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Nonclogging Liquid-Walled Continuous Flow Reactors Org. Process Res. Dev. (IF 3.1) Pub Date : 2025-02-12 Alejandro Mata, Caroline de Fraipont, Céline Hervieux, Lucas Giacchetti, Oicime Hadj-Sassi, Alexandra Bogicevic, Vincent Marichez, Thomas M. Hermans
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Flash Thermal Racemization of Chiral Amine in Continuous Flow: An Exploration of Reaction Space Using DoE and Multivariate Transient Flow Org. Process Res. Dev. (IF 3.1) Pub Date : 2025-02-11 Matthew J. Takle, Linden Schrecker, Benjamin J. Deadman, Joachim Dickhaut, Andy Wieja, Klaus Hellgardt, King Kuok Mimi Hii
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Some Items of Interest to Process R&D Chemists and Engineers Org. Process Res. Dev. (IF 3.1) Pub Date : 2025-02-10 James A. Schwindeman, Alex Kosanovich, Chad Ungarean, Timothy Kwok, Annabel Q. Ansel, James M. MacDougall, David Philip Day, Hannah L. D. Hayes, John Knight
This article has not yet been cited by other publications.
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Advancing Base Metal Catalysis: Development and Execution of a Ni-catalyzed Borylation/Pd-catalyzed Suzuki Telescoped Process Org. Process Res. Dev. (IF 3.1) Pub Date : 2025-02-10 Matthew V. Joannou, Matthew J. Goldfogel, Eric M. Simmons, Steven R. Wisniewski
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Systematic Assessment of Calibration Strategies in Spectroscopic Analysis: A Case Study of Paracetamol Crystallization Org. Process Res. Dev. (IF 3.1) Pub Date : 2025-02-07 Cha Yong Jong, Geordi Tristan, Lee Jun Jie Felix, Eunice Wan Qi Yeap, Srinivas Reddy Dubbaka, Harsha Nagesh Rao, Shin Yee Wong
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Stereoselective Synthesis of Mirogabalin via 1,4-Selective Addition of Lithioacetonitrile to Alkylidene Malonate Org. Process Res. Dev. (IF 3.1) Pub Date : 2025-02-07 Hidenori Ochiai, Taiki Mihara, Miwa Sasagawa, Akira Nishiyama
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Enhancing the Asymmetric Hydrogenation/Desymmetrization of an Achiral Lactone in the Synthesis of (+)-Biotin Org. Process Res. Dev. (IF 3.1) Pub Date : 2025-02-06 Werner Bonrath, Roman Goy, Achim Link, Felix Spindler, Jonathan A. Medlock, Marc-André Müller
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Flow Chemistry for Flowing Cross-Couplings: A Concise Overview Org. Process Res. Dev. (IF 3.1) Pub Date : 2025-02-06 Antonella Ilenia Alfano, Simona Barone, Margherita Brindisi
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Development and Scale-Up of an Enabling Synthetic Route to KTX-005, a Muscarinic Acetylcholine Receptor Agonist for the Potential Treatment of Schizophrenia Org. Process Res. Dev. (IF 3.1) Pub Date : 2025-02-05 Hanchao Zheng, Rui Zhang, Michel Leeman, Christopher R. H. Hale, Giorgio Attardo, Vijaya B. Gondi
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Development of a Scalable Synthesis of Casdatifan (AB521), a Potent, Selective, Clinical-Stage Inhibitor of HIF-2α Org. Process Res. Dev. (IF 3.1) Pub Date : 2025-02-05 Clayton Hardman, Artur K. Mailyan, Guillaume Mata, Joel W. Beatty, Samuel L. Drew, Jeremy Fournier, Jaroslaw Kalisiak, Brandon R. Rosen, Matthew Epplin, Balint Gal, Kai Yu, Zhang Wang, Karl Haelsig, Anh Tran, Manmohan R. Leleti, Jay P. Powers, Kenneth V. Lawson
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Glass-Facilitated Thermal Decomposition of Difluoromethoxy Arenes Org. Process Res. Dev. (IF 3.1) Pub Date : 2025-02-04 Sirun Yang, Tianhua Tang, Hayden Cheek, Joseph J. Topczewski, Eric Wiensch, Daniel J. Valco
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Continuous Synthesis of 1,3,2-Dioxathiolane 2,2-Dioxide (DTD) by Hydrogen Peroxide with Titanium Silicalite-1 Catalyst Using a Fixed-Bed Reactor Org. Process Res. Dev. (IF 3.1) Pub Date : 2025-02-03 Zunchao Liu, Tianlai Wang, Jianing Li, Xiangmin Tian, Cunfei Ma, Jingnan Zhao, Qingwei Meng
