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Synthetic biomolecular condensates enhance translation from a target mRNA in living cells Nat. Chem. (IF 19.2) Pub Date : 2025-02-10 Daniel Mark Shapiro, Sonal Deshpande, Seyed Ali Eghtesadi, Miranda Zhong, Cassio Mendes Fontes, David Fiflis, Dahlia Rohm, Junseon Min, Taranpreet Kaur, Joanna Peng, Max Ney, Jonathan Su, Yifan Dai, Aravind Asokan, Charles A. Gersbach, Ashutosh Chilkoti
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Efficient and modular synthesis of ibogaine and related alkaloids Nat. Chem. (IF 19.2) Pub Date : 2025-02-06 Rishab N. Iyer, David Favela, Andras Domokos, Guoliang Zhang, Arabo A. Avanes, Samuel J. Carter, Andrian G. Basargin, Alexis R. Davis, Dean J. Tantillo, David E. Olson
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Isotopic labelling of water reveals the hydrogen transfer route in electrochemical CO2 reduction Nat. Chem. (IF 19.2) Pub Date : 2025-02-06 Jiguang Zhang, Chengyi Zhang, Meng Wang, Yu Mao, Bo Wu, Qin Yang, Bingqing Wang, Ziyu Mi, Mingsheng Zhang, Ning Ling, Wan Ru Leow, Ziyun Wang, Yanwei Lum
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Molecular contacts with an orthogonal π-skeleton induce amorphization to enhance perovskite solar cell performance Nat. Chem. (IF 19.2) Pub Date : 2025-02-06 Jingjing Zhou, Yixin Luo, Runda Li, Liuwen Tian, Ke Zhao, Jiahui Shen, Donger Jin, Zixuan Peng, Libing Yao, Li Zhang, Qingqing Liu, Shaochen Zhang, Lu Jin, Shenglong Chu, Sisi Wang, Yuan Tian, Jiazhe Xu, Xu Zhang, Pengju Shi, Xiaonan Wang, Wei Fan, Xuechun Sun, Jingyi Sun, Luo-Zhou Chen, Gang Wu, Wen Shi, Hong-Fei Wang, Tianqi Deng, Rui Wang, Deren Yang, Jingjing Xue
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Mn12 and the dawn of single-molecule magnets Nat. Chem. (IF 19.2) Pub Date : 2025-02-05 Niki Mavragani, Muralee Murugesu
Niki Mavragani and Muralee Murugesu discuss the discovery, structure and properties of Mn12, a prototypical single-molecule magnet.
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Eric the AI research assistant for chemists Nat. Chem. (IF 19.2) Pub Date : 2025-02-05 Bruce C. Gibb
Artificial intelligence is being used in many aspects of chemical research. Bruce Gibb discusses top-down and bottom-up approaches to the development of AI, highlighting the issues with cultural divides and the challenges of data quality. He also introduces 'Eric', a potential AI research assistant for the future chemist.
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Protons undermine lithium-ion batteries with positively disastrous results Nat. Chem. (IF 19.2) Pub Date : 2025-01-29 Noah P. Holzapfel, Veronica Augustyn
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Enantioselective synthesis of 2-substituted bicyclo[1.1.1]pentanes via sequential asymmetric imine addition of bicyclo[1.1.0]butanes and skeletal editing Nat. Chem. (IF 19.2) Pub Date : 2025-01-28 Jin-Teng Che, Wei-Yi Ding, Hong-Bo Zhang, Yong-Bin Wang, Shao-Hua Xiang, Bin Tan
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Supramolecular dyads as photogenerated qubit candidates Nat. Chem. (IF 19.2) Pub Date : 2025-01-27 Ivan V. Khariushin, Philipp Thielert, Elisa Zöllner, Maximilian Mayländer, Theresia Quintes, Sabine Richert, Andreas Vargas Jentzsch
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Computational design of highly signalling-active membrane receptors through solvent-mediated allosteric networks Nat. Chem. (IF 19.2) Pub Date : 2025-01-23 K.-Y. M. Chen, J. K. Lai, L. S. P. Rudden, J. Wang, A. M. Russell, K. Conners, M. E. Rutter, B. Condon, F. Tung, L. Kodandapani, B. Chau, X. Zhao, J. Benach, K. Baker, E. J. Hembre, P. Barth
