The objective of this study is to elucidate how Royal jelly (RJ) and 10‐hydroxy‐2‐decanoic acid (10‐HDA) prevents diabetic skin dysfunction by modulating the pyroptosis pathway. Type 2 diabetes models are induced by fat diet consumption and low dose of streptozotocin (STZ) in C57BL/6J mice and treated with RJ (100 mg kg–1 day–1) and 10‐HDA, the major lipid component of royal jelly (100 mg kg−1 day−1)

ScopeThis research examines the effects of maternal high‐fat (HF) diet and gestational diabetes mellitus (GDM) on offspring lipid metabolism and polyunsaturated fatty acids (PUFA) profile.Methods and resultsGDM is induced using the insulin receptor antagonist S961. Weaning offspring are categorized into HF‐GDM, HF‐CON, NC‐GDM, and NC‐CON groups based on maternal diet or GDM. Adult offspring are then

ScopeGarlic extract (GE) has been shown to ameliorate hyperglycemia in diabetic rats (DRs) by increasing insulin production. However, the mechanism through which it exerts its effects remains unclear. Here, it investigates the molecular process and the origin of regenerating β‐cell in rats with streptozotocin (STZ)‐induced diabetes in response to GE.Methods and resultsIn this study, quantitative RT‐PCR

ScopeNeutrophils play a decisive role during the immediate defense against infections. However, as observed during rheumatoid arthritis, activated neutrophils can also cause tissue damage. Previous studies indicate that zinc supplementation may alter certain neutrophil functions. However, precise underlying mechanisms and possible effects of zinc deficiency remain incompletely understood. The objective