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Design, synthesis and evaluation of 2′-acetylene-7-deaza-adenosine phosphoamidate derivatives as anti-EV71 and anti-EV-D68 agents Eur. J. Med. Chem. (IF 6.514) Pub Date : 2021-09-17 Linjie Yan, Ruiyuan Cao, Hongjie Zhang, Yuexiang Li, Wei Li, Xiaoyuan Li, Shiyong Fan, Song Li, Wu Zhong
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Ligand-based rational design, synthesis and evaluation of novel potential chemical chaperones for opsin Eur. J. Med. Chem. (IF 6.514) Pub Date : 2021-09-17 Gaia Pasqualetto, Elisa Pileggi, Martin Schepelmann, Carmine Varricchio, Malgorzata Rozanowska, Andrea Brancale, Marcella Bassetto
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Vincristine-doxorubicin co-loaded artificial low-density lipoproteins towards solid tumours Eur. J. Med. Chem. (IF 6.514) Pub Date : 2021-09-04 Mingyuan Li, Siyu Ma, Xiangyang Xie, Nan Liu, Zhiping Li, Zhenbo Yang, Guangyu Gao, Shiqin Li, Yuan Li, Shuangshuang Li, Xingguo Mei, Hui Zhang
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A camptothecin-based, albumin-binding prodrug enhances efficacy and safety in vivo Eur. J. Med. Chem. (IF 6.514) Pub Date : 2021-09-16 Zhiyang Cheng, Ying Huang, Qianqian Shen, Yangrong Zhao, Lei Wang, Jiahui Yu, Wei Lu
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Design, synthesis, and mechanism study of dimerized phenylalanine derivatives as novel HIV-1 capsid inhibitors Eur. J. Med. Chem. (IF 6.514) Pub Date : 2021-09-16 Xujie Zhang, Lin Sun, Megan E. Meuser, Waleed A. Zalloum, Shujing Xu, Tianguang Huang, Srinivasulu Cherukupalli, Xiangyi Jiang, Xiao Ding, Yucen Tao, Dongwei Kang, Erik De Clercq, Christophe Pannecouque, Alexej Dick, Simon Cocklin, Xinyong Liu, Peng Zhan
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Piperazine squaric acid diamides, a novel class of allosteric P2X7 receptor antagonists Eur. J. Med. Chem. (IF 6.514) Pub Date : 2021-09-16 Marius Patberg, Andreas Isaak, Friederike Füsser, Natalia V. Ortiz Zacarías, Laura Vinnenberg, Janine Schulte, Lucia Michetti, Lucie Grey, Cas van der Horst, Petra Hundehege, Oliver Koch, Laura H. Heitman, Thomas Budde, Anna Junker
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Drugs for the treatment of glaucoma: Targets, structure-activity relationships and clinical research Eur. J. Med. Chem. (IF 6.514) Pub Date : 2021-09-11 Xianbo Wu, Xinwei Yang, Qi Liang, Xiali Xue, Jianli Huang, Jie Wang, Yihua Xu, Rongsheng Tong, Maoyu Liu, Qiaodan Zhou, Jianyou Shi
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Discovery and development of CPL207280 as new GPR40/FFA1 agonist Eur. J. Med. Chem. (IF 6.514) Pub Date : 2021-09-01 Mateusz Mach, Katarzyna Bazydło-Guzenda, Paweł Buda, Mikołaj Matłoka, Radosław Dzida, Filip Stelmach, Kinga Gałązka, Małgorzata Wąsińska-Kałwa, Damian Smuga, Dagmara Hołowińska, Urszula Dawid, Lidia Gurba-Bryśkiewicz, Krzysztof Wiśniewski, Krzysztof Dubiel, Jerzy Pieczykolan, Maciej Wieczorek
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Design and application of hybrid cyclic-linear peptide-doxorubicin conjugates as a strategy to overcome doxorubicin resistance and toxicity Eur. J. Med. Chem. (IF 6.514) Pub Date : 2021-09-10 Saghar Mozaffari, David Salehi, Parvin Mahdipoor, Richard Beuttler, Rakesh Tiwari, Hamidreza Montazeri Aliabadi, Keykavous Parang
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A novel methylenemalononitrile-BODIPY-based fluorescent probe for highly selective detection of hydrogen peroxide in living cells Eur. J. Med. Chem. (IF 6.514) Pub Date : 2021-09-06 Yong-Feng Wei, Xuan Wang, Wen-Jing Shi, Ru Chen, Liyao Zheng, Zi-Zhou Wang, Kun Chen, Liqian Gao
