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Copper(I) Diphosphine Bifluoride Complexes as Efficient Preactivated Catalysts for Nucleophilic Addition on Unsaturated Functional Groups Org. Process Res. Dev. (IF 3.327) Pub Date : 2020-01-24 Corentin Rasson; Olivier Riant
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Evaluation of Sponge Metal Catalysts in a Trickle Bed Reactor for the Continuous Hydrogenation of an Aliphatic Nitro Intermediate Org. Process Res. Dev. (IF 3.327) Pub Date : 2020-01-24 Antonella Carangio; Lee J. Edwards; Eneritz Fernandez-Puertas; Jerome F. Hayes; Maciej Kucharski; Graham W. Rutherford; Katherine M. P. Wheelhouse; Glynn D. Williams
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A Perspective on Continuous Flow Chemistry in the Pharmaceutical Industry Org. Process Res. Dev. (IF 3.327) Pub Date : 2020-01-23 Marcus Baumann; Thomas S. Moody; Megan Smyth; Scott Wharry
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Thermodynamics and Kinetics of Click Reaction between Benzyl Azide and Different Alkynes by Microcalorimetry Org. Process Res. Dev. (IF 3.327) Pub Date : 2020-01-22 Xiaoyi Li; Bo Jin; Zhicheng Guo; Shijin Chu; Rufang Peng
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Comparing Gas–Liquid Segmented and Tube-in-Tube Setups for the Aerobic Dimerization of Desmethoxycarpacine with an Automated Flow Platform Org. Process Res. Dev. (IF 3.327) Pub Date : 2020-01-22 Ehu Camille Aka; Eric Wimmer; Elvina Barré; Daniel Cortés-Borda; Tchirioua Ekou; Lynda Ekou; Mireia Rodriguez-Zubiri; François-Xavier Felpin
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Systematic Investigation into the Formation of Significant Amounts of Unknown Impurity during Scale-up of NaBH4–I2 Mediated Reduction of Nitro-Amide Intermediate of Mirabegron# Org. Process Res. Dev. (IF 3.327) Pub Date : 2020-01-21 Dattatray G. Deshmukh; Mukund N. Bangal; Kaustubh A. Kalawade; Vijayavitthal T. Mathad
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Large-Scale Synthesis of the Glycine Schiff Base Ni(II) Complex Derived from (S)- and (R)-N-(2-Benzoyl-4-chlorophenyl)-1-[(3,4-dichlorophenyl)methyl]-2-pyrrolidinecarboxamide Org. Process Res. Dev. (IF 3.327) Pub Date : 2020-01-16 Todd T. Romoff; Bernardo G. Ignacio; Noel Mansour; Andrew B. Palmer; Christopher J. Creighton; Hidenori Abe; Hiroki Moriwaki; Jianlin Han; Hiroyuki Konno; Vadim A. Soloshonok
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Continuous Flow Photo-oxidations Using Supported Photocatalysts on Silica Org. Process Res. Dev. (IF 3.327) Pub Date : 2020-01-16 Vincent Blanchard; Zakariae Asbai; Kevin Cottet; Guillaume Boissonnat; Marc Port; Zacharias Amara
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Straightforward Access to 2-Iodoindolizines via Iodine-Mediated Cyclization of 2-Pyridylallenes Org. Process Res. Dev. (IF 3.327) Pub Date : 2020-01-16 Thibaut Martinez; Ismail Alahyen; Gilles Lemière; Virginie Mouriès-Mansuy; Louis Fensterbank
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Scalable Continuous Synthesis of Grignard Reagents from in Situ-Activated Magnesium Metal Org. Process Res. Dev. (IF 3.327) Pub Date : 2020-01-16 Gabriele Menges-Flanagan; Eva Deitmann; Lars Gössl; Christian Hofmann; Patrick Löb
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Lewis Acid-Catalyzed Racemization and Recycling of the Undesired (R)-Ketamine Org. Process Res. Dev. (IF 3.327) Pub Date : 2020-01-14 Shenghua Gao; Xuezhi Gao; Houyong Li; Anjiang Yang; Zhezhou Yang; Fuli Zhang
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Crystallization-Induced Diastereoisomer Transformation of Dihydroartemisinic Aldehyde with the Betti Base Org. Process Res. Dev. (IF 3.327) Pub Date : 2020-01-14 Andrea Zanetti; Pauline Chaumont-Olive; Geoffrey Schwertz; Marllon Nascimento de Oliveira; Mario Andrés Gomez Fernandez; Zacharias Amara; Janine Cossy
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Safe Scale-up of an Oxygen-Releasing Cleavage of Evans Oxazolidinone with Hydrogen Peroxide Org. Process Res. Dev. (IF 3.327) Pub Date : 2020-01-11 Andrew W. Glace; Benjamin M. Cohen; Darryl D. Dixon; Gregory L. Beutner; Dale Vanyo; Fulya Akpinar; Victor Rosso; Kenneth J. Fraunhoffer; Albert J. DelMonte; Edgar Santana; Christopher Wilbert; Frank Gallo; William Bartels
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General User Guide for Partitioning of Tetraalkylammonium and Tetraalkylphosphonium Salts: Impacts of Cation, Anion, and Solvent Org. Process Res. Dev. (IF 3.327) Pub Date : 2020-01-10 Richard J. Fox; Jun Qiu
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Some Items of Interest to Process R&D Chemists and Engineers Org. Process Res. Dev. (IF 3.327) Pub Date : 2020-01-09 Paul Richardson; Alan Steven; Robert Kargbo; Christopher C. Nawrat; Carlos Mateos; Andrei A. Zlota; John Knight
Email addresses: [email protected]; [email protected]; [email protected]; [email protected]; [email protected]; [email protected]; [email protected]. This article has not yet been cited by other publications.
