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Scintillators with aggregation-induced emission Chem (IF 19.1) Pub Date : 2025-04-18 Sheng-Yi Yang, Liang Zhang, Fan-Cheng Kong, Yingying Chen, Wei-Jian Li, Fei Wang, Cheng Liu, Xuan He, Xuedong Xiao, Jin Wang, Jianwei Sun, Philip C.Y. Chow, Ryan T.K. Kwok, Jacky W.Y. Lam, Ben Zhong Tang
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Polar π stacking for metal-free near, remote, and ultra-remote C–H coupling with aryliodanes Chem (IF 19.1) Pub Date : 2025-04-18 Jorge D. Martín-Bernardos, Katrin Golob, Wei W. Chen, Orsola A. Luongo, Inés Sedó, Ana B. Cuenca, Alexandr Shafir
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A Sm(II)-based catalyst for the reduction of dinitrogen, nitrite, and nitrate to ammonia or urea Chem (IF 19.1) Pub Date : 2025-04-18 Rohan Bhimpuria, Rima Charaf, Ke Ye, Anders Thapper, Harsha Sathyan, Mårten Ahlquist, Leif Hammarström, K. Eszter Borbas
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Biosynthesis of nitrile-containing amino acids for rapid protein conjugation and fluorogenic labeling Chem (IF 19.1) Pub Date : 2025-04-17 Yu Hu, Mengxi Zhang, Han Xiao
The biosynthesis of bioorthogonal chemical handles for precise protein labeling remains a significant challenge. In this issue of Chem, Thomas Huber and colleagues report the successful biosynthesis of nitrile-containing amino acids and their site-specific incorporation into proteins, enabling efficient protein conjugation and fluorogenic labeling.
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A new breakthrough in ethanol reforming for zero-carbon hydrogen production Chem (IF 19.1) Pub Date : 2025-04-17 Ying Sun, Chang Yu, Jieshan Qiu
In Science, Ma and co-workers report a zero-CO2-emission reaction strategy involving the thermal catalytic ethanol reforming over a 3Pt3Ir/α-MoC catalyst to realize an unprecedented hydrogen production rate of 331.3 mmol H2 gcat−1 h−1 with 84.5% selectivity for value-added acetic acid at a low temperature of 270°C. This breakthrough could become a milestone in sustainable energy technologies and beyond
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Interfacial water regulation for water-participating electrocatalytic hydrogenation reactions Chem (IF 19.1) Pub Date : 2025-04-17 Yanmei Huang, Ying Gao, Bin Zhang
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Challenges and perspectives for the perovskite module research Chem (IF 19.1) Pub Date : 2025-04-16 Runda Li, Libing Yao, Jingyi Sun, Zengyi Sun, Kai Zhang, Jingjing Xue, Rui Wang
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Practical flow battery diagnostics enabled by chemically mediated monitoring Chem (IF 19.1) Pub Date : 2025-04-16 Mark E. Carrington, Loh Min Yi, Erlendur Jónsson, Clare P. Grey
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One-dimensional lead halide perovskite quantum ribbons with controllable edge terminations and ribbon widths Chem (IF 19.1) Pub Date : 2025-04-15 Xiaofan Jiang, Mingyuan Li, Yu Tao, Meng Zhang, Xinyu Li, Tianhao Zhang, Jiazhen Gu, Guangsheng Bai, Nanlong Zheng, Xuan Zhao, Huilong Hong, Leyang Jin, Xu Huang, Sanli Xu, Yan Guan, Chen Li, Wenkai Zhang, Yongping Fu
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Atomic-resolution imaging as a mechanistic tool for studying single-site heterogeneous catalysis Chem (IF 19.1) Pub Date : 2025-04-11 Yosi Kratish, Yiqi Liu, Jiaqi Li, Anusheela Das, Leighton O. Jones, Amol Agarwal, Qing Ma, Michael J. Bedzyk, George C. Schatz, Takayuki Nakamuro, Eiichi Nakamura, Tobin J. Marks
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Circumventing the activity-selectivity trade-off: Pt-Fe-Pt active sites for selective heterogeneous hydrogenation of crotonaldehyde Chem (IF 19.1) Pub Date : 2025-04-11 Hongchen Yang, Xiangwen Liu, Dingsheng Wang
In heterogeneous hydrogenation catalytic reactions, it is challenging to only hydrogenate the target functional group while preserving all other unsaturated bonds. In this issue of Chem, Shen and coworkers reported a Pt-Fe-Pt heterotrimer with densely populated and precisely arranged Pt atoms, which achieved an increased reaction rate and preferential hydrogenation of the C═O bond in crotonaldehyde
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Gold metallacages: Design principles and applications Chem (IF 19.1) Pub Date : 2025-04-10 Sophie R. Thomas, Nina Willnhammer, Angela Casini, Guillermo Moreno-Alcántar
