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Importance of Green and Sustainable Chemistry in the Chemical Industry Org. Process Res. Dev. (IF 3.317) Pub Date : 2022-06-23 Juan Colberg, King Kuok (Mimi) Hii, Stefan G. Koenig
This article references 14 other publications. This article has not yet been cited by other publications. This article references 14 other publications.
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Process Intensive Synthesis of Propofol Enabled by Continuous Flow Chemistry Org. Process Res. Dev. (IF 3.317) Pub Date : 2022-06-23 Laurent Vinet, Lorenzo Di Marco, Vanessa Kairouz, André B. Charette
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Development and Scale-Up of a Copper-Catalyzed Sulfamidation Coupling Reaction Org. Process Res. Dev. (IF 3.317) Pub Date : 2022-06-23 Neil K. Adlington, Paul S. Siedlecki, Ian Derrick, Simon D. Yates, Andrew D. Campbell, Paula Tomlin, Thomas Langer
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A Techno-economic Assessment of a Biocatalytic Chiral Amine Production Process Integrated with In Situ Membrane Extraction Org. Process Res. Dev. (IF 3.317) Pub Date : 2022-06-14 Jie Yang, Anita Buekenhoudt, Miet Van Dael, Patricia Luis, Yamini Satyawali, Robert Malina, Sebastien Lizin
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Fixed Bed Continuous Hydrogenations in Trickle Flow Mode: A Pharmaceutical Industry Perspective Org. Process Res. Dev. (IF 3.317) Pub Date : 2022-06-14 Edward Masson, Erin M. Maciejewski, Katherine M. P. Wheelhouse, Lee J. Edwards
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Development of an Ene Reductase-Based Biocatalytic Process for the Production of Flavor Compounds Org. Process Res. Dev. (IF 3.317) Pub Date : 2022-06-14 Athena Papadopoulou, Christin Peters, Sonja Borchert, Kerstin Steiner, Rebecca Buller
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Cost-Efficient, Multigram Scalable Synthesis of Shelf-Stable Electrophilic (Phenylsulfonyl)difluoromethylating Reagents Org. Process Res. Dev. (IF 3.317) Pub Date : 2022-06-13 Enzo Nobile, Jean-Pierre Hébert, Thomas Castanheiro, Alain Ledoux, Tatiana Besset
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Practical Ferrioxalate Actinometry for the Determination of Photon Fluxes in Production-Oriented Photoflow Reactors Org. Process Res. Dev. (IF 3.317) Pub Date : 2022-06-10 Bavo Vandekerckhove, Nicola Piens, Bert Metten, Christian V. Stevens, Thomas S. A. Heugebaert
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A Novel and Practical Synthesis of Mavorixafor Org. Process Res. Dev. (IF 3.317) Pub Date : 2022-06-09 Weiyuan Liu, Siju Bi, Ting Tian, Ting Zhou, Kuaile Lin, Weicheng Zhou
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Easy Removal of Triphenylphosphine Oxide from Reaction Mixtures by Precipitation with CaBr2 Org. Process Res. Dev. (IF 3.317) Pub Date : 2022-06-09 Antonio Rodríguez Hergueta
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Some Items of Interest to Process R&D Chemists and Engineers Org. Process Res. Dev. (IF 3.317) Pub Date : 2022-06-07 Sylvain Guizzetti, James A. Schwindeman, David S. B. Daniels, James J. Douglas, Alex Kosanovich, Wenyi Zhao, Christopher B. Kelly, John Knight
This article has not yet been cited by other publications.
