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  • Publisher Correction: A stabilized glycomimetic conjugate vaccine inducing protective antibodies against Neisseria meningitidis serogroup A
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-25
    Jacopo Enotarpi; Marta Tontini; Cristiana Balocchi; Daan van der Es; Ludovic Auberger; Evita Balducci; Filippo Carboni; Daniela Proietti; Daniele Casini; Dmitri V. Filippov; Hermen S. Overkleeft; Gijsbert A. van der Marel; Cinzia Colombo; Maria Rosaria Romano; Francesco Berti; Paolo Costantino; Jeroen D. C. Codeé; Luigi Lay; Roberto Adamo

    A Correction to this paper has been published: https://doi.org/10.1038/s41467-020-20120-4

    更新日期:2020-11-26
  • Author Correction: Quantum clocks and the temporal localisability of events in the presence of gravitating quantum systems
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-25
    Esteban Castro-Ruiz; Flaminia Giacomini; Alessio Belenchia; Časlav Brukner

    A Correction to this paper has been published: https://doi.org/10.1038/s41467-020-20105-3

    更新日期:2020-11-26
  • Retraction Note: Air-stable superparamagnetic metal nanoparticles entrapped in graphene oxide matrix
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-25
    Jiří Tuček; Zdeněk Sofer; Daniel Bouša; Martin Pumera; Kateřina Holá; Aneta Malá; Kateřina Poláková; Markéta Havrdová; Klára Čépe; Ondřej Tomanec; Radek Zbořil

    This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1038/s41467-020-19968-3.

    更新日期:2020-11-26
  • Breaking boundaries in subduction science
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-25

    Subduction is the primary driver of plate tectonics, yet we still do not fully understand how subduction zones initiate or the budgets of life-supporting elements recycled via subduction. At Nature Communications, we advocate for more transdisciplinary initiatives and collaborative projects, which are essential if we are to continue to bring new dynamics to subduction research.

    更新日期:2020-11-26
  • High-resolution sampling of beam-driven plasma wakefields
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-25
    S. Schröder; C. A. Lindstrøm; S. Bohlen; G. Boyle; R. D’Arcy; S. Diederichs; M. J. Garland; P. Gonzalez; A. Knetsch; V. Libov; P. Niknejadi; K. Pøder; L. Schaper; B. Schmidt; B. Sheeran; G. Tauscher; S. Wesch; J. Zemella; M. Zeng; J. Osterhoff

    Plasma-wakefield accelerators driven by intense particle beams promise to significantly reduce the size of future high-energy facilities. Such applications require particle beams with a well-controlled energy spectrum, which necessitates detailed tailoring of the plasma wakefield. Precise measurements of the effective wakefield structure are therefore essential for optimising the acceleration process

    更新日期:2020-11-26
  • Intelligent non-colorimetric indicators for the perishable supply chain by non-wovens with photo-programmed thermal response
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-25
    Luigi Romano; Alberto Portone; Maria-Beatrice Coltelli; Francesco Patti; Rosalba Saija; Maria Antonia Iatì; Giuseppe Gallone; Andrea Lazzeri; Serena Danti; Onofrio M. Maragò; Andrea Camposeo; Dario Pisignano; Luana Persano

    Spoiled perishable products, such as food and drugs exposed to inappropriate temperature, cause million illnesses every year. Risks range from intoxication due to pathogen-contaminated edibles, to suboptimal potency of temperature-sensitive vaccines. High-performance and low-cost indicators are needed, based on conformable materials whose properties change continuously and irreversibly depending on

    更新日期:2020-11-26
  • Biased localization of actin binding proteins by actin filament conformation
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-25
    Andrew R. Harris; Pamela Jreij; Brian Belardi; Aaron M. Joffe; Andreas R. Bausch; Daniel A. Fletcher

    The assembly of actin filaments into distinct cytoskeletal structures plays a critical role in cell physiology, but how proteins localize differentially to these structures within a shared cytoplasm remains unclear. Here, we show that the actin-binding domains of accessory proteins can be sensitive to filament conformational changes. Using a combination of live cell imaging and in vitro single molecule

    更新日期:2020-11-26
  • Vibrational couplings and energy transfer pathways of water’s bending mode
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-25
    Chun-Chieh Yu; Kuo-Yang Chiang; Masanari Okuno; Takakazu Seki; Tatsuhiko Ohto; Xiaoqing Yu; Vitaly Korepanov; Hiro-o Hamaguchi; Mischa Bonn; Johannes Hunger; Yuki Nagata

    Coupling between vibrational modes is essential for energy transfer and dissipation in condensed matter. For water, different O-H stretch modes are known to be very strongly coupled both within and between water molecules, leading to ultrafast dissipation and delocalization of vibrational energy. In contrast, the information on the vibrational coupling of the H-O-H bending mode of water is lacking

    更新日期:2020-11-26
  • The genetic architecture of sporadic and multiple consecutive miscarriage
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-25
    Triin Laisk; Ana Luiza G. Soares; Teresa Ferreira; Jodie N. Painter; Jenny C. Censin; Samantha Laber; Jonas Bacelis; Chia-Yen Chen; Maarja Lepamets; Kuang Lin; Siyang Liu; Iona Y. Millwood; Avinash Ramu; Jennifer Southcombe; Marianne S. Andersen; Ling Yang; Christian M. Becker; Anders D. Børglum; Scott D. Gordon; Jonas Bybjerg-Grauholm; Øyvind Helgeland; David M. Hougaard; Xin Jin; Stefan Johansson;

