当前期刊: Nature Communications Go to current issue    加入关注   
显示样式:        排序: IF: - GO 导出
我的关注
我的收藏
您暂时未登录!
登录
  • Semiconductor photocatalysis to engineering deuterated N -alkyl pharmaceuticals enabled by synergistic activation of water and alkanols
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-18
    Zhaofei Zhang; Chuntian Qiu; Yangsen Xu; Qing Han; Junwang Tang; Kian Ping Loh; Chenliang Su

    Precisely controlled deuterium labeling at specific sites of N-alkyl drugs is crucial in drug-development as over 50% of the top-selling drugs contain N-alkyl groups, in which it is very challenging to selectively replace protons with deuterium atoms. With the goal of achieving controllable isotope-labeling in N-alkylated amines, we herein rationally design photocatalytic water-splitting to furnish

    更新日期:2020-09-20
  • Controlling in-gap end states by linking nonmagnetic atoms and artificially-constructed spin chains on superconductors
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-18
    Lucas Schneider; Sascha Brinker; Manuel Steinbrecher; Jan Hermenau; Thore Posske; Manuel dos Santos Dias; Samir Lounis; Roland Wiesendanger; Jens Wiebe

    Chains of magnetic atoms with either strong spin-orbit coupling or spiral magnetic order which are proximity-coupled to superconducting substrates can host topologically non-trivial Majorana bound states. The experimental signature of these states consists of spectral weight at the Fermi energy which is spatially localized near the ends of the chain. However, topologically trivial Yu-Shiba-Rusinov

    更新日期:2020-09-20
  • Electron hydrodynamics in anisotropic materials
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-18
    Georgios Varnavides; Adam S. Jermyn; Polina Anikeeva; Claudia Felser; Prineha Narang

    Rotational invariance strongly constrains the viscosity tensor of classical fluids. When this symmetry is broken in anisotropic materials a wide array of novel phenomena become possible. We explore electron fluid behaviors arising from the most general viscosity tensors in two and three dimensions, constrained only thermodynamics and crystal symmetries. We find nontrivial behaviors in both two- and

    更新日期:2020-09-20
  • Hot electrons in a nanowire hard X-ray detector
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-18
    Maximilian Zapf; Maurizio Ritzer; Lisa Liborius; Andreas Johannes; Martin Hafermann; Sven Schönherr; Jaime Segura-Ruiz; Gema Martínez-Criado; Werner Prost; Carsten Ronning

    Nanowire chip-based electrical and optical devices such as biochemical sensors, physical detectors, or light emitters combine outstanding functionality with a small footprint, reducing expensive material and energy consumption. The core functionality of many nanowire-based devices is embedded in their p-n junctions. To fully unleash their potential, such nanowire-based devices require – besides a high

    更新日期:2020-09-20
  • Three-dimensional strain dynamics govern the hysteresis in heterogeneous catalysis
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-18
    Aline R. Passos; Amélie Rochet; Luiza M. Manente; Ana F. Suzana; Ross Harder; Wonsuk Cha; Florian Meneau

    Understanding catalysts strain dynamic behaviours is crucial for the development of cost-effective, efficient, stable and long-lasting catalysts. Here, we reveal in situ three-dimensional strain evolution of single gold nanocrystals during a catalytic CO oxidation reaction under operando conditions with coherent X-ray diffractive imaging. We report direct observation of anisotropic strain dynamics

    更新日期:2020-09-20
  • Ultrasensitive and visual detection of SARS-CoV-2 using all-in-one dual CRISPR-Cas12a assay
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-18
    Xiong Ding; Kun Yin; Ziyue Li; Rajesh V. Lalla; Enrique Ballesteros; Maroun M. Sfeir; Changchun Liu

    The recent outbreak of novel coronavirus (SARS-CoV-2) causing COVID-19 disease spreads rapidly in the world. Rapid and early detection of SARS-CoV-2 facilitates early intervention and prevents the disease spread. Here, we present an All-In-One Dual CRISPR-Cas12a (AIOD-CRISPR) assay for one-pot, ultrasensitive, and visual SARS-CoV-2 detection. By targeting SARS-CoV-2’s nucleoprotein gene, two CRISPR

    更新日期:2020-09-20
  • Retrieving functional pathways of biomolecules from single-particle snapshots
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-18
    Ali Dashti; Ghoncheh Mashayekhi; Mrinal Shekhar; Danya Ben Hail; Salah Salah; Peter Schwander; Amedee des Georges; Abhishek Singharoy; Joachim Frank; Abbas Ourmazd

    A primary reason for the intense interest in structural biology is the fact that knowledge of structure can elucidate macromolecular functions in living organisms. Sustained effort has resulted in an impressive arsenal of tools for determining the static structures. But under physiological conditions, macromolecules undergo continuous conformational changes, a subset of which are functionally important

    更新日期:2020-09-20
  • Realization of acoustic spin transport in metasurface waveguides
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-18
    Yang Long; Danmei Zhang; Chenwen Yang; Jianmin Ge; Hong Chen; Jie Ren

    Spin angular momentum enables fundamental insights for topological matters, and practical implications for information devices. Exploiting the spin of carriers and waves is critical to achieving more controllable degrees of freedom and robust transport processes. Yet, due to the curl-free nature of longitudinal waves distinct from transverse electromagnetic waves, spin angular momenta of acoustic waves