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Large-Scale Amidations in Process Chemistry: Practical Considerations for Reagent Selection and Reaction Execution Org. Process Res. Dev. (IF 3.317) Pub Date : 2022-06-07 Javier Magano
This review describes the practical aspects involved in the implementation of large-scale amidations in process chemistry. Coupling reagent, base, additive, and solvent selections are critically analyzed to highlight their pros and cons. Other important factors to be considered on large scale, such as atom economy, cost, safety, and toxicity, are also examined. These concepts are then showcased through
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Regioisomer Formation with Agmatine Guanidino Group, Its Implications for Agmatine Peptide Cyclization, and Application of Bis-Boc-Agmatine Org. Process Res. Dev. (IF 3.317) Pub Date : 2022-06-03 Yi Yang, Lena Hansen
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Analytical Tools Integrated in Continuous-Flow Reactors: Which One for What? Org. Process Res. Dev. (IF 3.317) Pub Date : 2022-06-01 Mireia Rodriguez-Zubiri, François-Xavier Felpin
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Reconsidering the Safety Hazards Associated with Peroxide Formation in 2-Propanol Org. Process Res. Dev. (IF 3.317) Pub Date : 2022-05-31 Megan A. Cismesia, Suhelen Vásquez Céspedes
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Copper-Catalyzed Addition of Alcohols to Carbodiimides: Oxygen as an Accelerant Org. Process Res. Dev. (IF 3.317) Pub Date : 2022-05-31 Lucille A. Wells, Michael R. Gau, Michael B. Peddicord, Kirsten F. Bostwick, Marisa C. Kozlowski, Michael J. Zacuto
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Recent Advances in the Solid- and Solution-Phase Synthesis of Peptides and Proteins Using Microflow Technology Org. Process Res. Dev. (IF 3.317) Pub Date : 2022-05-27 Hisashi Masui, Shinichiro Fuse
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Multigram Scale Synthesis of Piperarborenines C-E Org. Process Res. Dev. (IF 3.317) Pub Date : 2022-05-26 Jason M. Lenihan, Matthew J. Mailloux, Aaron B. Beeler
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Correction to “Thermal Instability and Associated Potential Safety Hazards of Rhodium(I) Precatalyst Complexes with Weakly Coordinated Ligands” Org. Process Res. Dev. (IF 3.317) Pub Date : 2022-05-25 Min Sheng, Qiang Yang, Darren Huff, Andrew G. Schafer, Craig Tucker, Daniel Valco
The first author’s name has been corrected to Min Sheng on pp 1054 and 1062. This article has not yet been cited by other publications.
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Cu-Mediated Ullmann-Type Cross-Coupling and Industrial Applications in Route Design, Process Development, and Scale-up of Pharmaceutical and Agrochemical Processes Org. Process Res. Dev. (IF 3.317) Pub Date : 2022-05-24 Qiang Yang, Yinsong Zhao, Dawei Ma
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Enantioselective Synthesis of the Chiral Pyrrolidine Fragment of Upadacitinib via Chiral Auxiliary Directed Diastereoselective 1,3-Dipolar Cycloaddition Org. Process Res. Dev. (IF 3.317) Pub Date : 2022-05-20 Magesh Sampath, Sembian Ruso Jayaraman, Vishnuvardhan Reddy Eda, Rajendar Potham, Rajeev Rehani Budhdev, Saikat Sen, Rakeshwar Bandichhor, Srinivas Oruganti
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Discovery and Process Development of a Scalable Biocatalytic Kinetic Resolution toward Synthesis of a Sterically Hindered Chiral Ketone Org. Process Res. Dev. (IF 3.317) Pub Date : 2022-05-17 Nicole Wamser, Hao Wu, Frederic Buono, Anthony Brundage, Francesco Ricci, Jon C. Lorenz, Jun Wang, Nizar Haddad, Joshua Paolillo, Joyce C. Leung, Heewon Lee, Azad Hossain
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Highly Enantioselective Hydroxylation of 3-Arylpropanenitriles to Access Chiral β-Hydroxy Nitriles by Engineering of P450pyr Monooxygenase Org. Process Res. Dev. (IF 3.317) Pub Date : 2022-05-10 Guo-Zhong Deng, Xu Zhou, Quan-Xiang Yu, Xue-Qing Mou, Miao An, Hai-Bo Cui, Xiao-Jian Zhou, Nan-Wei Wan, Zhi Li, Yong-Zheng Chen
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Fit-for-Purpose Synthesis of an Aza-Cryptophycin Analogue as the Payload for an Antibody–Drug Conjugate Org. Process Res. Dev. (IF 3.317) Pub Date : 2022-05-10 Audrey Bendelac, Françoise Benedetti, Valerie Doublet-Decabras, Rachel Lokovi, François Decalogne, Antony Bigot
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Synthesis of 5-Nitrotetrazolate via the Aqueous Oxidation of 5-Aminotetrazole Org. Process Res. Dev. (IF 3.317) Pub Date : 2022-05-11 Jake E. Zuckerman, Tim D. Manship, Dawson M. Smith, Davin G. Piercey
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Integration of Liquid–Liquid Biphasic Flow Alkylation and Continuous Crystallization Using Taylor Vortex Flow Reactors Org. Process Res. Dev. (IF 3.317) Pub Date : 2022-05-10 Masahiro Hosoya, Masashi Tanaka, Atsushi Manaka, Shogo Nishijima, Naoki Tsuno
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Some Items of Interest to Process R&D Chemists and Engineers Org. Process Res. Dev. (IF 3.317) Pub Date : 2022-05-10 Andrei A. Zlota, Paul F. Richardson, Alan Steven, Robert B. Kargbo, Carlos Mateos, James P. Phelan, Rik Oost, John Knight
This article has not yet been cited by other publications.
