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  • Protein targeting with SAF(er) electrophiles
    Nat. Chem. (IF 21.687) Pub Date : 2020-09-23
    Thomas E. Speltz; Raymond E. Moellering

    Electrophilic groups that undergo sulfur-exchange chemistry with protein nucleophiles can serve as the functional basis of chemical proteomic probes. A new addition to this class, sulfuramidimidoyl fluoride (SAF), which can be included in an array of covalent small molecule probes, exhibits a unique reactivity profile with proteins.

    更新日期:2020-09-25
  • What atoms do when they get together.
    Nat. Chem. (IF 21.687) Pub Date : 2020-09-23
    J J De Yoreo,B A Legg

    How atoms organize during the earliest stages of nucleation has been a subject of speculation for over a century. Using atomically resolved electron microscopy, the formation and ordering of metal clusters from individual atoms has now been observed in carbon nanotubes that serve as ‘test tubes’.

    更新日期:2020-09-23
  • A unit of revolution.
    Nat. Chem. (IF 21.687) Pub Date : 2020-09-23
    Michelle Francl

    Michelle Francl wonders if it is time to rethink the naming of units.

    更新日期:2020-09-23
  • A light touch for complex products.
    Nat. Chem. (IF 21.687) Pub Date : 2020-09-23
    Susannah Coote

    The [2+2] photocycloaddition of two double-bond moieties is arguably the most efficient way to form a four-membered ring, but this route is rarely used to construct azetidine rings. Now, the development of an isoxazoline carboxylate cycloaddition partner offers a general approach to synthesize diverse azetidine products.

    更新日期:2020-09-23
  • Symmetry in the making.
    Nat. Chem. (IF 21.687) Pub Date : 2020-09-23
    Susan M Reutzel-Edens

    After years of speculation on the origins of symmetry-making and -breaking during crystallization, time-resolved in situ scanning probe microscopy and all-atom molecular dynamics simulations have shown that the formation of olanzapine crystals largely occurs by the incorporation of centrosymmetric dimers into growth sites.

    更新日期:2020-09-23
  • Olanzapine crystal symmetry originates in preformed centrosymmetric solute dimers.
    Nat. Chem. (IF 21.687) Pub Date : 2020-09-23
    Monika Warzecha,Lakshmanji Verma,Blair F Johnston,Jeremy C Palmer,Alastair J Florence,Peter G Vekilov

    The symmetries of a crystal are notoriously uncorrelated to those of its constituent molecules. This symmetry breaking is typically thought to occur during crystallization. Here we demonstrate that one of the two symmetry elements of olanzapine crystals, an inversion centre, emerges in solute dimers extant in solution prior to crystallization. We combine time-resolved in situ scanning probe microscopy

    更新日期:2020-09-23
  • Synthesis of azetidines via visible-light-mediated intermolecular [2+2] photocycloadditions.
    Nat. Chem. (IF 21.687) Pub Date : 2020-09-23
    Marc R Becker,Emily R Wearing,Corinna S Schindler

    Intermolecular [2+2] photocycloadditions represent a powerful method for the synthesis of highly strained, four-membered rings. Although this approach is commonly employed for the synthesis of oxetanes and cyclobutanes, the synthesis of azetidines via intermolecular aza Paternò–Büchi reactions remains highly underdeveloped. Here we report a visible-light-mediated intermolecular aza Paternò–Büchi reaction

    更新日期:2020-09-23
  • Deep-neural-network solution of the electronic Schrödinger equation.
    Nat. Chem. (IF 21.687) Pub Date : 2020-09-23
    Jan Hermann,Zeno Schätzle,Frank Noé

    The electronic Schrödinger equation can only be solved analytically for the hydrogen atom, and the numerically exact full configuration-interaction method is exponentially expensive in the number of electrons. Quantum Monte Carlo methods are a possible way out: they scale well for large molecules, they can be parallelized and their accuracy has, as yet, been only limited by the flexibility of the wavefunction

    更新日期:2020-09-23
  • Chemistry's got talent.
    Nat. Chem. (IF 21.687) Pub Date : 2020-09-21
    Anne Pichon

    Manza B. J. Atkinson talks to Nature Chemistry about his path to become a chemist, and how he applies the scientific method to all aspects of his life — from financial analysis to coaching youth sports teams.