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Emerging trends in CO carbonylation Chem (IF 19.1) Pub Date : 2025-04-10 Chang-Sheng Kuai, Yang Yuan, Xiao-Feng Wu
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In this issue Chem (IF 19.1) Pub Date : 2025-04-10
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Chimeric cofactors enable methyltransferase-catalyzed prenylation Chem (IF 19.1) Pub Date : 2025-04-09 Nicolas V. Cornelissen, Arne Hoffmann, Pulak Ghosh, Yanis L. Pignot, Mehmet Erguven, Andrea Rentmeister
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Rapid access to 3-substituted bicyclo[1.1.1]pentanes Chem (IF 19.1) Pub Date : 2025-04-08 Katherine I. Burton, David W.C. MacMillan
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Molecule-resolvable SERSome for metabolic profiling Chem (IF 19.1) Pub Date : 2025-04-04 Xinyuan Bi, Xiaohang Qian, Bingsen Xue, Miao Zhang, Shuyu Liu, Haoran Chen, Cheng Jin, Huidong Tang, Jian Ye
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Rapid generation of hypervariable chemical libraries Chem (IF 19.1) Pub Date : 2025-04-04 John S. Albin, Gha Young Lee, Corey Johnson, Dimuthu A. Vithanage, Wayne Vuong, Bradley L. Pentelute
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Functional liquid layer enabled superior performance of air purification filter Chem (IF 19.1) Pub Date : 2025-04-04 Qifei Wang, Yuheng Sheng, Xiaowei Song, Yuchen Qiu, Xiao Li, Chao Shang, Yang Wang, Jihong Yu
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Stable and responsive atropisomerism around a carbon–iodine bond Chem (IF 19.1) Pub Date : 2025-04-04 Shohei Abe, Jun Kikuchi, Arimasa Matsumoto, Naohiko Yoshikai
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Live bacterial chemistry in biomedicine Chem (IF 19.1) Pub Date : 2025-04-04 Senfeng Zhao, Qian Chen, Qimanguli Saiding, Soohwan An, Zhuoming Zhou, Na Kong, Yujing J. Heng, Reza Abdi, Wei Tao
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Recent advances in membrane and sorbent design for blood purification in sepsis and septic shock Chem (IF 19.1) Pub Date : 2025-04-03 Xin Ding, Xiang Zhou, Bin Du
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A programmable modular robot for the synthesis of molecular machines Chem (IF 19.1) Pub Date : 2025-03-31 Robert Rauschen, Jean-François Ayme, Bartosz M. Matysiak, Dean Thomas, Leroy Cronin
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Conventional versus singlet-triplet Kondo effect in Blatter radical molecular junctions: Zero-bias anomalies and magnetoresistance Chem (IF 19.1) Pub Date : 2025-03-27 Gautam Mitra, Jueting Zheng, Karen Schaefer, Michael Deffner, Jonathan Z. Low, Luis M. Campos, Carmen Herrmann, Theo A. Costi, Elke Scheer
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Chlorine-free synthesis of axially chiral organophosphorus compounds from white phosphorus Chem (IF 19.1) Pub Date : 2025-03-27 Xinlei Huangfu, Wei Liu, Zhiyi Song, Junnian Wei, Wen-Xiong Zhang
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Flipping the script: Predicting chemical composition in metal-halide perovskites from optical spectroscopy Chem (IF 19.1) Pub Date : 2025-03-27 Alexander J. Norquist
In this issue of Chem, Harel and co-workers report a chemical-space-property descriptor model capable of predicting chemical compositions of metal halide perovskites by using fast optical analyses. This model is designed to enable facile monitoring of chemical composition and assessment of material properties in industrial-scale syntheses.
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Precisely constructing asymmetric triple atoms for highly efficient electrocatalysis Chem (IF 19.1) Pub Date : 2025-03-26 Jingyan Zhang, Zhongxin Song, Xiaozhang Yao, Yi Guan, Ziwei Huo, Ning Chen, Lei Zhang, Xueliang Sun
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Alkane recognition enhanced by solvophobic interactions enables site-selective aliphatic C–H oxidation Chem (IF 19.1) Pub Date : 2025-03-26 Marco Galeotti, Laia Vicens, Miquel Costas
Site-selective C–H oxidation in substrates devoid of functional groups is a standing chemical problem. In the March issue of Chem, Tiefenbacher and co-workers combine solvophobic interactions and substrate recognition via dispersion interactions between a supramolecular catalyst and methyl groups of the substrate to implement unprecedented selectivity control in aliphatic C–H oxidation.
