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Advances in Transition‐Metal Catalyzed Carbonylative Suzuki‐Miyaura Coupling Reaction: An Update Adv. Synth. Catal. (IF 5.851) Pub Date : 2021-01-25 Dhananjay Bhattacherjee; Matiur Rahman; Sumit Ghosh; Avik Bagdi; Grigory Zyryanov; Oleg Chupakhin; Pralay Das; Alakananda Hajra
Transition metals have been an indispensable component of modern catalysis and among these palladium is the top‐ranked choice of chemists as catalyst. After the several important developments of palladium catalysed C‐C cross‐coupling reactions, carbonylative transformations have been realised as an attractive post modification of these reactions. Carbonylative Suzuki‐Miyaura coupling reaction is among
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Direct Carboxylation with Carbon Dioxide via Cooperative Photoredox and Transition‐Metal Dual Catalysis Adv. Synth. Catal. (IF 5.851) Pub Date : 2021-01-24 Guodong Zhang; Yihan Cheng; matthias Beller; Feng Chen
The utilization of carbon dioxide as a building block in organic synthesis has become a highly sought‐after research area. In this minireview, an overview of recent advances on carboxylations using carbon dioxide via visible light photoredox and transition‐metal dual catalysis is given. The merging of these methods provides new avenues to construct carboxylates.
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High‐level production of phenylacetaldehyde using fusion‐tagged styrene oxide isomerase Adv. Synth. Catal. (IF 5.851) Pub Date : 2021-01-24 Joel Ping Syong Choo; Richard Kammerer; Xiaodan Li; Zhi Li
An order‐of‐magnitude improvement in the production of phenylacetaldehyde to 3.37 M (405 g L‐1) from the enzymatic isomerisation of styrene oxide was achieved. A small ubiquitin‐related modifier (SUMO) tag increases the productivity of the whole‐cell biocatalytic system by enhancing the expression of active membrane‐bound styrene oxide isomerase (SOI) while retaining enzyme catalytic efficiency and
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Rh(III)‐Catalyzed Csp2‐Csp3 Bond Cleavage/Carbonylethylation of α‐Indolyl Alcohols Adv. Synth. Catal. (IF 5.851) Pub Date : 2021-01-22 Wei Zeng; Zhipeng Liu; Xinwei Hu; Can Yang; Haisheng Xie; Huanfeng Jiang
A Rh(III)‐catalyzed Csp2‐Csp3 bond cleavage/carbonylethylation of α‐indolyl alcohols with allylic alcohols has been reported. This transformation involved a cascade C‐C bond cleavage/C‐C bond formation, and provides a novel approach to assemble 2‐carbonylethylindole skeletons.
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Recent Developments in Remote meta‐C‐H Bond Functionalizations Adv. Synth. Catal. (IF 5.851) Pub Date : 2021-01-22 Rashid Ali; RAFIA SIDDIQUI
In the past decades, there has been a dramatic increase in the developments of novel methods for the activation/functionalization of inert C–H bonds as these protocols are not only competent, reduce the waste materials in addition to the reaction time and multiple steps but also allows the reaction to be carried out in a highly regio‐specific manner under operationally simple yet effective reaction
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Visible‐Light‐Induced Three‐Component Intermolecular Trifluoromethyl‐Alkenylation Reactions of Unactivated Alkenes Adv. Synth. Catal. (IF 5.851) Pub Date : 2021-01-22 Qing-Min Wang; Yuan-Qiang Guo; Kaihua Wang; Rui-Guo Wang; Hongjian Song; Yuxiu Liu
Herein, we describe a practical protocol for efficient, mild, visible‐light‐induced three‐component intermolecular trifluoromethyl‐alkenylation reactions of unactivated alkenes. The protocol has good functional group tolerance and a broad substrate scope. Using this protocol, we not only introduced a trifluoromethyl group into alkenes but also converted unactivated alkenes to styrene‐based activated
