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Chemistry in Water Reproducibility Study: Learnings from a Precompetitive, Multicompany Collaboration Org. Process Res. Dev. (IF 3.4) Pub Date : 2024-03-15 Richard J. Fox, J. Daniel Bailey, Jennifer Victoriano Obligacion, Niginia Borlinghaus, Wilfried M. Braje, Xiaoyong Li, Subha Mukherjee, Adeline Schoen, Timothy B. Towne, Stella Vukelić
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Thermal Runaway Inhibition of Adipic Acid Green Synthesis Based on a Radical Chain Reaction Mechanism Org. Process Res. Dev. (IF 3.4) Pub Date : 2024-03-15 Jimi Su, Lei Ni, Zhen Cheng, Nan Chen, Peiqing Hao, Dongyan Yang, Yong Pan
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1,2,3-Triazole Synthesis: Development of Safe and Effective Batch and Continuous Manufacturing Processes Org. Process Res. Dev. (IF 3.4) Pub Date : 2024-03-12 Lei Song, Hwee Ting Ang, Jagadeesan Senthilperumal, Umamaheswara Rao Kanusu, Sivasankaran Venugopal, Naveen Rangarajan, Shivasankar Krishnamoorthy, Srinivas Reddy Dubbaka, Patrick O’Neill, Jie Wu
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Recent Highlights in Micellar Catalysis: An Industrial Outlook Org. Process Res. Dev. (IF 3.4) Pub Date : 2024-03-14 Tharique N. Ansari, Guolin Xu, Andrew Preston, Peng Gao
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An Intramolecular Diels–Alder Approach to the Isoindolinone Core of AZD8154 Org. Process Res. Dev. (IF 3.4) Pub Date : 2024-03-13 James J. Douglas, David Buttar, Katharine Locke, Andrew Turner
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Transition-Metal-Free Synthesis of a Densely Functionalized Benzodioxole Intermediate toward Lotiglipron Org. Process Res. Dev. (IF 3.4) Pub Date : 2024-03-12 Jimmy Wang, James Clarke, Matthew Badland, Brian Broadbelt, Louise F. Dow, Harriet A. M. Fenton, Daniel A. Laity, Jinu S. Mathew, Emily K. Rose, Neringa Tamosiunaite, Steven J. R. Twiddle, Robert Walton
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Continuous Flow Chemistry with Solids: A Review Org. Process Res. Dev. (IF 3.4) Pub Date : 2024-03-14 Hannah L. D. Hayes, Carl J. Mallia
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2,5-Dihydro-1H-pyrrol-3-yl Boronic Derivatives: Multigram Synthesis and Coupling Reactions Org. Process Res. Dev. (IF 3.4) Pub Date : 2024-03-13 Oleksandr S. Liashuk, Oleksandr P. Demchuk, Oleksandr V. Hryshchuk, Oleksandr O. Grygorenko
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High-Speed Circulation Flow Platform Facilitating Practical Large-Scale Heterogeneous Photocatalysis Org. Process Res. Dev. (IF 3.4) Pub Date : 2024-03-13 Chenguang Liu, Lei Song, Qiong Liu, Weihao Chen, Jinhui Xu, Mu Wang, Yanbin Zhang, Ting Wei Tan, Zhexuan Lei, Lei Cheng, Saif A. Khan, Jie Wu
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Highly Productive Flow Synthesis for Lithiation, Borylation, and/or Suzuki Coupling Reaction Org. Process Res. Dev. (IF 3.4) Pub Date : 2024-03-13 Hiroki Soutome, Kei Maekawa, Yosuke Ashikari, Aiichiro Nagaki