    更新日期:2020-09-20
  • DsbA-L mediated renal tubulointerstitial fibrosis in UUO mice
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-18
    Xiaozhou Li; Jian Pan; Huiling Li; Guangdi Li; Xiangfeng Liu; Bohao Liu; Zhibiao He; Zhengyu Peng; Hongliang Zhang; Yijian Li; Xudong Xiang; Xiangping Chai; Yunchang Yuan; Peilin Zheng; Feng Liu; Dongshan Zhang

    Recent studies have reported that upregulation of disulfide-bond A oxidoreductase-like protein (DsbA-L) prevented lipid-induced renal injury in diabetic nephropathy (DN). However, the role and regulation of proximal tubular DsbA-L for renal tubulointerstitial fibrosis (TIF) remains unclear. In current study, we found that a proximal tubules-specific DsbA-L knockout mouse (PT-DsbA-L-KO) attenuated UUO-induced

    更新日期:2020-09-20
  • Ultralight covalent organic framework/graphene aerogels with hierarchical porosity
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-18
    Changxia Li; Jin Yang; Pradip Pachfule; Shuang Li; Meng-Yang Ye; Johannes Schmidt; Arne Thomas

    The fabrication of macroscopic objects from covalent organic frameworks (COFs) is challenging but of great significance to fully exploit their chemical functionality and porosity. Herein, COF/reduced graphene oxide (rGO) aerogels synthesized by a hydrothermal approach are presented. The COFs grow in situ along the surface of the 2D graphene sheets, which are stacked in a 3D fashion, forming an ultralight

    更新日期:2020-09-20
  • DR3 stimulation of adipose resident ILC2s ameliorates type 2 diabetes mellitus
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-18
    Pedram Shafiei-Jahani; Benjamin P. Hurrell; Lauriane Galle-Treger; Doumet Georges Helou; Emily Howard; Jacob Painter; Richard Lo; Gavin Lewis; Pejman Soroosh; Omid Akbari

    Disturbances in glucose homeostasis and low-grade chronic inflammation culminate into metabolic syndrome that increase the risk for the development of type 2 diabetes mellitus (T2DM). The recently discovered group 2 innate lymphoid cells (ILC2s) are capable of secreting copious amounts of type 2 cytokines to modulate metabolic homeostasis in adipose tissue. In this study, we have established that expression

    更新日期:2020-09-20
  • Meron-like topological spin defects in monolayer CrCl 3
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-18
    Xiaobo Lu; Ruixiang Fei; Linghan Zhu; Li Yang

    Noncollinear spin textures in low-dimensional magnetic systems have been studied for decades because of their extraordinary properties and promising applications derived from the chirality and topological nature. However, material realizations of topological spin states are still limited. Employing first-principles and Monte Carlo simulations, we propose that monolayer chromium trichloride (CrCl3)

    更新日期:2020-09-20
  • Event-related functional MRI of awake behaving pigeons at 7T
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-18
    Mehdi Behroozi; Xavier Helluy; Felix Ströckens; Meng Gao; Roland Pusch; Sepideh Tabrik; Martin Tegenthoff; Tobias Otto; Nikolai Axmacher; Robert Kumsta; Dirk Moser; Erhan Genc; Onur Güntürkün

    Animal-fMRI is a powerful method to understand neural mechanisms of cognition, but it remains a major challenge to scan actively participating small animals under low-stress conditions. Here, we present an event-related functional MRI platform in awake pigeons using single-shot RARE fMRI to investigate the neural fundaments for visually-guided decision making. We established a head-fixated Go/NoGo

    更新日期:2020-09-20
  • Graphene transistors for real-time monitoring molecular self-assembly dynamics
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-18
    Marco Gobbi; Agostino Galanti; Marc-Antoine Stoeckel; Bjorn Zyska; Sara Bonacchi; Stefan Hecht; Paolo Samorì

    Mastering the dynamics of molecular assembly on surfaces enables the engineering of predictable structural motifs to bestow programmable properties upon target substrates. Yet, monitoring self-assembly in real time on technologically relevant interfaces between a substrate and a solution is challenging, due to experimental complexity of disentangling interfacial from bulk phenomena. Here, we show that

    更新日期:2020-09-20
  • Integration of absolute multi-omics reveals dynamic protein-to-RNA ratios and metabolic interplay within mixed-domain microbiomes
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-18
    F. Delogu; B. J. Kunath; P. N. Evans; M. Ø. Arntzen; T. R. Hvidsten; P. B. Pope

    While the field of microbiology has adapted to the study of complex microbiomes via modern meta-omics techniques, we have not updated our basic knowledge regarding the quantitative levels of DNA, RNA and protein molecules within a microbial cell, which ultimately control cellular function. Here we report the temporal measurements of absolute RNA and protein levels per gene within a mixed bacterial-archaeal

    更新日期:2020-09-20
  • Vertical organic permeable dual-base transistors for logic circuits
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-18
    Erjuan Guo; Zhongbin Wu; Ghader Darbandy; Shen Xing; Shu-Jen Wang; Alexander Tahn; Michael Göbel; Alexander Kloes; Karl Leo; Hans Kleemann

