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Cellular development and evolution of the mammalian cerebellum Nature (IF 64.8) Pub Date : 2023-11-29 Mari Sepp, Kevin Leiss, Florent Murat, Konstantin Okonechnikov, Piyush Joshi, Evgeny Leushkin, Lisa Spänig, Noe Mbengue, Céline Schneider, Julia Schmidt, Nils Trost, Maria Schauer, Philipp Khaitovich, Steven Lisgo, Miklós Palkovits, Peter Giere, Lena M. Kutscher, Simon Anders, Margarida Cardoso-Moreira, Ioannis Sarropoulos, Stefan M. Pfister, Henrik Kaessmann
The expansion of the neocortex, a hallmark of mammalian evolution1,2, was accompanied by an increase in cerebellar neuron numbers3. However, little is known about the evolution of the cellular programs underlying cerebellum development in mammals. In this study, we generated single-nucleus RNA-sequencing data for ~400,000 cells to trace cerebellum development from early neurogenesis to adulthood in
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A stable atmospheric-pressure plasma for extreme-temperature synthesis Nature (IF 64.8) Pub Date : 2023-11-29 Hua Xie, Ning Liu, Qian Zhang, Hongtao Zhong, Liqun Guo, Xinpeng Zhao, Daozheng Li, Shufeng Liu, Zhennan Huang, Aditya Dilip Lele, Alexandra H. Brozena, Xizheng Wang, Keqi Song, Sophia Chen, Yan Yao, Miaofang Chi, Wei Xiong, Jiancun Rao, Minhua Zhao, Mikhail N. Shneider, Jian Luo, Ji-Cheng Zhao, Yiguang Ju, Liangbing Hu
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MSL2 ensures biallelic gene expression in mammals Nature (IF 64.8) Pub Date : 2023-11-29 Yidan Sun, Meike Wiese, Raed Hmadi, Remzi Karayol, Janine Seyfferth, Juan Alfonso Martinez Greene, Niyazi Umut Erdogdu, Ward Deboutte, Laura Arrigoni, Herbert Holz, Gina Renschler, Naama Hirsch, Arion Foertsch, Maria Felicia Basilicata, Thomas Stehle, Maria Shvedunova, Chiara Bella, Cecilia Pessoa Rodrigues, Bjoern Schwalb, Patrick Cramer, Thomas Manke, Asifa Akhtar
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An autonomous laboratory for the accelerated synthesis of novel materials Nature (IF 64.8) Pub Date : 2023-11-29 Nathan J. Szymanski, Bernardus Rendy, Yuxing Fei, Rishi E. Kumar, Tanjin He, David Milsted, Matthew J. McDermott, Max Gallant, Ekin Dogus Cubuk, Amil Merchant, Haegyeom Kim, Anubhav Jain, Christopher J. Bartel, Kristin Persson, Yan Zeng, Gerbrand Ceder
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On-surface synthesis of aromatic cyclo[10]carbon and cyclo[14]carbon Nature (IF 64.8) Pub Date : 2023-11-29 Luye Sun, Wei Zheng, Wenze Gao, Faming Kang, Mali Zhao, Wei Xu
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FOXP3 recognizes microsatellites and bridges DNA through multimerization Nature (IF 64.8) Pub Date : 2023-11-29 Wenxiang Zhang, Fangwei Leng, Xi Wang, Ricardo N. Ramirez, Jinseok Park, Christophe Benoist, Sun Hur
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Identification of constrained sequence elements across 239 primate genomes Nature (IF 64.8) Pub Date : 2023-11-29 Lukas F. K. Kuderna, Jacob C. Ulirsch, Sabrina Rashid, Mohamed Ameen, Laksshman Sundaram, Glenn Hickey, Anthony J. Cox, Hong Gao, Arvind Kumar, Francois Aguet, Matthew J. Christmas, Hiram Clawson, Maximilian Haeussler, Mareike C. Janiak, Martin Kuhlwilm, Joseph D. Orkin, Thomas Bataillon, Shivakumara Manu, Alejandro Valenzuela, Juraj Bergman, Marjolaine Rouselle, Felipe Ennes Silva, Lidia Agueda, Julie