    更新日期:2020-09-21
  • The catalytic dwell in ATPases is not crucial for movement against applied torque.
    Nat. Chem. (IF 21.687) Pub Date : 2020-09-21
    Chen Bai,Mojgan Asadi,Arieh Warshel

    The ATPase-catalysed conversion of ATP to ADP is a fundamental process in biology. During the hydrolysis of ATP, the α3β3 domain undergoes conformational changes while the central stalk (γ/D) rotates unidirectionally. Experimental studies have suggested that different catalytic mechanisms operate depending on the type of ATPase, but the structural and energetic basis of these mechanisms remains unclear

    更新日期:2020-09-21
  • Macrocyclic colibactins.
    Nat. Chem. (IF 21.687) Pub Date : 2020-09-21
    Seth B Herzon

    更新日期:2020-09-21
  • Reply to: Macrocyclic colibactins.
    Nat. Chem. (IF 21.687) Pub Date : 2020-09-21
    Wenjun Zhang,Pei-Yuan Qian

    更新日期:2020-09-21
  • One-pot, room-temperature conversion of dinitrogen to ammonium chloride at a main-group element.
    Nat. Chem. (IF 21.687) Pub Date : 2020-09-14
    Marc-André Légaré,Guillaume Bélanger-Chabot,Maximilian Rang,Rian D Dewhurst,Ivo Krummenacher,Rüdiger Bertermann,Holger Braunschweig

    The industrial reduction of dinitrogen (N2) to ammonia is an energy-intensive process that consumes a considerable proportion of the global energy supply. As a consequence, species that can bind N2 and cleave its strong N–N bond under mild conditions have been sought for decades. Until recently, the only species known to support N2 fixation and functionalization were based on a handful of metals of

    更新日期:2020-09-14
  • Lysine acylation using conjugating enzymes for site-specific modification and ubiquitination of recombinant proteins.
    Nat. Chem. (IF 21.687) Pub Date : 2020-09-14
    Raphael Hofmann,Gaku Akimoto,Thomas G Wucherpfennig,Cathleen Zeymer,Jeffrey W Bode

    Enzymes are powerful tools for protein labelling due to their specificity and mild reaction conditions. Many protocols, however, are restricted to modifications at protein termini, rely on non-peptidic metabolites or require large recognition domains. Here we report a chemoenzymatic method, which we call lysine acylation using conjugating enzymes (LACE), to site-specifically modify folded proteins

    更新日期:2020-09-14
  • Quantum machine learning using atom-in-molecule-based fragments selected on the fly.
    Nat. Chem. (IF 21.687) Pub Date : 2020-09-14
    Bing Huang,O Anatole von Lilienfeld

    First-principles-based exploration of chemical space deepens our understanding of chemistry and might help with the design of new molecules, materials or experiments. Due to the computational cost of quantum chemistry methods and the immense number of theoretically possible stable compounds, comprehensive in silico screening remains prohibitive. To overcome this challenge, we combine atom-in-molecule-based

    更新日期:2020-09-14
  • Meta-DNA structures.
    Nat. Chem. (IF 21.687) Pub Date : 2020-09-07
    Guangbao Yao,Fei Zhang,Fei Wang,Tianhuan Peng,Hao Liu,Erik Poppleton,Petr Šulc,Shuoxing Jiang,Lan Liu,Chen Gong,Xinxin Jing,Xiaoguo Liu,Lihua Wang,Yan Liu,Chunhai Fan,Hao Yan

    DNA origami has emerged as a highly programmable method to construct customized objects and functional devices in the 10–100 nm scale. Scaling up the size of the DNA origami would enable many potential applications, which include metamaterial construction and surface-based biophysical assays. Here we demonstrate that a six-helix bundle DNA origami nanostructure in the submicrometre scale (meta-DNA)

    更新日期:2020-09-08
  • Using sulfuramidimidoyl fluorides that undergo sulfur(VI) fluoride exchange for inverse drug discovery.
    Nat. Chem. (IF 21.687) Pub Date : 2020-08-31
    Gabriel J Brighty,Rachel C Botham,Suhua Li,Luke Nelson,David E Mortenson,Gencheng Li,Christophe Morisseau,Hua Wang,Bruce D Hammock,K Barry Sharpless,Jeffery W Kelly

    Drug candidates that form covalent linkages with their target proteins have been underexplored compared with the conventional counterparts that modulate biological function by reversibly binding to proteins, in part due to concerns about off-target reactivity. However, toxicity linked to off-target reactivity can be minimized by using latent electrophiles that only become activated towards covalent

    更新日期:2020-09-01
  • Atomic mechanism of metal crystal nucleus formation in a single-walled carbon nanotube.
    Nat. Chem. (IF 21.687) Pub Date : 2020-08-28
    Kecheng Cao,Johannes Biskupek,Craig T Stoppiello,Robert L McSweeney,Thomas W Chamberlain,Zheng Liu,Kazu Suenaga,Stephen T Skowron,Elena Besley,Andrei N Khlobystov,Ute Kaiser

