Hydrogen-bonded organic framework (HOF) materials have provided a new dimension and bright promise as a new platform for developing multifunctional materials. They can be readily self-assembled from their corresponding organic molecules with diverse functional sites such as carboxylic acid and amine groups for their hydrogen bonding and aromatic ones for their weak π···π interactions to stabilize the

In a chemical equilibrium, the formation of high-energy species – in a closed system – is inefficient due to microscopic reversibility. Here, we demonstrate how this restriction can be circumvented by coupling a dynamic equilibrium to a light-induced E/Z isomerization of an azobenzene imine cage. The stable E-cage resists intermolecular imine exchange reactions that would “open” it. Upon switching

A lyophilized preparation of an unspecific peroxygenase variant from Agrocybe aegerita (rAaeUPO-PaDa-I-H) is a highly effective catalyst for the oxygenation of a diverse range of N-heterocyclic compounds. Scalable biocatalytic oxygenations (27 preparative examples, ≈100 mgs scale) have been developed across a wide range of substrates, including alkyl pyridines, bicyclic N-heterocycles and indoles.

The CRISPR/Cas system is one of the most powerful tools for gene editing. However, approaches for precise control of genome editing and regulatory events are still desirable. Here, we report a spatiotemporal and efficient control of CRISPR/Cas9- and Cas12a-mediated editing with conformational restricted gRNAs. This approach relied on only two or three pre-installed photo-labile substituents followed

To solve the problems such as the dissolution and the poor conductivity of organic small molecule electrode materials, we construct π-d conjugated coordination polymer Ni-DHBQ with multiple redox-active centers as lithium storage materials. It exhibits an ultra-high capacity of 9-electron transfers, while the π-d conjugation and the laminar structure inside the crystal ensure fast electron transport

Dearomatization reactions involving radical cyclizations can facilitate the synthesis of complex polycyclic systems that find applications in medicinal chemistry and natural product synthesis. Here we employ redox-neutral photocatalysis to affect a radical spirocyclization that transforms biaryls into spirocyclic cyclohexadienones under mild reaction conditions. In a departure from previously reported

The tethering of inorganic particle surfaces with organic ligands serves as a common technique for heterogenizing organometallic catalysts. We describe how the coordination of molecular platinum to high density norbornene-functionalized silica nanoparticles results in an unexpected latency of the catalytic activity (2% conversion after 60 min) in hydrosilylation reactions when compared to an identical

Imine-linked covalent organic frameworks (COFs) have been extensively studied in photocatalysis because of their easy synthesis and excellent crystallinity. The effect of imine bond orientation on the photocatalytic properties of COFs, however, is still rarely studied. In this work, we reported two novel COFs with different orientations of imine bonds using oligo(phenylenevinylene) moieties. The COFs

Selective activation of the C(sp3)-H bond is an important process in organic synthesis, where efficiently activating a specific C(sp3)-H bond without causing side reactions remains one of chemistry’s great challenges. Here we report that illuminated plasmonic silver metal nanoparticles (NPs) can abstract hydrogen from the C(sp3)-H bond of the Cα atom of an alkyl aryl ether β-O-4 linkage. The intense

The applications of alloy-type anode materials for Na-ion batteries are always obstructed by enormous volume variation upon cycles. Here, K+ ions are introduced as an electrolyte additive to improve the electrochemical performance via electrostatic shielding, using Sn microparticles (μ-Sn) as a model. Theoretical calculations and experimental results indicate that K+ ions are not incorporated in the

The electrochemical CO2 reduction reaction (CO2RR) to produce high value-added hydrocarbons and oxygenates presents a sustainable and compelling approach toward a carbon-neutral society. However, uncontrollable migration of active sites during the electrochemical CO2RR limits its catalytic ability to simultaneously achieve high C2 selectivity and ultradurability. Here, we demonstrate that the generated

Amines featuring an adjacent stereocenter are important building blocks, and recent years have seen remarkable growth in methods forming these via prochiral α-amino radical intermediates. However, very few can exert control over the newly formed stereocenter. We disclose a strategy to overcome this in the context of one of the most widely used radical carbon–carbon bond forming reactions, the Giese

Paired electrolysis methods are appealing for chemical synthesis because they generate valuable products at both electrodes; however, development of such reactions is complicated by the need for both half-reactions to proceed under mutually compatible conditions. Here, a modular electrochemical synthesis (ModES) strategy bypasses these constraints using a “redox reservoir” (RR) to pair electrochemical

Metal oxides have been used as the supports for heterogeneous catalysis for many years, but they still suffer from coking in some high-temperature applications. The main reasons for coking are the uncontrollable dissociation of C–H and the overbalance between carbon deposition and removal. Herein, we find a boron nitride (BN)-immobilized Ni catalyst shows unprecedented coking resistance in dry reforming

Programmes to avoid deforestation could have unintentional impacts on a variety of ecosystems.

A fifth fundamental force predicted by some alternative theories of gravity has not been seen in the solar interior.

How to choose a workplace that is welcoming and safe, and where your career will thrive.

Pleasure sensations are blunted in male rodents whose mums ate fatty food during pregnancy.