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Benzoxaborole Catalyst Embedded with a Lewis Base: A Highly Active and Selective Catalyst for cis-1,2-diol Modification J. Org. Chem. (IF 3.6) Pub Date : 2024-04-26 Shuhei Kusano, Yuji Yamada, Shinya Hagihara
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Redox Relay-Induced C–S Radical Cross-Coupling Strategy: Application in Nontraditional Site-Selective Thiocyanation of Quinoxalinones J. Org. Chem. (IF 3.6) Pub Date : 2024-04-26 Shi-Hui Shi, Hao-Yu Li, Hao-Yang Liu, Rui Tian, Hai-Tao Zhu
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Direct Synthesis of Glycosyl Chlorides from Thioglycosides J. Org. Chem. (IF 3.6) Pub Date : 2024-04-26 Daniel J. Hoard, Yogesh Sutar, Alexei V. Demchenko
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Ligand-Free Iron-Catalyzed Construction of C–P Bonds via Phosphorylation of Alcohols: Synthesis of Phosphine Oxides and Phosphine Compounds J. Org. Chem. (IF 3.6) Pub Date : 2024-04-26 Liguang Gan, Changxu Ye, Tianshu Pi, Lingling Wang, Chunya Li, Long Liu, Tianzeng Huang, Tieqiao Chen, Li-Biao Han
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A Recyclable Electrochemical Reduction of Aldehydes and Ketones to Alcohols Using Water as the Hydrogen Source and Solvent J. Org. Chem. (IF 3.6) Pub Date : 2024-04-26 Jiatai Zhang, Meng Chen, Jing Xiao, Hongliang Han, Jianyou Zhao, Lanlan Zhang, Fan Wang, Zhong-Quan Liu
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Synthesis of Functionalized Organosilicon Compounds/Distal Ketones via Ring-Opening Giese Addition of Cycloalkanols under Organophotocatalytic Conditions J. Org. Chem. (IF 3.6) Pub Date : 2024-04-26 Raghunath Chowdhury, Akhil K. Dubey, Rajib Ghosh
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Self-Catalyzed, Visible-Light-Induced Selective C3–H Aroylation of Quinoxalin-2(1H)-ones with Arylaldehydes by Air as an Oxidant J. Org. Chem. (IF 3.6) Pub Date : 2024-04-26 Wenhao Liu, Xingyuan Liu, Runjiao Liu, Hanqing Zhao, Zihao Xia
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Anion Binding to Ammonium and Guanidinium Hosts: Implications for the Reverse Hofmeister Effects Induced by Lysine and Arginine Residues J. Org. Chem. (IF 3.6) Pub Date : 2024-04-25 Jacobs H. Jordan, Corinne L.D. Gibb, Thien Tran, Wei Yao, Austin Rose, Joel T. Mague, Michael W. Easson, Bruce C. Gibb
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Electrochemical Oxidative Sulfonylation–Azidation of Alkenes J. Org. Chem. (IF 3.6) Pub Date : 2024-04-25 Bin Song, Pengxiang Gao, Bingcheng Hu, Chong Zhang
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Process Development of a Macrocyclic Peptide Inhibitor of PD-L1 J. Org. Chem. (IF 3.6) Pub Date : 2024-04-25 Subha Mukherjee, Amanda Rogers, Gardner Creech, Chao Hang, Antonio Ramirez, Michael Dummeldinger, Shawn Brueggemeier, Claudio Mapelli, Serge Zaretsky, Masano Huang, Regina Black, Michael B. Peddicord, Nicolas Cuniere, James Kempson, Joseph Pawluczyk, Martin Allen, Rodney Parsons, Chris Sfouggatakis
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10-Phenylphenothiazine-Organophotocatalyzed Bromo-Perfluoroalkylation of Unactivated Olefins J. Org. Chem. (IF 3.6) Pub Date : 2024-04-25 Koto Tagami, Moeko Nakayama, Tadashi Kanbara, Dominique Cahard, Tomoko Yajima
