The Long-chain Diol Index (LDI) is a palaeotemperature proxy applied to marine sediments up to Miocene in age. Recent studies have revealed that the LDI-inferred temperature yields significant errors in waters > 27 °C. This necessitates further assessment of the performance of the LDI proxy in high-temperature marine regimes. For this purpose, we collected 58 surface sediment samples from the tropical

The trifluoromethylated N‐ acylhydrazones are used as dipolarophile to perform 1,3‐dipolar cycloaddition with azomethine ylides to afford trifluoromethylated 1,2,4,5‐tetrasubstituted imidazolidines in good yields under mild conditions. The role switch of the trifluoromethylated N ‐acylhydrazones demonstrates that they are versatile trifluoromethyl building blocks for CF 3 ‐containing heterocycles.

Design of magnetic hybrid nanomaterials for cooperative activation of diverse functional groups drive the future nanocatalysis toward green and sustainable multi‐component organic synthesis. Here we report the synthesis of unique Ni@CuI hybrid nanocatalysts by oxidation of Cu 0 surface in Ni@Cu core‐shell precursor using ethanolic I 2 solution. The morphological (scanning electron microscopy and energy‐dispersive

Two chiral trilactams, the cup‐shaped ( − )‐ 1 and bowl‐shaped ( − )‐ 2 was synthesized. Single crystal X‐ray analysis revealed that ( − )‐ 1 formed dimer structure by the formation of three NH ∙∙∙ O type complementary hydrogen bonds at three amide moieties. T he equilibrium constant ( K eq ) and kinetic parameters ∆ H ° and ∆ S ° of the dimer formation phenomenon of ( − )‐ 1 were determined by variable

A photocatalytic strategy for regioselective synthesis of phenanthridine derivatives from N-(2-arylbenzylidenamino)pyridinium salts has been developed. Utilization of an Ir photocatalyst, [Ir{dF(CF3)ppy}2(dtbbpy)]PF6 (dF(CF3)ppy = 3,5-difluoro-2-(5-(trifluoromethyl)-2-pyridyl)phenyl, dtbbpy = 4,4’-di-tert-butyl-2,2’-bipyridine), is a key to successful reactions. The excited Ir catalyst does not serve

The synthesis of tumor-associated KH-1 antigen core nonasaccharide was achieved. All key glycosidic linkages were efficiently constructed by photo-induced glycosylation. The success of this total synthesis sets up an example for the preparation of complex oligosaccharides by using light-driven glycosylation reactions.

A facile, one-step synthesis of annulated indoles from (N–H) indoles and dibromoalkanes was developed through a palladium-catalyzed double alkylation process. The reaction proceeds through a palladium-catalyzed norbornene-mediated C2-alkylation of indoles and subsequent regioselective cyclization. The reaction is compatible with various indole substituents, as well as a range of simple and functionalized

A unique phenylboronic acid-catalyzed dimerization–sulfonylation of S-benzyl thiosulfonates have been disclosed. A metal-free tandem construction of S-S and C-S bonds is an operationally simple to access a wide range of benzyl disulfanylsulfone derivatives in high to excellent yields. Moreover, the robustness of this tandem transformation has been demonstrated by gram-scale reactions, and a plausible

A series of 3-(hetero)aryl-substituted benzo[b]thieno[2,3-d]thiophenes, bearing various electron withdrawing groups at C-2 position of their scaffolds, were obtained using a convenient approach based on the Fiesselmann thiophene synthesis. To realize this strategy, the Friedel–Crafts acylation of (hetero)arenes with easily accessible 3-chlorobenzo[b]thiophene-2-carbonyl chlorides was initially performed

The investigation on tandem addition/cyclization reactions of -(2-aminophenyl) ,-ynones with aryl isocyanates/ benzoyl isothiocyanate is reported. Experimental results show the suitable conditions to selectivity direct the reaction outcome towards the product of 6-exo-dig N-, O-, or S-annulation of the in situ generated alkynyl urea/thiourea intermediate. The reaction of a variety of β-(2-aminophenyl)

A concise asymmetric synthesis of two naturally occurring seco-type cholestane alkaloids (-)-solanidine and (-)-tomatidenol from (-)-diosgenin with a linear reaction sequence of 12 steps and 13 steps, respectively is reported. The synthetic strategy includes the highly controlled establishment of highly functionalized octahydroindolizine ((-)-solanidine) and 1-oxa-6-azaspiro[4.5]decane cores ((-)-tomatidenol)

A sesquiterpene synthase from Streptomyces bungoensis was characterised and produces the new natural product bungoene. The enzyme mechanism was deeply investigated using isotopically labelled substrates. Two other enzymes from S. bungoensis made epi-isozizaene and pentalenene. Synthetic oxidative chemistry towards structurally related fusagramineol and pentalenal was explored.