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Application of Twin Screw Extrusion to Scale Polymorphs, a Salt, and the Amorphous Phase for Various Drug Substances Org. Process Res. Dev. (IF 3.4) Pub Date : 2024-03-12 Henry Morrison, Peter Fung, Elizabeth Horstman, Olga Lapina, Thoeun Khuth, Diane S. Lye, Christopher S. Regens, Dustin Bringley, Jennifer Alleva
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Integrated Filtration and Washing Modeling: Optimization of Impurity Rejection for Filtration and Washing of Active Pharmaceutical Ingredients Org. Process Res. Dev. (IF 3.4) Pub Date : 2024-03-12 Bhavik A. Mehta, Ekaterina Gramadnikova, Cameron J. Brown, Niall A. Mitchell, Sara Ottoboni
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Process Development and Kinetic Analysis in the Green Synthesis of Lomustine Org. Process Res. Dev. (IF 3.4) Pub Date : 2024-03-11 Giulia Murbach-Oliveira, Ilke Akturk, Zoltan Nagy, David H. Thompson
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Rapid Multikilogram Scale-Up of Di- and Trifluoromethoxy Proline Derivatives Org. Process Res. Dev. (IF 3.4) Pub Date : 2024-03-11 Pablo J. Cabrera, Christophe Allais, Joel T. Arcari, María González-Esguevillas, Emma L. McInturff, Matthew R. Reese
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Development of a Directed Ketal Hydrogenation for the Synthesis of a Key Intermediate of Lanabecestat Org. Process Res. Dev. (IF 3.4) Pub Date : 2024-03-09 Rachel H. Munday
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Application of Immobilized Enzymes in Flow Biocatalysis for Efficient Synthesis Org. Process Res. Dev. (IF 3.4) Pub Date : 2024-03-08 Zhongyao Tang, Yuri Oku, Tomoko Matsuda
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Photochemistry in Pharmaceutical Development: A Survey of Strategies and Approaches to Industry-wide Implementation Org. Process Res. Dev. (IF 3.4) Pub Date : 2024-03-08 Eric G. Moschetta, Gemma C. Cook, Lee J. Edwards, Michael A. Ischay, Zhen Lei, Frederic Buono, François Lévesque, Jeffrey A. O. Garber, Maura MacTaggart, Melda Sezen-Edmonds, Kevin P. Cole, Matthew G. Beaver, Jaika Doerfler, Suzanne M. Opalka, Wenli Liang, Peter D. Morse, Naomi Miyake
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Manufacturing Process Development of Tegoprazan as a Potassium-Competitive Acid Blocker (P-CAB) Org. Process Res. Dev. (IF 3.4) Pub Date : 2024-03-08 Jae-Hong Kweon, Hyungjin Shin, Min Kyoung Lee, Sung Ah Lee, Pargat Singh, Kyeongwon Moon, In Su Kim
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Development of a Scalable Synthesis of a Drug-Linker for ABBV-3373 Org. Process Res. Dev. (IF 3.4) Pub Date : 2024-03-05 Nathan B. Bennett, Bradley D. Gates, Justin A. Simanis, James W. Treadway, Steven M. Richter, Dennie S. Welch
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Some Items of Interest to Process R&D Chemists and Engineers Org. Process Res. Dev. (IF 3.4) Pub Date : 2024-03-05 Alan Steven, Carlos Mateos, Andrei A. Zlota, Alexandre Barthelme, Paul F. Richardson, Robert B. Kargbo, Thomas Verheyen, John Knight
This article has not yet been cited by other publications.
