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The biophysical requirements that govern the efficient endosomal escape of designed mini-proteins Nat. Chem. (IF 20.2) Pub Date : 2025-07-08 Jonathan Giudice, Daniel D. Brauer, Madeline Zoltek, Angel L. Vázquez-Maldonado, Neville Dadina, Mark Kelly, Alanna Schepartz
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A bright comeback for peri-xanthenoxanthene Nat. Chem. (IF 20.2) Pub Date : 2025-07-03 Davide Zanetti, Cristian De Luca, Davide Bonifazi
Davide Zanetti, Cristian De Luca, and Davide Bonifazi discuss the resurgence of peri-xanthenoxanthene from a forgotten dye into a versatile organic semiconductor and sustainable photocatalyst, emphasizing its importance in photoredox catalysis.
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Metal-centred states control carrier lifetimes in transition metal oxide photocatalysts Nat. Chem. (IF 20.2) Pub Date : 2025-07-02 Michael Sachs, Liam Harnett-Caulfield, Ernest Pastor, Bernadette Davies, Daniel J. C. Sowood, Benjamin Moss, Andreas Kafizas, Jenny Nelson, Aron Walsh, James R. Durrant
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Homotypic RNA clustering accompanies a liquid-to-solid transition inside the core of multi-component biomolecular condensates Nat. Chem. (IF 20.2) Pub Date : 2025-07-02 Tharun Selvam Mahendran, Gable M. Wadsworth, Anurag Singh, Ritika Gupta, Priya R. Banerjee
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A high-five for praseodymium Nat. Chem. (IF 20.2) Pub Date : 2025-06-27 Florian R. Neururer, Stephan Hohloch
The lanthanides comprise a series of 15 elements that have applications in many modern technologies, including magnetic materials and optics. Their chemistry has been traditionally dominated by the +II and +III oxidation states; higher oxidation states, except in the case of cerium, have long been deemed unreachable. Now, an example of a stable praseodymium complex in the formal oxidation state +V
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Mechanochemical pathway for converting fluoropolymers to fluorochemicals Nat. Chem. (IF 20.2) Pub Date : 2025-06-27 Masashi Hattori, Debarshi Saha, Muhamad Zulfaqar Bacho, Norio Shibata
The growing demand for fluorochemicals has increased the production of toxic hydrogen fluoride (HF)—a widely used fluorination agent—from mineral fluorspar (CaF2). Although potassium fluoride (KF) is a safer alternative fluorination agent, its production still involves HF as an intermediate. Simultaneously, the disposal of fluoropolymer waste, especially polyvinylidene fluoride (PVDF), poses environmental
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Expedited access to polyunsaturated fatty acids and biofunctional analogues by full solid-phase synthesis Nat. Chem. (IF 20.2) Pub Date : 2025-06-25 Yutaro Saito, Mayuko Akita, Azusa Saika, Yusuke Sano, Masashi Hotta, Jumpei Morimoto, Akiharu Uwamizu, Junken Aoki, Takahiro Nagatake, Jun Kunisawa, Shinsuke Sando
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New-to-nature biocompatible chemistry for plastic waste upcycling Nat. Chem. (IF 20.2) Pub Date : 2025-06-23 Wei Long Soon, Hui Qing Chong, Jee Loon Foo, Matthew Wook Chang
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A biocompatible Lossen rearrangement in Escherichia coli Nat. Chem. (IF 20.2) Pub Date : 2025-06-23 Nick W. Johnson, Marcos Valenzuela-Ortega, Thomas W. Thorpe, Yuta Era, Annemette Kjeldsen, Keith Mulholland, Stephen Wallace
