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Light Promoted Vinylogous Arbuzov Reaction with Electron Deficient Alkyl Halides Org. Lett. (IF 5.0) Pub Date : 2025-06-22 Vladislav S. Kostromitin, Vyacheslav I. Supranovich, Alexander D. Dilman
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Copper(I)-Catalyzed Synthesis of 1-Amino-1,3-diene Derivatives through a Formal 1,3-Amino Migration Process Org. Lett. (IF 5.0) Pub Date : 2025-06-22 Junwei Li, Shuangshuang Liu, Tiantian Zhang, Liliang Huang, Huangdi Feng
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Chemodivergent Sulfenylation of Trifluoromethylalkenes: Controlled Synthesis of Fluorinated 1,3-Dithioethers and β-Trifluoromethyl Thioethers Org. Lett. (IF 5.0) Pub Date : 2025-06-21 Min-Zhao Huang, Lin-Xi Xiao, Xing-Guo Zhang, Xiao-Fang Song, Hai-Yong Tu
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Substituent Effects on NMR Chemical Shifts and Cyclic Hydrogen Bonding in 2-Pyridone Dimers: An Accurate Approach to Hammett Constant Determination Linking Structure, Energetics, and Electron Distribution J. Org. Chem. (IF 3.3) Pub Date : 2025-06-21 Mambatta Haritha, Sherin S. Ameena, Cherumuttathu H. Suresh
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Diastereoselective Synthesis of Silyl-Substituted Pyrrolidines J. Org. Chem. (IF 3.3) Pub Date : 2025-06-21 Davide Carboni, Giulio Casagranda, Simone Di Remigio, Alice Mirone, Arianna Quintavalla, Marco Lombardo
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Solution-Phase Synthesis of Boranophosphate and Boranophosphate/Phosphorothioate/Phosphate Chimeric Oligonucleotides via the H-Boranophosphonate Method J. Org. Chem. (IF 3.3) Pub Date : 2025-06-20 Yuhei Takahashi, Itsuki Kato, Kazuki Sato, Takeshi Wada
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Synthesis and Base-Pairing Properties of Oligonucleotides Containing 5′-(R)- and 5′-(S)-C-Aryl-thymidine J. Org. Chem. (IF 3.3) Pub Date : 2025-06-20 Marcel Hausdorff, Arie Van der Lee, Mary Anne Maverick, Jean-Jacques Vasseur, Françoise Debart, Michael Smietana
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Visible-Light-Induced Aerobic ortho-Selective C–H Hydroxylation of Benzils J. Org. Chem. (IF 3.3) Pub Date : 2025-06-20 Jiaoyue Lv, Huiying Zeng
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Harnessing Radicals for the Selenotrifluoromethylation within a Confined Metal–Organic Framework Org. Lett. (IF 4.9) Pub Date : 2025-06-21 Cong Zhao, Xianzhi Lan, Jiabin Chen, Yajun Zhao, Guangqing Wang, Ya Li, Jiewei Liu, Yan-Zhong Fan, Lu Chen
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Visible Light-Promoted Construction of Cage-Like Frameworks by Sequential [2 + 2] Cycloaddition Org. Lett. (IF 4.9) Pub Date : 2025-06-21 Zhuhai Zhang, Yu Feng, Jianfu Chen, Xiangqian Liu, Martin D. Smith, Kang Du, Wenjun Tang
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Electrochemical Functionalization of Alkenes with 1,3-Dicarbonyl Compounds via Radical Addition Org. Lett. (IF 4.9) Pub Date : 2025-06-20 Rakesh Kumar, Nakshatra Banerjee, Suman Pal, Umesh Godara, Prabal Banerjee
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Photoelectrochemical Iron–Nickel Synergistic Catalysis for C(sp3)-H and Dehydroxymethylative Acylation Org. Lett. (IF 4.9) Pub Date : 2025-06-20 Xiao Zhou, Ping-Fu Zhong, Zhuohua Li, Pengwei Hu, Jialin Tu, Chao Yang, Lin Guo, Wujiong Xia, Tingting Chen