    Miscarriage is a common, complex trait affecting ~15% of clinically confirmed pregnancies. Here we present the results of large-scale genetic association analyses with 69,054 cases from five different ancestries for sporadic miscarriage, 750 cases of European ancestry for multiple (≥3) consecutive miscarriage, and up to 359,469 female controls. We identify one genome-wide significant association (rs146350366

    更新日期:2020-11-26
  • No evidence for increased transmissibility from recurrent mutations in SARS-CoV-2
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-25
    Lucy van Dorp; Damien Richard; Cedric C. S. Tan; Liam P. Shaw; Mislav Acman; François Balloux

    COVID-19 is caused by the coronavirus SARS-CoV-2, which jumped into the human population in late 2019 from a currently uncharacterised animal reservoir. Due to this recent association with humans, SARS-CoV-2 may not yet be fully adapted to its human host. This has led to speculations that SARS-CoV-2 may be evolving towards higher transmissibility. The most plausible mutations under putative natural

    更新日期:2020-11-26
  • Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-25
    Valgerdur Steinthorsdottir; Ralph McGinnis; Nicholas O. Williams; Lilja Stefansdottir; Gudmar Thorleifsson; Scott Shooter; João Fadista; Jon K. Sigurdsson; Kirsi M. Auro; Galina Berezina; Maria-Carolina Borges; Suzannah Bumpstead; Jonas Bybjerg-Grauholm; Irina Colgiu; Vivien A. Dolby; Frank Dudbridge; Stephanie M. Engel; Christopher S. Franklin; Michael L. Frigge; Yr Frisbaek; Reynir T. Geirsson; Frank

    Preeclampsia is a serious complication of pregnancy, affecting both maternal and fetal health. In genome-wide association meta-analysis of European and Central Asian mothers, we identify sequence variants that associate with preeclampsia in the maternal genome at ZNF831/20q13 and FTO/16q12. These are previously established variants for blood pressure (BP) and the FTO variant has also been associated

    更新日期:2020-11-26
  • Stretchable, dynamic covalent polymers for soft, long-lived bioresorbable electronic stimulators designed to facilitate neuromuscular regeneration
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-25
    Yeon Sik Choi; Yuan-Yu Hsueh; Jahyun Koo; Quansan Yang; Raudel Avila; Buwei Hu; Zhaoqian Xie; Geumbee Lee; Zheng Ning; Claire Liu; Yameng Xu; Young Joong Lee; Weikang Zhao; Jun Fang; Yujun Deng; Seung Min Lee; Abraham Vázquez-Guardado; Iwona Stepien; Ying Yan; Joseph W. Song; Chad Haney; Yong Suk Oh; Wentai Liu; Hong-Joon Yun; Anthony Banks; Matthew R. MacEwan; Guillermo A. Ameer; Wilson Z. Ray; Yonggang

    Bioresorbable electronic stimulators are of rapidly growing interest as unusual therapeutic platforms, i.e., bioelectronic medicines, for treating disease states, accelerating wound healing processes and eliminating infections. Here, we present advanced materials that support operation in these systems over clinically relevant timeframes, ultimately bioresorbing harmlessly to benign products without

    更新日期:2020-11-26
  • Designed CXCR4 mimic acts as a soluble chemokine receptor that blocks atherogenic inflammation by agonist-specific targeting
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-25
    Christos Kontos; Omar El Bounkari; Christine Krammer; Dzmitry Sinitski; Kathleen Hille; Chunfang Zan; Guangyao Yan; Sijia Wang; Ying Gao; Markus Brandhofer; Remco T. A. Megens; Adrian Hoffmann; Jessica Pauli; Yaw Asare; Simona Gerra; Priscila Bourilhon; Lin Leng; Hans-Henning Eckstein; Wolfgang E. Kempf; Jaroslav Pelisek; Ozgun Gokce; Lars Maegdefessel; Richard Bucala; Martin Dichgans; Christian Weber;

    Targeting a specific chemokine/receptor axis in atherosclerosis remains challenging. Soluble receptor-based strategies are not established for chemokine receptors due to their discontinuous architecture. Macrophage migration-inhibitory factor (MIF) is an atypical chemokine that promotes atherosclerosis through CXC-motif chemokine receptor-4 (CXCR4). However, CXCR4/CXCL12 interactions also mediate atheroprotection

    更新日期:2020-11-26
  • The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-25
    Kaushik Bhattacharya; Lorenz Weidenauer; Tania Morán Luengo; Ellis C. Pieters; Pablo C. Echeverría; Lilia Bernasconi; Diana Wider; Yashar Sadian; Margreet B. Koopman; Matthieu Villemin; Christoph Bauer; Stefan G. D. Rüdiger; Manfredo Quadroni; Didier Picard

    Hop/Stip1/Sti1 is thought to be essential as a co-chaperone to facilitate substrate transfer between the Hsp70 and Hsp90 molecular chaperones. Despite this proposed key function for protein folding and maturation, it is not essential in a number of eukaryotes and bacteria lack an ortholog. We set out to identify and to characterize its eukaryote-specific function. Human cell lines and the budding yeast

