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Progress on the mechanism of natural products alleviating androgenetic alopecia Eur. J. Med. Chem. (IF 6.7) Pub Date : 2023-12-06 Shuqi Wu, Xiaohong Kou, Yujia Niu, Yazhou Liu, Bowen Zheng, Juan Ma, Mengyi Liu, Zhaohui Xue
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Biological evaluation of carbohydrate-based aprepitant analogs for neuroblastoma treatment Eur. J. Med. Chem. (IF 6.7) Pub Date : 2023-12-05 Victoria Valdivia, Rocío Recio, Patricia Lerena, Esther Pozo, Rosario Serrano, Raúl Calero, Cristina Pintado, Manuel Pernia Leal, Nazaret Moreno-Rodríguez, Juan Ángel Organero, Noureddine Khiar, Inmaculada Fernández
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Novel antimicrobial peptides modified with fluorinated sulfono-γ-AA having high stability and targeting multidrug-resistant bacteria infections Eur. J. Med. Chem. (IF 6.7) Pub Date : 2023-12-02 Xiaomin Guo, Xiaokang Miao, Yingying An, Tiantian Yan, Yue Jia, Bochuan Deng, Jianfeng Cai, Wenle Yang, Wangsheng Sun, Rui Wang, Junqiu Xie
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Targeting the pyruvate dehydrogenase complex/pyruvate dehydrogenase kinase (PDC/PDK) axis to discover potent PDK inhibitors through structure-based virtual screening and pharmacological evaluation Eur. J. Med. Chem. (IF 6.7) Pub Date : 2023-12-03 Linling Gan, Ying Yang, Zizhen Liang, Maojie Zhang, Yun He, Shao-Lin Zhang
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Discovery and exploration of novel somatostatin receptor subtype 5 (SSTR5) antagonists for the treatment of cholesterol gallstones Eur. J. Med. Chem. (IF 6.7) Pub Date : 2023-12-05 Fanghui Han, Tingting Zhao, Yanglong Zhang, Ying Yun, Yuanyuan Xu, Shimeng Guo, Yongqing Zhong, Xin Xie, Jianhua Shen
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Structure-based design of SARS-CoV-2 papain-like protease inhibitors Eur. J. Med. Chem. (IF 6.7) Pub Date : 2023-12-05 Prakash Jadhav, Bo Huang, Jerzy Osipiuk, Xiaoming Zhang, Haozhou Tan, Christine Tesar, Michael Endres, Robert Jedrzejczak, Bin Tan, Xufang Deng, Andrzej Joachimiak, Jianfeng Cai, Jun Wang
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Design, synthesis and evaluation of novel deferasirox derivatives with high antifungal potency in vitro and in vivo Eur. J. Med. Chem. (IF 6.7) Pub Date : 2023-12-04 Tingjunhong Ni, Xiaochen Chi, Hao Wu, Fei Xie, Junhe Bao, Jiayin Wang, Zhe Ji, Liping Li, Xiaobo Wang, Lan Yan, Yumeng Hao, Dazhi Zhang, Yuanying Jiang
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Synthesis and antimicrobial properties of guanidine-functionalized labdane type diterpenoids Eur. J. Med. Chem. (IF 6.7) Pub Date : 2023-12-04 Marina Grinco, Olga Morarescu, Francesca Lembo, Nicon Ungur, Luigia Turco, Lorena Coretti, Marianna Carbone, Carmela Celentano, Maria Letizia Ciavatta, Ernesto Mollo, Veaceslav Kulcitki, Elisabetta Buommino
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Membrane-permeable tenofovir-di- and monophosphate analogues Eur. J. Med. Chem. (IF 6.7) Pub Date : 2023-12-04 Xiao Jia, Giuliano A. Kullik, Marianna Bufano, Andrea Brancale, Dominique Schols, Chris Meier
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Whole cell hydride Meisenheimer complex biotransformation guided optimization of antimycobacterial benzothiazinones Eur. J. Med. Chem. (IF 6.7) Pub Date : 2023-12-03 Melanie Joch, K. Philip Wojtas, Héctor Torres-Gómez, Yan Li, Florian Meyer, Maria Straßburger, Valerie Kerndl, Hans-Martin Dahse, Christian Hertweck, Harald Hoffmann, Helmar Görls, Kerstin Walter, Christoph Hölscher, Florian Kloss