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A resonant sextuplet of sub-Neptunes transiting the bright star HD 110067 Nature (IF 64.8) Pub Date : 2023-11-29 R. Luque, H. P. Osborn, A. Leleu, E. Pallé, A. Bonfanti, O. Barragán, T. G. Wilson, C. Broeg, A. Collier Cameron, M. Lendl, P. F. L. Maxted, Y. Alibert, D. Gandolfi, J.-B. Delisle, M. J. Hooton, J. A. Egger, G. Nowak, M. Lafarga, D. Rapetti, J. D. Twicken, J. C. Morales, I. Carleo, J. Orell-Miquel, V. Adibekyan, R. Alonso, A. Alqasim, P. J. Amado, D. R. Anderson, G. Anglada-Escudé, T. Bandy, T. Bárczy
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Landscape dynamics and the Phanerozoic diversification of the biosphere Nature (IF 64.8) Pub Date : 2023-11-29 Tristan Salles, Laurent Husson, Manon Lorcery, Beatriz Hadler Boggiani
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Exploring large-scale entanglement in quantum simulation Nature (IF 64.8) Pub Date : 2023-11-29 Manoj K. Joshi, Christian Kokail, Rick van Bijnen, Florian Kranzl, Torsten V. Zache, Rainer Blatt, Christian F. Roos, Peter Zoller
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Genetic continuity and change among the Indigenous peoples of California Nature (IF 64.8) Pub Date : 2023-11-22 Nathan Nakatsuka, Brian Holguin, Jakob Sedig, Paul E. Langenwalter, John Carpenter, Brendan J. Culleton, Cristina García-Moreno, Thomas K. Harper, Debra Martin, Júpiter Martínez-Ramírez, Antonio Porcayo-Michelini, Vera Tiesler, M. Elisa Villapando-Canchola, Alejandro Valdes Herrera, Kim Callan, Elizabeth Curtis, Aisling Kearns, Lora Iliev, Ann Marie Lawson, Matthew Mah, Swapan Mallick, Adam Micco,
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Trans-vaccenic acid reprograms CD8+ T cells and anti-tumour immunity Nature (IF 64.8) Pub Date : 2023-11-22 Hao Fan, Siyuan Xia, Junhong Xiang, Yuancheng Li, Matthew O. Ross, Seon Ah Lim, Fan Yang, Jiayi Tu, Lishi Xie, Urszula Dougherty, Freya Q. Zhang, Zhong Zheng, Rukang Zhang, Rong Wu, Lei Dong, Rui Su, Xiufen Chen, Thomas Althaus, Peter A. Riedell, Patrick B. Jonker, Alexander Muir, Gregory B. Lesinski, Sarwish Rafiq, Madhav V. Dhodapkar, Wendy Stock, Olatoyosi Odenike, Anand A. Patel, Joseph Opferman
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Repeated Omicron exposures override ancestral SARS-CoV-2 immune imprinting Nature (IF 64.8) Pub Date : 2023-11-22 Ayijiang Yisimayi, Weiliang Song, Jing Wang, Fanchong Jian, Yuanling Yu, Xiaosu Chen, Yanli Xu, Sijie Yang, Xiao Niu, Tianhe Xiao, Jing Wang, Lijuan Zhao, Haiyan Sun, Ran An, Na Zhang, Yao Wang, Peng Wang, Lingling Yu, Zhe Lv, Qingqing Gu, Fei Shao, Ronghua Jin, Zhongyang Shen, Xiaoliang Sunney Xie, Youchun Wang, Yunlong Cao
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Imaging quantum oscillations and millitesla pseudomagnetic fields in graphene Nature (IF 64.8) Pub Date : 2023-11-22 Haibiao Zhou, Nadav Auerbach, Matan Uzan, Yaozhang Zhou, Nasrin Banu, Weifeng Zhi, Martin E. Huber, Kenji Watanabe, Takashi Taniguchi, Yuri Myasoedov, Binghai Yan, Eli Zeldov