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Direct Synthesis of α-Ketoamides via Copper-Catalyzed Reductive Amidation of Nitroarenes with α-Oxocarboxylic Acids J. Org. Chem. (IF 3.6) Pub Date : 2024-04-24 Jialing Liu, Jiaxin Yao, Jiahui Du, Lin Yu, Wengui Duan, Yuxuan Xiao, Zhiguo Lei
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Iridium(III)-Catalyzed One-Pot Synthesis of Planar Chiral Emissive Materials through C−H Activation Org. Chem. Front. (IF 5.4) Pub Date : 2024-04-26 Wenjing Liu, Honghan Ji, Wenzeng Duan, Huaiwei Wang, Yanmin Huo, Xianqiang Huang, Pengfei Duan
In this study, we detail the synthesis of a series of 4-aryl-5-carboxy[2.2]paracyclophanes (3a‒3s) through the C(sp2)−H activation of 4-carboxy[2.2]paracyclophane, representing the first instance of such a catalytic procedure. This protocol demonstrates remarkable versatility, accommodating various α-substituted pyridine boronates bearing electron-donating groups, thiophene boronate, and aryl boronates
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Dual Photoredox/Nickel-Catalyzed Mizoroki-Heck Cross-Coupling Reactions Org. Chem. Front. (IF 5.4) Pub Date : 2024-04-26 Jun Dong, Yanfei Hu, Yan Tang, Fen Zhao, Yongyun Zhou, Baomin Fan
A method for the Mizoroki-Heck reaction of electron-deficient olefins acrylates with commercially available aryl bromides to obtaining α-arylation products of acrylates via dual light/nickel catalytic system is described. This transformation features a broad substrate scope, good functional group tolerance, and compatibility with heterocyclic substrates. Mechanistic studies clearly reveal that the
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Palladium/copper-cocatalyzed three-component tandem cyclization of o-alkenyl arylisocyanides, sulfur ylides with alcohols: direct synthesis of spiro 3,3’-cyclopropyl oxindoles Org. Chem. Front. (IF 5.4) Pub Date : 2024-04-26 Yue Gong, Xue-Cen Xu, Zi-Xuan Yang, Yu-Long Zhao
A novel palladium/copper-cocatalyzed three-component tandem cyclization of o-alkenyl arylisocyanides, sulfur ylides with alcohols has been developed for the first time. The reaction provides a simple and efficient method for the direct synthesis of spiro 3,3’-cyclopropyl oxindoles from the easily available acyclic starting materials in a single step. Further applications, including synthesis of spiro
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Synthesis and Study of Steering of Azido-tetrazole Behavior in Tetrazolo[1,5-c]pyrimidin-5-amine-Based Energetic Materials J. Org. Chem. (IF 3.6) Pub Date : 2024-04-25 Saira Manzoor, Muhammad Adnan Younis, Qamar-un-nisa Tariq, Jun-Qing Yang, Naushad Ahmad, Chuntian Qiu, Bingbing Tian, Jian-Guo Zhang
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2-Pyridone-Directed CuII–Catalyzed General Method of C(sp2)-H Activation for C–S, C–Se, and C–N Cross-Coupling: Easy Access to Aryl Thioethers, Selenide Ethers, and Sulfonamides and DFT Study J. Org. Chem. (IF 3.6) Pub Date : 2024-04-25 Tanmay K. Pati, Sabir Ali Molla, Narendra Nath Ghosh, Mrinalkanti Kundu, Sk Ajarul, Pradip Maity, Uttam Khamrai, Dilip K. Maiti
