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H5N1 clade 2.3.4.4b dynamics in experimentally infected calves and cows Nature (IF 50.5) Pub Date : 2024-09-25 Nico Joel Halwe, Konner Cool, Angele Breithaupt, Jacob Schön, Jessie D. Trujillo, Mohammed Nooruzzaman, Taeyong Kwon, Ann Kathrin Ahrens, Tobias Britzke, Chester D. McDowell, Ronja Piesche, Gagandeep Singh, Vinicius Pinho dos Reis, Sujan Kafle, Anne Pohlmann, Natasha N. Gaudreault, Björn Corleis, Franco Matias Ferreyra, Mariano Carossino, Udeni B. R. Balasuriya, Lisa Hensley, Igor Morozov, Lina M.
In March 2024, highly pathogenic avian influenza virus (HPAIV) clade 2.3.4.4b H5N1 infections in dairy cows were first reported from Texas, USA1. Rapid dissemination to more than 190 farms in 13 states followed2. Here, we provide results of two independent clade 2.3.4.4b experimental infection studies evaluating (i) oronasal susceptibility and transmission in calves to a US H5N1 bovine isolate genotype
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The evolution of private reputations in information-abundant landscapes Nature (IF 50.5) Pub Date : 2024-09-25 Sebastián Michel-Mata, Mari Kawakatsu, Joseph Sartini, Taylor A. Kessinger, Joshua B. Plotkin, Corina E. Tarnita
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Forest fire size amplifies postfire land surface warming Nature (IF 50.5) Pub Date : 2024-09-25 Jie Zhao, Chao Yue, Jiaming Wang, Stijn Hantson, Xianli Wang, Binbin He, Guangyao Li, Liang Wang, Hongfei Zhao, Sebastiaan Luyssaert
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Future increase in extreme El Niño supported by past glacial changes Nature (IF 50.5) Pub Date : 2024-09-25 Kaustubh Thirumalai, Pedro N. DiNezio, Judson W. Partin, Dunyu Liu, Kassandra Costa, Allison Jacobel
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On human-in-the-loop optimization of human–robot interaction Nature (IF 50.5) Pub Date : 2024-09-25 Patrick Slade, Christopher Atkeson, J. Maxwell Donelan, Han Houdijk, Kimberly A. Ingraham, Myunghee Kim, Kyoungchul Kong, Katherine L. Poggensee, Robert Riener, Martin Steinert, Juanjuan Zhang, Steven H. Collins
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Intragenic DNA inversions expand bacterial coding capacity Nature (IF 50.5) Pub Date : 2024-09-25 Rachael B. Chanin, Patrick T. West, Jakob Wirbel, Matthew O. Gill, Gabriella Z. M. Green, Ryan M. Park, Nora Enright, Arjun M. Miklos, Angela S. Hickey, Erin F. Brooks, Krystal K. Lum, Ileana M. Cristea, Ami S. Bhatt
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Transferrin receptor targeting chimeras for membrane protein degradation Nature (IF 50.5) Pub Date : 2024-09-25 Dingpeng Zhang, Jhoely Duque-Jimenez, Francesco Facchinetti, Garyk Brixi, Kaitlin Rhee, William W. Feng, Pasi A. Jänne, Xin Zhou
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The genetic architecture of protein stability Nature (IF 50.5) Pub Date : 2024-09-25 Andre J. Faure, Aina Martí-Aranda, Cristina Hidalgo-Carcedo, Antoni Beltran, Jörn M. Schmiedel, Ben Lehner
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Larger and more instructable language models become less reliable Nature (IF 50.5) Pub Date : 2024-09-25 Lexin Zhou, Wout Schellaert, Fernando Martínez-Plumed, Yael Moros-Daval, Cèsar Ferri, José Hernández-Orallo
