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Designer proteins take the bite out of snake venom Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-02-06
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Peptide blocks phase separation and oncogenic transcription Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-02-05
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Voltage-gated sodium channels in excitable cells as drug targets Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-02-03 Matthew Alsaloum, Sulayman D. Dib-Hajj, Dana A. Page, Peter C. Ruben, Adrian R. Krainer, Stephen G. Waxman
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PKC modulator promotes remyelination Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-02-03
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New target to tackle coronaviruses Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-02-03
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Novel strategies to manage CAR-T cell toxicity Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-02-03 Arthur Mulvey, Lionel Trueb, George Coukos, Caroline Arber
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The multiple myeloma drug market Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-01-31
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Degrading aurora kinase A in neuroblastoma Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-01-31
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Designing proteins targeting neosurfaces Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-01-31
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FDA approves new non-opioid pain drug Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-01-30
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Enhancing immunity during ageing by targeting interactions within the tissue environment Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-01-28 Olivia V. Bracken, Roel P. H. De Maeyer, Arne N. Akbar
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FGF-based drug discovery: advances and challenges Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-01-28 Gaozhi Chen, Lingfeng Chen, Xiaokun Li, Moosa Mohammadi
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J&J buys Intra-Cellular Therapies for US$14.6 billion, expanding its neuroscience portfolio Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-01-22
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Base editing reduces prion protein Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-01-22
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2024 FDA approvals exceed average number but have lower sales projections Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-01-17
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Biopharma dealmaking in 2024 Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-01-15
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Outlook for medicines development and use in 2025 Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-01-15 Sarah Rickwood, Helena Bayley, Stefan Lutzmayer, Meike Madelung, Markus Gores
Oncology innovations, obesity medicines, an uptick for mergers and acquisitions, regulation for artificial intelligence applications and growing consumerization are expected to be key topics.
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Targeting mitophagy in neurodegenerative diseases Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-01-14 Odetta Antico, Paul W. Thompson, Nicholas T. Hertz, Miratul M. K. Muqit, Laura E. Parton
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Targeting inherited mutations to prevent metastasis Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-01-13
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DLL3 draws two antibody–drug conjugate deals Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-01-13
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FDA approves next-generation triple therapy for cystic fibrosis Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-01-13
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Cough suppressant reverses lung scarring Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-01-10
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DNA-PKcs inhibitor causes genomic alterations Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-01-10
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Human brain organoids identify glioma inhibitors Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-01-10
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Sodium channel blocker reduces skin inflammation Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-01-10
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Engineered T cells traverse new terrain Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-01-08
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Lipid nanoparticle ferries therapeutic mRNA to the placenta Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-01-07
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Functional dynamics of G protein-coupled receptors reveal new routes for drug discovery Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-01-02 Paolo Conflitti, Edward Lyman, Mark S. P. Sansom, Peter W. Hildebrand, Hugo Gutiérrez-de-Terán, Paolo Carloni, T. Bertie Ansell, Shuguang Yuan, Patrick Barth, Anne S. Robinson, Christopher G. Tate, David Gloriam, Stephan Grzesiek, Matthew T. Eddy, Scott Prosser, Vittorio Limongelli
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2024 FDA approvals Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-01-02
The FDA approved 50 new therapeutics in 2024, with green lights for a novel schizophrenia drug, a first NASH medicine and much more.
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FDA approves first HER2 × HER3 bispecific antibody Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2024-12-18
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Pairing up with GLP-1 to combat obesity Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2024-12-18
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Open Targets: 10 years of partnership in target discovery Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2024-12-17 David G. Hulcoop, Gosia Trynka, Ellen M. McDonagh
The Open Targets consortium was founded in 2014 to translate insights from genetics and functional genomics into identifying and prioritizing therapeutic targets. We highlight key achievements and insights stemming from this partnership of academic and industry scientists.