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Pd(OH)2/C, a Practical and Efficient Catalyst for the Carboxylation of Benzylic Bromides with Carbon Monoxide Org. Process Res. Dev. (IF 3.327) Pub Date : 2020-01-08 Anne-Marie Wakuluk-Machado; Damien F. Dewez; Hajar Baguia; Miguel Imbratta; Pierre-Georges Echeverria; Gwilherm Evano
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A Short Review of Synthetic Routes for the Antiepileptic Drug (R)-Lacosamide Org. Process Res. Dev. (IF 3.327) Pub Date : 2020-01-08 Eswar K. Aratikatla; Asish K. Bhattacharya
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A Versatile Method of Ambient-Temperature Solvent Removal Org. Process Res. Dev. (IF 3.327) Pub Date : 2020-01-07 Igor V. Kolesnichenko; Galina Z. Goloverda; Vladimir L. Kolesnichenko
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A Flow Process Built upon a Batch Foundation—Preparation of a Key Amino Alcohol Intermediate via Multistage Continuous Synthesis Org. Process Res. Dev. (IF 3.327) Pub Date : 2020-01-06 John Jin Lim; Kenneth Arrington; Anna L. Dunn; David C. Leitch; Ian Andrews; Neil R. Curtis; Mark J. Hughes; Daniel R. Tray; Charles E. Wade; Matthew P. Whiting; Charles Goss; Yangmu Chloe Liu; Brian M. Roesch
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Control Strategy Expectations in Early Clinical Phase Synthetic Oncology Programs: Two Global Regulatory Case Studies Org. Process Res. Dev. (IF 3.327) Pub Date : 2020-01-04 Scott W. Roberts; Nina S. Cauchon; Minhui Ma; Jeroen Bezemer; Xichen Zhang; Eric Weilage; Omari Anson
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A Fit-for-Purpose Synthesis of (R)-2-Methylazepane Org. Process Res. Dev. (IF 3.327) Pub Date : 2020-01-02 Sylvain Guizzetti; Antoine Michaut; Guillaume Federspiel; Julien Eymard; Isabelle Caron; Sabrina Quatrevaux; Etienne Daras; Sandrine Jolly; Jérôme Guillemont; David Lançois
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Thermal Stability and Explosive Hazard Assessment of Diazo Compounds and Diazo Transfer Reagents Org. Process Res. Dev. (IF 3.327) Pub Date : 2020-01-01 Sebastian P. Green; Katherine M. Wheelhouse; Andrew D. Payne; Jason P. Hallett; Philip W. Miller; James A. Bull
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Large, Highly Modular Narrow-Gap Electrolytic Flow Cell and Application in Dehydrogenative Cross-Coupling of Phenols Org. Process Res. Dev. (IF 3.327) Pub Date : 2019-12-27 Barbara Gleede; Maximilian Selt; Christoph Gütz; Andreas Stenglein; Siegfried R. Waldvogel
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On-Line Analysis of the Heterogeneous Pd-Catalyzed Transfer Hydrogenation of p-Nitrophenol in Water with Formic Acid in a Flow Reactor Org. Process Res. Dev. (IF 3.327) Pub Date : 2019-12-26 Xiaotong Zhan; Sabine Michaud-Chevallier; Damien Hérault; Françoise Duprat
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Third-Generation Method for High-Throughput Quantification of Trace Palladium by Color or Fluorescence Org. Process Res. Dev. (IF 3.327) Pub Date : 2019-12-26 Lydia Lukomski; Ivanna Pohorilets; Kazunori Koide
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One-Pot Synthesis of 1-[(Triisopropylsilyl)ethynyl]-1,2-benziodoxol-3(1H)-one (TIPS-EBX): Process Safety Assessment and Impact of Impurities on Product Stability Org. Process Res. Dev. (IF 3.327) Pub Date : 2019-12-24 Durga Prasad Hari; Paola Caramenti; Lionel Schouwey; Miyeon Chang; Stefano Nicolai; Donald Bachert; Timothy Wright; Chuck Orella; Jerome Waser
