Affinity binding-induced DNA assembly is a fundamental principle for designing proximity biosensors for sensitive and wash-free protein detection and imaging. However, current design strategies for these biosensors face an intrinsic trade-off between binding affinity and background signal. Here, we demonstrate that this intrinsic issue can be addressed by using constitutional dynamic chemistry as a

Intrinsically disordered regions (IDRs) are ubiquitous in pro-teins, orchestrating complex cellular signaling through high-er-order protein assemblies. However, the properties and functions of intrinsically disordered peptide (IDP) assemblies are largely underexplored. This work unveiled a facile strategy for engineering IDP assemblies. We demonstrate that conjugating a structured motif derived from

Integrating dissimilar building units of discrete organic cages and inorganic clusters into single-crystal supramolecular frameworks with tailored architectures and synergistic functions presents a significant challenge. Here, we presented our discovery of achieving such hybrids through electrostatically driven self-assembly of cationic ammonium organic cages with anionic lead iodide clusters. Notably

Great achievements have been made in CO2/epoxide copolymerization and dialkyl carbonate/diol polycondensation, however, efficient preparation of high-molecular-weight (> 100 kDa) aliphatic polycarbonates with tunable properties and recyclability under mild conditions still remain as a great challenge. Herein, we presented a “polycondensation−depolymerization−repolymerization” strategy for structurally

Electrochemical nitrate reduction reaction (NO3RR) for ammonia synthesis under acidic conditions offers significant advantages, like direct fertilizer production and prevention of ammonia volatilization. However, three critical challenges persist: instability of metal-based catalysts, competition from the hydrogen evolution reaction (HER), and proton depletion leading to species imbalance. Here, we

The alteration in the coordination environment of metal atoms can manipulate their electronic structure and regulate the electrocatalytic hydrogen evolution activity. In this work, the coordination environment of ruthenium clusters was successfully modulated by introducing the appropriate boron (B) and oxygen (O) elements into the reduced graphene oxide host. The electrochemical tests demonstrate that

Separation of acetylene (C2H2) from carbon dioxide (CO2) remains a challenge to achieve both high C2H2 uptake and selectivity for a single material. Porous materials with routine OMSs often show the limitation in C2H2/CO2 separation due to the comparable binding affinity with the two gases. Herein, we report a new strategy of anchoring highly unsaturated nickel(II) sites into a large-pore MOF (Ni

Integrating water electrolysis (WE) with lithium-mediated nitrogen reduction (Li-NRR) offers a sustainable route for green ammonia production by directly utilizing protons from water oxidation, eliminating reliance on grey or blue hydrogen. Here, polyoxometalates (POMs) function as electron-coupled proton buffers (ECPBs) to seamlessly link WE with Li-NRR in a three-compartment flow reactor comprising

The built-in electric field (BEF) is proposed as a critical design parameter for optimizing small-molecule cathode interlayer materials (SM-CIMs) in organic solar cells (OSCs). By strategically transforming imidazole-functionalized triads from a D-A-D to an A-D-A configuration and replacing the A unit with a more electron-deficient moiety, we developed three triads: (TBT)2NDI, (NDI)2TBT, and (PDI)2TBT

Solar-driven photocatalysis holds promise for fuel production, with halide perovskites leading owing to superior light absorption and carrier diffusion. However, precise control and understanding of interfacial charge separation dynamics in their heterostructures remain challenging. Using formamidinium lead bromide/molybdenum disulfide (FAPbBr3/MoS2) as a model, we engineered Pb-rich, Pb-neutral, and

The global plastic waste crisis, particularly from polyethylene terephthalate (PET), demands sustainable recycling solutions. PET methanolysis offers a promising route to recover high-purity dimethyl terephthalate (DMT), but achieving scalable, cost-effective, and environmentally friendly processes under mild conditions remains challenging. This study introduces a bio-based catalytic system using guaiacol