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Synthesis of 1,2-Oxaborole via Base-Mediated Borylation of Propynols Org. Chem. Front. (IF 4.6) Pub Date : 2025-06-21 Sumit Ghosh, Sudip Laru, Mukta Singsardar, Alakananda Hajra
Boron-containing derivatives have numerous applications in medicinal-, industrial- and synthetic chemistry. Considering it, a new mild, catalyst-free, additive-free, base-assisted one-step robust method has been reported for the efficient synthesis of valuable 1,2-oxaborole derivatives via borylation of propynols using only cesium carbonate as a mild base. The reaction proceeds under mild conditions
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Gram-Scale Synthesis of Dibenzo[a,e]pentalenes from Trialkyl(phenylethynyl)silanes via Organosodium Intermediates J. Org. Chem. (IF 3.3) Pub Date : 2025-06-20 Ayane Sato, Takuya Kuwabara
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The Mechanism of the Rappe Rearrangement─A Stereochemical Investigation Using Density Functional Theory J. Org. Chem. (IF 3.3) Pub Date : 2025-06-20 Toby J. Sommer, Henry S. Rzepa
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Boron-Containing Chiral Spiro Molecules: Synthesis and Color-Tunable Circularly Polarized Luminescence J. Org. Chem. (IF 3.3) Pub Date : 2025-06-20 Masahiro Ikeshita, Miku Ichinose, Jungo Ono, Daiya Suzuki, Yoshitane Imai, Takashi Tsuno
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Mechanistic Studies of Pd-Catalyzed β- and γ-C(sp3)–H Arylations and the Computational Design of Bidentate Pyridone Ligands J. Org. Chem. (IF 3.3) Pub Date : 2025-06-19 Yue Qiao, Miaomiao Xu, Wei Li, Ya Hu, Jiying Xu, Lei Qin, Kai Guo, Lili Zhao
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The Fluorinative Skeletal Rearrangement of Lumisantonin: An Unanticipated Dual Role of Selectfluor J. Org. Chem. (IF 3.3) Pub Date : 2025-06-19 Ferdinand Woge, Muyuan Wang, Brandon White, Neil Kiame, Maxime A. Siegler, Travis Dudding, Cody Ross Pitts, Thomas Lectka
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Migrative Reductive Amination of Ketones Enabled by Multitasking Reagents J. Org. Chem. (IF 3.3) Pub Date : 2025-06-19 Artem Khegay, Dennis G. Hall
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Stereocontrolled First Generation Synthesis of RIPK1 Inhibitor GDC-8264 Org. Process Res. Dev. (IF 3.1) Pub Date : 2025-06-20 Allen Y. Hong, Nicholas Wong, Sean M. Kelly, Lauren E. Sirois, Sara Schwegler, Xin Linghu, Carmela Molinaro, C. Gregory Sowell, Francis Gosselin
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Stereoselective Synthesis of Tetrasubstituted Alkenes from 1,2-Diketones via Oxyphosphonium Salts-Engaged Suzuki–Miyaura Coupling Org. Lett. (IF 4.9) Pub Date : 2025-06-20 Bin Zhang, Jinyan Wan, Chuan Zhu, Chao Feng
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Hyper-Cross-Linked Polymer Bearing a Functional Ligand-Supported Iridium Complex: A Recyclable Metal–Polymer Ligand Bifunctional Catalyst for the N-Trideuteromethylation of Amines with Deuterated Methanol Org. Lett. (IF 4.9) Pub Date : 2025-06-20 Xiaozhong Chen, Lu Shen, Yuexin Ji, Junjie Min, Yuran Fan, Feng Li
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A Visible Light Promoted Regioselective Cascade Radical Trifluoromethylation/Cyclization of N-Isopentenyl Aldehyde Hydrazones: Access to Trifluoromethylated Tetrahydropyridazine Derivatives Org. Lett. (IF 4.9) Pub Date : 2025-06-19 Yuanyuan Ren, Yuxiu Zhou, Ke-Hu Wang, Junjiao Wang, Danfeng Huang, Yulai Hu
