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Targeting METTL3 reprograms the tumor microenvironment to improve cancer immunotherapy Cell Chem. Bio. (IF 8.6) Pub Date : 2023-09-25 Haisheng Yu, Jing Liu, Xia Bu, Zhiqiang Ma, Yingmeng Yao, Jinfeng Li, Tiantian Zhang, Wenjing Song, Xiangling Xiao, Yishuang Sun, Wenjun Xiong, Jie Shi, Panpan Dai, Bolin Xiang, Hongtao Duan, Xiaolong Yan, Fei Wu, Wen Cai Zhang, Dandan Lin, Hankun Hu, Jinfang Zhang
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Challenges and opportunities in targeting metabolism Cell Chem. Bio. (IF 8.6) Pub Date : 2023-09-21 Kivanç Birsoy, Navdeep S. Chandel, Sarah-Maria Fendt, Douglas R. Green, Xiaoling Li, Deborah M. Muoio
Over the past decade or two, targeting metabolism has been effective in the treatment of many diseases and disorders, particularly cancer. In a metabolism focus issue in Cell Chemical Biology, this Voices piece asks researchers from a range of backgrounds: what are some major challenges and opportunities facing the field in the coming years?
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Glutamine availability unleashes dendritic cells’ anti-tumor power Cell Chem. Bio. (IF 8.6) Pub Date : 2023-09-21 Mauro Corrado, Christian Frezza
Metabolic competition within the tumor microenvironment (TME) shapes the efficacy of anticancer immunity. In the August 3rd issue of Nature, Guo et al.1 show that glutamine is an intercellular metabolic checkpoint between cancer and immune cells. Targeting glutamine metabolism in the TME is a promising strategy to improve anti-cancer therapy.
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Boosting glycolysis to combat fragile bone in type 1 diabetes Cell Chem. Bio. (IF 8.6) Pub Date : 2023-09-21 Zixue Jin, Brendan Lee
Individuals with type 1 diabetes (T1D) have an increased risk of osteoporosis and fracture. In this issue of Cell Chemical Biology, Ji et al.1 show that impaired glucose metabolism in the bone-forming osteoblast drives diabetic osteoporosis in Akita mice, a mouse model of T1D.
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Un-FASN-ing cancer’s seat belt: Linking lipid metabolism and antigen presentation Cell Chem. Bio. (IF 8.6) Pub Date : 2023-09-21 Zachary Corey, Elyse Schechter, Raphael A. Nemenoff
MHC-II expression on cancer cells is associated with improved treatment outcome. In this issue, Huang et al.1 report a panel of small molecules that selectively upregulate MHC-II on cancer cells through suppression of fatty acid synthase (FASN), resulting in inhibition of tumor growth. Targeting this link between lipid metabolism and antigen presentation may improve response to immunotherapy.
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Sabotaging the breaks: FSEN1 expands the toolbox of FSP1 inhibitors Cell Chem. Bio. (IF 8.6) Pub Date : 2023-09-21 Thamara Nishida Xavier da Silva, José Pedro Friedmann Angeli
The report of heightened lipid peroxidation has shone a spotlight on vulnerabilities within challenging cancers. In this context, FSP1 emerges as a pivotal regulator, actively countering the destructive effects of lipid peroxidation. In a groundbreaking development detailed in the latest issue of Cell Chemical Biology, Hendricks et al. unveil FSEN1, a potent inhibitor of FSP1. The discovery of FSEN1
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Repurposing SGLT2 inhibitors for autoimmune diseases? YES, WE MAY! Cell Chem. Bio. (IF 8.6) Pub Date : 2023-09-21 Michelangelo Certo, Jennifer Niven, Claudio Mauro
T cells play a key role in driving autoimmunity, with alterations in metabolism powering their effector function. In the July 11 issue of Cell Metabolism, Jenkins et al.1 describe how a type 2 diabetes drug, canagliflozin, can be repurposed for the treatment of autoimmune disorders through metabolic reprogramming of the T cell response.