Strong metal-support interaction (SMSI) plays a crucial role in catalysis, with its encapsulation configuration being highly dependent on the chemical environments. However, the dynamic behavior of SMSI under redox conditions remains insufficiently understood. Here, environmental transmission electron microscopy (ETEM) revealed that SMSI overlayers form stably on the surface of Pd/TiO2 nanocatalysts

A magical heterostructures of M-PBAs (M= Co, Cu, and Zn) encapsulated by V-PBA have been successfully obtained by a facile one-pot coprecipitation method based on the difference in the binding energies of between these metal ions and ligands, and the nucleation rates of different M-PBAs. Hence, due to the multiple redox pairs, open frameworks, ordered channels, and synergistic effect of two components

Chiral organic-inorganic hybrid metal halides (OIHMHs) are commonly constructed by introducing pairs of enantiomorphic chiral precursors through a single chirality transfer pathway, which may limit the regulation of chiral structrual diversity and chiroptoelectronic properties. Herein, we propose a new strategy for achieving reversible chiral induction of OIHMHs with inverted chiroptical properties

Electronic devices often demand high reliability and longevity, but they also contribute significantly to electronic waste. Physically transient electronics have thus emerged as a promising alternative in future electronics, particularly in wearable and implantable bioelectronics. In these applications, memristive materials have gained significant attention for their potential to realize neuromorphic

Transition metal–alkane σ-complexes are key intermediates in C-H activation and, until now, analysis of these species has been restricted to either the solution OR the solid state. Here we present a synthetic methodology that converts Mn2(CO)10 in a non-coordinating solvent environment to [Mn(CO)5]+ at room temperature, and this species binds n-pentane as the strongest interacting ligand available

Ru-based catalysts have exhibited significant promise in converting waste plastics into valuable long-carbon chain products. However, their efficiency is hindered by the uncontrollable cascade hydrogenation, which stems from their exceptional reactivity for C-C cleavage. Herein, we reported a multi-scale regulation strategy by selectively anchoring Fe single atoms (SAs) and FeOx nanoclusters (NCs)

Developing efficient Ru-based catalysts is crucial in reducing reliance on costly Ir for the acidic oxygen evolution reaction (OER). However, these Ru-based catalysts face a fundamental stability challenge due to the highly reactive nature of lattice oxygen. In this work, we propose an effective strategy to stabilize lattice oxygen in two-dimensional amorphous RuOx through p-p orbital hybridization

Nanoscale zero-valent iron (nFe0) materials hold great promise in environmental remediation, yet achieving high reactivity, selectivity, and stability in reduction remains a long-standing challenge. Here, we address this challenge by innovatively employing Ni lattice and FeS surface engineering to fabricate novel nFe0-based nanomaterials (dubbed as FeNix@FeSy), featuring FeNi as the core and FeS as

Integrating electrochemiluminescence (ECL) imaging with a multilevel information encryption strategy overcomes the limitations of conventional encryption methods, which rely solely on abstract electrical signals, by providing intuitive visual outputs. Herein, a dynamic multilevel information encryption system based on ECL imaging was successfully constructed, which realizes robust protection and precisely

This study reports a cobalt-catalyzed enantioselective reductive arylation and alkenylation of sulfinylamines, facilitating the efficient synthesis of enantiopure sulfinamides. By employing a cobalt/chiral diphosphine and tridentate ligand system, a range of diverse aryl and alkenyl iodides were successfully transformed into sulfinamides, achieving high yields and excellent enantioselectivity. This

As one of promising solutions to global warming, electrocatalytic reduction of carbon dioxide (CO2RR) to liquid fuel has attracted great attention. A primary challenges in industrializing CO2RR technologies for producing liquid fuel is the mass transfer limitation of CO2, which significantly reduces the current density of CO2RR. This study proposes a new enzyme-enhanced electrocatalysis platform for

