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Improved Synthetic Process of Baloxavir Marboxil Intermediate 3-Benzyloxy-4-oxo-4H-pyran-2-carboxylic Acid Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-06-02 Kongcheng Huang, Jianwu Lu, Xiaoxu Wang, Yinfei Shi, Kaimike Yang, Shun Yuan, Yinquan Wang, Han Sun, Yuebin Liu, Xun Sun, Taizhi Wu
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Thermal Behavior and Decomposition Pathway for Nitrophenols and Sodium Nitrophenolates Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-06-02 Shichun Weng, Wei Feng, Wenqian Wu, Zichao Guo, Liping Chen, Wanghua Chen
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Coaxial Dielectric Spectroscopy as an In-Line Process Analytical Technique for Reaction Monitoring Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-05-30 Desiree M. Dalligos, Michael J. Pilling, Georgios Dimitrakis, Liam T. Ball
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Approaches and Considerations for the Investigation and Synthesis of N-Nitrosamine Drug Substance-Related Impurities (NDSRIs) Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-05-30 Ian W. Ashworth, Alexander Blanazs, Jonathan J. Byrne, Olivier Dirat, Jared W. Fennell, Nadine Kuhl, Stuart L. Wells, Matthew P. Whiting
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Precise Control of the Oxidation Reaction in a High-Purity Dexlansoprazole Synthesis Process Using In Situ Infrared Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-05-27 Chunchao Wang, Haoyu Wang, Cheng Huang, Chengjun Wu, Tiemin Sun
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Scalable Synthesis of the Shelf-Stable Radical Difluoromethylthiolation Reagent S-(Difluoromethyl)benzenesulfonothioate PhSO2SCF2H Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-05-24 Xin Qiu, Wenrun Lou, Shengxue Zhang, Shengyajun Meng, Yong Guo, Xiaoyu Ma, Chao Liu, Qilong Shen
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Process Development and Scale-Up of the SOS1 Inhibitor MRTX0902 Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-05-22 Thomas Scattolin, Joseph R. Lizza, Zhiliang Xu, Dan Zhao, Cheng-yi Chen
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New Bench-Scale Method To Elucidate Active Pharmaceutical Ingredient Drying Mechanisms Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-05-19 David J. Lamberto, Eric Sirota, George Zhou
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Practical Synthesis of Tenofovir Alafenamide Fumarate Inspired by New Retrosynthetic Disconnection Featuring a Novel Carbon–Phosphorus Bond Construction Methodology Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-05-19 Xiuping Liu, Chen Chen, Muzi Li, Man Li, Jie Ren, Qingwen Zhang
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Effect of Nitrogen, Air, and Oxygen on the Kinetic Stability of NAD(P)H Oxidase Exposed to a Gas–Liquid Interface Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-05-19 Jingyu Wang, Elif Erdem, John M. Woodley
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First-Generation Process Development of Napabucasin and Impurity Control Strategy Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-05-12 Christopher E. Katz, Bingidimi I. Mobele, Jalal Haddad, Yusuke Yamai, Kazuki Hashimoto, Yujiro Kiyoshima, Justin Caserta
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Scalable Electrochemical Reduction of Nitrobenzotrifluorides to 3-Trifluoromethylanilines Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-05-12 Camila M. Kisukuri, Johannes Seidler, Tobias Gärtner, Denis F. Rohrmann, Siegfried R. Waldvogel
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Scalable Atroposelective Synthesis of MRTX1719: An Inhibitor of the PRMT5/MTA Complex Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-05-10 Michal Achmatowicz, Thomas Scattolin, David R. Snead, Dinesh J. Paymode, Sahar Roshandel, Chen Xie, Guihui Chen, Cheng-yi Chen
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Some Items of Interest to Process R&D Chemists and Engineers Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-05-10 Alan Steven, Carlos Mateos, Andrei A. Zlota, Christopher C. Nawrat, Alexandre Barthelme, Rik Oost, Paul F. Richardson, Robert B. Kargbo, John Knight
This article has not yet been cited by other publications.
