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An oral tricyclic STING agonist suppresses tumor growth through remodeling of the immune microenvironment Cell Chem. Bio. (IF 6.6) Pub Date : 2025-02-03 Hong-Yi Zhao, Zhongwei Liu, Jinsong Tao, Shuai Mao, Meilin Wang, Miao He, Bo Wen, Wei Gao, Duxin Sun
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Engineering electrogenetic interfaces for mammalian cell control Cell Chem. Bio. (IF 6.6) Pub Date : 2025-01-28 Maysam Mansouri, Martin Fussenegger
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A genetically encoded fluorescent biosensor for visualization of acetyl-CoA in live cells Cell Chem. Bio. (IF 6.6) Pub Date : 2025-01-27 Joseph J. Smith, Taylor R. Valentino, Austin H. Ablicki, Riddhidev Banerjee, Adam R. Colligan, Debra M. Eckert, Gabrielle A. Desjardins, Katharine L. Diehl
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SynPull: An advanced method for studying neurodegeneration-related aggregates in synaptosomes using super-resolution microscopy Cell Chem. Bio. (IF 6.6) Pub Date : 2025-01-24 Shekhar Kedia, Emre Fertan, Yunzhao Wu, Yu P. Zhang, Georg Meisl, Jeff Y.L. Lam, Frances K. Wiseman, William A. McEwan, Annelies Quaegebeur, Maria Grazia Spillantini, John S.H. Danial, David Klenerman
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Meet the authors: Aayushi Uberoi and Elizabeth A. Grice Cell Chem. Bio. (IF 6.6) Pub Date : 2025-01-16 Aayushi Uberoi, Elizabeth A. Grice
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Meet the authors: Katerina Jones, Camila Bernardo de Brito, and Mariana Xavier Byndloss Cell Chem. Bio. (IF 6.6) Pub Date : 2025-01-16 Katerina Jones, Camila Bernardo de Brito, Mariana Xavier Byndloss
In an interview with Samantha Nelson, a scientific editor of Cell Chemical Biology, the authors of the review entitled “Metabolic tug-o-war: Microbial metabolism shapes colonization resistance against enteric pathogens” share their perspectives on the field and their lives as scientists.
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New opportunities in mechanistic and functional microbiome studies Cell Chem. Bio. (IF 6.6) Pub Date : 2025-01-16 Judith Behnsen, Kerwyn Casey Huang, Matthew T. Sorbara, Meng C. Wang, Jun Yu, Melody Y. Zeng
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Yeast paves the way for cancer immunotherapy Cell Chem. Bio. (IF 6.6) Pub Date : 2025-01-16 Dingjiacheng Jia, Shujie Chen
In this issue of Cell Chemical Biology, Rebeck et al.1 construct a system that enables Saccharomyces cerevisiae var. boulardii (Sb) to secrete immune checkpoint inhibitors, reducing intestinal tumor load. This safe and effective delivery platform using engineered yeast demonstrates potential for enhancing the efficacy of biologics.