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Depolymerizing off-the-shelf polymethacrylates with visible light Chem (IF 19.1) Pub Date : 2025-03-26 Nicholas Ballard, Haritz Sardon
As the recycling of polymer materials becomes a topic of growing societal importance, there is a need to develop robust methods for dealing with plastic waste. In a recent article in Science, Anastasaki and co-workers report a route for the efficient chemical recycling of commercial polymethacrylates via low-temperature depolymerization using visible light.
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Electrolyte: The cornerstone of commercializing the electrosynthesis of H2O2 Chem (IF 19.1) Pub Date : 2025-03-25 Chang Long, Zhiyong Tang
In this issue of Chem, Strasser and co-workers introduce an electrolyte design that leverages the alkali-metal enhancement effect for the sustainable electrosynthesis of H2O2 from oxygen. This little electrolyte alteration, combined with a cost-effective commercial carbon-based gas-diffusion electrode, represents a significant advancement toward the green production of H2O2.
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Directional self-assembly of organic semi-type core-shell microwires for programmable visible-to-near-infrared waveguiding conversion Chem (IF 19.1) Pub Date : 2025-03-24 Bin Wu, Ming-Peng Zhuo, Ying-Li Shi, Lin-Feng Gu, Yu-Dong Zhao, Yang Su, Yuan-Yuan Li, Hang Lu, Wei-Feng Li, Zuo-Shan Wang, Xue-Dong Wang
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Pilot-scale reductive catalytic depolymerization of lignin: Challenges and guidelines Chem (IF 19.1) Pub Date : 2025-03-24 Brent Daelemans, Paul Jusner, Balaji Sridharan, Miet Van Dael, Kelly Servaes, Karolien Vanbroekhoven, Elias Feghali
The valorization of renewable materials is critical to improving the circularity of the chemical industry. This Synergy article describes how lignin waste streams can be upgraded to valuable resources through reductive catalytic depolymerization. The article presents the challenges linked to the upscaling of this process and offers guidelines for performing the process in a successful and economic
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Electrochemical 6Li isotope enrichment based on selective insertion in 1D tunnel-structured V2O5 Chem (IF 19.1) Pub Date : 2025-03-20 J. Luis Carrillo, Andrew A. Ezazi, Saul Perez-Beltran, Carlos A. Larriuz, Harris Kohl, Jaime A. Ayala, Arnab Maji, Stanislav Verkhoturov, Mohammed Al-Hashimi, Hassan Bazzi, Conan Weiland, Cherno Jaye, Daniel A. Fischer, Lucia Zuin, Jian Wang, Sarbajit Banerjee
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Strained diradicaloids for σ-bond-insertion reactions: A breakthrough in drug discovery Chem (IF 19.1) Pub Date : 2025-03-19 Yoshio Barrera, Florian F. Mulks
Houk, Garg, and colleagues report in Nature a new and intriguing synthetic method for coupling strained cyclic allenes and bicyclo[1.1.0]butanes through σ-bond insertion along a diradical pathway under mild conditions and ambient temperature. Geometric distortion induces diradical behavior, driving the reaction. This study enables the direct synthesis of functionalized bicyclo[2.1.1]hexanes, opening
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Electrophilic selenium drives electron leakage Chem (IF 19.1) Pub Date : 2025-03-17 Ruyi Zhou, Jicheng Yu, Zhen Gu
Disrupting redox homeostasis in cancer cells represents a promising strategy for minimizing toxicity and improving chemotherapy outcomes. In Cell Biomaterials, Chen, Ma, and colleagues describe an approach that employs a selenium electrophilic center with rapid electron-shuttle properties to boost mitochondrial electron leakage and thus convert antioxidants into pro-oxidants for cancer therapy.
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In this issue Chem (IF 19.1) Pub Date : 2025-03-13
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Versatile selective-absorber-based photothermocatalytic reactor for solar fuel synthesis Chem (IF 19.1) Pub Date : 2025-03-13 Fernando Fresno, Nicolas Keller
In this preview, we showcase Peters, Agapie, Atwater, and co-workers’ recent findings published in Device. The team developed a versatile and scalable selective-absorber-based photothermocatalytic reactor for sunlight-driven sustainable fuel synthesis. Ethylene oligomerization reactions using homogeneous and heterogeneous Ni catalysts were efficiently carried out in both batch and flow configurations
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Manipulating alkoxy radicals for site- and enantioselective C–H oxidation Chem (IF 19.1) Pub Date : 2025-03-13 Jian He, Chi-Ming Che
Using C–H substrates as limiting reagents to achieve non-directed C–H activation with high selectivity has been a long-standing challenge in organic synthesis. Recently in Nature Catalysis, Liu et al. introduce a biomimetic catalytic system that employs Cu(II)-bound tert-butoxy radicals for site-selective C–H abstraction, enabling highly efficient asymmetric C(sp3)–H oxidation.
