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A genome-wide CRISPR-Cas9 screen identifies CENPJ as a host regulator of altered microtubule organization during Plasmodium liver infection Cell Chem. Bio. (IF 8.116) Pub Date : 2022-06-22 Kamalakannan Vijayan, Nadia Arang, Ling Wei, Robert Morrison, Rechel Geiger, K. Rachael Parks, Adam J. Lewis, Fred D. Mast, Alyse N. Douglass, Heather S. Kain, John D. Aitchison, Jarrod S. Johnson, Alan Aderem, Alexis Kaushansky
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Lenalidomide bypasses CD28 co-stimulation to reinstate PD-1 immunotherapy by activating Notch signaling Cell Chem. Bio. (IF 8.116) Pub Date : 2022-06-21 Chen-Lu Geng, Jun-Yi Chen, Tian-Yu Song, Jae Hyung Jung, Min Long, Min-Fang Song, Tong Ji, Byung Soh Min, Jin Gu Lee, Bo Peng, Yi-Sheng Pu, Hong-Jie Fan, Piliang Hao, Qi Zhou, Eui-Cheol Shin, Yong Cang
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Visualization of the dynamic interaction between nucleosomal histone H3K9 tri-methylation and HP1α chromodomain in living cells Cell Chem. Bio. (IF 8.116) Pub Date : 2022-06-20 Kazuki Sasaki, Michihiro Suzuki, Takeshi Sonoda, Tilman Schneider-Poetsch, Akihiro Ito, Motoki Takagi, Shinya Fujishiro, Yoshihiro Sohtome, Kosuke Dodo, Takashi Umehara, Hiroyuki Aburatani, Kazuo Shin-ya, Yoichi Nakao, Mikiko Sodeoka, Minoru Yoshida
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Identifying enhancers of innate immune signaling as broad-spectrum antivirals active against emerging viruses Cell Chem. Bio. (IF 8.116) Pub Date : 2022-06-20 Ghizlane Maarifi, Marie-France Martin, Abderezak Zebboudj, Aude Boulay, Pierre Nouaux, Juliette Fernandez, Justine Lagisquet, Dominique Garcin, Raphael Gaudin, Nathalie J. Arhel, Sébastien Nisole
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Evidence that HDAC7 acts as an epigenetic “reader” of AR acetylation through NCoR-HDAC3 dissociation Cell Chem. Bio. (IF 8.116) Pub Date : 2022-06-15 Yuchen Zhang, Rafael Andrade, Anthony A. Hanna, Mary Kay H. Pflum
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Generation of glycan-specific nanobodies Cell Chem. Bio. (IF 8.116) Pub Date : 2022-06-14 Sana Khan Khilji, Felix Goerdeler, Kristin Frensemeier, David Warschkau, Jost Lühle, Zeinab Fandi, Falko Schirmeister, Zhuo Angel Chen, Onur Turak, Alvaro Mallagaray, Stefan Boerno, Bernd Timmermann, Juri Rappsilber, Peter H. Seeberger, Oren Moscovitz
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A complex puzzle: Regulation of SLFN12 RNase activity by phosphorylation Cell Chem. Bio. (IF 8.116) Pub Date : 2022-06-16 Heidi Greulich
PDE3A-SLFN12 complex formation activates the SLFN12 RNase, but the biochemical details of RNase activation remain mysterious. In this issue of Cell Chemical Biology, Yan and colleagues report that two phosphoserines on SLFN12 are dephosphorylated in response to PDE3A binding, and this dephosphorylation is required for activation of the SLFN12 RNase.
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Clearing the air: Uniquely engaging furin as an approach to cystic fibrosis therapy Cell Chem. Bio. (IF 8.116) Pub Date : 2022-06-16 Digant Nayak, Elizabeth V. Wasmuth, Shaun K. Olsen
In this issue of Cell Chemical Biology, Douglas et al. describe a potent, specific, and cell-permeable furin inhibitor that interacts with a cryptic binding site to rescue hallmarks of cystic fibrosis in human ex vivo models. BOS-318 holds promise for development of therapeutics targeting an array of furin-dependent pathologies.