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Metabolic tug-of-war: Microbial metabolism shapes colonization resistance against enteric pathogens Cell Chem. Bio. (IF 6.6) Pub Date : 2025-01-16 Katerina Jones, Camila Bernardo de Brito, Mariana Xavier Byndloss
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Commensal-derived tryptophan metabolites fortify the skin barrier: Insights from a 50-species gnotobiotic model of human skin microbiome Cell Chem. Bio. (IF 6.6) Pub Date : 2025-01-16 Aayushi Uberoi, Sofía M. Murga-Garrido, Preeti Bhanap, Amy E. Campbell, Simon A.B. Knight, Monica Wei, Anya Chan, Taylor Senay, Saba Tegegne, Ellen K. White, Carrie Hayes Sutter, Clementina Mesaros, Thomas R. Sutter, Elizabeth A. Grice
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A widespread and ancient bacterial machinery assembles cytochrome OmcS nanowires essential for extracellular electron transfer Cell Chem. Bio. (IF 6.6) Pub Date : 2025-01-15 Cong Shen, Aldo I. Salazar-Morales, Wonhyeuk Jung, Joey Erwin, Yangqi Gu, Anthony Coelho, Kallol Gupta, Sibel Ebru Yalcin, Fadel A. Samatey, Nikhil S. Malvankar
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Small molecules targeting selective PCK1 and PGC-1α lysine acetylation cause anti-diabetic action through increased lactate oxidation Cell Chem. Bio. (IF 6.6) Pub Date : 2025-01-15 Beste Mutlu, Kfir Sharabi, Jee Hyung Sohn, Bo Yuan, Pedro Latorre-Muro, Xin Qin, Jin-Seon Yook, Hua Lin, Deyang Yu, João Paulo G. Camporez, Shingo Kajimura, Gerald I. Shulman, Sheng Hui, Theodore M. Kamenecka, Patrick R. Griffin, Pere Puigserver
No Abstract
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Targeting N-Myc in neuroblastoma with selective Aurora kinase A degraders Cell Chem. Bio. (IF 6.6) Pub Date : 2025-01-07 Jian Tang, Ramkumar Moorthy, Laura E. Hirsch, Özlem Demir, Zachary D. Baker, Jordan A. Naumann, Katherine F.M. Jones, Michael J. Grillo, Ella S. Haefner, Ke Shi, Michaella J. Levy, Harshita B. Gupta, Hideki Aihara, Reuben S. Harris, Rommie E. Amaro, Nicholas M. Levinson, Daniel A. Harki
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The right tool for the job: Chemical biology and microbiome science Cell Chem. Bio. (IF 6.6) Pub Date : 2025-01-06 Christopher Whidbey
Microbiomes exist in ecological niches ranging from the ocean and soil to inside of larger organisms like plants and animals. Within these niches, microbes play key roles in biochemical processes that impact larger phenomena, such as biogeochemical cycling or health. By understanding of how these processes occur at the molecular level, it may be possible to develop new interventions to address global
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The efflux pump ABCC1/MRP1 constitutively restricts PROTAC sensitivity in cancer cells Cell Chem. Bio. (IF 6.6) Pub Date : 2025-01-03 Gernot Wolf, Conner Craigon, Shao Thing Teoh, Patrick Essletzbichler, Svenja Onstein, Diane Cassidy, Esther C.H. Uijttewaal, Vojtech Dvorak, Yuting Cao, Ariel Bensimon, Ulrich Elling, Alessio Ciulli, Giulio Superti-Furga
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Development of an FKBP12-recruiting chemical-induced proximity DNA-encoded library and its application to discover an autophagy potentiator Cell Chem. Bio. (IF 6.6) Pub Date : 2025-01-02 Zher Yin Tan, Joel K.A. Adade, Xiebin Gu, Cody J.S. Hecht, Michael Salcius, Bingqi Tong, Shuang Liu, Seungmin Hwang, Frédéric J. Zécri, Daniel B. Graham, Stuart L. Schreiber, Ramnik J. Xavier
