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Unexpected Ring Contraction of Homophthalic Anhydrides under Diazo Transfer Conditions Org. Lett. (IF 6.005) Pub Date : 2022-06-24 Alexander Kazantsev, Olga Bakulina, Dmitry Dar’in, Grigory Kantin, Alexander Bunev, Mikhail Krasavin
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Pocahemiketone A, a Sesquiterpenoid Possessing a Spirocyclic Skeleton with a Hemiketal Endoperoxide Unit, Alleviates Aβ25–35-Induced Pyroptosis and Oxidative Stress in SH-SY5Y Cells Org. Lett. (IF 6.005) Pub Date : 2022-06-24 Qin-Mei Zhou, Hao-Yu Zhao, Chuan Ma, Lu Huang, Jie Liu, Li Guo, Cheng Peng, Liang Xiong
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Synthesis of 2-Phospha[7]helicene, a Helicene with a Terminal Phosphinine Ring Org. Lett. (IF 6.005) Pub Date : 2022-06-24 Tomáš Beránek, Martin Jakubec, Jan Sýkora, Ivana Císařová, Jaroslav Žádný, Jan Storch
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Synthesis of Unnatural α-Amino Acid Derivatives via Photoredox Activation of Inert C(sp3)–H Bonds Org. Lett. (IF 6.005) Pub Date : 2022-06-24 Florence Babawale, Kathiravan Murugesan, Rok Narobe, Burkhard König
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Aspcandine: A Pyrrolobenzazepine Alkaloid Synthesized by a Fungal Nonribosomal Peptide Synthetase-Polyketide Synthase Hybrid Org. Lett. (IF 6.005) Pub Date : 2022-06-24 Lin Chen, Jian-Wei Tang, Yan Yee Liu, Yudai Matsuda
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Silver-Catalyzed Carbon Dioxide Fixation on Alkynylindoles Org. Lett. (IF 6.005) Pub Date : 2022-06-24 Seiya Uema, Kodai Saito, Tohru Yamada
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Palladium-Catalyzed Desulfonative Carbonylation of Thiosulfonates: Elimination of SO2 and Insertion of CO Org. Lett. (IF 6.005) Pub Date : 2022-06-23 Jian-Xing Xu, Le-Cheng Wang, Xiao-Feng Wu
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Weakly Coordinating tert-Amide-Assisted Ru(II)-Catalyzed Synthesis of Azacoumestans via Migratory Insertion of Quinoid Carbene: Application in the Total Synthesis of Isolamellarins Org. Lett. (IF 6.005) Pub Date : 2022-06-23 Souradip Sarkar, Rajarshi Samanta
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Thiocyanatoarylation of Methyl Vinyl Ketone under Meerwein Conditions for the Synthesis of 2-Aminothiazole-Based Heterocyclic Systems Org. Lett. (IF 6.005) Pub Date : 2022-06-23 Yurii V. Ostapiuk, Oksana V. Barabash, Mary Y. Ostapiuk, Evgeny Goreshnik, Mykola D. Obushak, Andreas Schmidt
4-Aryl-3-thiocyanatobutan-2-ones were prepared by Meerwein reactions from methyl vinyl ketone and aryldiazonium salts under copper(II) catalysis in 35–75% yields. α-Thiocyanato ketones regioselectively react with 1-methyl-3-aminopyrazole forming N-(3-pyrazolyl)-substituted 2-aminothiazoles in 80–91% yields. An ester group in position 3 of the pyrazole induced a regioselective ring-closure reaction
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Highly Substituted Acephenanthrylenes and Their π-Extended Derivatives: Syntheses, Structural Analyses, and Properties Org. Lett. (IF 6.005) Pub Date : 2022-06-23 Po-Ting Chen, Chia-Ling Yu, Min-Hsiu Shen, Mu-Jeng Cheng, Yao-Ting Wu, Hsiu-Fu Hsu
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Combinatorial Biosynthesis of Terpenoids through Mixing-and-Matching Sesquiterpene Cyclase and Cytochrome P450 Pairs Org. Lett. (IF 6.005) Pub Date : 2022-06-23 Man-Cheng Tang, Cheng Shen, Zixin Deng, Masao Ohashi, Yi Tang