    更新日期:2020-11-26
  • Photosynthetic hydrogen production by droplet-based microbial micro-reactors under aerobic conditions
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-25
    Zhijun Xu; Shengliang Wang; Chunyu Zhao; Shangsong Li; Xiaoman Liu; Lei Wang; Mei Li; Xin Huang; Stephen Mann

    The spontaneous self-assembly of multicellular ensembles into living materials with synergistic structure and function remains a considerable challenge in biotechnology and synthetic biology. Here, we exploit the aqueous two-phase separation of dextran-in-PEG emulsion micro-droplets for the capture, spatial organization and immobilization of algal cells or algal/bacterial cell communities to produce

    更新日期:2020-11-26
  • Structural basis for inhibition of an archaeal CRISPR–Cas type I-D large subunit by an anti-CRISPR protein
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-25
    M. Cemre Manav; Lan B. Van; Jinzhong Lin; Anders Fuglsang; Xu Peng; Ditlev E. Brodersen

    A hallmark of type I CRISPR–Cas systems is the presence of Cas3, which contains both the nuclease and helicase activities required for DNA cleavage during interference. In subtype I-D systems, however, the histidine-aspartate (HD) nuclease domain is encoded as part of a Cas10-like large effector complex subunit and the helicase activity in a separate Cas3’ subunit, but the functional and mechanistic

    更新日期:2020-11-26
  • Parabrachial nucleus circuit governs neuropathic pain-like behavior
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-25
    Li Sun; Rui Liu; Fang Guo; Man-qing Wen; Xiao-lin Ma; Kai-yuan Li; Hao Sun; Ceng-lin Xu; Yuan-yuan Li; Meng-yin Wu; Zheng-gang Zhu; Xin-jian Li; Yan-qin Yu; Zhong Chen; Xiang-yao Li; Shumin Duan

    The lateral parabrachial nucleus (LPBN) is known to relay noxious information to the amygdala for processing affective responses. However, it is unclear whether the LPBN actively processes neuropathic pain characterized by persistent hyperalgesia with aversive emotional responses. Here we report that neuropathic pain-like hypersensitivity induced by common peroneal nerve (CPN) ligation increases nociceptive

    更新日期:2020-11-26
  • Cellular and gene signatures of tumor-infiltrating dendritic cells and natural-killer cells predict prognosis of neuroblastoma
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-25
    Ombretta Melaiu; Marco Chierici; Valeria Lucarini; Giuseppe Jurman; Libenzio Adrian Conti; Rita De Vito; Renata Boldrini; Loredana Cifaldi; Aurora Castellano; Cesare Furlanello; Vincenzo Barnaba; Franco Locatelli; Doriana Fruci

    Tumor-infiltrating lymphocytes play an essential role in improving clinical outcome of neuroblastoma (NB) patients, but their relationship with other tumor-infiltrating immune cells in the T cell-inflamed tumors remains poorly investigated. Here we show that dendritic cells (DCs) and natural killer (NK) cells are positively correlated with T-cell infiltration in human NB, both at transcriptional and

    更新日期:2020-11-26
  • Spatial proteomics defines the content of trafficking vesicles captured by golgin tethers
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-25
    John J. H. Shin; Oliver M. Crook; Alicia C. Borgeaud; Jérôme Cattin-Ortolá; Sew Y. Peak-Chew; Lisa M. Breckels; Alison K. Gillingham; Jessica Chadwick; Kathryn S. Lilley; Sean Munro

    Intracellular traffic between compartments of the secretory and endocytic pathways is mediated by vesicle-based carriers. The proteomes of carriers destined for many organelles are ill-defined because the vesicular intermediates are transient, low-abundance and difficult to purify. Here, we combine vesicle relocalisation with organelle proteomics and Bayesian analysis to define the content of different

    更新日期:2020-11-26
  • Remote near infrared identification of pathogens with multiplexed nanosensors
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-25
    Robert Nißler; Oliver Bader; Maria Dohmen; Sebastian G. Walter; Christine Noll; Gabriele Selvaggio; Uwe Groß; Sebastian Kruss

    Infectious diseases are worldwide a major cause of morbidity and mortality. Fast and specific detection of pathogens such as bacteria is needed to combat these diseases. Optimal methods would be non-invasive and without extensive sample-taking/processing. Here, we developed a set of near infrared (NIR) fluorescent nanosensors and used them for remote fingerprinting of clinically important bacteria

    更新日期:2020-11-26
  • Wisp1 is a circulating factor that stimulates proliferation of adult mouse and human beta cells
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-25
    Rebeca Fernandez-Ruiz; Ainhoa García-Alamán; Yaiza Esteban; Joan Mir-Coll; Berta Serra-Navarro; Marta Fontcuberta-PiSunyer; Christophe Broca; Mathieu Armanet; Anne Wojtusciszyn; Vardit Kram; Marian F. Young; Josep Vidal; Ramon Gomis; Rosa Gasa

    Expanding the mass of pancreatic insulin-producing beta cells through re-activation of beta cell replication has been proposed as a therapy to prevent or delay the appearance of diabetes. Pancreatic beta cells exhibit an age-dependent decrease in their proliferative activity, partly related to changes in the systemic environment. Here we report the identification of CCN4/Wisp1 as a circulating factor

