当前期刊: Nature Go to current issue    加入关注   
显示样式:        排序: IF: - GO 导出
我的关注
我的收藏
您暂时未登录!
登录
  • SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls
    Nature (IF 42.778) Pub Date : 2020-07-15
    Nina Le Bert; Anthony T. Tan; Kamini Kunasegaran; Christine Y. L. Tham; Morteza Hafezi; Adeline Chia; Melissa Hui Yen Chng; Meiyin Lin; Nicole Tan; Martin Linster; Wan Ni Chia; Mark I-Cheng Chen; Lin-Fa Wang; Eng Eong Ooi; Shirin Kalimuddin; Paul Anantharajal Tambyah; Jenny Guek-Hong Low; Yee-Joo Tan; Antonio Bertoletti

    Memory T cells induced by previous pathogens can shape the susceptibility to, and clinical severity of, subsequent infections1. Little is known about the presence of pre-existing memory T cells in humans with the potential to recognize SARS-CoV-2. Here, we first studied T cell responses to structural (nucleocapsid protein, NP) and non-structural (NSP-7 and NSP13 of ORF1) regions of SARS-CoV-2 in COVID-19

    更新日期:2020-07-15
  • Fasting-mimicking diet and hormone therapy induce breast cancer regression
    Nature (IF 42.778) Pub Date : 2020-07-15
    Irene Caffa; Vanessa Spagnolo; Claudio Vernieri; Francesca Valdemarin; Pamela Becherini; Min Wei; Sebastian Brandhorst; Chiara Zucal; Else Driehuis; Lorenzo Ferrando; Francesco Piacente; Alberto Tagliafico; Michele Cilli; Luca Mastracci; Valerio G. Vellone; Silvano Piazza; Anna Laura Cremonini; Raffaella Gradaschi; Carolina Mantero; Mario Passalacqua; Alberto Ballestrero; Gabriele Zoppoli; Michele

    Approximately 75% of all breast cancers express the oestrogen and/or progesterone receptors. Endocrine therapy is usually effective in these hormone-receptor-positive tumours, but primary and acquired resistance limits its long-term benefit1,2. Here we show that in mouse models of hormone-receptor-positive breast cancer, periodic fasting or a fasting-mimicking diet3,4,5 enhances the activity of the

    更新日期:2020-07-15
  • Potently neutralizing and protective human antibodies against SARS-CoV-2
    Nature (IF 42.778) Pub Date : 2020-07-15
    Seth J. Zost; Pavlo Gilchuk; James Brett Case; Elad Binshtein; Rita E. Chen; Joseph P. Nkolola; Alexandra Schäfer; Joseph X. Reidy; Andrew Trivette; Rachel S. Nargi; Rachel E. Sutton; Naveenchandra Suryadevara; David R. Martinez; Lauren E. Williamson; Elaine C. Chen; Taylor Jones; Samuel Day; Luke Myers; Ahmed O. Hassan; Natasha M. Kafai; Emma S. Winkler; Julie M. Fox; Swathi Shrihari; Benjamin K.

    The COVID-19 pandemic is a major threat to global health1 for which there are limited medical countermeasures2,3. Moreover, we currently lack a thorough understanding of mechanisms of humoral immunity4. From a larger panel of human monoclonal antibodies (mAbs) targeting the spike (S) glycoprotein5, we identified several that exhibited potent neutralizing activity and fully blocked the receptor-binding

    更新日期:2020-07-15
  • The National Lung Matrix Trial of personalized therapy in lung cancer
    Nature (IF 42.778) Pub Date : 2020-07-15
    Gary Middleton; Peter Fletcher; Sanjay Popat; Joshua Savage; Yvonne Summers; Alastair Greystoke; David Gilligan; Judith Cave; Noelle O’Rourke; Alison Brewster; Elizabeth Toy; James Spicer; Pooja Jain; Adam Dangoor; Melanie Mackean; Martin Forster; Amanda Farley; Dee Wherton; Manita Mehmi; Rowena Sharpe; Tara C. Mills; Maria Antonietta Cerone; Timothy A. Yap; Thomas B. K. Watkins; Emilia Lim; Charles

    The majority of targeted therapies for non-small-cell lung cancer (NSCLC) are directed against oncogenic drivers that are more prevalent in patients with light exposure to tobacco smoke1,2,3. As this group represents around 20% of all patients with lung cancer, the discovery of stratified medicine options for tobacco-associated NSCLC is a high priority. Umbrella trials seek to streamline the investigation

    更新日期:2020-07-15
  • Antagonistic regulation of the gibberellic acid response during stem growth in rice
    Nature (IF 42.778) Pub Date : 2020-07-15
    Keisuke Nagai; Yoshinao Mori; Shin Ishikawa; Tomoyuki Furuta; Rico Gamuyao; Yoko Niimi; Tokunori Hobo; Moyuri Fukuda; Mikiko Kojima; Yumiko Takebayashi; Atsushi Fukushima; Yasuyo Himuro; Masatomo Kobayashi; Wataru Ackley; Hiroshi Hisano; Kazuhiro Sato; Aya Yoshida; Jianzhong Wu; Hitoshi Sakakibara; Yutaka Sato; Hiroyuki Tsuji; Takashi Akagi; Motoyuki Ashikari

    The size of plants is largely determined by growth of the stem. Stem elongation is stimulated by gibberellic acid1,2,3. Here we show that internode stem elongation in rice is regulated antagonistically by an ‘accelerator’ and a ‘decelerator’ in concert with gibberellic acid. Expression of a gene we name ACCELERATOR OF INTERNODE ELONGATION 1 (ACE1), which encodes a protein of unknown function, confers

    更新日期:2020-07-15
  • A single-cell transcriptomic atlas characterizes ageing tissues in the mouse
    Nature (IF 42.778) Pub Date : 2020-07-15

    Ageing is characterized by a progressive loss of physiological integrity, leading to impaired function and increased vulnerability to death1. Despite rapid advances over recent years, many of the molecular and cellular processes that underlie the progressive loss of healthy physiology are poorly understood2. To gain a better insight into these processes, here we generate a single-cell transcriptomic

    更新日期:2020-07-15
  • Self-assembled poly-catenanes from supramolecular toroidal building blocks
    Nature (IF 42.778) Pub Date : 2020-07-15
    Sougata Datta; Yasuki Kato; Seiya Higashiharaguchi; Keisuke Aratsu; Atsushi Isobe; Takuho Saito; Deepak D. Prabhu; Yuichi Kitamoto; Martin J. Hollamby; Andrew J. Smith; Robert Dagleish; Najet Mahmoudi; Luca Pesce; Claudio Perego; Giovanni M. Pavan; Shiki Yagai

