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A cationic amphiphilic drug synergizes with strobilurin fungicides to control fungal-borne plant diseases Cell Chem. Bio. (IF 6.6) Pub Date : 2025-06-11 Bradley Laflamme, Christopher Blackman, Mackenzie Loranger, Richard Trilles, Kalina Doytchinova-Weil, Stephen S. Scully, J. Miles Blackburn, Anastasia L.G. Kanegesuku, Jennifer L. Roizen, Stephen Bengtson, Lauren E. Brown, John A. Porco, Keiko Yoshioka, Luke Whitesell, Rajagopal Subramaniam, Nicole Robbins, Leah E. Cowen
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EGR2 O-GlcNAcylation orchestrates the development of protumoral macrophages to limit CD8+ T cell antitumor responses Cell Chem. Bio. (IF 6.6) Pub Date : 2025-06-10 Yuchen Zhang, Hongpeng Li, Yi Hao, Jiaqi Chen, Xing Chen, Hang Yin
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Redundancy of the OST catalytic subunit facilitates therapeutic targeting of N-glycosylation Cell Chem. Bio. (IF 6.6) Pub Date : 2025-06-09 Marta Baro, Hojin Lee, Vanessa Kelley, Rongliang Lou, Chatchai Phoomak, Katerina Politi, Caroline J. Zeiss, Michael Van Zandt, Joseph N. Contessa
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Charting the development and engineering of CRISPR base editors: lessons and inspirations Cell Chem. Bio. (IF 6.6) Pub Date : 2025-06-05 Siyuan Zou, Yihong Sun, Weixin Tang
CRISPR base editors (BEs) have introduced a new chapter in precise genome editing. The brief but fruitful history of BE development documents many case studies that not only lay the foundation of base-editing technology but are also instrumental to future protein engineering efforts. In this review, we summarize the development and engineering of various BEs with a focus on recent progress. These include
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Mechanism by which the molecular glue-like verteporfin induces IRE1α dimerization and activation to synergize with AKT inhibition in breast cancer Cell Chem. Bio. (IF 6.6) Pub Date : 2025-06-04 Yongliang Liu, Hui Hua, Yalan Cao, Minjing Li, Hongying Zhang, Shan Du, Jieya Liu, Ting Luo, Yangfu Jiang
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Electrochemical sensor toolkit for simultaneous glutamate detection at edge of cleft and peri-soma Cell Chem. Bio. (IF 6.6) Pub Date : 2025-06-03 Jie Liu, Yuandong Liu, Dongmin Yin, Yang Tian
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The critical role of PSAC channel in malaria parasite survival is driven home by phenotypic screening under relevant nutrient levels Cell Chem. Bio. (IF 6.6) Pub Date : 2025-05-23 Irene Molina, Ryan Mansell, Rui Liang, Benigno Crespo, Margarita Puente, Virginia Franco, Sara Viera, Isabel Camino, Anas Saadeddin, Peter Bellotti, Annie Leung, Sam Henning, Shan Sun, Mikayla Herring, Celia Lopez, Carmen Cuevas, Peter Pogány, Beatriz Urones, Leigh Baxt, Esther Fernández, Lydia Mata-Cantero
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Meet the authors: Mitchel L. Tepe and Huiqing Zhou Cell Chem. Bio. (IF 6.6) Pub Date : 2025-05-15 Mitchel L. Tepe, Huiqing Zhou
In an interview with Dr. Samantha Nelson, a scientific editor of Cell Chemical Biology, the authors of the Resource article entitled “MapID-based quantitative mapping of chemical modifications and expression of human transfer RNA” share their perspectives on their field and life as scientists.