    更新日期:2020-11-26
  • Iceberg melting substantially modifies oceanic heat flux towards a major Greenlandic tidewater glacier
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-25
    B. J. Davison; T. R. Cowton; F. R. Cottier; A. J. Sole

    Fjord dynamics influence oceanic heat flux to the Greenland ice sheet. Submarine iceberg melting releases large volumes of freshwater within Greenland’s fjords, yet its impact on fjord dynamics remains unclear. We modify an ocean model to simulate submarine iceberg melting in Sermilik Fjord, east Greenland. Here we find that submarine iceberg melting cools and freshens the fjord by up to ~5 °C and

    更新日期:2020-11-26
  • A versatile and customizable low-cost 3D-printed open standard for microscopic imaging
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-25
    Benedict Diederich; René Lachmann; Swen Carlstedt; Barbora Marsikova; Haoran Wang; Xavier Uwurukundo; Alexander S. Mosig; Rainer Heintzmann

    Modern microscopes used for biological imaging often present themselves as black boxes whose precise operating principle remains unknown, and whose optical resolution and price seem to be in inverse proportion to each other. With UC2 (You. See. Too.) we present a low-cost, 3D-printed, open-source, modular microscopy toolbox and demonstrate its versatility by realizing a complete microscope development

    更新日期:2020-11-26
  • Prevention of CaCl 2 -induced aortic inflammation and subsequent aneurysm formation by the CCL3–CCR5 axis
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-25
    Yuko Ishida; Yumi Kuninaka; Mizuho Nosaka; Akihiko Kimura; Akira Taruya; Machi Furuta; Naofumi Mukaida; Toshikazu Kondo

    Inflammatory mediators such as cytokines and chemokines are crucially involved in the development of abdominal aortic aneurysm (AAA). Here we report that CaCl2 application into abdominal aorta induces AAA with intra-aortic infiltration of macrophages as well as enhanced expression of chemokine (C-C motif) ligand 3 (CCL3) and MMP-9. Moreover, infiltrating macrophages express C-C chemokine receptor 5

    更新日期:2020-11-26
  • Author Correction: Interactions with conspecific outsiders as drivers of cognitive evolution
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-24
    Benjamin J. Ashton; Patrick Kennedy; Andrew N. Radford

    A Correction to this paper has been published: https://doi.org/10.1038/s41467-020-20090-7

    更新日期:2020-11-25
  • Author Correction: Antibiotic susceptibility signatures identify potential antimicrobial targets in the Acinetobacter baumannii cell envelope
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-24
    Edward Geisinger; Nadav J. Mortman; Yunfei Dai; Murat Cokol; Sapna Syal; Andrew Farinha; Delaney G. Fisher; Amy Y. Tang; David W. Lazinski; Stephen Wood; Jon Anthony; Tim van Opijnen; Ralph R. Isberg

    A Correction to this paper has been published: https://doi.org/10.1038/s41467-020-20098-z

    更新日期:2020-11-25
  • Author Correction: Enhancement of trans-cleavage activity of Cas12a with engineered crRNA enables amplified nucleic acid detection
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-24
    Long T. Nguyen; Brianna M. Smith; Piyush K. Jain

    A Correction to this paper has been published: https://doi.org/10.1038/s41467-020-20117-z

    更新日期:2020-11-25
  • Sub-wavelength lateral detection of tissue-approximating masses using an ultrasonic metamaterial lens
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-24
    Ezekiel L. Walker; Yuqi Jin; Delfino Reyes; Arup Neogi

    Practically applied techniques for ultrasonic biomedical imaging employ delay-and-sum (DAS) beamforming which can resolve two objects down to 2.1λ within the acoustic Fresnel zone. Here, we demonstrate a phononic metamaterial lens (ML) for detection of laterally subwavelength object features in tissue-like phantoms beyond the phononic crystal evanescent zone and Fresnel zone of the emitter. The ML

    更新日期:2020-11-25
  • Recent evolution of a TET-controlled and DPPA3/STELLA-driven pathway of passive DNA demethylation in mammals
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-24
    Christopher B. Mulholland; Atsuya Nishiyama; Joel Ryan; Ryohei Nakamura; Merve Yiğit; Ivo M. Glück; Carina Trummer; Weihua Qin; Michael D. Bartoschek; Franziska R. Traube; Edris Parsa; Enes Ugur; Miha Modic; Aishwarya Acharya; Paul Stolz; Christoph Ziegenhain; Michael Wierer; Wolfgang Enard; Thomas Carell; Don C. Lamb; Hiroyuki Takeda; Makoto Nakanashi; Sebastian Bultmann; Heinrich Leonhardt

    Genome-wide DNA demethylation is a unique feature of mammalian development and naïve pluripotent stem cells. Here, we describe a recently evolved pathway in which global hypomethylation is achieved by the coupling of active and passive demethylation. TET activity is required, albeit indirectly, for global demethylation, which mostly occurs at sites devoid of TET binding. Instead, TET-mediated active

    更新日期:2020-11-25
  • Molecular basis of EphA2 recognition by gHgL from gammaherpesviruses
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-24
    Chao Su; Lili Wu; Yan Chai; Jianxun Qi; Shuguang Tan; George F. Gao; Hao Song; Jinghua Yan