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Structural insights into cytokine cleavage by inflammatory caspase-4 Nature (IF 64.8) Pub Date : 2023-11-22 Pascal Devant, Ying Dong, Julian Mintseris, Weiyi Ma, Steven P. Gygi, Hao Wu, Jonathan C. Kagan
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Recognition and maturation of IL-18 by caspase-4 noncanonical inflammasome Nature (IF 64.8) Pub Date : 2023-11-22 Xuyan Shi, Qichao Sun, Yanjie Hou, Huan Zeng, Yong Cao, Mengqiu Dong, Jingjin Ding, Feng Shao
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Epithelial IFNγ signalling and compartmentalized antigen presentation orchestrate gut immunity Nature (IF 64.8) Pub Date : 2023-11-22 Ankit Malik, Deepika Sharma, Raúl Aguirre-Gamboa, Shaina McGrath, Sarah Zabala, Christopher Weber, Bana Jabri
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Intermediate conformations of CD4-bound HIV-1 Env heterotrimers Nature (IF 64.8) Pub Date : 2023-11-22 Kim-Marie A. Dam, Chengcheng Fan, Zhi Yang, Pamela J. Bjorkman
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Hopfion rings in a cubic chiral magnet Nature (IF 64.8) Pub Date : 2023-11-22 Fengshan Zheng, Nikolai S. Kiselev, Filipp N. Rybakov, Luyan Yang, Wen Shi, Stefan Blügel, Rafal E. Dunin-Borkowski
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Autoimmune amelogenesis imperfecta in patients with APS-1 and coeliac disease Nature (IF 64.8) Pub Date : 2023-11-22 Yael Gruper, Anette S. B. Wolff, Liad Glanz, Frantisek Spoutil, Mihaela Cuida Marthinussen, Adriana Osickova, Yonatan Herzig, Yael Goldfarb, Goretti Aranaz-Novaliches, Jan Dobeš, Noam Kadouri, Osher Ben-Nun, Amit Binyamin, Bar Lavi, Tal Givony, Razi Khalaila, Tom Gome, Tomáš Wald, Blanka Mrazkova, Carmel Sochen, Marine Besnard, Shifra Ben-Dor, Ester Feldmesser, Elisaveta M. Orlova, Csaba Hegedűs, István
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Aligning climate scenarios to emissions inventories shifts global benchmarks Nature (IF 64.8) Pub Date : 2023-11-22 Matthew J. Gidden, Thomas Gasser, Giacomo Grassi, Nicklas Forsell, Iris Janssens, William F. Lamb, Jan Minx, Zebedee Nicholls, Jan Steinhauser, Keywan Riahi
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Methane throughout the atmosphere of the warm exoplanet WASP-80b Nature (IF 64.8) Pub Date : 2023-11-22 Taylor J. Bell, Luis Welbanks, Everett Schlawin, Michael R. Line, Jonathan J. Fortney, Thomas P. Greene, Kazumasa Ohno, Vivien Parmentier, Emily Rauscher, Thomas G. Beatty, Sagnick Mukherjee, Lindsey S. Wiser, Martha L. Boyer, Marcia J. Rieke, John A. Stansberry
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Phages overcome bacterial immunity via diverse anti-defence proteins Nature (IF 64.8) Pub Date : 2023-11-22 Erez Yirmiya, Azita Leavitt, Allen Lu, Adelyn E. Ragucci, Carmel Avraham, Ilya Osterman, Jeremy Garb, Sadie P. Antine, Sarah E. Mooney, Samuel J. Hobbs, Philip J. Kranzusch, Gil Amitai, Rotem Sorek
It was recently shown that bacteria employ, apart from CRISPR-Cas and restriction systems, a considerable diversity of phage resistance systems1–4, but it is largely unknown how phages cope with this multilayered bacterial immunity. Here, we analyzed groups of closely related Bacillus phages that showed differential sensitivity to bacterial defense systems, and discovered four distinct families of