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Human hippocampal and entorhinal neurons encode the temporal structure of experience Nature (IF 50.5) Pub Date : 2024-09-25 Pawel Tacikowski, Güldamla Kalender, Davide Ciliberti, Itzhak Fried
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Jet stream controls on European climate and agriculture since 1300 ce Nature (IF 50.5) Pub Date : 2024-09-25 Guobao Xu, Ellie Broadman, Isabel Dorado-Liñán, Lara Klippel, Matthew Meko, Ulf Büntgen, Tom De Mil, Jan Esper, Björn Gunnarson, Claudia Hartl, Paul J. Krusic, Hans W. Linderholm, Fredrik C. Ljungqvist, Francis Ludlow, Momchil Panayotov, Andrea Seim, Rob Wilson, Diana Zamora-Reyes, Valerie Trouet
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AARS1 and AARS2 sense l-lactate to regulate cGAS as global lysine lactyltransferases Nature (IF 50.5) Pub Date : 2024-09-25 Heyu Li, Chao Liu, Ran Li, Lili Zhou, Yu Ran, Qiqing Yang, Huizhe Huang, Huasong Lu, Hai Song, Bing Yang, Heng Ru, Shixian Lin, Long Zhang
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Microbial iron limitation in the ocean’s twilight zone Nature (IF 50.5) Pub Date : 2024-09-25 Jingxuan Li, Lydia Babcock-Adams, Rene M. Boiteau, Matthew R. McIlvin, Lauren E. Manck, Matthias Sieber, Nathan T. Lanning, Randelle M. Bundy, Xiaopeng Bian, Iulia-Mădălina Ștreangă, Benjamin N. Granzow, Matthew J. Church, Jessica N. Fitzsimmons, Seth G. John, Tim M. Conway, Daniel J. Repeta
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Brazilian fossils reveal homoplasy in the oldest mammalian jaw joint Nature (IF 50.5) Pub Date : 2024-09-25 James R. G. Rawson, Agustín G. Martinelli, Pamela G. Gill, Marina B. Soares, Cesar L. Schultz, Emily J. Rayfield
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Designed endocytosis-inducing proteins degrade targets and amplify signals Nature (IF 50.5) Pub Date : 2024-09-25 Buwei Huang, Mohamad Abedi, Green Ahn, Brian Coventry, Isaac Sappington, Cong Tang, Rong Wang, Thomas Schlichthaerle, Jason Z. Zhang, Yujia Wang, Inna Goreshnik, Ching Wen Chiu, Adam Chazin-Gray, Sidney Chan, Stacey Gerben, Analisa Murray, Shunzhi Wang, Jason O’Neill, Li Yi, Ronald Yeh, Ayesha Misquith, Anitra Wolf, Luke M. Tomasovic, Dan I. Piraner, Maria J. Duran Gonzalez, Nathaniel R. Bennett, Preetham
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Bendable non-silicon RISC-V microprocessor Nature (IF 50.5) Pub Date : 2024-09-25 Emre Ozer, Jedrzej Kufel, Shvetank Prakash, Alireza Raisiardali, Olof Kindgren, Ronald Wong, Nelson Ng, Damien Jausseran, Feras Alkhalil, David Kong, Gage Hills, Richard Price, Vijay Janapa Reddi
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Using both faces of polar semiconductor wafers for functional devices Nature (IF 50.5) Pub Date : 2024-09-25 Len van Deurzen, Eungkyun Kim, Naomi Pieczulewski, Zexuan Zhang, Anna Feduniewicz-Zmuda, Mikolaj Chlipala, Marcin Siekacz, David Muller, Huili Grace Xing, Debdeep Jena, Henryk Turski
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The type 2 cytokine Fc–IL-4 revitalizes exhausted CD8+ T cells against cancer Nature (IF 50.5) Pub Date : 2024-09-25 Bing Feng, Zhiliang Bai, Xiaolei Zhou, Yang Zhao, Yu-Qing Xie, Xinyi Huang, Yang Liu, Tom Enbar, Rongrong Li, Yi Wang, Min Gao, Lucia Bonati, Mei-Wen Peng, Weilin Li, Bo Tao, Mélanie Charmoy, Werner Held, J. Joseph Melenhorst, Rong Fan, Yugang Guo, Li Tang