    The main advantage of organic transistors with dual gates/bases is that the threshold voltages can be set as a function of the applied second gate/base bias, which is crucial for the application in logic gates and integrated circuits. However, incorporating a dual gate/base structure into an ultra-short channel vertical architecture represents a substantial challenge. Here, we realize a device concept

    更新日期:2020-09-20
  • Preferred crystallographic orientation of cellulose in plant primary cell walls
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-18
    Dan Ye; Sintu Rongpipi; Sarah N. Kiemle; William J. Barnes; Arielle M. Chaves; Chenhui Zhu; Victoria A. Norman; Alexander Liebman-Peláez; Alexander Hexemer; Michael F. Toney; Alison W. Roberts; Charles T. Anderson; Daniel J. Cosgrove; Esther W. Gomez; Enrique D. Gomez

    Cellulose, the most abundant biopolymer on earth, is a versatile, energy rich material found in the cell walls of plants, bacteria, algae, and tunicates. It is well established that cellulose is crystalline, although the orientational order of cellulose crystallites normal to the plane of the cell wall has not been characterized. A preferred orientational alignment of cellulose crystals could be an

    更新日期:2020-09-20
  • The influence of soil age on ecosystem structure and function across biomes
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-18
    Manuel Delgado-Baquerizo; Peter B. Reich; Richard D. Bardgett; David J. Eldridge; Hans Lambers; David A. Wardle; Sasha C. Reed; César Plaza; G. Kenny Png; Sigrid Neuhauser; Asmeret Asefaw Berhe; Stephen C. Hart; Hang-Wei Hu; Ji-Zheng He; Felipe Bastida; Sebastián Abades; Fernando D. Alfaro; Nick A. Cutler; Antonio Gallardo; Laura García-Velázquez; Patrick E. Hayes; Zeng-Yei Hseu; Cecilia A. Pérez;

    The importance of soil age as an ecosystem driver across biomes remains largely unresolved. By combining a cross-biome global field survey, including data for 32 soil, plant, and microbial properties in 16 soil chronosequences, with a global meta-analysis, we show that soil age is a significant ecosystem driver, but only accounts for a relatively small proportion of the cross-biome variation in multiple

    更新日期:2020-09-20
  • Multiplex flow magnetic tweezers reveal rare enzymatic events with single molecule precision
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-18
    Rohit Agarwal; Karl E. Duderstadt

    The application of forces and torques on the single molecule level has transformed our understanding of the dynamic properties of biomolecules, but rare intermediates have remained difficult to characterize due to limited throughput. Here, we describe a method that provides a 100-fold improvement in the throughput of force spectroscopy measurements with topological control, which enables routine imaging

    更新日期:2020-09-20
  • Cold spells in the Nordic Seas during the early Eocene Greenhouse
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-18
    Madeleine L. Vickers; Sabine K. Lengger; Stefano M. Bernasconi; Nicolas Thibault; Bo Pagh Schultz; Alvaro Fernandez; Clemens V. Ullmann; Paul McCormack; Christian J. Bjerrum; Jan Audun Rasmussen; Iben Winther Hougård; Christoph Korte

    The early Eocene (c. 56 - 48 million years ago) experienced some of the highest global temperatures in Earth’s history since the Mesozoic, with no polar ice. Reports of contradictory ice-rafted erratics and cold water glendonites in the higher latitudes have been largely dismissed due to ambiguity of the significance of these purported cold-climate indicators. Here we apply clumped isotope paleothermometry

    更新日期:2020-09-20
  • Global temperature modes shed light on the Holocene temperature conundrum
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-18
    Jürgen Bader; Johann Jungclaus; Natalie Krivova; Stephan Lorenz; Amanda Maycock; Thomas Raddatz; Hauke Schmidt; Matthew Toohey; Chi-Ju Wu; Martin Claussen

    Reconstructions of the global mean annual temperature evolution during the Holocene yield conflicting results. One temperature reconstruction shows global cooling during the late Holocene. The other reconstruction reveals global warming. Here we show that both a global warming mode and a cooling mode emerge when performing a spatio-temporal analysis of annual temperature variability during the Holocene

    更新日期:2020-09-20
  • A quantitative framework reveals ecological drivers of grassland microbial community assembly in response to warming
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-18
    Daliang Ning; Mengting Yuan; Linwei Wu; Ya Zhang; Xue Guo; Xishu Zhou; Yunfeng Yang; Adam P. Arkin; Mary K. Firestone; Jizhong Zhou

    Unraveling the drivers controlling community assembly is a central issue in ecology. Although it is generally accepted that selection, dispersal, diversification and drift are major community assembly processes, defining their relative importance is very challenging. Here, we present a framework to quantitatively infer community assembly mechanisms by phylogenetic bin-based null model analysis (iCAMP)

    更新日期:2020-09-20
  • Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-18
    Behnam Nabet; Fleur M. Ferguson; Bo Kyung A. Seong; Miljan Kuljanin; Alan L. Leggett; Mikaela L. Mohardt; Amanda Robichaud; Amy S. Conway; Dennis L. Buckley; Joseph D. Mancias; James E. Bradner; Kimberly Stegmaier; Nathanael S. Gray