    The human γ-herpesviruses Kaposi sarcoma associated herpesvirus (KSHV) and Epstein-Barr virus (EBV) are associated with many human malignancies. Viral glycoprotein H (gH) and glycoprotein L (gL) are crucial for the cell tropism by binding to specific receptors. Recently, EphA2 was identified as the specific entry receptor for both KSHV and EBV. Here, we characterized the crystal structures of KSHV

    更新日期:2020-11-25
  • HLH-11 modulates lipid metabolism in response to nutrient availability
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-24
    Yi Li; Wanqiu Ding; Chuan-Yun Li; Ying Liu

    The ability of organisms to sense nutrient availability and tailor their metabolic states to withstand nutrient deficiency is critical for survival. To identify previously unknown regulators that couple nutrient deficiency to body fat utilization, we performed a cherry-picked RNAi screen in C. elegans and found that the transcription factor HLH-11 regulates lipid metabolism in response to food availability

    更新日期:2020-11-25
  • Intestinal FGF15/19 physiologically repress hepatic lipogenesis in the late fed-state by activating SHP and DNMT3A
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-24
    Young-Chae Kim; Sunmi Seok; Yang Zhang; Jian Ma; Bo Kong; Grace Guo; Byron Kemper; Jongsook Kim Kemper

    Hepatic lipogenesis is normally tightly regulated but is aberrantly elevated in obesity. Fibroblast Growth Factor-15/19 (mouse FGF15, human FGF19) are bile acid-induced late fed-state gut hormones that decrease hepatic lipid levels by unclear mechanisms. We show that FGF15/19 and FGF15/19-activated Small Heterodimer Partner (SHP/NR0B2) have a role in transcriptional repression of lipogenesis. Comparative

    更新日期:2020-11-25
  • Epigenome-wide meta-analysis of PTSD across 10 military and civilian cohorts identifies methylation changes in AHRR
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-24
    Alicia K. Smith; Andrew Ratanatharathorn; Adam X. Maihofer; Robert K. Naviaux; Allison E. Aiello; Ananda B. Amstadter; Allison E. Ashley-Koch; Dewleen G. Baker; Jean C. Beckham; Marco P. Boks; Evelyn Bromet; Michelle Dennis; Sandro Galea; Melanie E. Garrett; Elbert Geuze; Guia Guffanti; Michael A. Hauser; Seyma Katrinli; Varun Kilaru; Ronald C. Kessler; Nathan A. Kimbrel; Karestan C. Koenen; Pei-Fen

    Epigenetic differences may help to distinguish between PTSD cases and trauma-exposed controls. Here, we describe the results of the largest DNA methylation meta-analysis of PTSD to date. Ten cohorts, military and civilian, contribute blood-derived DNA methylation data from 1,896 PTSD cases and trauma-exposed controls. Four CpG sites within the aryl-hydrocarbon receptor repressor (AHRR) associate with

    更新日期:2020-11-25
  • Global hotspots for the occurrence of compound events
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-24
    Nina N. Ridder; Andy J. Pitman; Seth Westra; Anna Ukkola; X. Do Hong; Margot Bador; Annette L. Hirsch; Jason P. Evans; Alejandro Di Luca; Jakob Zscheischler

    Compound events (CEs) are weather and climate events that result from multiple hazards or drivers with the potential to cause severe socio-economic impacts. Compared with isolated hazards, the multiple hazards/drivers associated with CEs can lead to higher economic losses and death tolls. Here, we provide the first analysis of multiple multivariate CEs potentially causing high-impact floods, droughts

    更新日期:2020-11-25
  • 2D atomic crystal molecular superlattices by soft plasma intercalation
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-24
    Lufang Zhang; Haiyan Nan; Xiumei Zhang; Qifeng Liang; Aijun Du; Zhenhua Ni; Xiaofeng Gu; Kostya (Ken) Ostrikov; Shaoqing Xiao

    Two-dimensional (2D) atomic crystal superlattices integrate diverse 2D layered materials enabling adjustable electronic and optical properties. However, tunability of the interlayer gap and interactions remain challenging. Here we report a solution based on soft oxygen plasma intercalation. 2D atomic crystal molecular superlattices (ACMSs) are produced by intercalating O2+ ions into the interlayer

    更新日期:2020-11-25
  • Common diseases alter the physiological age-related blood microRNA profile
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-24
    Tobias Fehlmann; Benoit Lehallier; Nicholas Schaum; Oliver Hahn; Mustafa Kahraman; Yongping Li; Nadja Grammes; Lars Geffers; Christina Backes; Rudi Balling; Fabian Kern; Rejko Krüger; Frank Lammert; Nicole Ludwig; Benjamin Meder; Bastian Fromm; Walter Maetzler; Daniela Berg; Kathrin Brockmann; Christian Deuschle; Anna-Katharina von Thaler; Gerhard W. Eschweiler; Sofiya Milman; Nir Barziliai; Matthias

    Aging is a key risk factor for chronic diseases of the elderly. MicroRNAs regulate post-transcriptional gene silencing through base-pair binding on their target mRNAs. We identified nonlinear changes in age-related microRNAs by analyzing whole blood from 1334 healthy individuals. We observed a larger influence of the age as compared to the sex and provide evidence for a shift to the 5’ mature form