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Design, synthesis and anti-tumor evaluation of 1,2,4-triazol-3-one derivatives and pyridazinone derivatives as novel CXCR2 antagonists Eur. J. Med. Chem. (IF 6.514) Pub Date : 2021-09-09 Xun Zhang, Jingyi Luo, Qinyuan Li, Qilei Xin, Lizhen Ye, Qingyun Zhu, Zhichao Shi, Feng Zhan, Bizhu Chu, Zijian Liu, Yuyang Jiang
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Discovery of highly potent human glutaminyl cyclase (QC) inhibitors as anti-Alzheimer's agents by the combination of pharmacophore-based and structure-based design Eur. J. Med. Chem. (IF 6.514) Pub Date : 2021-09-08 Nguyen Van Manh, Van-Hai Hoang, Van T.H. Ngo, Jihyae Ann, Tae-ho Jang, Jung-Hye Ha, Jae Young Song, Hee-Jin Ha, Hee Kim, Young-Ho Kim, Jiyoun Lee, Jeewoo Lee
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Anti-schistosomal activities of quinoxaline-containing compounds: From hit identification to lead optimisation Eur. J. Med. Chem. (IF 6.514) Pub Date : 2021-09-10 Gilda Padalino, Nelly El-Sakkary, Lawrence J. Liu, Chenxi Liu, Danielle S.G. Harte, Rachel E. Barnes, Edward Sayers, Josephine Forde-Thomas, Helen Whiteland, Marcella Bassetto, Salvatore Ferla, George Johnson, Arwyn T. Jones, Conor R. Caffrey, Iain Chalmers, Andrea Brancale, Karl F. Hoffmann
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N-2-(phenylamino) benzamide derivatives as novel anti-glioblastoma agents: Synthesis and biological evaluation Eur. J. Med. Chem. (IF 6.514) Pub Date : 2021-09-10 Junfang Li, Xiaoling Hu, Tian Luo, Yingmei Lu, Yiyue Feng, Honghua Zhang, Dan Liu, Xiaohong Fan, Yuqing Wang, Liming Jiang, Yuying Wang, Xiangyong Hao, Tao Shi, Zhen Wang
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Pharmacological inhibition of KDM5A for cancer treatment Eur. J. Med. Chem. (IF 6.514) Pub Date : 2021-09-15 Guan-Jun Yang, Jia Wu, Liang Miao, Ming-Hui Zhu, Qian-Jin Zhou, Xin-Jiang Lu, Jian-Fei Lu, Chung-Hang Leung, Dik-Lung Ma, Jiong Chen
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Retinol binding protein 4 antagonists and protein synthesis inhibitors: Potential for therapeutic development Eur. J. Med. Chem. (IF 6.514) Pub Date : 2021-09-15 Noheul Kim, Ronny Priefer
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Plant isoquinoline alkaloids: Advances in the chemistry and biology of berberine Eur. J. Med. Chem. (IF 6.514) Pub Date : 2021-09-09 Sneha Singh, Nandini Pathak, Eram Fatima, Arvind Singh Negi
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Design, synthesis, and biological evaluation of novel pyrrolidinone small-molecule Formyl peptide receptor 2 agonists Eur. J. Med. Chem. (IF 6.514) Pub Date : 2021-09-02 Monika Maciuszek, Almudena Ortega-Gomez, Sanne L. Maas, Jose Garrido-Mesa, Bartolo Ferraro, Mauro Perretti, Andy Merritt, Gerry A.F. Nicolaes, Oliver Soehnlein, Timothy M. Chapman
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Targeting transthyretin in Alzheimer's disease: Drug discovery of small-molecule chaperones as disease-modifying drug candidates for Alzheimer's disease Eur. J. Med. Chem. (IF 6.514) Pub Date : 2021-09-14 Ellen Y. Cotrina, Luis Miguel Santos, Josep Rivas, Daniel Blasi, José Pedro Leite, Márcia A. Liz, Maria Antònia Busquets, Antoni Planas, Rafel Prohens, Ana Gimeno, Jesús Jiménez-Barbero, Luis Gales, Jordi Llop, Jordi Quintana, Isabel Cardoso, Gemma Arsequell
Transthyretin (TTR) has a well-established role in neuroprotection in Alzheimer's Disease (AD). We have setup a drug discovery program of small-molecule compounds that act as chaperones enhancing TTR/Amyloid-beta peptide (Aβ) interactions. A combination of computational drug repurposing approaches and in vitro biological assays have resulted in a set of molecules which were then screened with our in-house