    Knowing how crystals nucleate at the atomic scale is crucial for understanding, and in turn controlling, the structure and properties of a wide variety of materials. However, because of the scale and highly dynamic nature of nuclei, the formation and early growth of nuclei are very difficult to observe. Here, we have employed single-walled carbon nanotubes as test tubes, and an ‘atomic injector’ coupled

    更新日期:2020-08-28
  • The complex chemical effects of COVID-19 shutdowns on air quality.
    Nat. Chem. (IF 21.687) Pub Date : 2020-08-25
    Jesse H Kroll,Colette L Heald,Christopher D Cappa,Delphine K Farmer,Juliane L Fry,Jennifer G Murphy,Allison L Steiner

    Stay-at-home policies invoked in response to COVID-19 have led to well-publicized drops in some air pollutants. The extent to which such reductions translate to improved air quality is dictated by not only emissions and meteorology, but also chemical transformations in the atmosphere.

    更新日期:2020-08-25
  • Practical science at home in a pandemic world.
    Nat. Chem. (IF 21.687) Pub Date : 2020-08-25
    Daren J Caruana,Christoph G Salzmann,Andrea Sella

    There are plenty of online resources to ensure that learning can continue for students who cannot access universities during a pandemic, but what options are there for practical aspects of science courses? Daren J. Caruana, Christoph G. Salzmann and Andrea Sella offer a manifesto for home-based experiments.

    更新日期:2020-08-25
  • A sound approach to self-assembly.
    Nat. Chem. (IF 21.687) Pub Date : 2020-08-24
    Charalampos G Pappas

    Controlling the formation of ordered and predictable patterns in dissipative reaction–diffusion processes is challenging. Now, liquid vibrations induced by audible sound have been shown to direct the formation of spatiotemporal patterns in switchable chemical systems and assemblies.

    更新日期:2020-08-24
  • Design of a small molecule that stimulates vascular endothelial growth factor A enabled by screening RNA fold-small molecule interactions.
    Nat. Chem. (IF 21.687) Pub Date : 2020-08-24
    Hafeez S Haniff,Laurent Knerr,Xiaohui Liu,Gogce Crynen,Jonas Boström,Daniel Abegg,Alexander Adibekian,Elizabeth Lekah,Kye Won Wang,Michael D Cameron,Ilyas Yildirim,Malin Lemurell,Matthew D Disney

    Vascular endothelial growth factor A (VEGFA) stimulates angiogenesis in human endothelial cells, and increasing its expression is a potential treatment for heart failure. Here, we report the design of a small molecule (TGP-377) that specifically and potently enhances VEGFA expression by the targeting of a non-coding microRNA that regulates its expression. A selection-based screen, named two-dimensional

    更新日期:2020-08-24
  • A platinum(II) metallonitrene with a triplet ground state.
    Nat. Chem. (IF 21.687) Pub Date : 2020-08-24
    Jian Sun,Josh Abbenseth,Hendrik Verplancke,Martin Diefenbach,Bas de Bruin,David Hunger,Christian Würtele,Joris van Slageren,Max C Holthausen,Sven Schneider

    Metallonitrenes (M–N) are complexes with a subvalent atomic nitrogen ligand that have been proposed as key reactive intermediates in nitrogen atom transfer reactions. However, in contrast to the common classes of nitride complexes (M≡N) and organic nitrenes (R–N), structurally and spectroscopically well defined ‘authentic’ metallonitrenes with a monovalent atomic nitrogen ligand remain elusive. Here

    更新日期:2020-08-24
  • Ribosomal synthesis and de novo discovery of bioactive foldamer peptides containing cyclic β-amino acids.
    Nat. Chem. (IF 21.687) Pub Date : 2020-08-24
    Takayuki Katoh,Toru Sengoku,Kunio Hirata,Kazuhiro Ogata,Hiroaki Suga

    Peptides that contain β-amino acids display stable secondary structures, such as helices and sheets, and are often referred to as foldamers. Cyclic β2,3-amino acids (cβAAs), such as 2-aminocyclohexanecarboxylic acid (2-ACHC), are strong helix/turn inducers due to their restricted conformations. Here we report the ribosomal synthesis of foldamer peptides that contain multiple, up to ten, consecutive

    更新日期:2020-08-24
  • Author Correction: Improving reaction prediction.
    Nat. Chem. (IF 21.687) Pub Date : 2020-08-21
    Ella M Gale,Derek J Durand

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

    更新日期:2020-08-22
  • The future iron age.
    Nat. Chem. (IF 21.687) Pub Date : 2020-08-17
    Julia A Weinstein

    Recent research has shown that vibronic coherences are one of the primary drivers for ultrafast light-induced processes. Now, ultrafast spectroscopy has been used to uncover vibronic coherences in the excited-state dynamics of an iron complex, leading to its redesign and the drastic prolonging of its excited-state lifetime.