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Homoallylboration of Aldehydes: Stereoselective Synthesis of Allylic-Substituted Alkenes and E-Alkenes Org. Lett. (IF 6.005) Pub Date : 2022-06-23 Daniel Polyak, Bokai Xu, Isaac J. Krauss
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A Mechanistic Switch from Homoallylation to Cyclopropylcarbinylation of Aldehydes Org. Lett. (IF 6.005) Pub Date : 2022-06-23 Woojin Lee, Daniel Polyak, Bokai Xu, K. N. Houk, Isaac J. Krauss
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Catalytic Enantioselective Reductive Cross Coupling of Electron-Deficient Olefins Org. Lett. (IF 6.005) Pub Date : 2022-06-23 Kangning Cao, Chunyang Li, Dong Tian, Xiaowei Zhao, Yanli Yin, Zhiyong Jiang
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Correction to “Synthetic Studies toward DNA-Encoded Heterocycles Based on the On-DNA Formation of α, β-Unsaturated Ketones” Org. Lett. (IF 6.005) Pub Date : 2022-06-23 Sixiu Liu, Jingjing Qi, Weiwei Lu, Xuan Wang, Xiaojie Lu
The affiliation of the corresponding author Xiaojie Lu was incorrect. Previously published affiliation: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Zhang Jiang Hi-Tech Park, Pudong, Shang-hai, 201203, China Corrected affiliation: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy
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Stereoselective Access to Iminosugar C,C-Glycosides from 6-Azidoketopyranoses Org. Lett. (IF 6.005) Pub Date : 2022-06-22 Zakaria Debbah, Jérôme Marrot, Nicolas Auberger, Jérôme Désiré, Yves Blériot
We report the synthesis of iminosugar C,C-glycosides starting from 6-azidoketopyranoses. Their Staudinger-azaWittig-mediated cyclization provided bicyclic N,O-acetals, which were stereoselectively opened with AllMgBr to afford β-hydroxyazepanes with a quaternary carbon α to the nitrogen. Their ring contraction via a β-aminoalcohol rearrangement produced the six-membered l-iminosugars with two functional
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Palladium-Catalyzed Regioselective [5 + 1] Annulation of Vinyl Aziridines/Epoxides with ClCF2COONa Org. Lett. (IF 6.005) Pub Date : 2022-06-22 Dandan Zuo, Tao Zhang, Jingjing Zhao, Wen Luo, Chaojie Wang, Pan Li
Palladium-catalyzed regioselective [5 + 1] annulation reactions of vinyl aziridines/epoxides with ClCF2COONa have been developed. Significantly, vinyl aziridines/epoxides act as heteroatom-containing five-atom synthons, and commercially available and cheap ClCF2COONa acts as the source of carbonyl serving as a difluorocarbene precursor. This protocol provides an efficient and practical method for the
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Synthesis, Characterization, and Properties of BN-Fluoranthenes Org. Lett. (IF 6.005) Pub Date : 2022-06-22 Erlong Li, Mengjia Jin, Ruijun Jiang, Lei Zhang, Yanli Zhang, Meiyan Liu, Xiaoming Wu, Xuguang Liu
Boron/nitrogen-doped fluoranthenes, a new class of BN-doped cyclopenta-fused polycyclic aromatic hydrocarbons, were synthesized via pyrrolic-type nitrogen directed C–H borylation. Regioselective bromination of BN-fluoranthene (3a) gave mono- and dibrominated BN-fluoranthenes. The halogenated BN-fluoranthene (3b) can undergo various of further cross-coupling reactions to deliver a series of BN-fluoranthenes