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Meet the Cell Chemical Biology author and newest advisory board member: Marcus Conrad Cell Chem. Bio. (IF 6.6) Pub Date : 2025-05-15 Marcus Conrad
In an interview with Dr. Mishtu Dey, the editor-in-chief of Cell Chemical Biology, Prof. Marcus Conrad, a new advisory board member and lead author of the paper entitled “N-acetyl-L-cysteine averts ferroptosis by fostering glutathione peroxidase 4,” shares his perspective on his research area, opportunities in the chemical biology field, and his plans to meaningfully contribute in this new position
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Meet the authors: Xing Zhang, Kyong Fam, Tingting Dai, and Howard Hang Cell Chem. Bio. (IF 6.6) Pub Date : 2025-05-15 Xing Zhang, Kyong Fam, Tingting Dai, Howard Hang
In an interview with Dr. Mishtu Dey, the editor-in-chief of Cell Chemical Biology, the authors of the Review article entitled “Microbiota mechanisms in cancer progression and therapy” share their perspectives on their field and lives as scientists.
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Decoding the minute-by-minute GPCR interactome unveils hormone signaling gatekeepers Cell Chem. Bio. (IF 6.6) Pub Date : 2025-05-15 Wenqing Shui
In this issue of Cell Chemical Biology, Shchepinova et al.1 map the luteinizing hormone receptor (LHR) interactome with sub-minute precision. They identify novel regulators, such as RAP2B, which influences cAMP signaling and endosomal trafficking, enhancing our understanding of GPCR-mediated intracellular signaling and interactome dynamics.
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Engineering ERα degraders with pleiotropic ubiquitin ligase ligands maximizes therapeutic efficacy by co-opting distinct effector ligases Cell Chem. Bio. (IF 6.6) Pub Date : 2025-05-15 Anna Shemorry, Willem den Besten, Melinda M. Mulvihill, Curt J. Essenburg, Nicole Blaquiere, Tracy Kleinheinz, Elisia Villemure, Frank Peale, Gauri Deshmukh, Danilo Maddalo, Elizabeth Levy, Kebing Yu, Matthew R. Steensma, Elizabeth A. Tovar, Emily Wolfrum, Karthik Nagapudi, Robert A. Blake, William F. Forrest, Steven T. Staben, Carrie R. Graveel, Wayne J. Fairbrother, Ingrid E. Wertz
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Pantothenate kinase is an effective target for antifungal therapy Cell Chem. Bio. (IF 6.6) Pub Date : 2025-05-15 Jessica Regan, Christian DeJarnette, Parker Reitler, Shalev Gihaz, Ashish Srivastava, Wenbo Ge, Katie M. Tucker, Tracy L. Peters, Bernd Meibohm, Choukri Ben Mamoun, Jarrod R. Fortwendel, Kirk E. Hevener, Glen E. Palmer
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Spatiotemporally resolved GPCR interactome uncovers unique mediators of receptor agonism Cell Chem. Bio. (IF 6.6) Pub Date : 2025-05-15 Maria M. Shchepinova, Rachel Richardson, Jack W. Houghton, Abigail R. Walker, Mohammed A. Safar, Daniel Conole, Aylin C. Hanyaloglu, Edward W. Tate
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Microbiota mechanisms in cancer progression and therapy Cell Chem. Bio. (IF 6.6) Pub Date : 2025-05-06 Xing Zhang, Kyong Tkhe Fam, Tingting Dai, Howard C. Hang
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Integrative proximal-ubiquitomics profiling for deubiquitinase substrate discovery applied to USP30 Cell Chem. Bio. (IF 6.6) Pub Date : 2025-05-05 Andreas Damianou, Hannah B.L. Jones, Athina Grigoriou, Mohammed A. Akbor, Edward Jenkins, Philip D. Charles, Iolanda Vendrell, Simon Davis, Benedikt M. Kessler