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Synthesis of melampomagnolide B derivatives as potential anti-Triple Negative Breast Cancer agents Eur. J. Med. Chem. (IF 6.7) Pub Date : 2023-12-03 Tianyang Chen, Xiaoping Chen, Lingling Liu, Quan Zhang, Yahui Ding
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Recent progress and applications of small molecule inhibitors of Keap1–Nrf2 axis for neurodegenerative diseases Eur. J. Med. Chem. (IF 6.7) Pub Date : 2023-11-29 Jing Wang, Yu Cao, Yang Lu, Huajian Zhu, Jiankang Zhang, Jinxin Che, Rangxiao Zhuang, Jiaan Shao
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Exploring the potential of histone demethylase inhibition in multi-therapeutic approaches for cancer treatment Eur. J. Med. Chem. (IF 6.7) Pub Date : 2023-11-29 Deping Li, Hailiu Liang, Yifei Wei, Hao Xiao, Xiaopeng Peng, Wanyi Pan
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Rational design and optimization of novel 4-methyl quinazoline derivatives as PI3K/HDAC dual inhibitors with benzamide as zinc binding moiety for the treatment of acute myeloid leukemia Eur. J. Med. Chem. (IF 6.7) Pub Date : 2023-11-30 Kehui Zhang, Rui Huang, Ming Ji, Songwen Lin, Fangfang Lai, Deyu Wu, Hua Tian, Jinhui Bi, Shouguo Peng, Jiaqi Hu, Li Sheng, Yan Li, Xiaoguang Chen, Heng Xu
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Mitochondrial targeting derivatives of honokiol enhanced selective antitumor activity in NCI–H446 cells and decreased in vivo toxicity in Caenorhabditis elegans Eur. J. Med. Chem. (IF 6.7) Pub Date : 2023-12-03 Huicong Miao, Wenbo Cui, Tao Zhang, Yue Zhang, Jiaozhen Zhang, Hongxiang Lou, Peihong Fan
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Targeting PIM kinases in cancer therapy: An update on pharmacological small-molecule inhibitors Eur. J. Med. Chem. (IF 6.7) Pub Date : 2023-12-02 Siwei Chen, Yushang Yang, Yong Yuan
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M335, a novel small-molecule STING agonist activates the immune response and exerts antitumor effects Eur. J. Med. Chem. (IF 6.7) Pub Date : 2023-12-02 Man Zhao, Weizhen Fan, Ying Wang, Pengfei Qiang, Zhihua Zheng, Hao Shan, Ming Zhang, Pengyutian Liu, Yao Wang, Guofeng Li, Min Li, Liang Hong
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Identification of a novel potent CDK inhibitor degrading cyclinK with a superb activity to reverse trastuzumab-resistance in HER2-positive breast cancer in vivo Eur. J. Med. Chem. (IF 6.7) Pub Date : 2023-12-01 Ratnakar Reddy Kuchukulla, Injeoung Hwang, Suhn Hyung Kim, Younghyeon Kye, Narae Park, Heary Cha, Sojeong Moon, Hwan Won Chung, Cheolju Lee, Gu Kong, Wooyoung Hur
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Investigating the anti-cancer potential of pyrimethamine analogues through a modern chemical biology lens Eur. J. Med. Chem. (IF 6.7) Pub Date : 2023-11-29 Jennifer I. Brown, Rosanne Persaud, Petar Iliev, Ujjwala Karmacharya, Sanaz Attarha, Henok Sahile, Jonas Olsen, Danielle Hanke, Temilolu Idowu, David A. Frank, Adam Frankel, Karla C. Williams, Brent D.G. Page
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Promises of anionic calix[n]arenes in life science: State of the art in 2023 Eur. J. Med. Chem. (IF 6.7) Pub Date : 2023-11-30 Adina-N. Lazar, Florent Perret, Marta Perez-Lloret, Mickael Michaud, Anthony W. Coleman