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Mass Transport of Diazomethane across Teflon AF2400 Membrane for Scale-Up Development Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-05-08 Filip Horvath-Gerber, King Kuok (Mimi) Hii, Christian Holtze, Eleonore Jeanne Camille Deublein, Klaus Hellgardt
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Continuous Flow Synthesis of Esomeprazole via Asymmetric Sulfoxidation Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-05-04 Tianxiang Gao, Jingnan Zhao, Huinan Sun, Jianing Li, Cunfei Ma, Qingwei Meng
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Route Optimization of the Noncovalent Modulator of Hemoglobin PF-07059013 for Treatment of Sickle Cell Disease through a Palladium-Mediated C–O Coupling, Part II: Pilot Plant Scale Manufacture Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-05-04 Cameron Abercrombie, Christopher P. Ashcroft, Matthew Badland, Aaron Baldwin, Livia T. Baldwin, Sarah Brisley, Wayne Callar, Pedro Daddario, Elaa Hilou, Chintelle James, Ruizhi Li, Yiyang Liu, Sebastien Monfette, Jared L. Piper, Giselle Reyes, Hud Risley, Fabrice H. Salingue, Kudzai Saunyama, Michael G. Vetelino
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Efficient and Scalable Synthesis of Ketoprofen: A Pyrolytic Aromatization Approach Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-05-04 Lili Song, Zhigang Liu, Minjie Liu, Pei Tang, Fener Chen
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Assessment of Sulfur Impurities in GMP-Grade Diisopropylcarbodiimide and Their Impact on Coupling Reagent-Induced Side Reactions in Peptide Synthesis Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-05-04 Jan Pawlas, Jon H. Rasmussen
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How to Develop Organometallic Catalytic Reactions in the Pharmaceutical Industry Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-05-03 Vittorio Farina
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Short and Scalable Synthesis of Enantiopure N-Boc-trans-4-methyl-L-prolinol Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-05-03 Jaydeo T. Kilbile, Yasinalli Tamboli, Jagdish D. Shukla, Arvind Y. Merwade
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API Syntheses in Aqueous Media: Assessing the Environmental Footprint en route from Academic Discovery to Industrial Applications as “Green Opportunity” for Process Chemistry Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-05-01 Nico Fleck, Frank Roschangar, Alexander M. Haydl
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Ruthenium-Catalyzed Direct Asymmetric Reductive Amination for the Synthesis of a Chiral Primary Amine Intermediate En Route to a PDE2A Inhibitor, TAK-915 Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-04-27 Masatoshi Yamada, Koichi Murai, Kotaro Yamaguchi, Mitsuhisa Yamano
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Development of Versatile Routes for the Preparation of an Intermediate to Immuno-Oncology Agonist BMS-986299 Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-04-26 Dengke Li
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Aqueous Electrochemical Synthesis of 5-Trifluoromethyluracil in Batch and Continuous Flow Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-04-21 Ruoqu Gong, Yicheng Zhou, Dandan Sui, Yang Chen, Wenbo Chen
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A Consideration of the Extent That Tertiary Amines Can Form N-Nitroso Dialkylamines in Pharmaceutical Products Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-04-19 Ian W. Ashworth, Timothy Curran, Olivier Dirat, Jinjian Zheng, Matthew Whiting, Daniel Lee
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Synthetic Approaches to a Key Pyridone-carboxylic Acid Precursor Common to the HIV-1 Integrase Strand Transfer Inhibitors Dolutegravir, Bictegravir, and Cabotegravir Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-04-20 Pankaj S. Mahajan, Terrence R. Burke, Jr.