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Biosynthesis of an elusive sulfur-containing functional group Nat. Chem. (IF 20.2) Pub Date : 2025-06-23 Sabina J. Maurer, Monica E. McCallum
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Adaptive dynamic kinetic resolution enables alteration of chiral induction with ring sizes Nat. Chem. (IF 20.2) Pub Date : 2025-06-23 Bangkui Yu, Yao Huang, Haocheng Zhang, Hanmin Huang
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Accessing sulfonamides via formal SO2 insertion into C–N bonds Nat. Chem. (IF 20.2) Pub Date : 2025-06-20 Myojeong Kim, Carys E. Obertone, Christopher B. Kelly, Christopher A. Reiher, Cristina Grosanu, James C. Robertson, Mark D. Levin
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A lanthanide–carbon triple bond stabilized within a fullerene cage Nat. Chem. (IF 20.2) Pub Date : 2025-06-19 Hongjie Jiang, Jing Zhao, Qingyu Meng, Xiao-Kun Zhao, Min Guo, Han-Shi Hu, Jun Li, Ning Chen
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Reversible formation and control of linear conjugation in polymers Nat. Chem. (IF 20.2) Pub Date : 2025-06-19 Yanyun Wu, Jiongjiang Liu, Mengya Wang, Xinzhou Wu, Wanan Cai, Haijun Niu, Kai Lang
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Function without form in synthetic polymers mimicking protein hydration Nat. Chem. (IF 20.2) Pub Date : 2025-06-18 Michael A. Webb
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On-DNA C–H functionalization of electron-rich arenes for DNA-encoded libraries Nat. Chem. (IF 20.2) Pub Date : 2025-06-16 Eduardo de Pedro Beato, Luca Torkowski, Philipp Hartmann, Lara Vogelsang, Karl-Josef Dietz, Tobias Ritter
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Synthesis of diverse terpenoid frameworks via enzyme-enabled abiotic scaffold hop Nat. Chem. (IF 20.2) Pub Date : 2025-06-16 Heping Deng, Junhong Yang, Fuzhuo Li, Jian Li, Hans Renata
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Oxygen transposition of formamide to α-aminoketone moiety in a carbene-initiated domino reaction Nat. Chem. (IF 20.2) Pub Date : 2025-06-13 Yan Luo, Guanglong Huang, Kuiling Ding, Xiao-Song Xue, Xiaoming Wang
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Modular alkyl growth in amines via the selective insertion of alkynes into C–C bonds Nat. Chem. (IF 20.2) Pub Date : 2025-06-12 Xin-Yue Zhou, Lu Liu, Hairong Lyu, Xiao-Chen Wang
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A designer minimalistic model parallels the phase-separation-mediated assembly and biophysical cues of extracellular matrix Nat. Chem. (IF 20.2) Pub Date : 2025-06-09 Xian Xie, Tianjie Li, Linjie Ma, Jiahao Wu, Yajing Qi, Boguang Yang, Zhuo Li, Zhinan Yang, Kunyu Zhang, Zhiqin Chu, To Ngai, Jiang Xia, Yi Wang, Pengchao Zhao, Liming Bian
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Linked in with lignin Nat. Chem. (IF 20.2) Pub Date : 2025-06-05 Moses Dike, Shudipto Konika Dishari
Moses Dike and Shudipto Konika Dishari explore lignin’s historic journey alongside human civilization and showcase its game-changing potential to drive sustainability without compromising performance.
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Controlling our online professional persona Nat. Chem. (IF 20.2) Pub Date : 2025-06-05 Shira Joudan
Modern scientists exist within the digital world. Shira Joudan describes how an online presence is beneficial to researchers, and what a baseline presence can look like.