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Bispericyclic Ambimodal Dimerization of Pentafulvene: The Origin of Asynchronicity and Kinetic Selectivity of the Endo Transition State J. Org. Chem. (IF 3.6) Pub Date : 2024-04-25 Rama Krishna Kadiyam, Akanksha Ashok Sangolkar, Mohmmad Faizan, Ravinder Pawar
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A Semiflexible Tetrahydrazone Macrocycle for Binding of Pyrophosphate and Smaller Anions J. Org. Chem. (IF 3.6) Pub Date : 2024-04-25 Lau Halgreen, Aaron Torres-Huerta, Karolis Norvaisa, Gaël De Leener, Nikolay Tumanov, Johan Wouters, Kristin Bartik, Hennie Valkenier
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Design and Synthesis of Indazole–Indole Hybrid via tert-Butyl Nitrite Mediated Cascade Diazotization/Isomerization/Cyclization J. Org. Chem. (IF 3.6) Pub Date : 2024-04-25 Abhishek Kar, Gopal Rana, Rajkamal Sahoo, Sourav Ghosh, Umasish Jana
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Synthesis of Pyrimido[1,2-a]indolediones and Pyrimidinediones via [4+2] Annulation of 2H-Azirine-2-carbaldehydes J. Org. Chem. (IF 3.6) Pub Date : 2024-04-25 Lesong Li, Zhenyu Shi, Congyang Li, Xiaoli Zhang, Yichi Zhang, Weiwu Ren
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Paired Electrolysis-Enabled Arylation of Quinoxalin-2(1H)-ones J. Org. Chem. (IF 3.6) Pub Date : 2024-04-24 Jia-Cheng Hou, Jun Jiang, Yan-Cui Wen, Yan-Yan Zeng, Yu-Han Lu, Jia-Sheng Wang, Li-Juan Ou, Wei-Min He
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Halogen-Bonding-Enabled Photoinduced Atom Transfer Radical Addition/Cyclization Reaction Leading to Tricyclic Heterocycles J. Org. Chem. (IF 3.6) Pub Date : 2024-04-24 Eiji Yamaguchi, Masanobu Murai, Akichika Itoh
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Effects of Ionic Liquids on the Nucleofugality of Bromide J. Org. Chem. (IF 3.6) Pub Date : 2024-04-24 Andrew Y. Hsieh, Ronald S. Haines, Jason B. Harper
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Electrochemical Synthesis of a Sitagliptin Precursor J. Org. Chem. (IF 3.6) Pub Date : 2024-04-24 Elisabeth K. Oehl, Paul T. Jirsch, Jasmin Hammes, Andreas Stenglein, María Méndez, Sven Ruf, Siegfried R. Waldvogel
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Synthesis of Canthin-4-ones and Isocanthin-4-ones via B Ring Construction J. Org. Chem. (IF 3.6) Pub Date : 2024-04-24 Maria Koyioni, Andreas Kourtellaris, Panayiotis A. Koutentis
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Acetate Assistance in Regioselective Hydroamination of Allenamides: A Combined Experimental and Density Functional Theory Study J. Org. Chem. (IF 3.6) Pub Date : 2024-04-23 Tapas R. Pradhan, Abdikani Omar Farah, Kadiyala Sagar, Henry R. Wise, Malempati Srimannarayana, Paul Ha-Yeon Cheong, Jin Kyoon Park
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Synthetic Approach toward Diverse Oxa-Cages via Olefin Metathesis J. Org. Chem. (IF 3.6) Pub Date : 2024-04-23 Sambasivarao Kotha, Gulazarahind Mehta, Kunkumita Jena
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Synthesis, Characterization, and Properties of Heat-Resistant Energetic Materials Based on C–C Bridged Dinitropyrazole Energetic Materials J. Org. Chem. (IF 3.6) Pub Date : 2024-04-23 Rongzheng Zhang, Yuangang Xu, Feng Yang, Shuaijie Jiang, Pengcheng Wang, Qiuhan Lin, Hui Huang, Ming Lu