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MapID-based quantitative mapping of chemical modifications and expression of human transfer RNA Cell Chem. Bio. (IF 6.6) Pub Date : 2025-05-02 Mitchel L. Tepe, Yitan Chen, Allison Carso, Huiqing Zhou
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N-acetyl-l-cysteine averts ferroptosis by fostering glutathione peroxidase 4 Cell Chem. Bio. (IF 6.6) Pub Date : 2025-04-30 Jiashuo Zheng, Weijia Zhang, Junya Ito, Bernhard Henkelmann, Chenxi Xu, Eikan Mishima, Marcus Conrad
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Impact of radiation therapy on the immunological tumor microenvironment Cell Chem. Bio. (IF 6.6) Pub Date : 2025-04-24 Emma Guilbaud, Flavie Naulin, Lydia Meziani, Eric Deutsch, Lorenzo Galluzzi
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CDK2 heterobifunctional degraders co-degrade CDK2 and cyclin E resulting in efficacy in CCNE1-amplified and overexpressed cancers Cell Chem. Bio. (IF 6.6) Pub Date : 2025-04-17 Nicholas Kwiatkowski, Tong Liang, Zhe Sha, Philip N. Collier, Annan Yang, Murugappan Sathappa, Atanu Paul, Lijing Su, Xiaozhang Zheng, Robert Aversa, Kunhua Li, Revonda Mehovic, Christina Kolodzy, Susanne B. Breitkopf, Dapeng Chen, Charles L. Howarth, Karen Yuan, Hakryul Jo, Joseph D. Growney, Matthew Weiss, Juliet Williams
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Genetically encoded tool for manipulation of ΔΨm identifies its role as the driver of ISR induced by ATP synthase dysfunction Cell Chem. Bio. (IF 6.6) Pub Date : 2025-04-17 Mangyu Choe, Alex E. Ekvik, Gretchen Stalnaker, Hijai R. Shin, Denis V. Titov
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Molecular mechanism of PP2A/B55α phosphatase inhibition by IER5 Cell Chem. Bio. (IF 6.6) Pub Date : 2025-04-09 Ruili Cao, Daniel T.D. Jones, Li Pan, Annie Yang, Shumei Wang, Sathish K.R. Padi, Shaun Rawson, Jon C. Aster, Stephen C. Blacklow
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Streptomycin targets tumor-initiating cells by disrupting oxidative phosphorylation Cell Chem. Bio. (IF 6.6) Pub Date : 2025-04-09 Hélène Guillorit, Sébastien Relier, Benjamin Zagiel, Audrey Di Giorgio, Chris Planque, Bastien Felipe, Hélène Hérault, Lucile Bansard, Céline Bouclier, Béatrice Chabi, François Casas, Ornella Clara, Béatrice Bonafos, Xavier Mialhe, Chantal Cazevieille, Szimonetta Hideg, Armelle Choquet, Amandine Bastide, Julie Pannequin, Maria Duca, Françoise Macari, Alexandre David
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Natural products chlorotonils exert a complex antibacterial mechanism and address multiple targets Cell Chem. Bio. (IF 6.6) Pub Date : 2025-04-08 Felix Deschner, Dietrich Mostert, Jan-Martin Daniel, Alexander Voltz, Dana Carina Schneider, Navid Khangholi, Jürgen Bartel, Laís Pessanha de Carvalho, Madita Brauer, Tatiana E. Gorelik, Christian Kleeberg, Timo Risch, F.P. Jake Haeckl, Laura Herraiz Benítez, Anastasia Andreas, Andreas Martin Kany, Gwenaëlle Jézéquel, Walter Hofer, Mathias Müsken, Jana Held, Markus Bischoff, Ralf Seemann, Heike Brötz-Oesterhelt
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Understanding, inhibiting, and engineering membrane transporters with high-throughput mutational screens Cell Chem. Bio. (IF 6.6) Pub Date : 2025-03-31 Silas T. Miller, Christian B. Macdonald, Srivatsan Raman