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Efficient Resolution of Racemic Guaifenesin via Batch-Preferential Crystallization Processes Org. Process Res. Dev. (IF 3.327) Pub Date : 2019-12-20 Francesca Cascella; Erik Temmel; Andreas Seidel-Morgenstern; Heike Lorenz
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Process Development for the Rhodium-Catalyzed Reductive Amination in a Thermomorphic Multiphase System Org. Process Res. Dev. (IF 3.327) Pub Date : 2019-12-17 Kai U. Künnemann; Jonas Bianga; Ricarda Scheel; Thomas Seidensticker; Jens M. Dreimann; Dieter Vogt
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Continuous Hydrogenolysis of N-Diphenylmethyl Groups in a Micropacked-Bed Reactor Org. Process Res. Dev. (IF 3.327) Pub Date : 2019-12-17 Jiacheng Tu; Le Sang; Han Cheng; Ning Ai; Jisong Zhang
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Process Optimization, Product Profile Mapping, and Intensification of 1,1-Diamino-2,2-dinitroethylene Org. Process Res. Dev. (IF 3.327) Pub Date : 2019-12-16 Pandurang M. Jadhav; Radhakrishnan Sarangapani; Rajendra S. Patil; Raj K. Pandey
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A Sustainable 1-Pot, 3-Step Synthesis of Boscalid Using Part per Million Level Pd Catalysis in Water Org. Process Res. Dev. (IF 3.327) Pub Date : 2019-12-13 Balaram S. Takale; Ruchita R. Thakore; Rushil Mallarapu; Fabrice Gallou; Bruce H. Lipshutz
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Some Items of Interest to Process R&D Chemists and Engineers Org. Process Res. Dev. (IF 3.327) Pub Date : 2019-12-11 Wenyi Zhao; Sylvain Guizzetti; James A. Schwindeman; David S. B. Daniels; James J. Douglas; Sylvain Petit; John Knight
E-mail addresses: [email protected]; [email protected]; [email protected]; [email protected]; [email protected]; [email protected]. This article has not yet been cited by other publications.
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Catalytic Intermolecular C(sp3)–H Amination with Sulfamates for the Asymmetric Synthesis of Amines Org. Process Res. Dev. (IF 3.327) Pub Date : 2019-12-11 Ali Nasrallah, Yanis Lazib, Vincent Boquet, Benjamin Darses, Philippe Dauban
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Investigation of Nucleation under High-Shear Conditions for a Pharmaceutical Compound in an Unseeded System Org. Process Res. Dev. (IF 3.327) Pub Date : 2019-12-10 Pablo M. Martin-Soladana, Moiz Diwan, Huayu Li, Fredrik L. Nordstrom, Ahmad Sheikh
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Efficient Multikilogram Synthesis of a VLA-4 Antagonist via a Povarov Reaction Org. Process Res. Dev. (IF 3.327) Pub Date : 2019-12-10 Patrick Cerfontaine, Frank Driessens, Marie-France Deltent, Sylvain Petit
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Surfactant Technology: With New Rules, Designing New Sequences Is Required! Org. Process Res. Dev. (IF 3.327) Pub Date : 2019-12-10 Daniel J. Lippincott, Evan Landstrom, Margery Cortes-Clerget, Bruce H. Lipshutz, Klaus Buescher, Robert Schreiber, Corinne Durano, Michael Parmentier, Ning Ye, Bin Wu, Min Shi, Hongwei Yang, Martin Andersson, Fabrice Gallou
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Development of a Quality Controllable and Scalable Process for the Preparation of 7,8-Difluoro-6,11-dihydrodibenzo[b,e]thiepin-11-ol: A Key Intermediate for Baloxavir Marboxil Org. Process Res. Dev. (IF 3.327) Pub Date : 2019-12-09 Zihong Zhou, Zhongqing Wang, Jingping Kou, Shuming Wu, Junrong Zhang, Xi Yuan, Xiwei Wu, Chuan-hua Li, Gaohong Liao
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Safe and Scalable Continuous Flow Azidophenylselenylation of Galactal to Prepare Galactosamine Building Blocks Org. Process Res. Dev. (IF 3.327) Pub Date : 2019-12-09 Mónica Guberman, Bartholomäus Pieber, Peter H. Seeberger
