Free bilirubin level is a significant indicator for the diagnosis of jaundice related diseases. Herein, ceria nanocubes are synthesized as catalyst for the direct electrochemical sensor of free bilirubin. The sensor is fabricated by simply modifying screen-printed electrodes with ceria nanocubes and carbon blacks. Owing to the catalytical activity of ceria nanocubes and conductivity of carbon blacks

Considering the adverse effect of rising air pollution on environment and human health, highly selective and trace level sensors are needed. Herein, yttrium (Y) incorporated tin oxide (SnO2) thin film gas sensors have been developed for sub-ppb level detection of NO2 at room-temperature. The undoped and Y-doped (1, 3 and 5 wt%) thin films have been prepared via electron beam deposition technique. The

Golgi apparatus plays an important role in the final processing and packaging of cell secretions. Herein, we first present a new strategy using 2′,3′-O-isopropylideneadenosine (Ade) acting as active site of many molecules in the Golgi and tetraphenylethylene (TPE) with aggregation-induced emission (AIE) characteristics to design and synthesize a fluorescence probe termed as TPE-Ade. The fluorescence

The enzyme monoamine oxidase B (Mao B), which is involved in dopamine metabolism, is an important drug target in Parkinson’s disease (PD). The medical treatment with several Mao B inhibitors is well established but only little personalized since the monitoring of the patients Mao B activity is complex and requires sophisticated laboratory equipment. To demonstrate an approach, which has potential in

The organic electrochemical transistor (OECT) can translate biochemical binding events between a recognition unit and its analyte into an electrical signal. We present an OECT comprising an n-type (electron transporting) conjugated polymer-based channel and lateral gate electrode functionalized with the enzyme, glucose oxidase. The device is integrated with a microfluidic system for real-time glucose

Volatile organic compounds (VOCs) in breath and skin gas are promising samples for non-invasive and simple disease screening and metabolism assessment. In addition, simultaneous measurement of multiple VOCs helps to improve the examination quality and allows for more reliable disease screening and investigation of detailed metabolic pathways. In this study, we have developed a dual-target gas-phase

In this paper, GaON with excellent photoelectrochemical (PEC) performance was adopted in PEC immunosensor for the first time. Based on CdS sensitized BiVO4/GaON composite material, a label-free PEC immunosensor was successfully developed for determination of procalcitonin (PCT). Firstly, BiVO4 nanoarray was prepared by electrodeposition. Then GaON was added to form the BiVO4/GaON composite material

Two dimensional (2D) MXene decorated by the SnO2 nanoparticles has been successfully synthesized by the hydrothermal method. The formed MXene/SnO2 heterojunction based chemirestistive-type sensors exhibit an excellent sensitivity and selectivity to different concentrations of NH3 from 0.5 to 100 ppm at room temperature. The enhanced sensing properties can be attributed to two major factors. On one

Heated metal oxide sensors have been widely studied for their ability to give a reversible change in the electrical resistance following the interaction with a volatile compound. Another feature is their inherent cataluminescence (CTL) properties when these materials interact with specific volatiles. This study reports for the first time a zirconium oxide nanomaterial doped with a rare earth metal

Photothermal sensors represent a novel type of probe having potential in the field of clinical diagnostics particularly due to the lack of a tedious sample pre-treatment, a sophisticated equipment and a skilled manpower. Herein, we describe the fabrication of a microfluidic nickel-resistive temperature detector (micro-Ni-RTD) for the selective monitoring of diabetes using a boronate-based sialic acid

A novel quantitative approach of multidimensional interactive sensing based on information entropy was developed for the rapid determination of rice quality. Electronic tongue with multi-metal sensor array was employed. Physicochemical indexes including chalkiness, gel consistency, amylose, protein, starch and total metal element content which are the major indicators for rice quality were analyzed

This paper presents the numerical analysis and Taguchi optimization of fluid mixing by alternating current electrothermal flow (ACET) in a Y-shape microchannel. In the numerical study, ACET is simulated through the interaction of a non-uniform electric field provided through co-planar electrodes and the temperature gradients produced by a micro-heater. To achieve the efficient ACET mixing of fluids

We show a facile and inexpensive way, termed as plasmonics induced surface modification (PISM), to modify large-scale plasmonic nanostructures by growing Ag nanoislands (NIs) onto their surface merely by simple LED-irradiation. Both the size and density of the Ag NIs can be well regulated by adjusting the irradiating duration. The NIs modification in this system is ascribed to the photocatalytic effect

A novel portable and cost-effective multi-wavelength smartphone colorimetric reader (MW-SCR) was designed for the quantitation of liquid colorimetric assays. Six light-emitting diodes (LEDs) with different wavelengths were assembled in a roulette fashion to form the light detection source. An ambient light sensor of smartphone was applied as the detector. Using this MW-SCR, we detected six common serum

This study produces Co3O4 nanoparticles (NPs) using ultrasonic wave grinding technology. The experimental results show that the average diameter of Co3O4-NPs is about 6 nm. Au nanoparticles are adsorbed onto the surface of Co3O4-NPs and integrated with a MEMS structure to form a Au/Co3O4-NPs/MEMS NO2 gas sensor. The diameter of Au nanoparticle is approximately 1 nm. For a 100-ppb NO2 gas concentration

The unique multiple barrier characteristics of heterojunctions significantly change the electrical and optical properties of semiconductor composites, and also affect the temperature and response rate of gas-sensitive detection. In this paper, the as-obtained ZnO/In2O3 nanocomposites achieve rapid detection of ppb-level NO2 gas at room temperature through resonance tunneling modulation. The ZnO nanosheets

