Urolithin A and B are gut metabolites of ellagic acid and ellagitannins associated with many beneficial effects. Evidence in vitro pointed to their potential as estrogenic modulators. However, both molecular mechanisms and biological targets involved in such activity are still poorly characterized, preventing a comprehensive understanding of their bioactivity in living organisms. This study aimed at

Scope: Previous studies have identified potent anticancer activities of polyphenols in preventing prostate cancer. The aim of the current study was to evaluate the chemopreventive potential of grape powder (GP) supplemented diets in genetically predisposed and obesity‐provoked prostate cancer.

Scope : Antibiotics in early life disrupt microbiota and increase obesity risk, whereas dietary agents such as prebiotics may reduce obesity risk. We examined how antibiotics administered with/without prebiotic oligofructose, alter metabolic and microbial outcomes in pregnant rats and their offspring.

Scope : Trace element (TE) deficiencies often occur accumulated, as nutritional intake is inadequate not for one but several TEs, concurrently. Therefore, we studied the impact of a suboptimal supply of Fe, Zn, Cu, I, and Se on the TE status, health parameters, epigenetics, and genomic stability in mice.

Cholesterol homeostasis is crucial for brain functioning. Unhealthy nutrition can influence cerebral physiology, but the effect of western diets on brain cholesterol homeostasis, particularly at middle age, is unknown. Given the link between brain cholesterol alteration and beta amyloid production, our aim was to evaluate whether a short‐term diet, rich in fat and fructose, affects the protein network

Non‐Alcoholic fatty liver disease (NAFLD) is the most common form of liver disease and is characterized by fat accumulation in the liver. Hypercaloric diets generally increase hepatic fat accumulation, whereas hypocaloric diets decrease liver fat content. In addition, there is evidence to suggest that moderate amounts of unsaturated fatty acids seems to be protective for the development of a fatty

Antonio J. Meléndez‐Martínez Mol. Nutr. Food Res . 2019, 63 , 1801045, https://doi.org/10.1002/mnfr.201801045 In section 3.1.4 of the initially published article (Safety and Toxicity of Carotenoids and Their Derivatives), the unit given for safe additive levels (mg kg−1) is incorrect: Although no ADIs have been established for mixed carotenes and/or β‐carotene, their consumption as additives at levels

IL‐1RI‐mediated inflammatory signaling alters metabolic tissue responses to dietary challenges (e.g. high‐fat diet (HFD)). Recent work suggests that metabolic phenotype is transferrable between mice in a shared living environment (i.e. co‐housing) due to gut microbiome exchange. We examined whether the metabolic phenotype of IL‐1RI−/‐ mice fed HFD or low‐fat diet (LFD) could be transferred to wildtype

Mol. Nutr. Food Res. 2019, 63, 1800975 https://doi.org/10.1002/mnfr.201800975 In the initially published article, the representative images of the +hesperidin (40 mg/kg) group in the bottom panel of Figure 3B and the images of the control group in the first panel are mistakenly identical. Figure 3B is corrected to the following: This error does not affect the results or conclusions of the manuscript