The direct four‐electron oxygen reduction reaction (4e− ORR) critically governs efficiency and lifespan in metal‐air batteries and fuel cells, yet selectively suppressing competitive 2e− and stepwise 2e− pathways that generate corrosive hydrogen peroxide remains a major challenge. Herein, we demonstrate the strategic incorporation of secondary coordinated sulfur atoms into transition metal‐N‐C electrocatalysts

Visible light photoredox catalysis has become a rapidly emerging area owing to its potential of using sunlight to tame previously hard‐to‐harness radicals for organic synthesis. At present, such blueprint faces a significant challenge, namely how to accomplish thermodynamically demanding reactions with sunlight encompassing a wide range of low energy photons. Here, we report a new reaction framework

A metal‐controlled enantiodivergent rearrangement of α‐diazo‐β‐keto oxime ethers has been developed. Switching the metal catalyst from Co(II) to Fe(II) with an identical ligand completely reverses the asymmetric induction. Both enantiomers of chiral 2H‐azirines and its derivatives are accessible under thermal or photolytic conditions. The cobalt‐based reaction is highly efficient even at 0.05 mol%

Targeted protein degradation (TPD) technology holds significant potential for modulating protein homeostasis and treating diseases. However, current methods for degrading membrane protein highly depend on the lysosome‐targeting ligands or membrane receptors. In this study, we present a set of multivalent targeting chimeras (multi‐TACs) for tumor‐specific degradation of programmed death ligand 1 (PD‐L1)

The undesired phase distribution and intrinsic residual lattice strain remain the bottleneck for high‐performance and stable two‐dimensional (2D) or Q‐2D perovskite solar cells (PSCs), especially for the Dion‐Jacobson (DJ) type Q‐2D PSCs. Here, we showcase employing halogen bonds to stabilize the halide anions and fine‐tuning the residual lattice strain by introducing perfluorodecyl iodide (PFI). It

Aliphatic polyesters, such as poly(adipate)esters, are attracting substantial attention as sustainable materials due to their degradability, recyclability, and versatility in various applications. However, the conventional production of poly(adipate)esters relies on energy‐intensive processes and petroleum‐derived adipic acid (AA), whose synthesis poses environmental concerns, including nitrous oxide

As a unique class of framework electronic materials, two‐dimensional conjugated metal‐organic frameworks (2D c‐MOFs) exhibit intrinsic porosity, superior electrical conductivity, and abundant active sites. These properties endow them with great potential in electrochemical lithium‐ion storage. However, the development of 2D c‐MOF‐based capacitors has encountered a bottleneck in enhancing Li‐ion storage

Polyhydroxyalkanoate (PHA) is a biodegradable polyester that can serve as a promising alternative to petrochemical plastics which present a serious source of pollution. PHA synthase (PhaC) is a key enzyme responsible for producing a wide variety of PHAs in microorganisms. Here we present crystal structures of full‐length PhaC from Aeromonas caviae, a high‐performance PhaC employed for industrial use

The catalytic enantioselective synthesis of aza‐sulfur(VI) compounds holds significant potential in pharmaceuticals owing to their broad spectrum of biological properties. Herein, we report the first N‐heterocyclic carbene (NHC)‐organocatalyzed enantioselective synthesis of cyclic sulfonimidamides (SIAs). The free N‐H containing SIAs often exhibit configurational lability through tautomerization. We

Cooperative intermolecular interactions, usually observed in solid state, can confer useful properties to stimuli‐responsive spin transition materials. Here we evidence for the first time intramolecular cooperativity between the two Fe‐Co subunits of a molecular cyanido‐bridged square Fe2Co2 Prussian blue analog (PBA) in solution, which upon single photon excitation sequentially undergo electron transfer

The controlled generation and utilization of singlet oxygen (1O2) are crucial for its diverse applications but remain challenging due to its high reactivity and short‐lived nature. Here, we report a box‐shaped metallacage prepared via multicomponent coordination‐driven self‐assembly using tetrapyridyl perylene diimide (PDI) and tetracarboxylate anthracene as building blocks. Upon photo‐irradiation

