In this issue of Chem, Song and co-workers report a novel chemodynamic and chemiluminescent system. This system exhibited the acid-stimulated chemiluminescent emission and singlet oxygen generation. Meanwhile, the yield of singlet oxygen could be real-time monitored by the ratiometric chemiluminescence and fluorescence imaging to guide cancer chemodynamic therapy.

The development of protocols catalyzed by main group element compounds is desirable to substitute rare and toxic transition metal catalysts. In this issue of Chem, Melen and co-workers employ B(C6F5) as a catalyst for the reaction of α-aryl-α-diazoesters with different heterocycles giving high selectivities and yields in a variety of transformations.

Chemically activated molecular motors that can undergo a full 360° rotation are rare. Designing such an artificial motor while preserving full directional fidelity is even more challenging. In this issue of Chem, Feringa and co-workers demonstrate that this feat can be accomplished through careful molecular design that takes advantage of point and helical chirality, combined with the dynamic nature

In this issue of Chem, Flood and co-workers demonstrate spatially and electronically isolated cationic dyes in crystalline charge-by-charge ion-pairing systems based on sandwiched [2 + 1]-type anion complexes of a π-electronic cyanostar macrocycle; these dyes exhibit fluorescent colors and intensities similar to those in solution.

Metal-free carbon electrocatalysts, such as heteroatom and defective doped carbons, are important for various reactions, including oxygen reduction reaction (ORR) and hydrogen evolution reaction (HER). In this issue of Chem, Yao and co-workers report a targeted synthesis approach to specific carbon defects, including adjacent carbon pentagons and divacancy defects attractive for ORR and HER, respectively

Achieving high selectivity through multiple C–H functionalization is a challenging task. In this issue of Chem, Lumb, Luan, and co-workers disclose a clever strategy taking advantage of steric remote effects for the synthesis of poly-substituted arenes through a 4-component Catellani reaction with remarkable regio- and chemoselectivity by using readily available reagents.

Highly efficient access to both enantiomers of chiral molecules is a long-standing challenge in synthetic chemistry. In a recent paper published in Nature Chemistry, Shu-Li You and coworkers reported a time-dependent enantiodivergent synthesis of chiral amines through an iridium-catalyzed allylic substitution reaction involving two kinetic resolutions.

Bioorthogonal nanofactories have emerged in the last decade to provide xenobiotic pathways that generate nonbiological substances in living environments. In this issue of Chem, Qu and co-workers incorporate asymmetric catalytic properties and chemotactic capabilities into novel nanodevices to achieve the stereo- and site-selective synthesis of the active enantiomer of ibuprofen at inflammation sites

Catalytic and enantioselective ring-closing C(sp3)‒H amidation of urea derivatives has been unexplored. In this issue of Chem, Meggers and co-workers address this challenge by using a chiral-at-ruthenium catalyst to obtain cyclic 2-imidazolidinones in a highly enantioselective manner. The latter can be converted to chiral vicinal diamines without appreciable loss of enantiopurity.

Uranium extraction from seawater (UES) is critical for the sustainable development of nuclear energy but faces tremendous scientific and technical challenges. In this issue of Chem, Zhu and colleagues propose an advanced UES strategy incorporating an extended electric field that can facilitate the migration of uranium species in the channels of sorption materials, leading to record-breaking kinetics