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Indomethacin-based PROTACs as pan-coronavirus antiviral agents Eur. J. Med. Chem. (IF 6.514) Pub Date : 2021-09-04 Jenny Desantis, Beatrice Mercorelli, Marta Celegato, Federico Croci, Alessandro Bazzacco, Massimo Baroni, Lydia Siragusa, Gabriele Cruciani, Arianna Loregian, Laura Goracci
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A tacrine-tetrahydroquinoline heterodimer potently inhibits acetylcholinesterase activity and enhances neurotransmission in mice Eur. J. Med. Chem. (IF 6.514) Pub Date : 2021-09-13 Fanny C.F. Ip, Guangmiao Fu, Fengzhi Yang, Fangyuan Kang, Peiran Sun, Choi Ying Ling, Kit Cheung, Fangzhou Xie, Yueqing Hu, Lei Fu, Nancy Y. Ip
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Design, synthesis and biological evaluation of aminopyrimidine derivatives bearing a 4,5,6,7-tetrahydrothieno [3,2-c]pyridine as potent EGFR inhibitors Eur. J. Med. Chem. (IF 6.514) Pub Date : 2021-09-11 Yingxue Li, Yaoyao Chang, Jianfang Fu, Rongcai Ding, Lingyun Zhang, Tian Liang, Yajing Liu, Yue Liu, Jinxing Hu
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Progress in the development of domain selective inhibitors of the bromo and extra terminal domain family (BET) proteins Eur. J. Med. Chem. (IF 6.514) Pub Date : 2021-09-13 Yuantao Fu, Yanzhi Zhang, Haiying Sun
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The heat shock response and small molecule regulators Eur. J. Med. Chem. (IF 6.514) Pub Date : 2021-09-13 Margaret K. Kurop, Cormac M. Huyen, John H. Kelly, Brian S.J. Blagg
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Sulfonamide derivatives as potential anti-cancer agents and their SARs elucidation Eur. J. Med. Chem. (IF 6.514) Pub Date : 2021-09-08 Yichao Wan, Guoqing Fang, Hongjuan Chen, Xu Deng, Zilong Tang
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Design, synthesis and bioevaluation of 6-aryl-1-(3,4,5-trimethoxyphenyl)-1H-benzo[d]imidazoles as tubulin polymerization inhibitors Eur. J. Med. Chem. (IF 6.514) Pub Date : 2021-09-11 Runlai Liu, Mingxin Huang, Shuai Zhang, Long Li, Mi Li, Jun Sun, Lan Wu, Qi Guan, Weige Zhang
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Novel strategies to improve tumour therapy by targeting the proteins MCT1, MCT4 and LAT1 Eur. J. Med. Chem. (IF 6.514) Pub Date : 2021-08-26 Yang Wang, Liuxin Qin, Weiwei Chen, Qing Chen, Jin Sun, Gang Wang
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Targeting mutated GTPase KRAS in tumor therapies Eur. J. Med. Chem. (IF 6.514) Pub Date : 2021-09-04 Guangjin Fan, Linlin Lou, Zhendong Song, Xiaolei Zhang, Xiao-Feng Xiong
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Divergent synthesis and biological evaluation of 2-(trifluoromethyl)pyridines as virulence-attenuating inverse agonists targeting PqsR Eur. J. Med. Chem. (IF 6.514) Pub Date : 2021-08-28 Christian Schütz, Amir Hodzic, Mostafa Hamed, Ahmed S. Abdelsamie, Andreas M. Kany, Maximilian Bauer, Teresa Röhrig, Stefan Schmelz, Andrea Scrima, Wulf Blankenfeldt, Martin Empting
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6-Fluorophenylbenzohydrazides inhibit Mycobacterium tuberculosis growth through alteration of tryptophan biosynthesis Eur. J. Med. Chem. (IF 6.514) Pub Date : 2021-09-09 Sara Consalvi, Giulia Venditti, Junhao Zhu, Helena I. Boshoff, Kriti Arora, Alessandro De Logu, Thomas R. Ioerger, Eric J. Rubin, Mariangela Biava, Giovanna Poce
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Synthesis and biological evaluation of indole-based peptidomimetics as antibacterial agents against Gram-positive bacteria Eur. J. Med. Chem. (IF 6.514) Pub Date : 2021-08-31 Yongzhi Chen, Hongxia Li, Jiayong Liu, Rongcui Zhong, Haizhou Li, Shanfang Fang, Shouping Liu, Shuimu Lin