    Chemical biology strategies for directly perturbing protein homeostasis including the degradation tag (dTAG) system provide temporal advantages over genetic approaches and improved selectivity over small molecule inhibitors. We describe dTAGV-1, an exclusively selective VHL-recruiting dTAG molecule, to rapidly degrade FKBP12F36V-tagged proteins. dTAGV-1 overcomes a limitation of previously reported

    更新日期:2020-09-20
  • An integrated personal and population-based Egyptian genome reference
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-18
    Inken Wohlers; Axel Künstner; Matthias Munz; Michael Olbrich; Anke Fähnrich; Verónica Calonga-Solís; Caixia Ma; Misa Hirose; Shaaban El-Mosallamy; Mohamed Salama; Hauke Busch; Saleh Ibrahim

    A small number of de novo assembled human genomes have been reported to date, and few have been complemented with population-based genetic variation, which is particularly important for North Africa, a region underrepresented in current genome-wide references. Here, we combine long- and short-read whole-genome sequencing data with recent assembly approaches into a de novo assembly of an Egyptian genome

    更新日期:2020-09-20
  • Association of APOE e2 genotype with Alzheimer’s and non-Alzheimer’s neurodegenerative pathologies
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-18
    Terry E. Goldberg; Edward D. Huey; D. P. Devanand

    The apolipoprotein E (APOE) gene contains both the major common risk variant for late onset Alzheimer’s disease (AD), e4, and the major neuroprotective variant, e2. Here we examine the association of APOE e2 with multiple neurodegenerative pathologies, leveraging the NACC v. 10 database of 1557 brains that included 130 e2 carriers and 679 e4 carriers in order to examine potential neuroprotective effects

    更新日期:2020-09-20
  • SPT6-driven error-free DNA repair safeguards genomic stability of glioblastoma cancer stem-like cells
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-18
    Elisabeth Anne Adanma Obara; Diana Aguilar-Morante; Rikke Darling Rasmussen; Alex Frias; Kristoffer Vitting-Serup; Yi Chieh Lim; Kirstine Juul Elbæk; Henriette Pedersen; Lina Vardouli; Kamilla Ellermann Jensen; Jane Skjoth-Rasmussen; Jannick Brennum; Lucie Tuckova; Robert Strauss; Christoffel Dinant; Jiri Bartek; Petra Hamerlik

    Glioblastoma cancer-stem like cells (GSCs) display marked resistance to ionizing radiation (IR), a standard of care for glioblastoma patients. Mechanisms underpinning radio-resistance of GSCs remain largely unknown. Chromatin state and the accessibility of DNA lesions to DNA repair machineries are crucial for the maintenance of genomic stability. Understanding the functional impact of chromatin remodeling

    更新日期:2020-09-20
  • Structural and mechanistic basis of capsule O -acetylation in Neisseria meningitidis serogroup A
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-18
    Timm Fiebig; Johannes T. Cramer; Andrea Bethe; Petra Baruch; Ute Curth; Jana I. Führing; Falk F. R. Buettner; Ulrich Vogel; Mario Schubert; Roman Fedorov; Martina Mühlenhoff

    O-Acetylation of the capsular polysaccharide (CPS) of Neisseria meningitidis serogroup A (NmA) is critical for the induction of functional immune responses, making this modification mandatory for CPS-based anti-NmA vaccines. Using comprehensive NMR studies, we demonstrate that O-acetylation stabilizes the labile anomeric phosphodiester-linkages of the NmA-CPS and occurs in position C3 and C4 of the

    更新日期:2020-09-20
  • Author Correction: A role for Biofoundries in rapid development and validation of automated SARS-CoV-2 clinical diagnostics
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-17
    Michael A. Crone; Miles Priestman; Marta Ciechonska; Kirsten Jensen; David J. Sharp; Arthi Anand; Paul Randell; Marko Storch; Paul S. Freemont

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

    更新日期:2020-09-18
  • Publisher Correction: Immunoprophylactic and immunotherapeutic control of hormone receptor-positive breast cancer
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-17
    Aitziber Buqué; Norma Bloy; Maria Perez-Lanzón; Kristina Iribarren; Juliette Humeau; Jonathan G. Pol; Sarah Levesque; Laura Mondragon; Takahiro Yamazaki; Ai Sato; Fernando Aranda; Sylvère Durand; Alexandre Boissonnas; Jitka Fucikova; Laura Senovilla; David Enot; Michal Hensler; Margerie Kremer; Gautier Stoll; Yang Hu; Chiara Massa; Silvia C. Formenti; Barbara Seliger; Olivier Elemento; Radek Spisek;

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

    更新日期:2020-09-18
  • Chemical engineering of quasicrystal approximants in lanthanide-based coordination solids
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-17
    Laura Voigt; Mariusz Kubus; Kasper S. Pedersen

    Tessellation of self-assembling molecular building blocks is a promising strategy to design metal-organic materials exhibiting geometrical frustration and ensuing frustrated physical properties. Appearing in two-dimensional quasiperiodic phases, tilings consisting of five-vertex nodes are regarded as approximants for quasicrystals. Unfortunately, these structural motifs are exceedingly rare due to

    更新日期:2020-09-18
  • Using synchronized oscillators to compute the maximum independent set
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-17
    Antik Mallick; Mohammad Khairul Bashar; Daniel S. Truesdell; Benton H. Calhoun; Siddharth Joshi; Nikhil Shukla