    Mechanical interlocking of molecules (catenation) is a nontrivial challenge in modern synthetic chemistry and materials science1,2. One strategy to achieve catenation is the design of pre-annular molecules that are capable of both efficient cyclization and of pre-organizing another precursor to engage in subsequent interlocking3,4,5,6,7,8,9. This task is particularly difficult when the annular target

    更新日期:2020-07-15
  • Monolithic piezoelectric control of soliton microcombs
    Nature (IF 42.778) Pub Date : 2020-07-15
    Junqiu Liu; Hao Tian; Erwan Lucas; Arslan S. Raja; Grigory Lihachev; Rui Ning Wang; Jijun He; Tianyi Liu; Miles H. Anderson; Wenle Weng; Sunil A. Bhave; Tobias J. Kippenberg

    High-speed actuation of laser frequency1 is critical in applications using lasers and frequency combs2,3, and is a prerequisite for phase locking, frequency stabilization and stability transfer among optical carriers. For example, high-bandwidth feedback control of frequency combs is used in optical-frequency synthesis4, frequency division5 and optical clocks6. Soliton microcombs7,8 have emerged as

    更新日期:2020-07-15
  • Bacterial chemolithoautotrophy via manganese oxidation
    Nature (IF 42.778) Pub Date : 2020-07-15
    Hang Yu; Jared R. Leadbetter

    Manganese is one of the most abundant elements on Earth. The oxidation of manganese has long been theorized1—yet has not been demonstrated2,3,4—to fuel the growth of chemolithoautotrophic microorganisms. Here we refine an enrichment culture that exhibits exponential growth dependent on Mn(II) oxidation to a co-culture of two microbial species. Oxidation required viable bacteria at permissive temperatures

    更新日期:2020-07-15
  • Ageing hallmarks exhibit organ-specific temporal signatures
    Nature (IF 42.778) Pub Date : 2020-07-15
    Nicholas Schaum; Benoit Lehallier; Oliver Hahn; Róbert Pálovics; Shayan Hosseinzadeh; Song E. Lee; Rene Sit; Davis P. Lee; Patricia Morán Losada; Macy E. Zardeneta; Tobias Fehlmann; James T. Webber; Aaron McGeever; Kruti Calcuttawala; Hui Zhang; Daniela Berdnik; Vidhu Mathur; Weilun Tan; Alexander Zee; Michelle Tan; Angela Oliveira Pisco; Jim Karkanias; Norma F. Neff; Andreas Keller; Spyros Darmanis;

    Ageing is the single greatest cause of disease and death worldwide, and understanding the associated processes could vastly improve quality of life. Although major categories of ageing damage have been identified—such as altered intercellular communication, loss of proteostasis and eroded mitochondrial function1—these deleterious processes interact with extraordinary complexity within and between organs

    更新日期:2020-07-15
  • Nucleolar RNA polymerase II drives ribosome biogenesis
    Nature (IF 42.778) Pub Date : 2020-07-15
    Karan J. Abraham; Negin Khosraviani; Janet N. Y. Chan; Aparna Gorthi; Anas Samman; Dorothy Y. Zhao; Miling Wang; Michael Bokros; Elva Vidya; Lauren A. Ostrowski; Roxanne Oshidari; Violena Pietrobon; Parasvi S. Patel; Arash Algouneh; Rajat Singhania; Yupeng Liu; V. Talya Yerlici; Daniel D. De Carvalho; Michael Ohh; Brendan C. Dickson; Razq Hakem; Jack F. Greenblatt; Stephen Lee; Alexander J. R. Bishop;

    Proteins are manufactured by ribosomes—macromolecular complexes of protein and RNA molecules that are assembled within major nuclear compartments called nucleoli1,2. Existing models suggest that RNA polymerases I and III (Pol I and Pol III) are the only enzymes that directly mediate the expression of the ribosomal RNA (rRNA) components of ribosomes. Here we show, however, that RNA polymerase II (Pol

    更新日期:2020-07-15
  • Temperature-dependent growth contributes to long-term cold sensing
    Nature (IF 42.778) Pub Date : 2020-07-15
    Yusheng Zhao; Rea L. Antoniou-Kourounioti; Grant Calder; Caroline Dean; Martin Howard

    Temperature is a key factor in the growth and development of all organisms1,2. Plants have to interpret temperature fluctuations, over hourly to monthly timescales, to align their growth and development with the seasons. Much is known about how plants respond to acute thermal stresses3,4, but the mechanisms that integrate long-term temperature exposure remain unknown. The slow, winter-long upregulation

    更新日期:2020-07-15
  • A universal trade-off between growth and lag in fluctuating environments
    Nature (IF 42.778) Pub Date : 2020-07-15
    Markus Basan; Tomoya Honda; Dimitris Christodoulou; Manuel Hörl; Yu-Fang Chang; Emanuele Leoncini; Avik Mukherjee; Hiroyuki Okano; Brian R. Taylor; Josh M. Silverman; Carlos Sanchez; James R. Williamson; Johan Paulsson; Terence Hwa; Uwe Sauer

    The rate of cell growth is crucial for bacterial fitness and drives the allocation of bacterial resources, affecting, for example, the expression levels of proteins dedicated to metabolism and biosynthesis1,2. It is unclear, however, what ultimately determines growth rates in different environmental conditions. Moreover, increasing evidence suggests that other objectives are also important3,4,5,6,7

    更新日期:2020-07-15
  • Superconductivity in metallic twisted bilayer graphene stabilized by WSe 2
    Nature (IF 42.778) Pub Date : 2020-07-15
    Harpreet Singh Arora; Robert Polski; Yiran Zhang; Alex Thomson; Youngjoon Choi; Hyunjin Kim; Zhong Lin; Ilham Zaky Wilson; Xiaodong Xu; Jiun-Haw Chu; Kenji Watanabe; Takashi Taniguchi; Jason Alicea; Stevan Nadj-Perge

    Magic-angle twisted bilayer graphene (TBG), with rotational misalignment close to 1.1 degrees, features isolated flat electronic bands that host a rich phase diagram of correlated insulating, superconducting, ferromagnetic and topological phases1,2,3,4,5,6. Correlated insulators and superconductivity have been previously observed only for angles within 0.1 degree of the magic angle and occur in adjacent