Promiscuous membrane transporters play vital roles across domains of life, mediating the uptake and efflux of structurally and chemically diverse substrates. Although many transporter structures have been solved, the fundamental rules of polyspecific transport remain inscrutable. In recent years, high-throughput genetic screens have solidified as powerful tools for comprehensive, unbiased measurements
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Visualization of calpain-1 activation during cell death and its role in GSDMD cleavage using chemical probes Cell Chem. Bio. (IF 6.6) Pub Date : 2025-03-28 Natalia Horbach, Małgorzata Kalinka, Natalia Ćwilichowska-Puślecka, Abdulla Al Mamun, Agata Mikołajczyk-Martinez, Boris Turk, Scott J. Snipas, Paulina Kasperkiewicz, Katarzyna M. Groborz, Marcin Poręba
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Targeted degradation of CDK9 potently disrupts the MYC-regulated network Cell Chem. Bio. (IF 6.6) Pub Date : 2025-03-27 Mohammed A. Toure, Keisuke Motoyama, Yichen Xiang, Julie Urgiles, Florian Kabinger, Ann-Sophie Koglin, Ramya S. Iyer, Kaitlyn Gagnon, Amruth Kumar, Samuel Ojeda, Drew A. Harrison, Matthew G. Rees, Jennifer A. Roth, Christopher J. Ott, Richard Schiavoni, Charles A. Whittaker, Stuart S. Levine, Forest M. White, Eliezer Calo, Andre Richters, Angela N. Koehler
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Targeting biomolecular condensates: The rise of engineered chaperones Cell Chem. Bio. (IF 6.6) Pub Date : 2025-03-20 Yevheniia Bushman, Duhita A. Mirikar, Andrew W. Truman
Molecular chaperones like Hsp70s are key players in protein quality control (PQC), capable of eliminating toxic intracellular condensates. In this issue of Cell Chemical Biology, Zhang et al.1 present a computational approach to design novel J-domain protein (JDP) constructs that bind to Hsp70 and enhance its chaperone activity.
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Lipid it up: Freed fats drive ferroptosis Cell Chem. Bio. (IF 6.6) Pub Date : 2025-03-20 Madison S. Mortensen, Jennifer L. Watts
Polyunsaturated fats promote ferroptosis through their propensity to form toxic lipid peroxides. In this issue of Cell Chemical Biology, Sokol et al.1 report that extracellular lipid depletion leads to increased cell death by ferroptosis. This occurs because fats liberated from triglycerides are modified and incorporated into cellular phospholipids.
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Disrupting neuron-tumor networking connections Cell Chem. Bio. (IF 6.6) Pub Date : 2025-03-20 Cheng-En Shen, Alesandra S. Echeandía Marrero, Yuan Pan
Neurons are key to brain tumor pathogenesis. Though direct synaptic connections between neurons and glioblastoma cells had been revealed, the nature of such connections remained enigmatic. In a recent issue of Cell, Tetzlaff et al.1 leveraged monosynaptic retrograde tracing to pinpoint these interactions, demonstrating new therapeutic strategies for targeting malignant neuron-glioma crosstalk.
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Epigenetic fluidity meets phenotypic malleability in intestinal epithelial cells Cell Chem. Bio. (IF 6.6) Pub Date : 2025-03-20 Swarnabh Bhattacharya, Ramesh A. Shivdasani
Differentiated progenitors in intestinal crypts react to stem cell attrition by reverting to the multipotent state. In the February issue of Nature Cell Biology, Pashos et al.1 reveal a role for H3K36 methylation at cell-type-restricted genes in helping maintain differentiated cell states, hence regulating cell plasticity and regenerative responses.
