A series of novel biaryl ester derivatives were synthesized using N-heterocyclic carbene (NHC) catalysis, and their efficacy against Tobacco Mosaic Virus (TMV) was assessed. Biological assays showed that some derivatives displayed significant antiviral properties, with compound (rac)-3l exhibiting the most potent in vivo antiviral protective activity against TMV (EC50 = 105.8 μg/mL), outperforming

In an attempt to discover natural-product-derived novel green herbicides, 26 novel 3-carene-based acylhydrazone compounds were designed and synthesized. Their chemical structures were characterized by FTIR, NMR, HRMS, NOESY, and single-crystal X-ray diffraction. The herbicidal activity of the target compounds was evaluated, and the target compound AH18 exhibited good herbicidal activity against the

Rice blast, caused by Magnaporthe oryzae, is a major threat to global rice production. This study explores the antifungal potential of the immunosuppressant FK506 and identifies its target protein, MoFpr1 (FK506-binding protein 1B). FK506 inhibited mycelial growth, appressorium formation, and pathogenicity of M. oryzae in an MoFpr1-dependent manner. Mechanistic analyses revealed that FK506 impairs

Eucommia ulmoides Oliver is a valuable medicinal plant renowned for its diverse, health-promoting compounds. However, its slow growth and low content of bioactive constituents limit its pharmaceutical development. In this study, a novel endophytic fungus exhibiting multiple in vitro plant growth-promoting traits was isolated from E. ulmoides leaves and identified as Aspergillus sp. Y232. We explored

Atrazine (ATZ), a widely used herbicide, induces neurotoxicity by disrupting microglial efferocytosis─a critical process for maintaining central nervous system homeostasis. Lycopene (LYC), a natural antioxidant, exhibits protective potential against pesticide-induced damage, yet its role in ATZ-impaired efferocytosis remains unexplored. Here, we demonstrate that LYC mitigates ATZ-induced hippocampal

Phytoviruses depend on intercellular movement to implement systemic infection, which is controlled by several biological macromolecules from pathogens and hosts. Strategically interrupting this process holds promise for plant protection, while few traffic inhibitors are being discovered. In this study, natural coniferylaldehyde is implemented to lead optimization involving dithioacetal modification

Biodegradable microplastics (BMPs) have been widely detected in soils due to their widespread production and utilization. However, their impacts on rhizosphere microbial consortia and plant metabolic adaptation mechanisms have been insufficiently characterized. Here, two typical BMPs, polybutylene adipate-co-terephthalate and polyhydroxybutyrate, were selected to assess the effects of individual and

The ongoing discovery of effective agrochemicals remains one of the key activities to meet crop protection needs. Computer-aided molecular design, combined with systematic bioassay screening, was employed to identify novel herbicides targeting dihydroorotate dehydrogenase (DHODH). The hydroxypyrazole scaffold previously reported was also recognized by our virtual screening system, based on which its

Pesticide stress significantly reduces crop productivity. This study investigated wheat-fava bean intercropping combined with nano zinc oxide (nZnO) application as a strategy to alleviate pyroxasulfone (PYR) stress on fava beans. We examined the effect on plant growth, the rhizosphere microenvironment, and PYR degradation. The combined treatment effectively reduced the PYR toxicity and promoted fava