Photocatalytic CO2 conversion with H2O to carbonaceous fuels is a desirable strategy for CO2 management and solar utilization, yet its efficiency remains suboptimal. Herein, efficient and durable CO2 photoreduction is realized over a RuNPs/Ru‐PHI catalyst assembled by anchoring Ru single atoms (SAs) and nanoparticles (NPs) onto poly(heptazine imide) (PHI) via the in‐plane Ru‐N4 coordination and interfacial

Photocatalysis is a pivotal area in synthetic chemistry. Despite extensive application potential in nuclear industry, uranium‐based photocatalysts are historically limited to uranyl(VI/V) redox cycle. Here, we report the discovery of the first tetravalent uranium [U(IV)] photocatalyst that enables efficient C(sp3)–C(sp3) bond cleavage and formation under ideal visible light. The U(IV) alkoxy species

Although several diazotases have been recently reported, the details of the reaction mechanism are not yet understood. In this study, we investigated the mechanism of CmaA6, an ATP‐dependent diazotase that catalyzes the diazotization of 3‐aminocoumaric acid using nitrous acid. X‐ray crystallography and cryogenic electron microscopy‐single particle analysis revealed CmaA6 structures in the substrate‐free

Nickel‐based perovskite oxides are identified as promising candidates for oxygen evolution reaction (OER) catalysts in view of their low cost, highly tunable structure, and potential high activity. However, the performance and catalyst design are hindered by their sluggish surface reconstruction kinetics. We introduce a ferric ion pre‐etching strategy to enhance the surface reconstruction of typical

Mammalian secreted venoms mainly consist of peptides and proteases used for defense or predation. Blarina paralytic peptides (BPPs), mealworm‐targeting neurotoxins from shrew, are very similar to human synenkephalin. This peptide is released from proenkephalin in the brain along with opioid peptides that mediate analgesic and antidepressant effects, though its physiological function is unclear. Here

As a 4d–transition metal, the spin state of Pd is extremely difficult to directly regulate for the optimized d orbital states owing to the strong spin–orbit coupling effect and further extended d orbital. Herein, we devise "spin–selective electron donation" strategy to tune specific d orbital electrons of Pd inspired by Dewar−Chatt−Duncanson model theory. Co−S−Pd bridges with different spin–states

The light polarization modulation involves the capacity to respond selectively to light‐mater interaction and is dependent on the optical anisotropy of crystalline materials. The π‐conjugated component is almost typically utilized to produce such materials in the short‐wave ultraviolet region, however, the conflicting link between high optical anisotropy and strong layered habit is difficult to reconcile

closo‐Carboranes are icosahedral carbon‐boron clusters with unique properties and broad applicability. They particularly stand out in the context of drug development as privileged structural motifs for boron neutron capture therapy (BNCT) and as highly hydrophobic bioisosteres for the rotational volume of phenyl rings. Herein, we unveil the synthesis of N‐protected carboranyl analogs of β‐arylethylamines

This study presents a phosgene‐ and isocyanate‐free route for the synthesis of polyurethanes using (R)‐limonene as a bio‐based starting material. The synthesis of the cyclic limonene‐based carbamate monomer LU is achieved in high yields using dimethyl carbonate as a sustainable, less hazardous phosgene surrogate and is verified by NMR, SC‐XRD, ESI‐MS, GC‐MS, and elemental analysis. Polymerizations

J. Zhang, H. Zheng, F. Chen, Z. Wang, H. Li, F. Sun, D. Zhao, V. Valtchev, S. Qiu, Q. Fang, Angew. Chem. Int. Ed. 2025, 64, e202500161. https://doi.org/10.1002/anie.202500161 In the original publication, the description of [8+6]-c connectivity in the pdp network did not fully align with established topological nomenclature standards (Accounts of Chemical Research 2008, 41, 1782; Crystal Growth & Design