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Metabolic modulation of mitochondrial mass during CD4+ T cell activation Cell Chem. Bio. (IF 8.6) Pub Date : 2023-09-15 Kiran Kurmi, Dan Liang, Robert van de Ven, Peter Georgiev, Brandon Mark Gassaway, SeongJun Han, Giulia Notarangelo, Isaac S. Harris, Cong-Hui Yao, Joon Seok Park, Song-Hua Hu, Jingyu Peng, Jefte M. Drijvers, Sarah Boswell, Artem Sokolov, Stephanie K. Dougan, Peter K. Sorger, Steven P. Gygi, Arlene H. Sharpe, Marcia C. Haigis
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Chemoproteomic strategy identified p120-catenin glutathionylation regulates E-cadherin degradation and cell migration Cell Chem. Bio. (IF 8.6) Pub Date : 2023-09-14 Dhanushika S.K. Kukulage, Maheeshi Yapa Abeywardana, Nadee N.J. Matarage Don, Ren-Ming Hu, Kyosuke Shishikura, Megan L. Matthews, Young-Hoon Ahn
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Metabolic and chemical architecture of the mammalian circadian clock Cell Chem. Bio. (IF 8.6) Pub Date : 2023-09-13 Isara Laothamatas, Emil Sjulstok Rasmussen, Carla B. Green, Joseph S. Takahashi
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Tumor microenvironmental nutrients, cellular responses, and cancer Cell Chem. Bio. (IF 8.6) Pub Date : 2023-09-12 Graham P. Lobel, Yanqing Jiang, M. Celeste Simon
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Screening in serum-derived medium reveals differential response to compounds targeting metabolism Cell Chem. Bio. (IF 8.6) Pub Date : 2023-09-08 Keene L. Abbott, Ahmed Ali, Dominick Casalena, Brian T. Do, Raphael Ferreira, Jaime H. Cheah, Christian K. Soule, Amy Deik, Tenzin Kunchok, Daniel R. Schmidt, Steffen Renner, Sophie E. Honeder, Michelle Wu, Sze Ham Chan, Tenzin Tseyang, Andrew T. Stoltzfus, Sarah L.J. Michel, Daniel Greaves, Peggy P. Hsu, Christopher W. Ng, Matthew G. Vander Heiden
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Profiling of drug resistance in Src kinase at scale uncovers a regulatory network coupling autoinhibition and catalytic domain dynamics Cell Chem. Bio. (IF 8.6) Pub Date : 2023-09-07 Sujata Chakraborty, Ethan Ahler, Jessica J. Simon, Linglan Fang, Zachary E. Potter, Katherine A. Sitko, Jason J. Stephany, Miklos Guttman, Douglas M. Fowler, Dustin J. Maly
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Structural basis of CD97 activation and G-protein coupling Cell Chem. Bio. (IF 8.6) Pub Date : 2023-09-05 Na Wang, Yu Qian, Ruixue Xia, Xinyan Zhu, Yangjie Xiong, Anqi Zhang, Changyou Guo, Yuanzheng He
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Target deconvolution with matrix-augmented pooling strategy reveals cell-specific drug-protein interactions Cell Chem. Bio. (IF 8.6) Pub Date : 2023-08-30 Hongchao Ji, Xue Lu, Shiji Zhao, Qiqi Wang, Bin Liao, Ludwig G. Bauer, Kilian V.M. Huber, Ray Luo, Ruijun Tian, Chris Soon Heng Tan
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Cannabidiol acts as molecular switch in innate immune cells to promote the biosynthesis of inflammation-resolving lipid mediators Cell Chem. Bio. (IF 8.6) Pub Date : 2023-08-29 Lukas K. Peltner, Lars Gluthmann, Friedemann Börner, Simona Pace, Robert K. Hoffstetter, Christian Kretzer, Rosella Bilancia, Federica Pollastro, Andreas Koeberle, Giovanni Appendino, Antonietta Rossi, Marcia E. Newcomer, Nathaniel C. Gilbert, Oliver Werz, Paul M. Jordan
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Protomer selectivity of type II RAF inhibitors within the RAS/RAF complex Cell Chem. Bio. (IF 8.6) Pub Date : 2023-08-28 James D. Vasta, Ani Michaud, Chad A. Zimprich, Michael T. Beck, Matthew R. Swiatnicki, Hicham Zegzouti, Morgan R. Thomas, Jennifer Wilkinson, J. Aaron Crapster, Matthew B. Robers