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Integrating Functional Principal Component Analysis with Data-Rich Experimentation for Enhanced Drug Substance Development Org. Process Res. Dev. (IF 3.4) Pub Date : 2024-03-04 Jonathan P. McMullen, Brian M. Wyvratt, Cynthia M. Hong, Akasha K. Purohit
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A Scalable Solution to Constant-Potential Flow Electrochemistry Org. Process Res. Dev. (IF 3.4) Pub Date : 2024-03-01 Jeremy D. Griffin, Kaid C. Harper, Simon Velasquez Morales, Westin H. Morrill, William I. Thornton, David Sutherland, Bradley A. Greiner
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Continuous Production of an API Suspension (ZS-9) under Oscillatory Flow at Intensified Temperature and Pressure Org. Process Res. Dev. (IF 3.4) Pub Date : 2024-02-28 Brendon J. Doyle, Gordana Vrbanec, Christof Aellig, Eugen Marcelić, Sarah Filliger, Arturo Macchi, Dominique M. Roberge
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Flow Chemistry for Synthesis of 2-(C-Glycosyl)acetates from Pyranoses via Tandem Wittig and Michael Reactions Org. Process Res. Dev. (IF 3.4) Pub Date : 2024-02-27 Jack J. Bennett, Paul V. Murphy
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Green Solid-Phase Peptide Synthesis: Oxyma-Triggered Spectrophotometric Monitoring of Residual Piperidine Org. Process Res. Dev. (IF 3.4) Pub Date : 2024-02-28 So̷ren Lindbæk Broman, Martin Rosenberg, Felix Wojcik, Anders Holm Hansen, Peter Hammer Guldager Egelund, Joan Malmstro̷m, Daniel Sejer Pedersen
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Scalable Quasi-Divided Cell Operation Using Spinning Cylinder Electrode Technology: Multigram Electrochemical Synthesis of an Axitinib Intermediate Org. Process Res. Dev. (IF 3.4) Pub Date : 2024-02-28 Bhanwar K. Malviya, Eric C. Hansen, Caleb J. Kong, Joseph Imbrogno, Jenson Verghese, Steven M. Guinness, Chase A. Salazar, Jean-Nicolas Desrosiers, C. Oliver Kappe, David Cantillo
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Doing More with Less, On Time and In Full: An Intelligent Multiattribute Process Optimization Platform Org. Process Res. Dev. (IF 3.4) Pub Date : 2024-02-26 Reihaneh Soleimany, Wenyao Zhang, Jee Seong Kwak, Debasis Mallik, Michael G. Organ
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Development of a Cost-Efficient Process Toward a Key Synthetic Intermediate of the EZH2 Inhibitor PF-06821497 Org. Process Res. Dev. (IF 3.4) Pub Date : 2024-02-26 Christopher P. Ashcroft, Alexander M. Berne, Florian Blasberg, Kelly Catlin, Michael R. Collins, Doug J. Critcher, Jean-Nicolas Desrosiers, Adam Goetz, Cheryl Hayward, Ricky A. Jones, Michael J. Karmilowicz, Nandell Keene, Carlos A. Martinez, Sebastien Monfette, Sebastian David Pattavina, Hahdi H. Perfect, John A. Ragan, Blake Rauschenberger, Neal W. Sach, Gemma Scotney, Scott C. Sutton, Courtney Talicska
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Regulatory Highlights Org. Process Res. Dev. (IF 3.4) Pub Date : 2024-02-27 Andrew Teasdale, Stewart F. Owen
This article has not yet been cited by other publications.
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Automated Experimentation Enables a Data-Driven Model for Palladium Removal with Aqueous Chelators Org. Process Res. Dev. (IF 3.4) Pub Date : 2024-02-23 Sofio Kochiashvili, Yasser Jangjou, Christopher Nunn, Jun Yuh, Benjamin Harlee IV, Katherine M. P. Wheelhouse, Anna L. Dunn
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Dynamic Spinning Disc Reactor Technology to Enable In Situ Solid Product Formation in a Diazotization and Azo Coupling Sequence Org. Process Res. Dev. (IF 3.4) Pub Date : 2024-02-21 Dominik Polterauer, Kevin M. P. van Eeten, Wouter Stam, Christopher A. Hone, C. Oliver Kappe
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Green Chemistry Articles of Interest to the Pharmaceutical Industry Org. Process Res. Dev. (IF 3.4) Pub Date : 2024-02-22 Melissa A. Ashley, Miles H. Aukland, Marian C. Bryan, Megan A. Cismesia, Theresa Dutschei, Oliver D. Engl, Pascal S. Engl, Álvaro Enriquez Garcia, Alejandro Gimenez Molina, Vanessa Harawa, Christopher B. Kelly, Alexandre Leclair, Zhen Lei, Wei Li, Jan Pawlas, Samuel C. Scott, Alan Steven, Balaram S. Takale, Daniel S. Treitler, Hao Wu, Mingshuo Zeng, Yongda Zhang
This article has not yet been cited by other publications.