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Information propagation through enzyme-free catalytic templating of DNA dimerization with weak product inhibition Nat. Chem. (IF 20.2) Pub Date : 2025-06-05 Javier Cabello-Garcia, Rakesh Mukherjee, Wooli Bae, Guy-Bart V. Stan, Thomas E. Ouldridge
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A selenoxide for single-atom protein modification of tyrosine residues enabled by water-resistant chalcogen and hydrogen bonding Nat. Chem. (IF 20.2) Pub Date : 2025-06-04 Songyun Lin, Marina Hirao, Philipp Hartmann, Markus Leutzsch, Marie Sophie Sterling, Alessandro Vetere, Sandra Klimmek, Heike Hinrichs, Johanna Marie Mengeler, Johannes Lehmann, Jan Samsonowicz-Gόrski, Florian Berger, Tobias Ritter
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Building ultramicroporous zirconium metal‒organic frameworks with ligands of high coordination density through a reticular approach Nat. Chem. (IF 20.2) Pub Date : 2025-06-04 Liang Yu, Shenfang Li, Xin Zhou, Bochun Zhang, Kang Zhou, Qibin Xia, Sujing Wang, Jing Li, Hao Wang
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Interfacial assembly of biomimetic MOF-based porous membranes on coacervates to build complex protocells and prototissues Nat. Chem. (IF 20.2) Pub Date : 2025-06-04 Yanglimin Ji, Yiyang Lin, Yan Qiao
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Gold redox catalysis with hydrogen peroxide Nat. Chem. (IF 20.2) Pub Date : 2025-05-29 Sandip A. Bhadange, Nitin T. Patil
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Bidentate N-ligand-assisted gold redox catalysis with hydrogen peroxide Nat. Chem. (IF 20.2) Pub Date : 2025-05-29 Hongwei Shi, Matthias Rudolph, Jun Li, Yu Tian, Martin C. Dietl, Hadil Alshurafa, Yaowen Liu, Tao Wang, Henrik Habeck, Philipp M. Stein, Petra Krämer, Frank Rominger, Thomas Oeser, Ning Jiao, A. Stephen K. Hashmi
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Trinucleotide substrates under pH–freeze–thaw cycles enable open-ended exponential RNA replication by a polymerase ribozyme Nat. Chem. (IF 20.2) Pub Date : 2025-05-28 James Attwater, Teresa L. Augustin, Joseph F. Curran, Samantha L. Y. Kwok, Luis Ohlendorf, Edoardo Gianni, Philipp Holliger
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Photoinduced bulk polymerization strategy in melt state for recyclable polydiene derivatives Nat. Chem. (IF 20.2) Pub Date : 2025-05-28 Pengfei Wu, Qixuan Hu, Andrew V. Marquardt, Lawal A. Ogunfowora, Jeong Hui Kim, Yuanhao Tang, Chenjian Lin, Brett M. Savoie, Letian Dou
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Structure-informed design of an ultrabright RNA-activated fluorophore Nat. Chem. (IF 20.2) Pub Date : 2025-05-28 Mo Yang, Peri R. Prestwood, Luiz F. M. Passalacqua, Sumirtha Balaratnam, Christopher R. Fullenkamp, J. Winston Arney, Kevin M. Weeks, Adrian Ferre-D’Amare, John S. Schneekloth
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Mimicking the structure and function of tau folds associated with disease Nat. Chem. (IF 20.2) Pub Date : 2025-05-23 Joost Schymkowitz, Frederic Rousseau
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Abiotic lipid metabolism enables membrane plasticity in artificial cells Nat. Chem. (IF 20.2) Pub Date : 2025-05-22 Alessandro Fracassi, Andrés Seoane, Roberto J. Brea, Hong-Guen Lee, Alexander Harjung, Neal K. Devaraj
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Author Correction: Moiré two-dimensional covalent organic framework superlattices Nat. Chem. (IF 20.2) Pub Date : 2025-05-21 Gaolei Zhan, Brecht Koek, Yijia Yuan, Yikuan Liu, Vipin Mishra, Veniero Lenzi, Karol Strutyński, Chunxiao Li, Rongrong Zhang, Xin Zhou, Hwa Seob Choi, Zhen-Feng Cai, Joaquín Almarza, Kunal S. Mali, Aurelio Mateo-Alonso, Manuel Melle Franco, Yihan Zhu, Steven De Feyter, Kian Ping Loh
Correction to: Nature Chemistry https://doi.org/10.1038/s41557-025-01748-5, published online 20 February 2025.