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Acylation probing of “generic” RNA libraries reveals critical influence of loop constraints on reactivity Cell Chem. Bio. (IF 8.116) Pub Date : 2022-06-02 Lu Xiao, Linglan Fang, Eric T. Kool
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Visualizing Staphylococcus aureus pathogenic membrane modification within the host infection environment by multimodal imaging mass spectrometry Cell Chem. Bio. (IF 8.116) Pub Date : 2022-06-01 William J. Perry, Caroline M. Grunenwald, Raf Van de Plas, James C. Witten, Daniel R. Martin, Suneel S. Apte, James E. Cassat, Gösta B. Pettersson, Richard M. Caprioli, Eric P. Skaar, Jeffrey M. Spraggins
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A direct high-throughput protein quantification strategy facilitates discovery and characterization of a celastrol-derived BRD4 degrader Cell Chem. Bio. (IF 8.116) Pub Date : 2022-05-31 N. Connor Payne, Semer Maksoud, Bakhos A. Tannous, Ralph Mazitschek
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Chemical strategies to understand and manipulate host-pathogen interactions Cell Chem. Bio. (IF 8.116) Pub Date : 2022-05-19 Bridget K. Wagner, Mishtu Dey
Abstract not available
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Multi-protein complexes as drug targets Cell Chem. Bio. (IF 8.116) Pub Date : 2022-05-19 Jason E. Gestwicki
The molecular chaperone DnaK, is an attractive drug target for treating mycobacterial infections. In this issue, Hosfelt, Richards, and colleagues applied a high-throughput screen and discovered inhibitors that disrupt cofactor-mediated activation of DnaK. These inhibitors can lower bacterial survival under stress and decrease resistance to key antibiotics.
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Integrating complex host-pathogen immune environments into S. aureus vaccine studies Cell Chem. Bio. (IF 8.116) Pub Date : 2022-05-19 Chih-Ming Tsai, Irshad A. Hajam, J.R. Caldera, George Y. Liu
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Integrated genomics and chemical biology herald an era of sophisticated antibacterial discovery, from defining essential genes to target elucidation Cell Chem. Bio. (IF 8.116) Pub Date : 2022-05-05 Thulasi Warrier, Keith P. Romano, Anne E. Clatworthy, Deborah T. Hung
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Control of host PTMs by intracellular bacteria: An opportunity toward novel anti-infective agents Cell Chem. Bio. (IF 8.116) Pub Date : 2022-05-04 Virginie Stévenin, Jacques Neefjes
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Antisense-mediated senseful regulation of orchestrated metabolic response Cell Chem. Bio. (IF 8.116) Pub Date : 2022-04-21 Umut Ozcan
Accumulation of fat in the liver predisposes affected individuals to a variety of diseases, yet the molecular mechanisms leading to steatosis still remain elusive. Matsushita et al. (2022) propose a novel mechanism that interconnects insulin resistance and fatty liver formation by an orchestrated regulation of Irs2 and its natural antisense transcript.
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New sheriff in town: Cyclic peptide inhibitors of a DUB module Cell Chem. Bio. (IF 8.116) Pub Date : 2022-04-21 Shamshad Alam, Boyko S. Atanassov
In this issue of Cell Chemical Biology, Morgan et al. (2021) show that cyclic peptides can be potent and highly specific inhibitors for deubiquitinating enzymes. This study identifies the first selective inhibitors of the cancer-associated ubiquitin-specific protease 22 (USP22).