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Process Safety in the Pharmaceutical Industry─Part II: Process Safety Labs and Instruments Used in Process Safety Labs for Thermal Hazards Org. Process Res. Dev. (IF 3.4) Pub Date : 2024-02-22 Lady Mae Alabanza, Ayman Allian, Antonio C. Ferretti, Max Sarvestani, Jeffrey B. Sperry, Zhe Wang, Han Xia, Shasha Zhang
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Development of a Kilogram-Scale Chemical Process for a Chiral Spirocyclic Isoxazolone Org. Process Res. Dev. (IF 3.4) Pub Date : 2024-02-21 Yongda Zhang, Eugene Chong, Jada A. H. White, Suttipol Radomkit, Yibo Xu, Stephanie C. Kosnik, Qi Jiang, Jon C. Lorenz
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Continuous Flow Synthesis of a Key Intermediate Common to Gefitinib and Larotinib Org. Process Res. Dev. (IF 3.4) Pub Date : 2024-02-20 Han Zhang, Yifan Li, Xinyi Wu, Ning Wang, Xiaolin Chen, Yuxiang Jin, Fengli Dai, Chunnian Xia
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In Silico Prediction of Pharmaceutical Degradation Pathways: A Benchmarking Study Using the Software Program Zeneth Org. Process Res. Dev. (IF 3.4) Pub Date : 2024-02-19 Rachel Hemingway, Steven W. Baertschi, David Benstead, John M. Campbell, Maggie Coombs, Zongyun Huang, Ryan Khalaf, Martin A. Ott, David J. Ponting, Darren L. Reid, Neil G. Stevenson, Samuel J. Webb, Angela White, Todd Zelesky
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Enzyme Screening and Engineering for N- and O-Demethylation: Key Steps in the Synthesis of Buprenorphine Org. Process Res. Dev. (IF 3.4) Pub Date : 2024-02-16 Alexandra T. P. Carvalho, Daniel F. A. R. Dourado, Jenny Spratt, Jill M. Caswell, Timofey Skvortsov, Derek J. Quinn, John S. Carey, Thomas S. Moody
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Development of a Continuous Flow Process for the Efficient Preparation of Anti-Tuberculosis-Specific Drug TBAJ-876 Org. Process Res. Dev. (IF 3.4) Pub Date : 2024-02-14 Feng Gao, Jing Li, Guowei Zhang, Wenting Gu, Zhenfeng Zhang, Zhiqing Liu, Wanbin Zhang
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Stereoselective Construction of 3-(Aminoalkylidene)oxindoles in One Pot: Development of a Novel, Robust, and Scalable Process for the Multigram-Scale Preparation of Nintedanib Org. Process Res. Dev. (IF 3.4) Pub Date : 2024-02-15 Saroj Maji, Sabyasachi Halder, Ashok Kumar Sharma, Avinash Madhesiya, Tejender S. Thakur, Gautam Panda
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A Continuous Process for Manufacturing Apremilast. Part II: Process Characterization to Establish a Parametric Control Strategy Org. Process Res. Dev. (IF 3.4) Pub Date : 2024-02-13 Daniel J. Griffin, Hsiao-Wu Hsieh, Nadide Hazal Avci, Nandini Sarkar, James D. Fostinis, Nicholas Klitzing, James I. Murray, Rasangi Wimalasinghe, Simone Spada, Alicia Zeng, Matthew G. Beaver
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Development of a Novel Chemoenzymatic Process for 3-(Methylsulfonyl)-l-phenylalanine Phenylmethyl Ester─A Key Intermediate of Lifitegrast (Xiidra) Org. Process Res. Dev. (IF 3.4) Pub Date : 2024-02-14 Chuanjun Wu, Heng Guo, Jiawei Tang, Lintao Xia, Jianfen Shao, Yongfu He, Fei Chen, Peng Peng, Yuewen Han, Chuanmeng Zhao, Fuli Zhang, Shaoxin Chen
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Scalable Synthesis of C5aR1 Antagonist ACT-1014-6470 via N7-Selective Reductive Amination of an Unprotected Pyrazole Starting Material and Intramolecular Urea Formation with 1,1′-Carbonyl-di(1,2,4-triazol) (CDT) Org. Process Res. Dev. (IF 3.4) Pub Date : 2024-02-08 Stefan Reber, Nicole Blumer, Daniel Leuenberger, Tony Fleischer, Dorte Renneberg, Stefan Abele, Gabriel Schäfer