    Not all computing problems are created equal. The inherent complexity of processing certain classes of problems using digital computers has inspired the exploration of alternate computing paradigms. Coupled oscillators exhibiting rich spatio-temporal dynamics have been proposed for solving hard optimization problems. However, the physical implementation of such systems has been constrained to small

    更新日期:2020-09-18
  • mTOR-mediated cancer drug resistance suppresses autophagy and generates a druggable metabolic vulnerability
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-17
    Niklas Gremke; Pierfrancesco Polo; Aaron Dort; Jean Schneikert; Sabrina Elmshäuser; Corinna Brehm; Ursula Klingmüller; Anna Schmitt; Hans Christian Reinhardt; Oleg Timofeev; Michael Wanzel; Thorsten Stiewe

    Cancer cells have a characteristic metabolism, mostly caused by alterations in signal transduction networks rather than mutations in metabolic enzymes. For metabolic drugs to be cancer-selective, signaling alterations need to be identified that confer a druggable vulnerability. Here, we demonstrate that many tumor cells with an acquired cancer drug resistance exhibit increased sensitivity to mechanistically

    更新日期:2020-09-18
  • Porous cage-derived nanomaterial inks for direct and internal three-dimensional printing
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-17
    Tangi Aubert; Jen-Yu Huang; Kai Ma; Tobias Hanrath; Ulrich Wiesner

    The convergence of 3D printing techniques and nanomaterials is generating a compelling opportunity space to create advanced materials with multiscale structural control and hierarchical functionalities. While most nanoparticles consist of a dense material, less attention has been payed to 3D printing of nanoparticles with intrinsic porosity. Here, we combine ultrasmall (about 10 nm) silica nanocages

    更新日期:2020-09-18
  • A systematic review of antibody mediated immunity to coronaviruses: kinetics, correlates of protection, and association with severity
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-17
    Angkana T. Huang; Bernardo Garcia-Carreras; Matt D. T. Hitchings; Bingyi Yang; Leah C. Katzelnick; Susan M. Rattigan; Brooke A. Borgert; Carlos A. Moreno; Benjamin D. Solomon; Luke Trimmer-Smith; Veronique Etienne; Isabel Rodriguez-Barraquer; Justin Lessler; Henrik Salje; Donald S. Burke; Amy Wesolowski; Derek A. T. Cummings

    Many public health responses and modeled scenarios for COVID-19 outbreaks caused by SARS-CoV-2 assume that infection results in an immune response that protects individuals from future infections or illness for some amount of time. The presence or absence of protective immunity due to infection or vaccination (when available) will affect future transmission and illness severity. Here, we review the

    更新日期:2020-09-18
  • Eukaryotic cell biology is temporally coordinated to support the energetic demands of protein homeostasis
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-17
    John S. O’ Neill; Nathaniel P. Hoyle; J. Brian Robertson; Rachel S. Edgar; Andrew D. Beale; Sew Y. Peak-Chew; Jason Day; Ana S. H. Costa; Christian Frezza; Helen C. Causton

    Yeast physiology is temporally regulated, this becomes apparent under nutrient-limited conditions and results in respiratory oscillations (YROs). YROs share features with circadian rhythms and interact with, but are independent of, the cell division cycle. Here, we show that YROs minimise energy expenditure by restricting protein synthesis until sufficient resources are stored, while maintaining osmotic

    更新日期:2020-09-18
  • Carbon pricing and planetary boundaries
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-17
    Gustav Engström; Johan Gars; Chandra Krishnamurthy; Daniel Spiro; Raphael Calel; Therese Lindahl; Badri Narayanan

    Human activities are threatening to push the Earth system beyond its planetary boundaries, risking catastrophic and irreversible global environmental change. Action is urgently needed, yet well-intentioned policies designed to reduce pressure on a single boundary can lead, through economic linkages, to aggravation of other pressures. In particular, the potential policy spillovers from an increase in

    更新日期:2020-09-18
  • Ring-opening polymerization-induced crystallization-driven self-assembly of poly-L-lactide- block -polyethylene glycol block copolymers (ROPI-CDSA)
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-17
    Paul J. Hurst; Alexander M. Rakowski; Joseph P. Patterson

    The self-assembly of block copolymers into 1D, 2D and 3D nano- and microstructures is of great interest for a wide range of applications. A key challenge in this field is obtaining independent control over molecular structure and hierarchical structure in all dimensions using scalable one-pot chemistry. Here we report on the ring opening polymerization-induced crystallization-driven self-assembly (ROPI-CDSA)

    更新日期:2020-09-18
  • In vivo localization of chronically implanted electrodes and optic fibers in mice
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-17
    Bálint Király; Diána Balázsfi; Ildikó Horváth; Nicola Solari; Katalin Sviatkó; Katalin Lengyel; Eszter Birtalan; Magor Babos; Gergő Bagaméry; Domokos Máthé; Krisztián Szigeti; Balázs Hangya

    Electrophysiology provides a direct readout of neuronal activity at a temporal precision only limited by the sampling rate. However, interrogating deep brain structures, implanting multiple targets or aiming at unusual angles still poses significant challenges for operators, and errors are only discovered by post-hoc histological reconstruction. Here, we propose a method combining the high-resolution