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Squeezing the mechanism out of photochemical reactions Nat. Chem. (IF 20.2) Pub Date : 2025-05-21 Andrea Rosichini, Starla D. Glover
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Gut microbiota-mediated GPCR drug metabolism affects downstream pharmacological activity Nat. Chem. (IF 20.2) Pub Date : 2025-05-21 Amy K. Bracken, Pamela V. Chang
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Discovery of acylsulfenic acid-featuring natural product sulfenicin and characterization of its biosynthesis Nat. Chem. (IF 20.2) Pub Date : 2025-05-20 Dan Xue, Hongbin Zou, Yanping Qiu, Wei Lv, Michael D. Madden, Mingming Xu, Xiaoying Lian, Conor Pulliam, Ethan A. Older, Lukuan Hou, Andrew Campbell, Tristan de Rond, Takayoshi Awakawa, Chunhua Yuan, Bradley S. Moore, Jie Li
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A framework for evaluating the chemical knowledge and reasoning abilities of large language models against the expertise of chemists Nat. Chem. (IF 20.2) Pub Date : 2025-05-20 Adrian Mirza, Nawaf Alampara, Sreekanth Kunchapu, Martiño Ríos-García, Benedict Emoekabu, Aswanth Krishnan, Tanya Gupta, Mara Schilling-Wilhelmi, Macjonathan Okereke, Anagha Aneesh, Mehrdad Asgari, Juliane Eberhardt, Amir Mohammad Elahi, Hani M. Elbeheiry, María Victoria Gil, Christina Glaubitz, Maximilian Greiner, Caroline T. Holick, Tim Hoffmann, Abdelrahman Ibrahim, Lea C. Klepsch, Yannik Köster
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High-performance recyclable polymers enabled by stereo- and sequence-controlled polymerization Nat. Chem. (IF 20.2) Pub Date : 2025-05-16 Meng-Yuan Wang, Yi-Min Tu, Qing-Qian Zeng, Kun Li, Wei Xiong, Zhongzheng Cai, Jian-Bo Zhu
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Structural insights into two thiamine diphosphate-dependent enzymes and their synthetic applications in carbon–carbon linkage reactions Nat. Chem. (IF 20.2) Pub Date : 2025-05-14 Tan Liu, Guiyang Wang, Jiahui Yu, Mengyuan Li, Tianbo Peng, Jie Wang, Houhua Li, Xiao-dong Su, Changtao Jiang, Min Ye, Donghui Yang, Ming Ma
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Connecting the dots in a pH-dependent oxygen evolution reaction Nat. Chem. (IF 20.2) Pub Date : 2025-05-13 Thomas Götsch, Travis E. Jones, Detre Teschner
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Controlled anionic polymerization mediated by carbon dioxide Nat. Chem. (IF 20.2) Pub Date : 2025-05-13 Paige E. Jacky, Alexandra D. Easley, Brett P. Fors
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Exo-templating via pseudorotaxane formation reduces pathway complexity in the multicomponent self-assembly of M12L24 nanospheres Nat. Chem. (IF 20.2) Pub Date : 2025-05-12 T. Bouwens, E. O. Bobylev, L. S. D. Antony, D. A. Poole, E. Alarcón-Lladó, S. Mathew, J. N. H. Reek
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Shining light on flavin mononucleotide Nat. Chem. (IF 20.2) Pub Date : 2025-05-07 Qinglong Shi, Juntao Ye
Qinglong Shi and Juntao Ye discuss the history, structure, and reactivity of flavin mononucleotide in natural and non-natural reactions.
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Carnot batteries for dispatchable renewables Nat. Chem. (IF 20.2) Pub Date : 2025-05-07 Bruce C. Gibb
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Efficient and selective energy transfer photoenzymes powered by visible light Nat. Chem. (IF 20.2) Pub Date : 2025-05-06 Rebecca Crawshaw, Ross Smithson, Johannes Hofer, Florence J. Hardy, George W. Roberts, Jonathan S. Trimble, Anna R. Kohn, Colin W. Levy, Deborah A. Drost, Christian Merten, Derren J. Heyes, Richard Obexer, Thorsten Bach, Anthony P. Green
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Sharpening the lens of NMR spectroscopy to study large proteins Nat. Chem. (IF 20.2) Pub Date : 2025-05-05 Yun Huang, David Eliezer
