Abstract. The development of highly active and reusable supported catalysts for Suzuki‐Miyaura coupling and catalytic C‐H arylation is important for fundamental and applied chemistry, with these reactions being used to produce medical compounds and functional materials. Herein, we found that a mesoporous composite made of a linear poly(4‐vinylpyridine) and tetrachloropalladate acted as a dual‐mode

Azo dyes, in spite of being additives, are indeed an integral constituent of consumer goods with bio-therapeutic values. The addition of dyes is for consumer compliance which lends a sense of pleasing aesthetics to the consumption ready product, “a kind of placebo effect”. Consequently, imperative need of the hour is felt to quantify such azo dyes due to complications like skin allergic reactions,

A tandem synthesis of quinazolinones from 2-aminobenzonitriles is demonstrated here by using aliphatic alcohol-water system. For this transformation, cheap and easily available cobalt salt and P(CH2CH2PPh2)3 (PP3) ligand were employed. Substrate scope, scalability and synthesis of natural products exhibited the vitality of this protocol.

A simple chiral primary-tertiary diamine derived from C2-symmetric 1,2-diphenylethane-1,2-diamine as the organocatalyst in the combination with trifluoroacetic acid additive for the asymmetric Mannich reaction of cyclic N-sulfonyl trifluoromethylated ketimines and methyl ketones afforded the desired product with high enantioselectivity (73–96% ee). The reactions proceeded well for a variety of different

Cyclic anhydrides are versatile synthons and functional comonomers. Herein we reported an organic base-promoted carboxylative cyclization of 2-butenoates with carbon dioxide to produce important glutaconic anhydrides in good yields. This metal-free reaction showed broad substrate scopes and proceeded under mild reaction conditions.

TThree new dimeric bis-guanidinate zinc(II) alkyl, halide, hydride complexes [LZnEt]2 (1), [LZnI]2 (2) and [LZnH]2 (3) were prepared. Compound 3 was successfully employed for the hydrosilylation and hydroboration of a vast number of ketones. The catalytic performance of 3 in the hydroboration of acetophenone exhibits turn over frequency, reaching up to 5800 h-1, outperforming that of reported zinc

The high demand for new and efficient routes toward synthesis of nitrogen-containing heterocyclic scaffolds has inspired organic chem-ists to discover several methodologies over recent years. This perspective highlights one standout approach, which involves the use of pyri-dotriazoles and related compounds in denitrogenative transformations. Readily available pyridotriazoles undergo ring-chain isomeriza-tion

The value of the free energy of H2 heterolysis into H+ and H– (ΔG°H2) in N,N-dimethylformamide (DMF) solvent was incorrectly transcribed in Table 1. A revised version of Table 1, with the new value for DMF (which changed by −0.2 kcal/mol), is presented below. The legend of Figure 4 was also incorrect as originally published. A revised version of Figure 4 is shown below. Because the overall trends were

A framework for the digital design of batch cooling crystallisation processes is presented comprising three stages which are based on different levels of process complexity, integrating crystalliser hydrodynamics with crystallisation kinetics and consequently with expected crystal size distribution. In the first stage of the framework, a CFD methodology is developed to accurately assess hydrodynamics

N,N-dimethylformamide (DMF) is frequently used as a solvent because of its unique physical properties that solubilize both organic and inorganic substances. It has also found broad applications as a catalyst for a variety of chemical transformations as well as a donor for many functional groups in synthetic organic chemistry. However, DMF is incompatible with a wide variety of substances and has resulted

Isothiourea was first employed as catalyst by Birman in 2006 for the enantioselective acyl transfer reaction. The catalyst was then well explored in the course of kinetic resolution and desymmetrization studies. A few years later, Romo and Smith applied isothiourea catalysis in enantioselective cascade reactions to prepare carbocycles and heterocycles acessing new reactivities of isothiourea. Several

A series of novel pyridazinone derivatives were designed and synthesized by replacing 4‐(tert‐butyl)phenyl moiety of pyridaben with 2‐phenylthiazole or oxazole fragments via activity substructure connecting approach. The structures of all target compounds were characterized through NMR, MS, and elemental analysis. Bioassay results exhibit that most compounds showed potent bioactivities against Aphis

One‐pot four component reactions of phenacyl bromides, parabanic or thioparabanic acids, thiophenols and triphenylphosphine in the presence of triethylamine afforded new derivatives of hydantoin or thiohydantoin in good to high yieilds (65‐90%). Their antibacterial activities were evaluated against two Gram‐positive bacteria (Staphylococcus aureus and Bacillus subtilis) and two Gram‐negative bacteria

An efficient procedure has been developed for the synthesis of bis(indolyl)methanes (3a-m) from condensation of indole (1) and various substituted aromatic aldehydes (2a-m) is described. The aromatic electrophilic substitution reactions of indole (1) with and various substituted aromatic aldehydes (2a-m) are achieved in solvent- and catalyst free condition using irradiation with 150W tungsten lamp

In this study, a total of 17 piece 2,5-disubstituted benzoxazole derivatives were synthesized, 2 of which were not original, their antimicrobial activities were determined using microdilution method and their in vitro cytotoxic activities were investigated on MCF-7 and A549 cells by MTT test. When the activity results are examined, although the antibacterial effects of benzoxazole derivatives are weaker

The reaction of pentachloropyridine with indoles and bis(indolyl)methanes (BIMs) were investigated. Indoles in basic medium exclusively react with pentachloropyridine to give the corresponding N-perhalopyridine substituted indoles. Furthermore, BIMs in reaction with pentachloropyridine gave N-perfluoropyridinated BIMs and N,N´-bis(perfluoropyridyl) bis(indolyl)methane derivatives, as major and minor