    更新日期:2020-09-18
  • Chromatin remodeling in bovine embryos indicates species-specific regulation of genome activation
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-17
    Michelle M. Halstead; Xin Ma; Chuan Zhou; Richard M. Schultz; Pablo J. Ross

    The shift from maternal to embryonic control is a critical developmental milestone in preimplantation development. Widespread transcriptomic and epigenetic remodeling facilitate this transition from terminally differentiated gametes to totipotent blastomeres, but the identity of transcription factors (TF) and genomic elements regulating embryonic genome activation (EGA) are poorly defined. The timing

    更新日期:2020-09-18
  • The lysophospholipase D enzyme Gdpd3 is required to maintain chronic myelogenous leukaemia stem cells
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-17
    Kazuhito Naka; Ryosuke Ochiai; Eriko Matsubara; Chie Kondo; Kyung-Min Yang; Takayuki Hoshii; Masatake Araki; Kimi Araki; Yusuke Sotomaru; Ko Sasaki; Kinuko Mitani; Dong-Wook Kim; Akira Ooshima; Seong-Jin Kim

    Although advanced lipidomics technology facilitates quantitation of intracellular lipid components, little is known about the regulation of lipid metabolism in cancer cells. Here, we show that disruption of the Gdpd3 gene encoding a lysophospholipase D enzyme significantly decreased self-renewal capacity in murine chronic myelogenous leukaemia (CML) stem cells in vivo. Sophisticated lipidomics analyses

    更新日期:2020-09-18
  • Evaluating the informativeness of deep learning annotations for human complex diseases
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-17
    Kushal K. Dey; Bryce van de Geijn; Samuel Sungil Kim; Farhad Hormozdiari; David R. Kelley; Alkes L. Price

    Deep learning models have shown great promise in predicting regulatory effects from DNA sequence, but their informativeness for human complex diseases is not fully understood. Here, we evaluate genome-wide SNP annotations from two previous deep learning models, DeepSEA and Basenji, by applying stratified LD score regression to 41 diseases and traits (average N = 320K), conditioning on a broad set of

    更新日期:2020-09-18
  • Rapid incorporation of Favipiravir by the fast and permissive viral RNA polymerase complex results in SARS-CoV-2 lethal mutagenesis
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-17
    Ashleigh Shannon; Barbara Selisko; Nhung-Thi-Tuyet Le; Johanna Huchting; Franck Touret; Géraldine Piorkowski; Véronique Fattorini; François Ferron; Etienne Decroly; Chris Meier; Bruno Coutard; Olve Peersen; Bruno Canard

    The ongoing Corona Virus Disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has emphasized the urgent need for antiviral therapeutics. The viral RNA-dependent-RNA-polymerase (RdRp) is a promising target with polymerase inhibitors successfully used for the treatment of several viral diseases. We demonstrate here that Favipiravir predominantly exerts

    更新日期:2020-09-18
  • Extracellular bacterial lymphatic metastasis drives Streptococcus pyogenes systemic infection
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-17
    Matthew K. Siggins; Nicola N. Lynskey; Lucy E. Lamb; Louise A. Johnson; Kristin K. Huse; Max Pearson; Suneale Banerji; Claire E. Turner; Kevin Woollard; David G. Jackson; Shiranee Sriskandan

    Unassisted metastasis through the lymphatic system is a mechanism of dissemination thus far ascribed only to cancer cells. Here, we report that Streptococcus pyogenes also hijack lymphatic vessels to escape a local infection site, transiting through sequential lymph nodes and efferent lymphatic vessels to enter the bloodstream. Contrasting with previously reported mechanisms of intracellular pathogen

    更新日期:2020-09-18
  • SARS-CoV-2 seroprevalence and neutralizing activity in donor and patient blood
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-17
    Dianna L. Ng; Gregory M. Goldgof; Brian R. Shy; Andrew G. Levine; Joanna Balcerek; Sagar P. Bapat; John Prostko; Mary Rodgers; Kelly Coller; Sandra Pearce; Sergej Franz; Li Du; Mars Stone; Satish K. Pillai; Alicia Sotomayor-Gonzalez; Venice Servellita; Claudia Sanchez San Martin; Andrea Granados; Dustin R. Glasner; Lucy M. Han; Kent Truong; Naomi Akagi; David N. Nguyen; Neil M. Neumann; Daniel Qazi;

    Given the limited availability of serological testing to date, the seroprevalence of SARS-CoV-2-specific antibodies in different populations has remained unclear. Here, we report very low SARS-CoV-2 seroprevalence in two San Francisco Bay Area populations. Seroreactivity was 0.26% in 387 hospitalized patients admitted for non-respiratory indications and 0.1% in 1,000 blood donors in early April 2020

    更新日期:2020-09-18
  • Fully organic compliant dry electrodes self-adhesive to skin for long-term motion-robust epidermal biopotential monitoring
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-17
    Lei Zhang; Kirthika Senthil Kumar; Hao He; Catherine Jiayi Cai; Xu He; Huxin Gao; Shizhong Yue; Changsheng Li; Raymond Chee-Seong Seet; Hongliang Ren; Jianyong Ouyang