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Development of a Concise Process for the Synthesis of the Azaindazole Core of the CD73 Inhibitor AB680 Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-04-19 Xiaopeng Yin, Zhiguo Jake Song, Jaroslaw Kalisiak, Jonathan C. Tripp, Xiao Lei, Hongfeng Li, Aimin Zhang
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Utilization of Quality by Design, Kinetic Modeling, and Computational Fluid Dynamics for Process Optimization and Scale-Up Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-04-17 Venkata Ramana Kandula, Latif Shaikh, Gautam Samanta
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Development of a Scalable Route toward an Alkylated 1,2,4-Triazol, a Key Starting Material for CXCR3 Antagonist ACT-777991 Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-04-14 Raffael Davenport, Alice Prud’homme, Florence Masse, Gabriel Schäfer
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Multigram, Chromatography-Free Synthesis of the Flavonol Morin Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-04-13 Grigor Gurzadyan, Steffen Mende, Alexander Schmid, Thomas Lindel
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Temperature-Controlled Photoreactors and ChemBeads as Key Technologies for Robust and Practical Photochemical HTE Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-04-13 Paolo Piacentini, James M. Fordham, Eloisa Serrano, Luca Hepp, Marco Santagostino
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Some Items of Interest to Process R&D Chemists and Engineers Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-04-13 James A. Schwindeman, David S. B. Daniels, James J. Douglas, Alex Kosanovich, Wenyi Zhao, Christopher B. Kelly, Timothy Kwok, Sylvain Guizzetti, John Knight
This article has not yet been cited by other publications.
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Process Development for the Synthesis of BI 1702135: A Concise Design Enabled by Selective Acylation of a 2-Aminobenzimidazole Intermediate Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-04-05 Jiang-Ping Wu, Wei-Tong Dong, Chengsheng Chen, Alexander Sienkiewicz, Phouvieng Beyer, Jun Wang, Nizar Haddad, Jon C. Lorenz, Jonathan T. Reeves, Matthew H. Bunner, Nina C. Gonnella, Harald Weinstabl, Géraldine Garavel
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Leveraging Prior Knowledge to Support Early Phase Clinical Trial Applications: Regulatory CMC Considerations and Case Studies Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-04-04 Sofie Fogh Hedegaard, Rosa Rebecca Erritzøe Hansen, Robert Nelson, Niels Kristian Klausen, Christian Fogt Hjorth, Lori Troup, Marie Eskling, Morten Storgaard, Saad Khürshid, Scott W. Roberts
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Green Chemistry Articles of Interest to the Pharmaceutical Industry Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-04-04 Marian C. Bryan, Charlotte Dalton, Alba Díaz-Rodríguez, Jaika Doerfler, Oliver D. Engl, Alejandro Gimenez Molina, Vanessa Harawa, Christopher B. Kelly, Wei Li, Rachel H. Munday, Jan Pawlas, Paul F. Richardson, William J. Smith, III, Alan Steven, Balaram S. Takale, Jack A. Terrett, Daniel S. Treitler, Mingshuo Zeng
This article has not yet been cited by other publications.