    更新日期:2020-11-25
  • Biomineral armor in leaf-cutter ants
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-24
    Hongjie Li; Chang-Yu Sun; Yihang Fang; Caitlin M. Carlson; Huifang Xu; Ana Ješovnik; Jeffrey Sosa-Calvo; Robert Zarnowski; Hans A. Bechtel; John H. Fournelle; David R. Andes; Ted R. Schultz; Pupa U. P. A. Gilbert; Cameron R. Currie

    Although calcareous anatomical structures have evolved in diverse animal groups, such structures have been unknown in insects. Here, we report the discovery of high-magnesium calcite [CaMg(CO3)2] armor overlaying the exoskeletons of major workers of the leaf-cutter ant Acromyrmex echinatior. Live-rearing and in vitro synthesis experiments indicate that the biomineral layer accumulates rapidly as ant

    更新日期:2020-11-25
  • Horizontally acquired papGII -containing pathogenicity islands underlie the emergence of invasive uropathogenic Escherichia coli lineages
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-24
    Michael Biggel; Basil B. Xavier; James R. Johnson; Karen L. Nielsen; Niels Frimodt-Møller; Veerle Matheeussen; Herman Goossens; Pieter Moons; Sandra Van Puyvelde

    Escherichia coli is the leading cause of urinary tract infection, one of the most common bacterial infections in humans. Despite this, a genomic perspective is lacking regarding the phylogenetic distribution of isolates associated with different clinical syndromes. Here, we present a large-scale phylogenomic analysis of a spatiotemporally and clinically diverse set of 907 E. coli isolates, including

    更新日期:2020-11-25
  • Prospects and challenges for squeezing-enhanced optical atomic clocks
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-24
    Marius Schulte; Christian Lisdat; Piet O. Schmidt; Uwe Sterr; Klemens Hammerer

    Optical atomic clocks are a driving force for precision measurements due to the high accuracy and stability demonstrated in recent years. While further improvements to the stability have been envisioned by using entangled atoms, squeezing the quantum mechanical projection noise, evaluating the overall gain must incorporate essential features of an atomic clock. Here, we investigate the benefits of

    更新日期:2020-11-25
  • Endocannabinoid signaling regulates the reinforcing and psychostimulant effects of ketamine in mice
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-24
    Wei Xu; Hongchun Li; Liang Wang; Jiamei Zhang; Chunqi Liu; Xuemei Wan; Xiaochong Liu; Yiming Hu; Qiyao Fang; Yuanyuan Xiao; Qian Bu; Hongbo Wang; Jingwei Tian; Yinglan Zhao; Xiaobo Cen

    The abuse potential of ketamine limits its clinical application, but the precise mechanism remains largely unclear. Here we discovered that ketamine significantly remodels the endocannabinoid-related lipidome and activates 2-arachidonoylglycerol (2-AG) signaling in the dorsal striatum (caudate nucleus and putamen, CPu) of mice. Elevated 2-AG in the CPu is essential for the psychostimulant and reinforcing

    更新日期:2020-11-25
  • On-the-fly closed-loop materials discovery via Bayesian active learning
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-24
    A. Gilad Kusne; Heshan Yu; Changming Wu; Huairuo Zhang; Jason Hattrick-Simpers; Brian DeCost; Suchismita Sarker; Corey Oses; Cormac Toher; Stefano Curtarolo; Albert V. Davydov; Ritesh Agarwal; Leonid A. Bendersky; Mo Li; Apurva Mehta; Ichiro Takeuchi

    Active learning—the field of machine learning (ML) dedicated to optimal experiment design—has played a part in science as far back as the 18th century when Laplace used it to guide his discovery of celestial mechanics. In this work, we focus a closed-loop, active learning-driven autonomous system on another major challenge, the discovery of advanced materials against the exceedingly complex synthe

    更新日期:2020-11-25
  • Shape-preserving erosion controlled by the graded microarchitecture of shark tooth enameloid
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-24
    Shahrouz Amini; Hajar Razi; Ronald Seidel; Daniel Werner; William T. White; James C. Weaver; Mason N. Dean; Peter Fratzl

    The teeth of all vertebrates predominantly comprise the same materials, but their lifespans vary widely: in stark contrast to mammals, shark teeth are functional only for weeks, rather than decades, making lifelong durability largely irrelevant. However, their diets are diverse and often mechanically demanding, and as such, their teeth should maintain a functional morphology, even in the face of extremely

    更新日期:2020-11-25
  • Synthetic protein-binding DNA sponge as a tool to tune gene expression and mitigate protein toxicity
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-24
    Xinyi Wan; Filipe Pinto; Luyang Yu; Baojun Wang

    Versatile tools for gene expression regulation are vital for engineering gene networks of increasing scales and complexity with bespoke responses. Here, we investigate and repurpose a ubiquitous, indirect gene regulation mechanism from nature, which uses decoy protein-binding DNA sites, named DNA sponge, to modulate target gene expression in Escherichia coli. We show that synthetic DNA sponges can

    更新日期:2020-11-25
  • High-throughput laboratory evolution reveals evolutionary constraints in Escherichia coli
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-24
    Tomoya Maeda; Junichiro Iwasawa; Hazuki Kotani; Natsue Sakata; Masako Kawada; Takaaki Horinouchi; Aki Sakai; Kumi Tanabe; Chikara Furusawa