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Intramolecular through-space heavy-atom effect in π-stacked MR-TADF emitters Chem (IF 19.1) Pub Date : 2025-03-13 Sheng-Yi Yang, Cheng Liu, Fei Wang, Ben Zhong Tang
In this issue of Chem, Jiang and colleagues utilized a spiro-fluorene unit as a π-bridge to construct a series of π-stacked multi-resonance thermally activated delayed fluorescence emitters. By introducing different heavy atoms through chemical bonding, they revealed the impact of the intramolecular through-space heavy-atom effect on the optoelectronic properties of the molecules.
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Cartilage-targeting fluorophores for early detection of arthritis in the NIR-II window Chem (IF 19.1) Pub Date : 2025-03-12 Homan Kang, Seung Hun Park, Guliz Ersoy Ozmen, Won Hur, Jason Dinh, Haoran Wang, Vy Nguyen, Sung Ahn, Atsushi Yamashita, Wesley R. Stiles, Satoshi Kashiwagi, Kai Bao, Maged Henary, Hak Soo Choi
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Indocyanine polymethine fluorophores with extended π-conjugation emitting beyond 1,200 nm for enhanced NIR-II imaging Chem (IF 19.1) Pub Date : 2025-03-10 Rui-Tian Ge, Feng Xiong, Zhen-Bang Chen, Yuanjie Wang, Lin Zheng, Jia Zhou, Di Wu, Shu-Yu Zhang
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Why sulfur is important in lincosamide antibiotics Chem (IF 19.1) Pub Date : 2025-03-07 Kelvin J.Y. Wu, Elena V. Aleksandrova, Paul J. Robinson, Amy E. Benedetto, Meiyi Yu, Ben I.C. Tresco, Dominic N.Y. See, Tong Jiang, Antonio Ramkissoon, Clémence F. Dunand, Maxim S. Svetlov, Joonho Lee, Yury S. Polikanov, Andrew G. Myers
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Two (AgI3I)4L4 cages elucidate the rules for silver-cluster vertex design Chem (IF 19.1) Pub Date : 2025-03-07 Andrew W. Heard, Samuel E. Clark, Charlie T. McTernan, Tanya K. Ronson, Petr Rozhin, Barbara Rossi, Silvia Marchesan, Jonathan R. Nitschke
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Photoelectrocatalytic reduction of CO2 to formate using immobilized molecular manganese catalysts on oxidized porous silicon Chem (IF 19.1) Pub Date : 2025-03-07 Young Hyun Hong, Xiaofan Jia, Eleanor Stewart-Jones, Abhishek Kumar, Justin C. Wedal, Jose L. Alvarez-Hernandez, Carrie L. Donley, Albert Gang, Noah J. Gibson, Nilay Hazari, Madison Houck, Sungho Jeon, Jongbeom Kim, Hyeongjun Koh, James M. Mayer, Brandon Q. Mercado, Hannah S. Nedzbala, Nicole Piekut, Christine Quist, Eric Stach, Yihui Zhang
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An unconventional photochemical tetrahydroisoquinoline synthesis from sulfonylimines and alkenes Chem (IF 19.1) Pub Date : 2025-03-06 Wang Wang, Bodi Zhao, Xiaotian Qi, M. Kevin Brown
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Nanoporous synthetic metal: A nickel MOF with an amino-functionalized macrocyclic ligand Chem (IF 19.1) Pub Date : 2025-03-06 Hoai T.B. Pham, Xiaoyu Fang, Ji Yong Choi, Shaofeng Huang, Jihye Park
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Oxygen-tolerant photocatalytic conversion of simulated flue gas to ethylene Chem (IF 19.1) Pub Date : 2025-03-05 Qiong Liu, Hui Cheng, Ching Kit Tommy Wun, Tianxiang Chen, Tsz Woon Benedict Lo, Fuxian Wang
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Soft microrobots for long-span precise stem cell delivery and restoration of neural connections Chem (IF 19.1) Pub Date : 2025-03-06 Engui Zhao, Ting Ma
Precisely navigating stem cells is crucial for enhancing the therapeutic outcomes in treating spinal cord injury (SCI). In a recent study published in Matter, Shen et al. introduced a breakthrough strategy that uses computed tomography (CT)-guided magnetic-driven soft microrobots for long-distance, precise stem cell delivery. This innovative approach offers great potential to accelerate the clinical
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Selenium nanomedicine: From basic science to clinical applications Chem (IF 19.1) Pub Date : 2025-03-06 Lizhen He, Zushuang Xiong, Tianfeng Chen
Selenium (Se) nanoparticles have emerged as promising nanotherapeutic candidates because they demonstrate transformative potential across biomedical domains. Over decades, we have devoted significant effort to their structural engineering, scalable manufacturing, and clinical application. Here, we highlight recent advances in Se nanomedicine for clinical translation and industrial production.