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Synthesis of Oxazolidinones by a Hypervalent Iodine Mediated Cyclization of N‐Allylcarbamates Adv. Synth. Catal. (IF 5.851) Pub Date : 2021-01-22 Mirdyul Das; Arantxa Rodríguez; Pui Lo; Wesley Moran
The preparation of oxazolidinones by the hypervalent iodine mediated cyclization of allylcarbamates is described. A versatile range of substrates can be converted into substituted oxazolidinones primed for further transformations. Derivatization of the products at both ends is demonstrated. A preliminary attempt at the enantioselective formation of an oxazolidinone using a chiral iodane is also presented
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Practical Synthesis of α‐Trifluoromethylated Pyridines Based on Regioselective Cobalt‐Catalyzed [2+2+2] Cycloaddition using Trifluoromethylated Diynes with Nitriles Adv. Synth. Catal. (IF 5.851) Pub Date : 2021-01-22 Tatsuya Kumon; Shigeyuki Yamada; Tomohiro Agou; Hiroki Fukumoto; Toshio Kubota; Gerald B. Hammond; Tsutomu Konno
Regioselective cobalt‐catalyzed [2+2+2] cycloaddition using fluorine‐containing diynes with nitriles was described. Cycloaddition of fluorinated diynes with nitriles under the influence of CoCl2(phen), zinc bromide, and zinc dust in dichloroethane at 80 °C for 3 h took place smoothly, exclusively affording the corresponding α‐fluoroalkylated pyridines in excellent yields. In addition, dinitriles as
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Efficient and clean nickel catalyzed α‐allylation reaction of nitriles Adv. Synth. Catal. (IF 5.851) Pub Date : 2021-01-22 Bouchaib Mouhsine; Abdallah Karim; Clément Dumont; Isabelle Suisse; Mathieu Sauthier
Abstract. A clean method has been developed for the α‐allylation of phenyl and alpha alkyl phenyl acetonitrile with allylic alcohols. The reaction is catalyzed by nickel complexes in situ generated from a combination of Ni(cod)2 and the dppf ligand and performed at 80°C in methanol as reaction solvent. Accordingly to this simple and base‐free protocol that only yields water as a side‐product, many
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Recent Progress in Palladium‐Catalyzed Radical Reactions Adv. Synth. Catal. (IF 5.851) Pub Date : 2021-01-22 Xi Sun; Xu Dong; Hui Liu; Yuying Liu
In recent years, great improvements have been made on palladium‐catalyzed radical reactions. Emerging elegant methodologies of radical involved palladium‐catalyzed transformations provide more and more effective strategies for the construction of complex heterocyclic compounds and applications in drug discovery. It is universally known that Pd(0)/(II)/(IV)‐mediated reactions usually undergo two‐electron
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Visible Light‐Promoted Selenylation/Cyclization of Enaminones toward the Formation of 3‐Selanyl‐4H‐chromen‐4‐ones Adv. Synth. Catal. (IF 5.851) Pub Date : 2021-01-22 Hao-Yang Liu; Jia-Rong Zhang; Guo-bao Huang; Yi-Huan Zhou; Yan-yan Chen; Yanli Xu
A simple and efficient visible‐light‐promoted selenylation/cyclization of enaminones have been realized for the practical synthesis of 3‐selanyl‐4H‐chromen‐4‐ones. This reaction is performed in the mild conditions, no transition metal catalyst or photocatalysts and no additional oxidants are required. In addition, the 3‐selanyl‐4H‐chromen‐4‐ones could be easily converted to selanyl‐functionalized pyrimidines
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Use of Imidazo[1,5‐a]pyridin‐3‐ylidene as a Platform for Metal‐Imidazole Cooperative Catalysis: Silver‐Catalyzed Cyclization of Alkyne‐Tethered Carboxylic Acids Adv. Synth. Catal. (IF 5.851) Pub Date : 2021-01-21 Vishal Kumar Rawat; Kosuke Higashida; Masaya Sawamura