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Calcineurin: An essential regulator of sleep revealed by biochemical, chemical biological, and genetic approaches Cell Chem. Bio. (IF 6.6) Pub Date : 2024-12-30 Jianjun Yu, Huijie Liu, Rui Gao, Tao V. Wang, Chenggang Li, Yuxiang Liu, Lu Yang, Ying Xu, Yunfeng Cui, Chenxi Jia, Juan Huang, Peng R. Chen, Yi Rao
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Discovery of a Pseudomonas aeruginosa-specific small molecule targeting outer membrane protein OprH-LPS interaction by a multiplexed screen Cell Chem. Bio. (IF 6.6) Pub Date : 2024-12-27 Bradley E. Poulsen, Thulasi Warrier, Sulyman Barkho, Josephine Bagnall, Keith P. Romano, Tiantian White, Xiao Yu, Tomohiko Kawate, Phuong H. Nguyen, Kyra Raines, Kristina Ferrara, A. Lorelei Golas, Michael FitzGerald, Andras Boeszoermenyi, Virendar Kaushik, Michael Serrano-Wu, Noam Shoresh, Deborah T. Hung
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Anti-tumor immunotherapy using engineered bacterial outer membrane vesicles fused to lysosome-targeting chimeras mediated by transferrin receptor Cell Chem. Bio. (IF 6.6) Pub Date : 2024-12-24 Ling-Yan Su, Yang Tian, Qiang Zheng, Yu Cao, Mengyu Yao, Shuangping Wang, Wen Xu, Chuyu Xi, Andrea Clocchiatti, Guangjun Nie, Hejiang Zhou
(Cell Chemical Biology 31, 1219–1230.e1–e5; June 20, 2024)
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D-aring to explore: New approaches to gasdermin D targeting Cell Chem. Bio. (IF 6.6) Pub Date : 2024-12-19 Lei Wang, Wen Zhou
Novel inhibitors of pyroptosis promise breakthroughs in treating inflammatory diseases and malignant tumors. In this issue of Cell Chemical Biology, Hu et al.1 identify two repurposed drugs that selectively target gasdermin D (GSDMD) oligomers, effectively suppressing pyroptosis while reducing off-target effects typical of cysteine-based inhibitors.
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FAAHcilitating recovery in malnourished kids Cell Chem. Bio. (IF 6.6) Pub Date : 2024-12-19 Franciscus Chandra, Elaine Y. Hsiao
The molecular underpinnings behind the diet-microbiome-host health relationship are largely undescribed. In a recent issue of Science, Cheng et al.1 uncovered one piece of the puzzle by describing a novel fatty acid amide hydrolase (FAAH) derived from a Faecalibacterium prausnitzii strain that correlated with improved malnutrition recovery. This emphasized the microbiome’s role in supporting recovery
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Macrophages make “sense” of obesity-driven acidity in the TME Cell Chem. Bio. (IF 6.6) Pub Date : 2024-12-19 Spenser H. Stone, Jeffrey C. Rathmell, Jackie E. Bader
Obesity is a leading risk factor and a negative prognostic indicator for many cancers. In a recent issue of Science Immunology, Bagchi et al. identified that tumor-associated macrophages upregulate GPR65 in response to obesity-driven intratumor acidity resulting in reduced effector function to promote tumor growth.1
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Biogenesis and roles of tRNA queuosine modification and its glycosylated derivatives in human health and diseases Cell Chem. Bio. (IF 6.6) Pub Date : 2024-12-09 Tsutomu Suzuki, Atsuya Ogizawa, Kensuke Ishiguro, Asuteka Nagao
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Insights into biofilm architecture and maturation enable improved clinical strategies for exopolysaccharide-targeting therapeutics Cell Chem. Bio. (IF 6.6) Pub Date : 2024-12-04 J. Sebastian Temme, Zibin Tan, Mi Li, Mo Yang, Alexander Wlodawer, Xuefei Huang, John S. Schneekloth Jr., Jeffrey C. Gildersleeve
