Boron-containing derivatives have numerous applications in medicinal-, industrial- and synthetic chemistry. Considering it, a new mild, catalyst-free, additive-free, base-assisted one-step robust method has been reported for the efficient synthesis of valuable 1,2-oxaborole derivatives via borylation of propynols using only cesium carbonate as a mild base. The reaction proceeds under mild conditions

Two-component alkenes coupling reactions serve as an efficient platform for the synthesis of complex molecular architectures. Herein, leveraging the differences in activation energy barriers among carbon radical precursors and the polarity matching between radicals, this work pioneers the first example of radical 1,4-acylcyanoalkylation to synthesize challenging-to-access ζ-ketonitriles using two identical

In recent years, radical-mediated functionalization of olefins has gradually become a research hotspot in the field of organic synthesis due to its high reactivity, excellent regioselectivity, and wide substrate applicability. Compared to traditional ionic pathways, radical strategies effectively avoid compatibility issues with some functional groups through modes such as photocatalysis, electrocatalysis

Chiral oxazolidines are pivotal structural motifs commonly found in natural products, medicinally important compounds, and chiral ligands. Among various synthetic strategies, the asymmetric formal (3+2) annulation of donor–acceptor (D–A) aziridines with dipolarophiles has emerged as a powerful method for constructing enantioenriched five-membered azaheterocycles with potential bioactivity. Herein,

Using light as an external stimulus, photoswitchable catalysis offers the attractive opportunities to modulate the activity and selectivity of catalytic systems on demand and remotely, with high spatial and temporal precision. Consequently, the development of photoswitchable catalyst has attracted considerable attention from the chemist community in recent decades, leading to various photoresponsive

Allylic boronates are valuable synthons in organic chemistry, making the development of efficient and sustainable preparation methods highly desirable. We report a nickel‐catalyzed borylation of unactivated allylic acetates using a recyclable N‐donor ligand system in ethyl acetate. The method employs an innovative dual‐role base that simultaneously activates diboron reagents and reduces air‐stable

Polycyclic aromatic hydrocarbons (PAH) like tetracenes, pentacenes, hexacenes, and some higher acenes play a central role in organic electronics due to their unique electronic properties. The impact of topological variations on the relative stability of PAH isomers in different electronic states is poorly understood, with limited insights into how Clar p‐sextets and topological features like bay, cove

In the realm of sustainable molecular synthesis, metallaelectro-catalysis has emerged as a highly potent platform over the past decade. While significant advancements have been achieved in this field, the development of strategies for late-stage C–H functionalization remains a formidable challenge. In this context, we present an electrochemical rhodium-catalyzed C–H activation strategy that facilitates

Dihydroquinazolinones and piperidines are widely acknowledged as privileged structures and are of significant interest for the development of new drug candidates. Herein we present a novel aza‐Prins strategy for the synthesis of piperidine fused dihydroquinazolinones through a domino multicomponent reaction. Homoallylic ammonium halide salts were found to react with bifunctional aldehydes under acidic