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Radical 1,4-acylcyanoalkylation of alkenes for the synthesis of ζ-ketonitriles Org. Chem. Front. (IF 4.6) Pub Date : 2025-06-20 Ying Tong, Jia-Yao Feng, Cuiyan Wu, Shi-Qing Zhang, Ming-Qi Yang, Sheng Du, Dong-Qing Yang, Keqi Tang, Chao Deng, Wenting Wei
Two-component alkenes coupling reactions serve as an efficient platform for the synthesis of complex molecular architectures. Herein, leveraging the differences in activation energy barriers among carbon radical precursors and the polarity matching between radicals, this work pioneers the first example of radical 1,4-acylcyanoalkylation to synthesize challenging-to-access ζ-ketonitriles using two identical
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Radical di- and multi-functionalization of alkenes: Recent advances in diverse reaction modes utilizing TBHP as reactants Org. Chem. Front. (IF 4.6) Pub Date : 2025-06-20 Jiantao Zhang, Renhua Su, Weibing Liu
In recent years, radical-mediated functionalization of olefins has gradually become a research hotspot in the field of organic synthesis due to its high reactivity, excellent regioselectivity, and wide substrate applicability. Compared to traditional ionic pathways, radical strategies effectively avoid compatibility issues with some functional groups through modes such as photocatalysis, electrocatalysis
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Cu/chiral phosphoric acid-catalyzed asymmetric (3+2) cycloaddition of donor-acceptor aziridines with aldehydes: synthesis of enantioenriched oxazolidines as potential antitumor agents Org. Chem. Front. (IF 4.6) Pub Date : 2025-06-20 Zhichao Shi, Tingting Fan, Jin-Shun Lin, Weibin Xie, Feng Zhan, Zhe Wang, Qinglu Zuo, Haoran Fu, Xun Zhang, Qiuhua Huang, Yuyang Jiang
Chiral oxazolidines are pivotal structural motifs commonly found in natural products, medicinally important compounds, and chiral ligands. Among various synthetic strategies, the asymmetric formal (3+2) annulation of donor–acceptor (D–A) aziridines with dipolarophiles has emerged as a powerful method for constructing enantioenriched five-membered azaheterocycles with potential bioactivity. Herein,
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NHC‐based Photoswitches in Catalysis: Recent Developments and Challenges Eur. J. Org. Chem. (IF 2.7) Pub Date : 2025-06-20 Gilles Alcaraz, Lucie Jarrige
Using light as an external stimulus, photoswitchable catalysis offers the attractive opportunities to modulate the activity and selectivity of catalytic systems on demand and remotely, with high spatial and temporal precision. Consequently, the development of photoswitchable catalyst has attracted considerable attention from the chemist community in recent decades, leading to various photoresponsive
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Eco‐Friendly Borylation of Allylic Acetates via Nickel‐Catalyzed Dual‐Role Base Activation Eur. J. Org. Chem. (IF 2.7) Pub Date : 2025-06-20 Ziyi Quan, Yaxu Liu, Aihua Zhen, Fengcui Ma, Xiang Gao, Jifu Sun, Bo Wang
Allylic boronates are valuable synthons in organic chemistry, making the development of efficient and sustainable preparation methods highly desirable. We report a nickel‐catalyzed borylation of unactivated allylic acetates using a recyclable N‐donor ligand system in ethyl acetate. The method employs an innovative dual‐role base that simultaneously activates diboron reagents and reduces air‐stable