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Platelets accelerate lipid peroxidation and induce pathogenic neutrophil extracellular trap release Cell Chem. Bio. (IF 6.6) Pub Date : 2024-12-03 Madoka Ono, Masayasu Toyomoto, Momono Yamauchi, Masatoshi Hagiwara
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β-hydroxybutyrate is a metabolic regulator of proteostasis in the aged and Alzheimer disease brain Cell Chem. Bio. (IF 6.6) Pub Date : 2024-12-02 Sidharth S. Madhavan, Stephanie Roa Diaz, Sawyer Peralta, Mitsunori Nomura, Christina D. King, Kaya E. Ceyhan, Anwen Lin, Dipa Bhaumik, Anna C. Foulger, Samah Shah, Thanh Blade, Wyatt Gray, Manish Chamoli, Brenda Eap, Oishika Panda, Diego Diaz, Thelma Y. Garcia, Brianna J. Stubbs, Scott M. Ulrich, Gordon J. Lithgow, Birgit Schilling, Eric Verdin, Asish R. Chaudhuri, John C. Newman
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An engineered cereblon optimized for high throughput screening and molecular glue discovery Cell Chem. Bio. (IF 6.6) Pub Date : 2024-11-27 Henry J. Bailey, Jonathan Eisert, Rubina Kazi, Jan Gerhartz, Dominika Ewa Pieńkowska, Ina Dressel, Joshua Vollrath, Ivan Kondratov, Tetiana Matviyuk, Nataliya Tolmachova, Varun Jayeshkumar Shah, Giulio Giuliani, Thorsten Mosler, Thomas M. Geiger, Ana M. Esteves, Sandra P. Santos, Raquel L. Sousa, Tiago M. Bandeiras, Eva-Maria Leibrock, Ulrike Bauer, Birgitta Leuthner, Julian D. Langer, Ansgar A. Wegener
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Therapeutic induction of ferroptosis in tumors using PD-L1 targeting antibody nanogel conjugates Cell Chem. Bio. (IF 6.6) Pub Date : 2024-11-26 Mengdie Wang, Theeraphop Prachyathipsakul, Christi A. Wisniewski, Choua Xiong, Shivam Goel, Hira Lal Goel, Emmet R. Karner, Dimpi Mukhopadhyay, Prachi Gupta, Aniket Majee, S. Thayumanavan, Arthur M. Mercurio
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Covalent targeting of splicing in T cells Cell Chem. Bio. (IF 6.6) Pub Date : 2024-11-25 Kevin A. Scott, Hiroyuki Kojima, Nathalie Ropek, Charles D. Warren, Tiffany L. Zhang, Simon J. Hogg, Henry Sanford, Caroline Webster, Xiaoyu Zhang, Jahan Rahman, Bruno Melillo, Benjamin F. Cravatt, Jiankun Lyu, Omar Abdel-Wahab, Ekaterina V. Vinogradova
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Decoding retrons: Breakthroughs in RT-DNA production and genome editing Cell Chem. Bio. (IF 6.6) Pub Date : 2024-11-21 Wenqian Liu, Yingjia Pan, Yu Zhang, Chang Dong, Lei Huang, Jiazhang Lian
Retrons are notable for their anti-phage defense functions and genome engineering applications. However, only a few retrons have been well characterized. In the August issue of Nature Biotechnology, Khan et al.1 present hundreds of experimentally studied retrons, which are critical for bacterial immunity research and retron-based genome engineering technologies.
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NAD reloaded: Hacking bacterial defenses Cell Chem. Bio. (IF 6.6) Pub Date : 2024-11-21 Arturo Carabias, Guillermo Montoya
Nicotinamide adenine dinucleotide (NAD) is an essential metabolite, and its depletion serves as a common bacterial immune strategy against bacteriophages (phages). In a recent issue of Nature, Osterman et al.1 reveal two phage-encoded NAD restoration pathways, showcasing the phages’ innovative counterstrategies against bacterial immunity and providing insights for developing novel antimicrobial approaches
