Dr. Adam D. Moorhouse obtained his PhD at the University of Nottingham, UK. In the Moses group, he specializes in click chemistry to advance drug discovery processes. Dr. Joshua A. Homer completed his PhD at the University of Auckland, New Zealand. As a Research Investigator in the Moses group, he applies click chemistry to develop new antibiotics. Dr. John E. Moses is the founding professor of click

Tim Cernak is an associate professor of Medicinal Chemistry at the University of Michigan. He holds appointments in the University of Michigan Department of Chemistry, Program in Chemical Biology, Center for Global Health Equity, and Michigan Institute for Data Science. Tim’s research interests include chemical synthesis, catalysis, total synthesis, cheminformatics, ecology, data science, automation

Melanie Guillén-Soler received her MS degree in organic chemistry in 2018 from Universidad Autónoma de Madrid (UAM) and her PhD in chemistry from Universidade de Santiago de Compostela (2023, USC), where she worked on the development of novel electrocatalyst materials for advanced energy-conversion technologies. Currently, she is a postdoctoral researcher in the Cronin group, working on automation

In this issue of Chem, Yamaguchi and coworkers introduce an exciting strategy for the deacylative cross-coupling of aromatic ketones. Aromatic ketones are first converted into aromatic esters via sequential Claisen and regioselective retro-Claisen condensation. The esters then undergo transition-metal-catalyzed decarbonylative cross-coupling reactions with various nucleophiles affording C–C and C–heteroatom

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Isoprenoid modifications of proteins and peptides serve fundamental biological functions and are of therapeutic interest. While C15 (farnesyl) and C20 (geranylgeranyl) moieties are prevalent among proteins, known ribosomal peptide prenylations involve shorter-chain units not exceeding farnesyl in size. To our knowledge, cyclized terpene moieties have not been reported from either biomolecule class

In this issue of Chem, Chen, Zhang, and coworkers reported an unprecedented ground-state, kinetically trapped, photoinduced charge-transfer complex between an electron-deficient 1,8-naphthalimide acceptor and an electron-rich amine donor. This complex not only has fundamental physical implications in electron donor-acceptor interactions but may also address several challenges in redox-triggered polymerization

Download: Download high-res image (379KB) Download: Download full-size image Dr. Rui Tang obtained her BSc degree in chemistry/chemical technology from a joint program between Sun Yat-Sen University and the Hong Kong Polytechnic University. She then got a MRes degree with distinction in catalysis from Imperial College London. After that, she was admitted to the joint PhD program offered by the University

Lithium sulfide nano-powder material holds great promise as a cathode material and prelithiation agent due to its high theoretical capacity and as an indispensable precursor for sulfide solid electrolytes. However, its industrial application is greatly impeded by problems of low purity, large particle size, and high cost. Here, we evaluate the feasibility and commercial potential of various synthetic

In this issue of Chem, Che et al. report a dinuclear copper(I) complex as an air-stable, efficient photocatalyst for C–C coupling reactions with unact…

Coulomb repulsion in multiply charged ions (MCIs) is mitigated by long-range electrostatic interaction with the distant charge separation and delocalized systems. Meanwhile, MCIs featuring the charged centers located at two directly connected atoms (E+/−–E+/−) bear a strong repulsive force, which leads to electron detachment or molecular fragmentation, namely, Coulomb explosion. Here, we describe the

Synthesis of complex glycans is extremely challenging. In the current issue of Device, Seeberger and co-workers introduce a new oligosaccharide synthesizer. The introduced technology integrates innovative solutions to overcome difficulties associated with solid-phase oligosaccharide synthesis. The focus on an energy efficient, smaller, and user-friendly device forecasts exciting advances in glycochemistry

The development of electric aviation is limited by the need for high-power and high-capacity Li batteries. Recently, in Joule, Helms and co-workers report an omics-enabled approach to the discovery of advanced electrolytes, particularly for batteries in electric aircraft applications.

The relationship between the whole and its parts has been a subject of philosophical proposition for centuries, with reductionism and holism offering divergent perspectives. Recently, through a case study by B.Z. Tang and colleagues published in Matter, aggregate science was coined as a feasible approach to understanding the relationship between the whole and its parts.

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Download: Download high-res image (362KB) Download: Download full-size imageRobert Mayer studied chemistry at Ludwig-Maximilians-Universität in Munich, where he subsequently pursued PhD studies in physical-organic chemistry in the group of Prof. Herbert Mayr and Dr. Armin Ofial. In 2021, he joined the lab of Prof. Joseph Moran as a postdoctoral researcher, investigating nonenzymatic pathways of amino

The improvement in performances of single-molecule magnets (SMMs) is of significant importance. In this issue of Chem, Murugesu and co-workers demonstrate the rational design of new genuine SMMs by coupling lanthanide ions with radical ligands. Their work demonstrates enhanced lanthanide/radical exchange coupling conducting to an impressive giant coercive field in an SMM.

Professor Heather J. Kulik is a professor in chemical engineering and chemistry at MIT. She received her BE in chemical engineering from the Cooper Union in 2004 and her PhD from the Department of Materials Science and Engineering at MIT in 2009. She completed postdocs at Lawrence Livermore and Stanford prior to joining MIT as a faculty member in 2013. Her research in computational inorganic chemistry

Santiago Cañellas is currently leading the Parallel Medicinal Chemistry team at J&J Innovative Medicines, Toledo (Spain). Embedded in Therapeutics Discovery, his team focuses on accelerating the progression of medicinal chemistry programs through the application of AI/ML-driven library design and automated high-throughput chemical synthesis. Prior to joining J&J Innovative Medicines, he performed his

Andrew McGrath completed his PhD studies at the University of Michigan with Tim Cernak, studying amine-acid coupling reactions and their application in medicinal chemistry. Andrew was an undergraduate of the University of Colorado at Colorado Springs and is currently a postdoctoral researcher at Merck & Co., Inc. in Rahway, NJ. Haiyan Huang is currently a postdoctoral fellow in the Cernak Lab at the

Evan Ferry is a graduate student in the Elkin Group. He studied chemistry and philosophy at the University of Michigan, where he researched carbonyl-olefin metathesis with Prof. Corinna Schindler. Masha Elkin is the D. Reid (1941) and Barbara J. Weedon Career Development Assistant Professor of Chemistry at MIT. She completed her BA in chemistry with Prof. Vladimir Birman (Washington University in St