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Development of Coumarin and Procaine Linked Hybrid Molecules as A Novel Class of SHP1 Fluorescent Activators Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-02-17 Xu-Yang Mu, Li-Xin Gao, Zhen-Xuan Zhang, Zi-Tong Cao, Qing Cao, Chun Zhang, Jia Li, Da-Jun Xiang, Yu-Bo Zhou, Wen-Long Wang
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Discovery of Potent Quinone Oxidoreductase 2 inhibitors to Overcome TRAIL Resistance of non-small cell lung cancer Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-02-16 Si-jie Qi, Ke-xin Liu, Hao-yu Liu, Gao-qiang Zhang, Hong-bo Zheng, Jia-yu Sun, Bin Sun, Hong-xiang Lou
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Discovery of highly potent dual GSPT1/BRD4 degraders with anti-AML activity Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-02-12 Yue Xu, Hang Yang, Yunxuan Li, Yuying Qi, Fangling Zhao, Yun Hong, Binbin Cheng, Zebei Lu, Jiaming Zhang, Chunyi Guo, Jie Fu, Qinrong Lin, Chunhong Chen, Ningning Shi, Jianping Cai, Ke Li, Shuanghu Wang, Ruijuan Gao, Dapeng Dai
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Design, synthesis, and biological evaluation of β-carboline derivatives as ABCB1 inhibitors for reversing multidrug resistance Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-02-13 Yuanyuan Wang, Nanjin Ding, Yunpeng Zhao, Fengqing Wang, Wen Liu, Zhe Chen, Weiguang Sun, Lianghu Gu, Yonghui Zhang
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A Progress Report in Advancements of Heterocyclic Compounds as Novel Antimalarial Agents over the Last 5 Years Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-02-16 Sumit Tahlan, Sucheta Singh, Meenakshi Kaira, Hrithik Dey, Kailash C. Pandey
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Substitutions at the C-8 position of quinazolin-4-ones improve the potency of nicotinamide site binding tankyrase inhibitors Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-02-15 Chiara Bosetti, Dionysis Kampasis, Shoshy A. Brinch, Albert Galera-Prat, Maria Karelou, Saurabh S. Dhakar, Juho Alaviuhkola, Jo Waaler, Lari Lehtiö, Ioannis K. Kostakis
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The assembled decoders to prepare for “bioactive X” against progressive deterioration of liver disease: from NAFLD to HCC Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-02-15 Ki-Kwang Oh, Sang-Jun Yoon, Jung-A Eom, Kyeong Jin Lee, Goo-Hyun Kwon, Dong Joon Kim, Ki-Tae Suk
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Discovery of 3-hydroxypyridin-4(1H)-ones ester of ciprofloxacin as prodrug to combat biofilm-associated Pseudomonas aeruginosa Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-02-15 Yuan-Yuan Wang, Bao-Zhang Luo, Chang-Ming Li, Jian-Long Liang, Zheng Liu, Wei-Min Chen, Jia-Liang Guo
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Design, synthesis, and biological evaluation of novel quinoline carboxylic acid based styryl/alkyne hybrid molecule as a potent anti-adipogenic and antidyslipidemic agent via activation of Wnt/β-catenin pathway Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-02-14 Richa Singh, Vinita Kushwaha, Sumit K. Rastogi, Prashant Rai, Santosh Kumar, Nilesh Khandelwal, Sanchita Gupta, Amol Chhatrapati Bisen, Salil Varshney, Astha Singh, Vishal M. Balaramnavar, Rabi Sankar Bhatta, Ravindra Kumar, Anil N. Gaikwad, Arun K. Sinha
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Natural pyrrolo[1,2-a]quinazolinone derivatives: Design, synthesis, characterization, and bio-evaluation as novel antiviral agents Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-02-14 Yanhong Wei, Fuqiang Zheng, Lirong Guo, Wenxuan Chen, Hexiang Wang, Longzhu Bao, Zhaoyuan Wu, Ying Li, W. Alateng, Jianglong Su, Mengmeng Kong, Shaoyong Ke