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A living library concept to capture the dynamics and reactivity of mixed-metal clusters for catalysis Nat. Chem. (IF 19.2) Pub Date : 2025-01-23 Raphael Bühler, Max Schütz, Karla F. Andriani, Marcos G. Quiles, João Paulo A. de Mendonça, Vivianne K. Ocampo-Restrepo, Johannes Stephan, Sophia Ling, Samia Kahlal, Jean-Yves Saillard, Christian Gemel, Juarez L. F. Da Silva, Roland A. Fischer
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Mesoporous single-crystal metal–organic frameworks Nat. Chem. (IF 19.2) Pub Date : 2025-01-22 Yingji Zhao, Yusuke Yamauchi
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Publisher Correction: Protocells by spontaneous reaction of cysteine with short-chain thioesters Nat. Chem. (IF 19.2) Pub Date : 2025-01-21 Christy J. Cho, Taeyang An, Yei-Chen Lai, Alberto Vázquez-Salazar, Alessandro Fracassi, Roberto J. Brea, Irene A. Chen, Neal K. Devaraj
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Author Correction: Cytoskeleton-functionalized synthetic cells with life-like mechanical features and regulated membrane dynamicity Nat. Chem. (IF 19.2) Pub Date : 2025-01-21 Sebastian Novosedlik, Felix Reichel, Thijs van Veldhuisen, Yudong Li, Hanglong Wu, Henk Janssen, Jochen Guck, Jan van Hest
Correction to: Nature Chemistry https://doi.org/10.1038/s41557-024-01697-5, published online 3 January 2025.
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Author Correction: Discovery of the selenium-containing antioxidant ovoselenol derived from convergent evolution Nat. Chem. (IF 19.2) Pub Date : 2025-01-21 Chase M. Kayrouz, Kendra A. Ireland, Vanessa Y. Ying, Katherine M. Davis, Mohammad R. Seyedsayamdost
Correction to: Nature Chemistry https://doi.org/10.1038/s41557-024-01600-2, published online 14 August 2024.
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Light-promoted aromatic denitrative chlorination Nat. Chem. (IF 19.2) Pub Date : 2025-01-20 Tiantian Liang, Zhen Lyu, Ye Wang, Wenyan Zhao, Ruocheng Sang, Gui-Juan Cheng, Fei Ye
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Synthesis of pillar-layered metal–organic frameworks with variable backbones through sequence control Nat. Chem. (IF 19.2) Pub Date : 2025-01-20 Jingjing Yuan, Ming Yang, Bin Yang, Shuting Chen, Zhiqiang Liu, Qingqing Pang, Mingyu Wan, Anmin Zheng, Binbin Tu
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An open-shell Ir(II)/Ir(IV) redox couple outperforms an Ir(I)/Ir(III) pair in olefin isomerization Nat. Chem. (IF 19.2) Pub Date : 2025-01-20 Alejandra Pita-Milleiro, Nereida Hidalgo, Juan J. Moreno, Israel Fernández, Jesús Campos
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Isolation of a planar π-aromatic Bi5− ring in a cobalt-based inverse-sandwich-type complex Nat. Chem. (IF 19.2) Pub Date : 2025-01-20 Julia Rienmüller, Benjamin Peerless, Sagar Paul, Florian Bruder, Wolfgang Wernsdorfer, Florian Weigend, Stefanie Dehnen
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Vibrational weak and strong coupling modify a chemical reaction via cavity-mediated radiative energy transfer Nat. Chem. (IF 19.2) Pub Date : 2025-01-16 Zachary T. Brawley, Sindhana Pannir-Sivajothi, Ju Eun Yim, Yong Rui Poh, Joel Yuen-Zhou, Matthew Sheldon
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The mechanism of amyloid fibril growth from Φ-value analysis Nat. Chem. (IF 19.2) Pub Date : 2025-01-16 Jacob Aunstrup Larsen, Abigail Barclay, Nicola Vettore, Louise K. Klausen, Lena N. Mangels, Alberto Coden, Jeremy D. Schmit, Kresten Lindorff-Larsen, Alexander K. Buell
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Engineering a DNA polymerase for modifying large RNA at specific positions Nat. Chem. (IF 19.2) Pub Date : 2025-01-13 Dian Chen, Zhanghui Han, Xiaoge Liang, Yu Liu