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A yeast-based oral therapeutic delivers immune checkpoint inhibitors to reduce intestinal tumor burden Cell Chem. Bio. (IF 6.6) Pub Date : 2024-11-20 Olivia N. Rebeck, Miranda J. Wallace, Jerome Prusa, Jie Ning, Esse M. Evbuomwan, Sunaina Rengarajan, LeMoyne Habimana-Griffin, Suryang Kwak, David Zahrah, Jason Tung, James Liao, Bejan Mahmud, Skye R.S. Fishbein, Erick S. Ramirez Tovar, Rehan Mehta, Bin Wang, Mark G. Gorelik, Beth A. Helmink, Gautam Dantas
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Host specific sphingomyelin is critical for replication of diverse RNA viruses Cell Chem. Bio. (IF 6.6) Pub Date : 2024-11-19 Shuo Han, Xiaolei Ye, Jintong Yang, Xuefang Peng, Xiaming Jiang, Jin Li, Xiaojie Zheng, Xinchen Zhang, Yumin Zhang, Lingyu Zhang, Wei Wang, Jiaxin Li, Wenwen Xin, Xiaoai Zhang, Gengfu Xiao, Ke Peng, Leike Zhang, Xuguang Du, Lu Zhou, Wei Liu, Hao Li
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Chemical tools to expand the ligandable proteome: Diversity-oriented synthesis-based photoreactive stereoprobes Cell Chem. Bio. (IF 6.6) Pub Date : 2024-11-14 Daisuke Ogasawara, David B. Konrad, Zher Yin Tan, Kimberly L. Carey, Jessica Luo, Sang Joon Won, Haoxin Li, Trever R. Carter, Kristen E. DeMeester, Evert Njomen, Stuart L. Schreiber, Ramnik J. Xavier, Bruno Melillo, Benjamin F. Cravatt
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A PROTAC degrader suppresses oncogenic functions of PTK6 inducing apoptosis of breast cancer cells Cell Chem. Bio. (IF 6.6) Pub Date : 2024-11-13 Criseyda Martinez, Yan Xiong, Alison Bartkowski, Ibuki Harada, Xiaoxiao Ren, Jessica Byerly, Elisa Port, Jian Jin, Hanna Irie
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Degradome analysis to identify direct protein substrates of small-molecule degraders Cell Chem. Bio. (IF 6.6) Pub Date : 2024-11-12 Marco Jochem, Anna Schrempf, Lina-Marie Wagner, Dmitri Segal, Jose Cisneros, Amanda Ng, Georg E. Winter, Jeroen Krijgsveld
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Bioluminescence assay of lysine deacylase sirtuin activity Cell Chem. Bio. (IF 6.6) Pub Date : 2024-11-07 Alexandria N. Van Scoyk, Orlando Antelope, Donald E. Ayer, Randall T. Peterson, Anthony D. Pomicter, Shawn C. Owen, Michael W. Deininger
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Next steps for targeted protein degradation Cell Chem. Bio. (IF 6.6) Pub Date : 2024-11-04 Mackenzie W. Krone, Craig M. Crews
Targeted protein degradation (TPD) has greatly advanced as a therapeutic strategy in the past two decades, and we are on the cusp of rationally designed protein degraders reaching clinical approval. Offering pharmacological advantages relative to occupancy-driven protein inhibition, chemical methods for regulating biomolecular proximity have provided opportunities to tackle disease-related targets
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A LANA peptide inhibits tumor growth by inducing CHD4 protein cleavage and triggers cell death Cell Chem. Bio. (IF 6.6) Pub Date : 2024-11-01 Hiroki Miura, Kang-Hsin Wang, Tomoki Inagaki, Frank Chuang, Michiko Shimoda, Chie Izumiya, Tadashi Watanabe, Ryan R. Davis, Clifford G. Tepper, Somayeh Komaki, Ken-ichi Nakajima, Ashish Kumar, Yoshihiro Izumiya
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Identification of two repurposed drugs targeting GSDMD oligomerization interface I to block pyroptosis Cell Chem. Bio. (IF 6.6) Pub Date : 2024-10-31 Yingchao Hu, Honghui Li, Xiangyu Zhang, Yuxian Song, Jun Liu, Jie Pu, Shuang Wen, Hongyang Xu, Hongliang Xin, Bingwei Wang, Shuo Yang