    更新日期:2020-07-15
  • N 6 -methyladenine in DNA antagonizes SATB1 in early development
    Nature (IF 42.778) Pub Date : 2020-07-15
    Zheng Li; Shuai Zhao; Raman V. Nelakanti; Kaixuan Lin; Tao P. Wu; Myles H. Alderman; Cheng Guo; Pengcheng Wang; Min Zhang; Wang Min; Zongliang Jiang; Yinsheng Wang; Haitao Li; Andrew Z. Xiao

    The recent discovery of N6-methyladenine (N6-mA) in mammalian genomes suggests that it may serve as an epigenetic regulatory mechanism1. However, the biological role of N6-mA and the molecular pathways that exert its function remain unclear. Here we show that N6-mA has a key role in changing the epigenetic landscape during cell fate transitions in early development. We found that N6-mA is upregulated

    更新日期:2020-07-15
  • Vacancy-enabled N 2 activation for ammonia synthesis on an Ni-loaded catalyst
    Nature (IF 42.778) Pub Date : 2020-07-15
    Tian-Nan Ye; Sang-Won Park; Yangfan Lu; Jiang Li; Masato Sasase; Masaaki Kitano; Tomofumi Tada; Hideo Hosono

    Ammonia (NH3) is pivotal to the fertilizer industry and one of the most commonly produced chemicals1. The direct use of atmospheric nitrogen (N2) had been challenging, owing to its large bond energy (945 kilojoules per mole)2,3, until the development of the Haber–Bosch process. Subsequently, many strategies have been explored to reduce the activation barrier of the N≡N bond and make the process more

    更新日期:2020-07-15
  • A subradiant optical mirror formed by a single structured atomic layer
    Nature (IF 42.778) Pub Date : 2020-07-15
    Jun Rui; David Wei; Antonio Rubio-Abadal; Simon Hollerith; Johannes Zeiher; Dan M. Stamper-Kurn; Christian Gross; Immanuel Bloch

    Versatile interfaces with strong and tunable light–matter interactions are essential for quantum science1 because they enable mapping of quantum properties between light and matter1. Recent studies2,3,4,5,6,7,8,9,10 have proposed a method of controlling light–matter interactions using the rich interplay of photon-mediated dipole–dipole interactions in structured subwavelength arrays of quantum emitters

    更新日期:2020-07-15
  • Single-cell lineage tracing unveils a role for TCF15 in haematopoiesis
    Nature (IF 42.778) Pub Date : 2020-07-15
    Alejo E. Rodriguez-Fraticelli; Caleb Weinreb; Shou-Wen Wang; Rosa P. Migueles; Maja Jankovic; Marc Usart; Allon M. Klein; Sally Lowell; Fernando D. Camargo

    Bone marrow transplantation therapy relies on the life-long regenerative capacity of haematopoietic stem cells (HSCs)1,2. HSCs present a complex variety of regenerative behaviours at the clonal level, but the mechanisms underlying this diversity are still undetermined3,4,5,6,7,8,9,10,11. Recent advances in single-cell RNA sequencing have revealed transcriptional differences among HSCs, providing a

    更新日期:2020-07-15
  • Compression of curium pyrrolidine-dithiocarbamate enhances covalency
    Nature (IF 42.778) Pub Date : 2020-07-15
    Joseph M. Sperling; Evan J. Warzecha; Cristian Celis-Barros; Dumitru-Claudiu Sergentu; Xiaoyu Wang; Bonnie E. Klamm; Cory J. Windorff; Alyssa N. Gaiser; Frankie D. White; Drake A. Beery; Alexander T. Chemey; Megan A. Whitefoot; Brian N. Long; Kenneth Hanson; Paul Kögerler; Manfred Speldrich; Eva Zurek; Jochen Autschbach; Thomas E. Albrecht-Schönzart

    Curium is unique in the actinide series because its half-filled 5f 7 shell has lower energy than other 5f n configurations, rendering it both redox-inactive and resistant to forming chemical bonds that engage the 5f shell1,2,3. This is even more pronounced in gadolinium, curium’s lanthanide analogue, owing to the contraction of the 4f orbitals with respect to the 5f orbitals4. However, at high pressures

    更新日期:2020-07-15
  • Antarctica’s wilderness fails to capture continent’s biodiversity
    Nature (IF 42.778) Pub Date : 2020-07-15
    Rachel I. Leihy; Bernard W. T. Coetzee; Fraser Morgan; Ben Raymond; Justine D. Shaw; Aleks Terauds; Kees Bastmeijer; Steven L. Chown

    Recent assessments of Earth’s dwindling wilderness have emphasized that Antarctica is a crucial wilderness in need of protection1,2. Yet human impacts on the continent are widespread3,4,5, the extent of its wilderness unquantified2 and the importance thereof for biodiversity conservation unknown. Here we assemble a comprehensive record of human activity (approximately 2.7 million records, spanning

    更新日期:2020-07-15
  • Telomere-to-telomere assembly of a complete human X chromosome
    Nature (IF 42.778) Pub Date : 2020-07-14
    Karen H. Miga; Sergey Koren; Arang Rhie; Mitchell R. Vollger; Ariel Gershman; Andrey Bzikadze; Shelise Brooks; Edmund Howe; David Porubsky; Glennis A. Logsdon; Valerie A. Schneider; Tamara Potapova; Jonathan Wood; William Chow; Joel Armstrong; Jeanne Fredrickson; Evgenia Pak; Kristof Tigyi; Milinn Kremitzki; Christopher Markovic; Valerie Maduro; Amalia Dutra; Gerard G. Bouffard; Alexander M. Chang;

    After two decades of improvements, the current human reference genome (GRCh38) is the most accurate and complete vertebrate genome ever produced. However, no one chromosome has been finished end to end, and hundreds of unresolved gaps persist1,2. Here we present a de novo human genome assembly that surpasses the continuity of GRCh382, along with the first gapless, telomere-to-telomere assembly of a

    更新日期:2020-07-14
  • A perspective on potential antibody-dependent enhancement of SARS-CoV-2
    Nature (IF 42.778) Pub Date : 2020-07-13
    Ann M. Arvin; Katja Fink; Michael A. Schmid; Andrea Cathcart; Roberto Spreafico; Colin Havenar-Daughton; Antonio Lanzavecchia; Davide Corti; Herbert W. Virgin

    The possibility of antibody-dependent enhancement (ADE) of disease is a general concern for the development of vaccines and antibody therapies because the mechanisms that underlie antibody protection have the theoretical potential to amplify viral infections or trigger immunopathology. Observations relevant to the risks of ADE of disease require careful review at this critical point in the SARS-CoV-2