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Gram-Scale Antibody–Drug Conjugate Synthesis by Site-Specific Chemical Conjugation: AJICAP First Generation Org. Process Res. Dev. (IF 3.327) Pub Date : 2019-12-05 Yutaka Matsuda, Kei Yamada, Tatsuya Okuzumi, Brian A. Mendelsohn
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Cyclopropyl Thioethers, New Inputs for Palladium Catalyzed Ring Opening of Cyclopropanes Org. Process Res. Dev. (IF 3.327) Pub Date : 2019-12-05 Sudipta Ponra, Aude Nyadanu, Na Pan, Elodie Martinand-Lurin, Alexandra Savy, Maxime Vitale, Laurent El Kaim, Laurence Grimaud
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Continuous-Flow Synthesis of the Azo Pigment Yellow 14 Using a Three-Stream Micromixing Process Org. Process Res. Dev. (IF 3.327) Pub Date : 2019-12-05 Fa-Jun Wang, Jin-Pei Huang, Jian-Hong Xu
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Multikilogram Synthesis of a Potent Dual Bcl-2/Bcl-xL Antagonist. 1. Manufacture of the Acid Moiety and Development of Some Key Reactions Org. Process Res. Dev. (IF 3.327) Pub Date : 2019-12-05 Christophe Hardouin, Sandrine Baillard, François Barière, Chloé Copin, Anthony Craquelin, Solenn Janvier, Sylvain Lemaitre, Stéphane Le Roux, Olivier Russo, Sébastien Samson
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Application of Selective Crystallization Methods To Isolate the Metastable Polymorphs of Paracetamol: A Review Org. Process Res. Dev. (IF 3.327) Pub Date : 2019-12-04 Patrı́cia C. Cruz, Fernando A. Rocha, António M. Ferreira
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Multikilogram Synthesis of a Potent Dual Bcl-2/Bcl-xL Antagonist. 2. Manufacture of the 1,3-Diamine Moiety and Improvement of the Final Coupling Reaction Org. Process Res. Dev. (IF 3.327) Pub Date : 2019-12-03 Christophe Hardouin, Sandrine Baillard, François Barière, Anthony Craquelin, Mathieu Grandjean, Solenn Janvier, Stéphane Le Roux, Christine Penloup, Olivier Russo
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Cerium(III) Chloride-Mediated Stereoselective Reduction of a 4-Substituted Cyclohexanone Using NaBH4 Org. Process Res. Dev. (IF 3.327) Pub Date : 2019-12-03 Prantik Maity, Manjunath Gujjar, Raghukumar Vellingiri, Thirumalai Lakshminarasimhan, Albert J. DelMonte, Ian S. Young, Martin D. Eastgate, Rajappa Vaidyanathan
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Development of Continuous Filtration in a Novel Continuous Filtration Carousel Integrated with Continuous Crystallization Org. Process Res. Dev. (IF 3.327) Pub Date : 2019-12-02 Yiqing C. Liu, András Domokos, Simon Coleman, Paul Firth, Zoltan K. Nagy
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Population Balance Modeling To Predict Particle Size Distribution upon Scale-Up of a Combined Antisolvent and Cooling Crystallization of an Active Pharmaceutical Ingredient Org. Process Res. Dev. (IF 3.327) Pub Date : 2019-12-02 Tamar Rosenbaum, Li Tan, Michael Dummeldinger, Niall Mitchell, Joshua Engstrom
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Overcoming Chemical Challenges in the Solid-Phase Synthesis of High-Purity GnRH Antagonist Degarelix. Part 1. Org. Process Res. Dev. (IF 3.327) Pub Date : 2019-12-02 Ivan Guryanov, Andrea Orlandin, Angelo Viola, Barbara Biondi, Denis Badocco, Fernando Formaggio, Antonio Ricci, Walter Cabri
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Iron-Catalyzed Intra-intermolecular Aminoazidation of Alkenes Org. Process Res. Dev. (IF 3.327) Pub Date : 2019-11-27 Sandra Abi Fayssal, Alessandro Giungi, Farouk Berhal, Guillaume Prestat