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Design and synthesis of novel thioether analogs as promising antiviral agents: in vitro activity against enteroviruses of interest. Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-02-14 Hugo Roux, Franck Touret, Antonio Coluccia, Pietro Scio, Hawa Sophia Bouzidi, Carole di Giorgio, Florence Gattacceca, Omar Khoumeri, Romano Silvestri, Patrice Vanelle, Manon Roche
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Discovery of β-amino acid substituted naphthalene sulfonamide derivatives as potent Kelch-like ECH-associated protein 1−nuclear factor erythroid 2-related factor 2 (Keap1−Nrf2) protein−protein interaction inhibitors for ulcerative colitis management Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-02-13 Ziquan Zhao, Hongjin Lu, Junjie Wang, Tingting Wu, Shicheng Xu, Yuxin Ge, Qidong You, Zhengyu Jiang, Mengchen Lu
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Discovery of novel Sitolactone derivative leading to PANoptosis and differentiation of acute myeloid leukemia cells Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-02-12 Jiefu Wang, Ning Wang, Mengmeng Wang, Ning Liu, Chenyang Wang, Ning Li, Linrong Mu, Yurui Jiang, Jia Chen, Jinxiao Li, Guang Yang, Junfeng Wang, Shuangwei Liu, Kun Zhang
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Design, synthesis and biological evaluation of pyrrolopyrimidine urea derivatives as novel KRASG12C inhibitors for the treatment of cancer Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-02-12 Yanguo Shang, Miaomiao Pang, Shengnan Fu, Wenjuan Fei, Boxuan Chen, yaoyao zhang, Jinxin Wang, Tao Shen
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Design, Synthesis, and Antitumor Activity of NSDs Inhibitors Targeting Lung Squamous Cell Carcinoma Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-02-12 Siyu Xiu, Zhenyu Jia, Zhiqi Wang, Huiyu Liu, Cheng Shi, Xiaojiao Sun, Xiangyu Zhang, Xiaowei Chi, Zhenming Liu, Liangren Zhang
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Identification of constrained peptidomimetics carrying a Michael acceptor warhead as antitrypanosomal agents Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-02-12 Santo Previti, Elsa Calcaterra, Carla Di Chio, Benito Natale, Muhammad Waqas, Marta Bogacz, Tanja Schirmeister, Florine Cavelier, Maria Luisa Calabrò, Sandro Cosconati, Roberta Ettari, Maria Zappalà
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Emerging drugs for Epstein-Barr virus associated-diseases Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-02-11 Nassima Oumata, Qian Zhong, Yongmin Zhang, Hervé Galons, Graciela Andrei, Musheng Zeng
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Synthesis and evaluation of piceatannol derivatives as novel arginase inhibitors with radical scavenging activity and their potential for collagen reduction in dermal fibroblasts Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-02-09 Luca Marchisio, Quentin Gaudillat, Jason Muller, Andy Zedet, Marion Tissot, Dominique Harakat, François Sénéjoux, Gwenaël Rolin, Bruno Cardey, Corine Girard, Marc Pudlo
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Corrigendum to “A chemical modification of a peroxisome proliferator-activated receptor pan agonist produced a shift to a new dual alpha/gamma partial agonist endowed with mitochondrial pyruvate carrier inhibition and antidiabetic properties” [Eur. J. Med. Chem. 275 (2024) 116567] Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-02-12 Antonio Laghezza, Carmen Cerchia, Massimo Genovese, Roberta Montanari, Davide Capelli, Judith Wackerlig, Stefan Simic, Emanuele Falbo, Lucia Pecora, Rosalba Leuci, Leonardo Brunetti, Luca Piemontese, Paolo Tortorella, Abanish Biswas, Ravi Pratap Singh, Suhas Tambe, C.A. Sudeep, Ashok Kumar Pattnaik, Venkatesan Jayaprakash, Paolo Paoli, Fulvio Loiodice
The authors regret.