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Nitrogen-doped amorphous monolayer carbon Nature (IF 50.5) Pub Date : 2024-09-25 Xiuhui Bai, Pengfei Hu, Ang Li, Youwei Zhang, Aowen Li, Guangjie Zhang, Yufeng Xue, Tianxing Jiang, Zezhou Wang, Hanke Cui, Jianxin Kang, Hewei Zhao, Lin Gu, Wu Zhou, Li-Min Liu, Xiaohui Qiu, Lin Guo
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Phages reconstitute NAD+ to counter bacterial immunity Nature (IF 50.5) Pub Date : 2024-09-25 Ilya Osterman, Hadar Samra, Francois Rousset, Elena Loseva, Maxim Itkin, Sergey Malitsky, Erez Yirmiya, Adi Millman, Rotem Sorek
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Single-cell multi-omics map of human fetal blood in Down syndrome Nature (IF 50.5) Pub Date : 2024-09-25 Andrew R. Marderstein, Marco De Zuani, Rebecca Moeller, Jon Bezney, Evin M. Padhi, Shuo Wong, Tim H. H. Coorens, Yilin Xie, Haoliang Xue, Stephen B. Montgomery, Ana Cvejic
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Single-cell CAR T atlas reveals type 2 function in 8-year leukaemia remission Nature (IF 50.5) Pub Date : 2024-09-25 Zhiliang Bai, Bing Feng, Susan E. McClory, Beatriz Coutinho de Oliveira, Caroline Diorio, Céline Gregoire, Bo Tao, Luojia Yang, Ziran Zhao, Lei Peng, Giacomo Sferruzza, Liqun Zhou, Xiaolei Zhou, Jessica Kerr, Alev Baysoy, Graham Su, Mingyu Yang, Pablo G. Camara, Sidi Chen, Li Tang, Carl H. June, J. Joseph Melenhorst, Stephan A. Grupp, Rong Fan
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Direct evidence for a carbon–carbon one-electron σ-bond Nature (IF 50.5) Pub Date : 2024-09-25 Takuya Shimajiri, Soki Kawaguchi, Takanori Suzuki, Yusuke Ishigaki
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Structural basis of archaeal FttA-dependent transcription termination Nature (IF 50.5) Pub Date : 2024-09-25 Linlin You, Chengyuan Wang, Vadim Molodtsov, Konstantin Kuznedelov, Xinyi Miao, Breanna R. Wenck, Paul Ulisse, Travis J. Sanders, Craig J. Marshall, Emre Firlar, Jason T. Kaelber, Thomas J. Santangelo, Richard H. Ebright
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The global H5N1 influenza panzootic in mammals Nature (IF 50.5) Pub Date : 2024-09-24 Thomas Peacock, Louise Moncla, Gytis Dudas, David VanInsberghe, Ksenia Sukhova, James O. Lloyd-Smith, Michael Worobey, Anice C. Lowen, Martha I. Nelson
Influenza A viruses (IAV) have caused more documented global pandemics in human history than any other pathogen1,2. High pathogenicity avian influenza (HPAI) viruses belonging to the H5N1 subtype are a leading pandemic risk. Two decades after H5N1 “bird flu” became established in poultry in Southeast Asia, its descendants have resurged3, setting off an H5N1 panzootic in wild birds that is fueled by
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Promises and challenges of crop translational genomics Nature (IF 50.5) Pub Date : 2024-09-23 Martin Mascher, Murukarthick Jayakodi, Hyeonah Shim, Nils Stein
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Rules of river avulsion change downstream Nature (IF 50.5) Pub Date : 2024-09-18 James H. Gearon, Harrison K. Martin, Clarke DeLisle, Eric A. Barefoot, David Mohrig, Chris Paola, Douglas A. Edmonds
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A lymphocyte chemoaffinity axis for lung, non-intestinal mucosae and CNS Nature (IF 50.5) Pub Date : 2024-09-18 Borja Ocón, Menglan Xiang, Yuhan Bi, Serena Tan, Kevin Brulois, Aiman Ayesha, Manali Kunte, Catherine Zhou, Melissa LaJevic, Nicole Lazarus, Francesca Mengoni, Tanya Sharma, Stephen Montgomery, Jody E. Hooper, Mian Huang, Tracy Handel, John R. D. Dawson, Irina Kufareva, Brian A. Zabel, Junliang Pan, Eugene C. Butcher