DNA methylation modulates gene expression without altering the DNA sequence. Aberrant DNA methylation patterns characterise a wide range of diseases, from cancer to neurological disorders, and serve as validated therapeutic targets and diagnostic tools. Among the proteins involved in DNA methylation regulation, the human reader Methyl‐CpG Binding Domain 2 protein (MBD2) exhibits a strong preference

This study presents the development and evaluation of five dyes with varying conjugated energy levels and donor‐π‐acceptor (D‐π‐A) structures as photoinitiators for free radical polymerization. Their photoinitiation efficiencies are systematically assessed under both visible‐light LED and sunlight. Notably, the conversions reach up to 81% within just 30 s under sunlight, demonstrating the ultra‐fast

CD59 is an immunomodulatory cell surface receptor associated with human disease. Despite its importance in complement regulation and bacterial pathogenesis, CD59 remains a challenging therapeutic target. Research to date has focused on antibody or protein‐based strategies. Here we present a new approach to target CD59 using macrocyclic peptides with low nanomolar affinity for CD59. Through X‐ray crystallographic

Constructing cluster‐based nodes and using them as catalytic sites can bring new structure and function for metal‐organic cages (MOCs). However, successful examples are very limited. Herein, we found that a 2‐mercapto‐5‐methyl‐1,3,4‐thiadiazole (Hmmt) based {Ni6} subunit is robust in building such MOCs. The {Ni6} node is based on the central Ni4 cubane and two wing Ni(II) ions with virtually three

Achieving ultrafast dissociation of photogenerated excitons and efficient charge transport within the photocatalyst is a fundamental issue. Additionally, enhancing the interaction between semiconductors and water is crucial for efficient photocatalytic water splitting. Herein, we synthesized a carboxylate‐based hydrophilic polymer, hPTB7‐Th. Exposed carboxylates enhance semiconductor‐water interfacial

Cold‐adapted bidomain enzymes have the potential to foster industrial sustainability by reducing energy consumption and greenhouse gas emissions. Despite their allure, these benefits are unattainable as the molecular basis of cold adaptation remains elusive and there are no strategies to guide the acquisition of this behavior. To uncover principles of cold adaptation, we selected the cold‐adapted Saccharophagus

Ammonia synthesis is a cornerstone in the chemical industry. Given the traditional Haber‐Bosch (H‐B) process requires very high temperature and pressure, it is imperative to develop catalysts capable of facilitating ammonia synthesis under mild conditions. In this work, a post‐metal replacement strategy is developed to improve the Fe loading in single‐atom Fe‐implanted N‐doped carbon catalysts. Starting

A one‐pot synthesis for previously unknown heavy homologues of group 9 metal carbynes [(Me3P)3CoºGeAr*] (1), [(Me3P)3RhºGeAr*] (2), [(Me3P)3IrºGeAr*] (3), [(Me3P)3IrºSnAr*] (5), and [(Et3P)3IrºPbAr*] (7) is presented [Ar* = C6H3‐2,6‐(Trip)2, Trip = 2,4,6‐C6H2iPr3]. During these preparations the tetrylidynes [(Me3P)3RhºSnAr*] (4), and [(Me3P)3RhºPbAr*] (6), were also prepared in a one‐pot procedure

The transamination reaction, which involves the conversion of one amine to another, traditionally relies on biological enzyme catalysts. Although chemists have recently developed a few transition metal‐catalyzed methods, mimicking these enzymes to interconvert amine groups in acyclic substrates via transamination metathesis of a single C(sp2)–N bond, transamination of cyclic tertiary amines has remained

Covalent drugs have experienced a revival in recent decades due to their advantageous pharmacodynamic profiles and targeting of “undruggable” proteins. However, balancing selectivity, reactivity, and potency is essential for the safe and effective drugs. Here we employ a cell‐selective bioorthogonal prodrug design to enhance the selectivity for covalent inhibitors without compromising the reactivity