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Lockdown, a selective small-molecule inhibitor of the integrin phosphatase PPM1F, blocks cancer cell invasion Cell Chem. Bio. (IF 8.116) Pub Date : 2022-04-19 Tanja M. Grimm, Marleen Herbinger, Lena Krüger, Silke Müller, Thomas U. Mayer, Christof R. Hauck
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Cellular signals converge at the NOX2-SHP-2 axis to induce reductive carboxylation in cancer cells Cell Chem. Bio. (IF 8.116) Pub Date : 2022-04-15 Rukang Zhang, Dong Chen, Hao Fan, Rong Wu, Jiayi Tu, Freya Q. Zhang, Mei Wang, Hong Zheng, Cheng-Kui Qu, Shannon E. Elf, Brandon Faubert, Yu-Ying He, Marc B. Bissonnette, Xue Gao, Ralph J. DeBerardinis, Jing Chen
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Chemical insights into flexizyme-mediated tRNA acylation Cell Chem. Bio. (IF 8.116) Pub Date : 2022-04-11 Jaime N. Coronado, Phuoc Ngo, Eric V. Anslyn, Andrew D. Ellington
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Inhibiting a dynamic viral protease by targeting a non-catalytic cysteine Cell Chem. Bio. (IF 8.116) Pub Date : 2022-03-31 Kaitlin R. Hulce, Priyadarshini Jaishankar, Gregory M. Lee, Markus-Frederik Bohn, Emily J. Connelly, Kristin Wucherer, Chayanid Ongpipattanakul, Regan F. Volk, Shih-Wei Chuo, Michelle R. Arkin, Adam R. Renslo, Charles S. Craik
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Glycopeptidolipid glycosylation controls surface properties and pathogenicity in Mycobacterium abscessus Cell Chem. Bio. (IF 8.116) Pub Date : 2022-03-30 Wassim Daher, Louis-David Leclercq, Matt D. Johansen, Claire Hamela, Jona Karam, Xavier Trivelli, Jérôme Nigou, Yann Guérardel, Laurent Kremer
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Small-molecule HIV-1 entry inhibitors targeting the epitopes of broadly neutralizing antibodies Cell Chem. Bio. (IF 8.116) Pub Date : 2022-03-29 Shibo Jiang, Alexander Tuzikov, Alexander Andrianov
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A selective PPM1A inhibitor activates autophagy to restrict the survival of Mycobacterium tuberculosis Cell Chem. Bio. (IF 8.116) Pub Date : 2022-03-22 Stefania Berton, Lu Chen, Yi Chu Liang, Zhongliang Xu, Afrakoma Afriyie-Asante, Nusrah Rajabalee, Weibo Yang, Jim Sun
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A phospholipid mimetic targeting LRH-1 ameliorates colitis Cell Chem. Bio. (IF 8.116) Pub Date : 2022-03-21 Suzanne G. Mays, Emma H. D’Agostino, Autumn R. Flynn, Xiangsheng Huang, Guohui Wang, Xu Liu, Elizabeth J. Millings, C. Denise Okafor, Anamika Patel, Michael L. Cato, Jeffery L. Cornelison, Diana Melchers, René Houtman, David D. Moore, John W. Calvert, Nathan T. Jui, Eric A. Ortlund
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Inhibiting GLUTtony in cancer Cell Chem. Bio. (IF 8.116) Pub Date : 2022-03-17 Sarah M. Chang, Matthew G. Vander Heiden
In this issue of Cell Chemical Biology, Olszewski et al. (2022) address the challenge of developing small molecules to inhibit glucose uptake in cancer. They characterize a novel pan-GLUT inhibitor that suppresses tumor growth and uncover how cancer cells can adapt to glucose restriction.
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Degradation of NSD3: What to Myc of it all? Cell Chem. Bio. (IF 8.116) Pub Date : 2022-03-17 Adam I. Green, George M. Burslem
Preventing uncontrolled gene expression is a powerful therapeutic strategy for the treatment of cancers. In this issue of Cell Chemical Biology, Xu et al. (2022) describe a series of proteolysis targeting chimeras that induce the degradation of NSD3 and suppress cMyc-related oncogene transcription in a model of acute myeloid leukemia.