Tissue-selective chemoattractants direct lymphocytes to epithelial surfaces to establish local immune environments, regulate immune responses to food antigens and commensal organisms, and protect from pathogens. Homeostatic chemoattractants for small intestines, colon, and skin are known1 2, but chemotropic mechanisms selective for respiratory tract and other non-intestinal mucosal tissues (NIMT) remain
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Advanced CMOS manufacturing of superconducting qubits on 300 mm wafers Nature (IF 50.5) Pub Date : 2024-09-18 J. Van Damme, S. Massar, R. Acharya, Ts. Ivanov, D. Perez Lozano, Y. Canvel, M. Demarets, D. Vangoidsenhoven, Y. Hermans, J. G. Lai, A. M. Vadiraj, M. Mongillo, D. Wan, J. De Boeck, A. Potočnik, K. De Greve
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Opto-twistronic Hall effect in a three-dimensional spiral lattice Nature (IF 50.5) Pub Date : 2024-09-18 Zhurun Ji, Yuzhou Zhao, Yicong Chen, Ziyan Zhu, Yuhui Wang, Wenjing Liu, Gaurav Modi, Eugene J. Mele, Song Jin, Ritesh Agarwal
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Commensal consortia decolonize Enterobacteriaceae via ecological control Nature (IF 50.5) Pub Date : 2024-09-18 Munehiro Furuichi, Takaaki Kawaguchi, Marie-Madlen Pust, Keiko Yasuma-Mitobe, Damian R. Plichta, Naomi Hasegawa, Takashi Ohya, Shakti K. Bhattarai, Satoshi Sasajima, Yoshimasa Aoto, Timur Tuganbaev, Mizuki Yaginuma, Masahiro Ueda, Nobuyuki Okahashi, Kimiko Amafuji, Yuko Kiridoshi, Kayoko Sugita, Martin Stražar, Julian Avila-Pacheco, Kerry Pierce, Clary B. Clish, Ashwin N. Skelly, Masahira Hattori,
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One step from oxides to sustainable bulk alloys Nature (IF 50.5) Pub Date : 2024-09-18 Shaolou Wei, Yan Ma, Dierk Raabe
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Temporal BMP4 effects on mouse embryonic and extraembryonic development Nature (IF 50.5) Pub Date : 2024-09-18 Ron Hadas, Hernan Rubinstein, Markus Mittnenzweig, Yoav Mayshar, Raz Ben-Yair, Saifeng Cheng, Alejandro Aguilera-Castrejon, Netta Reines, Ayelet-Hashahar Orenbuch, Aviezer Lifshitz, Dong-Yuan Chen, Michael B. Elowitz, Magdalena Zernicka-Goetz, Jacob H. Hanna, Amos Tanay, Yonatan Stelzer
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Two-factor authentication underpins the precision of the piRNA pathway Nature (IF 50.5) Pub Date : 2024-09-18 Madeleine Dias Mirandela, Ansgar Zoch, Jessica Leismann, Shaun Webb, Rebecca V. Berrens, Devisree Valsakumar, Yuka Kabayama, Tania Auchynnikava, Martina Schito, Tamoghna Chowdhury, David MacLeod, Xinyu Xiang, Juan Zou, Juri Rappsilber, Robin C. Allshire, Philipp Voigt, Atlanta G. Cook, Joan Barau, Dónal O’Carroll
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Controlled patterning of crystalline domains by frontal polymerization Nature (IF 50.5) Pub Date : 2024-09-18 Justine E. Paul, Yuan Gao, Yoo Kyung Go, Luis E. Rodriguez Koett, Anisha Sharma, Manxin Chen, Jacob J. Lessard, Tolga Topkaya, Cecilia Leal, Jeffrey S. Moore, Philippe H. Geubelle, Nancy R. Sottos
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Observation of quantum entanglement with top quarks at the ATLAS detector Nature (IF 50.5) Pub Date : 2024-09-18