    更新日期:2020-08-17
  • A convenient P- source.
    Nat. Chem. (IF 21.687) Pub Date : 2020-08-17
    David Scheschkewitz

    White phosphorus is a prominent source of P atoms but has remained difficult to activate without using transition metals. Now, a bidentate ligand based on silicon(ii) donors has successfully stabilized a P2 moiety, and the resulting complex acts as a transfer reagent for P– anions.

    更新日期:2020-08-17
  • Predictable phase-separated proteins.
    Nat. Chem. (IF 21.687) Pub Date : 2020-08-17
    Soumik Ray,Samir K Maji

    An approach to design artificial intrinsically disordered proteins using a short peptide as a repeating unit has been reported. This design enables the phase behaviour of the protein to be finely tuned inside cells and enabled the formation of phase-separated condensates that can modulate chemical reactions.

    更新日期:2020-08-17
  • A bis(silylene)-stabilized diphosphorus compound and its reactivity as a monophosphorus anion transfer reagent.
    Nat. Chem. (IF 21.687) Pub Date : 2020-08-17
    Yuwen Wang,Tibor Szilvási,Shenglai Yao,Matthias Driess

    In contrast to the well-established transition-metal-mediated activation of white phosphorus (P4), the metal-free direct functionalization of P4 has remained rare. The conversion of P4 into a reactive zero-valent diphosphorus compound (P2) has proven challenging to carry out without relying on metal reactivity. Herein, we describe the facile degradation of P4 mediated by two divalent silicon atoms

    更新日期:2020-08-17
  • Complexity emerges from chemistry.
    Nat. Chem. (IF 21.687) Pub Date : 2020-08-17
    Helena S Azevedo,Sarah L Perry,Peter A Korevaar,Dibyendu Das

    Chemical systems can show complex behaviour that is not seen in individual molecules or reactions. Helena S. Azevedo, Sarah L. Perry, Peter A. Korevaar, and Dibyendu Das report on the emergence of this complex behaviour, which was discussed at the Virtual Symposium on Systems Chemistry

    更新日期:2020-08-17
  • Challenging nature's preference for methylation.
    Nat. Chem. (IF 21.687) Pub Date : 2020-08-17
    Jennifer N Andexer,Andrea Rentmeister

    Enzymes that methylate using S-adenosyl-l-methionine — nature’s methyliodide — are abundant and often promiscuous; however, a preference for alkylation over methylation has been neither observed in nature nor engineered. Now, carboxymethylation has been demonstrated using engineered methyltransferases.

    更新日期:2020-08-17
  • A diverse view of science to catalyse change.
    Nat. Chem. (IF 21.687) Pub Date : 2020-08-17
    César A Urbina-Blanco,Safia Z Jilani,Isaiah R Speight,Michael J Bojdys,Tomislav Friščić,J Fraser Stoddart,Toby L Nelson,James Mack,Renã A S Robinson,Emanuel A Waddell,Jodie L Lutkenhaus,Murrell Godfrey,Martine I Abboud,Stephen O Aderinto,Damilola Aderohunmu,Lučka Bibič,João Borges,Vy M Dong,Lori Ferrins,Fun Man Fung,Torsten John,Felicia P L Lim,Sarah L Masters,Dickson Mambwe,Pall Thordarson,Maria-Magdalena

    Valuing diversity leads to scientific excellence, the progress of science and, most importantly, it is simply the right thing to do. We must value diversity not only in words, but also in actions.

    更新日期:2020-08-17
  • Post-translational formation of strained cyclophanes in bacteria.
    Nat. Chem. (IF 21.687) Pub Date : 2020-08-17
    Thi Quynh Ngoc Nguyen,Yi Wei Tooh,Ryosuke Sugiyama,Thi Phuong Diep Nguyen,Mugilarasi Purushothaman,Li Chuan Leow,Karyna Hanif,Rubin How Sheng Yong,Irene Agatha,Fernaldo R Winnerdy,Muriel Gugger,Anh Tuân Phan,Brandon I Morinaka

    Cyclic peptide natural products have served as important drug molecules, with several examples used clinically. Enzymatic or chemical macrocyclization is the key transformation for constructing these chemotypes. Methods to generate new and diverse cyclic peptide scaffolds enabling the modular and predictable synthesis of peptide libraries are desirable in drug discovery platforms. Here we identify