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Plant-derived strategies to fight against severe acute respiratory syndrome coronavirus 2 Eur. J. Med. Chem. (IF 6.7) Pub Date : 2023-11-30 Wenkang Li, Tianze Ding, Huimin Chang, Yuanchang Peng, Jun Li, Xin Liang, Huixin Ma, Fuguang Li, Maozhi Ren, Wang Wenjing
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Synthesis and biological evaluation of Ribo 7-N/O/S pyrimidine 9-deaza C-nucleoside analogs as new antiviral agents for inhibiting HCV RNA-dependent RNA polymerases Eur. J. Med. Chem. (IF 6.7) Pub Date : 2023-11-29 Minwan Wu, Satish Vadlakonda, Yahya El-Kattan, Ajit Ghosh, Tsu-Hsing Lin, Ramanda Chambers-Wilson, Xiaogang Cheng, Shanta Bantia, Debra Kellogg-Yelder, Pooran Chand, Y.S. Babu, Pravin L. Kotian
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Design and synthesis of dual BRD4/Src inhibitors for treatment of triple-negative breast cancer Eur. J. Med. Chem. (IF 6.7) Pub Date : 2023-11-29 Ying Wang, Aima Huang, Lu Chen, Fan Sun, Man Zhao, Ming Zhang, Yubao Xie, Shiyu Xu, Min Li, Liang Hong, Guofeng Li, Rui Wang
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Design, synthesis, and evaluation of 5,15-diaryltetranaphtho [2,3]porphyrins as photosensitizers in real-time photodynamic therapy and photodiagnosis Eur. J. Med. Chem. (IF 6.7) Pub Date : 2023-11-25 Tao Xu, Le Mi, Tabbisa Namulinda, Danye Chen, Yi-Jia Yan, Zhi-Long Chen
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Design, synthesis and biological evaluation of the positional isomers of the galactose conjugates able to target hepatocellular carcinoma cells via ASGPR-mediated cellular uptake and cytotoxicity Eur. J. Med. Chem. (IF 6.7) Pub Date : 2023-11-25 Wenchong Ye, Qun Tang, Tiantian Zhou, Cui Zhou, Chuangchuang Fan, Xiaoyang Wang, Chunmei Wang, Keyu Zhang, Guochao Liao, Wen Zhou
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Benzothiozinone derivatives with anti-tubercular Activity−Further side chain investigation Eur. J. Med. Chem. (IF 6.7) Pub Date : 2023-11-25 Xiaomei Wu, Wenxin Wang, Giovanni Stelitano, Olga Riabova, Bin Wang, Wei Niu, Mario Cocorullo, Rui Shi, Laurent R. Chiarelli, Vadim Makarov, Yu Lu, Chuan Li, Chunhua Qiao
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Blood-stage antimalarial activity, favourable metabolic stability and in vivo toxicity of novel piperazine linked 7-chloroquinoline-triazole conjugates Eur. J. Med. Chem. (IF 6.7) Pub Date : 2023-11-25 Amad Uddin, Sonal Gupta, Rumaisha Shoaib, Babita Aneja, Iram Irfan, Kanika Gupta, Neha Rawat, Jill Combrinck, Bhumika Kumar, Mohd Aleem, Phool Hasan, Mukesh C. Joshi, Yashpal S. Chhonker, Muhammad Zahid, Afzal Hussain, Kailash Pandey, Mohamed F. Alajmi, Daryl J. Murry, Timothy J. Egan, Shailja Singh, Mohammad Abid
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Synthesis and preclinical evaluation of novel 18F-labeled fibroblast activation protein tracers for positron emission tomography imaging of cancer-associated fibroblasts Eur. J. Med. Chem. (IF 6.7) Pub Date : 2023-11-25 Hui Zhou, Jiawei Zhong, Simin Peng, Yang Liu, Peipei Tang, Zhikai Cai, Lu Wang, Hao Xu, Kongzhen Hu
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Synthesis and evaluation of novel meso-substitutedphenyl dithieno[3,2-b]thiophene-fused BODIPY derivatives as efficient photosensitizers for photodynamic therapy Eur. J. Med. Chem. (IF 6.7) Pub Date : 2023-11-30 Ning Cao, Ying Jiang, Zhi-Bing Song, Danye Chen, Dan Wu, Zhi-Long Chen, Yi-Jia Yan