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Manufacturable Process of a Novel EGFR Inhibitor (Larotinib) for the Treatment of ESCC Org. Process Res. Dev. (IF 3.317) Pub Date : 2022-05-09 Weihong Zhang, Zhiming Su, Haiwang Liu, Yingjun Zhang, Weiliang Ye, Dahua Peng, Hongpeng Xie, Hongtao Peng, Zhihong Peng, Wanrong Dong, Delie An
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Missing Link: Enabling Loading of 2-Chlorotrityl Chloride Resin in N-Butylpyrrolidinone as a Green Solvent Org. Process Res. Dev. (IF 3.317) Pub Date : 2022-05-05 John Lopez, Janina Beck, Christoph Bucher, Arne Berthelmann, Spyridon Markos, Stefan Eissler
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Optimization of Metal Affinity Ketoreductase Immobilization for Application in Batch and Flow Processes Org. Process Res. Dev. (IF 3.317) Pub Date : 2022-05-04 Alessandra Basso, Maria S. Brown, Alvaro Cruz-Izquierdo, Carlos A. Martinez, Simona Serban
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Side-Chain Unprotected Fmoc-Arg/His/Tyr-OH Couplings and Their Application in Solid-Phase Peptide Synthesis through a Minimal-Protection/Green Chemistry Strategy Org. Process Res. Dev. (IF 3.317) Pub Date : 2022-05-04 Yi Yang, Lena Hansen, Per Ryberg
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Melting Effect on the Thermal Hazard of Anthraquinone Dyes Waste: Based on the Thermal Decomposition Characteristics and Quantum Mechanics Org. Process Res. Dev. (IF 3.317) Pub Date : 2022-05-02 Wen-qian Wu, Ze-yuan Xia, Wang-hua Chen, Li-ping Chen, Hua-bo Li, Zi-chao Guo
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Online and In Situ Monitoring of the Exchange, Transmetalation, and Cross-Coupling of a Negishi Reaction Org. Process Res. Dev. (IF 3.317) Pub Date : 2022-04-28 Thomas C. Malig, Archana Kumar, Kenji L. Kurita
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Synthesis of 5-Substituted Tetrazoles: Reaction of Azide Salts with Organonitriles Catalyzed by Trialkylammonium Salts in Non-polar Media Org. Process Res. Dev. (IF 3.317) Pub Date : 2022-04-28 Sarath C. Sarngadharan, Josh Aronson, Carol Gelbaum, Kris Griffith, Jonathan Faris, Azhar B. Moihdeen, Mikhil Patel, Maryellen Malone, Kent Richman, Charles A. Eckert, Charles L. Liotta, Pamela Pollet
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Selective Photochemical Continuous Flow Benzylic Monochlorination Org. Process Res. Dev. (IF 3.317) Pub Date : 2022-04-27 Robbie Radjagobalou, Miguel Imbratta, Julie Bergraser, Marion Gaudeau, Gildas Lyvinec, Dominique Delbrayelle, Olivier Jentzer, Jérémy Roudin, Benjamin Laroche, Stéphanie Ognier, Michael Tatoulian, Janine Cossy, Pierre-Georges Echeverria
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Correction to “Effective Phosphorylation of 2,2′-Methylene-bis(4,6-di-tert-butyl) Phenol in Continuous Flow Reactors” Org. Process Res. Dev. (IF 3.317) Pub Date : 2022-04-27 Hanlin Yao, Li Wan, Xiaoyu Zhao, Yahui Guo, Jian Zhou, Xiaofan Bo, Yuxin Mao, Zhong Xin
In the published article, Scheme 2 contained an error. The corrected scheme is given here. This article has not yet been cited by other publications.