Silver complexes with 5‐(4‐(tert‐butyl)‐1(H‐imidazol‐1‐yl)‐imidazo[1,5‐a]pyridin‐3‐ylidene ligands were synthesized as metal‐imidazole acid‐base cooperative catalysts. Single crystal XRD analysis revealed that the silver atom was located in the vicinity of the imidazole ring and that cationic silver complexes formed dimers through coordination between the silver metal and the imidazole pendant. These
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Catalytic Asymmetric aza‐Diels–Alder Reaction: Pivotal Milestones and Recent Applications to Synthesis of Nitrogen‐Containing Heterocycles Adv. Synth. Catal. (IF 5.851) Pub Date : 2021-01-21 Sergei Zlotin; Maxim G. Vinogradov; Olga V. Turova
In this review, the pivotal achievements and recent advances in catalytic asymmetric aza‐DAR reported up to 2020 are retrospectively considered and their potency for enantioselective synthesis of useful chiral piperidine, quinoline, pyridazine, oxazine and oxadiazine derivatives and fused compounds of higher molecular complexity bearing these pharmacology‐relevant heterocyclic scaffolds is demonstrated
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Zirconium Oxide‐Catalyzed Direct Amidation of Unactivated Esters under Continuous‐Flow Conditions Adv. Synth. Catal. (IF 5.851) Pub Date : 2021-01-22 Md. Nurnobi Rashed; Koichiro Masuda; Tomohiro Ichitsuka; Nagatoshi Koumura; Kazuhiko Sato; Shū Kobayashi
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Liquid‐Assisted Grinding Mechanochemistry in the Synthesis of Pharmaceuticals Adv. Synth. Catal. (IF 5.851) Pub Date : 2021-01-20 Ping Ying; Jingbo Yu; Weike Su
Mechanochemical reactions by milling, grinding or other types of mechanical action have emerged as a salient green approach because of its wide applications towards academic and industrial chemical communities in sustainable solvent‐free/solvent‐less processes. Liquid‐assisted grinding (LAG) as an extension of traditional solvent‐free mechanochemical techniques by which a small amount of liquid is
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Unravelling the C‐H arylation of benzo‐fused cycloalkanones: combined experimental and computational evidence Adv. Synth. Catal. (IF 5.851) Pub Date : 2021-01-20 Benjamin Large; Damien PRIM
The C‐H functionalization of benzo‐fused cycloalkanones represents a synthetic challenge since such scaffolds display different activation sites, at sp2 and sp3 carbons, a bicyclic structure and various sizes of the cycloalkanone ring. Anticipating the outcome of C‐H functionalisation and the impact of the presence and size of the cycloalkanone ring would help to foresee synthetic routes to more complex
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Visible‐Light‐Induced Controlled Oxidation of N‐Substituted 1,2,3,4‐Tetrahydroisoquinolines for the Synthesis of 3,4‐Dihydroisoquinolin‐1(2H)‐ones and Isoquinolin‐1(2H)‐ones Adv. Synth. Catal. (IF 5.851) Pub Date : 2021-01-21 Ajay H. Bansode; Gurunath Suryavanshi
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Palladium‐Catalyzed Carbonylation in the Synthesis of N‐Ynonylsulfoximines Adv. Synth. Catal. (IF 5.851) Pub Date : 2021-01-14 Ding Ma; Chenyang Wang; Deshen Kong; Yongliang Tu; Peng Shi; Carsten Bolm
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Bifunctional Ru‐loaded Porous Organic Polymers with Pyridine Functionality: Recyclable Catalysts for N‐Formylation of Amines with CO2 and H2 Adv. Synth. Catal. (IF 5.851) Pub Date : 2021-01-14 Kai Zhang; Lingbo Zong; Xiaofei Jia
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A Cascade Rh(III)‐catalyzed C−H Activation/Chemodivergent Annulation of N‐carbamoylindoles with Sulfoxonium Ylides for the Synthesis of Dihydropyrimidoindolone and Tricyclic [1,3]Oxazino[3,4‐a]indol‐1‐ones Derivatives Adv. Synth. Catal. (IF 5.851) Pub Date : 2021-01-21 Hui Xie; Mei Zhong; Hua‐Jie Kang; Bing Shu; Shang‐Shi Zhang
