Herein, Cu2O with different morphology were successfully synthesized by simply adjusting the copper sources via a seed-medium process. Cu2O cubes with uniform size and stacked octahedrons (stacked by the self-assembly of cubic Cu2O) were obtained. The growth mechanism of cubes and stacked octahedrons were studied and applied to non-enzymatic glucose detection. The obtained electrode exhibited excellent

Organophosphorus pesticides (OPs) are widely used in agriculture. However, the residue and accumulation of OPs is a threat to food safety and human health. Thus, a sensitive and accurate OPs detection method is still pursued. Here, we utilized electrostatic adsorption to immobilize weak fluorescent AuNCs on the SiO2 surface, exciting its aggregation-induced emission (AIE) properties and achieving the

This article presents for the first time an ultrasensitive localized surface plasmon resonance (LSPR) sensor system based on multimode-singlemode-multimode fiber (MMF-SMF-MMF) structure for the accurate measurement of copper (II) Ion (Cu2+). Citrate-stabilized [email protected] core-shell nanospheres (NSs) with a rough AgPt alloy outer shell were synthesized in house, and then adhered onto the sensing

A new method and device for the selective measurement of humidity at high temperature is presented. It consists of a TiO2 sensor element and a Fourier-based impedance spectrometry (FobIS) device with a dynamic range from 100 Hz to 100 kHz. For selective humidity detection we use an electrical equivalent circuit model presented earlier [1]. In this model, the humidity can be attributed to a constant

The SERS sensing of nucleic acids (DNA) by coating the plasmonic materials with a biocompatible layer and complementary DNA strands developed an entire stimulating area in biomedical applications, specifically for the diagnosis of malignant diseases. However, the labels and coating increase the overall hydrodynamic size of the plasmonic nano-materials, which restricts the internalization inside the

In this work, an ultrasensitive lab-on-paper device via Cu/Co double-doped CeO2 (CuCo-CeO2) nanospheres as signal amplifiers, being acquiescent to quantitative assay with the dual mode signal readout of electrochemical and visual screening, was constructed for ultrasensitive sensing of miRNA-155. To improve the performance of biosensor, an Au-modified paper-based working electrode was manufactured

In this study, we developed a facile one-pot strategy for immobilizing a covalent organic framework (COF) on an amino-functionalized carbon nanotube (NH2-CNT) support at room temperature. The [email protected]2-CNT composite obtained possessed a high specific surface area (147.3 m2 g−1), and good conductivity when deposited on the glassy carbon electrode (GCE). The [email protected]2-CNT/GCE sensor

Electrochemical surface plasmon resonance (ESPR) is a powerful technique for defining dynamic changes in chemical composition and morphology of functional interfaces by correlating spectral information with voltammetric characteristics of the electrode processes. However, conventional Kretschmann prism-based surface plasmon resonance (SPR) configurations require sophisticated apparatus and complex

The wide use of acetylacetone (Acac) in industries is fueling the need for the development of Acac detection methods. However, only a few nanomaterial-based fluorescent probes for Acac have been reported, and these probes either lack turn-on detection capability, and/or aqueous compatibility. Herein, a series of iridium(III) dimers were synthesized in one step and screened as luminescent probes for

In this work, MoS2 nanosheets decorated with SnO2 nanoparticles were prepared via a facile two-step hydrothermal method, which possesses a proposed sensing composite structure of supporting layer/sensitive dots. The SnO2/MoS2 nanocomposites exhibited an excellent sensing response (2080.36) toward 200 ppm NH3, which was ∼27.5 times higher than that of pristine MoS2 films, a fast response/recovery time

Acetone detection in exhaled breath as a biomarker has been a new method for non-invasive diagnosis of diabetes in medical diagnosis. Here, we fabricated a stabilized zirconia (YSZ) solid electrolyte type acetone sensor based on mixed potential sensing mechanism using Fe2TiO5-TiO2 oxide sensing electrode (SE) prepared by a simple sol-gel method. The acetone sensing performance of the fabricated sensor

Perovskite-type oxides have received considerable attention as sensing electrode (SE) for solid electrolyte type sensors because of their exceptional sensing performance and compositional flexibility. Herein, non-stoichiometric perovskite oxides (La0.75Sr0.25)xCrO3-δ (x = 0.95, 1.0, 1.05) with nano-structure were prepared in porous YSZ backbone by impregnation method as SE for impedancemetric-type