    更新日期:2020-08-17
  • Publisher Correction: Time-dependent enantiodivergent synthesis via sequential kinetic resolution.
    Nat. Chem. (IF 21.687) Pub Date : 2020-08-11
    Hang-Fei Tu,Pusu Yang,Zi-Hua Lin,Chao Zheng,Shu-Li You

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

    更新日期:2020-08-11
  • Audible sound-controlled spatiotemporal patterns in out-of-equilibrium systems.
    Nat. Chem. (IF 21.687) Pub Date : 2020-08-10
    Ilha Hwang,Rahul Dev Mukhopadhyay,Prabhu Dhasaiyan,Seoyeon Choi,Soo-Young Kim,Young Ho Ko,Kangkyun Baek,Kimoon Kim

    Naturally occurring spatiotemporal patterns typically have a predictable pattern design and are reproducible over several cycles. However, the patterns obtained from artificially designed out-of-equilibrium chemical oscillating networks (such as the Belousov–Zhabotinsky reaction for example) are unpredictable and difficult to control spatiotemporally, albeit reproducible over subsequent cycles. Here

    更新日期:2020-08-10
  • A monodomain class II terpene cyclase assembles complex isoprenoid scaffolds.
    Nat. Chem. (IF 21.687) Pub Date : 2020-08-10
    Philipp Moosmann,Felix Ecker,Stefan Leopold-Messer,Jackson K B Cahn,Cora L Dieterich,Michael Groll,Jörn Piel

    Class II terpene cyclases, such as oxidosqualene and squalene-hopene cyclases, catalyse some of the most complex polycyclization reactions. They minimally exhibit a β,γ-didomain architecture that has been evolutionarily repurposed in a wide range of terpene-processing enzymes and likely resulted from a fusion of unidentified monodomain proteins. Although single domain class I terpene cyclases have

    更新日期:2020-08-10
  • De novo engineering of intracellular condensates using artificial disordered proteins.
    Nat. Chem. (IF 21.687) Pub Date : 2020-08-03
    Michael Dzuricky,Bradley A Rogers,Abdulla Shahid,Paul S Cremer,Ashutosh Chilkoti

    Phase separation of intrinsically disordered proteins (IDPs) is a remarkable feature of living cells to dynamically control intracellular partitioning. Despite the numerous new IDPs that have been identified, progress towards rational engineering in cells has been limited. To address this limitation, we systematically scanned the sequence space of native IDPs and designed artificial IDPs (A-IDPs) with

    更新日期:2020-08-03
  • Knotting a molecular strand can invert macroscopic effects of chirality.
    Nat. Chem. (IF 21.687) Pub Date : 2020-08-03
    Nathalie Katsonis,Federico Lancia,David A Leigh,Lucian Pirvu,Alexander Ryabchun,Fredrik Schaufelberger

    Transferring structural information from the nanoscale to the macroscale is a promising strategy for developing adaptive and dynamic materials. Here we demonstrate that the knotting and unknotting of a molecular strand can be used to control, and even invert, the handedness of a helical organization within a liquid crystal. An oligodentate tris(2,6-pyridinedicarboxamide) strand with six point-chiral

    更新日期:2020-08-03
  • Complexes featuring a linear [N≡U≡N] core isoelectronic to the uranyl cation.
    Nat. Chem. (IF 21.687) Pub Date : 2020-08-03
    Stefan S Rudel,H Lars Deubner,Matthias Müller,Antti J Karttunen,Florian Kraus

    The aqueous chemistry of uranium is dominated by the linear uranyl cation [UO2]2+, yet the isoelectronic nitrogen-based analogue of this ubiquitous cation, molecular [UN2], has so far only been observed in an argon matrix. Here, we present three different complexes of [UN2] obtained by the reaction of the uranium pentahalides UCl5 or UBr5 with anhydrous liquid ammonia. The [UN2] moieties are linear

    更新日期:2020-08-03
  • CD44 regulates epigenetic plasticity by mediating iron endocytosis.
    Nat. Chem. (IF 21.687) Pub Date : 2020-08-03
    Sebastian Müller,Fabien Sindikubwabo,Tatiana Cañeque,Anne Lafon,Antoine Versini,Bérangère Lombard,Damarys Loew,Ting-Di Wu,Christophe Ginestier,Emmanuelle Charafe-Jauffret,Adeline Durand,Céline Vallot,Sylvain Baulande,Nicolas Servant,Raphaël Rodriguez

    CD44 is a transmembrane glycoprotein linked to various biological processes reliant on epigenetic plasticity, which include development, inflammation, immune responses, wound healing and cancer progression. Although it is often referred to as a cell surface marker, the functional regulatory roles of CD44 remain elusive. Here we report the discovery that CD44 mediates the endocytosis of iron-bound hyaluronates

    更新日期:2020-08-03
  • The centenary (maybe) of the hydrogen bond.
    Nat. Chem. (IF 21.687) Pub Date : 2020-07-27
    Bruce C Gibb

    Despite the romantic mythology that often accompanies stories of scientific discovery, pinpointing the exact moment in history when a new concept emerged is often a matter of debate — and the hydrogen bond is no exception explains Bruce C. Gibb.