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Attached Nitrogen Test by 13C–14N Solid-State NMR Spectroscopy for the Structure Determination of Heterocyclic Isomers Org. Lett. (IF 6.005) Pub Date : 2022-06-22 Rick W. Dorn, Brendan J. Wall, Sarah B. Ference, Sean R. Norris, Joseph W. Lubach, Aaron J. Rossini, Brett VanVeller
Differentiation of heterocyclic isomers by solution 1H, 13C, and 15N NMR spectroscopy is often challenging due to similarities in their spectroscopic signatures. Here, 13C{14N} solid-state NMR spectroscopy experiments are shown to operate as an “attached nitrogen test”, where heterocyclic isomers are easy to distinguish based on one-dimensional nitrogen-filtered 13C solid-state NMR. We anticipate that
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Synthesis and Spectral Properties of Aggregation-Induced Emission-Active Push–Pull Chromophores Based On Isoindole Scaffolds Org. Lett. (IF 6.005) Pub Date : 2022-06-22 Changjiang Yu, Xingbao Fang, Qinghua Wu, Xing Guo, Na Chen, Chao Cheng, Erhong Hao, Lijuan Jiao
A new class of tailor-made push–pull isoindole fluorophores has been synthesized through the combination of Suzuki coupling and Knoevenagel reactions. The efficient synthetic strategy rendered the isoindole scaffold as the π-bridge and the isolation spacer and provided dyes bearing various types of electron donors and electron acceptors for manipulating their energy gaps and tuning their absorptions
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Construction of N-Polyheterocycles by N-Heterocyclic Carbene Catalysis via a Regioselective Intramolecular Radical Addition/Cyclization Cascade Org. Lett. (IF 6.005) Pub Date : 2022-06-22 Qijing Zhang, Hao Lei, Cong-Ying Zhou, Chengming Wang
N-Polyheterocycles are rapidly accessed by N-heterocyclic carbene (NHC) catalysis through regioselective sequential radical addition/cyclization in the absence of any metals or oxidants. The transformation occurs under mild conditions and enjoys a wide substrate scope with excellent functional group compatibility. Furthermore, a gram-scale synthesis is also conducted. Preliminary mechanistic studies
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Syn-Stereoselective C3-Spirocyclization and C2-Amination of 3-(2-Isocyanoethyl)indole Using C,N-Cyclic Azomethine Imines Org. Lett. (IF 6.005) Pub Date : 2022-06-22 Wen-Bin Cao, Jian-Dong Zhang, Meng-Meng Xu, Hua-Wei Liu, Hai-Yan Li, Xiao-Ping Xu, Shun-Jun Ji
By utilizing an underexplored reaction mode of C,N-cyclic azomethine imines, a catalyst-free [1+2+3] cycloaddition/N–N bond cleavage sequential reaction for accessing spiroindolines with syn-stereoselectivity was developed. On the basis of experimental results and DFT calculations, peroxide and ethereal solvent were identified to trigger the hydrogen abstraction of the unstable [1+2+3] cycloaddition
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Atroposelective Synthesis of Axially Chiral C2-Arylindoles via Rhodium-Catalyzed Asymmetric C–H Bond Insertion Org. Lett. (IF 6.005) Pub Date : 2022-06-22 Junheng Liu, Qiongya Li, Ying Shao, Jiangtao Sun
A highly efficient rhodium-catalyzed formal C–H insertion reaction between indoles and 1-diazonaphthoquinones has been established, providing a novel protocol for the atroposelective synthesis of axially chiral C2-arylindoles (up to 99:1 er) under mild reaction conditions. Typically, only 1 mol % of Rh2(S-PTTL)4 is used and the chelation group is not needed for this conversion.