    Wearable dry electrodes are needed for long-term biopotential recordings but are limited by their imperfect compliance with the skin, especially during body movements and sweat secretions, resulting in high interfacial impedance and motion artifacts. Herein, we report an intrinsically conductive polymer dry electrode with excellent self-adhesiveness, stretchability, and conductivity. It shows much

    更新日期:2020-09-18
  • Pressure-stabilized divalent ozonide CaO 3 and its impact on Earth’s oxygen cycles
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-17
    Yanchao Wang; Meiling Xu; Liuxiang Yang; Bingmin Yan; Qin Qin; Xuecheng Shao; Yunwei Zhang; Dajian Huang; Xiaohuan Lin; Jian Lv; Dongzhou Zhang; Huiyang Gou; Ho-kwang Mao; Changfeng Chen; Yanming Ma

    High pressure can drastically alter chemical bonding and produce exotic compounds that defy conventional wisdom. Especially significant are compounds pertaining to oxygen cycles inside Earth, which hold key to understanding major geological events that impact the environment essential to life on Earth. Here we report the discovery of pressure-stabilized divalent ozonide CaO3 crystal that exhibits intriguing

    更新日期:2020-09-18
  • Wood hemicelluloses exert distinct biomechanical contributions to cellulose fibrillar networks
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-17
    Jennie Berglund; Deirdre Mikkelsen; Bernadine M. Flanagan; Sushil Dhital; Stefan Gaunitz; Gunnar Henriksson; Mikael E. Lindström; Gleb E. Yakubov; Michael J. Gidley; Francisco Vilaplana

    Hemicelluloses, a family of heterogeneous polysaccharides with complex molecular structures, constitute a fundamental component of lignocellulosic biomass. However, the contribution of each hemicellulose type to the mechanical properties of secondary plant cell walls remains elusive. Here we homogeneously incorporate different combinations of extracted and purified hemicelluloses (xylans and glucomannans)

    更新日期:2020-09-18
  • Reinforcing materials modelling by encoding the structures of defects in crystalline solids into distortion scores
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-17
    Alexandra M. Goryaeva; Clovis Lapointe; Chendi Dai; Julien Dérès; Jean-Bernard Maillet; Mihai-Cosmin Marinica

    This work revises the concept of defects in crystalline solids and proposes a universal strategy for their characterization at the atomic scale using outlier detection based on statistical distances. The proposed strategy provides a generic measure that describes the distortion score of local atomic environments. This score facilitates automatic defect localization and enables a stratified description

    更新日期:2020-09-18
  • Continuous 3D printing from one single droplet
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-17
    Yu Zhang; Zhichao Dong; Chuxin Li; Huifeng Du; Nicholas X. Fang; Lei Wu; Yanlin Song

    3D printing has become one of the most promising methods to construct delicate 3D structures. However, precision and material utilization efficiency are limited. Here, we propose a one-droplet 3D printing strategy to fabricate controllable 3D structures from a single droplet ascribing to the receding property of the three-phase contact line (TCL) of the resin droplet. The well-controlled dewetting

    更新日期:2020-09-18
  • Multiple capsid protein binding sites mediate selective packaging of the alphavirus genomic RNA
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-17
    Rebecca S. Brown; Dimitrios G. Anastasakis; Markus Hafner; Margaret Kielian

    The alphavirus capsid protein (Cp) selectively packages genomic RNA (gRNA) into the viral nucleocapsid to produce infectious virus. Using photoactivatable ribonucleoside crosslinking and an innovative biotinylated Cp retrieval method, here we comprehensively define binding sites for Semliki Forest virus (SFV) Cp on the gRNA. While data in infected cells demonstrate Cp binding to the proposed genome

    更新日期:2020-09-18
  • Organic-to-inorganic structural chirality transfer in a 2D hybrid perovskite and impact on Rashba-Dresselhaus spin-orbit coupling
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-17
    Manoj K. Jana; Ruyi Song; Haoliang Liu; Dipak Raj Khanal; Svenja M. Janke; Rundong Zhao; Chi Liu; Z. Valy Vardeny; Volker Blum; David B. Mitzi

    Translation of chirality and asymmetry across structural motifs and length scales plays a fundamental role in nature, enabling unique functionalities in contexts ranging from biological systems to synthetic materials. Here, we introduce a structural chirality transfer across the organic–inorganic interface in two-dimensional hybrid perovskites using appropriate chiral organic cations. The preferred

    更新日期:2020-09-18
  • Direct growth of uniform carbon nitride layers with extended optical absorption towards efficient water-splitting photoanodes
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-17
    Jiani Qin; Jesús Barrio; Guiming Peng; Jonathan Tzadikov; Liel Abisdris; Michael Volokh; Menny Shalom

    A general synthesis of carbon nitride (CN) films with extended optical absorption, excellent charge separation under illumination, and outstanding performance as a photoanode in water-splitting photoelectrochemical cells is reported. To this end, we introduced a universal method to rapidly grow CN monomers directly from a hot saturated solution on various substrates. Upon calcination, a highly uniform