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Dynamic sampling of a surveillance state enables DNA proofreading by Cas9 Cell Chem. Bio. (IF 6.6) Pub Date : 2024-10-28 Viviane S. De Paula, Abhinav Dubey, Haribabu Arthanari, Nikolaos G. Sgourakis
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The liquid lectin array detects compositional glycocalyx differences using multivalent DNA-encoded lectins on phage Cell Chem. Bio. (IF 6.6) Pub Date : 2024-10-24 Guilherme M. Lima, Zeinab Jame-Chenarboo, Mirat Sojitra, Susmita Sarkar, Eric J. Carpenter, Claire Y. Yang, Edward Schmidt, Justine Lai, Alexey Atrazhev, Danial Yazdan, Chuanhao Peng, Elizabeth A. Volker, Ray Ho, Gisele Monteiro, Raymond Lai, Lara K. Mahal, Matthew S. Macauley, Ratmir Derda
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Lipid availability influences ferroptosis sensitivity in cancer cells by regulating polyunsaturated fatty acid trafficking Cell Chem. Bio. (IF 6.6) Pub Date : 2024-10-22 Kelly H. Sokol, Cameron J. Lee, Thomas J. Rogers, Althea Waldhart, Abigail E. Ellis, Sahithi Madireddy, Samuel R. Daniels, Rachel (Rae) J. House, Xinyu Ye, Mary Olesnavich, Amy Johnson, Benjamin R. Furness, Ryan D. Sheldon, Evan C. Lien
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RNA infrastructure profiling illuminates transcriptome structure in crowded spaces Cell Chem. Bio. (IF 6.6) Pub Date : 2024-10-23 Lu Xiao, Linglan Fang, Wenrui Zhong, Eric T. Kool
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Quinoline-based compounds can inhibit diverse enzymes that act on DNA Cell Chem. Bio. (IF 6.6) Pub Date : 2024-10-21 Jujun Zhou, Qin Chen, Ren Ren, Jie Yang, Bigang Liu, John R. Horton, Caleb Chang, Chuxuan Li, Leora Maksoud, Yifei Yang, Dante Rotili, Abhinav K. Jain, Xing Zhang, Robert M. Blumenthal, Taiping Chen, Yang Gao, Sergio Valente, Antonello Mai, Xiaodong Cheng
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Inviting new connections with science with public art in Philadelphia Cell Chem. Bio. (IF 6.6) Pub Date : 2024-10-17 Sarah J. McAnulty
In this Stories piece, Sarah J. McAnulty, the executive director of Skype a Scientist and an assistant research professor at the University of Connecticut, discusses the importance of scientists connecting with their local communities to promote trust in and engagement with science.
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Uncovering lipid dynamics in Staphylococcus aureus osteomyelitis using multimodal imaging mass spectrometry Cell Chem. Bio. (IF 6.6) Pub Date : 2024-10-09 Christopher J. Good, Casey E. Butrico, Madeline E. Colley, Lauren N. Emmerson, Katherine N. Gibson-Corley, James E. Cassat, Jeffrey M. Spraggins, Richard M. Caprioli
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Reducing CRISPR-Cas9 off-target effects by optically controlled chemical modifications of guide RNA Cell Chem. Bio. (IF 6.6) Pub Date : 2024-10-08 Qianqian Qi, Xingyu Liu, Wei Xiong, Kaisong Zhang, Wei Shen, Yuanyuan Zhang, Xinyan Xu, Cheng Zhong, Yan Zhang, Tian Tian, Xiang Zhou
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Enhancer reprogramming underlies therapeutic utility of a SMARCA2 degrader in SMARCA4 mutant cancer Cell Chem. Bio. (IF 6.6) Pub Date : 2024-10-07 Sasikumar Kotagiri, Nicholas Blazanin, Yuanxin Xi, Yanyan Han, Md Qudratullah, Xiaobing Liang, Yawen Wang, Poonam Pandey, Hira Mazhar, Truong Nguyen Lam, Anand Kamal Singh, Jing Wang, Yonathan Lissanu