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Visible-Light-Induced Copper-Catalyzed Asymmetric C(sp3)–C(sp3)–H Glycosylation: Access to C-Glycopeptides Org. Lett. (IF 6.005) Pub Date : 2022-06-21 Ya-Nan Ding, Ning Li, Yan-Chong Huang, Yang An, Yong-Min Liang
Herein, a practical and highly efficient method for visible-light-induced copper-catalyzed N-aminoquinoline-directed asymmetric C(sp3)–C(sp3)–H glycosylation was reported. At the same time, C(sp3)–C(sp3)–H glycosylation of nondeoxysugars with amino acids to construct C-glycopeptides was achieved. This approach promoted the synthesis of various C-glycopeptides and provided a new model for the synthesis
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Catalyst-Controlled, Site-Selective Sulfamoylation of Carbohydrate Derivatives Org. Lett. (IF 6.005) Pub Date : 2022-06-21 Daniel J. Gorelik, Julia A. Turner, Mark S. Taylor
Methods for site-selective sulfamoylation of secondary hydroxyl groups in pyranosides are described. Using a boronic acid catalyst, selective installation of a Boc-protected sulfamoyl group at the equatorial position of cis-diols in manno- and galacto-configured substrates has been achieved. Activation of trans-diol groups in gluco- and galacto-configured substrates is also possible by employing an
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Photoinduced C(sp3)–H Chalcogenation of Amide Derivatives and Ethers via Ligand-to-Metal Charge-Transfer Org. Lett. (IF 6.005) Pub Date : 2022-06-21 Ben Niu, Krishnakumar Sachidanandan, Maria Victoria Cooke, Taylor E. Casey, Sébastien Laulhé
A photoinduced, iron(III) chloride-catalyzed C–H activation of N-methyl amides and ethers leads to the formation of C–S and C–Se bonds via a ligand-to-metal charge transfer (LMCT) process. This methodology converts secondary and tertiary amides, sulfonamides, and carbamates into the corresponding amido-N,S-acetal derivatives in good yields. Mechanistic work revealed that this transformation proceeds
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Electricity Induced Rhodium-Catalyzed Oxidative C–H/N–H Annulation of Alkynes with Arylhydrophthalazinediones Org. Lett. (IF 6.005) Pub Date : 2022-06-21 Partha Pratim Sen, Rashmi Prakash, Sudipta Raha Roy
The development of stoichiometric oxidant-free regioselective annulation protocol is a challenging aspect in organic synthesis. Herein, we disclose electricity as a greener oxidant for the C–H/N–H annulation to construct cinnolines using rhodium(III) catalyst under mild conditions. A detailed mechanistic investigation revealed the possibility of both Rh(III/I) and Rh(III/IV) catalytic cycles for the
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Cobalt-Catalyzed Migration Isomerization of Dienes Org. Lett. (IF 6.005) Pub Date : 2022-06-21 Jiajin Zhao, Guoxiong Xu, Xue Wang, Jiren Liu, Xiang Ren, Xin Hong, Zhan Lu
A cobalt-catalyzed multipositional isomerization of conjugated dienes has been reported for the first time using an 8-oxazoline iminoquinoline ligand. This reaction is operationally simple and atom-economical using readily available starting materials with an E/Z mixture to access disubstituted 1,3-dienes with excellent yields and good E,E stereoselectivity. The mechanism via alkene insertion of cobalt
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Visible-Light-Promoted Cross-Coupling of O-Aryl Oximes and Nitrostyrenes to Access Cyanoalkylated Alkenes Org. Lett. (IF 6.005) Pub Date : 2022-06-21 Jie Gao, Zhi-Peng Ye, Yu-Fei Liu, Xian-Chen He, Jian-Ping Guan, Fang Liu, Kai Chen, Hao-Yue Xiang, Xiao-Qing Chen, Hua Yang
A photoinduced, photocatalyst-free cyanoalkylation of nitrostyenes was explored, affording a series of cyanoalkylated alkenes in moderate to good yields. Mechanistic studies reveal that an electron donor–acceptor complex formed between O-aryl oximes and DIPEA is presumably involved in this process. The excellent functional group compatibility of this newly designed synthetic protocol allows for cyanoalkylation