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Toward the Development of a Manufacturing Process for Milvexian: Scale-Up Synthesis of the Side Chain Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-04-03 Simon Wagschal, Diego Broggini, Trung D.C. Cao, Pascal Schleiss, Kristian Paun, Jessica Steiner, Anna-Lena Merk, Joachim Harsdorf, Winfried Fiedler, Stefan Schirling, Sven Hock, Tobias Strittmatter, Jan Dijkmans, Ivan Vervest, Tim Van Hoegaerden, Brecht Egle, Matthew P. Mower, Zhi Liu, Zhiyong Cao, Xiaoning He, Lei Chen, Lei Qin, Hongyu Tan, Jun Yan, Nicolas Lucien Cunière, Carolyn S. Wei, Venkata
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Advanced In-Line Purification Technologies in Multistep Continuous Flow Pharmaceutical Synthesis Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-03-30 Zhexuan Lei, Hwee Ting Ang, Jie Wu
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A Review of Tangential Flow Filtration: Process Development and Applications in the Pharmaceutical Industry Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-03-31 Paridhi Agrawal, Katerina Wilkstein, Emily Guinn, McKensie Mason, Carolina I. Serrano Martinez, Jeremiah Saylae
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Development of the Methodology for in Silico Reactivity-Based Purge Predictions: Making Mirabilis Think Like a Chemist Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-03-29 James A. McManus, Rocío Lopez-Rodríguez, Natasha S. Murphy, Lara James, Daniel C. O’Connor, Georgina C. Gavins, Michael J. Burns
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A Novel and Practical Synthesis of 5-Fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carbonitrile, a Key Intermediate of Vericiguat Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-03-30 Siju Bi, Wenshuang Diao, Ting Tian, Ting Zhou, Kuaile Lin, Weicheng Zhou
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Optimized Synthesis of Indole Carboxylate Metallo-β-Lactamase Inhibitor EBL-3183 Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-03-30 Andrei Baran, Jevgenijs Kuzmins, Jevgenijs Kuznecovs, Alistair J. M. Farley, Tharindi Panduwawala, Anete Parkova, Pavel A. Donets, Jürgen Brem, Edgars Suna, Christopher J. Schofield, Kirill Shubin
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Continuous Flow-Facilitated CB2 Agonist Synthesis, Part 1: Azidation and [3 + 2] Cycloaddition Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-03-30 Peter Sagmeister, Michael Prieschl, Dainis Kaldre, Chethana Gadiyar, Christian Moessner, Joerg Sedelmeier, Jason D. Williams, C. Oliver Kappe
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Toward a Combined Molecular Dynamics and Quantum Mechanical Approach to Understanding Solvent Effects on Chemical Processes in the Pharmaceutical Industry: The Case of a Lewis Acid-Mediated SNAr Reaction Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-03-29 Gerald J. Tanoury, Satish Kumar Iyemperumal, Elaine C. Lee
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Continuous Flow-Facilitated CB2 Agonist Synthesis, Part 2: Cyclization, Chlorination, and Amination Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-03-29 Michael Prieschl, Peter Sagmeister, Christian Moessner, Joerg Sedelmeier, Jason D. Williams, C. Oliver Kappe
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Scalable, Green Synthesis of Heteroaromatic Amine-boranes Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-03-28 P. Veeraraghavan Ramachandran, Henry J. Hamann, Randy Lin, Aman Singh
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Photocatalytic and Photoinduced Phosphonylation of Aryl Iodides: A Batch and Flow Study Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-03-24 Romain Lapierre, Thi Minh Thi Le, Bruno Schiavi, Damien Thevenet, Marc Bazin, Ryan Buzdygon, Philippe Jubault, Thomas Poisson
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Prevalence of Impurity Retention Mechanisms in Pharmaceutical Crystallizations Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-03-24 Fredrik L. Nordstrom, Eric Sirota, Clara Hartmanshenn, Thomas T. Kwok, Mitchell Paolello, Huayu Li, Vincent Abeyta, Tommasina Bramante, Emma Madrigal, Taylor Behre, Gerard Capellades
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Case Studies in the Application of a Workflow-Based Crystallization Design for Optimized Impurity Rejection in Pharmaceutical Development Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-03-24 Paridhi Agrawal, Saurin H. Rawal, Venkata Ramana Reddy, Shekhar K. Viswanath, Jeremy M. Merritt
