An iodine-mediated radical cyclization of o-vinylaryl isocyanides with disulfides or diselenides has been developed. The atom-economic reaction provides a method for regioselective construction of the 2-chalcogenated quinolines in 42-93% yields by incorporation of both chalcogen atoms of disulfides or diselenides into quinolines.

Chiral 2-hydroxy-4-arylbut-3-enoic acid derivatives are important precursors for the synthesis of angiotensin converting enzyme (ACE) inhibitors, such as enalapril, lisinopril, cilapril or benazepril. In this work, we take advantage of the unexplored promiscuous ketoreductase activity of Δ1-piperidine-2-carboxylate/Δ1-pyrroline-2-carboxylate reductase from Pseudomonas syringae pv. tomato DSM 50315

This study presents a method for the synthesis of thiazinopyrrole fused ring derivatives utilizing a ring-opening recombination strategy with benzothiazole salts. Thiazolium salts, aldehydes, and amines undergo a cascade cyclization reaction in a one-pot under the solvent conditions of ethanol.

Gold-catalyzed [5+1]-annulations between allenylacetals with diazo esters to form 1,3-disubstituted naphthoate derivatives are described. Notably, this reaction chemoselectivity is switched to 2,3-naphthoate products using HOTf catalyst. Mechanistic study of these reactions supports an acetal activation, in which oxoniums are formed initially, followed by attack of the allene, generating allyl cations

Short-chain dehydrogenases (SDRs) are powerful catalysts for the asymmetric reduction of prochiral ketones in pharmaceutical products. Herein, through gene mining and evolutionary analysis, we obtained two major types of SDRs (SDR-1 and SDR-2) for the enantioselective complementary reduction of N-Boc-piperidone, which gives the corresponding product (R)- or (S)-N-Boc-piperidol, an intermediate of the

A photo-induced metal-free radical hydroboration of various styrenes with NHC-borane has been developed, which can provide mono- and di-alkylated boranes in a selective manner. Besides, this strategy can also be applied to prepare di-functionalized boranes with two different alkyl groups. Mild reaction conditions and good functional groups compatibility were observed. Preliminary mechanism for this

Now, Mohammad Asadi and colleagues present Mo3P nanoparticles functionalized with 1-ethyl-3-methylimidazolium and coated with an anion-exchange ionomer as a catalyst for CO2RR to propane. In 1 M KOH, the researchers report at –0.8 V versus the reversible hydrogen electode (VRHE) a current density of — 395 mA cm–2 and a FE for propane of 91%, which is remarkable as propane is not commonly accessible

Now, Wang et al. present an intensified approach that combines PDH with chemical looping–selective hydrogen combustion under anaerobic conditions in a tandem manner. Their approach involves the use of a multifunctional material, ferric vanadate vanadium oxide (FeVO4–VOx). In this composite, VOx provides dehydrogenation sites, while the adjacent nanoscale FeVO4 acts as an oxygen carrier for the subsequent

Now, Steven G. Boxer and co-workers systematically enhanced the electric fields in the active site of horse liver alcohol dehydrogenase (LADH) to accelerate the rates of hydride transfer in the reverse reaction transforming aldehydes into alcohols. Hereby, LADH forms a ternary complex with a NADH cofactor and the substrate, whereby the enzyme’s active site Zn+2 and the serine residue at position 48

Reactivity of nitriles in a CoCl2-6H2O/dppe/Zn–catalyzed diyne–nitrile cycloaddition was explored through the competitive reactions of a diyne with two different nitriles, and it was found that cyanamides are good substrates, and the reaction yielded 2-aminopyridines. Notably, N-unsubstituted cyanamide (H2N–CN) could be used for the reaction with 1,6-diynes to afford the corresponding N-unsubstituted

Abstract not available

In this Activity article, Shenlong Zhao (professor at the National Center for Nanoscience and Technology), Lei Du (associate professor at Guangzhou University), Siyu Ye (professor at Guangzhou University and vice chair and chief technology officer at SinoHykey), and their collaborators exchange their views on the recent progress of, insights into, and applications of key materials for proton-exchange

In this Activity article, Lei Du (associate professor at Guangzhou University), Siyu Ye (professor at Guangzhou University and vice chair and chief technology officer at SinoHykey), Shenlong Zhao (professor at the National Center for Nanoscience and Technology), and their collaborators discuss the challenges and opportunities of key materials for proton-exchange membrane (PEM) water splitting from

In this issue of Chem Catalysis, Sytniczuk, Kajetanowicz, and Grela report on sterically tuned cyclic(alkyl)(amino)carbene (CAAC) ligands to protect the requisite Ru-methylidene ([Ru]=CH2) intermediate present during the ethenolysis of renewable fatty acid methyl esters (FAMEs). Surprising structural characteristics of the Ru-CAAC complexes result in a turnover number of up to 740,000 and sub-ppm catalyst

The commercial catalysts currently used to mitigate NOx emissions from diesel vehicles are based on copper-exchanged zeolites with the CHA and AEI structures. In this issue of Chem Catalysis, DeLuca et al. investigate how zeolite framework topology affects catalyst performance, providing new strategies for the design of improved materials.

In this issue of Chem Catalysis, Fañanás-Mastral and co-workers report on the development of desymmetrization of meso-dibromocycloalkenes by using a copper-catalyzed borylative coupling with alkynes via a catalytically generated boron-substituted alkenylcopper intermediate. This transformation gives access to a wide range of chiral cycloalkenes featuring stereodefined alkenyl boronate and bromide functionalities

In this issue of Chem Catalysis, Karabencheva-Christova and co-workers report the mechanistic elucidation of fat-mass and obesity-associated enzyme (FTO). Through comprehensive computational analysis, the FTO-catalyzed demethylation pathway and mechanism are examined. Additionally, how key mutations affect enzyme catalysis is also investigated.

Recently in Science, Yang and co-workers reported a novel biocatalytic method to access valuable noncanonical amino acids (ncAAs) in a single operation. This unique reaction mode that was previously not known in biochemistry and organic chemistry was realized through the synergistic merger of photoredox catalysis and pyridoxal 5′-phosphate (PLP) biocatalysis.

Chlorine evolution reaction (CER) is the heart of the chlor-alkali process. A pivotal prerequisite for enabling cost-effective and eco-friendly chemical synthesis lies in the proficiency of CER electrocatalyst. Recent significant research by Cho et al. introduces platinum single-atom catalysts, illuminating a promising path to enhance the catalytic activity of CER.

The authors retract the article due to fabricated data presented in Scheme 2, Scheme 3, Scheme 4, Scheme 5a-5c, Table 1, and Table 2. As a result, the data and the conclusions of the paper are considered unreliable. The original article was published on October 17, 2019, and retracted on September 21,2023. This article has not yet been cited by other publications.