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Discovery of novel deoxyvasicinone derivatives with benzenesulfonamide substituents as multifunctional agents against Alzheimer's disease Eur. J. Med. Chem. (IF 6.7) Pub Date : 2023-11-30 Shuanghong Dong, Jucheng Xia, Fang Wang, Lili Yang, Siqi Xing, Jiyu Du, Tingting Zhang, Zeng Li
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Design, synthesis, and biological evaluation of 2-amino-6-methyl-phenol derivatives targeting lipid peroxidation with potent anti-ferroptotic activities Eur. J. Med. Chem. (IF 6.7) Pub Date : 2023-11-28 Xie-Huang Sheng, Li-Cong Han, Xiao-Jie Ma, Ao Gong, Meng-Zhu Hao, Hao Zhu, Xiang-Shuai Meng, Ting Wang, Chang-Hua Sun, Jian-Ping Ma, Lei Zhang
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Development of membrane-targeting TPP+-chloramphenicol conjugates to combat methicillin-resistant staphylococcus aureus (MRSA) infections Eur. J. Med. Chem. (IF 6.7) Pub Date : 2023-11-27 Tao Li, Xiaoli He, Wenlan Tao, Ruixue Zhang, Qiaolin He, Hongzhi Gong, Ye Liu, Dong Luo, Maojie Zhang, Cheng Zou, Shao-Lin Zhang, Yun He
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The formyl peptide receptors FPR1 and FPR2 as a target for inflammatory disorders: Recent advances in the development of small-molecule agonists Eur. J. Med. Chem. (IF 6.7) Pub Date : 2023-11-27 Xiangyan Yi, Eric Tran, Jephthah O. Odiba, Cheng Xue Qin, Rebecca H. Ritchie, Jonathan B. Baell
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Research progress of hexokinase 2 in inflammatory-related diseases and its inhibitors Eur. J. Med. Chem. (IF 6.7) Pub Date : 2023-11-23 Jinxia Chen, Guirong Li, Dejuan Sun, Hua Li, Lixia Chen
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Discovery of 4-aminophenylacetamide derivatives as intestine-specific farnesoid X receptor antagonists for the potential treatment of nonalcoholic steatohepatitis Eur. J. Med. Chem. (IF 6.7) Pub Date : 2023-11-27 Cong Chen, Bing Zhang, Jiaojiao Tu, Yanfen Peng, Yihuan Zhou, Xinping Yang, Qiming Yu, Xiangduan Tan
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Design, synthesis and biological evaluation of biaryl amide derivatives against SARS-CoV-2 with dual-target mechanism Eur. J. Med. Chem. (IF 6.7) Pub Date : 2023-11-25 Jiayu Li, Xiuli Zhong, Hongying Li, Zhihui Yu, Jianrui Li, Qionglu Duan, Yinghong Li, Fenbei Chen, Yanxiang Wang, Zhiyun Wu, Yonghua Liu, Zonggen Peng, Danqing Song
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Biotin-conjugated Ru(II) complexes with AIE characteristics as mitochondria-targeted photosensitizers for enhancing photodynamic therapy by disrupting cellular redox balance Eur. J. Med. Chem. (IF 6.7) Pub Date : 2023-11-23 Lai Wei, Xiangdong He, Deming Zhao, Martha Kandawa-Shultz, Guoqiang Shao, Yihong Wang
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Development of de-novo coronavirus 3-chymotrypsin-like protease (3CLpro) inhibitors since COVID-19 outbreak: A strategy to tackle challenges of persistent virus infection Eur. J. Med. Chem. (IF 6.7) Pub Date : 2023-11-25 Lei Tian, Taotao Qiang, Xiuding Yang, Yue Gao, Xiaopei Zhai, Kairui Kang, Cong Du, Qi Lu, Hong Gao, Dezhu Zhang, Xiaolin Xie, Chengyuan Liang
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Synthetic GPR40/FFAR1 agonists: An exhaustive survey on the most recent chemical classes and their structure-activity relationships Eur. J. Med. Chem. (IF 6.7) Pub Date : 2023-11-25 Abhik Paul, Sourin Nahar, Pankaj Nahata, Arnab Sarkar, Avik Maji, Ajeya Samanta, Sanmoy Karmakar, Tapan Kumar Maity
