Establishing the protein posttranslational modification (PTM) landscape at the proteome scale relies on the target specificity of the relevant enzyme catalysts. Su et al. [ ACS Catal. 2021, 11, 14877] proposed that “the kcat/Km value is not the best parameter to determine the in vivo substrate specificity of an enzyme. Instead, the binding affinities of substrates are more important for determining

The reaction of phosphorus(III) esters with pinacolborane generates phosphines via the action of an NHC-copper(I) catalyst. This gives access, within minutes, to 12 P–H bonded species, including secondary and primary phosphines as well as PH3, in excellent conversions. These phosphines can be subsequently applied in the copper(I)-catalyzed hydrophosphination of heterocumulenes in a telescoped, one-pot

A cascade C-H activation, annulation and etherification protocol of N-hydroxybenzamides with propargylamines provides a flexible and powerful route to N-alkoxylated 3-arylisoindolin-1-ones. Three new bonds (C-C, C-N, and C-O) are generated to afford a series of isoindolin-1-ones bearing a tetrasubstituted carbon in 49% to 82% yields. The utility of this method is showcased by gram-scale synthesis,

Chemical recycling of synthetic polymers represents a promising strategy to deconstruct plastic waste and make valuable products. Inspired by small-molecule C–H bond activation, a visible-light-driven reaction is developed to deconstruct polystyrene (PS) into ∼40% benzoic acid as well as ∼20% other monomeric aromatic products at 50 °C and ambient pressure. The practicality of this strategy is demonstrated

The use of alkynes as vinylmetal pronucleophiles in intermolecular enantioselective metal-catalyzed carbonyl and imine reductive couplings to form allylic alcohols and amines is surveyed. Related hydrogen autotransfer processes, wherein alcohols or amines serve dually as reductants and carbonyl or imine proelectrophiles, also are cataloged, as are applications in target-oriented synthesis. These processes

The reaction of non-fluorinated silyl enol ether with alkyne is useful for the synthesis of β,γ-unsaturated carbonyl compounds. However, most of the existing methods for realizing such organic transformation usually employ stoichiometric amounts of relatively expensive Lewis acids/metallic salts. Herein, an iron(III)-catalyzed difluoroalkylation of aryl alkynes with difluoroenol silyl ether was developed

An electrochemical oxidative C-H/S-H cross-coupling reaction between acetonitrile and heteroaryl thiols has been developed. Me4NBr is employed as a redox catalyst to oxidize both the Csp3-H of acetonitrile and S-H of heteroaryl thiols. Heteroaryl vinyl sulfides were afforded under metal-free and oxidant-free reaction conditions in good yields and stereoselectivities with excellent functional group

We present an efficient method for forming C-N bonds via intramolecular amidation catalyzed by well-defined Cp*Co(N,O)I complexes. The reaction has been operate under mild conditions and produced a regioselective amidation product without the use of a bulky anion or expensive fluorinated solvents. The Cp*Co(N,O)-I catalyst is very effective for intramolecular benzylic, tertiary, and internal C(sp3)-H

Anion exchange membrane fuel cells (AEMFCs) have recently shown excellent progress in terms of their performance – e.g., achievable power and current density. However, very few AEMFCs have been demonstrated with the ability to operate for a long duration (>1000 h). In addition, it is unknown whether performance losses observed during operation are reversible, irreversible, or a combination of the two

A Pt–Ni–Co catalyst was synthesized with Pt single atoms and atomic clusters (SAACs) dispersed over (Ni,Co)(OH)2 nanoparticles on a carbon matrix, which leads to high catalytic activity, up to 100% conversion, and selectivity in the hydrogenation of nitroaromatics under moderate conditions (H2 ∼ 1.0 MPa and ≤40 °C). A synergistically coordinated ensemble effect of the Pt SAACs is identified with the

Axially chiral indole-based frameworks occur in natural products, bioactive molecules, and chiral ligands. Thus, the development of catalytic asymmetric atroposelective approaches for de novo construction of these frameworks is highly valuable. Here, the atroposelective organo/metal combined dual catalysis strategy for de novo construction of valuable axially chiral indole frameworks has been developed