    更新日期:2020-07-13
  • Structural basis for RIFIN-mediated activation of LILRB1 in malaria
    Nature (IF 42.778) Pub Date : 2020-07-10
    Thomas E. Harrison; Alexander M. Mørch; James H. Felce; Akihito Sakoguchi; Adam J. Reid; Hisashi Arase; Michael L. Dustin; Matthew K. Higgins

    The Plasmodium species that cause malaria are obligate intracellular parasites, and disease symptoms occur as they replicate within human blood. Despite risking immune detection, the parasite delivers proteins that bind host receptors to infected erythrocyte surfaces. In the causative agent of the most deadly human malaria, Plasmodium falciparum, RIFINs form the largest erythrocyte surface protein

    更新日期:2020-07-10
  • Structures of fungal and plant acetohydroxyacid synthases
    Nature (IF 42.778) Pub Date : 2020-07-08
    Thierry Lonhienne; Yu Shang Low; Mario D. Garcia; Tristan Croll; Yan Gao; Quan Wang; Lou Brillault; Craig M. Williams; James A. Fraser; Ross P. McGeary; Nicholas P. West; Michael J. Landsberg; Zihe Rao; Gerhard Schenk; Luke W. Guddat

    Acetohydroxyacid synthase (AHAS), also known as acetolactate synthase, is a FAD and ThDP-Mg2+-dependent enzyme that catalyses the first step in the biosynthesis of the branched chain amino acids (BCAAs)1. It is the target for over 50 commercial herbicides2. AHAS requires both catalytic and regulatory subunits for maximal activity and functionality. Herein, our structures of the hexadecameric Saccharomyces

    更新日期:2020-07-08
  • OpenSAFELY: factors associated with COVID-19 death in 17 million patients
    Nature (IF 42.778) Pub Date : 2020-07-08
    Elizabeth J. Williamson; Alex J. Walker; Krishnan Bhaskaran; Seb Bacon; Chris Bates; Caroline E. Morton; Helen J. Curtis; Amir Mehrkar; David Evans; Peter Inglesby; Jonathan Cockburn; Helen I. McDonald; Brian MacKenna; Laurie Tomlinson; Ian J. Douglas; Christopher T. Rentsch; Rohini Mathur; Angel Y. S. Wong; Richard Grieve; David Harrison; Harriet Forbes; Anna Schultze; Richard Croker; John Parry;

    COVID-19 has rapidly affected mortality worldwide1. There is unprecedented urgency to understand who is most at risk of severe outcomes, requiring new approaches for timely analysis of large datasets. Working on behalf of NHS England, here we created OpenSAFELY: a secure health analytics platform covering 40% of all patients in England, holding patient data within the existing data centre of a major

    更新日期:2020-07-08
  • Massive haplotypes underlie ecotypic differentiation in sunflowers
    Nature (IF 42.778) Pub Date : 2020-07-08
    Marco Todesco; Gregory L. Owens; Natalia Bercovich; Jean-Sébastien Légaré; Shaghayegh Soudi; Dylan O. Burge; Kaichi Huang; Katherine L. Ostevik; Emily B. M. Drummond; Ivana Imerovski; Kathryn Lande; Mariana A. Pascual-Robles; Mihir Nanavati; Mojtaba Jahani; Winnie Cheung; S. Evan Staton; Stéphane Muños; Rasmus Nielsen; Lisa A. Donovan; John M. Burke; Sam Yeaman; Loren H. Rieseberg

    Species often include multiple ecotypes that are adapted to different environments1. However, it is unclear how ecotypes arise and how their distinctive combinations of adaptive alleles are maintained despite hybridization with non-adapted populations2,3,4. Here, by resequencing 1,506 wild sunflowers from 3 species (Helianthus annuus, Helianthus petiolaris and Helianthus argophyllus), we identify 37 large

    更新日期:2020-07-08
  • Extracellular proteostasis prevents aggregation during pathogenic attack
    Nature (IF 42.778) Pub Date : 2020-07-08
    Ivan Gallotta; Aneet Sandhu; Maximilian Peters; Martin Haslbeck; Raimund Jung; Sinem Agilkaya; Jane L. Blersch; Christian Rödelsperger; Waltraud Röseler; Chaolie Huang; Ralf J. Sommer; Della C. David

    In metazoans, the secreted proteome participates in intercellular signalling and innate immunity, and builds the extracellular matrix scaffold around cells. Compared with the relatively constant intracellular environment, conditions for proteins in the extracellular space are harsher, and low concentrations of ATP prevent the activity of intracellular components of the protein quality-control machinery

    更新日期:2020-07-08
  • Tunable spin-polarized correlated states in twisted double bilayer graphene
    Nature (IF 42.778) Pub Date : 2020-07-08
    Xiaomeng Liu; Zeyu Hao; Eslam Khalaf; Jong Yeon Lee; Yuval Ronen; Hyobin Yoo; Danial Haei Najafabadi; Kenji Watanabe; Takashi Taniguchi; Ashvin Vishwanath; Philip Kim

    Reducing the energy bandwidth of electrons in a lattice below the long-range Coulomb interaction energy promotes correlation effects. Moiré superlattices—which are created by stacking van der Waals heterostructures with a controlled twist angle1,2,3—enable the engineering of electron band structure. Exotic quantum phases can emerge in an engineered moiré flat band. The recent discovery of correlated

    更新日期:2020-07-08
  • Coherent control of a surface structural phase transition
    Nature (IF 42.778) Pub Date : 2020-07-08
    Jan Gerrit Horstmann; Hannes Böckmann; Bareld Wit; Felix Kurtz; Gero Storeck; Claus Ropers

    Active optical control over matter is desirable in many scientific disciplines, with prominent examples in all-optical magnetic switching1,2, light-induced metastable or exotic phases of solids3,4,5,6,7,8 and the coherent control of chemical reactions9,10. Typically, these approaches dynamically steer a system towards states or reaction products far from equilibrium. In solids, metal-to-insulator transitions

    更新日期:2020-07-08
  • A bacterial cytidine deaminase toxin enables CRISPR-free mitochondrial base editing
    Nature (IF 42.778) Pub Date : 2020-07-08
    Beverly Y. Mok; Marcos H. de Moraes; Jun Zeng; Dustin E. Bosch; Anna V. Kotrys; Aditya Raguram; FoSheng Hsu; Matthew C. Radey; S. Brook Peterson; Vamsi K. Mootha; Joseph D. Mougous; David R. Liu

    Bacterial toxins represent a vast reservoir of biochemical diversity that can be repurposed for biomedical applications. Such proteins include a group of predicted interbacterial toxins of the deaminase superfamily, members of which have found application in gene-editing techniques1,2. Because previously described cytidine deaminases operate on single-stranded nucleic acids3, their use in base editing