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Using chemical biology for targeting cancer. Cell Chem. Bio. (IF 8.116) Pub Date : 2022-03-17 Mishtu Dey
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Resolving the deceptive isoform and complex selectivity of HDAC1/2 inhibitors Cell Chem. Bio. (IF 8.116) Pub Date : 2022-03-16 N. Connor Payne, Ralph Mazitschek
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Rheb regulates nuclear mTORC1 activity independent of farnesylation Cell Chem. Bio. (IF 8.116) Pub Date : 2022-03-15 Yanghao Zhong, Xin Zhou, Kun-Liang Guan, Jin Zhang
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A Pseudomonas aeruginosa PQS quorum-sensing system inhibitor with anti-staphylococcal activity sensitizes polymicrobial biofilms to tobramycin Cell Chem. Bio. (IF 8.116) Pub Date : 2022-03-07 Ewan J. Murray, Jean-Frédéric Dubern, Weng C. Chan, Siri Ram Chhabra, Paul Williams
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Metabolic incorporation of electron-rich ribonucleosides enhances APEX-seq for profiling spatially restricted nascent transcriptome Cell Chem. Bio. (IF 8.116) Pub Date : 2022-03-03 Ran Li, Zhongyu Zou, Wentao Wang, Peng Zou
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Resurfaced ZIKV EDIII nanoparticle immunogens elicit neutralizing and protective responses in vivo Cell Chem. Bio. (IF 8.116) Pub Date : 2022-02-28 George I. Georgiev, Ryan J. Malonis, Ariel S. Wirchnianski, Alex W. Wessel, Helen S. Jung, Sean M. Cahill, Elisabeth K. Nyakatura, Olivia Vergnolle, Kimberly A. Dowd, David Cowburn, Theodore C. Pierson, Michael S. Diamond, Jonathan R. Lai
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A highly selective, cell-permeable furin inhibitor BOS-318 rescues key features of cystic fibrosis airway disease Cell Chem. Bio. (IF 8.116) Pub Date : 2022-02-23 Lisa E.J. Douglas, James A. Reihill, Melisa W.Y. Ho, Jeffrey M. Axten, Nino Campobasso, Jessica L. Schneck, Alan R. Rendina, Keith M. Wilcoxen, S. Lorraine Martin
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Two birds, one stone: Non-canonical therapeutic effects of the PARP inhibitor Talazoparib Cell Chem. Bio. (IF 8.116) Pub Date : 2022-02-17 Sridevi Challa, W. Lee Kraus
In this issue of Cell Chemical Biology, Palve et al. (2022) identified PARP16 as a non-canonical therapeutic target of the PARP1 inhibitor talazoparib, which synergizes with the WEE1 inhibitor adavosertib to enhance its efficacy. The dual targeting of PARP1 and PARP16 may explain the greater efficacy of talazoparib in some cancers.
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No acetyl-CoA keeps Plasmodium at bay Cell Chem. Bio. (IF 8.116) Pub Date : 2022-02-17 Victoria Jeffers, Matthew A. Child
Acetyl-coenzyme A is an important metabolite and regulates diverse cellular processes, including metabolism and epigenetics. In this issue of Cell Chemical Biology, Summers et al. (2022) describe an essential parasite enzyme, acetyl-coenzyme A synthetase, as a target of two antimalarial small molecules active against liver and blood stages of the parasite.
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Phosphorylation of guanosine monophosphate reductase triggers a GTP-dependent switch from pro- to anti-oncogenic function of EPHA4 Cell Chem. Bio. (IF 8.116) Pub Date : 2022-02-10 David W. Wolff, Zhiyong Deng, Anna Bianchi-Smiraglia, Colleen E. Foley, Zhannan Han, Xingyou Wang, Shichen Shen, Masha M. Rosenberg, Sudha Moparthy, Dong Hyun Yun, Jialin Chen, Brian K. Baker, Matthew V. Roll, Andrew J. Magiera, Jun Li, Edward Hurley, Maria Laura Feltri, Anderson O. Cox, Mikhail A. Nikiforov