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1,2‐Benzothiazine Derivatives from Sulfonimidamides by Metal‐Catalyzed Annulation Reactions in Solution and under Solvent‐Free Mechanochemical Conditions Adv. Synth. Catal. (IF 5.851) Pub Date : 2021-01-14 Jan‐Hendrik Schöbel; Philipp Elbers; Khai‐Nghi Truong; Kari Rissanen; Carsten Bolm
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Visible‐Light‐Promoted Switchable Synthesis of C‐3‐Functionalized Quinoxalin‐2(1H)‐ones Adv. Synth. Catal. (IF 5.851) Pub Date : 2021-01-13 Kim Christopher C. Aganda; Boseok Hong; Anna Lee
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Recent Trends and Prospects in Homogeneous Manganese‐Catalysed Epoxidation Adv. Synth. Catal. (IF 5.851) Pub Date : 2021-01-20 Rose Mary Philip; Sankaran Radhika; C. M. Afsina Abdulla; Gopinathan Anilkumar
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Catalytic Approach to Diverse α‐Aminoboronic Acid Derivatives by Iridium‐Catalyzed Hydrogenation of Trifluoroborate‐Iminiums Adv. Synth. Catal. (IF 5.851) Pub Date : 2021-01-21 Andrej Šterman; Janez Košmrlj; Nina Žigart; Stanislav Gobec; Izidor Sosič; Zdenko Časar
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Cross‐Coupling Reactions of Aryl Halides with Primary and Secondary Aliphatic Alcohols Catalyzed by an O,N,N‐Coordinated Nickel Complex Adv. Synth. Catal. (IF 5.851) Pub Date : 2021-01-21 Toru Hashimoto; Keisuke Shiota; Kei Funatsu; Yoshitaka Yamaguchi
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Palladium‐Catalyzed Hydroarylation of Homopropargyl Iodoindoles with Concurrent Alkyl and Iodonium Migrations Adv. Synth. Catal. (IF 5.851) Pub Date : 2021-01-19 Pedro Almendros; Irene Martín; Cristina Aragoncillo
A selective palladium‐catalyzed C(sp) arylation/carbocyclization/iodonium migration reaction sequence has been accomplished. Novel 2‐iodo‐1‐aryl‐9H‐carbazoles are now easily available. As this result is contrary to the selectivity observed using gold catalysis, the formation of 2‐iodo‐carbazoles is noticeable, suggesting a metal‐controlled cyclization through chemo‐ and regioselective 1,2‐alkyl migration
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Recent Trends in the Synthesis and Mechanistic Implications of Phenanthridines Adv. Synth. Catal. (IF 5.851) Pub Date : 2021-01-19 Vishal Talukdar; Ajesh Vijayan; Naresh Kumar Katari; K. V. Radhakrishnan; Parthasarathi Das
Phenanthridine derivatives are one of the most intensively studied families of biologically active compounds. There has been considerable scientific interest in the turn of this century in the synthesis of these N‐containing heterocycles as they are prevalent in many alkaloids and also possess striking biological activities including antibacterial, antifungal, antitumor activities. In this regard,
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Construction of N‐Boc‐2‐Alkylaminoquinazolin‐4(3H)‐ones via a Three‐Component, One‐Pot Protocol Mediated by Copper(II) Chloride that Spares Enantiomeric Purity Adv. Synth. Catal. (IF 5.851) Pub Date : 2021-01-19 Xiaoyu Li; Jennifer Golden
Chiral 2‐alkylquinazolinones are key synthetic intermediates, but their preparation in high optical purity is challenging. Thus, a multicomponent procedure integrating anthranilic acids, N‐Boc‐amino acids, and amines in the presence of methanesulfonyl chloride, N‐methylimidazole, and copper(II) chloride was developed to mildly afford N‐Boc‐2‐alkylaminoquinazolin‐4(3H)‐ones with excellent preservation
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Recent Advances in the Synthesis of Heterocyclics via Cascade Cyclization of Propargylic Alcohols Adv. Synth. Catal. (IF 5.851) Pub Date : 2021-01-20 Xian‐Rong Song; Ruchun Yang; Qiang Xiao