Trakhtenberg, Ilegbusi and Kozhushner, have kindly stated issues and concerns regarding the underlying assumption of our paper entitled “Calculation of the electric potential and surface oxygen ion density for planar and spherical metal oxide grains by numerical solution of the Poisson equation coupled with Boltzmann and Fermi-Dirac statistics”. We believe that this comment is the result of misunderstanding

Whole cell capacitance measurement of a single or few cells at controlled distances gives valuable information on cell activities and intercellular interactions. However, conventional techniques require either averaging the values of uncontrolled number of cells cultured on or between electrodes or altering the cell membrane structure to fit cells into the patch or a narrow capillary. In this study

In this work, we synthesized metal (Au, Ag or Cu)–based nanoclusters (NCs) with different photoluminescence (PL) properties and investigated their application for the specific detection of heavy metal ions in water samples. Bovine serum albumin (BSA) and thiosalicylic acid (TSA) acted as protecting ligands for the synthesis of metallic NCs (MNCs). The as–prepared TSA/BSA–Au NCs, TSA/BSA–Ag NCs and

Hermetic packaging is a suitable means to achieve long lifetime for implantable medical devices. In order to determine the time to failure of the hermetic packages, the prediction of lifetime by helium leakage measurements prior to implantation is state of the art. However, these methods are not applicable to packages with very small internal cavity volumes, as these established methods reach their

The electrical response to changes in relative humidity of sputtered thin silicon-tin films with different chemical compositions was evaluated at room temperature by means of complex impedance spectroscopy in the frequency range of 400 Hz-40 MHz. The results showed that the surface morphology, the level of porosity in the mesoporous region, and the chemical composition of the thin films contributed

The detection of chlorogenic acid in clinic samples for metabolic kinetics study is quite a challenging task due to the low concentration and the lacking of sensitive quantitation methods. In this work, a porous pencil lead electrode (PLE) has been used to detect chlorogenic acid by square wave voltammetry (SWV) technique. The redox potential of chlorogenic acid is at ca. + 0.42V (pH = 3.0) versus

Surface-enhanced Raman scattering (SERS) is a powerful analytic tool that can provide information of molecular structures and composition of analytes. The application of SERS for ultrasensitive detection of chemical and biological molecules has attracted particular interests in recent years. Here, a novel type of three-dimensional SERS substrate with uniform hierarchical nanoflower structures was fabricated

Free biocatalyst such as lipase cannot be recovered and reused; and is extremely unstable in harsh reaction condition. Present study aimed to synthesize hierarchical ordered macro-microporous ZIF-8 structures (MAC-ZIF-8) for encapsulation of nano-Burkholderia cepacia lipase (nano BCL). The synthesized MAC-ZIF-8 has good crystallinity, thermal stability and high surface area which made it suitable for

Exposure to trace amounts of lead is known to harm human health, especially for children, which results in irreversible detriment to brain and nerve development. However, most of the sensor platforms using the colorimetric method to detect lead (II) ions (Pb2+) are difficult to reach a decent limit of detection (LOD) and a large detection range. This work presents a practical method to detect Pb2+

A surface-enhanced Raman scattering (SERS)-based lateral flow assay (LFA) strip using silica-encapsulated gold nanoparticles (Si-AuNPs) was developed for the diagnosis of mosquito-borne diseases—dengue fever, Zika virus, or malaria—which are endemic to tropical regions. To investigate the thermal stability of the SERS nanoprobes, Raman peak intensity variations for AuNPs and Si-AuNPs were measured

Peroxynitrite (ONOO−), as one type of reactive nitrogen species (RNS), is closely related to multiple pathophysiological processes. Visualization of ONOO− in living system is essential for further study of its physiological functions. However, most existing ONOO− fluorescent probes continuously display the aggregation-caused quenching (ACQ). In present research, a new activatable AIEgen fluorescent

A split-type photoelectrochemical (PEC) sensor for procalcitonin (PCT) detection was successfully prepared. This split-type sensor adopted controlled-release strategy, which separated the two processes of antigen-antibody specific recognition and photoelectric conversion, so that the two processes can be performed independently. In addition, CdS sensitized Bi2Sn2O7 is combined for the first time to

Glutathione (GSH) is closely related to many physiological processes, the sensitive determination of GSH is significant to the diagnostic and treatment of the specific diseases. In this work, an activatable bimodal imaging and determination strategy of GSH is proposed based on the nanocomposite of black phosphorus quantum dots (BPQDs) wrapped with manganese dioxide nanosheets ([email protected]2).