Evidence is provided for a previously unknown proton-coupled electron transfer (PCET) mechanism for nitric oxide (NO) release from endogenous S-Nitrosoglutathione (GSNO) catalyzed by the metal–organic framework (MOF) H3[(Cu4Cl)3(BTTri)8] (CuBTTri) in the presence of glutathione (GSH). The balanced reaction stoichiometry, active site characterization, and the experimental rate law are used to systematically

This work presents a new strategy to enhance the charge transfer from Zr atoms in UiO-66 to black phosphorus (BP) via an atomic-level charge-transfer channel provided by Zr–P bonds for photocatalytic degradation of toluene and o-dichlorobenzene. The formation of Zr–P bonds is the key to covering BP with the UiO-66 encapsulation layer and improving the charge-transfer capability of BP–UiO, which is

While alkynyl silanes are ubiquitously employed in synthetic handles, especially in the build-up of more complex alkynes, such as alkyne-based polyaromatic materials, the identification of a similar robust functionality with ideally orthogonal reactivity space would greatly expand the modularity and scope in the construction of functional alkynes. We herein disclose the efficient, mild, and modular

The water–gas shift reaction (WGSR) is important in industries because it can reduce the CO content of syngas to produce purified H2, which can be used as fuel or to make ammonia (NH3). Supported noble metal catalysts have been widely studied for the WGSR because they exhibit high reactivity. However, the role of a metal–support interface in the WGSR has not yet been revealed and remains elusive. Density

Nanostructured metal oxides, such as Cu2O, CeO2, α-Fe2O3, and TiO2, can efficiently mediate photocatalysis for solar-to-chemical energy conversion and pollution remediation. In this contribution, we report a novel approach, dielectric Mie resonance-enhanced photocatalysis, to enhance the catalytic activity of metal oxide photocatalysts. Specifically, we demonstrate that Cu2O nanostructures exhibiting

The rising demand for regioselective protein modifications in chemical biology and pharmaceutical manufacturing has fueled efforts to develop diverse techniques that functionalize native amino acid residues. Although many powerful strategies have provided elegant solutions for functionalizing N-termini and side chains, sequence-unconstrained versatile C-terminal functionalization remains a challenge

Catalytic transformations are critical in a variety of thermal and electrochemical processes, including fuel and chemical generation, energy conversion, and decarbonization. Historically, various static assessment factors have been used to examine a wide range of catalytic materials. Surface, interfacial, and nanoscale phenomena have been seen in various catalytic disciplines, which are crucial to

The fluxional interconversion of a catalyst between forms with different structures and properties complicates mechanistic analyses and kinetic modeling efforts. We construct a simple model for a catalyst with two fluxionally interconverting forms, inspired by the interconverting flat (*) and stacked (▲) forms of noble metal sub-nanoclusters. Using a detailed balance, free energy relations, non-dimensionalization

The supported transition metal oxides, chlorides, carbides, and so forth (MXn), represent an important type of catalyst for redox processes. The MXn–support interaction, analogous to metal-support interaction, plays a critical role in redox reactions. Herein, we illustrated the nature of the monolayer CuCl2–γ-Al2O3 interaction, and its catalytic consequence induced by support facets in ethylene oxychlorination

We herein developed a protocol for the asymmetric synthesis of artificial AAs featuring a 3-spiropyrrolidine oxindole skeletal with continuous tetrasubstituted carbon stereocenters by a 1,3-dipolar cycloaddition reaction of in situ generated azomethine ylides with a chiral dehydroalanine Ni(II) complex. A three-component reaction of the Ni(II) complex with various isatins and AAs in green solvent (ethanol)

The widely investigated oxygen reduction reaction (ORR) is well-known to proceed via two competing routes, involving two or four electrons, and yielding different reaction products, respectively. Both pathways are believed to share a common, elusive intermediate, namely, the hydroperoxyl radical. By exploiting a cobalt single-atom biomimetic model catalyst, based on a self-assembled monolayer of Co-porphyrins

A transition-metal-free aminocyanation of aryl alkynes has been achieved using indium tribromide, InBr3 or B(C6F5)3 as a Lewis acid. This aminocyanation protocol features with non-toxic cyanide source, a good substrate scope and valuable aminocyanation products. Mechanistic studies reveal the complex formation between Lewis acid and alkyne to produce in situ alkyne nitrile as a key intermediate. Further