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Alternative Approach to the Large-Scale Synthesis of the Densely Functionalized Pyrrolidone BMT-415200 Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-03-22 Souvik Rakshit, Shunmugaraj Sathasivam, Raghurami Reddy, Saladi V. Rao, Vijaykumar Shekarappa, Moorthy Kandasamy, Mohamed Jaleel, Saravanan Murugan, Anuradha Bhat, Tamilarasan Subramani, Thirumalai Lakshminarasimhan, Aravind Gangu, Steven R. Wisniewski, Nathaniel Kopp, Ian Hale, Jason M. Stevens, Victor W. Rosso, Martin D. Eastgate, Rajappa Vaidyanathan
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Collaboration as a Key to Advance Capabilities for Earth-Abundant Metal Catalysis Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-03-20 Paul J. Chirik, Keary M. Engle, Eric M. Simmons, Steven R. Wisniewski
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Integrating Process Development and Safety Analysis for Scale-Up of a Diborane-Generating Reduction Reaction Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-03-21 Brittany M. Armstrong, Taylor Behre, Ben W. H. Turnbull, Daniel Bishara, Clara Hartmanshenn, Erin McCarthy, Michael Whittington, Yining Ji, Anna Jenks, Richard Desmond, Daniel J. Muzzio, James Corry, Ralph Zhao, Nadine Kuhl, Cheol K. Chung
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Rapid Enantiomeric Excess Measurements of Enantioisotopomers by Molecular Rotational Resonance Spectroscopy Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-03-17 Reilly E. Sonstrom, Zoua Pa Vang, Haley N. Scolati, Justin L. Neill, Brooks H. Pate, Joseph R. Clark
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Spherical Agglomeration of Safinamide Mesylate: A Case Study of a Simultaneous Control of Crystalline Landscape and Micromeritic Properties Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-03-17 Aurélien Lemercier, Yohann Cartigny, Pierrick Morice, Elise Vanbiervliet, Massimiliano Forcato, Gérard Coquerel
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Biocatalytic Asymmetric Reduction of a Sterically Hindered α-Bromo Ketone for the Synthesis of Key Intermediates of Olodaterol Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-03-15 Yahui Feng, Zihong Zhou, Shuming Wu, Wei Lin, Songquan Lu, Xiaolei Pang, Ke Xia, Fang He, Qin Zhang, Hu Yang, Zhongqing Wang
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Scalable Palladium-Catalyzed C(sp3)–H Carbonylation of Alkylamines in Batch and Continuous Flow Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-03-15 Jacek Zakrzewski, Polina Yaseneva, Connor J. Taylor, Matthew J. Gaunt, Alexei A. Lapkin
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Establishing Best Practice for the Application and Support of Solubility Purge Factors Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-03-14 Michael J. Burns, Ian X. Andrews, Jens-Christoph Baumann, Eric L. Elliott, Jared W. Fennell, Jeffrey M. Kallemeyn, Sebastien Lemaire, Natasha S. Murphy, Magali Palacio, Steven A. Raw, Alastair J. Roberts, Nayrton Flávio Moura Rocha, Didier Schils, Rolf Schulte Oestrich, Andrew L. Shannon-Little, Neil Stevenson, Pere Talavera, Andrew Teasdale, Michael W. Urquhart, Fernanda Waechter
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Drawing a Line: Where Might the Cohort of Concern End? Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-03-14 David J. Ponting, Robert S. Foster
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Determining Phase Separation Dynamics with an Automated Image Processing Algorithm Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-03-14 James Daglish, A. John Blacker, Gregory de Boer, Alex Crampton, David R. J. Hose, Anna R. Parsons, Nikil Kapur
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Leveraging Synergistic Solubility in the Development of a Direct Isolation Process for Nemtabrutinib Org. Process Res. Dev. (IF 3.858) Pub Date : 2023-03-09 Yonggang Chen, Luca Iuzzolino, Samantha A. Burgess, Cheol K. Chung, James Corry, Morgan Crawford, Richard Desmond, Erik Guetschow, Clara Hartmanshenn, Nadine Kuhl, Zhu Liu, Hanlin Luo, Alison C. McQuilken, Justin A. Newman, Hong Ren, David A. Thaisrivongs, Zhixun Wang, Eric Sirota
更新日期：2023-05-22
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