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Dynamic crosslinking of thermoplastics via perfluorophenyl nitrene C–H insertion to form recyclable thermosets Chem (IF 19.1) Pub Date : 2025-03-05 Zhi Yuan Lee, Sirin Kamarulzaman, Rizqullah Rasyiddin, Sheila Y.X. Sim, Georgina E.K.K. Seah, Ai Wei Gan, Zibiao Li, Zhuang Mao Png, Shermin S. Goh
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Strong cation concentration effect of Ni–N–C electrocatalysts in accelerating acidic CO2 reduction reaction Chem (IF 19.1) Pub Date : 2025-03-05 Hyewon Yun, Suhwan Yoo, Jihoon Son, Jae Hyung Kim, Jingwen Wu, Kun Jiang, Hyeyoung Shin, Yun Jeong Hwang
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Efficient electrochemical conversion of nitric oxide to ammonia using a porous nickel catalyst in a membrane electrode assembly electrolyzer Chem (IF 19.1) Pub Date : 2025-03-05 Amrita Singh-Morgan, Kim Trösch, Anna Weinfurter, Michael Inniger, Yuan-Zi Xu, Victor Mougel
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Encapsulation of metal nanoclusters into hydrogen-bonded organic frameworks for double-response-reverse ammonia fluorescence sensing Chem (IF 19.1) Pub Date : 2025-03-04 Yuxin Wang, Jia Yao, Shitao Wu, Chao Zhi, Lifei Yin, Zhengxuan Song, Jing Wang, Lixia Ling, Yanhang Ma, Daliang Zhang, Jinping Li, Libo Li, Banglin Chen
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Effective N2 activation strategies for electrochemical ammonia synthesis Chem (IF 19.1) Pub Date : 2025-03-03 Minghang Jiang, Xi Chen, Fasheng Chen, Mengjun Wang, Xiaojun Luo, Yi He, Caijun Wu, Liyun Zhang, Xiao Li, Xuemei Liao, Zhenju Jiang, Zhong Jin
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Photocatalytic product-selective reduction of CO2, CO, and carbonates Chem (IF 19.1) Pub Date : 2025-02-28 Rohan Bhimpuria, Monika Tomar, Anders Thapper, Mårten Ahlquist, K. Eszter Borbas
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Next-generation de novo luciferases: How artificial intelligence is improving its own designs at light speed Chem (IF 19.1) Pub Date : 2025-02-27 Yosta de Stigter, Maarten Merkx
Advances in artificial intelligence are revolutionizing protein design, and new methods are emerging rapidly. In this issue of Chem, Yeh and co-workers leverage recent deep-learning-based tools to create a series of improved de novo luciferases and color variants that successfully address the limitations of native luciferases.
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Stable crystalline keteniminyl anions Chem (IF 19.1) Pub Date : 2025-02-26 Xin-Feng Wang, Rui Wei, Qiuming Liang, Chaopeng Hu, Liu Leo Liu
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Enantioselective total syntheses of melotenine-, voacafrine-, and tabersonine-type Aspidosperma indole alkaloids Chem (IF 19.1) Pub Date : 2025-02-25 Dong-Xing Tan, Jie Zhou, Cheng-Yu Gu, Ze-Yu Li, Yun-Jie Shen, Fu-She Han
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Site-selective C(sp3)–H oxidation of alkyl substrates devoid of functional handles Chem (IF 19.1) Pub Date : 2025-02-25 Yiheng Lu, Melina Knezevic, Alessandro Prescimone, Bernd Goldfuss, Konrad Tiefenbacher
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Dicobalt-catalyzed N=N coupling reactions of tertiary alkyl azides to form azoalkanes Chem (IF 19.1) Pub Date : 2025-02-24 Kyle B. Brook, Sumeet R. Sahoo, Christopher Uyeda