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Mechanism-based inhibition of gut microbial tryptophanases reduces serum indoxyl sulfate Cell Chem. Bio. (IF 8.6) Pub Date : 2023-08-25 Amanda L. Graboski, Mark E. Kowalewski, Joshua B. Simpson, Xufeng Cao, Mary Ha, Jianan Zhang, William G. Walton, Daniel P. Flaherty, Matthew R. Redinbo
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A split-luciferase lysate-based approach to identify small-molecule modulators of phosphatase subunit interactions Cell Chem. Bio. (IF 8.6) Pub Date : 2023-08-24 Zander Claes, Mathieu Bollen
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Succinylation of a KEAP1 sensor lysine promotes NRF2 activation Cell Chem. Bio. (IF 8.6) Pub Date : 2023-08-23 Lara Ibrahim, Caroline Stanton, Kayla Nutsch, Thu Nguyen, Chloris Li-Ma, Yeonjin Ko, Gabriel C. Lander, R. Luke Wiseman, Michael J. Bollong
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USP10 strikes down β-catenin by dual-wielding deubiquitinase activity and phase separation potential Cell Chem. Bio. (IF 8.6) Pub Date : 2023-08-22 Yinuo Wang, Aihua Mao, Jingwei Liu, Pengjie Li, Shaoqin Zheng, Tong Tong, Zexu Li, Haijiao Zhang, Lanjing Ma, Jiahui Lin, Zhongqiu Pang, Qing Han, Fukang Qi, Xinjun Zhang, Maorong Chen, Xi He, Xi Zhang, Teng Fei, Bi-Feng Liu, Daming Gao, Ren Sheng
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Inducible mismatch repair streamlines forward genetic approaches to target identification of cytotoxic small molecules Cell Chem. Bio. (IF 8.6) Pub Date : 2023-08-21 Thu P. Nguyen, Min Fang, Jiwoong Kim, Baiyun Wang, Elisa Lin, Vishal Khivansara, Neha Barrows, Giomar Rivera-Cancel, Maria Goralski, Christopher L. Cervantes, Shanhai Xie, Johann M. Peterson, Juan Manuel Povedano, Monika I. Antczak, Bruce A. Posner, Colin J.B. Harvey, Brian T. Naughton, David G. McFadden, Joseph M. Ready, Jef K. De Brabander, Deepak Nijhawan
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A non-rational approach to optimized targeting of CRISPR-Cas9 complexes Cell Chem. Bio. (IF 8.6) Pub Date : 2023-08-17 Brandon Wilbanks, Keenan Pearson, L. James Maher
In this issue of Cell Chemical Biology, Bush et al.1 report an in vitro selection method for optimizing CRISPR-Cas9 single-guide RNAs. This approach may be useful in targeting previously intractable genomic sequences. The results also provide insights into which positions in single-guide RNAs are most amenable to modification.
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Help! I need a WNT antibody. Help! Not just any antibody Cell Chem. Bio. (IF 8.6) Pub Date : 2023-08-17 Martti Maimets
The emergence of antibody based surrogate WNT molecules has revolutionized research exploiting organoid cultures. In this issue of Cell Chemical Biology, Post et al.1 present a refined collection of WNT mimetics with unprecedented WNT/β-catenin pathway activating characteristics. These mimetics hold significant promise for future therapeutic advancements.
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The dark side of circular RNA, a new driver of genome instability Cell Chem. Bio. (IF 8.6) Pub Date : 2023-08-17 Ajit Kumar Sharma, Anish Thomas
Circular RNAs (circRNAs) are covalently closed RNA molecules whose functions are still largely uncharacterized. In the July issue of Cancer Cell, Conn et al.1 demonstrate that circRNA can bind cognate DNA loci, forming circRNA-DNA hybrids (circR loops), driving genetic rearrangements of MLL/KMT2A, which are associated with the most aggressive acute leukemias.