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Chemical engineering of CRISPR–Cas systems for therapeutic application Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2024-12-17 Halle M. Barber, Adrian A. Pater, Keith T. Gagnon, Masad J. Damha, Daniel O’Reilly
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Harnessing the biology of regulatory T cells to treat disease Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2024-12-16 Christine M. Wardell, Dominic A. Boardman, Megan K. Levings
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IRDiRC perspectives on the application of digital biomarkers in therapeutic development for rare diseases Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2024-12-16 Rajesh Krishna, Anneliene H. Jonker, Thomas Morel, Ken Sakushima, Anna M. G. Pasmooij, Daniel O’Connor
New approaches are needed to streamline clinical trials of drugs for patients with rare diseases. Digital biomarkers offer one such approach, but several challenges must be addressed to realize their potential.
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Targeting metabolic dysfunction of CD8 T cells and natural killer cells in cancer Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2024-12-12 Sébastien Viel, Eric Vivier, Thierry Walzer, Antoine Marçais
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NaV1.8 inhibitor poised to provide opioid-free pain relief Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2024-12-12
Vertex’s first-in-class suzetrigine could soon usher in a new class of analgesic.
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Upcoming FDA approval decisions in Q1 2025 Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2024-12-11
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Top product forecasts for 2025 Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2024-12-10
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Can non-canonical amino acids open up non-canonical drug discovery opportunities? Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2024-12-09
Jason Chin, head of Cambridge’s Centre for Chemical & Synthetic Biology and CSO of Constructive Bio, discusses the role for unnatural amino acids in biologic therapies.
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Showing tau the exit Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2024-12-05
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FDA approves first menin inhibitor, for acute leukaemia Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2024-12-03
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Covalent inhibitor engages oncogenic AKT kinase Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2024-12-03
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Vaccines for cancer prevention: exploring opportunities and navigating challenges Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2024-12-02 Michele Graciotti, Lana E. Kandalaft
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Antiviral target compound profile for pandemic preparedness Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2024-12-02 James F. Demarest, Ruxandra Draghia-Akli, Tomas Cihlar, Kenneth Bradley, John A. T. Young, Richa Chandra, Sujata Vaidyanathan, Margaret Chu-Moyer, Christopher L. Lynch, Andrew Campbell, Kumar Singh Saikatendu, John P. Bilello, Yoshihiko Murata, Marnix van Loock, Aeron C. Hurt, Timothy Tellinghuisen, Lee Ruggiero, Richard Mackman, Nina M. Hill, John C. Pottage
The recent experiences with the pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have demonstrated the urgent need for a structured approach towards accelerated and more effective discovery, development and delivery of vaccines, therapeutics, and diagnostics to minimize the overall impact of the next pandemic (see Related links). This urgency is further highlighted
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Therapeutic landscape of metabolic dysfunction-associated steatohepatitis (MASH) Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2024-11-28 Albert Do, Frhaan Zahrawi, Wajahat Z. Mehal
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Understanding cholestatic itch Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2024-11-27
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The targeted protein degradation landscape Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2024-11-27
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Author Correction: Drugging the NLRP3 inflammasome: from signalling mechanisms to therapeutic targets Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2024-11-27 Lieselotte Vande Walle, Mohamed Lamkanfi
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Expanding the ligandable proteome Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2024-11-27
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ENGases to treat IgG-mediated diseases Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2024-11-27
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Multi-TACs target solid tumours Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2024-11-27
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FDA approves first biparatopic antibody therapy Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2024-11-26
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Author Correction: B cell depletion therapies in autoimmune disease: advances and mechanistic insights Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2024-11-26 Dennis S. W. Lee, Olga L. Rojas, Jennifer L. Gommerman
Correction to: Nature Reviews Drug Discovery https://doi.org/10.1038/s41573-020-00092-2, published online 15 December 2020.
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FDA approves second TTR stabilizer for cardiac amyloidosis Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2024-11-25
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StitchR platform joins up gene therapy payloads Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2024-11-22
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Targeting lysine acetylation readers and writers Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2024-11-21 Ming-Ming Zhou, Philip A. Cole
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NK2R agonist delivers one-two punch to obesity Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2024-11-21
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FDA approves l-amino acid decarboxylase deficiency gene therapy Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2024-11-15
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Senescence as a therapeutic target in cancer and age-related diseases Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2024-11-15 Domhnall McHugh, Imanol Durán, Jesús Gil