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Highly Efficient and Selective Hydrogenation of Sugars Catalyzed by Ru-MACHO-BH: Practical Synthesis of Sugar Alcohols Org. Process Res. Dev. (IF 3.317) Pub Date : 2022-04-25 Hiroki Ishikawa, Taichiro Touge, Wataru Kuriyama, Michio Kida, Kazuhiko Matsumura
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Electrochemical Oxidation of Alcohols Using Nickel Oxide Hydroxide as Heterogeneous Electrocatalyst in Batch and Continuous Flow Org. Process Res. Dev. (IF 3.317) Pub Date : 2022-04-24 Wolfgang Jud, Chase A. Salazar, Joseph Imbrogno, Jenson Verghese, Steven M. Guinness, Jean-Nicolas Desrosiers, C. Oliver Kappe, David Cantillo
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Thermal and Kinetic Research on a Highly Exothermic Condensation Reaction by Powerful Calorimeters Org. Process Res. Dev. (IF 3.317) Pub Date : 2022-04-21 Hanlin Yao, Li Wan, Yahui Guo, Yuxin Mao, Zhong Xin
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Development of a Process to a 4-Arylated 2-Methylisoquinolin-1(2H)-one for the Treatment of Solid Tumors: Lessons in Ortho-Bromination, Selective Solubility, Pd Deactivation, and Form Control Org. Process Res. Dev. (IF 3.317) Pub Date : 2022-04-20 David N. Primer, Kelvin Yong, Antonio Ramirez, Matthew Kreilein, Antonio C. Ferretti, Antonio M. Ruda, Nadia Fleary-Roberts, Jonathan D. Moseley, Siân M. Forsyth, Graham R. Evans, John F. Traverse
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Evaluation of the Thermal Hazard of the Oxidation Reaction in the Synthesis of 3,4-Bis(4-nitrofurazan-3-yl)furoxan Org. Process Res. Dev. (IF 3.317) Pub Date : 2022-04-19 Yanlong Zhu, Li Ding, Luping Xu, Hai Chang, Xiaofeng Wang, Xiaoling Zhang
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Continuous Processing of Concentrated Organolithiums in Flow Using Static and Dynamic Spinning Disc Reactor Technologies Org. Process Res. Dev. (IF 3.317) Pub Date : 2022-04-19 Ulrich Wietelmann, Johannes Klösener, Peter Rittmeyer, Stefan Schnippering, Henk Bats, Wouter Stam
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Flow Toolkit for Measuring Reaction Enthalpy and Application to Highly Exothermic Synthesis of Alkylaluminoxanes Org. Process Res. Dev. (IF 3.317) Pub Date : 2022-04-19 Mengbo Zhang, Yirong Feng, Linjin Lou, Haomiao Zhang, Jingdai Wang, Yongrong Yang
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Driving Aspirational Process Mass Intensity Using Simple Structure-Based Prediction Org. Process Res. Dev. (IF 3.317) Pub Date : 2022-04-18 Edward C. Sherer, Ansuman Bagchi, Birgit Kosjek, Kevin M. Maloney, Zhengwei Peng, Sandra A. Robaire, Robert P. Sheridan, Essam Metwally, Louis-Charles Campeau
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Efficient Synthesis of (S)-1-Boc-3-aminopiperidine in a Continuous Flow System Using ω-Transaminase-Immobilized Amino-Ethylenediamine-Modified Epoxide Supports Org. Process Res. Dev. (IF 3.317) Pub Date : 2022-04-15 Xiangxiang Wang, Youyu Xie, Zhicai Wang, Ke Zhang, Hualei Wang, Dongzhi Wei
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Application of the Polonovski Reaction: Scale-up of an Efficient and Environmentally Benign Opioid Demethylation Org. Process Res. Dev. (IF 3.317) Pub Date : 2022-04-13 Antonio M. Ruda, Sofia Papadouli, Vargini Thangavadivale, Jonathan D. Moseley
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Scaling up a C–H Borylation: Addressing the Safety Concerns of an Iridium-Catalyzed Process for Multikilo Scale Manufacture Org. Process Res. Dev. (IF 3.317) Pub Date : 2022-04-08 Amanda Jane Lyons, Adam Clarke, Heidi Fisk, Bethany Jackson, Peter R. Moore, Samantha Oke, Thomas O. Ronson, Rebecca E. Meadows
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Development of an Improved Synthetic Process of Clonazepam by Preventing the Formation of a Trimeric Compound in the Presence of HCl Org. Process Res. Dev. (IF 3.317) Pub Date : 2022-04-06 Xuezhi Gao, Jiajian Xu, Chunfeng Liu, Peng Peng, Chuanmeng Zhao, Mengke Chen, Pengcheng Qiu, Fuli Zhang
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Some Items of Interest to Process R&D Chemists and Engineers Org. Process Res. Dev. (IF 3.317) Pub Date : 2022-04-05 Sylvain Guizzetti, James A. Schwindeman, David S. B. Daniels, James J. Douglas, Alex Kosanovich, Wenyi Zhao, Christopher B. Kelly, John Knight
This article has not yet been cited by other publications.