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Peptidylarginine deiminases 4 as a promising target in drug discovery Eur. J. Med. Chem. (IF 6.514) Pub Date : 2021-09-09 Chao Yang, Zhen-Zhen Dong, Jing Zhang, Dehong Teng, Xinzhi Luo, Dan Li, Yingtang Zhou
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Discovery of a cryptic site at the interface 2 of TEAD – Towards a new family of YAP/TAZ-TEAD inhibitors Eur. J. Med. Chem. (IF 6.514) Pub Date : 2021-09-06 Manon Sturbaut, Fabrice Bailly, Mathilde Coevoet, Pasquale Sileo, Martine Pugniere, Maxime Liberelle, Romain Magnez, Xavier Thuru, Marie-Christine Chartier-Harlin, Patricia Melnyk, Muriel Gelin, Frédéric Allemand, Jean-François Guichou, Philippe Cotelle
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Discovery of novel BTK PROTACs for B-Cell lymphomas Eur. J. Med. Chem. (IF 6.514) Pub Date : 2021-09-02 Yunpeng Zhao, Yongzhi Shu, Jun Lin, Zhendong Chen, Qiong Xie, Yanning Bao, Lixue Lu, Nannan Sun, Yonghui Wang
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Design, synthesis and biological evaluation of novel hybrids targeting mTOR and HDACs for potential treatment of hepatocellular carcinoma Eur. J. Med. Chem. (IF 6.514) Pub Date : 2021-09-03 Shiyang Zhai, Huimin Zhang, Rui Chen, Jiangxia Wu, Daiqiao Ai, Shunming Tao, Yike Cai, Ji-Quan Zhang, Ling Wang
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Chalcogenides-incorporating carbonic anhydrase inhibitors concomitantly reverted oxaliplatin-induced neuropathy and enhanced antiproliferative action Eur. J. Med. Chem. (IF 6.514) Pub Date : 2021-08-23 Damiano Tanini, Simone Carradori, Antonella Capperucci, Lucrezia Lupori, Susi Zara, Marta Ferraroni, Carla Ghelardini, Lorenzo Di Cesare Mannelli, Laura Micheli, Elena Lucarini, Fabrizio Carta, Andrea Angeli, Claudiu T. Supuran
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Targeted methylation facilitates DNA double strand breaks and enhances cancer suppression: A DNA intercalating/methylating dual-action chimera Amonafidazene Eur. J. Med. Chem. (IF 6.514) Pub Date : 2021-08-31 Dipak Walunj, Ebaston Thankarajan, Chandrashekhar Prasad, Helena Tuchinsky, Simone Baldan, Michael Y. Sherman, Leonid Patsenker, Gary Gellerman
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Cysteine derivatives as acetyl lysine mimics to inhibit zinc-dependent histone deacetylases for treating cancer Eur. J. Med. Chem. (IF 6.514) Pub Date : 2021-08-27 Jie Wang, Zhuoxian Cao, Fang Wang, Pan Wang, Jianxiong An, Xiaozhong Fu, Ting Liu, Yan Li, Yongjun Li, Yonglong Zhao, Hening Lin, Bin He
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Combining histone deacetylase inhibitors (HDACis) with other therapies for cancer therapy Eur. J. Med. Chem. (IF 6.514) Pub Date : 2021-09-04 Mengjiao Zhou, Minjian Yuan, Meng Zhang, Chenyi Lei, Omer Aras, Xiaohong Zhang, Feifei An
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Development of [18F]MIPS15692, a radiotracer with in vitro proof-of-concept for the imaging of MER tyrosine kinase (MERTK) in neuroinflammatory disease Eur. J. Med. Chem. (IF 6.514) Pub Date : 2021-09-04 Siu Wai Wong, Lucy Vivash, Ramesh Mudududdla, Nghi Nguyen, Stefan J. Hermans, David M. Shackleford, Judith Field, Lian Xue, Andrea Aprico, Nancy C. Hancock, Mohammad Haskali, Michael A. Stashko, Stephen V. Frye, Xiaodong Wang, Michele D. Binder, Uwe Ackermann, Michael W. Parker, Trevor J. Kilpatrick, Jonathan B. Baell
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Cathepsin C inhibitors as anti-inflammatory drug discovery: Challenges and opportunities Eur. J. Med. Chem. (IF 6.514) Pub Date : 2021-09-03 Xiao Bao Shen, Xing Chen, Zhao Yan Zhang, Fu Fang Wu, Xin Hua Liu