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An affinity-based depletion strategy for evaluating the effects of ergothioneine on bacterial physiology Cell Chem. Bio. (IF 6.6) Pub Date : 2025-03-10 Anna B. Seminara, Stavroula K. Hatzios
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Mechanisms and functions of lysosomal lipid homeostasis Cell Chem. Bio. (IF 6.6) Pub Date : 2025-03-06 Michael Ebner, Florian Fröhlich, Volker Haucke
Lysosomes are the central degradative organelle of mammalian cells and have emerged as major intersections of cellular metabolite flux. Macromolecules derived from dietary and intracellular sources are delivered to the acidic lysosomal lumen where they are subjected to degradation by acid hydrolases. Lipids derived from lipoproteins, autophagy cargo, or autophagosomal membranes themselves constitute
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VIPER-TACs leverage viral E3 ligases for disease-specific targeted protein degradation Cell Chem. Bio. (IF 6.6) Pub Date : 2025-03-05 Kyle Mangano, Robert G. Guenette, Spencer Hill, Shiqian Li, Jeffrey J. Liu, Cory M. Nadel, Suresh Archunan, Arghya Sadhukhan, Rajiv Kapoor, Seung Wook Yang, Kate S. Ashton, Patrick Ryan Potts
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Antibiotic target discovery by integrated phenotypic and activity-based profiling of electrophilic fragments Cell Chem. Bio. (IF 6.6) Pub Date : 2025-02-27 Yizhen Jin, Sadhan Jana, Mikail E. Abbasov, Hening Lin
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Dynamic PRDX S-acylation modulates ROS stress and signaling Cell Chem. Bio. (IF 6.6) Pub Date : 2025-02-25 Tian Qiu, Saara-Anne Azizi, Shubhashree Pani, Bryan C. Dickinson
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NAPE-PLD is target of thiazide diuretics Cell Chem. Bio. (IF 6.6) Pub Date : 2025-02-24 Sara Chiarugi, Francesco Margheriti, Valentina De Lorenzi, Elisa Martino, Eleonora Germana Margheritis, Aldo Moscardini, Roberto Marotta, Antonio Chaves-Sanjuan, Cristina Del Seppia, Giuseppe Federighi, Dominga Lapi, Tiziano Bandiera, Simona Rapposelli, Rossana Scuri, Martino Bolognesi, Gianpiero Garau
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Ligand-induced assembly of antibody variable fragments for the chemical regulation of biological processes Cell Chem. Bio. (IF 6.6) Pub Date : 2025-02-13 Erik Rihtar, Tina Fink, Tina Lebar, Duško Lainšček, Živa Kolenc, Lucija Kadunc Polajnar, Roman Jerala
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De novo designed Hsp70 activator dissolves intracellular condensates Cell Chem. Bio. (IF 6.6) Pub Date : 2025-02-07 Jason Z. Zhang, Nathan Greenwood, Jason Hernandez, Josh T. Cuperus, Buwei Huang, Bryan D. Ryder, Christine Queitsch, Jason E. Gestwicki, David Baker
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An oral tricyclic STING agonist suppresses tumor growth through remodeling of the immune microenvironment Cell Chem. Bio. (IF 6.6) Pub Date : 2025-02-03 Hong-Yi Zhao, Zhongwei Liu, Jinsong Tao, Shuai Mao, Meilin Wang, Miao He, Bo Wen, Wei Gao, Duxin Sun
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Engineering electrogenetic interfaces for mammalian cell control Cell Chem. Bio. (IF 6.6) Pub Date : 2025-01-28 Maysam Mansouri, Martin Fussenegger
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A genetically encoded fluorescent biosensor for visualization of acetyl-CoA in live cells Cell Chem. Bio. (IF 6.6) Pub Date : 2025-01-27 Joseph J. Smith, Taylor R. Valentino, Austin H. Ablicki, Riddhidev Banerjee, Adam R. Colligan, Debra M. Eckert, Gabrielle A. Desjardins, Katharine L. Diehl
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SynPull: An advanced method for studying neurodegeneration-related aggregates in synaptosomes using super-resolution microscopy Cell Chem. Bio. (IF 6.6) Pub Date : 2025-01-24 Shekhar Kedia, Emre Fertan, Yunzhao Wu, Yu P. Zhang, Georg Meisl, Jeff Y.L. Lam, Frances K. Wiseman, William A. McEwan, Annelies Quaegebeur, Maria Grazia Spillantini, John S.H. Danial, David Klenerman
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Meet the authors: Aayushi Uberoi and Elizabeth A. Grice Cell Chem. Bio. (IF 6.6) Pub Date : 2025-01-16 Aayushi Uberoi, Elizabeth A. Grice
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Meet the authors: Katerina Jones, Camila Bernardo de Brito, and Mariana Xavier Byndloss Cell Chem. Bio. (IF 6.6) Pub Date : 2025-01-16 Katerina Jones, Camila Bernardo de Brito, Mariana Xavier Byndloss
In an interview with Samantha Nelson, a scientific editor of Cell Chemical Biology, the authors of the review entitled “Metabolic tug-o-war: Microbial metabolism shapes colonization resistance against enteric pathogens” share their perspectives on the field and their lives as scientists.