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Electrosynthesis of Stabilized Diazo Compounds from Hydrazones Org. Lett. (IF 6.005) Pub Date : 2022-06-21 Nour Tanbouza, Alessia Petti, Matthew C. Leech, Laurent Caron, Jamie M. Walsh, Kevin Lam, Thierry Ollevier
An electrochemical synthesis of diazo compounds from hydrazones in yields as high as 99% was performed. This method was elaborated as a useful synthetic method and demonstrated on various diazo compounds (24 examples). Apart from exhibiting an efficiency that matched that of commonly used harsh and toxic chemical oxidants, this reaction is practically simple to set up, requires mild conditions, and
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Enantioselective Friedel–Crafts Alkylation Reaction of Pyrroles with N-Unprotected Alkynyl Trifluoromethyl Ketimines Org. Lett. (IF 6.005) Pub Date : 2022-06-21 Tatsuhiro Uchikura, Kureha Aruga, Riku Suzuki, Takahiko Akiyama
Developed herein is an enantioselective Friedel–Crafts alkylation reaction of N-unprotected alkynyl trifluoromethyl ketimines with pyrroles catalyzed by chiral phosphoric acid to furnish chiral primary α-trifluoromethyl-α-(2-pyrrolyl)propargylamines with high enantioselectivity. Transformation of the alkynyl group of the adducts afforded optically active α-trifluoromethylated amines bearing various
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Palladium Metallaphotoredox-Catalyzed 2-Arylation of Indole Derivatives Org. Lett. (IF 6.005) Pub Date : 2022-06-21 Xinmou Wang, Xiwei Xun, Hongjian Song, Yuxiu Liu, Qingmin Wang
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Radical Multicomponent Alkyl Alkynylation of Propellane via Synergistic Photoredox and Copper Catalysis Org. Lett. (IF 6.005) Pub Date : 2022-06-21 Jie Shi, Qiao-Lin Xu, Yu-Qing Ni, Lin Li, Fei Pan
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Dibenzocyclooctendiones (DBCDOs): Arginine-Selective Chemical Labeling Reagents Obtained through Benzilic Acid Rearrangement Org. Lett. (IF 6.005) Pub Date : 2022-06-21 Cheng-Ting Shih, Bo-Hong Kuo, Chun-Yi Tsai, Mei-Chun Tseng, Jiun-Jie Shie
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Lycojapomines A–E: Lycopodium Alkaloids with Anti-Renal Fibrosis Potential from Lycopodium japonicum Org. Lett. (IF 6.005) Pub Date : 2022-06-20 Dan Xia, Zi-Han Wang, Jia-Meng Jiang, Xue-Wen Yang, Yue Gao, Yin-Ying Xu, Lin-Yue Chang, Dan Zhu, Bao-Jun Zhao, Xin-Liu Zhu, Jian Zhang, Zhi-Qi Yin, Ke Pan
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Undirected, Asymmetric Alkyl Group Functionalizations through Alkane Dehydrogenation Org. Lett. (IF 6.005) Pub Date : 2022-06-20 Feng Yu, Renqing Tao, Yiting Su, Guixia Liu, Zheng Huang
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Asymmetric Cycloadditions of Acyclic Carbonyl Ylides with Aldehydes Catalyzed by a Chiral Binaphthyldiimine-Ni(II) Complex: Enantioselective Synthesis of 1,3-Dioxolanes and Mechanistic Studies by DFT Calculations Org. Lett. (IF 6.005) Pub Date : 2022-06-20 Yasunori Toda, Kayo Sato, Kensuke Sato, Kazuma Nagasaki, Hirotaka Nakajima, Ayaka Kikuchi, Kimiya Sukegawa, Hiroyuki Suga
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Simultaneous Construction of C–N Axial and Central Chirality via Silver-Catalyzed Desymmetrizative [3 + 2] Cycloaddition of Prochiral N-Aryl Maleimides with Activated Isocyanides Org. Lett. (IF 6.005) Pub Date : 2022-06-20 Sen Zhang, Zhang-Hong Luo, Wen-Tao Wang, Linghui Qian, Jia-Yu Liao
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Visible-Light-Catalyzed Tandem Radical Addition/1,5-Hydrogen Atom Transfer/Cyclization of 2-Alkynylarylethers with Sulfonyl Chlorides Org. Lett. (IF 6.005) Pub Date : 2022-06-20 Long Li, Jiao-Zhe Li, Yong-Bin Sun, Chun-Mei Luo, Hui Qiu, Keqi Tang, Hongxin Liu, Wen-Ting Wei