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Synthesis and biological evaluation of selective histone deacetylase 6 inhibitors as multifunctional agents against Alzheimer's disease Eur. J. Med. Chem. (IF 6.514) Pub Date : 2021-09-03 Xiu-Xiu Wang, Fei Xie, Cong-Cong Jia, Ning Yan, Yan-Li Zeng, Jing-De Wu, Zhao-Peng Liu
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Design, synthesis and biological evaluation of quinazoline derivatives as potent and selective FGFR4 inhibitors Eur. J. Med. Chem. (IF 6.514) Pub Date : 2021-08-19 Chenghao Pan, Wenwen Nie, Jiao Wang, Jiamin Du, Zhichao Pan, Jian Gao, Yang Lu, Jinxin Che, Hong Zhu, Haibin Dai, Binhui Chen, Qiaojun He, Xiaowu Dong
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Natural inspired piperine-based sulfonamides and carboxylic acids as carbonic anhydrase inhibitors: Design, synthesis and biological evaluation Eur. J. Med. Chem. (IF 6.514) Pub Date : 2021-08-25 Diaaeldin M. Elimam, Abdullah A. Elgazar, Alessandro Bonardi, Mohamed Abdelfadil, Alessio Nocentini, Ramadan A. El-Domany, Hatem A. Abdel-Aziz, Farid A. Badria, Claudiu T. Supuran, Wagdy M. Eldehna
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Further hit optimization of 6-(trifluoromethyl)pyrimidin-2-amine based TLR8 modulators: Synthesis, biological evaluation and structure–activity relationships Eur. J. Med. Chem. (IF 6.514) Pub Date : 2021-08-28 Ana Dolšak, Dora Šribar, Alexander Scheffler, Maria Grabowski, Urban Švajger, Stanislav Gobec, Janine Holze, Günther Weindl, Gerhard Wolber, Matej Sova
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C1′-Branched acyclic nucleoside phosphonates mimicking adenosine monophosphate: Potent inhibitors of Trypanosoma brucei adenine phosphoribosyltransferase Eur. J. Med. Chem. (IF 6.514) Pub Date : 2021-08-25 Filip Kalčic, Jan Frydrych, Eva Doleželová, Martina Slapničková, Petr Pachl, Lenka Poštová Slavětínská, Martin Dračínský, Dana Hocková, Alena Zíková, Zlatko Janeba
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Synthesis and evaluation of stereoisomers of methylated catechin and epigallocatechin derivatives on modulating P-glycoprotein-mediated multidrug resistance in cancers Eur. J. Med. Chem. (IF 6.514) Pub Date : 2021-09-01 Iris L.K. Wong, Xing-kai Wang, Zhen Liu, Wenqin Sun, Fu-xing Li, Bao-chao Wang, Peng Li, Sheng-biao Wan, Larry M.C. Chow
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Discovery of imidazo[1,2-a]pyridine-thiophene derivatives as FLT3 and FLT3 mutants inhibitors for acute myeloid leukemia through structure-based optimization of an NEK2 inhibitor Eur. J. Med. Chem. (IF 6.514) Pub Date : 2021-08-17 Lingtian Zhang, Naga Rajiv Lakkaniga, Jaideep B. Bharate, Nicholas Mcconnell, Xiuqi Wang, Anupreet Kharbanda, Yuet-Kin Leung, Brendan Frett, Neil P. Shah, Hong-yu Li
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A review of synthetic bioactive tetrahydro-β-carbolines: A medicinal chemistry perspective Eur. J. Med. Chem. (IF 6.514) Pub Date : 2021-08-30 Jiayun Wang, Feihu Gong, Ting Liang, Zhao Xie, Yingxiang Yang, Chenyu Cao, Jinming Gao, Tao Lu, Xin Chen
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Synthetically-tailored and nature-derived dual COX-2/5-LOX inhibitors: Structural aspects and SAR Eur. J. Med. Chem. (IF 6.514) Pub Date : 2021-08-27 Minakshi A. Meshram, Utkarsha O. Bhise, Priyanka N. Makhal, Venkata Rao Kaki
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PSMA-targeted low-molecular double conjugates for diagnostics and therapy Eur. J. Med. Chem. (IF 6.514) Pub Date : 2021-08-08 Stanislav A. Petrov, Nikolay Y. Zyk, Aleksei E. Machulkin, Elena K. Beloglazkina, Alexander G. Majouga