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TEMPO-Mediated Dehydrogenative Hydroxyfluoroalkylation of Arylamines with Polyfluorinated Alcohols J. Org. Chem. (IF 3.6) Pub Date : 2024-04-23 Xiaoyang Gao, Juting Liao, Hengyi Wei, Ye Xu, Ruirui Zhai, Dulin Kong, Shuojin Wang, Xun Chen
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Electrochemical Formation of α-Ketoamides from Ketoximes through Non-Beckmann Mechanism Pathway J. Org. Chem. (IF 3.6) Pub Date : 2024-04-23 Issa Yavari, Sina Shaabanzadeh
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Synthesis of N–H Aziridines from Unactivated Olefins Using Hydroxylamine-O-Sulfonic Acids as Aminating Agent J. Org. Chem. (IF 3.6) Pub Date : 2024-04-23 Yi Huang, Shi-Yang Zhu, Gang He, Gong Chen, Hao Wang
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Direct Oxidations of meso-Tetrakis(pentafluorophenyl)porphyrin: Porphotrilactones and Entry into a Nonbiological Porphyrin Degradation Pathway J. Org. Chem. (IF 3.6) Pub Date : 2024-04-23 Nisansala Hewage, Dinusha Damunupola, Matthias Zeller, Christian Brückner
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Challenges with the Synthesis of a Macrocyclic Thioether Peptide: From Milligram to Multigram Using Solid Phase Peptide Synthesis (SPPS) J. Org. Chem. (IF 3.6) Pub Date : 2024-04-23 James Kempson, Rulin Zhao, Joseph Pawluczyk, Bei Wang, Huiping Zhang, Xiaoping Hou, Martin P. Allen, Dauh-Rurng Wu, Peng Li, Shiuhang Yip, Aaron Smith, Sarah C. Traeger, Stella Huang, Jingfang Cutrone, Subha Mukherjee, Chris Sfouggatakis, Michael Poss, Paul M. Scola, Nicholas A. Meanwell, Percy H. Carter, Arvind Mathur
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Palladium-Catalyzed Carbohalogenation of Olefins with Alkynyl Oxime Ethers: Rapid Access to Chlorine-Containing Isoxazoles J. Org. Chem. (IF 3.6) Pub Date : 2024-04-23 Liren Zhang, Chenjing Hong, Junlong Tang, Wanqing Wu, Huanfeng Jiang
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Synthesis of Chiral 1,2-Amino Alcohol-Containing Compounds Utilizing Ruthenium-Catalyzed Asymmetric Transfer Hydrogenation of Unprotected α-Ketoamines J. Org. Chem. (IF 3.6) Pub Date : 2024-04-22 Hari P. R. Mangunuru, Leila Terrab, Venumadhav Janganati, Nageswara Rao Kalikinidi, Srinivasarao Tenneti, Vasudevan Natarajan, Arun D. R. Shada, Santhosh Reddy Naini, Praveen Gajula, Daniel Lee, Lalith P. Samankumara, Manasa Mamunooru, Aravindan Jayaraman, Rajkumar Lalji Sahani, Jinya Yin, Chathuranga C. Hewa-Rahinduwage, Aravind Gangu, Anji Chen, Zhirui Wang, Bimbisar Desai, Tai Y. Yue, Chaitanya
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Derivatization of 2,1,3-Benzothiadiazole via Regioselective C–H Functionalization and Aryne Reactivity J. Org. Chem. (IF 3.6) Pub Date : 2024-04-22 Susanna Kunz, Fredrik Barnå, Mauricio Posada Urrutia, Fredric J. L. Ingner, Andrea Martínez-Topete, Andreas Orthaber, Paul J. Gates, Lukasz T. Pilarski, Christine Dyrager
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Synthesis of Glycoconjugates through Chlorooxime–Thiol Conjugation J. Org. Chem. (IF 3.6) Pub Date : 2024-04-22 Wang Gu, Jingrong Huang, Yichi Lu, Wanzhen Lin, Wei Xu, Fa-Jie Chen