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Structural basis of Gabija anti-phage defence and viral immune evasion Nature (IF 64.8) Pub Date : 2023-11-22 Sadie P. Antine, Alex G. Johnson, Sarah E. Mooney, Azita Leavitt, Megan L. Mayer, Erez Yirmiya, Gil Amitai, Rotem Sorek, Philip J. Kranzusch
Bacteria encode hundreds of diverse defense systems that protect from viral infection and inhibit phage propagation1–5. Gabija is one of the most prevalent anti-phage defense systems, occurring in >15% of all sequenced bacterial and archaeal genomes1,6,7, but the molecular basis of how Gabija defends cells from viral infection remains poorly understood. Here we use X-ray crystallography and cryo-EM
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HIV-1 Env trimers asymmetrically engage CD4 receptors in membranes Nature (IF 64.8) Pub Date : 2023-11-22 Wenwei Li, Zhuan Qin, Elizabeth Nand, Michael W. Grunst, Jonathan R. Grover, Julian W. Bess, Jeffrey D. Lifson, Michael B. Zwick, Hemant D. Tagare, Pradeep D. Uchil, Walther Mothes
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Sequential appetite suppression by oral and visceral feedback to the brainstem Nature (IF 64.8) Pub Date : 2023-11-22 Truong Ly, Jun Y. Oh, Nilla Sivakumar, Sarah Shehata, Naymalis La Santa Medina, Heidi Huang, Zhengya Liu, Wendy Fang, Chris Barnes, Naz Dundar, Brooke C. Jarvie, Anagh Ravi, Olivia K. Barnhill, Chelsea Li, Grace R. Lee, Jaewon Choi, Heeun Jang, Zachary A. Knight
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Structural insights into intron catalysis and dynamics during splicing Nature (IF 64.8) Pub Date : 2023-11-22 Ling Xu, Tianshuo Liu, Kevin Chung, Anna Marie Pyle
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Porin-independent accumulation in Pseudomonas enables antibiotic discovery Nature (IF 64.8) Pub Date : 2023-11-22 Emily J. Geddes, Morgan K. Gugger, Alfredo Garcia, Martin Garcia Chavez, Myung Ryul Lee, Sarah J. Perlmutter, Christoph Bieniossek, Laura Guasch, Paul J. Hergenrother
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Bacterial cGAS senses a viral RNA to initiate immunity Nature (IF 64.8) Pub Date : 2023-11-15 Dalton V. Banh, Cameron G. Roberts, Adrian Morales-Amador, Brandon A. Berryhill, Waqas Chaudhry, Bruce R. Levin, Sean F. Brady, Luciano A. Marraffini
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SO2, silicate clouds, but no CH4 detected in a warm Neptune Nature (IF 64.8) Pub Date : 2023-11-15 Achrène Dyrek, Michiel Min, Leen Decin, Jeroen Bouwman, Nicolas Crouzet, Paul Mollière, Pierre-Olivier Lagage, Thomas Konings, Pascal Tremblin, Manuel Güdel, John Pye, Rens Waters, Thomas Henning, Bart Vandenbussche, Francisco Ardevol Martinez, Ioannis Argyriou, Elsa Ducrot, Linus Heinke, Gwenael Van Looveren, Olivier Absil, David Barrado, Pierre Baudoz, Anthony Boccaletti, Christophe Cossou, Alain