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An imidazo[1,2-a]pyridine-pyridine derivative potently inhibits FLT3-ITD and FLT3-ITD secondary mutants, including gilteritinib-resistant FLT3-ITD/F691L Eur. J. Med. Chem. (IF 6.7) Pub Date : 2023-11-25 Xiuqi Wang, Rosa Anna DeFilippis, Tsigereda Weldemichael, Naresh Gunaganti, Phuc Tran, Yuet-Kin Leung, Neil P. Shah, Hong-yu Li
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A glycyrrhetinic acid-iridium(III) conjugate as a theranostic NIR probe for hepatocellular carcinoma with mitochondrial-targeting ability Eur. J. Med. Chem. (IF 6.7) Pub Date : 2023-11-25 Ling Wang, Xueliang Wang, Feng Chen, Ying-Qi Song, Sang-Cuo Nao, Daniel Shiu-Hin Chan, Chun-Yuen Wong, Wanhe Wang, Chung-Hang Leung
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Small molecules targeting selected histone methyltransferases (HMTs) for cancer treatment: Current progress and novel strategies Eur. J. Med. Chem. (IF 6.7) Pub Date : 2023-11-25 Deping Li, Xiaopeng Peng, Zhihao Hu, Shuqing Li, Jianjun Chen, Wanyi Pan
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Novel Platinum(IV) complexes intervene oxaliplatin resistance in colon cancer via inducing ferroptosis and apoptosis Eur. J. Med. Chem. (IF 6.7) Pub Date : 2023-11-19 Zhikun Liu, Jinyuan Cai, Guiyang Jiang, Meng Wang, Chuang Wu, Kangning Su, Weiwei Hu, Yaxian Huang, Chunhao Yu, Xiaochao Huang, Guoxiu Cao, Hengshan Wang
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Novel ligustilide derivatives target quorum sensing system LasR/LasB and relieve inflammatory response against Pseudomonas aeruginosa infection Eur. J. Med. Chem. (IF 6.7) Pub Date : 2023-11-20 Jun Liu, Qiu-Xian Chen, Wen-Fu Wu, Dong Wang, Si-Yu Zhao, Jia-Hao Li, Yi-Qun Chang, Shao-Gao Zeng, Jia-Yi Hu, Yu-Jie Li, Jia-Xin Du, Shu-Meng Jiao, Hai-Chuan Xiao, Qiang Zhang, Jun Xu, Jian-Fu Zhao, Hai-Bo Zhou, Yong-Heng Wang, Jian Zou, Ping-Hua Sun
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Mitochondria-targeted pentacyclic triterpene NIR-AIE derivatives for enhanced chemotherapeutic and chemo-photodynamic combined therapy Eur. J. Med. Chem. (IF 6.7) Pub Date : 2023-11-24 Xiang Wang, Xuewei Zhang, Guoxing Zheng, Mingming Dong, Zhaopeng Huang, Liyin Lin, Kang Yan, Jinhong Zheng, Jinzhi Wang
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Synthesis and biological evaluation of indole derivatives containing thiazolidine-2,4-dione as α-glucosidase inhibitors with antidiabetic activity Eur. J. Med. Chem. (IF 6.7) Pub Date : 2023-11-24 Chunmei Hu, Bingwen Liang, Jinping Sun, Jiangyi Li, Zhuang Xiong, Shao-Hua Wang, Xu Xuetao
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Is it still worth renewing nucleoside anticancer drugs nowadays? Eur. J. Med. Chem. (IF 6.7) Pub Date : 2023-11-24 Zai-Qun Liu
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Brazilin-7-acetate, a novel potential drug of Parkinson's disease, hinders the formation of α-synuclein fibril, mitigates cytotoxicity, and decreases oxidative stress Eur. J. Med. Chem. (IF 6.7) Pub Date : 2023-11-23 Zhan Cui, Fang-Yan Guo, Li Li, Fuping Lu, Cheng-Hua Jin, Xiangming Wang, Fufeng Liu
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A systematic review on the current status of PSMA-targeted imaging and radioligand therapy Eur. J. Med. Chem. (IF 6.7) Pub Date : 2023-11-17 Giuseppe Capasso, Azzurra Stefanucci, Anna Tolomeo
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Discovery of C-3 isoxazole substituted thiochromone S,S-dioxide derivatives as potent and selective inhibitors for monoamine oxidase B (MAO-B) Eur. J. Med. Chem. (IF 6.7) Pub Date : 2023-11-20 Pengbing Mi, Yan Tan, Shiying Ye, Jia-Jia Lang, You Lv, Jinhuan Jiang, Limei Chen, Jianxiong luo, Yuqing Lin, Zhonghua Yuan, Xing Zheng, Ying-Wu Lin