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Formal [3+2] Cycloaddition Between in situ Formed 1,4‐Benzodiazepin‐2‐One‐Based Azomethine Ylides and Azodicarboxylic Acid Derivatives: Diastereoselective Synthesis of Spiro‐1,4‐Benzodiazepin‐2‐Ones Adv. Synth. Catal. (IF 5.851) Pub Date : 2021-01-13 Xiao‐Zu Fan; Hui‐Hui Wu; Zhe Tang; Heng Zhang; Lu‐Yu Cai; Xiao‐Fan Bi; Hong‐Wu Zhao
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Zinc‐Catalyzed Asymmetric Hydrosilylation of Cyclic Imines Adv. Synth. Catal. (IF 5.851) Pub Date : 2021-01-20 Izabela Węglarz; Karol Michalak; Jacek Mlynarski
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Regioselective Synthesis of 2,3‐Dihydrobenzo[f]isoindolones via Ag‐Catalyzed Sequential Ugi 4CR/Cascade Radical Cyclization Reaction Adv. Synth. Catal. (IF 5.851) Pub Date : 2021-01-13 Ying‐Chun He; Yan‐Mei Yan; Zhen‐Xing Ren; Yong‐Zhao Wang; Qiang Yu; Jun Xiong; Meng‐Liang Wang
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Recent Developments in Z‐Selective Olefin Metathesis Reactions by Molybdenum, Tungsten, Ruthenium, and Vanadium Catalysts Adv. Synth. Catal. (IF 5.851) Pub Date : 2021-01-20 Kamal M. Dawood; Kotohiro Nomura
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Recent Advances in Cross‐Dehydrogenative Couplings (CDC) of C‐H Bond in Aqueous Media Adv. Synth. Catal. (IF 5.851) Pub Date : 2021-01-18 Zhi-Bing Dong; Kang Peng
To develop highly efficient synthetic reactions is quite important in organic chemistry. Cross dehydrogenative couplings (CDC) utilize C‐H bonds of substrates to construct new C‐X (X=C, S, O, N, P) bonds. For CDC, the pre‐functionalization of reaction substrates can be avoided and the C‐X (X=C, S, O, N, P) bonds can be newly formed by simple and efficient synthesis routes. Meanwhile, water is increasingly
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Palladium‐Catalyzed Carbonylative Synthesis of 2‐(Trifluoromethyl)quinazolin‐4(3H)‐ones from Trifluoroacetimidoyl Chlorides and Nitro Compounds Adv. Synth. Catal. (IF 5.851) Pub Date : 2021-01-18 Xiao-Feng Wu; Zhengkai Chen; Le-Cheng Wang; yu zhang
A palladium‐catalyzed carbonylative reaction of trifluoroacetimidoyl chlorides and nitro compounds for the construction of pharmaceutically valuable 2‐(trifluoromethyl)quinazolin‐4(3H)‐ones has been achieved. In this transformation, Mo(CO)6 is regarded as both a convenient CO source and a reducing reagent. This newly developed protocol can be compatible with various kinds of nitro compounds and be
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Boron Reagents and Catalysts for the Functionalization of Strained Heterocycles Adv. Synth. Catal. (IF 5.851) Pub Date : 2021-01-18 MAURO PINESCHI
The particular nature of boron compounds allows an ample modularity of their properties ranging from Lewis acids, C‐nucleophiles, B‐nucleophiles or even conjunctive reagents for new synthetic manipulations. Moreover, the increasing demand for functionalized boron derivatives for pharmaceutical or material science applications requires the development of new synthetic methods for boron introduction
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Catalyst and Additive‐Free Selective Ring‐Opening Selenocyanation of Heterocycles with Elemental Selenium and TMSCN Adv. Synth. Catal. (IF 5.851) Pub Date : 2021-01-18 Li-Guo Lu; Kang Bi; Xiaobo Huang; Miaochang Liu; Yun-Bing Zhou; Huayue Wu
A catalyst and additive‐free strategy for selective ring‐opening selenocyanation of saturated heterocycles with elemental selenium and TMSCN is developed, affording a series of aliphatic selenocyanates and selenaheterocycles. In the case of unprotected unstrained N‐heterocycles, the reactions offer ammonium selenonitriles that prove to be an efficient selenonitrile reagent.