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Mars’s induced magnetosphere can degenerate Nature (IF 50.5) Pub Date : 2024-09-18 Qi Zhang, Stas Barabash, Mats Holmstrom, Xiao-dong Wang, Yoshifumi Futaana, Christopher M. Fowler, Robin Ramstad, Hans Nilsson
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Black hole jets on the scale of the cosmic web Nature (IF 50.5) Pub Date : 2024-09-18 Martijn S. S. L. Oei, Martin J. Hardcastle, Roland Timmerman, Aivin R. D. J. G. I. B. Gast, Andrea Botteon, Antonio C. Rodriguez, Daniel Stern, Gabriela Calistro Rivera, Reinout J. van Weeren, Huub J. A. Röttgering, Huib T. Intema, Francesco de Gasperin, S. G. Djorgovski
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Three-dimensional wave breaking Nature (IF 50.5) Pub Date : 2024-09-18 M. L. McAllister, S. Draycott, R. Calvert, T. Davey, F. Dias, T. S. van den Bremer
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Micronuclear battery based on a coalescent energy transducer Nature (IF 50.5) Pub Date : 2024-09-18 Kai Li, Congchong Yan, Junren Wang, Kun Zhu, Junjun Guo, Yugang Zhang, Guozheng Shi, Yuchen Yin, Liwei Cheng, Liang Sun, Yumin Wang, Hailong Zhang, Ying Sun, Jianyu Yuan, Wanli Ma, Guoxun Ji, Zhifang Chai, Yaxing Wang, Xiaoping Ouyang, Shuao Wang
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Endogenous opioid signalling regulates spinal ependymal cell proliferation Nature (IF 50.5) Pub Date : 2024-09-18 Wendy W. S. Yue, Kouki K. Touhara, Kenichi Toma, Xin Duan, David Julius
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Targeted protein relocalization via protein transport coupling Nature (IF 50.5) Pub Date : 2024-09-18 Christine S. C. Ng, Aofei Liu, Bianxiao Cui, Steven M. Banik
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Dynamic transition and Galilean relativity of current-driven skyrmions Nature (IF 50.5) Pub Date : 2024-09-18 Max T. Birch, Ilya Belopolski, Yukako Fujishiro, Minoru Kawamura, Akiko Kikkawa, Yasujiro Taguchi, Max Hirschberger, Naoto Nagaosa, Yoshinori Tokura
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Observation-constrained projections reveal longer-than-expected dry spells Nature (IF 50.5) Pub Date : 2024-09-18 Irina Y. Petrova, Diego G. Miralles, Florent Brient, Markus G. Donat, Seung-Ki Min, Yeon-Hee Kim, Margot Bador
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Pathogenic hypothalamic extracellular matrix promotes metabolic disease Nature (IF 50.5) Pub Date : 2024-09-18 Cait A. Beddows, Feiyue Shi, Anna L. Horton, Sagar Dalal, Ping Zhang, Chang-Chun Ling, V. Wee Yong, Kim Loh, Ellie Cho, Chris Karagiannis, Adam J. Rose, Magdalene K. Montgomery, Paul Gregorevic, Matthew J. Watt, Nicolle H. Packer, Benjamin L. Parker, Robyn M. Brown, Edward S. X. Moh, Garron T. Dodd
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Space radiation measurements during the Artemis I lunar mission Nature (IF 50.5) Pub Date : 2024-09-18 Stuart P. George, Ramona Gaza, Daniel Matthiä, Diego Laramore, Jussi Lehti, Thomas Campbell-Ricketts, Martin Kroupa, Nicholas Stoffle, Karel Marsalek, Bartos Przybyla, Mena Abdelmelek, Joachim Aeckerlein, Amir A. Bahadori, Janet Barzilla, Matthias Dieckmann, Michael Ecord, Ricky Egeland, Timo Eronen, Dan Fry, Bailey H. Jones, Christine E. Hellweg, Jordan Houri, Robert Hirsh, Mika Hirvonen, Scott Hovland