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Serendipitous discovery of Class I HDAC inhibitors from rational design of molecular glue degraders targeting HDAC Eur. J. Med. Chem. (IF 6.7) Pub Date : 2023-11-19 Di Chen, Shuxian Lin, Ziwei Zeng, Jianxiong An, Wanli Yan, Zhicheng Gu, Lei Chen, Bin He
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Structure-based design of potent FABP4 inhibitors with high selectivity against FABP3 Eur. J. Med. Chem. (IF 6.7) Pub Date : 2023-11-22 Guofeng Chen, Hang Xie, Mengyuan You, Jiayuan Liu, Qiang Shao, Minjun Li, Haixia Su, Yechun Xu
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Reassessing the putative molecular Target(s) of potent antitubercular 2-(Alkylsulfonyl)acetamides Eur. J. Med. Chem. (IF 6.7) Pub Date : 2023-11-22 Dylan C. Farr, Thomas Haselhorst, Lendl Tan, Juanelle Furness, Emily Strong, I. Darren Grice, Nicholas P. West, Todd A. Houston
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Design, synthesis, and biological evaluation of 4-(2-fluorophenoxy)-7-methoxyquinazoline derivatives as dual EGFR/c-Met inhibitors for the treatment of NSCLC Eur. J. Med. Chem. (IF 6.7) Pub Date : 2023-11-15 Sheng Tang, Chuanchuan Sun, Xintao He, Wenhui Gan, Linxiao Wang, Dan Qiao, Xinyu Guan, Shan Xu, Pengwu Zheng, Wufu Zhu
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Discovery of an orally active nitrothiophene-based antitrypanosomal agent Eur. J. Med. Chem. (IF 6.7) Pub Date : 2023-11-15 Oluwatomi Ajayi, Damilohun S. Metibemu, Olamide Crown, Olawale S. Adeyinka, Marcel Kaiser, Nathalie Shoji, Mariana Silva, Ana Rodriguez, Ifedayo Victor Ogungbe
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Unexpected rearrangement of ivermectin in the synthesis of new derivatives with trypanocidal and antiplasmodial activities Eur. J. Med. Chem. (IF 6.7) Pub Date : 2023-11-16 Michał Sulik, Diana Fontinha, Dietmar Steverding, Szymon Sobczak, Michał Antoszczak, Miguel Prudêncio, Adam Huczyński
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Design and synthesis of pterostilbene derivatives bearing triazole moiety that might treat DSS-induced colitis in mice through modulation of NF-κB/MAPK signaling pathways Eur. J. Med. Chem. (IF 6.7) Pub Date : 2023-11-17 Liuzeng Chen, Ke Wang, Lingyun Wang, Wei Wang, Lifan Wang, Wei Wang, Jia Li, Xiaohan Liu, Mengya Wang, Banfeng Ruan
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Discovery of LWY713 as a potent and selective FLT3 PROTAC degrader with in vivo activity against acute myeloid leukemia Eur. J. Med. Chem. (IF 6.7) Pub Date : 2023-11-19 Wenyan Liu, Yu Bai, Licheng Zhou, Jian Jin, Meiying Zhang, Yongxing Wang, Runfeng Lin, Weixue Huang, Xiaomei Ren, Nan Ma, Fengtao Zhou, Zhen Wang, Ke Ding
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Discovery and optimization of thieno[3,2-d]pyrimidine derivatives as highly selective inhibitors of cyclin-dependent kinase 7 Eur. J. Med. Chem. (IF 6.7) Pub Date : 2023-11-17 Hongjin Zhang, Guohao Lin, Suyun Jia, Ying Zhang, Jianbo Wu, Yanxin Tao, Weixue Huang, Meiru Song, Ke Ding, Dawei Ma, Mengyang Fan
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Advances in targeting Phosphodiesterase 1: From mechanisms to potential therapeutics Eur. J. Med. Chem. (IF 6.7) Pub Date : 2023-11-17 Ziyu Zhu, Wentao Tang, Xuemei Qiu, Xin Xin, Jifa Zhang
更新日期：2023-12-06
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