This report outlines a versatile novel quenching electrochemiluminescence immunosensor based on electrochemiluminescence (ECL) emission with aggregation induced emission (AIE) from TP−COOH NCs, which was utilized by poly-(styrene-co-maleicanhydride) to wrap on tetraphenylethylene nanocrystals. On the one hand, the cathode emission excited at -1.15 V could reduce emission produced by oxygen from high

Gas identification by a single sensing element is a challenging and promising technology. In this work, a novel strategy to identify gases by a single catalytic combustible sensor working in its linear range is proposed and investigated. In the strategy, a half-wavelength standing wave ultrasonic field is used to catalyze the combustion reaction on the sensing surface, and quantified ultrasonic enhancement

Toxic and corrosive H2S gas is detected using chemoresistive sensors based on CuO/CuFe2O4 core-shell heterostructures, which are characterized by DC resistance measurements, scanning electron microscopy and energy-dispersive X-ray spectroscopy. Exposure to various test gases (CO, H2, NO2, VOCs) reveals low responses. However, unique reactivity towards H2S at low operating temperatures leads to accumulation

Titanium oxide nanotube thin films formed by anodic oxidation of titanium metal exhibit high reactivity towards various gases at high temperatures. To date, various types of gas sensors using titanium oxide nanotube films have been proposed. Previously, we proposed a microscale gas sensor with titanium oxide nanotube thin films fabricated by local anodization of titanium microelectrodes. In this study

In this study, we reported a novel highly ordered nano-micro hierarchical structure on flexible polydimethylsiloxane (PDMS) layer as a SERS stamp for ultrasensitive detection, which can generate huge SERS signals with silver nanoparticles (AgNPs) owing to a multiscale coupling electromagnetic enhancement mechanism. Highly ordered nanowrinkles were prepared by oxygen plasma and stretching treatment

S-layer protein (SLP) is a surface protein present in many bacteria and shows unique self-assemble ability for various applications, but its detection methods are very limited. In this paper, a label-free, highly selective and sensitive assay of SLP was developed by using the TiO2-coated porous silicon (PSi)-based microfluidic biosensor. The PSi-based biosensor could be easily prepared in a microfluidic

An economical and reliable theranostic unit is essential for the detection and treatment of bacterial infections. MRSA is one of the most prevalent superbugs in the world at present, hence requires urgent attention. Here, we present a novel copper-based 3-D porous nanocomposite modified with vancomycin (Van) for simultaneous detection and treatment of methicillin-resistant S. aureus (MRSA). The composite

Early diagnosis of a progressive cancer disease is currently limited due to lack of adequate point-of-care (PoC) diagnostic tools. PoC diagnosis enables detecting early signs of a disease and pave way to disease prevention. Here, we developed an immuno-optomagnetic quantum dots based PoC assay for early detection of a cancer biomarker, human epidermal growth factor receptor-2 (hErbB2) protein in serum

Multiplexed detection of cancer markers is of great value in clinical diagnosis. Herein, we present a new immunoassay method for simultaneous quantification of multiple tumor biomarkers. Our approach integrates photonic crystals (PhC) barcodes with DNA hybridization chain reaction (HCR) to amplify signal. Target biomarkers are captured by primary antibodies which are immobilized onto the PhC barcodes

In this paper, we report chemoselective ligation-assisted self-assembly of DNA walker. Specifically, three kinds of chemoselective ligations including azide-alkyne cycloaddition, oxime ligation, and hydrazone ligation, have been proposed to mediate the self-assembly of DNA walker and to induce the following operation. Then, we present our design that the walking strand of the DNA walker is splitted

Microarrays are key platforms for biomolecule detection owing to their parallelizability and amenability for high-throughput. However, conventional fluorescent microarrays still suffer from low specificity and sensitivity, therefore are unsuitable for detection of low abundance nucleic acids. In this study, we demonstrate a universal microarray platform with high specificity and ultra-sensitivity for