WASP-107b is a warm ( ~ 740 K) transiting planet with a Neptune-like mass of ~ 30.5 M⊕ and Jupiter-like radius of ~ 0.94 RJ 1,2 whose extended atmosphere is eroding 3. Previous observations showed evidence for water vapour and a thick high-altitude condensate layer in WASP-107b’s atmosphere 4,5. Recently, photochemically produced sulphur dioxide (SO2) was detected in the atmosphere of a hot ( ~ 1,200
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Computational prediction of complex cationic rearrangement outcomes Nature (IF 64.8) Pub Date : 2023-11-15 Tomasz Klucznik, Leonidas-Dimitrios Syntrivanis, Sebastian Baś, Barbara Mikulak-Klucznik, Martyna Moskal, Sara Szymkuć, Jacek Mlynarski, Louis Gadina, Wiktor Beker, Martin D. Burke, Konrad Tiefenbacher, Bartosz A. Grzybowski
Recent years have seen revived interest in computer-assisted organic synthesis1,2. The use of reaction-network and neural-network algorithms which can plan multi-step synthetic pathways have revolutionized this field1,3-7, including examples leading to advanced natural products6,7. Such methods typically operate on full, literature-derived “substrate(s)-to-product” reaction rules and cannot be easily
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Single-cell, whole-embryo phenotyping of mammalian developmental disorders Nature (IF 64.8) Pub Date : 2023-11-15 Xingfan Huang, Jana Henck, Chengxiang Qiu, Varun K. A. Sreenivasan, Saranya Balachandran, Oana V. Amarie, Martin Hrabě de Angelis, Rose Yinghan Behncke, Wing-Lee Chan, Alexandra Despang, Diane E. Dickel, Madeleine Duran, Annette Feuchtinger, Helmut Fuchs, Valerie Gailus-Durner, Natja Haag, Rene Hägerling, Nils Hansmeier, Friederike Hennig, Cooper Marshall, Sudha Rajderkar, Alessa Ringel, Michael Robson
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Imaging inter-valley coherent order in magic-angle twisted trilayer graphene Nature (IF 64.8) Pub Date : 2023-11-15 Hyunjin Kim, Youngjoon Choi, Étienne Lantagne-Hurtubise, Cyprian Lewandowski, Alex Thomson, Lingyuan Kong, Haoxin Zhou, Eli Baum, Yiran Zhang, Ludwig Holleis, Kenji Watanabe, Takashi Taniguchi, Andrea F. Young, Jason Alicea, Stevan Nadj-Perge
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The social and structural architecture of the yeast protein interactome Nature (IF 64.8) Pub Date : 2023-11-15 André C. Michaelis, Andreas-David Brunner, Maximilian Zwiebel, Florian Meier, Maximilian T. Strauss, Isabell Bludau, Matthias Mann
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Kinetic magnetism in triangular moiré materials Nature (IF 64.8) Pub Date : 2023-11-15 L. Ciorciaro, T. Smoleński, I. Morera, N. Kiper, S. Hiestand, M. Kroner, Y. Zhang, K. Watanabe, T. Taniguchi, E. Demler, A. İmamoğlu
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Embryo-scale reverse genetics at single-cell resolution Nature (IF 64.8) Pub Date : 2023-11-15 Lauren M. Saunders, Sanjay R. Srivatsan, Madeleine Duran, Michael W. Dorrity, Brent Ewing, Tor H. Linbo, Jay Shendure, David W. Raible, Cecilia B. Moens, David Kimelman, Cole Trapnell
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Minutes-duration optical flares with supernova luminosities Nature (IF 64.8) Pub Date : 2023-11-15 Anna Y. Q. Ho, Daniel A. Perley, Ping Chen, Steve Schulze, Vik Dhillon, Harsh Kumar, Aswin Suresh, Vishwajeet Swain, Michael Bremer, Stephen J. Smartt, Joseph P. Anderson, G. C. Anupama, Supachai Awiphan, Sudhanshu Barway, Eric C. Bellm, Sagi Ben-Ami, Varun Bhalerao, Thomas de Boer, Thomas G. Brink, Rick Burruss, Poonam Chandra, Ting-Wan Chen, Wen-Ping Chen, Jeff Cooke, Michael W. Coughlin, Kaustav