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Identification of KLHDC2 as an efficient proximity-induced degrader of K-RAS, STK33, β-catenin, and FoxP3 Cell Chem. Bio. (IF 8.6) Pub Date : 2023-08-16 Sascha Röth, Nur Mehpare Kocaturk, Preethi S. Sathyamurthi, Bill Carton, Matthew Watt, Thomas J. Macartney, Kwok-Ho Chan, Albert Isidro-Llobet, Agnieszka Konopacka, Markus A. Queisser, Gopal P. Sapkota
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Multimodal, broadly neutralizing antibodies against SARS-CoV-2 identified by high-throughput native pairing of BCRs from bulk B cells Cell Chem. Bio. (IF 8.6) Pub Date : 2023-08-15 Gladys J. Keitany, Benjamin E.R. Rubin, Meghan E. Garrett, Andrea Musa, Jeff Tracy, Yu Liang, Peter Ebert, Amanda J. Moore, Jonathan Guan, Erica Eggers, Ninnia Lescano, Ryan Brown, Adria Carbo, Hussein Al-Asadi, Travers Ching, Austin Day, Rebecca Harris, Charles Linkem, Dimitry Popov, Courtney Wilkins, Amy E. Gilbert
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HDAC3 and HDAC8 PROTAC dual degrader reveals roles of histone acetylation in gene regulation Cell Chem. Bio. (IF 8.6) Pub Date : 2023-08-11 Yufeng Xiao, Seth Hale, Nikee Awasthee, Chengcheng Meng, Xuan Zhang, Yi Liu, Haocheng Ding, Zhiguang Huo, Dongwen Lv, Weizhou Zhang, Mei He, Guangrong Zheng, Daiqing Liao
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Mitochondria-targeted melatonin photorelease supports the presence of melatonin MT1 receptors in mitochondria inhibiting respiration Cell Chem. Bio. (IF 8.6) Pub Date : 2023-08-11 Gloria Somalo-Barranco, Antonio C. Pagano Zottola, Abdulrasheed O. Abdulrahman, Rami M. El Zein, Astrid Cannich, Lourdes Muñoz, Carme Serra, Atsuro Oishi, Giovanni Marsicano, Bernard Masri, Luigi Bellocchio, Amadeu Llebaria, Ralf Jockers
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Targeted kinase degradation via the KLHDC2 ubiquitin E3 ligase Cell Chem. Bio. (IF 8.6) Pub Date : 2023-08-10 Younghoon Kim, Pooreum Seo, Eunhye Jeon, Inchul You, Kyubin Hwang, Namkyoung Kim, Jason Tse, Juhyeon Bae, Ha-Soon Choi, Stephen M. Hinshaw, Nathanael S. Gray, Taebo Sim
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Genetic activation of glycolysis in osteoblasts preserves bone mass in type I diabetes Cell Chem. Bio. (IF 8.6) Pub Date : 2023-08-09 Xing Ji, Rebecca Seeley, Ke Li, Fangfang Song, Xueyang Liao, Chao Song, Marco Angelozzi, Arianna Valeri, Tyler Marmo, Wen-Chih Lee, Yu Shi, Fanxin Long
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Discovery of a highly potent, selective, orally bioavailable inhibitor of KAT6A/B histone acetyltransferases with efficacy against KAT6A-high ER+ breast cancer Cell Chem. Bio. (IF 8.6) Pub Date : 2023-08-08 Shikhar Sharma, Chi-Yeh Chung, Sean Uryu, Jelena Petrovic, Joan Cao, Amanda Rickard, Nataliya Nady, Samantha Greasley, Eric Johnson, Oleg Brodsky, Showkhin Khan, Hui Wang, Zhenxiong Wang, Yong Zhang, Konstantinos Tsaparikos, Lei Chen, Anthony Mazurek, John Lapek, Pei-Pei Kung, Scott Sutton, Thomas A. Paul
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Genetically incorporated crosslinkers identify regulators of membrane protein PD-L1 in mammalian cells Cell Chem. Bio. (IF 8.6) Pub Date : 2023-08-03 Fangni Chai, Pan Li, Yong He, Zhihui Zhou, Shupan Guo, Xin Liu, Li Zhou, Haiyan Ren
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Arabinose- and xylose-modified analogs of 2′,3′-cGAMP act as STING agonists Cell Chem. Bio. (IF 8.6) Pub Date : 2023-08-02 Wei Xie, Lodoe Lama, Xuejing Yang, Vitaly Kuryavyi, Shibani Bhattacharya, Ilona Nudelman, Guangli Yang, Ouathek Ouerfelli, J. Fraser Glickman, Roger A. Jones, Thomas Tuschl, Dinshaw J. Patel