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Identification of an endoplasmic reticulum proteostasis modulator that enhances insulin production in pancreatic β cells Cell Chem. Bio. (IF 8.116) Pub Date : 2022-02-09 Masato Miyake, Mitsuaki Sobajima, Kiyoe Kurahashi, Akira Shigenaga, Masaya Denda, Akira Otaka, Tomohide Saio, Naoki Sakane, Hidetaka Kosako, Seiichi Oyadomari
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Generation of an anticoagulant aptamer that targets factor V/Va and disrupts the FVa-membrane interaction in normal and COVID-19 patient samples Cell Chem. Bio. (IF 8.116) Pub Date : 2022-02-02 Erin E. Soule, Haixiang Yu, Lyra Olson, Ibtehaj Naqvi, Shekhar Kumar, Sriram Krishnaswamy, Bruce A. Sullenger
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Selective vulnerabilities in the proteostasis network of castration-resistant prostate cancer Cell Chem. Bio. (IF 8.116) Pub Date : 2022-02-01 Arielle Shkedi, Isabelle R. Taylor, Frank Echtenkamp, Poornima Ramkumar, Mohamed Alshalalfa, Génesis M. Rivera-Márquez, Michael A. Moses, Hao Shao, Robert Jeffrey Karnes, Len Neckers, Felix Feng, Martin Kampmann, Jason E. Gestwicki
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Identifying and antagonizing the interactions between layilin and glycosylated collagens Cell Chem. Bio. (IF 8.116) Pub Date : 2022-02-01 Jeff E. Glasgow, James R. Byrnes, Susannah D. Barbee, Joshua M. Moreau, Michael D. Rosenblum, James A. Wells
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Motif-dependent immune co-receptor interactome profiling by photoaffinity chemical proteomics Cell Chem. Bio. (IF 8.116) Pub Date : 2022-01-31 Xiong Chen, Shanping Ji, Zheyi Liu, Xiao Yuan, Congsheng Xu, Ruxi Qi, An He, Heng Zhao, Haiping Song, Chunlei Xiao, Weina Gao, Peng R. Chen, Ray Luo, Pengfei Li, Fangjun Wang, Xueming Yang, Ruijun Tian
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Multiple PDE3A modulators act as molecular glues promoting PDE3A-SLFN12 interaction and induce SLFN12 dephosphorylation and cell death Cell Chem. Bio. (IF 8.116) Pub Date : 2022-01-31 Bo Yan, Zhangcheng Ding, Wenbin Zhang, Gaihong Cai, Hui Han, Yan Ma, Yang Cao, Jiawen Wang, She Chen, Youwei Ai
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Small-molecule inhibitors of ferrochelatase are antiangiogenic agents Cell Chem. Bio. (IF 8.116) Pub Date : 2022-01-31 Kamakshi Sishtla, Nathan Lambert-Cheatham, Bit Lee, Duk Hee Han, Jaehui Park, Sheik Pran Babu Sardar Pasha, Sanha Lee, Sangil Kwon, Anbukkarasi Muniyandi, Bomina Park, Noa Odell, Sydney Waller, Il Yeong Park, Soo Jae Lee, Seung-Yong Seo, Timothy W. Corson
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Ligand-induced interactions between butyrophilin 2A1 and 3A1 internal domains in the HMBPP receptor complex Cell Chem. Bio. (IF 8.116) Pub Date : 2022-01-25 Chia-Hung Christine Hsiao, Khiem Nguyen, Yiming Jin, Olga Vinogradova, Andrew J. Wiemer
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Excited to see you: New imaging approaches to detect ferrous iron in vivo Cell Chem. Bio. (IF 8.116) Pub Date : 2022-01-20 Joan Ritho, Scott J. Dixon
Ferroptosis is an iron-dependent form of cell death implicated in cancer and neurodegenerative diseases. In this issue of Cell Chemical Biology, Shao et al. (2022) and Wang et al. (2022) describe imaging techniques to monitor ferrous iron levels and iron-dependent lipid peroxidation, two key determinants of ferroptosis sensitivity.