    更新日期:2020-07-08
  • Sodium regulates clock time and output via an excitatory GABAergic pathway
    Nature (IF 42.778) Pub Date : 2020-07-08
    Claire Gizowski; Charles W. Bourque

    The suprachiasmatic nucleus (SCN) serves as the body’s master circadian clock that adaptively coordinates changes in physiology and behaviour in anticipation of changing requirements throughout the 24-h day–night cycle1,2,3,4. For example, the SCN opposes overnight adipsia by driving water intake before sleep5,6, and by driving the secretion of anti-diuretic hormone7,8 and lowering body temperature9

    更新日期:2020-07-08
  • Native American gene flow into Polynesia predating Easter Island settlement
    Nature (IF 42.778) Pub Date : 2020-07-08
    Alexander G. Ioannidis; Javier Blanco-Portillo; Karla Sandoval; Erika Hagelberg; Juan Francisco Miquel-Poblete; J. Víctor Moreno-Mayar; Juan Esteban Rodríguez-Rodríguez; Consuelo D. Quinto-Cortés; Kathryn Auckland; Tom Parks; Kathryn Robson; Adrian V. S. Hill; María C. Avila-Arcos; Alexandra Sockell; Julian R. Homburger; Genevieve L. Wojcik; Kathleen C. Barnes; Luisa Herrera; Soledad Berríos; Mónica

    The possibility of voyaging contact between prehistoric Polynesian and Native American populations has long intrigued researchers. Proponents have pointed to the existence of New World crops, such as the sweet potato and bottle gourd, in the Polynesian archaeological record, but nowhere else outside the pre-Columbian Americas1,2,3,4,5,6, while critics have argued that these botanical dispersals need

    更新日期:2020-07-08
  • Mitochondrial ubiquinol oxidation is necessary for tumour growth
    Nature (IF 42.778) Pub Date : 2020-07-08
    Inmaculada Martínez-Reyes; Luzivette Robles Cardona; Hyewon Kong; Karthik Vasan; Gregory S. McElroy; Marie Werner; Hermon Kihshen; Colleen R. Reczek; Samuel E. Weinberg; Peng Gao; Elizabeth M. Steinert; Raul Piseaux; G. R. Scott Budinger; Navdeep S. Chandel

    The mitochondrial electron transport chain (ETC) is necessary for tumour growth1,2,3,4,5,6 and its inhibition has demonstrated anti-tumour efficacy in combination with targeted therapies7,8,9. Furthermore, human brain and lung tumours display robust glucose oxidation by mitochondria10,11. However, it is unclear why a functional ETC is necessary for tumour growth in vivo. ETC function is coupled to

    更新日期:2020-07-08
  • Fitness trade-offs incurred by ovary-to-gut steroid signalling in Drosophila
    Nature (IF 42.778) Pub Date : 2020-07-08
    Sara Mahmoud H. Ahmed; Julieta A. Maldera; Damir Krunic; Gabriela O. Paiva-Silva; Clothilde Pénalva; Aurelio A. Teleman; Bruce A. Edgar

    Sexual dimorphism arises from genetic differences between male and female cells, and from systemic hormonal differences1,2,3. How sex hormones affect non-reproductive organs is poorly understood, yet highly relevant to health given the sex-biased incidence of many diseases4. Here we report that steroid signalling in Drosophila from the ovaries to the gut promotes growth of the intestine specifically

    更新日期:2020-07-08
  • Asymmetric mass ratios for bright double neutron-star mergers
    Nature (IF 42.778) Pub Date : 2020-07-08
    R. D. Ferdman; P. C. C. Freire; B. B. P. Perera; N. Pol; F. Camilo; S. Chatterjee; J. M. Cordes; F. Crawford; J. W. T. Hessels; V. M. Kaspi; M. A. McLaughlin; E. Parent; I. H. Stairs; J. van Leeuwen

    The discovery of a radioactively powered kilonova associated with the binary neutron-star merger GW170817 remains the only confirmed electromagnetic counterpart to a gravitational-wave event1,2. Observations of the late-time electromagnetic emission, however, do not agree with the expectations from standard neutron-star merger models. Although the large measured ejecta mass3,4 could be explained by

    更新日期:2020-07-08
  • Large-scale integration of artificial atoms in hybrid photonic circuits
    Nature (IF 42.778) Pub Date : 2020-07-08
    Noel H. Wan; Tsung-Ju Lu; Kevin C. Chen; Michael P. Walsh; Matthew E. Trusheim; Lorenzo De Santis; Eric A. Bersin; Isaac B. Harris; Sara L. Mouradian; Ian R. Christen; Edward S. Bielejec; Dirk Englund

    A central challenge in developing quantum computers and long-range quantum networks is the distribution of entanglement across many individually controllable qubits1. Colour centres in diamond have emerged as leading solid-state ‘artificial atom’ qubits2,3 because they enable on-demand remote entanglement4, coherent control of over ten ancillae qubits with minute-long coherence times5 and memory-enhanced

    更新日期:2020-07-08
  • Irritant-evoked activation and calcium modulation of the TRPA1 receptor
    Nature (IF 42.778) Pub Date : 2020-07-08
    Jianhua Zhao; John V. Lin King; Candice E. Paulsen; Yifan Cheng; David Julius

    The transient receptor potential ion channel TRPA1 is expressed by primary afferent nerve fibres, in which it functions as a low-threshold sensor for structurally diverse electrophilic irritants, including small volatile environmental toxicants and endogenous algogenic lipids1. TRPA1 is also a ‘receptor-operated’ channel whose activation downstream of metabotropic receptors elicits inflammatory pain

    更新日期:2020-07-08
  • Envelope protein ubiquitination drives entry and pathogenesis of Zika virus
    Nature (IF 42.778) Pub Date : 2020-07-08
    Maria I. Giraldo; Hongjie Xia; Leopoldo Aguilera-Aguirre; Adam Hage; Sarah van Tol; Chao Shan; Xuping Xie; Gail L. Sturdevant; Shelly J. Robertson; Kristin L. McNally; Kimberly Meade-White; Sasha R. Azar; Shannan L. Rossi; Wendy Maury; Michael Woodson; Holly Ramage; Jeffrey R. Johnson; Nevan J. Krogan; Marc C. Morais; Sonja M. Best; Pei-Yong Shi; Ricardo Rajsbaum

    Zika virus (ZIKV) belongs to the family Flaviviridae, and is related to other viruses that cause human diseases. Unlike other flaviviruses, ZIKV infection can cause congenital neurological disorders and replicates efficiently in reproductive tissues1,2,3. Here we show that the envelope protein (E) of ZIKV is polyubiquitinated by the E3 ubiquitin ligase TRIM7 through Lys63 (K63)-linked polyubiquitination