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Determination of Purge Factors for Use in Oligonucleotide Control Strategies Org. Process Res. Dev. (IF 3.317) Pub Date : 2022-03-30 Yannick A. Fillon, Nadim Akhtar, Benjamin I. Andrews, David Benstead, Simon Breitler, Robert S. Gronke, Martin Olbrich, Jessica A. Stolee, Tobias Vandermeersch
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High-Yield Synthesis of Enantiopure 1,2-Amino Alcohols from l-Phenylalanine via Linear and Divergent Enzymatic Cascades Org. Process Res. Dev. (IF 3.317) Pub Date : 2022-03-28 Maria L. Corrado, Tanja Knaus, Ulrich Schwaneberg, Francesco G. Mutti
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Comparison of One-Dimensional and Two-Dimensional Population Balance Models for Optimization of a Crystallization Process for a Needle-Shaped Active Pharmaceutical Ingredient Org. Process Res. Dev. (IF 3.317) Pub Date : 2022-03-28 Tamar Rosenbaum, Victoria Mbachu, Niall Anthony Mitchell, John Francis Gamble, Patricia Cho, Joshua D. Engstrom
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High Yielding Continuous-Flow Synthesis of Norketamine Org. Process Res. Dev. (IF 3.317) Pub Date : 2022-03-26 Marcos Veguillas Hernando, Jonathan C. Moore, Rowena A. Howie, Richard A. Castledine, Samuel L. Bourne, Gareth N. Jenkins, Peter Licence, Martyn Poliakoff, Michael W. George
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Synthesis Optimization, Scale-Up, and Catalyst Screening Efforts toward the MGAT2 Clinical Candidate, BMS-963272 Org. Process Res. Dev. (IF 3.317) Pub Date : 2022-03-24 James Kempson, Xiaoping Hou, Jung-Hui Sun, Michael Wong, Joseph Pawluczyk, Jianqing Li, Subramaniam Krishnananthan, Eric M. Simmons, Yi Hsiao, Yi-Xin Li, Dawn Sun, Dauh-Rurng Wu, Wei Meng, Saleem Ahmad, Lidet Negash, Robert Brigance, Huji Turdi, Jon J. Hangeland, R. Michael Lawrence, Pratik Devasthale, Jeffrey A. Robl, Arvind Mathur
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Scale-Up of Diazonium Salts and Azides in a Three-Step Continuous Flow Sequence Org. Process Res. Dev. (IF 3.317) Pub Date : 2022-03-22 Hansjoerg Lehmann, Thomas Ruppen, Thomas Knoepfel
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Reaction of Irbesartan with Nitrous Acid Produces Irbesartan Oxime Derivatives, rather than N-Nitrosoirbesartan Org. Process Res. Dev. (IF 3.317) Pub Date : 2022-03-21 Jinsheng Lin, Qiang Zhou, Ru Jia, Wentao Liu, Huacui Hou, Jian Ma, Dan Li, Nuo Chen, Wenbin Chen, Jian Ye, Wenping Hu, Wenquan Zhu, Min Li
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Recent Advances in Enzyme Immobilization Utilizing Nanotechnology for Biocatalysis Org. Process Res. Dev. (IF 3.317) Pub Date : 2022-03-17 Kotchakorn T.sriwong, Tomoko Matsuda
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Binary Solvent Swap Processing in a Bubble Column in Batch and Continuous Modes Org. Process Res. Dev. (IF 3.317) Pub Date : 2022-03-16 Phillip Roche, Roderick C. Jones, Brian Glennon, Philip Donnellan
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Robust Analytical Methods for Monitoring the Formation of a Chiral Oxazaborolidine Catalyst Org. Process Res. Dev. (IF 3.317) Pub Date : 2022-03-16 Sloan Ayers, Gregory L. Beutner, Wei Ding, Carolyn Higman, Charles Pathirana, Robert Wethman
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Enzymatic Cascade in a Simultaneous, One-Pot Approach with In Situ Product Separation for the Asymmetric Production of (4S,5S)-Octanediol Org. Process Res. Dev. (IF 3.317) Pub Date : 2022-03-15 Jan-Dirk Spöring, William Graf von Westarp, Carina Ronja Kipp, Andreas Jupke, Dörte Rother
更新日期：2022-05-04
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