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Unified Total Synthesis of Diverse Meroterpenoids from Ganoderma Applanatum Org. Lett. (IF 6.005) Pub Date : 2022-06-19 Michal Šimek, Kateřina Bártová, Samy Issad, Miroslav Hájek, Ivana Císařová, Ullrich Jahn
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Aminooxy Click Chemistry as a Tool for Bis-homo and Bis-hetero Ligand Conjugation to Nucleic Acids Org. Lett. (IF 6.005) Pub Date : 2022-06-17 Dhrubajyoti Datta, Shohei Mori, Mimouna Madaoui, Kelly Wassarman, Ivan Zlatev, Muthiah Manoharan
An aminooxy click chemistry (AOCC) strategy was used to synthesize nucleoside building blocks for incorporation during solid-support synthesis of oligonucleotides to enable bis-homo and bis-hetero conjugation of various biologically relevant ligands. The bis-homo aminooxy conjugation leads to bivalent ligand presentation, whereas the bis-hetero conjugation allows the placement of different ligands
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Gold(I)-Catalyzed Selective Hydroarylation of Indoles with Haloalkynes Org. Lett. (IF 6.005) Pub Date : 2022-06-17 Cunbo Wei, Jiawen Wu, Lizhu Zhang, Zhonghua Xia
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Silver-Catalyzed Controlled Intermolecular Cross-Coupling of Silyl Enol Ethers: Scalable Access to 1,4-Diketones Org. Lett. (IF 6.005) Pub Date : 2022-06-17 Li Xu, Xiaoyi Liu, Gregory R. Alvey, Andrey Shatskiy, Jian-Quan Liu, Markus D. Kärkäs, Xiang-Shan Wang
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Isolation of Caldorazole, a Thiazole-Containing Polyketide with Selective Cytotoxicity under Glucose-Restricted Conditions Org. Lett. (IF 6.005) Pub Date : 2022-06-17 Osamu Ohno, Arihiro Iwasaki, Kyouhei Same, Chihiro Kudo, Erika Aida, Kazuya Sugiura, Shimpei Sumimoto, Toshiaki Teruya, Etsu Tashiro, Siro Simizu, Kenji Matsuno, Masaya Imoto, Kiyotake Suenaga
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Copper-Catalyzed 6-endo-dig Cyclization–Coupling of 2-Bromoaryl Ketones and Terminal Alkynes toward Naphthyl Aryl Ethers in Water Org. Lett. (IF 6.005) Pub Date : 2022-06-17 Lebin Su, Shimin Xie, Jianyu Dong, Neng Pan, Shuang-Feng Yin, Yongbo Zhou
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CuH-Catalyzed Enantioselective Reductive Coupling of 1,3-Dienes and Trifluoromethyl Ketoimines or α-Iminoacetates Org. Lett. (IF 6.005) Pub Date : 2022-06-17 Xue-Hua Deng, Jia-Xi Jiang, Qin Jiang, Ting Yang, Bo Chen, Long He, Wen-Dao Chu, Cheng-Yu He, Quan-Zhong Liu
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Chan–Lam Reaction and Lewis Acid Promoted 1,3-Rearrangement of N–O Bonds to Prepare N-(2-Hydroxyaryl)pyridin-2-ones Org. Lett. (IF 6.005) Pub Date : 2022-06-17 Hong-Yan Bi, Qing-Yan Wu, Xiao-Mei Zhou, Hui-Juan Xu, Cui Liang, Dong-Liang Mo, Xiao-Pan Ma
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Isolation and Total Synthesis of Beru’amide, an Antitrypanosomal Polyketide from a Marine Cyanobacterium Okeania sp. Org. Lett. (IF 6.005) Pub Date : 2022-06-17 Raimu Taguchi, Arihiro Iwasaki, Akira Ebihara, Ghulam Jeelani, Tomoyoshi Nozaki, Kiyotake Suenaga
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N-Heterocyclic Nitreniums Can Be Employed as Photoredox Catalysts for the Single-Electron Reduction of Aryl Halides Org. Lett. (IF 6.005) Pub Date : 2022-06-16 Kun-Quan Chen, Bei-Bei Zhang, Zhi-Xiang Wang, Xiang-Yu Chen
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Synthetic Approach toward Enantiopure Cyclic Sulfinamides Org. Lett. (IF 6.005) Pub Date : 2022-06-16 Glebs Jersovs, Matiss Bojars, Pavel A. Donets, Edgars Suna
A synthetic approach toward densely substituted enantiopure cyclic sulfinamides possessing up to four consecutive stereogenic centers was developed based on a completely diastereoselective SN2′ cyclization/tert-Bu cleavage sequence. Diastereospecific transformation of the obtained scaffold into chiral SVI derivatives such as sulfoximines and sulfonimidamides is demonstrated.