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New opportunities in mechanistic and functional microbiome studies Cell Chem. Bio. (IF 6.6) Pub Date : 2025-01-16 Judith Behnsen, Kerwyn Casey Huang, Matthew T. Sorbara, Meng C. Wang, Jun Yu, Melody Y. Zeng
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Yeast paves the way for cancer immunotherapy Cell Chem. Bio. (IF 6.6) Pub Date : 2025-01-16 Dingjiacheng Jia, Shujie Chen
In this issue of Cell Chemical Biology, Rebeck et al.1 construct a system that enables Saccharomyces cerevisiae var. boulardii (Sb) to secrete immune checkpoint inhibitors, reducing intestinal tumor load. This safe and effective delivery platform using engineered yeast demonstrates potential for enhancing the efficacy of biologics.
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Metabolic tug-of-war: Microbial metabolism shapes colonization resistance against enteric pathogens Cell Chem. Bio. (IF 6.6) Pub Date : 2025-01-16 Katerina Jones, Camila Bernardo de Brito, Mariana Xavier Byndloss
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Commensal-derived tryptophan metabolites fortify the skin barrier: Insights from a 50-species gnotobiotic model of human skin microbiome Cell Chem. Bio. (IF 6.6) Pub Date : 2025-01-16 Aayushi Uberoi, Sofía M. Murga-Garrido, Preeti Bhanap, Amy E. Campbell, Simon A.B. Knight, Monica Wei, Anya Chan, Taylor Senay, Saba Tegegne, Ellen K. White, Carrie Hayes Sutter, Clementina Mesaros, Thomas R. Sutter, Elizabeth A. Grice
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A widespread and ancient bacterial machinery assembles cytochrome OmcS nanowires essential for extracellular electron transfer Cell Chem. Bio. (IF 6.6) Pub Date : 2025-01-15 Cong Shen, Aldo I. Salazar-Morales, Wonhyeuk Jung, Joey Erwin, Yangqi Gu, Anthony Coelho, Kallol Gupta, Sibel Ebru Yalcin, Fadel A. Samatey, Nikhil S. Malvankar
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Small molecules targeting selective PCK1 and PGC-1α lysine acetylation cause anti-diabetic action through increased lactate oxidation Cell Chem. Bio. (IF 6.6) Pub Date : 2025-01-15 Beste Mutlu, Kfir Sharabi, Jee Hyung Sohn, Bo Yuan, Pedro Latorre-Muro, Xin Qin, Jin-Seon Yook, Hua Lin, Deyang Yu, João Paulo G. Camporez, Shingo Kajimura, Gerald I. Shulman, Sheng Hui, Theodore M. Kamenecka, Patrick R. Griffin, Pere Puigserver
(Cell Chemical Biology 31, 1772–1786.e1–e5; October 17, 2024)
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Targeting N-Myc in neuroblastoma with selective Aurora kinase A degraders Cell Chem. Bio. (IF 6.6) Pub Date : 2025-01-07 Jian Tang, Ramkumar Moorthy, Laura E. Hirsch, Özlem Demir, Zachary D. Baker, Jordan A. Naumann, Katherine F.M. Jones, Michael J. Grillo, Ella S. Haefner, Ke Shi, Michaella J. Levy, Harshita B. Gupta, Hideki Aihara, Reuben S. Harris, Rommie E. Amaro, Nicholas M. Levinson, Daniel A. Harki
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The right tool for the job: Chemical biology and microbiome science Cell Chem. Bio. (IF 6.6) Pub Date : 2025-01-06 Christopher Whidbey
Microbiomes exist in ecological niches ranging from the ocean and soil to inside of larger organisms like plants and animals. Within these niches, microbes play key roles in biochemical processes that impact larger phenomena, such as biogeochemical cycling or health. By understanding of how these processes occur at the molecular level, it may be possible to develop new interventions to address global