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3D two-photon brain imaging reveals dihydroartemisinin exerts antiepileptic effects by modulating iron homeostasis Cell Chem. Bio. (IF 8.116) Pub Date : 2021-12-21 Chenwen Shao, Yani Liu, Zhangpeng Chen, Yajuan Qin, Xueao Wang, Xueting Wang, Chao Yan, Hai-Liang Zhu, Jing Zhao, Yong Qian
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PALP: A rapid imaging technique for stratifying ferroptosis sensitivity in normal and tumor tissues in situ Cell Chem. Bio. (IF 8.116) Pub Date : 2021-11-22 Fengxiang Wang, Emily T. Graham, Nathchar Naowarojna, Zhennan Shi, Yuqi Wang, Guanglei Xie, Lili Zhou, Wendy Salmon, Jie-Min Jia, Xi Wang, Yuwei Huang, Stuart L. Schreiber, Yilong Zou
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A collection of chemical biology strategies for visualization in live cells. Cell Chem. Bio. (IF 8.116) Pub Date : 2022-01-20 Mishtu Dey
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Acriflavine, a clinically approved drug, inhibits SARS-CoV-2 and other betacoronaviruses Cell Chem. Bio. (IF 8.116) Pub Date : 2022-01-11 Valeria Napolitano, Agnieszka Dabrowska, Kenji Schorpp, André Mourão, Emilia Barreto-Duran, Malgorzata Benedyk, Pawel Botwina, Stefanie Brandner, Mark Bostock, Yuliya Chykunova, Anna Czarna, Grzegorz Dubin, Tony Fröhlich, Michael Hölscher, Malwina Jedrysik, Alex Matsuda, Katarzyna Owczarek, Magdalena Pachota, Krzysztof Pyrc
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Increased energy demand from anabolic-catabolic processes drives β-lactam antibiotic lethality Cell Chem. Bio. (IF 8.116) Pub Date : 2022-01-05 Michael A. Lobritz, Ian W. Andrews, Dana Braff, Caroline B.M. Porter, Arnaud Gutierrez, Yoshikazu Furuta, Louis B.G. Cortes, Thomas Ferrante, Sarah C. Bening, Felix Wong, Charley Gruber, Christopher W. Bakerlee, Guillaume Lambert, Graham C. Walker, Daniel J. Dwyer, James J. Collins
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An antisense transcript transcribed from Irs2 locus contributes to the pathogenesis of hepatic steatosis in insulin resistance Cell Chem. Bio. (IF 8.116) Pub Date : 2022-01-04 Maya Matsushita, Motoharu Awazawa, Naoki Kobayashi, Yoshiko Matsumoto Ikushima, Kotaro Soeda, Miwa Tamura-Nakano, Masafumi Muratani, Kenta Kobayashi, Matthias Blüher, Jens C. Brüning, Kohjiro Ueki
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Morphological profiling by means of the Cell Painting assay enables identification of tubulin-targeting compounds Cell Chem. Bio. (IF 8.116) Pub Date : 2021-12-29 Mohammad Akbarzadeh, Ilka Deipenwisch, Beate Schoelermann, Axel Pahl, Sonja Sievers, Slava Ziegler, Herbert Waldmann
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Chemoselective restoration of para-azido-phenylalanine at multiple sites in proteins Cell Chem. Bio. (IF 8.116) Pub Date : 2021-12-28 Pol Arranz-Gibert, Koen Vanderschuren, Adrian Haimovich, Anushka Halder, Kallol Gupta, Jesse Rinehart, Farren J. Isaacs
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Differential effects of modified batrachotoxins on voltage-gated sodium channel fast and slow inactivation Cell Chem. Bio. (IF 8.116) Pub Date : 2021-12-27 Tim M.G. MacKenzie, Fayal Abderemane-Ali, Catherine E. Garrison, Daniel L. Minor, J. Du Bois
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Potent macrocycle inhibitors of the human SAGA deubiquitinating module Cell Chem. Bio. (IF 8.116) Pub Date : 2021-12-21 Michael Morgan, Tatsuya Ikenoue, Hiroaki Suga, Cynthia Wolberger
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Identification of small molecules that strongly inhibit bacterial quorum sensing using a high-throughput lipid vesicle lysis assay Cell Chem. Bio. (IF 8.116) Pub Date : 2021-12-20 Thomas J. Polaske, Curran G. Gahan, Kayleigh E. Nyffeler, David M. Lynn, Helen E. Blackwell
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Making the cut with protease engineering Cell Chem. Bio. (IF 8.116) Pub Date : 2021-12-17 Rebekah P. Dyer, Gregory A. Weiss
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Early DNA damage detection and cellular autophagy as drivers of stress-adaptive H2S production: A paradox resolved Cell Chem. Bio. (IF 8.116) Pub Date : 2021-12-16 Christopher Hine, Derek A. Wainwright, Justin D. Lathia
Appropriately responding and adapting to genotoxic, oxidative, and metabolic stress is essential for survival and is at the heart of maintaining homeostasis. In this issue of Cell Chemical Biology, Jiang et al. (2021) describe an autophagy-dependent mechanism for cytoprotective H2S generation initiated by DNA damage and other small molecule treatments.