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Synthesis of Difluorinated Dihydrobenzo[de]chromenes via Rh(III)‐Catalysed C‐H Couplings of 1‐Naphthols with gem‐Difluoromethylene Alkynes Adv. Synth. Catal. (IF 5.851) Pub Date : 2021-01-18 Liping Li; Xiuhua Zhong; Jiali Xu; Hui Gao; Zhi Zhou; Wei Yi
The Rh(III)‐catalysed C‐H couplings of 1‐naphthols with gem‐difluoromethylene alkynes have been realized for the direct construction of difluorinated dihydrobenzo[de]chromenes with broad substrate/functional group compatibility and good regio‐/chemoselectivity and in an atom‐economic manner. The unique fluorine effects account for the unconventional reaction path involving intramolecular 1,3‐hydrogen
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Front Cover Picture: Copper‐Catalyzed Synthesis of α‐Trifluoromethylacrylates from Trifluoroborylacrylates via Stereoretentive Radical Trifluoromethylation (Adv. Synth. Catal. 2/2021) Adv. Synth. Catal. (IF 5.851) Pub Date : 2020-12-10 Swetha Jos; Webster L. Santos
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Halohydrin Dehalogenases and Their Potential in Industrial Application – A Viewpoint of Enzyme Reaction Engineering Adv. Synth. Catal. (IF 5.851) Pub Date : 2020-11-17 Zvjezdana Findrik Blažević; Nevena Milčić; Martina Sudar; Maja Majerić Elenkov
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Organic Azides: Versatile Synthons in Transition Metal‐Catalyzed C(sp2)−H Amination/Annulation for N‐Heterocycle Synthesis Adv. Synth. Catal. (IF 5.851) Pub Date : 2020-11-14 Zi‐Kui Liu; Quan‐Qing Zhao; Yang Gao; Ye‐Xing Hou; Xiao‐Qiang Hu
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P(III)‐Mediated Cascade C‐N/C‐S Bond Formation: A Protocol towards the Synthesis of N,S‐Heterocycles and Spiro Compounds Adv. Synth. Catal. (IF 5.851) Pub Date : 2020-11-20 Saibabu Polina; V. P. Rama Kishore Putta; Raghuram Gujjarappa; Virender Singh; Prasad Pralhad Pujar; Chandi C. Malakar
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Selective Synthesis of Fused Tricyclic [1,3]oxazino[3,4‐a]indolone and Dihydropyrimido [1,6‐a]indolone via Rh(III)‐catalyzed [3+3] or [4+2] C−H Annulation Adv. Synth. Catal. (IF 5.851) Pub Date : 2020-12-01 Junyu Chen; Tianshuo Zhong; Xiangyun Zheng; Chuanliu Yin; Lei Zhang; Jian Zhou; Xinpeng Jiang; Chuanming Yu
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Ruthenium Catalyzed Regioselective β‐C(sp3)−H Functionalization of N‐Alkyl‐N′‐p–nitrophenyl Substituted Piperazines using Aldehydes as Alkylating Agents Adv. Synth. Catal. (IF 5.851) Pub Date : 2020-12-01 V. Murugesh; Apurba Ranjan Sahoo; Mathieu Achard; Gangavaram V. M. Sharma; Christian Bruneau; Surisetti Suresh
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Strategy to Construct 1,2,3‐Triazoles by K2CO3‐Mediated [4+1] Annulation Reactions of N‐Acetyl Hydrazones with Bifunctional Amino Reagents Adv. Synth. Catal. (IF 5.851) Pub Date : 2020-11-30 Xiaoke Zhang; Yang Pan; Haibo Wang; Chong Liang; Xiaofeng Ma; Wei Jiao; Huawu Shao
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Electrochemical Regioselective Phosphorylation of Nitrogen‐Containing Heterocycles and Related Derivatives Adv. Synth. Catal. (IF 5.851) Pub Date : 2020-12-04 Yong Deng; Shiqi You; Mengyao Ruan; Ying Wang; Zuxing Chen; Guichun Yang; Meng Gao
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Gold‐Catalyzed Bicyclic and [3+2]‐Annulations of Internal Propargyl Alcohols with Nitrones and Imines To Yield to Two Distinct Heterocycles Adv. Synth. Catal. (IF 5.851) Pub Date : 2020-11-10 Sayaji Arjun More; Tzu‐Hsuan Chao; Mu‐Jeng Cheng; Rai‐Shung Liu
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Lewis Acid Catalyzed Reductive Cyclization of 2‐Aryloxybenzaldehydes and 2‐(Arylthio)benzaldehydes to Unsubstituted 9H‐Xanthenes and Thioxanthenes in Diisopropyl Ether Adv. Synth. Catal. (IF 5.851) Pub Date : 2020-11-10 Shashi Kant Verma; Anamika Prajapati; Manoj Kumar Saini; Ashok K. Basak