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Looking Inside the SPPS Reactor through a Refractometer: Online Quantification of the Resin Loading Org. Process Res. Dev. (IF 3.1) Pub Date : 2025-02-02 Beatriz G. de la Torre, Ndumiso Mthethwa, Srinivasa Rao Manne, John Lopez, Fernando Albericio
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NMR Detective Agency: Uncovering the Truth for Process Chemists Org. Process Res. Dev. (IF 3.1) Pub Date : 2025-01-31 Maria Victoria Silva Elipe
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Development of a Scalable Stereoselective Synthesis of Selected Potent ROMK Inhibitors Org. Process Res. Dev. (IF 3.1) Pub Date : 2025-01-30 Premsai Rai Neithnadka, Mahammed Kaspady Abdulla, Chiradeep Panja, Arunachalam Arumugam, Madhavan Kannan, Suresh Krishnamoorthy, Chidananda Mujoor Gopala, Prashantha Gunaga, Jeremy M. Richter, Muthalagu Vetrichelvan, Arvind Mathur, Anuradha Gupta
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Commercial Route Development of Sigma-2 Receptor Modulator, CT1812 Leveraging Photoflow, and HTS Technologies Org. Process Res. Dev. (IF 3.1) Pub Date : 2025-01-29 Steven A. Weissman, Christopher J. Kassl, Siead Zegar, Sarah M. Pound, Nori Ikemoto, William Reid, Thorsten Rosner, Xican He, Xianda Chen, Junfei Wen, Liang Han, Xiaojun Huang, Chaoyang Chen, Yuehui Liu, Prithvi Vangal, Hongkun Lin, David D. Ford, Yuan-Qing Fang
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Methodologies for the Formation of 2-Substituted Oxetanes: Synthesis of (S)-Oxetan-2-ylmethyl Tosylate Org. Process Res. Dev. (IF 3.1) Pub Date : 2025-01-29 Matthew Badland, Maria S. Brown, Nessa Carson, Douglas J. Critcher, Steven J. Fussell, Michael Hawksworth, Heather Ingram, Rebecca A. Johnson, Rajesh Kumar, Jinu S. Mathew, Laura McGivern, Philip Peach, Ben Pibworth, Alexandru I. Pop, Emily K. Rose, Nathan J. Rutland, Adam Scott, Steven J. R. Twiddle
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Adoption of Electrochemistry within the Pharmaceutical Industry: Insights from an Industry-Wide Survey Org. Process Res. Dev. (IF 3.1) Pub Date : 2025-01-27 Antonio C. Ferretti, Benjamin Cohen, Lin Deng, Moiz Diwan, Michael O. Frederick, Dan Lehnherr
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Application of an Interdisciplinary Approach to Form Selection in Drug Development Org. Process Res. Dev. (IF 3.1) Pub Date : 2025-01-25 Darren L. Reid, Margaret M. Faul, Vilmalí López-Mejías, Prashant Agarwal, Markus Bergauer, Laura E. Blue, Mary K. Chaves, John Chung, Melanie Cooke, Robert P. Farrell, James E. Huckle, Ron C. Kelly, Y.-H. Kiang, Weikun Li, Adrian Ortiz, Qiong Wu
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Applicability of Fluidized Bed Crystallization for Separation of Enantiomers Forming Needle-Shaped Crystals Org. Process Res. Dev. (IF 3.1) Pub Date : 2025-01-23 Jonathan Gänsch, Igor Gamm, Andreas Seidel-Morgenstern, Heike Lorenz
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A Confined Impinging Jet Reactor for High-Throughput Continuous Flow Mononitration of Salicylic Acid Org. Process Res. Dev. (IF 3.1) Pub Date : 2025-01-23 Muzammilanwar S. Khan, Tabrez R. Shaikh, Sphurti P. Kulkarni, Abhishek A. Patil, Amol A. Kulkarni
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Process Analytical Technology for Real-Time Monitoring of Pharmaceutical Bioconjugation Reactions Org. Process Res. Dev. (IF 3.1) Pub Date : 2025-01-22 Nicole M. Ralbovsky, Gunjan Dixit, Justin P. Lomont, Jay Desai, Cristina Butu, Anumita Saha-Shah, Emily Costello, Janelle Lukens, Michael Mazur, Patrick M. McHugh, Rodell C. Barrientos, Andrew Semple, Gregory J. Hughes, Rebecca Chmielowski, Sheng-Ching Wang, Bhumit A. Patel, Joseph P. Smith
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Some Items of Interest to Process R&D Chemists and Engineers Org. Process Res. Dev. (IF 3.1) Pub Date : 2025-01-21 Alan Steven, Carlos Mateos, Paul F. Richardson, Robert B. Kargbo, Thomas Verheyen, Christopher C. Nawrat, David S. B. Daniels, Alexandre Barthelme, John Knight
This article has not yet been cited by other publications.