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Synthesis and Mechanistic Insights of Coumarinyl-Indolinone Hybrids as Potent Inhibitors of Leishmania major Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-02-12 Rasha Z. Batran, Manal S. Ebaid, Sherry N. Nasralla, Ninh The Son, Nguyen Xuan Ha, Hoda Atef Abdelsattar Ibrahim, Mahmoud Abdelrahman Alkabbani, Yusuke Kasai, Hiroshi Imagawa, Mohammad M. Al-Sanea, Tamer M. Ibrahim, Abdelsamed I. Elshamy, Adnan A. Bekhit, Wagdy M. Eldehna, Ahmed Sabt
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Highlights on U.S. FDA-approved halogen-containing drugs in 2024 Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-02-09 Saghir Ali, Xiaochen Tian, Salvatore A. Meccia, Jia Zhou
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Discovery of novel thiazole-pleuromutilin derivatives with potent antibacterial activity Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-02-08 Xian-Long Qi, He-Chao Zhang, Xiao Xu, Xi-Wang Liu, Ya-Jun Yang, Zhun Li, Jian-Yong Li
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Discovery of naphthoquinone-furo-piperidone derivatives as dual targeting agents of STAT3 and NQO1 for the treatment of breast cancer Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-02-07 Shengying Lou, Chenjun Shen, Hao Ni, Chengcheng Fan, Zhihui Zhu, Xueping Hu, Huajun Zhao, Sunliang Cui
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Vitexin alleviates lipid metabolism disorders and hepatic injury in obese mice through the PI3K/AKT/mTOR/SREBP-1c pathway Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-02-07 Bo Liu, Ziqing Yao, Lin Song, Chen Sun, Changhong Shen, Fang Cheng, Zefang Cheng, Ruoqi Zhang, Rong Liu
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Diverse pharmacological activities of β-carbolines: Substitution patterns, SARs and mechanisms of action Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-02-06 Muneeb Ur Rehman, Yujie Zuo, Ni Tu, Ju Guo, Ziwei Liu, Shuang Cao, Sihui Long
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Structural optimization and characterization of highly potent and selective STAT3 inhibitors for the treatment of triple negative breast cancer Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-02-06 Wangrui Jin, Yuzhu Zhang, Baozhen Wang, Zhaoyong Kang, Huachao Li, Jingfeng Song, Yihua Chen, Hai Xiong, Jing Chen
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Discovery of novel imidazo[1,2-b]pyridazine derivatives as potent covalent inhibitors of CDK12/13 Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-02-10 Meng Xia, Ziteng Li, Hanrui Jiang, Yuanqing Li, Linghao Hu, Yongchang He, Siqi Huang, Lei Tang, Cheng Luo, Shuangxi Gu, Hong Ding, Mingliang Wang
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Synthesis and evolution of 16-membered macrolide carrimycin derivatives as a novel class of anti-HCoV-OC43 agents targeting viral FSE RNA Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-02-07 Xiuli Zhong, Zhihui Yu, Runze Meng, Yue Gong, Jianrui Li, Weiqing He, Hongying Li, Jiayu Li, Zhiyun Wu, Qionglu Duan, Yinghong Li, Yonghua Liu, Zonggen Peng, Danqing Song
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Application of deuterium in research and development of drugs Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-02-07 Jiong Chen, Yuan-Yuan Zhu, Lu Huang, Shuang-Shuang Zhang, Shuang-Xi Gu
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Corrigendum to “Structure and biological properties of mixed-ligand Cu(II) Schiff base complexes as potential anticancer agents”[Eur. J. Med. Chem. 134 (2017) 207–217]> Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-02-06 Yi Gou, Jinlong Li, Boyi Fan, Bohui Xu, Min Zhou, Feng Yang
The authors regret the misuse of Fig. 6B.
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Design, synthesis, and biological evaluation of quinazolinone-dihydropyrimidinone as a potential anti-diabetic agent via GLUT4 translocation stimulation Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-02-06 Arvind Kumar Jaiswal, Ajay Kishor Kushawaha, , Alisha Ansari, Nikita Chhikara, , Sarita Katiyar, Ishbal Ahmad, Abhijit Deb Choudhury, Rabi Sankar Bhatta, Akhilesh K. Tamrakar, Koneni V. Sashidhara
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Advances in the development of phosphodiesterase 5 inhibitors Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-02-06 Tieqiang Zong, Xing Huang, Wei Zhou, Zhengyu Hu, Long Jin, Peng Zhan, Yuqing Zhao, Jinfeng Sun, Gao Li
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Identification of the first-in-class dual inhibitor targeting BAG3 and HSP70 proteins to disrupt multiple chaperone pathways Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-02-06 Dafne Ruggiero, Emis Ingenito, Eleonora Boccia, Vincenzo Vestuto, Gilda D'Urso, Alessandra Capuano, Agostino Casapullo, Stefania Terracciano, Giuseppe Bifulco, Gianluigi Lauro, Ines Bruno