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The efflux pump ABCC1/MRP1 constitutively restricts PROTAC sensitivity in cancer cells Cell Chem. Bio. (IF 6.6) Pub Date : 2025-01-03 Gernot Wolf, Conner Craigon, Shao Thing Teoh, Patrick Essletzbichler, Svenja Onstein, Diane Cassidy, Esther C.H. Uijttewaal, Vojtech Dvorak, Yuting Cao, Ariel Bensimon, Ulrich Elling, Alessio Ciulli, Giulio Superti-Furga
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Development of an FKBP12-recruiting chemical-induced proximity DNA-encoded library and its application to discover an autophagy potentiator Cell Chem. Bio. (IF 6.6) Pub Date : 2025-01-02 Zher Yin Tan, Joel K.A. Adade, Xiebin Gu, Cody J.S. Hecht, Michael Salcius, Bingqi Tong, Shuang Liu, Seungmin Hwang, Frédéric J. Zécri, Daniel B. Graham, Stuart L. Schreiber, Ramnik J. Xavier
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Calcineurin: An essential regulator of sleep revealed by biochemical, chemical biological, and genetic approaches Cell Chem. Bio. (IF 6.6) Pub Date : 2024-12-30 Jianjun Yu, Huijie Liu, Rui Gao, Tao V. Wang, Chenggang Li, Yuxiang Liu, Lu Yang, Ying Xu, Yunfeng Cui, Chenxi Jia, Juan Huang, Peng R. Chen, Yi Rao
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Discovery of a Pseudomonas aeruginosa-specific small molecule targeting outer membrane protein OprH-LPS interaction by a multiplexed screen Cell Chem. Bio. (IF 6.6) Pub Date : 2024-12-27 Bradley E. Poulsen, Thulasi Warrier, Sulyman Barkho, Josephine Bagnall, Keith P. Romano, Tiantian White, Xiao Yu, Tomohiko Kawate, Phuong H. Nguyen, Kyra Raines, Kristina Ferrara, A. Lorelei Golas, Michael FitzGerald, Andras Boeszoermenyi, Virendar Kaushik, Michael Serrano-Wu, Noam Shoresh, Deborah T. Hung
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Anti-tumor immunotherapy using engineered bacterial outer membrane vesicles fused to lysosome-targeting chimeras mediated by transferrin receptor Cell Chem. Bio. (IF 6.6) Pub Date : 2024-12-24 Ling-Yan Su, Yang Tian, Qiang Zheng, Yu Cao, Mengyu Yao, Shuangping Wang, Wen Xu, Chuyu Xi, Andrea Clocchiatti, Guangjun Nie, Hejiang Zhou
(Cell Chemical Biology 31, 1219–1230.e1–e5; June 20, 2024)
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D-aring to explore: New approaches to gasdermin D targeting Cell Chem. Bio. (IF 6.6) Pub Date : 2024-12-19 Lei Wang, Wen Zhou
Novel inhibitors of pyroptosis promise breakthroughs in treating inflammatory diseases and malignant tumors. In this issue of Cell Chemical Biology, Hu et al.1 identify two repurposed drugs that selectively target gasdermin D (GSDMD) oligomers, effectively suppressing pyroptosis while reducing off-target effects typical of cysteine-based inhibitors.
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FAAHcilitating recovery in malnourished kids Cell Chem. Bio. (IF 6.6) Pub Date : 2024-12-19 Franciscus Chandra, Elaine Y. Hsiao
The molecular underpinnings behind the diet-microbiome-host health relationship are largely undescribed. In a recent issue of Science, Cheng et al.1 uncovered one piece of the puzzle by describing a novel fatty acid amide hydrolase (FAAH) derived from a Faecalibacterium prausnitzii strain that correlated with improved malnutrition recovery. This emphasized the microbiome’s role in supporting recovery