    Understanding the constraints that shape the evolution of antibiotic resistance is critical for predicting and controlling drug resistance. Despite its importance, however, a systematic investigation of evolutionary constraints is lacking. Here, we perform a high-throughput laboratory evolution of Escherichia coli under the addition of 95 antibacterial chemicals and quantified the transcriptome, resistance

    更新日期:2020-11-25
  • Mechanically interlocked 3D multi-material micromachines
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-24
    C. C. J. Alcântara; F. C. Landers; S. Kim; C. De Marco; D. Ahmed; B. J. Nelson; S. Pané

    Metals and polymers are dissimilar materials in terms of their physicochemical properties, but complementary in terms of functionality. As a result, metal-organic structures can introduce a wealth of novel applications in small-scale robotics. However, current fabrication techniques are unable to process three-dimensional metallic and polymeric components. Here, we show that hybrid microstructures

    更新日期:2020-11-25
  • Population-scale study of eRNA transcription reveals bipartite functional enhancer architecture
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-24
    Katla Kristjánsdóttir; Alexis Dziubek; Hyun Min Kang; Hojoong Kwak

    Enhancer RNAs (eRNA) are unstable non-coding RNAs, transcribed bidirectionally from active regulatory sequences, whose expression levels correlate with enhancer activity. We use capped-nascent-RNA sequencing to efficiently capture bidirectional transcription initiation across several human lymphoblastoid cell lines (Yoruba population) and detect ~75,000 eRNA transcription sites with high sensitivity

    更新日期:2020-11-25
  • Publisher Correction: Parallel evolution in the emergence of highly pathogenic avian influenza A viruses
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-23
    Marina Escalera-Zamudio; Michael Golden; Bernardo Gutiérrez; Julien Thézé; Jeremy Russell Keown; Loic Carrique; Thomas A. Bowden; Oliver G. Pybus

    A Correction to this paper has been published: https://doi.org/10.1038/s41467-020-20006-5

    更新日期:2020-11-23
  • Publisher Correction: Oncogenic hijacking of a developmental transcription factor evokes vulnerability toward oxidative stress in Ewing sarcoma
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-23
    Aruna Marchetto; Shunya Ohmura; Martin F. Orth; Maximilian M. L. Knott; Maria V. Colombo; Chiara Arrigoni; Victor Bardinet; David Saucier; Fabienne S. Wehweck; Jing Li; Stefanie Stein; Julia S. Gerke; Michaela C. Baldauf; Julian Musa; Marlene Dallmayer; Laura Romero-Pérez; Tilman L. B. Hölting; James F. Amatruda; Andrea Cossarizza; Anton G. Henssen; Thomas Kirchner; Matteo Moretti; Florencia Cidre-Aranaz;

    A Correction to this paper has been published: https://doi.org/10.1038/s41467-020-20017-2

    更新日期:2020-11-23
  • Structural basis for assembly of non-canonical small subunits into type I-C Cascade
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-23
    Roisin E. O’Brien; Inês C. Santos; Daniel Wrapp; Jack P. K. Bravo; Evan A. Schwartz; Jennifer S. Brodbelt; David W. Taylor

    Bacteria and archaea employ CRISPR (clustered, regularly, interspaced, short palindromic repeats)-Cas (CRISPR-associated) systems as a type of adaptive immunity to target and degrade foreign nucleic acids. While a myriad of CRISPR-Cas systems have been identified to date, type I-C is one of the most commonly found subtypes in nature. Interestingly, the type I-C system employs a minimal Cascade effector

    更新日期:2020-11-23
  • Ni-catalyzed asymmetric hydrogenation of N -aryl imino esters for the efficient synthesis of chiral α-aryl glycines
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-23
    Dan Liu; Bowen Li; Jianzhong Chen; Ilya D. Gridnev; Deyue Yan; Wanbin Zhang

    Chiral α-aryl glycines play a key role in the preparation of some bioactive products, however, their catalytic asymmetric synthesis is far from being satisfactory. Herein, we report an efficient nickel-catalyzed asymmetric hydrogenation of N-aryl imino esters, affording chiral α-aryl glycines in high yields and enantioselectivities (up to 98% ee). The hydrogenation can be conducted on a gram scale

    更新日期:2020-11-23
  • A few basic concepts in electrochemical carbon dioxide reduction
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-23
    Karen Chan

    In this perspective, I discuss a few basic concepts in fundamental mechanistic studies of electrochemical carbon dioxide reduction. Electrochemical carbon dioxide (CO2) reduction has the potential to sustainably produce carbon-based fuels and chemicals while mitigating the increasing levels of CO2 in the atmosphere. In this comment, the author discusses a few basic concepts in the fundamental mechanistic

    更新日期:2020-11-23
  • Synthesis and X-ray characterization of 15- and 16-vertex closo -carboranes
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-23
    Fangrui Zheng; Tsz Hin Yui; Jiji Zhang; Zuowei Xie

    Carboranes are a class of carbon-boron molecular clusters with three-dimensional aromaticity, and inherent robustness. These endowments enable carboranes as valuable building blocks for applications ranging from functional materials to pharmaceuticals. Thus, the chemistry of carboranes has received tremendous research interest, and significant progress has been made in the past decades. However, many

    更新日期:2020-11-23
  • Nanoparticles suppress fluid instabilities in the thermal drawing of ultralong nanowires
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-23
    Injoo Hwang; Zeyi Guan; Chezheng Cao; Wenliang Tang; Chi On Chui; Xiaochun Li