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CuI/Oxalamide-Catalyzed Coupling Reaction of (Hetero)aryl Halides with Sodium Nitrite J. Org. Chem. (IF 3.6) Pub Date : 2024-04-22 Sailuo Li, Dawei Ma
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Electrochemical Benzylic C–H Amination via N-Aminopyridinium J. Org. Chem. (IF 3.6) Pub Date : 2024-04-21 Jingwei Liu, Jinyao Du, Lin-Bao Zhang, Ming Li, Weisi Guo
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Selective Thermal Deprotection of N-Boc Protected Amines in Continuous Flow Org. Process Res. Dev. (IF 3.4) Pub Date : 2024-04-25 Michelle-Rose Ryan, Denis Lynch, Stuart G. Collins, Anita R. Maguire
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Efficient Synthesis of (S)-Nornicotine using Co-Immobilized IRED and GDH in Batch and Continuous Flow Reaction Systems Org. Process Res. Dev. (IF 3.4) Pub Date : 2024-04-25 Senling Guan, Wenfeng Zhou, Yongtang Yue, Songhe Wang, Bo Chen, Haishen Yang
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Enantioselective Synthesis of Axially Chiral Sulfone-Containing Styrenes Based on Ion-Exchange Strategy Org. Lett. (IF 5.2) Pub Date : 2024-04-25 Peng-Fei Lian, Ying Wang, Zi-Hao Li, Shu-Yu Zhang, Abing Duan, He-Yuan Bai
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TMSOTf-Catalyzed [4 + 2] Annulation of Ynamides and β-(2-Aminophenyl)-α,β-ynones for the Synthesis 2-Aminoquinolines Org. Lett. (IF 5.2) Pub Date : 2024-04-25 Chaofan Qi, Xiaoxiao Shen, Wozheng Fang, Junbiao Chang, Xiao-Na Wang
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Azidomethylation of Nucleobases and Related N-Heterocycles, Benzazoles, and Bis(arene)sulfonimides Using Azidomethyl Esters with Silyl Triflates Org. Lett. (IF 5.2) Pub Date : 2024-04-25 Ryoga Sawahata, Yuga Takagi, Yoshiaki Kitamura
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Asymmetric Synthesis of Hydrodibenzofurans from Norcaradienes: Kinetic Resolution via [3 + 2] Cycloaddition with Quinones Org. Lett. (IF 5.2) Pub Date : 2024-04-25 Siyuan Wang, Lichao Ning, Zhiqiang Li, Xiaoming Feng, Xiaohua Liu
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Fluorosulfonyl Arylation of Alkynes via Electron Donor–Acceptor Photoactivation Org. Lett. (IF 5.2) Pub Date : 2024-04-25 Haoyuan Cheng, Tianyu He, Dengfeng Chen, Yu Zheng, Yanju Lu, Hui Liang, Saihu Liao, Shenlin Huang
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Genome Mining of a Fungal Polyketide Synthase–Nonribosomal Peptide Synthetase Hybrid Megasynthetase Pathway to Synthesize a Phytotoxic N-Acyl Amino Acid Org. Lett. (IF 5.2) Pub Date : 2024-04-25 Lin Chen, Xin Wang, Yi Zou, Man-Cheng Tang
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Palladium-Catalyzed Defluorinative Alkylation of gem-Difluoroalkenes with Cyclopropanols: Stereoselective Synthesis of γ-Fluorinated γ,δ-Unsaturated Ketones Org. Lett. (IF 5.2) Pub Date : 2024-04-25 Lingyu Kong, Wenqing Ti, Aijun Lin, Hequan Yao, Yue Huang, Xuanyi Li
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Chemoselective Synthesis of 3-Bromomethyloxindoles via Visible-Light-Induced Radical Cascade Bromocyclization of Alkenes Org. Lett. (IF 5.2) Pub Date : 2024-04-25 Ming-Zhong Zhang, Xin Yang, Jin-Xing Yin, Ya Deng, Hong-Ying Tan, Yu-Heng Bai, Ya-Lin Li, Jiangwei Wen, Tieqiao Chen