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D-morphinan analogs with favorable pharmacokinetic profiles as dual-acting antidepressants Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-02-06 Jing Ji, Zhengtao Hu, Fuqiang Zheng, Jiefang Zheng, Jiaxin Cheng, Nuriddinov Zayniddin, Safomuddin Abduahadi, Guan Wang, Xudong Gong, Libiao Pan, Pengcheng Li, Jiangyu Zhao, Tianwen Hu, Weiliang Zhu, Jingshan Shen, Guanghui Tian, Haji Akber Aisa, Yang He
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Spirocyclic compounds as innovative tools in drug discovery for medicinal chemists Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-02-05 Marina T. Varela, Gleiston G. Dias, Luiz Fernando N. de Oliveira, Ramon G. de Oliveira, Francielle D. Aguiar, João Pedro Nogueira, Luiza R. Cruz, Luiz C. Dias
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Structure-based design, synthesis and biological evaluation of a novel d-amino acid-containing peptide inhibitor by blocking the RAD51-BRCA2 interaction for the treatment of kidney cancer Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-02-05 Jianjun Wang, Lixia Guan, Jun Wang, Shengnan Yin, Junyi Gao, Yan Zhang, Miao-Miao Niu, Jindong Li, Ying Li
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Design, synthesis and biological evaluation of dual CDK9/PARP inhibitors for the treatment of cancer Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-02-05 Jindi Huang, Ya He, Sumeng Chen, Ran Ren, Shipeng Zhang, Ji-Quan Zhang, Zhang Zhang, Tie-Gen Chen, Ling Wang
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Inorganic nanoparticles and blood-brain barrier modulation: Advancing targeted neurological therapies Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-02-05 Zahra Sadat Razavi, Fateme Sadat Razavi, Seyed Sina Alizadeh
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Anticancer activity promoted by ligand diversity in diiron thiocarbyne complexes Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-02-05 Ekatarina Mihajlović, Lorenzo Biancalana, Marija Mojić, Sanja Jelača, Lorenzo Chiaverini, Stefano Zacchini, Sanja Mijatović, Danijela Maksimović-Ivanić, Fabio Marchetti
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An updated review on the role of small molecules in mediating protein degradation Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-02-04 Zumei Wu, Yulong Li, Jinyun Dong, Jiang-Jiang Qin
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Advancing Src kinase inhibition: From structural design to therapeutic innovation - A comprehensive review Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-02-04 Yifeng Su, Kun Zhu, Jiahao Wang, Boyan Liu, Yue Chang, Degui Chang, Yaodong You
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From Dyrk1A inhibitors to a novel class of antiviral agents: Targeting Enterovirus EV-A71 with 2-aryl-substituted thiophene scaffolds Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-02-04 Parthiena M. Keddis, Tuong-Khanh My Tu, Hugo Scherer, Andreas M. Kany, Donia E. Hafez, Sarah S. Darwish, Ashraf H. Abadi, Anna K.H. Hirsch, Matthias Engel, Mostafa M. Hamed, Jim-Tong Horng, Mohammad Abdel-Halim
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Promising thiazolidinedione-thiazole based multi-target and neuroprotective hybrids for Alzheimer's disease: Design, synthesis, in-vitro, in-vivo and in-silico studies Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-02-03 Fahad Hussain, Ayesha Tahir, Hafiz Muzzammel Rehman, Yurong Wu, Muhammad Shah, Umer Rashid
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Synthesis and evaluation of novel ebselen derivatives as urease inhibitors for combating Helicobacter pylori infections Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-02-03 Weilong Cao, Feng Jin, Binzhuo Liu, Guangzhao Xu, Shanshan Jin, Zongqing Jia, Peng Peng, Weiguo Song, Fahui Li, Dingding Gao, Kairui Feng
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Discovery of 2,4-diaminopyrimidine derivatives as potent inhibitors of FAK capable of activating the Hippo pathway for the treatment of esophageal squamous cell carcinoma Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-02-02 Xiao Wang, Yin-Ru Li, Ji Wu, Jin-Bo Niu, Jian Song, Sai-Yang Zhang
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Design and synthesis of novel sulfur-substituted triptolide with the ability to induce autophagy through inhibition of SRSF1 expression Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-02-02 Xinyi Chen, Jichen Guan, Yuzhi Lin, Haowen Luo, Junyi Liu, Jie Ma, Chuangjun Li, Dongming Zhang, Yingda Zang, Fangfang Lai
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Discovery of BW710 as a potent, selective and orally bioavailable fibroblast growth factor receptor 2 (FGFR2) inhibitor Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-02-01 Bowen Yang, Qiuju Xun, Yuan Tian, Huiqiong Li, Pinglian Wu, Yang Zhou, Shaohua Chang, Zhen Wang, Ke Ding, Dawei Ma