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Discovery of 1-(phenylsulfonyl)-1H-indole-based multifunctional ligands targeting cholinesterases and 5-HT6 receptor with anti-aggregation properties against amyloid-beta and tau Eur. J. Med. Chem. (IF 6.514) Pub Date : 2021-08-19 Tomasz Wichur, Anna Pasieka, Justyna Godyń, Dawid Panek, Izabella Góral, Gniewomir Latacz, Ewelina Honkisz-Orzechowska, Adam Bucki, Agata Siwek, Monika Głuch-Lutwin, Damijan Knez, Xavier Brazzolotto, Stanislav Gobec, Marcin Kołaczkowski, Raimon Sabate, Barbara Malawska, Anna Więckowska
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Discovery of new human Sirtuin 5 inhibitors by mimicking glutaryl-lysine substrates Eur. J. Med. Chem. (IF 6.514) Pub Date : 2021-08-26 Fan Yang, Huilin Su, Ji Deng, Luohe Mou, Huali Wang, Rong Li, Qing-Qing Dai, Yu-Hang Yan, Shan Qian, Zhouyu Wang, Guo-Bo Li, Lingling Yang
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Development of specific and selective bactericide by introducing exogenous metabolite of pathogenic bacteria Eur. J. Med. Chem. (IF 6.514) Pub Date : 2021-08-26 Min-Hui Cao, Bao-He Tang, Yao Ruan, Xiao-Long Liang, Xin-Yi Chu, Zhan-Min Liang, Qing-Ye Zhang, Hong-Yu Zhang
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A sulfonyl fluoride derivative inhibits EGFRL858R/T790M/C797S by covalent modification of the catalytic lysine Eur. J. Med. Chem. (IF 6.514) Pub Date : 2021-08-27 Francesca Ferlenghi, Laura Scalvini, Federica Vacondio, Riccardo Castelli, Nicole Bozza, Giuseppe Marseglia, Silvia Rivara, Alessio Lodola, Silvia La Monica, Roberta Minari, Pier Giorgio Petronini, Roberta Alfieri, Marcello Tiseo, Marco Mor
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Development and crystallography-aided SAR studies of multifunctional BuChE inhibitors and 5-HT6R antagonists with β-amyloid anti-aggregation properties Eur. J. Med. Chem. (IF 6.514) Pub Date : 2021-08-27 Tomasz Wichur, Justyna Godyń, Izabella Góral, Gniewomir Latacz, Adam Bucki, Agata Siwek, Monika Głuch-Lutwin, Barbara Mordyl, Joanna Śniecikowska, Maria Walczak, Damijan Knez, Marko Jukic, Kinga Sałat, Stanislav Gobec, Marcin Kołaczkowski, Barbara Malawska, Xavier Brazzolotto, Anna Więckowska
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Discovery of the first-in-class dual PPARδ/γ partial agonist for the treatment of metabolic syndrome Eur. J. Med. Chem. (IF 6.514) Pub Date : 2021-08-25 Zheng Li, Qiang Ren, Zongtao Zhou, Zongyu Cai, Bin Wang, Jing Han, Luyong Zhang
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Discovery of 1,2,4-triazine dithiocarbamate derivatives as NEDDylation agonists to inhibit gastric cancers Eur. J. Med. Chem. (IF 6.514) Pub Date : 2021-08-26 Jian Song, Yuan Liu, Xin-Ying Yuan, Wen-Bo Liu, Yin-Ru Li, Guang-Xi Yu, Xin-Yi Tian, Yan-Bing Zhang, Xiang-Jing Fu, Sai-Yang Zhang
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Structure-activity relationships of agonists for the orphan G protein-coupled receptor GPR27 Eur. J. Med. Chem. (IF 6.514) Pub Date : 2021-08-14 Thanigaimalai Pillaiyar, Francesca Rosato, Monika Wozniak, Jeremy Blavier, Maëlle Charles, Céline Laschet, Thales Kronenberger, Christa E. Müller, Julien Hanson
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Design, synthesis and evaluation of heteroaryldihydropyrimidine analogues bearing spiro ring as hepatitis B virus capsid protein inhibitors Eur. J. Med. Chem. (IF 6.514) Pub Date : 2021-08-19 Yue Ma, Shujie Zhao, Yujie Ren, Srinivasulu Cherukupalli, Qilan Li, Molly E. Woodson, Daniel P. Bradley, John E. Tavis, Xinyong Liu, Peng Zhan
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