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Small molecule targeting of transcription-replication conflict for selective chemotherapy Cell Chem. Bio. (IF 8.6) Pub Date : 2023-08-01 Long Gu, Min Li, Caroline M. Li, Pouya Haratipour, Robert Lingeman, Jennifer Jossart, Margarita Gutova, Linda Flores, Caitlyn Hyde, Nikola Kenjić, Haiqing Li, Vincent Chung, Hongzhi Li, Brett Lomenick, Daniel D. Von Hoff, Timothy W. Synold, Karen S. Aboody, Yilun Liu, David Horne, Robert J. Hickey, Linda H. Malkas
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Catalytic inhibitor of Protein Phosphatase 5 activates the extrinsic apoptotic pathway by disrupting complex II in kidney cancer Cell Chem. Bio. (IF 8.6) Pub Date : 2023-07-31 Elham F. Ahanin, Rebecca A. Sager, Sarah J. Backe, Diana M. Dunn, Natela Dushukyan, Adam R. Blanden, Nilamber A. Mate, Tamie Suzuki, Tyler Anderson, Merin Roy, Jasmeen Oberoi, Chrisostomos Prodromou, Imad Nsouli, Michael Daneshvar, Gennady Bratslavsky, Mark R. Woodford, Dimitra Bourboulia, John D. Chisholm, Mehdi Mollapour
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CLK2 and CLK4 are regulators of DNA damage-induced NF-κB targeted by novel small molecule inhibitors Cell Chem. Bio. (IF 8.6) Pub Date : 2023-07-27 Patrick Mucka, Peter Lindemann, Bartolomeo Bosco, Michael Willenbrock, Silke Radetzki, Martin Neuenschwander, Cristina Brischetto, Jens Peter von Kries, Marc Nazaré, Claus Scheidereit
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Paralog-dependent isogenic cell assay cascade generates highly selective SLC16A3 inhibitors Cell Chem. Bio. (IF 8.6) Pub Date : 2023-07-28 Vojtech Dvorak, Andrea Casiraghi, Claire Colas, Anna Koren, Tatjana Tomek, Fabian Offensperger, Andrea Rukavina, Gary Tin, Elisa Hahn, Sarah Dobner, Fabian Frommelt, Andras Boeszoermenyi, Viktoriia Bernada, J. Thomas Hannich, Gerhard F. Ecker, Georg E. Winter, Stefan Kubicek, Giulio Superti-Furga
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High-resolution photocatalytic mapping of SARS-CoV-2 spike interactions on the cell surface Cell Chem. Bio. (IF 8.6) Pub Date : 2023-07-26 Suprama Datta, Da-Yuan Chen, Alexander H. Tavares, Tamara Reyes-Robles, Keun Ah Ryu, Nazimuddin Khan, Tyler J. Bechtel, Jayde M. Bertoch, Cory H. White, Daria J. Hazuda, Kalpit A. Vora, Erik C. Hett, Olugbeminiyi O. Fadeyi, Rob C. Oslund, Andrew Emili, Mohsan Saeed
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The rise of degrader drugs Cell Chem. Bio. (IF 8.6) Pub Date : 2023-07-25 Mingxing Teng, Nathanael S. Gray
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DELs enable the development of BRET probes for target engagement studies in cells Cell Chem. Bio. (IF 8.6) Pub Date : 2023-07-24 Kelly A. Teske, Wenji Su, Cesear R. Corona, Jing Wen, Jason Deng, Yan Ping, Zaihong Zhang, Qi Zhang, Jennifer Wilkinson, Michael T. Beck, Kendra R. Nealey, James D. Vasta, Mei Cong, Poncho L. Meisenheimer, Letian Kuai, Matthew B. Robers
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TRIMming away colon cancer: TRIM21-mediated ubiquitination as an activator of the Hippo tumor suppressor pathway Cell Chem. Bio. (IF 8.6) Pub Date : 2023-07-20
In this issue of Cell Chemical Biology, Liu et al.1 identify TRIM21-mediated ubiquitination of the Hippo pathway kinase MST2, promoting its dimerization and activation. The antidepressant Vilazodone was found to bind to TRIM21, enhancing its activity toward MST2, increasing Hippo activation, and reducing colorectal cancer metastasis.
