, Kim Stever, Bruce D. Dorsey, Eugen F. Mesaros, Emily P. Thi, Ingrid Graves, Sunny Tang, Troy O. Harasym, Amy C. H. Lee, Andrea Olland, Robert K. Suto, Michael J. Sofia
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Discovery and Optimization of N-Heteroaryl Indazole LRRK2 Inhibitors J. Med. Chem. (IF 6.8) Pub Date : 2024-09-04 Kaitlyn M. Logan, Will Kaplan, Vladimir Simov, Hua Zhou, Derun Li, Luis Torres, Gregori J. Morriello, John J. Acton, Barbara Pio, Yi-Heng Chen, Mitchell H. Keylor, Rebecca Johnson, Solomon D. Kattar, Ryan Chau, Xin Yan, Michael Ardolino, Cayetana Zarate, Karin M. Otte, Rachel L. Palte, Tina Xiong, Spencer E. McMinn, Shishi Lin, Santhosh F. Neelamkavil, Ping Liu, Jing Su, Laxminarayan G. Hegde, Janice
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A Cyclometalated Iridium(III) Complex Exerts High Anticancer Efficacy via Fatty Acid Beta-Oxidation Inhibition and Sphingolipid Metabolism Reprogramming J. Med. Chem. (IF 6.8) Pub Date : 2024-09-03 Cuiyan Lin, Huiling Wang, Keyu Chen, Shuangqiang Liu, Zhichen Mao, Zuyu Mo, Rizhen Huang, Ye Zhang, Wei Xie, Jianhua Wei, Junfei Jin
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Pyrazolone-Based Zn(II) Complexes Display Antitumor Effects in Mutant p53-Carrying Cancer Cells J. Med. Chem. (IF 6.8) Pub Date : 2024-09-02 Sonila Xhafa, Corrado Di Nicola, Alessia Tombesi, Riccardo Pettinari, Claudio Pettinari, Francesca Scarpelli, Alessandra Crispini, Massimo La Deda, Angela Candreva, Alessia Garufi, Gabriella D’Orazi, Agustín Galindo, Fabio Marchetti
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Protein isoform-centric therapeutics: expanding targets and increasing specificity Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2024-09-04 Peter Kjer-Hansen, Tri Giang Phan, Robert J. Weatheritt
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Hibernation science harnessed to treat obesity and modify metabolism Nat. Med. (IF 58.7) Pub Date : 2024-09-04
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CAR-T and cellular gene therapies are too expensive Nat. Med. (IF 58.7) Pub Date : 2024-09-04 Boro Dropulić
Point-of-care manufacturing and technology transfer can deliver cellular gene therapies at an affordable cost to patients across the world.
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Discovery and optimization of isoliquiritigenin as a death-associated protein kinase 1 inhibitor Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-09-04 Takeshi Yokoyama, Kotono Hisatomi, Saki Oshima, Ichiro Tanaka, Takuya Okada, Naoki Toyooka
Death-associated protein kinase 1 (DAPK1) is a phosphotransferase in the serine/threonine kinase family. Inhibiting DAPK1 is expected to be beneficial in treating Alzheimer's disease and protecting neuronal cells during cerebral ischemia. In this study, we demonstrated that the natural chalcone isoliquiritigenin inhibits DAPK1 in an ATP-competitive manner, and we synthesized halogen derivatives to
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Drug repurposing against antibiotic resistant bacterial pathogens Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-09-04 Manya Aggarwal, Anushree Patra, Ishita Awasthi, Annu George, Simran Gagneja, Varsha Gupta, Neena Capalash, Prince Sharma
The growing prevalence of MDR and XDR bacterial pathogens is posing a critical threat to global health. Traditional antibiotic development paths have encountered significant challenges and are drying up thus necessitating innovative approaches. Drug repurposing, which involves identifying new therapeutic applications for existing drugs, offers a promising alternative to combat resistant pathogens.