    更新日期:2020-07-27
  • Acyltransferase that catalyses the condensation of polyketide and peptide moieties of goadvionin hybrid lipopeptides.
    Nat. Chem. (IF 21.687) Pub Date : 2020-07-27
    Ryosuke Kozakai,Takuto Ono,Shotaro Hoshino,Hidenori Takahashi,Yohei Katsuyama,Yoshinori Sugai,Taro Ozaki,Kazuya Teramoto,Kanae Teramoto,Koichi Tanaka,Ikuro Abe,Shumpei Asamizu,Hiroyasu Onaka

    Fusions of fatty acids and peptides expand the structural diversity of natural products; however, polyketide/ribosomally synthesized and post-translationally modified peptides (PK/RiPPs) hybrid lipopeptides are relatively rare. Here we report a family of PK/RiPPs called goadvionins, which inhibit the growth of Gram-positive bacteria, and an acyltransferase, GdvG, which catalyses the condensation of

    更新日期:2020-07-27
  • Stereoselective access to [5.5.0] and [4.4.1] bicyclic compounds through Pd-catalysed divergent higher-order cycloadditions.
    Nat. Chem. (IF 21.687) Pub Date : 2020-07-27
    Li-Cheng Yang,Ya-Nong Wang,Ruoyang Liu,Yixin Luo,Xiao Qian Ng,Binmiao Yang,Zi-Qiang Rong,Yu Lan,Zhihui Shao,Yu Zhao

    Medium-sized rings, including those embedded in bridged and fused bicyclic scaffolds, are common core structures of myriad bioactive molecules. Among various synthetic strategies towards their synthesis, intermolecular higher-order cycloaddition provides great potential to build complex medium-sized rings from simple building blocks. Unfortunately, such transformations are often plagued with competitive

    更新日期:2020-07-27
  • Author Correction: Molecular engineering of organic-inorganic hybrid perovskites quantum wells.
    Nat. Chem. (IF 21.687) Pub Date : 2020-07-20
    Yao Gao,Enzheng Shi,Shibin Deng,Stephen B Shiring,Jordan M Snaider,Chao Liang,Biao Yuan,Ruyi Song,Svenja M Janke,Alexander Liebman-Peláez,Pilsun Yoo,Matthias Zeller,Bryan W Boudouris,Peilin Liao,Chenhui Zhu,Volker Blum,Yi Yu,Brett M Savoie,Libai Huang,Letian Dou

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

    更新日期:2020-07-23
  • Expanding the reverse transcription toolbox.
    Nat. Chem. (IF 21.687) Pub Date : 2020-07-20
    Melanie Henkel,Andreas Marx

    Tailor-made reverse transcriptases are used in molecular biology and synthetic genetics. However, re-engineering these enzymes to work with non-natural nucleic acids is difficult and requires powerful directed evolution strategies. Now, an adaptable selection approach has been demonstrated for the evolution of new reverse transcriptases.

    更新日期:2020-07-20
  • Taking titanium for a spin.
    Nat. Chem. (IF 21.687) Pub Date : 2020-07-20
    Kelsey A Collins,Danna E Freedman

    Spin-1/2 kagome lattice antiferromagnets are geometrically frustrated materials poised to host yet-unobserved behaviours. Now, such a lattice has been prepared that shows no structural distortions and hosts its spin in the dxy orbital of d1 Ti3+ centres, rather than the more-widely investigated d9 Cu2+ ions.

    更新日期:2020-07-20
  • Discovery and evolution of RNA and XNA reverse transcriptase function and fidelity.
    Nat. Chem. (IF 21.687) Pub Date : 2020-07-20
    Gillian Houlihan,Sebastian Arangundy-Franklin,Benjamin T Porebski,Nithya Subramanian,Alexander I Taylor,Philipp Holliger

    The ability of reverse transcriptases (RTs) to synthesize a complementary DNA from natural RNA and a range of unnatural xeno nucleic acid (XNA) template chemistries, underpins key methods in molecular and synthetic genetics. However, RTs have proven challenging to discover and engineer, in particular for the more divergent XNA chemistries. Here we describe a general strategy for the directed evolution