    更新日期:2020-07-08
  • A mobile robotic chemist
    Nature (IF 42.778) Pub Date : 2020-07-08
    Benjamin Burger; Phillip M. Maffettone; Vladimir V. Gusev; Catherine M. Aitchison; Yang Bai; Xiaoyan Wang; Xiaobo Li; Ben M. Alston; Buyi Li; Rob Clowes; Nicola Rankin; Brandon Harris; Reiner Sebastian Sprick; Andrew I. Cooper

    Technologies such as batteries, biomaterials and heterogeneous catalysts have functions that are defined by mixtures of molecular and mesoscale components. As yet, this multi-length-scale complexity cannot be fully captured by atomistic simulations, and the design of such materials from first principles is still rare1,2,3,4,5. Likewise, experimental complexity scales exponentially with the number of

    更新日期:2020-07-08
  • Glucose metabolism links astroglial mitochondria to cannabinoid effects
    Nature (IF 42.778) Pub Date : 2020-07-08
    Daniel Jimenez-Blasco; Arnau Busquets-Garcia; Etienne Hebert-Chatelain; Roman Serrat; Carlos Vicente-Gutierrez; Christina Ioannidou; Paula Gómez-Sotres; Irene Lopez-Fabuel; Monica Resch-Beusher; Eva Resel; Dorian Arnouil; Dave Saraswat; Marjorie Varilh; Astrid Cannich; Francisca Julio-Kalajzic; Itziar Bonilla-Del Río; Angeles Almeida; Nagore Puente; Svein Achicallende; Maria-Luz Lopez-Rodriguez; Charlotte

    Astrocytes take up glucose from the bloodstream to provide energy to the brain, thereby allowing neuronal activity and behavioural responses1,2,3,4,5. By contrast, astrocytes are under neuronal control through specific neurotransmitter receptors5,6,7. However, whether the activation of astroglial receptors can directly regulate cellular glucose metabolism to eventually modulate behavioural responses

    更新日期:2020-07-08
  • Potential for large-scale CO 2 removal via enhanced rock weathering with croplands
    Nature (IF 42.778) Pub Date : 2020-07-08
    David J. Beerling; Euripides P. Kantzas; Mark R. Lomas; Peter Wade; Rafael M. Eufrasio; Phil Renforth; Binoy Sarkar; M. Grace Andrews; Rachael H. James; Christopher R. Pearce; Jean-Francois Mercure; Hector Pollitt; Philip B. Holden; Neil R. Edwards; Madhu Khanna; Lenny Koh; Shaun Quegan; Nick F. Pidgeon; Ivan A. Janssens; James Hansen; Steven A. Banwart

    Enhanced silicate rock weathering (ERW), deployable with croplands, has potential use for atmospheric carbon dioxide (CO2) removal (CDR), which is now necessary to mitigate anthropogenic climate change1. ERW also has possible co-benefits for improved food and soil security, and reduced ocean acidification2,3,4. Here we use an integrated performance modelling approach to make an initial techno-economic

    更新日期:2020-07-08
  • Microbiota modulate sympathetic neurons via a gut–brain circuit
    Nature (IF 42.778) Pub Date : 2020-07-08
    Paul A. Muller; Marc Schneeberger; Fanny Matheis; Putianqi Wang; Zachary Kerner; Anoj Ilanges; Kyle Pellegrino; Josefina del Mármol; Tiago B. R. Castro; Munehiro Furuichi; Matthew Perkins; Wenfei Han; Arka Rao; Amanda J. Picard; Justin R. Cross; Kenya Honda; Ivan de Araujo; Daniel Mucida

    Connections between the gut and brain monitor the intestinal tissue and its microbial and dietary content1, regulating both physiological intestinal functions such as nutrient absorption and motility2,3, and brain-wired feeding behaviour2. It is therefore plausible that circuits exist to detect gut microorganisms and relay this information to areas of the central nervous system that, in turn, regulate

    更新日期:2020-07-08
  • Untying the insulating and superconducting orders in magic-angle graphene
    Nature (IF 42.778) Pub Date : 2020-07-06
    Petr Stepanov; Ipsita Das; Xiaobo Lu; Ali Fahimniya; Kenji Watanabe; Takashi Taniguchi; Frank H. L. Koppens; Johannes Lischner; Leonid Levitov; Dmitri K. Efetov

    The coexistence of superconducting and correlated insulating states in magic-angle twisted bilayer graphene1,2,3,4,5,6,7,8,9,10,11 prompts fascinating questions about their relationship. Independent control of the microscopic mechanisms that govern these phases could help uncover their individual roles and shed light on their intricate interplay. Here we report on direct tuning of electronic interactions

    更新日期:2020-07-06
  • Structural basis of CXC chemokine receptor 2 activation and signalling
    Nature (IF 42.778) Pub Date : 2020-07-01
    Kaiwen Liu; Lijie Wu; Shuguang Yuan; Meng Wu; Yueming Xu; Qianqian Sun; Shu Li; Suwen Zhao; Tian Hua; Zhi-Jie Liu

    Chemokines and their receptors mediate cell migration, which influences multiple fundamental biological processes and disease conditions, such as inflammation and cancer1. Although ample efforts have been invested into the structural investigation of the chemokine receptors and receptor–chemokine recognition2–4, less is known about endogenous chemokine-induced receptor activation and G protein coupling

    更新日期:2020-07-01
  • Observation of branched flow of light
    Nature (IF 42.778) Pub Date : 2020-07-01
    Anatoly Patsyk; Uri Sivan; Mordechai Segev; Miguel A. Bandres

    When waves propagate through a weak disordered potential with correlation length larger than the wavelength, they form channels (branches) of enhanced intensity that keep dividing as the waves propagate1. This fundamental wave phenomenon is known as branched flow. It was first observed for electrons1,2,3,4,5,6 and for microwave cavities7,8, and it is generally expected for waves with vastly different

    更新日期:2020-07-01
  • Suppression of proteolipid protein rescues Pelizaeus-Merzbacher disease
    Nature (IF 42.778) Pub Date : 2020-07-01
    Matthew S. Elitt; Lilianne Barbar; H. Elizabeth Shick; Berit E. Powers; Yuka Maeno-Hikichi; Mayur Madhavan; Kevin C. Allan; Baraa S. Nawash; Artur S. Gevorgyan; Stevephen Hung; Zachary S. Nevin; Hannah E. Olsen; Midori Hitomi; Daniela M. Schlatzer; Hien T. Zhao; Adam Swayze; David F. LePage; Weihong Jiang; Ronald A. Conlon; Frank Rigo; Paul J. Tesar