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Coacervate vesicles assembled by liquid–liquid phase separation improve delivery of biopharmaceuticals Nat. Chem. (IF 19.2) Pub Date : 2025-01-13 Ping Wen, Hanwei Huang, Ruizhe Zhang, Hanqi Zheng, Tingxizi Liang, Chuyue Zhuang, Qing Wu, Junxia Wang, Feng Liu, Ke Zhang, Wei Wu, Kaixin He, Funan Liu, Hongjun Li, Zhen Gu
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Defining proteoform-specific interactions for drug targeting in a native cell signalling environment Nat. Chem. (IF 19.2) Pub Date : 2025-01-13 Corinne A. Lutomski, Jack L. Bennett, Tarick J. El-Baba, Di Wu, Joshua D. Hinkle, Sean A. Burnap, Idlir Liko, Christopher Mullen, John E. P. Syka, Weston B. Struwe, Carol V. Robinson
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Mimicking of differentiation in pluripotent synthetic cells Nat. Chem. (IF 19.2) Pub Date : 2025-01-10
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Self-assembly of chiroptical ionic co-crystals from silver nanoclusters and organic macrocycles Nat. Chem. (IF 19.2) Pub Date : 2025-01-08 Yingwei Li, Grant J. Stec, Hong Ki Kim, Surendra Thapa, Shao-Liang Zheng, Arthur McClelland, Jarad A. Mason
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A pseudo-cubic metal–organic cage with conformationally switchable faces for dynamically adaptive guest encapsulation Nat. Chem. (IF 19.2) Pub Date : 2025-01-08 Houyang Xu, Tanya K. Ronson, Andrew W. Heard, Paula C. P. Teeuwen, Laura Schneider, Philipp Pracht, John D. Thoburn, David J. Wales, Jonathan R. Nitschke
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Synthesis of three-dimensional covalent organic frameworks through a symmetry reduction strategy Nat. Chem. (IF 19.2) Pub Date : 2025-01-08 Jianhong Chang, Zeyue Zhang, Haorui Zheng, Hui Li, Jinquan Suo, Chunqing Ji, Fenqian Chen, Shipeng Zhang, Zitao Wang, Valentin Valtchev, Shilun Qiu, Junliang Sun, Qianrong Fang
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Accelerating stereoselective radical cross-couplings Nat. Chem. (IF 19.2) Pub Date : 2025-01-07 Gregory R. Alvey, David L. Avetian, Markus D. Kärkäs
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Practical electronics and robotics for chemists Nat. Chem. (IF 19.2) Pub Date : 2025-01-07 Pawel L. Urban
To the Editor — McCluskey and colleagues recently emphasized the importance of computers and coding in chemical education1. I propose that efforts to enhance programming skills should be complemented by teaching chemistry students the fundamentals of electronics and robotics. Although it is imaginable to address such skill gaps with collaborations, they are often hard to establish and maintain, owing
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Remote control of chirality in hybrid perovskite materials Nat. Chem. (IF 19.2) Pub Date : 2025-01-07 Ghewa AlSabeh, Mengqiong Zhu, Jovana V. Milić
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Porphyrins are nature’s workhorse Nat. Chem. (IF 19.2) Pub Date : 2025-01-07 Paulina Krzyszowska, Ewa Pacholska-Dudziak
Paulina Krzyszowska and Ewa Pacholska-Dudziak recap the history of porphyrins, their biological relevance, and discuss examples of their use in modern applications.
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Beyond grateful Nat. Chem. (IF 19.2) Pub Date : 2025-01-07 Michelle Francl
The acknowledgements sections of papers are used formally to recognize those who have contributed to an article but are not authors. Michelle Francl suggests that they can be more than that — they can say more than thank you and can flesh out a story.