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Genetic links between ovarian ageing, cancer risk and de novo mutation rates Nature (IF 50.5) Pub Date : 2024-09-11 Stasa Stankovic, Saleh Shekari, Qin Qin Huang, Eugene J. Gardner, Erna V. Ivarsdottir, Nick D. L. Owens, Nasim Mavaddat, Ajuna Azad, Gareth Hawkes, Katherine A. Kentistou, Robin N. Beaumont, Felix R. Day, Yajie Zhao, Hakon Jonsson, Thorunn Rafnar, Vinicius Tragante, Gardar Sveinbjornsson, Asmundur Oddsson, Unnur Styrkarsdottir, Julius Gudmundsson, Simon N. Stacey, Daniel F. Gudbjartsson, Kitale Kennedy
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Ultrahigh electromechanical response from competing ferroic orders Nature (IF 50.5) Pub Date : 2024-09-11 Baichen Lin, Khuong Phuong Ong, Tiannan Yang, Qibin Zeng, Hui Kim Hui, Zhen Ye, Celine Sim, Zhihao Yen, Ping Yang, Yanxin Dou, Xiaolong Li, Xingyu Gao, Chee Kiang Ivan Tan, Zhi Shiuh Lim, Shengwei Zeng, Tiancheng Luo, Jinlong Xu, Xin Tong, Patrick Wen Feng Li, Minqin Ren, Kaiyang Zeng, Chengliang Sun, Seeram Ramakrishna, Mark B. H. Breese, Chris Boothroyd, Chengkuo Lee, David J. Singh, Yeng Ming Lam
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Brain-wide dynamics linking sensation to action during decision-making Nature (IF 50.5) Pub Date : 2024-09-11 Andrei Khilkevich, Michael Lohse, Ryan Low, Ivana Orsolic, Tadej Bozic, Paige Windmill, Thomas D. Mrsic-Flogel
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Observing the two-dimensional Bose glass in an optical quasicrystal Nature (IF 50.5) Pub Date : 2024-09-11 Jr-Chiun Yu, Shaurya Bhave, Lee Reeve, Bo Song, Ulrich Schneider
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The emerging view on the origin and early evolution of eukaryotic cells Nature (IF 50.5) Pub Date : 2024-09-11 Julian Vosseberg, Jolien J. E. van Hooff, Stephan Köstlbacher, Kassiani Panagiotou, Daniel Tamarit, Thijs J. G. Ettema
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Promotion of DNA end resection by BRCA1–BARD1 in homologous recombination Nature (IF 50.5) Pub Date : 2024-09-11 Sameer Salunkhe, James M. Daley, Hardeep Kaur, Nozomi Tomimatsu, Chaoyou Xue, Vivek B. Raina, Angela M. Jasper, Cody M. Rogers, Wenjing Li, Shuo Zhou, Rahul Mojidra, Youngho Kwon, Qingming Fang, Jae-Hoon Ji, Aida Badamchi Shabestari, O’Taveon Fitzgerald, Hoang Dinh, Bipasha Mukherjee, Amyn A. Habib, Robert Hromas, Alexander V. Mazin, Elizabeth V. Wasmuth, Shaun K. Olsen, David S. Libich, Daohong Zhou
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Connectome-constrained networks predict neural activity across the fly visual system Nature (IF 50.5) Pub Date : 2024-09-11 Janne K. Lappalainen, Fabian D. Tschopp, Sridhama Prakhya, Mason McGill, Aljoscha Nern, Kazunori Shinomiya, Shin-ya Takemura, Eyal Gruntman, Jakob H. Macke, Srinivas C. Turaga
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Self-organized tissue mechanics underlie embryonic regulation Nature (IF 50.5) Pub Date : 2024-09-11 Paolo Caldarelli, Alexander Chamolly, Aurélien Villedieu, Olinda Alegria-Prévot, Carole Phan, Jerome Gros, Francis Corson
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Stereospecific radical coupling with a non-natural photodecarboxylase Nature (IF 50.5) Pub Date : 2024-09-10 Vasilis Tseliou, Laura Kqiku, Martin Berger, Florian Schiel, Hangyu Zhou, Gerrit J. Poelarends, Paolo Melchiorre