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Exploring the Impact of Topological Variations on the Stability of the Ground Singlet and Lowest‐Lying Triplet States of Catacondensed Hexabenzenoids Eur. J. Org. Chem. (IF 2.7) Pub Date : 2025-06-20 Iqra Sarfraz, Anna Roglans, Albert Artigas, Miquel Solà
Polycyclic aromatic hydrocarbons (PAH) like tetracenes, pentacenes, hexacenes, and some higher acenes play a central role in organic electronics due to their unique electronic properties. The impact of topological variations on the relative stability of PAH isomers in different electronic states is poorly understood, with limited insights into how Clar p‐sextets and topological features like bay, cove
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Regioselective Synthesis of (E)-3-((Alkylamino)methylene)-2-thioxothiochroman-4-one Derivatives and Their Regioselective Cycloaddition with Alkynes J. Org. Chem. (IF 3.3) Pub Date : 2025-06-19 Ahmad Ali, Sikhamoni Begam, Kriti Mehta, Prasad V. Bharatam, Abu Taleb Khan
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Solventless Catalytic C–H and C–X Functionalization without Ball Milling J. Org. Chem. (IF 3.3) Pub Date : 2025-06-18 Carolina Méndez-Gálvez, Fredrik Barnå, Boris Olsthoorn, David Estébanez Rosich, Paul J. Gates, Lukasz T. Pilarski
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Nickel-Catalyzed Hydrocarboxylation of Styrenes with Carbon Dioxide and Water J. Org. Chem. (IF 3.3) Pub Date : 2025-06-18 Ruoxi Yu, Lingyun Huang, Haoyu Zhang, Yuegang Chen
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I2/PIDA Mediated Regioselective Metal-Free Synthesis of Aryl Selenoether-Linked Trisubstituted Thiazoles J. Org. Chem. (IF 3.3) Pub Date : 2025-06-18 Danish Ali, Nurabul Mondal, Lokman H. Choudhury
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Synthetic Study of Kosinostatin Aglycon: Synthesis of the ABCDEFG Ring Skeleton J. Org. Chem. (IF 3.3) Pub Date : 2025-06-18 Yutaro Shimizu, Shuhei Takahashi, Takumi Iwata, Hirokazu Shimooka, Tatsuo Okauchi, Mitsuru Kitamura
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Sulfur-Rich Hole-Transporting Materials for Inverted Perovskite Solar Cells Org. Lett. (IF 4.9) Pub Date : 2025-06-19 Yogesh S. Tingare, Lin-Yi Liu, Chaochin Su, Wen-Zheng Lin, Chen-Yi Yen, Wei-Hong Chen, Sheng-Hung Teng, Mei-Jie Chen, Chen-Wei Chu, Wen-Ren Li
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Direct and Site-Selective C–H Cyanation of (Hetero)arenes by a Nontoxic Cyano Source Org. Lett. (IF 4.9) Pub Date : 2025-06-19 Ao Xu, Song-Lin Zhang
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Anion-Mediated Synthesis of Diethynyl-Substituted Doubly N-Confused Dioxohexaphyrin Dyes That Exhibit Enhanced Photoacoustic Signals in the NIR-II Region Org. Lett. (IF 4.9) Pub Date : 2025-06-19 Hiroto Kai, Yuma Nakamura, Kotaro Kai, Sandipa Bhandari, Yusuke Notsuka, Shigeki Mori, Tatsuki Abe, Daisuke Kawaguchi, Yoshihisa Yamaoka, Hiroyuki Furuta, Masatoshi Ishida
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Photocatalyzed 18F-Fluorination: A Streamlined Radiolabeling Approach for Rapid Adoption and Automation Org. Lett. (IF 4.9) Pub Date : 2025-06-19 Yueqi Wang, Lili Pan, Kai Lu, Mingxing Hu, Cheng Zheng, Mufeng Li, Yang Xie, Cheng Yang, Hongbao Sun, Xiaoai Wu, Haoxing Wu, Wei Chen
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Ternary Synthon Strategy for 1,3,5-Trisubstituted Benzenes via [3 + 3] Benzannulation of Propargyl Alcohols Org. Lett. (IF 4.9) Pub Date : 2025-06-18 Liu-Bin Li, Cai Zhai, Cuiyan Wu, Wei-Qian Fan, Chen Li, Yi-Bin Zhang, Hong-Lin Wu, Chen Zhu, Wen-Ting Wei