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A tau dephosphorylation-targeting chimera selectively recruits protein phosphatase-1 to ameliorate Alzheimer’s disease and tauopathies Cell Chem. Bio. (IF 6.6) Pub Date : 2024-09-30 Yue Xiao, Linyu Wei, Jingfen Su, Huiyang Lei, Fei Sun, Mengzhu Li, Shihong Li, Xiaochuan Wang, Jie Zheng, Jian-Zhi Wang
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Small molecules targeting selective PCK1 and PGC-1α lysine acetylation cause anti-diabetic action through increased lactate oxidation Cell Chem. Bio. (IF 6.6) Pub Date : 2024-09-27 Beste Mutlu, Kfir Sharabi, Jee Hyung Sohn, Bo Yuan, Pedro Latorre-Muro, Xin Qin, Jin-Seon Yook, Hua Lin, Deyang Yu, João Paulo G. Camporez, Shingo Kajimura, Gerald I. Shulman, Sheng Hui, Theodore M. Kamenecka, Patrick R. Griffin, Pere Puigserver
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Discovery and biosynthesis of non-canonical C16-terpenoids from Pseudomonas Cell Chem. Bio. (IF 6.6) Pub Date : 2024-09-26 Xu-Hua Mo, Qing-Yin Pu, Tilo Lübken, Gui-Hong Yu, Mert Malay, Paul M. D’Agostino, Tobias A.M. Gulder
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Mechanisms by which microbiome-derived metabolites exert their impacts on neurodegeneration Cell Chem. Bio. (IF 6.6) Pub Date : 2024-09-25 Lara Kern, Ignacio Mastandrea, Anna Melekhova, Eran Elinav
Recent developments in microbiome research suggest that the gut microbiome may remotely modulate central and peripheral neuronal processes, ranging from early brain development to age-related changes. Dysbiotic microbiome configurations have been increasingly associated with neurological disorders, such as neurodegeneration, but causal understanding of these associations remains limited. Most mechanisms
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RNA and condensates: Disease implications and therapeutic opportunities Cell Chem. Bio. (IF 6.6) Pub Date : 2024-09-19 Tina W. Han, Bede Portz, Richard A. Young, Ann Boija, Isaac A. Klein
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Reflections from advisory board members and associate editors Cell Chem. Bio. (IF 6.6) Pub Date : 2024-09-19 Michelle Arkin, Sara Buhrlage, Ling-Ling Chen, Peng Chen, Jason Gestwicki, Chuan He, Gerald F. Joyce, Angela Koehler, Milka Kostic, Jun Liu, Jim Wells
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What is chemical biology? Cell Chem. Bio. (IF 6.6) Pub Date : 2024-09-19 Albert A. Antolin, Yimon Aye, Liron Bar-Peled, Elena De Vita, Natavan Dudkina, Michael C. Jewett, Hannah Kiely-Collins, Ralph Mazitschek, Zhenrun Jerry Zhang
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The next Nobel Prize in chemistry or in physiology or medicine Cell Chem. Bio. (IF 6.6) Pub Date : 2024-09-19 Cigall Kadoch, Jason M. Sheltzer, Hang Yin
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Meet the authors: Lydia P. Tsamouri and Daniel A. Bachovchin Cell Chem. Bio. (IF 6.6) Pub Date : 2024-09-19 Lydia P. Tsamouri, Daniel A. Bachovchin
In an interview with Dr. Mishtu Dey, editor-in-chief of Cell Chemical Biology, the authors of the article entitled “The hydrophobicity of the CARD8 N-terminus tunes inflammasome activation” share their perspectives on the ways chemical biology enriches immunology research, the challenges and opportunities in the field, and their scientific career paths.
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Membrane remodeling via ubiquitin-mediated pathways Cell Chem. Bio. (IF 6.6) Pub Date : 2024-09-19 Anne-Claire Jacomin, Ivan Dikic
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Ligand discovery by activity-based protein profiling Cell Chem. Bio. (IF 6.6) Pub Date : 2024-09-19 Micah J. Niphakis, Benjamin F. Cravatt