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Development of an Early Phase Process for a Potent Oligodendrocyte Precursor Cell Differentiator Org. Process Res. Dev. (IF 3.4) Pub Date : 2024-02-09 Donald G. Walker, Steven Ferguson, Michael J. Humora, Erwin Irdam, William F. Kiesman, Daw-Iong Albert Kwok, Wenli Liang, Suzanne M. Opalka
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Continuous Flow Synthesis of 5-Methyltetrahydrofolate from Folic Acid Org. Process Res. Dev. (IF 3.4) Pub Date : 2024-02-09 Yu Zhang, Minghui Xiao, Ranran Feng, Hong-Yu Zhang, Yuecheng Zhang, Jiquan Zhao
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Generative PAT Fingerprint Approach for Verification of the Scale-Up of Pharmaceutical Processes Org. Process Res. Dev. (IF 3.4) Pub Date : 2024-02-11 Jan Dijkmans, Joris Chau, Tor Maes, Tatsiana Khamiakova, Stijn Laps, Niels Vandervoort
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Practical and Scalable Synthesis of 1,3-Adamantanediol Org. Process Res. Dev. (IF 3.4) Pub Date : 2024-02-08 Fuhao Hao, Rener Chen, Zuoguo Yang, Jianhua Chen, Zhongjia Bai, Jing Xu, Zhongbao Yu, Buawa Maimaiti, Wanqin Guo, Hao Feng
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Process Development of a Novel Route to Rilpivirine Hydrochloride Org. Process Res. Dev. (IF 3.4) Pub Date : 2024-02-08 Kenny Delacroix, Baptiste Fours, Solenne Kowalkowski, Vincent Revil-Baudard, Marc Perez, Laurent Petit
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Some Items of Interest to Process R&D Chemists and Engineers Org. Process Res. Dev. (IF 3.4) Pub Date : 2024-02-07 James A. Schwindeman, Alex Kosanovich, Christopher B. Kelly, Timothy Kwok, Hannah L. D. Hayes, Annabel Q. Ansel, James M MacDougall, Sylvain Guizzetti, John Knight
This article has not yet been cited by other publications.
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Early Process Development and Scale-Up of a Positive Allosteric Modulator of the α7 Nicotinic Acetylcholine Receptor Org. Process Res. Dev. (IF 3.4) Pub Date : 2024-02-07 Takayoshi Tajima, Go Ito, Aki Saito, Yoshinori Kohmura
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Evolution of a Green and Sustainable Manufacturing Process for Belzutifan: Part 5─Chemoenzymatic Diastereoselective Fluorination/DKR Org. Process Res. Dev. (IF 3.4) Pub Date : 2024-02-07 Scott D. McCann, Sean H. Dubina, Birgit Kosjek, Embarek Alwedi, Taylor Behre, Samantha A. Burgess, Guilherme Dal Poggetto, Daniel A. DiRocco, Clara Hartmanshenn, Jonathan P. McMullen, Nilusha Padivitage, Alexandra C. Sun
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Development and Scale-Up of a New Sulfone-Based Bismacycle as a Universal Precursor for Bi(V)-Mediated Electrophilic Arylation Org. Process Res. Dev. (IF 3.4) Pub Date : 2024-02-07 Andrew Fox, Liam T. Ball
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Correction to “Some Items of Interest to Process R&D Chemists and Engineers” Org. Process Res. Dev. (IF 3.4) Pub Date : 2024-02-06 Alan Steven, Carlos Mateos, Andrei A. Zlota, Christopher C. Nawrat, Alexandre Barthelme, Paul F. Richardson, Robert B. Kargbo, John Knight
In the January 2024 edition of the Items of Interest to Process R&D Chemists and Engineers, in the item Bismuth-Catalyzed Trifluoromethylation of C(sp2)–H Bonds under Light (Cornella, J.; et al. J. Am. Chem. Soc., DOI: 10.1021/jacs.3c10333), the structure for the bismuth catalyst was incorrect; the correct structure is presented below. This article has not yet been cited by other publications.