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De novo design of ribosomally synthesized and post-translationally modified peptides Nat. Chem. (IF 19.2) Pub Date : 2025-01-07 Emerson Glassey, Zhengan Zhang, Andrew M. King, David L. Niquille, Christopher A. Voigt
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Synthesis of single-crystalline sp2-carbon-linked covalent organic frameworks through imine-to-olefin transformation Nat. Chem. (IF 19.2) Pub Date : 2025-01-06 Shengxu Li, Shunqi Xu, En Lin, Tonghai Wang, Haoyong Yang, Junyi Han, Yuxiang Zhao, Qunji Xue, Paolo Samorì, Zhenjie Zhang, Tao Zhang
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A trimetallic bismuth(I)-based allyl cation Nat. Chem. (IF 19.2) Pub Date : 2025-01-06 Davide Spinnato, Nils Nöthling, Markus Leutzsch, Maurice van Gastel, Lucas Wagner, Frank Neese, Josep Cornella
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Intellectual frameworks to understand complex biochemical systems at the origin of life Nat. Chem. (IF 19.2) Pub Date : 2025-01-06 Burckhard Seelig, Irene A. Chen
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Uniform single-crystal mesoporous metal–organic frameworks Nat. Chem. (IF 19.2) Pub Date : 2025-01-06 Zirui Lv, Runfeng Lin, Yi Yang, Kun Lan, Chin-Te Hung, Pengfei Zhang, Jinxiu Wang, Wanhai Zhou, Zaiwang Zhao, Zhongyao Wang, Jiawen Zou, Taoyang Wang, Tiancong Zhao, Yifei Xu, Dongliang Chao, Weimin Tan, Bo Yan, Qiaowei Li, Dongyuan Zhao, Xiaomin Li
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Stereoselective amino alcohol synthesis via chemoselective electrocatalytic radical cross-couplings Nat. Chem. (IF 19.2) Pub Date : 2025-01-03 Jiawei Sun, Shuanghu Wang, Kaid C. Harper, Yu Kawamata, Phil S. Baran
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Synthesis of tertiary alkyl amines via photoinduced copper-catalysed nucleophilic substitution Nat. Chem. (IF 19.2) Pub Date : 2025-01-03 Hyungdo Cho, Xiaoyu Tong, Giuseppe Zuccarello, Robert L. Anderson, Gregory C. Fu
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Cytoskeleton-functionalized synthetic cells with life-like mechanical features and regulated membrane dynamicity Nat. Chem. (IF 19.2) Pub Date : 2025-01-03 Sebastian Novosedlik, Felix Reichel, Thijs van Veldhuisen, Yudong Li, Hanglong Wu, Henk Janssen, Jochen Guck, Jan van Hest
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Four-electron reduction of benzene by a samarium(ii)-alkyl without the addition of external reducing agents Nat. Chem. (IF 19.2) Pub Date : 2025-01-03 Georgia M. Richardson, Thayalan Rajeshkumar, Finlay M. Burke, Scott A. Cameron, Brooke D. Nicholls, Joanne E. Harvey, Robert A. Keyzers, Tane Butler, Simon Granville, Lujia Liu, Julien Langley, Li F. Lim, Nicholas Cox, Nicholas F. Chilton, Jamie Hicks, Nathaniel J. L. K. Davis, Laurent Maron, Mathew D. Anker
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In situ nonlinear optical spectroscopy for probing buried oxide–water interfaces Nat. Chem. (IF 19.2) Pub Date : 2025-01-02
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Adaptive metal ion transport and metalloregulation-driven differentiation in pluripotent synthetic cells Nat. Chem. (IF 19.2) Pub Date : 2024-12-23 Sayuri L. Higashi, Yanjun Zheng, Taniya Chakraborty, Azadeh Alavizargar, Andreas Heuer, Seraphine V. Wegner
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Molecular basis for the diversification of lincosamide biosynthesis by pyridoxal phosphate-dependent enzymes Nat. Chem. (IF 19.2) Pub Date : 2024-12-06 Takahiro Mori, Yoshitaka Moriwaki, Kosuke Sakurada, Shuang Lyu, Stanislav Kadlcik, Jiri Janata, Aninda Mazumdar, Marketa Koberska, Tohru Terada, Zdenek Kamenik, Ikuro Abe
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Protein prediction takes the prize Nat. Chem. (IF 19.2) Pub Date : 2024-12-02 Stacey Paiva
The three-dimensional structure of a protein — as determined by its primary amino acid sequence — ultimately dictates how it can interact with other molecules and therefore governs its function, which could be, for example, catalysing a chemical transformation, transporting a molecule or providing structure. The capacity to accurately characterize a protein’s 3D structure directly from its primary
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Evolving learning styles Nat. Chem. (IF 19.2) Pub Date : 2024-12-02 Shira Joudan
In grad school, there is time to focus on learning about your field and your project — and to keep up with the literature. Now, as an assistant professor, Shira Joudan explains how learning science is necessarily different as they manage multiple projects and a busy schedule.