Photoenzymes are light-powered biocatalysts that typically rely on the excitation of cofactors or unnatural amino acids for their catalytic activities1,2. A notable natural example is the fatty acid photodecarboxylase (FAP), which uses light energy to convert aliphatic carboxylic acids to achiral hydrocarbons3. Here, we report a way to design a non-natural photodecarboxylase based on the excitation
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Gasdermin D-mediated metabolic crosstalk promotes tissue repair Nature (IF 50.5) Pub Date : 2024-09-11 Zhexu Chi, Sheng Chen, Dehang Yang, Wenyu Cui, Yang Lu, Zhen Wang, Mobai Li, Weiwei Yu, Jian Zhang, Yu Jiang, Ruya Sun, Qianzhou Yu, Tianyi Hu, Xiaoyang Lu, Qiqi Deng, Yidong Yang, Tianming Zhao, Mengfei Chang, Yuying Li, Xue Zhang, Min Shang, Qian Xiao, Kefeng Ding, Di Wang
The establishment of an early pro-regenerative niche is crucial for tissue regeneration1,2. Gasdermin D (GSDMD)-dependent pyroptosis accounts for the release of inflammatory cytokines upon various insults3-5. However, little is known about its role in tissue regeneration followed by homeostatic maintenance. Here, we show that macrophage GSDMD deficiency delayed tissue recovery, with little impact on
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Structure of human TIP60-C histone exchange and acetyltransferase complex Nature (IF 50.5) Pub Date : 2024-09-11 Changqing Li, Ekaterina Smirnova, Charlotte Schnitzler, Corinne Crucifix, Jean Paul Concordet, Alice Brion, Arnaud Poterszman, Patrick Schultz, Gabor Papai, Adam Ben-Shem
Chromatin structure is a key regulator of DNA transcription, replication, and repair1. In humans, the TIP60/EP400 complex (TIP60-C) is a 20-subunit assembly that impacts chromatin structure via two enzymatic activities: ATP-dependent exchange of histone H2A/H2B for H2A.Z/H2B and histone acetylation, which in yeast are carried out by two independent complexes, SWR1 and NuA4, respectively2,3. How these
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Heteromeric amyloid filaments of ANXA11 and TDP-43 in FTLD-TDP Type C Nature (IF 50.5) Pub Date : 2024-09-11 Diana Arseni, Takashi Nonaka, Max H. Jacobsen, Alexey G. Murzin, Laura Cracco, Sew Y. Peak-Chew, Holly J. Garringer, Ito Kawakami, Hisaomi Suzuki, Misumoto Onaya, Yuko Saito, Shigeo Murayama, Changiz Geula, Ruben Vidal, Kathy L. Newell, Marsel Mesulam, Bernardino Ghetti, Masato Hasegawa, Benjamin Ryskeldi-Falcon
Neurodegenerative diseases are characterised by the abnormal filamentous assembly of specific proteins in the central nervous system1. Human genetic studies established a causal role for protein assembly in neurodegeneration2. However, the underlying molecular mechanisms remain largely unknown, which is limiting progress in developing clinical tools for these diseases. Recent advances in electron cryo-microscopy
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One month convection timescale on the surface of a giant evolved star Nature (IF 50.5) Pub Date : 2024-09-11 Wouter Vlemmings, Theo Khouri, Behzad Bojnordi Arbab, Elvire De Beck, Matthias Maercker
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Two-dimensional-lattice-confined single-molecule-like aggregates Nature (IF 50.5) Pub Date : 2024-09-11 Kang Wang, Zih-Yu Lin, Angana De, Conrad A. Kocoj, Wenhao Shao, Hanjun Yang, Zehua He, Aidan H. Coffey, Colton B. Fruhling, Yuanhao Tang, Dharini Varadharajan, Chenhui Zhu, Yong Sheng Zhao, Alexandra Boltasseva, Vladimir M. Shalaev, Peijun Guo, Brett M. Savoie, Letian Dou