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Catalytic spike antibodies: A new paradigm in neutralization Cell Chem. Bio. (IF 8.6) Pub Date : 2023-07-20
In this issue, McConnell et al.10 demonstrate that COVID-19 convalescent plasma (CCP)-derived antibodies can neutralize SARS-CoV-2 by proteolytically cleaving the spike protein. The CCP antibody-mediated catalysis has broader implications beyond COVID-19 and can be applicable in understanding the mechanism of antibody-based neutralization of different pathogens.
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Targeting YTHDF2/MDSCs to improve radiotherapy Cell Chem. Bio. (IF 8.6) Pub Date : 2023-07-20
Immunosuppression contributes to tumor-radiotherapy failure, but the mechanism remains elusive. Wang et al.1 reported that ionizing radiation (IR) induces YTHDF2 expression in myeloid-derived suppressor cells (MDSCs) via an IR-YTHDF2-NF-κB circuit, which contributes to MDSC expansion/migration and treatment failure. Genetic depletion or pharmacological inhibition of YTHDF2 overcomes immunosuppression
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Purine-ifying uric acid by gut microbes Cell Chem. Bio. (IF 8.6) Pub Date : 2023-07-20
Elevated bloodstream levels of uric acid, a mammalian purine degradation product, are associated with several noncommunicable diseases. Recent studies by Kasahara et al. and Liu et al. define purine-degrading activities of the gut microbiota that lower bloodstream uric acid in atherosclerosis and gout disease models, establishing a novel microbial role in host health.
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S-Nitrosylation-mediated dysfunction of TCA cycle enzymes in synucleinopathy studied in postmortem human brains and hiPSC-derived neurons Cell Chem. Bio. (IF 8.6) Pub Date : 2023-07-20 Paschalis-Thomas Doulias, Hongmei Yang, Alexander Y. Andreyev, Nima Dolatabadi, Henry Scott, Charlene K Raspur, Parth R. Patel, Tomohiro Nakamura, Steven R. Tannenbaum, Harry Ischiropoulos, Stuart A. Lipton
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Hydroxyproline metabolism enhances IFN-γ-induced PD-L1 expression and inhibits autophagic flux Cell Chem. Bio. (IF 8.6) Pub Date : 2023-07-18 Stephan H. Spangenberg, Amelia Palermo, Nathalia R. Gazaniga, Francisco Martínez-Peña, Carlos Guijas, Emily N. Chin, Markus M. Rinschen, Philipp N. Sander, Bill Webb, Laura E. Pereira, Ying Jia, Lance Meitz, Gary Siuzdak, Luke L. Lairson
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Chemokine binding to PSGL-1 is controlled by O-glycosylation and tyrosine sulfation Cell Chem. Bio. (IF 8.6) Pub Date : 2023-07-17 Christoffer K. Goth, Akul Y. Mehta, Alyssa M. McQuillan, Kelly J. Baker, Melinda S. Hanes, Simon S. Park, Kathrin Stavenhagen, Gertrud M. Hjortø, Jamie Heimburg-Molinaro, Elliot L. Chaikof, Mette M. Rosenkilde, Richard D. Cummings
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Insulin sensitization by small molecules enhancing GLUT4 translocation Cell Chem. Bio. (IF 8.6) Pub Date : 2023-07-14 Terry C. Yin, Jonathan G. Van Vranken, Dhiraj Srivastava, Ayushi Mittal, Paul Buscaglia, Autumn E. Moore, Jissele A. Verdinez, Aschleigh E. Graham, Susan A. Walsh, Michael A. Acevedo, Robert J. Kerns, Nikolai O. Artemyev, Steven P. Gygi, Julien A. Sebag