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Dual-target inhibitors based on acetylcholinesterase: Novel agents for Alzheimer's disease Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-09-04 Xingyi Zhao, Qiaoguan Hu, Xiaoqian Wang, Chunting Li, Xiao Chen, Dong Zhao, Yue Qiu, Haoyu Xu, Jiaqi Wang, Le Ren, Na Zhang, Shuang Li, Ping Gong, Yunlei Hou
Alzheimer's disease (AD) is the most common form of dementia among the elderly, accounting for 60 %–70 % of cases. At present, the pathogenesis of this condition remains unclear, but the hydrolysis of acetylcholine (ACh) is thought to play a role. Acetylcholinesterase (AChE) can break down ACh transmission from the presynaptic membrane and stop neurotransmitters' excitatory effect on the postsynaptic
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How many organic small molecules might be used to treat COVID-19? From natural products to synthetic agents Eur. J. Med. Chem. (IF 6.0) Pub Date : 2024-09-04 Zai-Qun Liu
A large scale of pandemic coronavirus disease (COVID-19) in the past five years motivates a great deal of endeavors donating to the exploration on therapeutic drugs against COVID-19 as well as other diseases caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Herein is an overview on the organic small molecules that are potentially employed to treat COVID-19 and other SARS-CoV-2-related
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Structural Optimization and Structure–Activity Relationship of 1H-Pyrazole-4-carboxylic Acid Derivatives as DNA 6mA Demethylase ALKBH1 Inhibitors and Their Antigastric Cancer Activity J. Med. Chem. (IF 6.8) Pub Date : 2024-09-03 Feng Li, Liang Xiong, Jian Zhang, Yinping Guo, Ke Xu, Zijie Xiong, Yuyang Wang, Shanmian Ji, Aiping Tong, Linli Li, Shengyong Yang
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The WHO genomics program of work for equitable implementation of human genomics for global health Nat. Med. (IF 58.7) Pub Date : 2024-09-03 Elena Ambrosino, Ahmad N. Abou Tayoun, Marc Abramowicz, Bin Alwi Zilfalil, Tiffany Boughtwood, Yosr Hamdi, Tim Hubbard, Kazuto Kato, Iscia Lopes-Cendes, Partha Pratim Majumder, Deborah Mascalzoni, Rokhaya Ndiaye, Michèle Ramsay, Gabriela M. Repetto, Vorasuk Shotelersuk, Sherry Taylor, John C. Reeder, Anna Laura Ross
The publication of the first draft of the human genome sequence in 20011 was followed by the advent of high-throughput methodologies, which together have driven the expansion of genomic tools and technologies. These efforts have enabled the sequencing of millions of genomes and expedited the functional and clinical annotation of the human genome. The resulting discovery of thousands of gene–disease
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A time-stratified, case–crossover study of heat exposure and perinatal mortality from 16 hospitals in sub-Saharan Africa Nat. Med. (IF 58.7) Pub Date : 2024-09-03 Claudia Hanson, Jeroen de Bont, Kristi Sidney Annerstedt, Maria del Rosario Alsina, Federica Nobile, Nathalie Roos, Peter Waiswa, Andrea Pembe, Jean-Paul Dossou, Effie Chipeta, Lenka Benova, Hussein Kidanto, Cherie Part, Massimo Stafoggia, Veronique Filippi, Petter Ljungman
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A framework for sharing of clinical and genetic data for precision medicine applications Nat. Med. (IF 58.7) Pub Date : 2024-09-03 Ahmed Elhussein, Ulugbek Baymuradov, Noémie Elhadad, Karthik Natarajan, Gamze Gürsoy
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Advancing global antibiotic research, development and access Nat. Med. (IF 58.7) Pub Date : 2024-09-03 Laura J. V. Piddock, Yewande Alimi, James Anderson, Damiano de Felice, Catrin E. Moore, John-Arne Røttingen, Henry Skinner, Peter Beyer
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Integrating liver endpoints in clinical trials of cardiovascular and kidney disease Nat. Med. (IF 58.7) Pub Date : 2024-09-03 Faiez Zannad, Arun J. Sanyal, Javed Butler, Veronica Miller, Stephen A. Harrison
更新日期：2024-09-11
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