    Mutations in proteolipid protein 1 (PLP1) result in failure of myelination and neurological dysfunction in the X-linked leukodystrophy Pelizaeus-Merzbacher disease (PMD)1,2. Most PLP1 mutations, including point mutations and supernumerary copy variants, lead to severe and fatal disease. PLP1-null patients and mice, however, can display comparatively mild phenotypes, suggesting that PLP1-suppression

    更新日期:2020-07-01
  • Chemical gradients in human enamel crystallites
    Nature (IF 42.778) Pub Date : 2020-07-01
    Karen A. DeRocher; Paul J. M. Smeets; Berit H. Goodge; Michael J. Zachman; Prasanna V. Balachandran; Linus Stegbauer; Michael J. Cohen; Lyle M. Gordon; James M. Rondinelli; Lena F. Kourkoutis; Derk Joester

    Dental enamel is a principal component of teeth1, and has evolved to bear large chewing forces, resist mechanical fatigue and withstand wear over decades2. Functional impairment and loss of dental enamel, caused by developmental defects or tooth decay (caries), affect health and quality of life, with associated costs to society3. Although the past decade has seen progress in our understanding of enamel

    更新日期:2020-07-01
  • Abrupt increase in harvested forest area over Europe after 2015
    Nature (IF 42.778) Pub Date : 2020-07-01
    Guido Ceccherini; Gregory Duveiller; Giacomo Grassi; Guido Lemoine; Valerio Avitabile; Roberto Pilli; Alessandro Cescatti

    Forests provide a series of ecosystem services that are crucial to our society. In the European Union (EU), forests account for approximately 38% of the total land surface1. These forests are important carbon sinks, and their conservation efforts are vital for the EU’s vision of achieving climate neutrality by 20502. However, the increasing demand for forest services and products, driven by the bioeconomy

    更新日期:2020-07-01
  • A remnant planetary core in the hot-Neptune desert
    Nature (IF 42.778) Pub Date : 2020-07-01
    David J. Armstrong; Théo A. Lopez; Vardan Adibekyan; Richard A. Booth; Edward M. Bryant; Karen A. Collins; Magali Deleuil; Alexandre Emsenhuber; Chelsea X. Huang; George W. King; Jorge Lillo-Box; Jack J. Lissauer; Elisabeth Matthews; Olivier Mousis; Louise D. Nielsen; Hugh Osborn; Jon Otegi; Nuno C. Santos; Sérgio G. Sousa; Keivan G. Stassun; Dimitri Veras; Carl Ziegler; Jack S. Acton; Jose M. Almenara;

    The interiors of giant planets remain poorly understood. Even for the planets in the Solar System, difficulties in observation lead to large uncertainties in the properties of planetary cores. Exoplanets that have undergone rare evolutionary processes provide a route to understanding planetary interiors. Planets found in and near the typically barren hot-Neptune ‘desert’1,2 (a region in mass–radius

    更新日期:2020-07-01
  • Structural cells are key regulators of organ-specific immune responses
    Nature (IF 42.778) Pub Date : 2020-07-01
    Thomas Krausgruber; Nikolaus Fortelny; Victoria Fife-Gernedl; Martin Senekowitsch; Linda C. Schuster; Alexander Lercher; Amelie Nemc; Christian Schmidl; André F. Rendeiro; Andreas Bergthaler; Christoph Bock

    The mammalian immune system implements a remarkably effective set of mechanisms for fighting pathogens1. Its main components are haematopoietic immune cells, including myeloid cells that control innate immunity, and lymphoid cells that constitute adaptive immunity2. However, immune functions are not unique to haematopoietic cells, and many other cell types display basic mechanisms of pathogen defence3

    更新日期:2020-07-01
  • Clinical targeting of HIV capsid protein with a long-acting small molecule
    Nature (IF 42.778) Pub Date : 2020-07-01
    John O. Link; Martin S. Rhee; Winston C. Tse; Jim Zheng; John R. Somoza; William Rowe; Rebecca Begley; Anna Chiu; Andrew Mulato; Derek Hansen; Eric Singer; Luong K. Tsai; Rujuta A. Bam; Chien-Hung Chou; Eda Canales; Gediminas Brizgys; Jennifer R. Zhang; Jiayao Li; Michael Graupe; Philip Morganelli; Qi Liu; Qiaoyin Wu; Randall L. Halcomb; Roland D. Saito; Scott D. Schroeder; Scott E. Lazerwith; Steven

    Oral antiretroviral agents provide life-saving treatments for millions of people living with HIV, and can prevent new infections via pre-exposure prophylaxis1,2,3,4,5. However, some people living with HIV who are heavily treatment-experienced have limited or no treatment options, owing to multidrug resistance6. In addition, suboptimal adherence to oral daily regimens can negatively affect the outcome

    更新日期:2020-07-01
  • Laser picoscopy of valence electrons in solids
    Nature (IF 42.778) Pub Date : 2020-07-01
    H. Lakhotia; H. Y. Kim; M. Zhan; S. Hu; S. Meng; E. Goulielmakis

    Valence electrons contribute a small fraction of the total electron density of materials, but they determine their essential chemical, electronic and optical properties. Strong laser fields can probe electrons in valence orbitals1,2,3 and their dynamics4,5,6 in the gas phase. Previous laser studies of solids have associated high-harmonic emission7,8,9,10,11,12 with the spatial arrangement of atoms

    更新日期:2020-07-01
  • Extensive signal integration by the phytohormone protein network
    Nature (IF 42.778) Pub Date : 2020-07-01
    Melina Altmann; Stefan Altmann; Patricia A. Rodriguez; Benjamin Weller; Lena Elorduy Vergara; Julius Palme; Nora Marín-de la Rosa; Mayra Sauer; Marion Wenig; José Antonio Villaécija-Aguilar; Jennifer Sales; Chung-Wen Lin; Ramakrishnan Pandiarajan; Veronika Young; Alexandra Strobel; Lisa Gross; Samy Carbonnel; Karl G. Kugler; Antoni Garcia-Molina; George W. Bassel; Claudia Falter; Klaus F. X. Mayer;

    Plant hormones coordinate responses to environmental cues with developmental programs1, and are fundamental for stress resilience and agronomic yield2. The core signalling pathways underlying the effects of phytohormones have been elucidated by genetic screens and hypothesis-driven approaches, and extended by interactome studies of select pathways3. However, fundamental questions remain about how information