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Genome- and metabolome-guided discovery of marine BamA inhibitors revealed a dedicated darobactin halogenase Cell Chem. Bio. (IF 8.6) Pub Date : 2023-07-13 Nils Böhringer, Jil-Christine Kramer, Eugenio de la Mora, Leo Padva, Zerlina G. Wuisan, Yang Liu, Michael Kurz, Michael Marner, Hai Nguyen, Patricia Amara, Kenichi Yokoyama, Yvain Nicolet, Ute Mettal, Till F. Schäberle
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Substrate-dependent interaction of SPOP and RACK1 aggravates cardiac fibrosis following myocardial infarction Cell Chem. Bio. (IF 8.6) Pub Date : 2023-07-12
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Integrating inflammatory biomarker analysis and artificial-intelligence-enabled image-based profiling to identify drug targets for intestinal fibrosis Cell Chem. Bio. (IF 8.6) Pub Date : 2023-07-11 Shan Yu, Alexandr A. Kalinin, Maria D. Paraskevopoulou, Marco Maruggi, Jie Cheng, Jie Tang, Ilknur Icke, Yi Luo, Qun Wei, Dan Scheibe, Joel Hunter, Shantanu Singh, Deborah Nguyen, Anne E. Carpenter, Shane R. Horman
Intestinal fibrosis, often caused by inflammatory bowel disease, can lead to intestinal stenosis and obstruction, but there are no approved treatments. Drug discovery has been hindered by the lack of screenable cellular phenotypes. To address this, we used a scalable image-based morphology assay called Cell Painting, augmented with machine learning algorithms, to identify small molecules that could
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Inhibition of nucleolar transcription by oxaliplatin involves ATM/ATR kinase signaling Cell Chem. Bio. (IF 8.6) Pub Date : 2023-07-10 Misha Nechay, Danyang Wang, Ralph E. Kleiner
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Integration of metabolism and regulation reveals rapid adaptability to growth on non-native substrates Cell Chem. Bio. (IF 8.6) Pub Date : 2023-07-07 Vikas D. Trivedi, Sean F. Sullivan, Debika Choudhury, Venkatesh Endalur Gopinarayanan, Taylor Hart, Nikhil U. Nair
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Proximity-labeling chemoproteomics defines the subcellular cysteinome and inflammation-responsive mitochondrial redoxome Cell Chem. Bio. (IF 8.6) Pub Date : 2023-07-06 Tianyang Yan, Ashley R. Julio, Miranda Villanueva, Anthony E. Jones, Andréa B. Ball, Lisa M. Boatner, Alexandra C. Turmon, Kaitlyn B. Nguyễn, Stephanie L. Yen, Heta S. Desai, Ajit S. Divakaruni, Keriann M. Backus
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Novel Frizzled-specific antibody-based Wnt mimetics and Wnt superagonists selectively activate WNT/β-catenin signaling in target tissues Cell Chem. Bio. (IF 8.6) Pub Date : 2023-07-05 Yorick Post, Archana Dilip, Liqin Xie, Asmiti Sura, Nicholas Suen, Jay Ye, Devin Mutha, Angela T. Liu, Huy Nguyen, Elizabeth Whisler, Darshini Shah, Shalaka Deshmukh, Navrose Dhaliwal, Ben Bauer, Eskedar Nigatu, Anh Diep, Tom Lopez, Tristan W. Fowler, Sung-Jin Lee, Chenggang Lu, Yang Li
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Utilizing directed evolution to interrogate and optimize CRISPR/Cas guide RNA scaffolds Cell Chem. Bio. (IF 8.6) Pub Date : 2023-06-29 Korie Bush, Giulia I. Corsi, Amy C. Yan, Keith Haynes, Juliana M. Layzer, Jonathan H. Zhou, Telmo Llanga, Jan Gorodkin, Bruce A. Sullenger
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Morphological subprofile analysis for bioactivity annotation of small molecules Cell Chem. Bio. (IF 8.6) Pub Date : 2023-06-28 Axel Pahl, Beate Schölermann, Philipp Lampe, Marion Rusch, Mark Dow, Christian Hedberg, Adam Nelson, Sonja Sievers, Herbert Waldmann, Slava Ziegler