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Quality Control for Incoming Raw Materials Beyond Identity and Purity: Case Studies from Recent Merck API Manufacturing Processes Org. Process Res. Dev. (IF 3.1) Pub Date : 2025-01-19 Nelo R. Rivera, Rekha Gangam, Rebecca Arvary, Taylor Behre, Zhiwei Chen, Erik D. Guetschow, Nadine Kuhl, Mingxiang Lin, Nastaran Salehi Marzijarani, Erin McCarthy, Ji Qi, Ben W. H. Turnbull, Tao Wang, Wenjun Liu
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Leveraging Supercritical Fluid Chromatography for Monitoring the Formation of Methanol Adducts of AR-LDD Antagonist BMS-986409 in Spray-Dried Dispersion Materials Org. Process Res. Dev. (IF 3.1) Pub Date : 2025-01-17 Brian Lingfeng He, Xuejun Xu, Leon Liang
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Synergizing Process Conditions, Water Sensitivity, and Kinetic Mechanisms to Optimize Sodium Salicylate Yield in Sodium Phenol Carboxylation Org. Process Res. Dev. (IF 3.1) Pub Date : 2025-01-17 Haodong Zhang, Junmei Zhang, Jingjing Ma, Maoqian Wu, Linbo Hu, Hongfu Chen, Zhenya Duan
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OPR&D: An Exceptional Legacy and Exciting Opportunities for the Future of Process Chemistry Org. Process Res. Dev. (IF 3.1) Pub Date : 2025-01-17 Margaret M. Faul
This article has not yet been cited by other publications.
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Development of the Crystallization Process for Rivaroxaban–Oxalic Acid Cocrystal Preparation Using a Combination of Phase Diagrams and In Situ Measurements Org. Process Res. Dev. (IF 3.1) Pub Date : 2025-01-15 Erika Hriňová, Igor Čerňa, Eliška Zmeškalová, Luděk Ridvan, Miroslav Šoóš
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Can a Simple Surrogate Model System Be Used to Develop a Continuous Flow Packed Bed Hydrogenation for a Complex Molecule? Org. Process Res. Dev. (IF 3.1) Pub Date : 2025-01-15 Stefano Martinuzzi, Martin Mex, Jelena Milic, Christopher A. Hone, C. Oliver Kappe
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Correction to “Development of an Optimized Process for 2,4-Dichloro-5-fluoroacetophenone: A Key Intermediate of Ciprofloxacin” Org. Process Res. Dev. (IF 3.1) Pub Date : 2025-01-15 Kai Yin, Youlan He, Hao Wu, Xubin He
The author Yiwei Zhang and his affiliation and funding should be removed from the original publication (DOI: 10.1021/acs.oprd.4c00208), which was published on July 24, 2024, due to a preexisting confidentiality agreement in relation to this work. The following funding should be removed from the original acknowledgment section: the National Natural Science Foundation of China (no. 21878047) and the
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A Continuous Hydrogenation Reactor Based on a Powdered Catalyst Enmeshed in an Expanded Poly(tetrafluoroethylene) Matrix Org. Process Res. Dev. (IF 3.1) Pub Date : 2025-01-14 Sean Breen, Purnima Barua, Yuan-Qing Fang, David D. Ford, Ali Hasan, Manish Joshi, Sara Mason, Kevin D. Nagy, Sifat bin Quadery, Grace Russell, Vladimiros Nikolakis, John D. Holcombe, Andrea Adamo, Lorenzo Milani
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Scaling Up Gas–Liquid Photo-Oxidations in Flow Using Rotor-Stator Spinning Disc Reactors and a High-Intensity Light Source Org. Process Res. Dev. (IF 3.1) Pub Date : 2025-01-14 Arnab Chaudhuri, Wouter F.C. de Groot, Jasper H.A. Schuurmans, Stefan D.A. Zondag, Alessia Bianchi, Koen P.L. Kuijpers, Rémy Broersma, Amin Delparish, Matthieu Dorbec, John van der Schaaf, Timothy Noël
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Achieving New Scales: The First Successful Pilot Plant Spherical Crystallization Org. Process Res. Dev. (IF 3.1) Pub Date : 2025-01-13 Stephanie C. Kosnik, Zeno Leuter, Kevin Schwickert
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Predicting Shock Sensitivity from Differential Scanning Calorimetry Data and Molecular Structure: Beyond the Yoshida Correlation Org. Process Res. Dev. (IF 3.1) Pub Date : 2025-01-13 Eric L. Margelefsky, Benjamin C. Dobson, Tao Chen, Nelson Lee Afanador
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Continuous Flow Telescopic Synthesis of 3-Methoxy Propiophenone by the Grignard Reaction Org. Process Res. Dev. (IF 3.1) Pub Date : 2025-01-10 Pranali Wankhede, Amol A. Kulkarni