    更新日期:2020-09-18
  • Author Correction: Targeting QKI-7 in vivo restores endothelial cell function in diabetes
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-16
    Chunbo Yang; Magdalini Eleftheriadou; Sophia Kelaini; Thomas Morrison; Marta Vilà González; Rachel Caines; Nicola Edwards; Andrew Yacoub; Kevin Edgar; Arya Moez; Aleksandar Ivetic; Anna Zampetaki; Lingfang Zeng; Fiona L. Wilkinson; Noemi Lois; Alan W. Stitt; David J. Grieve; Andriana Margariti

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

    更新日期:2020-09-16
  • Author Correction: Giant room temperature anomalous Hall effect and tunable topology in a ferromagnetic topological semimetal Co 2 MnAl
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-16
    Peigang Li; Jahyun Koo; Wei Ning; Jinguo Li; Leixin Miao; Lujin Min; Yanglin Zhu; Yu Wang; Nasim Alem; Chao-Xing Liu; Zhiqiang Mao; Binghai Yan

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

    更新日期:2020-09-16
  • Publisher Correction: Improving the accuracy of medical diagnosis with causal machine learning
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-16
    Jonathan G. Richens; Ciarán M. Lee; Saurabh Johri

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

    更新日期:2020-09-16
  • Author Correction: Identification and characterization of Cardiac Glycosides as senolytic compounds
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-16
    Francisco Triana-Martínez; Pilar Picallos-Rabina; Sabela Da Silva-Álvarez; Federico Pietrocola; Susana Llanos; Verónica Rodilla; Enrica Soprano; Pablo Pedrosa; Alba Ferreirós; Marta Barradas; Fernanda Hernández-González; Marta Lalinde; Neus Prats; Cristina Bernadó; Patricia González; María Gómez; Maria P. Ikonomopoulou; Pablo J. Fernández-Marcos; Tomás García-Caballero; Pablo del Pino; Joaquín Arribas;

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

    更新日期:2020-09-16
  • Author Correction: Ancient genomes reveal social and genetic structure of Late Neolithic Switzerland
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-16
    Anja Furtwängler; A. B. Rohrlach; Thiseas C. Lamnidis; Luka Papac; Gunnar U. Neumann; Inga Siebke; Ella Reiter; Noah Steuri; Jürgen Hald; Anthony Denaire; Bernadette Schnitzler; Joachim Wahl; Marianne Ramstein; Verena J. Schuenemann; Philipp W. Stockhammer; Albert Hafner; Sandra Lösch; Wolfgang Haak; Stephan Schiffels; Johannes Krause

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

    更新日期:2020-09-16
  • Reductions in commuting mobility correlate with geographic differences in SARS-CoV-2 prevalence in New York City
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-16
    Stephen M. Kissler; Nishant Kishore; Malavika Prabhu; Dena Goffman; Yaakov Beilin; Ruth Landau; Cynthia Gyamfi-Bannerman; Brian T. Bateman; Jon Snyder; Armin S. Razavi; Daniel Katz; Jonathan Gal; Angela Bianco; Joanne Stone; Daniel Larremore; Caroline O. Buckee; Yonatan H. Grad

    SARS-CoV-2-related mortality and hospitalizations differ substantially between New York City neighborhoods. Mitigation efforts require knowing the extent to which these disparities reflect differences in prevalence and understanding the associated drivers. Here, we report the prevalence of SARS-CoV-2 in New York City boroughs inferred using tests administered to 1,746 pregnant women hospitalized for

    更新日期:2020-09-16
  • Phonon heat transport in cavity-mediated optomechanical nanoresonators
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-16
    Cheng Yang; Xinrui Wei; Jiteng Sheng; Haibin Wu

    The understanding of heat transport in nonequilibrium thermodynamics is an important research frontier, which is crucial for implementing novel thermodynamic devices, such as heat engines and refrigerators. The convection, conduction, and radiation are the well-known basic ways to transfer thermal energy. Here, we demonstrate a different mechanism of phonon heat transport between two spatially separated

    更新日期:2020-09-16
  • Potential impacts of mercury released from thawing permafrost
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-16
    Kevin Schaefer; Yasin Elshorbany; Elchin Jafarov; Paul F. Schuster; Robert G. Striegl; Kimberly P. Wickland; Elsie M. Sunderland

    Mercury (Hg) is a naturally occurring element that bonds with organic matter and, when converted to methylmercury, is a potent neurotoxicant. Here we estimate potential future releases of Hg from thawing permafrost for low and high greenhouse gas emissions scenarios using a mechanistic model. By 2200, the high emissions scenario shows annual permafrost Hg emissions to the atmosphere comparable to current

    更新日期:2020-09-16
Contents have been reproduced by permission of the publishers.
导出
全部期刊列表>>
《自然》编辑与您分享如何成为优质审稿人-信息流
物理学研究前沿热点精选期刊推荐
科研绘图
欢迎报名注册2020量子在线大会
化学领域亟待解决的问题
材料学研究精选新
GIANT
自然职场线上招聘会
ACS ES&T Engineering
ACS ES&T Water
屿渡论文,编辑服务
阿拉丁试剂right
张晓晨
田蕾蕾
李闯创
刘天飞
隐藏1h前已浏览文章
课题组网站
新版X-MOL期刊搜索和高级搜索功能介绍
ACS材料视界
天合科研
x-mol收录
X-MOL
清华大学
廖矿标
陈永胜
试剂库存
down
wechat
bug