    更新日期:2020-07-01
  • Systematic quantitative analysis of ribosome inventory during nutrient stress
    Nature (IF 42.778) Pub Date : 2020-07-01
    Heeseon An; Alban Ordureau; Maria Körner; Joao A. Paulo; J. Wade Harper

    Mammalian cells reorganize their proteomes in response to nutrient stress through translational suppression and degradative mechanisms using the proteasome and autophagy systems1,2. Ribosomes are central targets of this response, as they are responsible for translation and subject to lysosomal turnover during nutrient stress3,4,5. The abundance of ribosomal (r)-proteins (around 6% of the proteome;

    更新日期:2020-07-01
  • Physiological blood–brain transport is impaired with age by a shift in transcytosis
    Nature (IF 42.778) Pub Date : 2020-07-01
    Andrew C. Yang; Marc Y. Stevens; Michelle B. Chen; Davis P. Lee; Daniel Stähli; David Gate; Kévin Contrepois; Winnie Chen; Tal Iram; Lichao Zhang; Ryan T. Vest; Aisling Chaney; Benoit Lehallier; Niclas Olsson; Haley du Bois; Ryan Hsieh; Haley C. Cropper; Daniela Berdnik; Lulin Li; Elizabeth Y. Wang; Gavin M. Traber; Carolyn R. Bertozzi; Jian Luo; Michael P. Snyder; Joshua E. Elias; Stephen R. Quake;

    The vascular interface of the brain, known as the blood–brain barrier (BBB), is understood to maintain brain function in part via its low transcellular permeability1,2,3. Yet, recent studies have demonstrated that brain ageing is sensitive to circulatory proteins4,5. Thus, it is unclear whether permeability to individually injected exogenous tracers—as is standard in BBB studies—fully represents blood-to-brain

    更新日期:2020-07-01
  • A substrate-specific mTORC1 pathway underlies Birt–Hogg–Dubé syndrome
    Nature (IF 42.778) Pub Date : 2020-07-01
    Gennaro Napolitano; Chiara Di Malta; Alessandra Esposito; Mariana E. G. de Araujo; Salvatore Pece; Giovanni Bertalot; Maria Matarese; Valerio Benedetti; Angela Zampelli; Taras Stasyk; Diletta Siciliano; Alessandro Venuta; Marcella Cesana; Claudia Vilardo; Edoardo Nusco; Jlenia Monfregola; Alessia Calcagnì; Pier Paolo Di Fiore; Lukas A. Huber; Andrea Ballabio

    The mechanistic target of rapamycin complex 1 (mTORC1) is a key metabolic hub that controls the cellular response to environmental cues by exerting its kinase activity on multiple substrates1,2,3. However, whether mTORC1 responds to diverse stimuli by differentially phosphorylating specific substrates is poorly understood. Here we show that transcription factor EB (TFEB), a master regulator of lysosomal

    更新日期:2020-07-01
  • Structure and flexibility in cortical representations of odour space
    Nature (IF 42.778) Pub Date : 2020-07-01
    Stan L. Pashkovski; Giuliano Iurilli; David Brann; Daniel Chicharro; Kristen Drummey; Kevin Franks; Stefano Panzeri; Sandeep Robert Datta

    The cortex organizes sensory information to enable discrimination and generalization1,2,3,4. As systematic representations of chemical odour space have not yet been described in the olfactory cortex, it remains unclear how odour relationships are encoded to place chemically distinct but similar odours, such as lemon and orange, into perceptual categories, such as citrus5,6,7. Here, by combining chemoinformatics

    更新日期:2020-07-01
  • Quantum correlations between light and the kilogram-mass mirrors of LIGO
    Nature (IF 42.778) Pub Date : 2020-07-01
    Haocun Yu; L. McCuller; M. Tse; N. Kijbunchoo; L. Barsotti; N. Mavalvala

    The measurement of minuscule forces and displacements with ever greater precision is inhibited by the Heisenberg uncertainty principle, which imposes a limit to the precision with which the position of an object can be measured continuously, known as the standard quantum limit1,2,3,4. When light is used as the probe, the standard quantum limit arises from the balance between the uncertainties of the

    更新日期:2020-07-01
  • Cryo-EM of elongating ribosome with EF-Tu•GTP elucidates tRNA proofreading
    Nature (IF 42.778) Pub Date : 2020-07-01
    Anna B. Loveland; Gabriel Demo; Andrei A. Korostelev

    Ribosomes accurately decode mRNA by proofreading each aminoacyl-tRNA that is delivered by the elongation factor EF-Tu1. To understand the molecular mechanism of this proofreading step it is necessary to visualize GTP-catalysed elongation, which has remained a challenge2,3,4. Here we use time-resolved cryogenic electron microscopy to reveal 33 ribosomal states after the delivery of aminoacyl-tRNA by

    更新日期:2020-07-01
  • Wapl repression by Pax5 promotes V gene recombination by Igh loop extrusion
    Nature (IF 42.778) Pub Date : 2020-07-01
    Louisa Hill; Anja Ebert; Markus Jaritz; Gordana Wutz; Kota Nagasaka; Hiromi Tagoh; Daniela Kostanova-Poliakova; Karina Schindler; Qiong Sun; Peter Bönelt; Maria Fischer; Jan-Michael Peters; Meinrad Busslinger

    Nuclear processes, such as V(D)J recombination, are orchestrated by the three-dimensional organization of chromosomes at multiple levels, including compartments1 and topologically associated domains (TADs)2,3 consisting of chromatin loops4. TADs are formed by chromatin-loop extrusion5,6,7, which depends on the loop-extrusion function of the ring-shaped cohesin complex8,9,10,11,12. Conversely, the cohesin-release

    更新日期:2020-07-01
Contents have been reproduced by permission of the publishers.
导出
全部期刊列表>>
产业、创新与基础设施
AI核心技术
10years
自然科研线上培训服务
材料学研究精选
Springer Nature Live 产业与创新线上学术论坛
胸腔和胸部成像专题
自然科研论文编辑服务
ACS ES&T Engineering
ACS ES&T Water
屿渡论文,编辑服务
杨超勇
周一歌
华东师范大学
段炼
清华大学
廖矿标
李远
跟Nature、Science文章学绘图
隐藏1h前已浏览文章
中洪博元
课题组网站
新版X-MOL期刊搜索和高级搜索功能介绍
ACS材料视界
x-mol收录
福州大学
南京大学
王杰
丘龙斌
电子显微学
何凤
洛杉矶分校
吴杰
赵延川
试剂库存
天合科研
down
wechat
bug