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Leveraging relaxation-optimized 1H–13CF correlations in 4-19F-phenylalanine as atomic beacons for probing structure and dynamics of large proteins Nat. Chem. (IF 20.2) Pub Date : 2025-05-05 Andras Boeszoermenyi, Denitsa L. Radeva, Sebastian Schindler, Veronica Valadares, Krishna M. Padmanabha Das, Abhinav Dubey, Thibault Viennet, Max Schmitt, Peter Kast, Vladimir M. Gelev, Nikolay Stoyanov, Nikola Burdzhiev, Ognyan Petrov, Scott Ficarro, Jarred Marto, Ezekiel A. Geffken, Sirano Dhe-Paganon, Hyuk-Soo Seo, Nathan D. Alexander, Richard B. Cooley, Ryan A. Mehl, Helena Kovacs, Clemens Anklin
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Macrocyclic β-arch peptides that mimic the structure and function of disease-associated tau folds Nat. Chem. (IF 20.2) Pub Date : 2025-04-30 Isaac J. Angera, Xueyong Xu, Benjamin H. Rajewski, Grace I. Hallinan, Xiaoqi Zhang, Bernardino Ghetti, Ruben Vidal, Wen Jiang, Juan R. Del Valle
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Synthesis of zwitterionic open-shell bilayer spironanographenes Nat. Chem. (IF 20.2) Pub Date : 2025-04-30 Juan Lión-Villar, Jesús M. Fernández-García, Samara Medina Rivero, Josefina Perles, Shaofei Wu, Daniel Aranda, Jishan Wu, Shu Seki, Juan Casado, Nazario Martín
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Porous metal–organic polyhedra with a gecko’s grip Nat. Chem. (IF 20.2) Pub Date : 2025-04-24 Vincent Guillerm
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Transition-metal-free ammonia synthesis Nat. Chem. (IF 20.2) Pub Date : 2025-04-24 Yeqin Guan, Ping Chen
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Lanthanide–nickel molecular intermetallic complexes featuring a ligand-free Ni2− anion in endohedral fullerenes Nat. Chem. (IF 20.2) Pub Date : 2025-04-23 Panfeng Chuai, Ziqi Hu, Yang-Rong Yao, Zhanxin Jiang, Aman Ullah, Ya Zhao, Weiren Cheng, Muqing Chen, Eugenio Coronado, Shangfeng Yang, Zujin Shi
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Synthesis of strained, air-stable boracycles via boron–carbon-centred diradicals Nat. Chem. (IF 20.2) Pub Date : 2025-04-23 Xinmou Wang, Peiqi Zhang, Zhiyi Yang, Weixuan Sun, Hairong Lyu, Zhenyang Lin, Yangjian Quan
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4f-orbital covalency enables a single-crystal-to-single-crystal ring-opening isomerization in a CeIV–cyclopropenyl complex Nat. Chem. (IF 20.2) Pub Date : 2025-04-23 Brett D. Vincenzini, Xiaojuan Yu, Sébastien Paloc, Patrick W. Smith, Himanshu Gupta, Pragati Pandey, Greggory T. Kent, Osvaldo Ordonez, Taylor Keller, Michael R. Gau, Alexandra M. Bacon, Stefan G. Minasian, Trevor W. Hayton, Jochen Autschbach, Eric J. Schelter
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An enzymatic dual-oxa Diels–Alder reaction constructs the oxygen-bridged tricyclic acetal unit of (–)-anthrabenzoxocinone Nat. Chem. (IF 20.2) Pub Date : 2025-04-22 Xiaoli Yan, Xinying Jia, Zhenyao Luo, Shunjia Ji, Meng-Jie Zhang, Hui Zhang, Mingjia Yu, Julien Orts, Kai Jiang, Zhi Lin, Zixin Deng, Xu-Dong Kong, Bostjan Kobe, Yi-Lei Zhao, Mehdi Mobli, Xudong Qu
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Small-molecule-catalysed deamination enables transcriptome-wide profiling of N6-methyladenosine in RNA Nat. Chem. (IF 20.2) Pub Date : 2025-04-17 Pingluan Wang, Chang Ye, Michelle Zhao, Bochen Jiang, Chuan He
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Reactivity of syn-CH3CHOO with H2O enhanced through a roaming mechanism in the entrance channel Nat. Chem. (IF 20.2) Pub Date : 2025-04-16 Yiqiang Liu, Lijie Liu, Yanlin Fu, Haotian Jiang, Hao Wu, Yue Liu, Xiaoxiao Lu, Xiaohu Zhou, Hongwei Li, Rex T. Skodje, Xingan Wang, Bina Fu, Wenrui Dong, Dong H. Zhang, Xueming Yang