    更新日期:2020-07-20
  • Three concomitant C-C dissociation pathways during the mechanical activation of an N-heterocyclic carbene precursor.
    Nat. Chem. (IF 21.687) Pub Date : 2020-07-20
    Robert Nixon,Guillaume De Bo

    Chemical reactions usually proceed through a radical, concerted or ionic mechanism; transformations in which all three mechanisms occur are rare. In polymer mechanochemistry, a mechanical force, transduced along polymer chains, is used to activate covalent bonds in mechanosensitive molecules (mechanophores). Cleavage of a C–C bond often follows a homolytic pathway, but some mechanophores have also

    更新日期:2020-07-20
  • Tracking the ultraviolet-induced photochemistry of thiophenone during and after ultrafast ring opening.
    Nat. Chem. (IF 21.687) Pub Date : 2020-07-20
    Shashank Pathak,Lea M Ibele,Rebecca Boll,Carlo Callegari,Alexander Demidovich,Benjamin Erk,Raimund Feifel,Ruaridh Forbes,Michele Di Fraia,Luca Giannessi,Christopher S Hansen,David M P Holland,Rebecca A Ingle,Robert Mason,Oksana Plekan,Kevin C Prince,Arnaud Rouzée,Richard J Squibb,Jan Tross,Michael N R Ashfold,Basile F E Curchod,Daniel Rolles

    Photoinduced isomerization reactions lie at the heart of many chemical processes in nature. The mechanisms of such reactions are determined by a delicate interplay of coupled electronic and nuclear dynamics occurring on the femtosecond scale, followed by the slower redistribution of energy into different vibrational degrees of freedom. Here we apply time-resolved photoelectron spectroscopy with a seeded

    更新日期:2020-07-20
  • Single-molecule visualization of DNA G-quadruplex formation in live cells.
    Nat. Chem. (IF 21.687) Pub Date : 2020-07-20
    Marco Di Antonio,Aleks Ponjavic,Antanas Radzevičius,Rohan T Ranasinghe,Marco Catalano,Xiaoyun Zhang,Jiazhen Shen,Lisa-Maria Needham,Steven F Lee,David Klenerman,Shankar Balasubramanian

    Substantial evidence now exists to support that formation of DNA G-quadruplexes (G4s) is coupled to altered gene expression. However, approaches that allow us to probe G4s in living cells without perturbing their folding dynamics are required to understand their biological roles in greater detail. Herein, we report a G4-specific fluorescent probe (SiR-PyPDS) that enables single-molecule and real-time

    更新日期:2020-07-20
  • Barcoded DNA origami structures for multiplexed optimization and enrichment of DNA-based protein-binding cavities.
    Nat. Chem. (IF 21.687) Pub Date : 2020-07-13
    Ali Aghebat Rafat,Sandra Sagredo,Melissa Thalhammer,Friedrich C Simmel

    Simultaneous binding of molecules by multiple binding partners is known to strongly reduce the apparent dissociation constant of the corresponding molecular complexes, and can be used to achieve strong, non-covalent molecular interactions. Based on this principle, efficient binding of proteins to DNA nanostructures has been achieved previously by placing several aptamers in close proximity to each

    更新日期:2020-07-13
  • Harder, better, faster.
    Nat. Chem. (IF 21.687) Pub Date : 2020-07-10
    Danielle Schultz,Louis-Charles Campeau

    The gap between fundamental academic research and the applied industrial research that is necessary to ensure real-world applications can be bridged by engaging in well-defined collaborative academia–industry projects and fostering better communication between the scientists involved in them.

    更新日期:2020-07-10
  • Identification of targets of AMPylating Fic enzymes by co-substrate-mediated covalent capture.
    Nat. Chem. (IF 21.687) Pub Date : 2020-07-06
    Burak Gulen,Marie Rosselin,Joel Fauser,Michael F Albers,Christian Pett,Christoph Krisp,Vivian Pogenberg,Hartmut Schlüter,Christian Hedberg,Aymelt Itzen

    Various pathogenic bacteria use post-translational modifications to manipulate the central components of host cell functions. Many of the enzymes released by these bacteria belong to the large Fic family, which modify targets with nucleotide monophosphates. The lack of a generic method for identifying the cellular targets of Fic family enzymes hinders investigation of their role and the effect of the

    更新日期:2020-07-06
  • Structural snapshots of the minimal PKS system responsible for octaketide biosynthesis.
    Nat. Chem. (IF 21.687) Pub Date : 2020-07-06
    Alois Bräuer,Qiuqin Zhou,Gina L C Grammbitter,Maximilian Schmalhofer,Michael Rühl,Ville R I Kaila,Helge B Bode,Michael Groll