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A Single Quadrupole Compact Mass Spectrometer Enabling Early Stage Synthetic Optimization of Verubecestat (MK-8931) Org. Process Res. Dev. (IF 3.327) Pub Date : 2019-11-22 Daniel Zewge, Xiaodong Bu, Li Zhang, David Thaisrivongs, Yanke Xu, Xiaoyi Gong
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Diffusion-Enhanced Amide Bond Formation on a Solid Support Org. Process Res. Dev. (IF 3.327) Pub Date : 2019-11-21 Johnny N. Naoum, Israel Alshanski, Agata Gitlin-Domagalska, Moshe Bentolila, Chaim Gilon, Mattan Hurevich
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Experimental Estimation of Primary and Secondary Nucleation Kinetics of Antisolvent Crystallization As Measured by Induction Time Org. Process Res. Dev. (IF 3.327) Pub Date : 2019-11-15 Takanori Kodera, Masanori Kobari, Izumi Hirasawa
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A Continuous Stirred-Tank Reactor (CSTR) Cascade for Handling Solid-Containing Photochemical Reactions Org. Process Res. Dev. (IF 3.327) Pub Date : 2019-11-15 Alexander Pomberger, Yiming Mo, Kakasaheb Y. Nandiwale, Victor L. Schultz, Rohit Duvadie, Richard I. Robinson, Erhan I. Altinoglu, Klavs F. Jensen
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Stereospecific Amination of Mesylated Cyclobutanol in Continuous Flow Org. Process Res. Dev. (IF 3.327) Pub Date : 2019-11-14 Matthieu Tissot, Jérôme Jacq, Patrick Pasau
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Mapping the Separation Landscape of Pharmaceuticals: Rapid and Efficient Scale-Up of Preparative Purifications Enabled by Computer-Assisted Chromatographic Method Development Org. Process Res. Dev. (IF 3.327) Pub Date : 2019-11-12 Raffeal Bennett, Imad A. Haidar Ahmad, Jimmy DaSilva, Margaret Figus, Kari Hullen, Fuh-Rong Tsay, Alexey A. Makarov, Benjamin F. Mann, Erik L. Regalado
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Potential Safety Hazards Associated with Pd-Catalyzed Cross-Coupling Reactions Org. Process Res. Dev. (IF 3.327) Pub Date : 2019-11-12 Qiang Yang, Nicholas R. Babij, Steffen Good
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Scale-Up of the Manufacturing Process To Produce Docetaxel-Loaded mPEG-b-p(HPMA-Bz) Block Copolymer Micelles for Pharmaceutical Applications Org. Process Res. Dev. (IF 3.327) Pub Date : 2019-11-12 Jaleesa Bresseleers, Mahsa Bagheri, Gert Storm, Josbert M. Metselaar, Wim E. Hennink, Silvie A. Meeuwissen, Jan C. M. van Hest
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Highly Efficient Multigram Synthesis of Dibenzoazacyclooctyne (DBCO) without Chromatography Org. Process Res. Dev. (IF 3.327) Pub Date : 2019-11-12 Stuart A. McNelles, Julia L. Pantaleo, Alex Adronov
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Optimization and Gram-Scale Preparation of S-Trifluoromethyl Sulfoximines and Sulfilimino Iminiums, Powerful Reagents for the Late Stage Introduction of the CF3 Group Org. Process Res. Dev. (IF 3.327) Pub Date : 2019-11-11 Anne-Laure Barthelemy, Victor Certal, Guillaume Dagousset, Elsa Anselmi, Luc Bertin, Laurence Fabien, Bruno Salgues, Philippe Courtes, Christian Poma, Youssef El-Ahmad, Emmanuel Magnier
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Improving Powder Characteristics by Surface Modification Using Atomic Layer Deposition Org. Process Res. Dev. (IF 3.327) Pub Date : 2019-11-07 Cosima Hirschberg, Nikolaj Sølvkær Jensen, Johan Boetker, Anders Østergaard Madsen, Tommi O. Kääriäinen, Marja-Leena Kääriäinen, Pekka Hoppu, Steven M. George, Matti Murtomaa, Changquan Calvin Sun, Jens Risbo, Jukka Rantanen
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