Gas sensing technology is becoming increasingly important in environmental monitoring, medical diagnostics, and industrial safety. Among various types of gas sensors, FET-type gas sensors are increasingly attracting attention due to their miniaturized size, low power consumption, high reliability, and good compatibility with CMOS technology. Therefore, it would be helpful to review how FET-type gas

We investigated the power-law responses in two types of tin dioxide (SnO2) films: one made from nanosized grains and another from from very large grains, both under dry air. Experimental results revealed a significant dependence between the sensitivity and the SnO2 grain size. We therefore propose, that the gas sensor sensitivity is not only determined by oxygen chemisorption, but also by changes in

Early accurate profiling of pathogenic bacteria in patients with nosocomial bloodstream infections (nBSIs) is crucial to optimize antibiotic therapy and patient survival. We present a novel autocatalytic Multi-component DNAzyme (MNAzyme)-integrated surface plasmon resonance (SPR) biosensor assay that rapidly and sensitively detects the DNA of three nBSI pathogenic bacteria. This strategy combines autocatalytic

Intrinsically n-doped a-plane and c-plane GaN thin films were successfully deposited on r-plane and c-plane sapphire substrates, respectively, by metalorganic vapor phase epitaxy (MOVPE). The c-plane GaN sensor shows a response value of 5.23 to 200 ppm triethylamine (TEA) at 480 °C, much higher than the a-plane one at the same condition. The TEA vapor is detectable down to its threshold value of 1 ppm

The invasion of pathogens into the bloodstream can produce a systemic inflammatory response syndrome that, if not promptly treated, rapidly evolves in acute life-threatening dysfunction of remote organs (septic shock). Current conventional diagnostic tests are microbial blood cultures that need days for results. Therefore, it is crucial the availability of rapid and reliable pathogens detection for

The detection of urban pests, such as bed bugs, has economic and human health implications. The current methods of insect detection leveraged in daily practice include visual inspection; passive interception devices, such as sticky traps; and active monitoring traps, which exude odors that the insects are attracted to. This paper describes recent advancements related to the resonant sensing of trans-2-hexenal

Heterostructures of metal oxide semiconductors have a great promise for chemical gas sensors due to the peculiar properties at the heterointerface. In this work, a highly sensitive and selective gas sensor for detecting formaldehyde is reported based on SnO2/ZnO heterospheres designed by atomic layer deposition (ALD). The electronic properties at the SnO2/ZnO heterointerface can be modulated by optimizing

Combining imaging and treatment of cancer into one molecule has become an efficient strategy for studies on pathology and cancer therapeutics. Herein, a novel highly selective and sensitive green-emitting probe (APLN), which contained a fluorophore (Naphthalimide), a linker, and a COX-2 kinase inhibitor (aspirin) has been designed and evaluated. Cyclooxygenase-2 (COX-2), as one of the typical rate-limiting

Cell/particle separation enabled by lab-on-a-chip (LOC) devices has been a promising solution for separating target cells from the body fluids. Understanding the effects of fabrication and performance parameters on the separation efficiency can further advance applications of such devices in life sciences. This study presents a parametric study on the displacement of the cell-representative polystyrene

Here we present a novel glucometer-based microfluidic platform using miniaturized personal glucose meter (PGM) with portability and simple operation to sensitively detect cancer biomarker via amplification of rolling cycle amplification (RCA) associated with DNA-invertase catalysis. This design utilizes gold nanoparticles (Au NPs) as a supporting matrix to anchor Human Epidermal Growth Factor Receptor

Excessively-used imidacloprid (IMI) leads to considerable pollutions. Feasible and reliable IMI detections are in great need. Therefore, we introduce the ratiometric IMI analysis on a flexibly-fabricated vibratory electrode module. In this system, β-cyclodextrin is chosen as a supramolecular recognizer to capture IMI, and Prussian blue (PB) acts as an internal reference. The reference current (IPB)

Fast and accurate test Cr(VI) in the whole blood is particularly critical for the treatment and prevention of Cr(VI) poisoning. Here, a blood compatible, high-efficient sensor based on the magnetic glassy carbon electrode (MGCE) that modified by conductive polyaniline (PANI), heparin and tannin modified Fe3O4 nanoparticles (magnetic tannin-modified adsorbent, MTA) with high adsorption ability toward

Proteins play important roles in mediating various forms of life activities. The development of convenient and reliable strategies for simultaneous recognition of multiple proteins is meaningful for early diagnostics of diseases. Herein, we develop a differential colorimetric sensor array, which is made of nonspecific single-stranded DNA (ssDNA) as receptors and gold nanoparticles (AuNPs) as colorimetric

Microalgae single-cell electrochemical characteristics are playing an important key role in its industrial application and functionality. This study conducted a single-cell electrochemical study to explain the influence mechanism of intracellular phenolic and flavonoid contents of microalgae on its surface electric charge. In the method, four microalgae species, Arthrospira platensis (AP), Chlorella

We have used for the first time a conjugated redox polymer with hydroquinone (HQ) pendant groups covalently attached to the poly(3,4-ethylenedioxythiophene) (PEDOT) backbone as the solid contact (SC) in plasticized poly(vinyl chloride) (PVC) based K+-selective electrodes (K-SCISE). Redox couples are one of the simplest ways to precisely adjust the standard potential (E°) of the SCISEs, but usually