    Type II polyketide synthases (PKSs) are multi-enzyme complexes that produce secondary metabolites of medical relevance. Chemical backbones of such polyketides are produced by minimal PKS systems that consist of a malonyl transacylase, an acyl carrier protein and an α/β heterodimeric ketosynthase. Here, we present X-ray structures of all ternary complexes that constitute the minimal PKS system for anthraquinone

    更新日期:2020-07-06
  • Tunable exciton binding energy in 2D hybrid layered perovskites through donor-acceptor interactions within the organic layer.
    Nat. Chem. (IF 21.687) Pub Date : 2020-07-06
    James V Passarelli,Catherine M Mauck,Samuel W Winslow,Collin F Perkinson,Jacob C Bard,Hiroaki Sai,Kristopher W Williams,Ashwin Narayanan,Daniel J Fairfield,Mark P Hendricks,William A Tisdale,Samuel I Stupp

    The strength of electrostatic interactions within semiconductors strongly affects their performance in optoelectronic devices. An important target is the tuning of a material’s exciton binding energy—the energy binding an electron–hole pair through the electrostatic Coulomb force—independent of its electronic band gap. Here, we report on the doping of a family of two-dimensional hybrid perovskites

    更新日期:2020-07-06
  • Fast motion of molecular rotors in metal-organic framework struts at very low temperatures.
    Nat. Chem. (IF 21.687) Pub Date : 2020-07-06
    Jacopo Perego,Silvia Bracco,Mattia Negroni,Charl X Bezuidenhout,Giacomo Prando,Pietro Carretta,Angiolina Comotti,Piero Sozzani

    The solid state is typically not well suited to sustaining fast molecular motion, but in recent years a variety of molecular machines, switches and rotors have been successfully engineered within porous crystals and on surfaces. Here we show a fast-rotating molecular rotor within the bicyclopentane–dicarboxylate struts of a zinc-based metal–organic framework—the carboxylate groups anchored to the metal

    更新日期:2020-07-06
  • Time-dependent enantiodivergent synthesis via sequential kinetic resolution.
    Nat. Chem. (IF 21.687) Pub Date : 2020-06-29
    Hang-Fei Tu,Pusu Yang,Zi-Hua Lin,Chao Zheng,Shu-Li You

    The preparation of both enantiomers of chiral molecules is among the most fundamental tasks in organic synthesis, medicinal chemistry and materials science. Achieving this goal typically requires reversing the absolute configuration of the chiral component employed in the reaction system that is being used. The task becomes challenging when the natural source of the chiral component is not available

    更新日期:2020-06-29
  • Dual electrocatalysis enables enantioselective hydrocyanation of conjugated alkenes.
    Nat. Chem. (IF 21.687) Pub Date : 2020-06-29
    Lu Song,Niankai Fu,Brian G Ernst,Wai Hang Lee,Michael O Frederick,Robert A DiStasio,Song Lin

    Chiral nitriles and their derivatives are prevalent in pharmaceuticals and bioactive compounds. Enantioselective alkene hydrocyanation represents a convenient and efficient approach for synthesizing these molecules. However, a generally applicable method featuring a broad substrate scope and high functional group tolerance remains elusive. Here, we address this long-standing synthetic problem using

    更新日期:2020-06-29
  • NH3 formation from N2 and H2 mediated by molecular tri-iron complexes.
    Nat. Chem. (IF 21.687) Pub Date : 2020-06-29
    Matthias Reiners,Dirk Baabe,Katharina Münster,Marc-Kevin Zaretzke,Matthias Freytag,Peter G Jones,Yannick Coppel,Sébastien Bontemps,Iker Del Rosal,Laurent Maron,Marc D Walter

    Living systems carry out the reduction of N2 to ammonia (NH3) through a series of protonation and electron transfer steps under ambient conditions using the enzyme nitrogenase. In the chemical industry, the Haber–Bosch process hydrogenates N2 but requires high temperatures and pressures. Both processes rely on iron-based catalysts, but molecular iron complexes that promote the formation of NH3 on addition

    更新日期:2020-06-29
  • Synthesis of a d1-titanium fluoride kagome lattice antiferromagnet.
    Nat. Chem. (IF 21.687) Pub Date : 2020-06-29
    Ningxin Jiang,Arun Ramanathan,John Bacsa,Henry S La Pierre

    The kagome lattice, composed of a planar array of corner-sharing triangles, is one of the most geometrically frustrated lattices. The realization of a spin S = 1/2 kagome lattice antiferromagnet is of particular interest because it may host an exotic form of matter, a quantum spin liquid state, which shows long-range entanglement and no magnetic ordering down to 0 K. A few S = 1/2 kagome lattice antiferromagnets

    更新日期:2020-06-29
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