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Development of an Enzymatic Process for the Synthesis of the Key Intermediate of Telotristat Ethyl Adv. Synth. Catal. (IF 5.851) Pub Date : 2020-11-16 Hengyu Li; Wenhe Zhang; Xianyan Jiang; Huibin Wang; Qi Wang; Jiajun Wang; Xian Jia; Bin Qin; Song You
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A Concise Route to 2‐Sulfonylacetonitriles from Sodium Metabisulfite Adv. Synth. Catal. (IF 5.851) Pub Date : 2020-11-25 Yanfang Yao; Ziqing Yin; Weiyun Chen; Wenlin Xie; Fu‐Sheng He; Jie Wu
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Metal‐Free, Multicomponent Anti‐Markovnikov Hydroarylsulfonylation and Alkoxyarylsulfonylation of Vinyl Arenes Adv. Synth. Catal. (IF 5.851) Pub Date : 2020-11-25 Pritha Das; Subhodeep Das; Kasarla Varalaxmi; Ranjan Jana
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Asymmetric Oxidative Mannich Reactions Adv. Synth. Catal. (IF 5.851) Pub Date : 2021-01-18 Jaume Rostoll‐Berenguer; Gonzalo Blay; José R. Pedro; Carlos Vila
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Salicylic Acid‐Promoted Three‐Component Annulation of Benzimidazoles, Nitroalkenes and Elemental Sulfur Adv. Synth. Catal. (IF 5.851) Pub Date : 2021-01-15 Ruhuai Mei; Chenrui Yang; Feng Xiong; Jinwu Zhao
Herein, a three‐component reaction of benzimidazoles, nitroalkenes and elemental sulfur has been developed. Cheap and easily available salicylic acid found to be an efficient mediator for the present transformation. This protocol provides facile access to structurally significant imidazo[2,1‐b]thiazole skeleton from simple raw materials, with a range of compatible synthetically useful functionalities
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Dearomatization and Functionalization of Aromatic Rings via η3‐Benzyl Palladium Intermediates Adv. Synth. Catal. (IF 5.851) Pub Date : 2021-01-14 Sheng Zhang; Yoshinori Yamamoto; Ming Bao
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Transition‐metal‐free base‐controlled C‐N coupling reactions: Selective mono versus diarylation of primary amines with 2‐chlorobenzimidazoles Adv. Synth. Catal. (IF 5.851) Pub Date : 2021-01-14 Wei Sang; Yan-Yan Gong; Hua Cheng; Rui Zhang; Ye Yuan; Guang-Gao Fan; Zhi-Qin Wang; Cheng Chen; Francis Verpoort
Herein, a base‐controlled protocol was developed for the C‐N coupling of primary amines and 2‐chlorobenzimidazoles, affording a handful of secondary or tertiary amines in a selective fashion. Moreover, this protocol was realized under transition‐metal‐free conditions, and the variation of the base from iPr2NH to LiOtBu completely switched the selectivity from monoarylation to diarylation. Further investigations
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Uncatalyzed Formation of Polyaminoboranes from Diisopropylaminoborane and Primary Amines: a Kinetically Controlled Polymerization Reaction Adv. Synth. Catal. (IF 5.851) Pub Date : 2020-12-21 Marc Devillard; Carlos Antonio De Albuquerque Pinheiro; Elsa Caytan; Claire Roiland; Chiara Dinoi; Iker Del Rosal; Gilles Alcaraz
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Multicomponent and One‐pot Syntheses of Quinoxalines Adv. Synth. Catal. (IF 5.851) Pub Date : 2020-12-31 Lukas Biesen; Thomas J. J. Müller
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Selectivity in the Elaboration of Bicyclic Borazarenes Adv. Synth. Catal. (IF 5.851) Pub Date : 2020-12-23 Ayan Bhattacharjee; Geraint H. M. Davies; Borna Saeednia; Steven R. Wisniewski; Gary A. Molander
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Zwitterion‐Initiated Hydroboration of Alkynes and Styrene Adv. Synth. Catal. (IF 5.851) Pub Date : 2020-12-20 Alessandro Bismuto; Michael J. Cowley; Stephen P. Thomas
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Organocatalytic Deuteration Induced by the Dynamic Covalent Interaction of Imidazolium Cations with Ketones Adv. Synth. Catal. (IF 5.851) Pub Date : 2020-12-22 Konstantin I. Galkin; Evgeniy G. Gordeev; Valentine P. Ananikov
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