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Large-Scale Synthesis of LPA1-Receptor Antagonist ACT-1016-0707 Org. Process Res. Dev. (IF 3.4) Pub Date : 2024-02-05 Raffael Davenport, Florence Masse, Alice Prud’homme, Cédric Bürki, Patric Doerrwaechter, Marco Künzli, Fabio D’Aiuto, Martin H. Bolli, Gabriel Schäfer
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Evolution of a Green and Sustainable Manufacturing Process for Belzutifan: Part 1─Process History and Development Strategy Org. Process Res. Dev. (IF 3.4) Pub Date : 2024-02-05 Daniel A. DiRocco, Yong-Li Zhong, Diane N. Le, Scott D. McCann, J. Caleb Hethcox, Jungchul Kim, Joshua N. Kolev, Birgit Kosjek, Stephen M. Dalby, Jonathan P. McMullen, Rekha Gangam, William J. Morris
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Evolution of a Green and Sustainable Manufacturing Process for Belzutifan: Part 6─Development of a Nucleophilic Aromatic Substitution in Water Org. Process Res. Dev. (IF 3.4) Pub Date : 2024-02-05 Diane N. Le, Timothy J. Wright, Embarek Alwedi, Clara Hartmanshenn, Hong Li, Jonathan P. McMullen, Daniel A. DiRocco
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Development of a Thiophosphorylation Process for the Synthesis of 2′F-Thio-Adenosine Monophosphate Org. Process Res. Dev. (IF 3.4) Pub Date : 2024-02-05 Jennifer V. Obligacion, Tao Wang, Thomas T. Kwok, Daniel Zewge, Ryan D. Cohen, Mikhail Reibarkh, Artis Klapars, Kerstin Zawatzky, Stephanus Axnanda, Zhu Liu, Zachary E. X. Dance, Joseph P. Smith, Wendy Zhong, Heather Wang, Cheol K. Chung, Nastaran Salehi Marzijarani, Zhijian Liu
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A Continuous Process for Manufacturing Apremilast. Part I: Process Development and Intensification by Utilizing Flow Chemistry Principles Org. Process Res. Dev. (IF 3.4) Pub Date : 2024-02-02 Hsiao-Wu Hsieh, Carolyn M. Cohen, Daniel J. Griffin, Padmini Ananthoji, Nadide Hazal Avci, Derek B. Brown, Ari Ericson, James D. Fostinis, Muhammad Irfan, Neil Langille, Michael A. Lovette, James I. Murray, Simone Spada, Oliver R. Thiel, Frankie Aiello, Joseph Daou, Nicole Goudas-Salomon, Ende Pan, Nandini Sarkar, Rasangi Wimalasinghe, Zufan Steven Wu, Alicia Zeng, Matthew G. Beaver
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Evolution of a Green and Sustainable Manufacturing Process for Belzutifan: Part 3─Development of a Scalable Enzymatic Oxidation Process Org. Process Res. Dev. (IF 3.4) Pub Date : 2024-02-01 Jungchul Kim, Victoria Zhang, Kotoe Abe, Yangzhong Qin, Daniel A. DiRocco, Jonathan P. McMullen, Alexandra Sun, Rekha Gangam, Matthew Chow, Anthony Pitts-McCoy, Arnav Sunil Malkani
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Evolution of a Green and Sustainable Manufacturing Process for Belzutifan: Part 4─Applications of Process Analytical Technology in Heterogeneous Biocatalytic Hydroxylation Org. Process Res. Dev. (IF 3.4) Pub Date : 2024-02-01 Yangzhong Qin, Keith A. Mattern, Victoria Zhang, Kotoe Abe, Jungchul Kim, Michelle Zheng, Rekha Gangam, Alexei Kalinin, Joshua N. Kolev, Stephanus Axnanda, Zachary E. X. Dance, Umme Ayesa, Yining Ji, Shane T. Grosser, Emmanuel Appiah-Amponsah, Jonathan P. McMullen
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Development of a Sustainable Chemoenzymatic Process for (S)-Pregabalin Synthesis via Nitrilase-Catalyzed Hydrolysis and Continuous Flow Racemization Org. Process Res. Dev. (IF 3.4) Pub Date : 2024-01-31 Chao-Ping Lin, Chen-Hui Xu, Fan-Yu Meng, Shi-Ping Song, Zhe-Ming Wu, Ren-Chao Zheng, Yu-Guo Zheng