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Aligned grains and scattered light found in gaps of planet-forming disk Nature (IF 64.8) Pub Date : 2023-11-15 Ian W. Stephens, Zhe-Yu Daniel Lin, Manuel Fernández-López, Zhi-Yun Li, Leslie W. Looney, Haifeng Yang, Rachel Harrison, Akimasa Kataoka, Carlos Carrasco-Gonzalez, Satoshi Okuzumi, Ryo Tazaki
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Stress granules plug and stabilize damaged endolysosomal membranes Nature (IF 64.8) Pub Date : 2023-11-15 Claudio Bussi, Agustín Mangiarotti, Christian Vanhille-Campos, Beren Aylan, Enrica Pellegrino, Natalia Athanasiadi, Antony Fearns, Angela Rodgers, Titus M. Franzmann, Anđela Šarić, Rumiana Dimova, Maximiliano G. Gutierrez
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The extracellular matrix dictates regional competence for tumour initiation Nature (IF 64.8) Pub Date : 2023-11-15 Nordin Bansaccal, Pauline Vieugue, Rahul Sarate, Yura Song, Esmeralda Minguijon, Yekaterina A. Miroshnikova, Dagmar Zeuschner, Amandine Collin, Justine Allard, Dan Engelman, Anne-Lise Delaunois, Mélanie Liagre, Leona de Groote, Evy Timmerman, Delphi Van Haver, Francis Impens, Isabelle Salmon, Sara A. Wickström, Alejandro Sifrim, Cédric Blanpain
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Trait-based sensitivity of large mammals to a catastrophic tropical cyclone Nature (IF 64.8) Pub Date : 2023-11-15 Reena H. Walker, Matthew C. Hutchinson, Justine A. Becker, Joshua H. Daskin, Kaitlyn M. Gaynor, Meredith S. Palmer, Dominique D. Gonçalves, Marc E. Stalmans, Jason Denlinger, Paola Bouley, Mercia Angela, Antonio Paulo, Arjun B. Potter, Nikhail Arumoogum, Francesca Parrini, Jason P. Marshal, Robert M. Pringle, Ryan A. Long
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CD201+ fascia progenitors choreograph injury repair Nature (IF 64.8) Pub Date : 2023-11-15 Donovan Correa-Gallegos, Haifeng Ye, Bikram Dasgupta, Aydan Sardogan, Safwen Kadri, Ravinder Kandi, Ruoxuan Dai, Yue Lin, Robert Kopplin, Disha Shantaram Shenai, Juliane Wannemacher, Ryo Ichijo, Dongsheng Jiang, Maximilian Strunz, Meshal Ansari, Illias Angelidis, Herbert B. Schiller, Thomas Voltz, Hans-Günther Machens, Yuval Rinkevich
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Quantum gas mixtures and dual-species atom interferometry in space Nature (IF 64.8) Pub Date : 2023-11-15 Ethan R. Elliott, David C. Aveline, Nicholas P. Bigelow, Patrick Boegel, Sofia Botsi, Eric Charron, José P. D’Incao, Peter Engels, Timothé Estrampes, Naceur Gaaloul, James R. Kellogg, James M. Kohel, Norman E. Lay, Nathan Lundblad, Matthias Meister, Maren E. Mossman, Gabriel Müller, Holger Müller, Kamal Oudrhiri, Leah E. Phillips, Annie Pichery, Ernst M. Rasel, Charles A. Sackett, Matteo Sbroscia,