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π-Truncation of a Parent Nanographene: Chirally Twisted Green Fluorophores Org. Lett. (IF 4.9) Pub Date : 2025-06-18 He Meng, Tianyu Zhang, Zhenxun Xu, Shuqin Han, Huricha Baigude, Yoshifumi Hashikawa, Chaolumen
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Polyene Cyclization/Mannich Cascade for Streamlined Construction of the A/E/F Tricyclic System of Diterpenoid Alkaloids Org. Lett. (IF 4.9) Pub Date : 2025-06-18 Yueshen Feng, Shuping Li, Minhang Chang, Lu Zhang, Ding Li, Jin-Ming Gao, Zhigang Liu
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Palladium(0)-Catalyzed Asymmetric Cross Inverse-Electron-Demand Diels–Alder Reaction between Distinct Electron-Deficient Dienes Org. Lett. (IF 4.9) Pub Date : 2025-06-18 Ke Xie, Bao-Rui Kong, Chuang-Qi Wang, Zhi-Chao Chen, Wei Du, Ying-Chun Chen
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Stereospecific Oxidative Contraction of Anomeric Nucleophiles Org. Lett. (IF 4.9) Pub Date : 2025-06-18 Santosh Shelar, Nicholas Ryan, Timothy Davis, Maciej A. Walczak
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Correction to “Merging Paired Electrolysis and Copper Catalysis Enables Electrochemical Arylation of Aziridine for the Synthesis of 1,2-Amino Tertiary Alcohols” Org. Lett. (IF 4.9) Pub Date : 2025-06-18 Zhong-Shan Teng, Yu-Rong Yang, Xin-Yu Zhang, De-Xin Xie, Li-Li Liao, Cheng-He Zhou, Gui-Xin Cai, Zhong-Lin Zang
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Rhodaelectro-catalyzed C–H activations directed by pharmacophores: enabling modification of bioactive compounds Org. Chem. Front. (IF 4.6) Pub Date : 2025-06-19 Shangyong Wu, Binbin Yuan, Yongke Lei, Xiaoli Su, Tristan von Münchow, João C. A. Oliveira, Xuewu Huang, Zhaojun Ding, Rongrong Xu, Lutz Ackermann, Jiayu Mo
In the realm of sustainable molecular synthesis, metallaelectro-catalysis has emerged as a highly potent platform over the past decade. While significant advancements have been achieved in this field, the development of strategies for late-stage C–H functionalization remains a formidable challenge. In this context, we present an electrochemical rhodium-catalyzed C–H activation strategy that facilitates
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A Multicomponent aza‐Prins Strategy for the Diastereoselective Synthesis of Piperidine Fused Dihydroquinazolinones Eur. J. Org. Chem. (IF 2.7) Pub Date : 2025-06-19 Lovisa Dybeck, Morgane Baudoin, Luke Robert Odell
Dihydroquinazolinones and piperidines are widely acknowledged as privileged structures and are of significant interest for the development of new drug candidates. Herein we present a novel aza‐Prins strategy for the synthesis of piperidine fused dihydroquinazolinones through a domino multicomponent reaction. Homoallylic ammonium halide salts were found to react with bifunctional aldehydes under acidic
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Quinoliporphyrin as an Aromatic Monoanionic Porphyrinoid and Its Degradation Promoted by Cu2+ J. Org. Chem. (IF 3.3) Pub Date : 2025-06-18 Yoon Hee Lee, Sung-Wook Choi, Min-Sung Ko, Tae-Ho Roh, Dong-Gyu Cho
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Photocatalytic Redox-Neutral Alkoxysulfonylation of Alkenes J. Org. Chem. (IF 3.3) Pub Date : 2025-06-18 Jie Gong, Fang Wang, Yan-Biao Kang, Jian-Ping Qu