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Synthesis and evaluation of triazole-containing aryl/acyloxy prodrugs of a BTN3A1 ligand Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-02-01 Umed Singh, Girija Pawge, Parker A. Kintigh, Joseph P. Sarno, Sarita Rani, Chia-Hung Christine Hsiao, Andrew J. Wiemer, David F. Wiemer
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Ultra-short lipopeptides containing d-amino acid exhibiting excellent stability and antibacterial activity against gram-positive bacteria Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-02-01 Jing Zou, Jiahui Wang, Luyang Gao, Wenjing Xue, Jingyi Zhu, Yun Zhang, Sanhu Gou, Hui Liu, Chao Zhong, Jingman Ni
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Research progress in DNA damage response (DDR)-targeting modulators: From hits to clinical candidates Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-01-31 Binbin Cheng, Zongbao Ding, Yimeng Hong, Yaping Wang, Yingxing Zhou, Jianjun Chen, Xiaopeng Peng, Chunlai Zeng
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Different chemical scaffolds bind to L-phe site in Mycobacterium tuberculosis Phe-tRNA synthetase Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-01-31 Priyanka Gade, Changsoo Chang, Denise S. Pryde, Daniel Fletcher, Sarah Niven, Luma Godoy Magalhaes, David Robinson, Jagmohan Saini, Peter E.G.F. Ibrahim, Barbara Forte, Jacek Wower, Michael J. Bodkin, Beatriz Baragaña, Ian H. Gilbert, Karolina Michalska, Andrzej Joachimiak
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Single or double lipid-modified ultra-short antimicrobial peptides for treating infections caused by resistant bacteria Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-01-31 Xu Ouyang, Tingting Yang, Beibei Li, Qingyang Xu, Jingying Zhang, Zufang Ba, Yao Liu, Yu Wang, Zhongwei Yu, Pengyi Yan, Bingqian Ren, Xueting Liu, Liru Yuan, Yuhuan Zhao, Yuhe Yang, Chao Zhong, Hui Liu, Yun Zhang, Sanhu Gou, Jingman Ni
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Construction and activity evaluation of novel CHS inhibitors against fungal infections Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-01-31 Shuai Yu, Shiying Zhang, Anli Zhang, Hongfen Han, Jun Han, Bin Sun
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Hit to lead optimization of the 4-trifluoromethylquinoline derivatives as novel SGK1 inhibitors with potent anti-prostate cancer activity Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-01-31 Cheng Li, Sha Cheng, Jia Yu, Qian Zheng, Gang Yu, Mei Xu, Xueling Meng, Xiaoping Zeng, Kun Liu, Bixue Xu, Heng Luo, Guangcan Xu
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Design and preclinical evaluation of 99mTc-Labeled dimer FAPI-46 derivatives as potential tumor radiotracers Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-01-30 Qing Ruan, Lina Diao, Zuojie Li, Dajie Ding, Peiwen Han, Yuhao Jiang, Guangxing Yin, Junhong Feng, Qianna Wang, Jianyong Jiang, Junbo Zhang
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Optimization of pyrazole/1,2,4-triazole as dual EGFR/COX-2 inhibitors: Design, synthesis, anticancer potential, apoptosis induction and cell cycle analysis Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-01-30 Nesma M. Kahk, Fatma E.A. Mohamed, Marwa M. Abdelhakeem, Rania B. Bakr
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Recent advances in the therapeutic insights of thiazole scaffolds as acetylcholinesterase inhibitors Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-01-30 Dina H. Dawood, Manal M. Anwar
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Cytotoxic pyrrole-based gold(III) chelates target human topoisomerase II as dual-mode inhibitors and interact with human serum albumin Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-01-30 Sheldon Sookai, Matthew Akerman, Mia Færch, Yasien Sayed, Orde Q. Munro
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Sialyl Lewis X (sLex):Biological functions, synthetic methods and therapeutic implications Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-01-30 Leyu Tang, Jiaxu Zhang, Nassima Oumata, Nathalie Mignet, Matthieu Sollogoub, Yongmin Zhang
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Corrigendum to “Applying molecular hybridization to design a new class of pyrazolo[3,4-d] pyrimidines as Src inhibitors active in hepatocellular carcinoma” [Eur. J. Med. Chem. 280 (2024) 116929] Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-01-30 Salvatore Di Maria, Raffaele Passannanti, Federica Poggialini, Chiara Vagaggini, Alessia Serafinelli, Elena Bianchi, Paolo Governa, Lorenzo Botta, Giovanni Maga, Emmanuele Crespan, Fabrizio Manetti, Elena Dreassi, Francesca Musumeci, Anna Carbone, Silvia Schenone
Table 1 showed several errors originated from the formatting issue. In addition, we noted a mistake in the structure of compound 7c reported in Fig. 3. The pyrazole nitrogen is substituted by a methyl group instead of 2-chloro-2-phenylethyl chain. We have now corrected the structure. These corrections do not alter the conclusions or the overall findings of the work. The authors would like to apologise