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The mystery of crotonyl-CoA Nat. Chem. (IF 19.2) Pub Date : 2024-12-02 Marinda Westerveld, Rita Petracca
Marinda Westerveld and Rita Petracca describe the current understanding of the biosynthesis of crotonyl-coenzyme A.
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Electrochemical formation of bis(fluorosulfonyl)imide-derived solid-electrolyte interphase at Li-metal potential Nat. Chem. (IF 19.2) Pub Date : 2024-12-02 Weilai Yu, Kuan-Yu Lin, David T. Boyle, Michael T. Tang, Yi Cui, Yuelang Chen, Zhiao Yu, Rong Xu, Yangju Lin, Guangxia Feng, Zhuojun Huang, Lukas Michalek, Weiyu Li, Stephen J. Harris, Jyh-Chiang Jiang, Frank Abild-Pedersen, Jian Qin, Yi Cui, Zhenan Bao
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DNA catch bonds demonstrate the art of getting stuck Nat. Chem. (IF 19.2) Pub Date : 2024-11-29 Russell J. Wilson, Kerstin G. Blank
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Phase separation and ageing of glycine-rich protein from tick adhesive Nat. Chem. (IF 19.2) Pub Date : 2024-11-29 Ketan A. Ganar, Manali Nandy, Polina Turbina, Chang Chen, Dennis Suylen, Elisa Nihoul, Emily Louise Pascoe, Stan van der Beelen, Maarten Plaum, Leendert van den Bos, Constantianus J. M. Koenraadt, Ingrid Dijkgraaf, Siddharth Deshpande
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Competitive exclusion among self-replicating molecules curtails the tendency of chemistry to diversify Nat. Chem. (IF 19.2) Pub Date : 2024-11-29 Marcel J. Eleveld, Yannick Geiger, Juntian Wu, Armin Kiani, Gaël Schaeffer, Sijbren Otto
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Mimicking fluorophores from nature to generate artificial fluorescent proteins and biosensors Nat. Chem. (IF 19.2) Pub Date : 2024-11-28 Chia-Heng Hsiung, Xin Zhang
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Designing artificial fluorescent proteins and biosensors by genetically encoding molecular rotor-based amino acids Nat. Chem. (IF 19.2) Pub Date : 2024-11-28 Liming Hu, Wenbing Cao, Yihaofan Jiang, Wenkang Cai, Xiaoding Lou, Tao Liu
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Asymmetric dearomative single-atom skeletal editing of indoles and pyrroles Nat. Chem. (IF 19.2) Pub Date : 2024-11-28 Xiaolong Zhang, Qingmin Song, Shaopeng Liu, Paramasivam Sivaguru, Zhaohong Liu, Yong Yang, Yongyue Ning, Edward A. Anderson, Graham de Ruiter, Xihe Bi
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Unmasking the reverse catalytic activity of ‘ene’-reductases for asymmetric carbonyl desaturation Nat. Chem. (IF 19.2) Pub Date : 2024-11-26 Hui Wang, Bin Gao, Heli Cheng, Shixuan Cao, Xinyi Ma, Yinjuan Chen, Yuxuan Ye
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The importance of integrating energy justice into chemistry graduate student research and the associated pathways and barriers Nat. Chem. (IF 19.2) Pub Date : 2024-11-25 Casey M. Davis, Lacey S. Roberts, Sasha R. Neefe, Ronan Kennedy, Karen Bailey, Kyri Baker, Daniel Kaffine, Michael F. Toney
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Cyclic amine ring expansion Nat. Chem. (IF 19.2) Pub Date : 2024-11-21 Jack M. Wootton, William P. Unsworth