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Therapeutic Peptides Control Strategy: Perspective on Current Industry Practices Org. Process Res. Dev. (IF 3.1) Pub Date : 2025-01-09 Brian W. Pack, Jeremy Manheim, Osama Chahrour, Brandon Wood, Limin Zhang, Ulf Vogel, Gracie Sheng
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Coupled-Batch Preferential Crystallization of Imeglimin Propionate on a 200 g Scale Org. Process Res. Dev. (IF 3.1) Pub Date : 2025-01-08 Leela Christian-Tabak, Koji Machida, Hideo Kawachi, Hiroaki Tanaka, Kazuki Hashimoto
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Characterization of Amorphous Ibrutinib Thermal Stability Org. Process Res. Dev. (IF 3.1) Pub Date : 2025-01-07 Dan Trunov, Jan Ižovský, Josef Beranek, Ondřej Dammer, Miroslav Šoóš
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Scalable Flow Electrosynthesis of Iminophosphoranes Org. Process Res. Dev. (IF 3.1) Pub Date : 2025-01-07 Dan Lehnherr, Longrui Chen, François Lévesque, Christopher Nietupski, Mark Weisel, Velabo Mdluli, Keith Mattern, Brittany M. Armstrong, Tao Chen, Ryan D. Cohen
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Review of the Synthesis of Timolol Maleate and Brimonidine Tartrate Drug Substances Used for the Treatment of Open-Angle Glaucoma Org. Process Res. Dev. (IF 3.1) Pub Date : 2025-01-04 Rajarathnam E. Reddy, Casey J. Maguire, Riley H. Hastings, Timothy L’Hommedieu, Michael C. Dennis, Haiyan L. Grady, Srinivas Peddapatla, Michael A. Haley, II
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Accelerating the Development of Sustainable Catalytic Processes through Data Science Org. Process Res. Dev. (IF 3.1) Pub Date : 2025-01-02 Jason M. Stevens, Jacob M. Ganley, Matthew J. Goldfogel, Ariel Furman, Steven R. Wisniewski
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Impurity Control Strategy of TMS-Triol in the Manufacture Development of Islatravir Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-12-22 Weidong Tong, Victor L. Schultz, Yingying Yang, Junyong Jo, Yu He, Marco E. Armenante, Sandra A. Robaire, Samantha A. Burgess, Yun Chen, Erica L. Schwalm, Matthew Gunsch, Xiao Wang, Qi Gao, Cyndi Q. He, Mikhail Reibarkh, Jeffrey T. Kuethe, Gregory J. Hughes
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Design, Development, and Scale-Up of a Stereoselective Synthesis of (1R,3R)-3-(3,5-Bis(trifluoromethyl)phenyl)-2,2-dichlorocyclopropane Carboxylic Acid Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-12-20 Pablo J. Cabrera, Fangzheng Li, Nakyen Choy, Tay Rosenthal, Steffen Good, Jeffrey Nissen, Avery Sader
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Thank You Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-12-20 Kai Rossen
My term as Editor-in-Chief for Organic Process Research & Development comes to an end in December 2024. I had the great honor to take over this role from Trevor Laird 10 years ago. Trevor had started the journal almost 20 years before and brought it into the family of American Chemical Society journals. The process chemistry community should be grateful to Trevor for having realized the need for a
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Predictive Methodology for Selecting the “Fit-for-Purpose” LC-HRMS Method for Quality Assessment in Peptide Synthesis Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-12-20 Pavan Ingle, Naveen Chandrasekar, Sumit Kumar, Cherukuri Venkata Apparao, Bichismita Sahu, Ravi P. Shah
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Three-Step Continuous Flow Synthesis of the Intermediate 4-Fluoro-2-methoxy-5-nitrophenol of Linzagolix Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-12-18 Tengfei Gong, Fei Ji, Yichen Shi, Yiyang Dong, Yu Xia, Fawen Wu, Xiaoming Zha
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Pd-Catalyzed Miyaura Borylations Mediated by Potassium Pivalate with Alcohol Cosolvents Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-12-17 Jacob M. Ganley, Senjie Ma, Cheng Peng, Eric M. Simmons
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Thermal Decomposition Properties and Thermal Hazard Assessment of Di(2,4-dichlorobenzoyl) Peroxide (DCBP) Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-12-17 Juanni Zhou, Chen Zhao, Lijing Zhang, Gang Tao