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Copper-Catalyzed Chemoselective Coupling of N-Dithiophthalimides and Alkyl Halides: Synthesis of Unsymmetrical Disulfides and Sulfides Org. Lett. (IF 5.2) Pub Date : 2024-04-25 Bin Li, Bo-Xi Liu, Weidong Rao, Shu-Su Shen, Daopeng Sheng, Shun-Yi Wang
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Mild Strategy for the Preparation of Alkyl Sulfonyl Fluorides from Alkyl Bromides and Alcohols Using Photoredox Catalysis and Flow Chemistry Org. Lett. (IF 5.2) Pub Date : 2024-04-25 Alejandro Gutiérrez-González, Staffan Karlsson, Daniele Leonori, Mateusz P. Plesniak
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Stereoselective Preparation of the Tricyclic Hexasubstituted Spirocyclopropane Core of Cyclohelminthol X Org. Lett. (IF 5.2) Pub Date : 2024-04-24 Kazuki Hashimoto, Hayato Maeda, Masaru Hashimoto
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PIII/PV-Catalyzed Beckmann Reaction and Sequential [2,3]-Sigmatropic Rearrangement to Construct 2-Amidopyridines Org. Lett. (IF 5.2) Pub Date : 2024-04-24 Gang Sun, Yi-Han Yu, Han Kai, Fan-Ying Meng, Haoliang Yuan, Xiaoan Wen, Liu Liu, Qing-Long Xu
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One-Pot Synthesis of Bis(arylamino)pentiptycenes by TiCl4-DABCO Assisted Reductive Amination of Pentiptycene Quinone Org. Lett. (IF 5.2) Pub Date : 2024-04-24 Zhe-Jie Zhang, Ying-Feng Hsu, Chia-Chien Kao, Jye-Shane Yang
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Remote Radical Azidation of Unactivated C(sp3)–H Bonds in Sulfamoyl Azides Org. Lett. (IF 5.2) Pub Date : 2024-04-23 Jiawei Li, Sishi Zhong, Pan Zhou, Xu Li, Danyang Xie, Yunfei Cai, Yong Xia
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Deoxy-Arylation of Amides via a Tandem Hydrosilylation/Radical– Radical Coupling Sequence Org. Lett. (IF 5.2) Pub Date : 2024-04-23 Nicholas J. Venditto, Jeffrey A. Boerth
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Copper-Promoted Oxidative Amidation of Imines: A Facile Route to Amides Eur. J. Org. Chem. (IF 2.8) Pub Date : 2024-04-20 Zhonghua Cao, Da Sheng, Zhiyang Zhang, Haitao Ren, Yong Liu, Songhai Wu, Jiaxiang Zhang, Xu Han
Herein, an environmentally friendly and efficient amidation method of imines by Oxone and CuO has been developed. This facile method shows excellent selectivity without affecting other functional groups such as phenyls, halogens, cyans, esters or heterocycles. This method features a broad substrate scope, mild conditions and high yields (≤90%), and the yield in the gram scale experiment also reaches
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An Easy and Adjustable One-Pot Access to Pheromonal Blends of Fall Armyworm (Spodoptera frugiperda) Relying on a Key Ligand- and Additive-Free Iron-Catalyzed Cross-Coupling Org. Process Res. Dev. (IF 3.4) Pub Date : 2024-04-23 Pablo Chourreu, Olivier Guerret, Eric Gayon, Guillaume Lefèvre
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Forging the Tetracyclic Core Framework of Rhodomolleins XIV and XLII: A Ring-Distortion Approach Org. Lett. (IF 5.2) Pub Date : 2024-04-24 Zhen-Ning Yang, Huijuanzi Rao, Yuhao Yin, Shan Mu, Ziqi Jia, Hanfeng Ding