    Ultra-long metal nanowires and their facile fabrication have been long sought after as they promise to offer substantial improvements of performance in numerous applications. However, ultra-long metal ultrafine/nanowires are beyond the capability of current manufacturing techniques, which impose limitations on their size and aspect ratio. Here we show that the limitations imposed by fluid instabilities

    更新日期:2020-11-23
  • Imaging the coupling between itinerant electrons and localised moments in the centrosymmetric skyrmion magnet GdRu 2 Si 2
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-23
    Yuuki Yasui; Christopher J. Butler; Nguyen Duy Khanh; Satoru Hayami; Takuya Nomoto; Tetsuo Hanaguri; Yukitoshi Motome; Ryotaro Arita; Taka-hisa Arima; Yoshinori Tokura; Shinichiro Seki

    Magnetic skyrmions were thought to be stabilised only in inversion-symmetry breaking structures, but skyrmion lattices were recently discovered in inversion symmetric Gd-based compounds, spurring questions of the stabilisation mechanism. A natural consequence of a recent theoretical proposal, a coupling between itinerant electrons and localised magnetic moments, is that the skyrmions are amenable to

    更新日期:2020-11-23
  • High-performance compliant thermoelectric generators with magnetically self-assembled soft heat conductors for self-powered wearable electronics
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-23
    Byeongmoon Lee; Hyeon Cho; Kyung Tae Park; Jin-Sang Kim; Min Park; Heesuk Kim; Yongtaek Hong; Seungjun Chung

    Softening of thermoelectric generators facilitates conformal contact with arbitrary-shaped heat sources, which offers an opportunity to realize self-powered wearable applications. However, existing wearable thermoelectric devices inevitably exhibit reduced thermoelectric conversion efficiency due to the parasitic heat loss in high-thermal-impedance polymer substrates and poor thermal contact arising

    更新日期:2020-11-23
  • Prebiotically-relevant low polyion multivalency can improve functionality of membraneless compartments
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-23
    Fatma Pir Cakmak; Saehyun Choi; McCauley O. Meyer; Philip C. Bevilacqua; Christine D. Keating

    Multivalent polyions can undergo complex coacervation, producing membraneless compartments that accumulate ribozymes and enhance catalysis, and offering a mechanism for functional prebiotic compartmentalization in the origins of life. Here, we evaluate the impact of lower, more prebiotically-relevant, polyion multivalency on the functional performance of coacervates as compartments. Positively and

    更新日期:2020-11-23
  • Surveying biomolecular frustration at atomic resolution
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-23
    Mingchen Chen; Xun Chen; Nicholas P. Schafer; Cecilia Clementi; Elizabeth A. Komives; Diego U. Ferreiro; Peter G. Wolynes

    To function, biomolecules require sufficient specificity of interaction as well as stability to live in the cell while still being able to move. Thermodynamic stability of only a limited number of specific structures is important so as to prevent promiscuous interactions. The individual interactions in proteins, therefore, have evolved collectively to give funneled minimally frustrated landscapes but

    更新日期:2020-11-23
  • Universal light-guiding geometry for on-chip resonators having extremely high Q-factor
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-23
    Dae-Gon Kim; Sangyoon Han; Joonhyuk Hwang; In Hwan Do; Dongin Jeong; Ji-Hun Lim; Yong-Hoon Lee; Muhan Choi; Yong-Hee Lee; Duk-Yong Choi; Hansuek Lee

    By providing an effective way to leverage nonlinear phenomena in integrated devices, high-Q optical resonators have led to recent advances in on-chip photonics. However, developing fabrication processes to shape any new material into a resonator with extremely smooth surfaces on a chip has been an exceptionally challenging task. Here, we describe a universal method to implement ultra-high-Q resonators

    更新日期:2020-11-23
  • Common and distinct neural representations of aversive somatic and visceral stimulation in healthy individuals
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-23
    Lukas Van Oudenhove; Philip A. Kragel; Patrick Dupont; Huynh Giao Ly; Els Pazmany; Paul Enzlin; Amandine Rubio; Chantal Delon-Martin; Bruno Bonaz; Qasim Aziz; Jan Tack; Shin Fukudo; Michiko Kano; Tor D. Wager

    Different pain types may be encoded in different brain circuits. Here, we examine similarities and differences in brain processing of visceral and somatic pain. We analyze data from seven fMRI studies (N = 165) and five types of pain and discomfort (esophageal, gastric, and rectal distension, cutaneous thermal stimulation, and vulvar pressure) to establish and validate generalizable pain representations

    更新日期:2020-11-23
  • Altered conformational sampling along an evolutionary trajectory changes the catalytic activity of an enzyme
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-23
    Joe A. Kaczmarski; Mithun C. Mahawaththa; Akiva Feintuch; Ben E. Clifton; Luke A. Adams; Daniella Goldfarb; Gottfried Otting; Colin J. Jackson

    Several enzymes are known to have evolved from non-catalytic proteins such as solute-binding proteins (SBPs). Although attention has been focused on how a binding site can evolve to become catalytic, an equally important question is: how do the structural dynamics of a binding protein change as it becomes an efficient enzyme? Here we performed a variety of experiments, including propargyl-DO3A-Gd(III)

    更新日期:2020-11-23
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