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A Heterogeneous Iridium Catalyst for the Hydroboration of Pyridines Org. Lett. (IF 6.005) Pub Date : 2022-06-16 Jessica Rodriguez, Matthew P. Conley
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Correction to “Access to Cyclopropyl-Fused Azacycles via a Palladium-Catalyzed Direct Alkenylation Strategy” Org. Lett. (IF 6.005) Pub Date : 2022-06-16 Carolyn L. Ladd, André B. Charette
The structure of 2l in Scheme 4 has been misassigned and it should be drawn as follows: The structure 2l on page S20 of the Supporting Information should also be drawn as above. The name should be replaced with 2-Methyl-2,5,6,7,8,9-hexahydro-1H-benzo[c]azepin-1-one (2l) The spectroscopic data in the Supporting Information are correct, and this finding does not impact on the conclusions of the paper
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Regioselective Cycloaddition and Substitution Reaction of Tertiary Propargylic Alcohols and Heteroareneboronic Acids via Acid Catalysis Org. Lett. (IF 6.005) Pub Date : 2022-06-15 Jian-Fei Bai, Jianbo Tang, Xiaolong Gao, Zhi-Jiang Jiang, Bencan Tang, Jia Chen, Zhanghua Gao
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A Formal (4 + 2) Cycloaddition of Phosphorus Ylides: Synthesis of Aromatic and Heteroaromatic 1,2-Diesters and Diones Org. Lett. (IF 6.005) Pub Date : 2022-06-15 Palani Manikandan, Rudrasenan Agneswaran, Vinayagam Pavunkumar, Arasambattu K. Mohanakrishnan
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Copper-Catalyzed Umpolung of N-2,2,2-Trifluoroethylisatin Ketimines for the Enantioselective 1,3-Dipolar Cycloaddition with Benzo[b]thiophene Sulfones Org. Lett. (IF 6.005) Pub Date : 2022-06-15 Wei-Cheng Yuan, Lei Yang, Jian-Qiang Zhao, Hong-Yan Du, Zhen-Hua Wang, Yong You, Yan-Ping Zhang, Jiabin Liu, Wenjing Zhang, Ming-Qiang Zhou
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Total Synthesis of a PPAP, Nemorosonol, Using a Tandem Michael Addition–Intramolecular Aldol Reaction Org. Lett. (IF 6.005) Pub Date : 2022-06-15 Keisuke Mitsugi, Toru Takabayashi, Takayuki Ohyoshi, Hideo Kigoshi
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Cobalt(II)-Catalyzed C–H and N–H Functionalization of 1-Arylpyrazolidinones with Dioxazolones as Bifunctional Synthons Org. Lett. (IF 6.005) Pub Date : 2022-06-15 Xiliang Han, Chao Pi, Di Hu, Wei Hu, Yangjie Wu, Xiuling Cui
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Regio- and Stereoselective Electrochemical Alkylation of Morita–Baylis–Hillman Adducts Org. Lett. (IF 6.005) Pub Date : 2022-06-14 Giulio Bertuzzi, Giada Ombrosi, Marco Bandini
Electrosynthesis is effectively employed in a general regio- and stereoselective alkylation of Morita–Baylis–Hillman compounds. The exposition of N-acyloxyphthalimides (redox-active esters) to galvanostatic electroreductive conditions, following the sacrificial-anode strategy, is proved an efficient and practical method to access densely functionalized cinnamate and oxindole derivatives. High yields
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Total Synthesis of Pentaketide Ansamycin Microansamycin H Org. Lett. (IF 6.005) Pub Date : 2022-06-14 Satapanawat Sittihan, Somsak Ruchirawat
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A One-Pot Photochemical Method for the Generation of Functionalized Aminocyclopentanes Org. Lett. (IF 6.005) Pub Date : 2022-06-14 James L. Collins III, Daryl Staveness, Madison J. Sowden, Corey R. J. Stephenson