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Potentiating glymphatic drainage minimizes post-traumatic cerebral oedema Nature (IF 64.8) Pub Date : 2023-11-15 Rashad Hussain, Jeffrey Tithof, Wei Wang, Arokoruba Cheetham-West, Wei Song, Weiguo Peng, Björn Sigurdsson, Daehyun Kim, Qian Sun, Sisi Peng, Virginia Plá, Douglas H. Kelley, Hajime Hirase, Jorge A. Castorena-Gonzalez, Pia Weikop, Steven A. Goldman, Michael J. Davis, Maiken Nedergaard
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Dynamic diagnosis of metamaterials through laser-induced vibrational signatures Nature (IF 64.8) Pub Date : 2023-11-15 Yun Kai, Somayajulu Dhulipala, Rachel Sun, Jet Lem, Washington DeLima, Thomas Pezeril, Carlos M. Portela
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Quasi-experimental evaluation of a nationwide diabetes prevention programme Nature (IF 64.8) Pub Date : 2023-11-15 Julia M. Lemp, Christian Bommer, Min Xie, Felix Michalik, Anant Jani, Justine I. Davies, Till Bärnighausen, Sebastian Vollmer, Pascal Geldsetzer
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Illuminating protein space with a programmable generative model Nature (IF 64.8) Pub Date : 2023-11-15 John B. Ingraham, Max Baranov, Zak Costello, Karl W. Barber, Wujie Wang, Ahmed Ismail, Vincent Frappier, Dana M. Lord, Christopher Ng-Thow-Hing, Erik R. Van Vlack, Shan Tie, Vincent Xue, Sarah C. Cowles, Alan Leung, João V. Rodrigues, Claudio L. Morales-Perez, Alex M. Ayoub, Robin Green, Katherine Puentes, Frank Oplinger, Nishant V. Panwar, Fritz Obermeyer, Adam R. Root, Andrew L. Beam, Frank J. Poelwijk
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Clostridioides difficile ferrosome organelles combat nutritional immunity Nature (IF 64.8) Pub Date : 2023-11-15 Hualiang Pi, Rong Sun, James R. McBride, Angela R. S. Kruse, Katherine N. Gibson-Corley, Evan S. Krystofiak, Maribeth R. Nicholson, Jeffrey M. Spraggins, Qiangjun Zhou, Eric P. Skaar
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Ultralow-resistance electrochemical capacitor for integrable line filtering Nature (IF 64.8) Pub Date : 2023-11-15 Yajie Hu, Mingmao Wu, Fengyao Chi, Guobin Lai, Puying Li, Wenya He, Bing Lu, Chuanxin Weng, Jinguo Lin, Fengen Chen, Huhu Cheng, Feng Liu, Lan Jiang, Liangti Qu
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Vision-controlled jetting for composite systems and robots Nature (IF 64.8) Pub Date : 2023-11-15 Thomas J. K. Buchner, Simon Rogler, Stefan Weirich, Yannick Armati, Barnabas Gavin Cangan, Javier Ramos, Scott T. Twiddy, Davide M. Marini, Aaron Weber, Desai Chen, Greg Ellson, Joshua Jacob, Walter Zengerle, Dmitriy Katalichenko, Chetan Keny, Wojciech Matusik, Robert K. Katzschmann
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Stepwise requirements for polymerases δ and θ in theta-mediated end joining Nature (IF 64.8) Pub Date : 2023-11-15 Susanna Stroik, Juan Carvajal-Garcia, Dipika Gupta, Alyssa Edwards, Adam Luthman, David W. Wyatt, Rachel L. Dannenberg, Wanjuan Feng, Thomas A. Kunkel, Gaorav P. Gupta, Mark Hedglin, Richard Wood, Sylvie Doublié, Eli Rothenberg, Dale A. Ramsden
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Continuous symmetry breaking in a trapped-ion spin chain Nature (IF 64.8) Pub Date : 2023-11-15 Lei Feng, Or Katz, Casey Haack, Mohammad Maghrebi, Alexey V. Gorshkov, Zhexuan Gong, Marko Cetina, Christopher Monroe