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Triplet Ketone Catalysis-Enabled Functionalization of Thioanisoles with Maleimides J. Org. Chem. (IF 3.3) Pub Date : 2025-06-18 Akash Bisoyi, Ramsiya Poolamanna, Alisha Rani Tripathy, Veera Reddy Yatham
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Visible-Light-Driven Photocatalytic Synthesis of Polysubstituted Pyrrolidines via Desulfurative Tandem Cyclization of Thiols with 1,6-Enynes J. Org. Chem. (IF 3.3) Pub Date : 2025-06-18 Hongda Xia, Hengming Yang, Jiangna Yue, Chongchong Ma, Xia Fan, Rongshun Chen
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N-Amidopyridinium Salts as N-Radical Precursors for the Visible-Light-Promoted Radical Cascade Cyclization: Access to Amidated Phenanthridines J. Org. Chem. (IF 3.3) Pub Date : 2025-06-18 Xia Mi, Qiannan Tan, He Chen, Chao Pi
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TBHP/I2 Synergistically Promoted Three-Component Reaction of Isatins, Amines and Methylhetarenes: Transition-Metal-Free Access to 2-Hetarylquinazolin-4(3H)-ones J. Org. Chem. (IF 3.3) Pub Date : 2025-06-18 Cheng Xu, Tao Peng, Minglin Liu, Mengyuan Zhou, Qianqian Zhai, Yifei Wang, Yuan Chen, Zheng Liu, Guodong Yin
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Tandem Synthesis of Tetrahydropyrroloquinazolines and Related Polyannular Scaffolds J. Org. Chem. (IF 3.3) Pub Date : 2025-06-18 Haley M. Carlson, R. Adam Mosey
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Direct, Asymmetric, and Stereodivergent Reactions of N-Azidoacetyl Thioimides with Aromatic Acetals Catalyzed by Chiral Nickel(II) Complexes. An Approach to the Synthesis of syn- and anti-β-Alkoxy-α-amino Acids J. Org. Chem. (IF 3.3) Pub Date : 2025-06-17 Miguel Mellado-Hidalgo, Joan Conejos-Jalencas, Saúl F. Teloxa, Andrea Suárez-Herrera, Luke McCall, Anna M. Costa, Pedro Romea, Fèlix Urpí, Gabriel Aullón, Cristina Puigjaner
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Regioselective and Chemodivergent Synthesis of 1,3-Indandione-Fused Spirocyclopentenes and Spiropyrrolidines J. Org. Chem. (IF 3.3) Pub Date : 2025-06-17 Nabin Parui, Pratap Paul, Sk Jubayar Ahashan, Jyotirmayee Dash
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Regiodivergent Annulation Reactions of Chalcones to Indenones and Indanones with C1 Reagents J. Org. Chem. (IF 3.3) Pub Date : 2025-06-17 Xinchi Gong, Sunewang R. Wang
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Ligand-Free Silver Fluoride-Promoted (3 + 2) Annulation of Oxaziridines and α-Isocyanoacetates: A Diastereoselective Route to cis-Imidazolines J. Org. Chem. (IF 3.3) Pub Date : 2025-06-17 Jubao Zhou, Siyun Wang, Hu Shi, Hui Jin, Lixin Zhang
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Enhanced Cytotoxicity of 10α,9β-Abiraterone Analogues Synthesized via LED Photocatalysis J. Org. Chem. (IF 3.3) Pub Date : 2025-06-17 Hongping Jiang, Xirong Liu, Chunling Zeng, Jie Tang, Guofang Jiang
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Acid-Enabled Dearomative Umpolung of 3-Indolylquinones toward C3-Oxygenated Benzofuro[2,3-b]indolines J. Org. Chem. (IF 3.3) Pub Date : 2025-06-17 Wenkang Wu, Chenglong Zhu, Yongzheng Zhang, Tingting Yan, Jingyuan Yao, Guanyu Yang, Yingchao Dou
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The Form of the HOMA Geometric Aromaticity Index Is Universal and Allows the Design of Electronic and Magnetic Descriptors J. Org. Chem. (IF 3.3) Pub Date : 2025-06-17 Jan Cz. Dobrowolski, Sławomir Ostrowski