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Electrochemical Synthesis of an N-Arylpyridazinone: Discovery and Scale-Up Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-12-17 Chris C. Scarborough, Michael Dieckmann, Stanley C. S. Lai, Ralf Kohlbrenner, Matthias Lehmann, Claudio Battilocchio, Antonio Pedrina, Helmars Smits, Patrik Stenner, Tobias Stadtmueller
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Scalable Process Development of Ceritinib: Application of Statistical Design of Experiments Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-12-17 Shravan Kumar Komati, Amarendhar Manda, Sridhar Vasam, Gopal Chandru Senadi, Arthanareeswari Maruthapillai, Rakeshwar Bandichhor
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Overview and Recent Advances in the Purification and Isolation of Therapeutic Oligonucleotides Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-12-16 Aljaž Abe, Zdenko Časar
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Use of Population Balance Modelling to Derisk Scale-Up of an Integrated Crystallization–Wet Milling Process Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-12-16 Tamar Rosenbaum, Andrew Werneth, Shasad Sharif, Troy Wilkens, Benjamin Cohen, Joshua D. Engstrom, Antonio C. Ferretti, Yash Melkeri
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Synthesis, Characterization, and Control Strategies for Cabazitaxel-Related Substances at Scale Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-12-16 Amarendhar Manda, Shravan Kumar Komati, Debjit Basu, Gopal Chandru Senadi, Arthanareeswari Maruthapillai, Rakeshwar Bandichhor
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High-Throughput Experimentation Reveals Scope and Limitations of Selective Phosphine Reductants and Enables One-Pot mAb Reduction/Conjugation Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-12-13 Marion H. Emmert, Cuixian Yang, Eugene E. Kwan, Rebecca Chmielowski, Bruce Kilgore, Zachary L. VanAernum, Cecilia Bottecchia, Rodell C. Barrientos, Monica Haley, Kelly Raymond, Michael Rauscher, Zachary D. Dunn, Jay Desai
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Exploration for Chemical Filter Cartridges that Can Reduce Nitrogen Oxides, a Common Factor in the Formation of Nitrosamines Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-12-12 Ryota Nomura, Takahiko Taniguchi, Kazuya Suzuoki, Rintaro Yokoi, Kanenao Akasaki, Kyoko Hirai, Osamu Uchikawa
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Development of an Inherently Safe and Scalable Nickel-Catalyzed Borylation Process of an Aryl Sulfamate Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-12-12 Matthew V. Joannou, Christopher Y. Bemis, Geoffrey E. Purdum, Candice L. Joe, Kyle Eckenroad, Sharla L. Wood, Shasha Zhang, Amy A. Sarjeant, Rebecca A. Green, Jeffrey Nye, Steven R. Wisniewski, Scott A. Savage
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Robust Liquid Chromatography–Mass Spectrometry Determination of Deuterium Isotopologues for Quality Control of Deucravacitinib Using Nominal Mass Instrumentation Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-12-11 Cong Bi, Yueer Shi, Wei Ding, James Chadwick, Yan Zha, Su Pan, Paul Foy, Nicola Hulme, Brent Kleintop
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Can Ultrasound Replace Seeding in Flow Reactive Crystallization of an Aromatic Amine? Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-12-10 Biyu Zhang, Georgios D. Stefanidis, Tom Van Gerven
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Some Items of Interest to Process R&D Chemists and Engineers Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-12-10 James A. Schwindeman, Alex Kosanovich, Christopher B. Kelly, Timothy Kwok, Annabel Q. Ansel, James M. MacDougall, Jimmy Lauberteaux, David Philip Day, Elizabeth M. Dauncey, Sylvain Guizzetti, John Knight
This article has not yet been cited by other publications.
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Optimizing Industrial Solid-Phase Peptide Synthesis: Integration of Raman Spectroscopy as Process Analytical Technology Org. Process Res. Dev. (IF 3.1) Pub Date : 2024-12-10 Michael A. Stager, Carlos Peroza, Julien Villaumie, Christopher Bilham, Cameron Desmond, Marcus Harris, Ramya Sambasivan, Gary Rowe, Lin Chen, Charles Tucker