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Predicting multiple conformations via sequence clustering and AlphaFold2 Nature (IF 64.8) Pub Date : 2023-11-13 Hannah K. Wayment-Steele, Adedolapo Ojoawo, Renee Otten, Julia M. Apitz, Warintra Pitsawong, Marc Hömberger, Sergey Ovchinnikov, Lucy Colwell, Dorothee Kern
AlphaFold2 (AF2) 1 has revolutionized structural biology by accurately predicting single structures of proteins. However, a protein’s biological function often depends on multiple conformational substates2, and disease-causing point mutations often cause population changes within these substates3,4. We demonstrate that clustering a multiple sequence alignment (MSA) by sequence similarity enables AF2
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Integrated global assessment of the natural forest carbon potential Nature (IF 64.8) Pub Date : 2023-11-13 Lidong Mo, Constantin M. Zohner, Peter B. Reich, Jingjing Liang, Sergio de Miguel, Gert-Jan Nabuurs, Susanne S. Renner, Johan van den Hoogen, Arnan Araza, Martin Herold, Leila Mirzagholi, Haozhi Ma, Colin Averill, Oliver L. Phillips, Javier G. P. Gamarra, Iris Hordijk, Devin Routh, Meinrad Abegg, Yves C. Adou Yao, Giorgio Alberti, Angelica M. Almeyda Zambrano, Braulio Vilchez Alvarado, Esteban Alvarez-Dávila
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Single-cell CRISPR screens in vivo map T cell fate regulomes in cancer Nature (IF 64.8) Pub Date : 2023-11-15 Peipei Zhou, Hao Shi, Hongling Huang, Xiang Sun, Sujing Yuan, Nicole M. Chapman, Jon P. Connelly, Seon Ah Lim, Jordy Saravia, Anil KC, Shondra M. Pruett-Miller, Hongbo Chi
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m1A in CAG repeat RNA binds to TDP-43 and induces neurodegeneration Nature (IF 64.8) Pub Date : 2023-11-08 Yuxiang Sun, Hui Dai, Xiaoxia Dai, Jiekai Yin, Yuxiang Cui, Xiaochuan Liu, Gwendolyn Gonzalez, Jun Yuan, Feng Tang, Nan Wang, Alexandra E. Perlegos, Nancy M. Bonini, X. William Yang, Weifeng Gu, Yinsheng Wang
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Observing the primary steps of ion solvation in helium droplets Nature (IF 64.8) Pub Date : 2023-11-08 Simon H. Albrechtsen, Constant A. Schouder, Alberto Viñas Muñoz, Jeppe K. Christensen, Christian Engelbrecht Petersen, Martí Pi, Manuel Barranco, Henrik Stapelfeldt
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Role play with large language models Nature (IF 64.8) Pub Date : 2023-11-08 Murray Shanahan, Kyle McDonell, Laria Reynolds
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Phosphorus-bearing molecules PO and PN at the edge of the Galaxy Nature (IF 64.8) Pub Date : 2023-11-08 L. A. Koelemay, K. R. Gold, L. M. Ziurys
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Tuning sterol extraction kinetics yields a renal-sparing polyene antifungal Nature (IF 64.8) Pub Date : 2023-11-08 Arun Maji, Corinne P. Soutar, Jiabao Zhang, Agnieszka Lewandowska, Brice E. Uno, Su Yan, Yogesh Shelke, Ganesh Murhade, Evgeny Nimerovsky, Collin G. Borcik, Andres S. Arango, Justin D. Lange, Jonnathan P. Marin-Toledo, Yinghuan Lyu, Keith L. Bailey, Patrick J. Roady, Jordan T. Holler, Anuj Khandelwal, Anna M. SantaMaria, Hiram Sanchez, Praveen R. Juvvadi, Gina Johns, Michael J. Hageman, Joanna Krise