In this study, B(C6F5)3‐catalyzed reductive CC bond cleavage of bisindolylmethanes (BIMs) is reported as an efficient strategy for preparing C3‐alkylated indoles. In the presence of silane, B(C6F5)3 selectively activates Csp2‐Csp3 bonds of BIMs under mild conditions. Moreover, this sustainable process exhibits a broad substrate scope, highly functional group tolerance, and excellent regioselectivity

γ‐Carboline and γ‐carbolinone are privileged structural scaffolds for the development of new pharmaceuticals and functional materials. A concise and effective synthesis of carbocycle‐fused γ‐carbolinone derivatives via the regio‐ and chemoselective cascade reactions of indole‐3‐carboxamides with cyclic diazo compounds is presented. The formation of product is initiated by the regioselective C2H bond

A straightforward synthesis of spirolactones from carbonyls via N‐tosylhydrazones is described. The process consist in the reaction between the N‐tosylhydrazone and ethoxycarbonylethylboronic acid or ethoxycarbonylpropylboronic acid, leading to spiro γ‐butyrolactones or δ‐valerolactones respectively. The transformation takes place by carboborylation of the N‐tosylhydrazone followed by oxidation of

The hitherto few explored α‐halomethyl amidine motif has been assembled through the addition of a lithiated (di)‐halomethane (i.e. carbenoid) to easily accessible N,N’‐diaryl substituted carbodiimides. Despite the inherent low electrophilicity of these heterocumulenes – as quantitatively determined in Mayr’s previous studies – their sp‐hybridized carbon atom acts as a competent site of attack for these

In recent years, the use of electrochemistry has emerged as a powerful yet sustainable means of enabling key transformations. Amidation is one of the most frequently executed transformations in synthetic chemistry, and using an electrochemical approach, the current study has demonstrated the synthesis of amides from aldehydes and amines. Mechanistic work indicates that the reaction proceeds via the