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  • Publisher Correction: Controllability governs the balance between Pavlovian and instrumental action selection
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-08
    Hayley M. Dorfman; Samuel J. Gershman

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

    更新日期:2020-07-08
  • Publisher Correction: Hydrolase–like catalysis and structural resolution of natural products by a metal–organic framework
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-08
    Marta Mon; Rosaria Bruno; Sergio Sanz-Navarro; Cristina Negro; Jesús Ferrando-Soria; Lucia Bartella; Leonardo Di Donna; Mario Prejanò; Tiziana Marino; Antonio Leyva-Pérez; Donatella Armentano; Emilio Pardo

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

    更新日期:2020-07-08
  • Author Correction: In-cell identification and measurement of RNA-protein interactions
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-08
    Antoine Graindorge; Inês Pinheiro; Anna Nawrocka; Allison C. Mallory; Peter Tsvetkov; Noa Gil; Carlo Carolis; Frank Buchholz; Igor Ulitsky; Edith Heard; Mikko Taipale; Alena Shkumatava

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

    更新日期:2020-07-08
  • Author Correction: Land-use change interacts with climate to determine elevational species redistribution
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-08
    Fengyi Guo; Jonathan Lenoir; Timothy C. Bonebrake

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

    更新日期:2020-07-08
  • SARS-CoV-2 is transmitted via contact and via the air between ferrets
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-08
    Mathilde Richard; Adinda Kok; Dennis de Meulder; Theo M. Bestebroer; Mart M. Lamers; Nisreen M. A. Okba; Martje Fentener van Vlissingen; Barry Rockx; Bart L. Haagmans; Marion P. G. Koopmans; Ron A. M. Fouchier; Sander Herfst

    SARS-CoV-2, a coronavirus that emerged in late 2019, has spread rapidly worldwide, and information about the modes of transmission of SARS-CoV-2 among humans is critical to apply appropriate infection control measures and to slow its spread. Here we show that SARS-CoV-2 is transmitted efficiently via direct contact and via the air (via respiratory droplets and/or aerosols) between ferrets, 1 to 3 days

    更新日期:2020-07-08
  • Light phase detection with on-chip petahertz electronic networks
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-08
    Yujia Yang; Marco Turchetti; Praful Vasireddy; William P. Putnam; Oliver Karnbach; Alberto Nardi; Franz X. Kärtner; Karl K. Berggren; Phillip D. Keathley

    Ultrafast, high-intensity light-matter interactions lead to optical-field-driven photocurrents with an attosecond-level temporal response. These photocurrents can be used to detect the carrier-envelope-phase (CEP) of short optical pulses, and enable optical-frequency, petahertz (PHz) electronics for high-speed information processing. Despite recent reports on optical-field-driven photocurrents in various

    更新日期:2020-07-08
  • Unveiling hydrocerussite as an electrochemically stable active phase for efficient carbon dioxide electroreduction to formate
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-08
    Yanmei Shi; Yan Ji; Jun Long; Yu Liang; Yang Liu; Yifu Yu; Jianping Xiao; Bin Zhang

    For most metal-containing CO2 reduction reaction (CO2RR) electrocatalysts, the unavoidable self-reduction to zero-valence metal will promote hydrogen evolution, hence lowering the CO2RR selectivity. Thus it is challenging to design a stable phase with resistance to electrochemical self-reduction as well as high CO2RR activity. Herein, we report a scenario to develop hydrocerussite as a stable and active

    更新日期:2020-07-08
  • Hybrid plasmonic nano-emitters with controlled single quantum emitter positioning on the local excitation field
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-08
    Dandan Ge; Sylvie Marguet; Ali Issa; Safi Jradi; Tien Hoa Nguyen; Mackrine Nahra; Jéremie Béal; Régis Deturche; Hongshi Chen; Sylvain Blaize; Jérôme Plain; Céline Fiorini; Ludovic Douillard; Olivier Soppera; Xuan Quyen Dinh; Cuong Dang; Xuyong Yang; Tao Xu; Bin Wei; Xiao Wei Sun; Christophe Couteau; Renaud Bachelot

    Hybrid plasmonic nano-emitters based on the combination of quantum dot emitters (QD) and plasmonic nanoantennas open up new perspectives in the control of light. However, precise positioning of any active medium at the nanoscale constitutes a challenge. Here, we report on the optimal overlap of antenna’s near-field and active medium whose spatial distribution is controlled via a plasmon-triggered 2-photon

    更新日期:2020-07-08
  • Quantum-dot assisted spectroscopy of degeneracy-lifted Landau levels in graphene
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-08
    Itai Keren; Tom Dvir; Ayelet Zalic; Amir Iluz; David LeBoeuf; Kenji Watanabe; Takashi Taniguchi; Hadar Steinberg

    Energy spectroscopy of strongly interacting phases requires probes which minimize screening while retaining spectral resolution and local sensitivity. Here, we demonstrate that such probes can be realized using atomic sized quantum dots bound to defects in hexagonal Boron Nitride tunnel barriers, placed at nanometric distance from graphene. With dot energies capacitively tuned by a planar graphite

    更新日期:2020-07-08
  • Highly reversible oxygen redox in layered compounds enabled by surface polyanions
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-08
    Qing Chen; Yi Pei; Houwen Chen; Yan Song; Liang Zhen; Cheng-Yan Xu; Penghao Xiao; Graeme Henkelman

    Oxygen-anion redox in lithium-rich layered oxides can boost the capacity of lithium-ion battery cathodes. However, the over-oxidation of oxygen at highly charged states aggravates irreversible structure changes and deteriorates cycle performance. Here, we investigate the mechanism of surface degradation caused by oxygen oxidation and the kinetics of surface reconstruction. Considering Li2MnO3, we show

    更新日期:2020-07-08
  • κB-Ras and Ral GTPases regulate acinar to ductal metaplasia during pancreatic adenocarcinoma development and pancreatitis
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-08
    Stephanie Beel; Lina Kolloch; Lisa H. Apken; Lara Jürgens; Andrea Bolle; Nadine Sudhof; Sankar Ghosh; Eva Wardelmann; Michael Meisterernst; Konrad Steinestel; Andrea Oeckinghaus

    Pancreatic ductal adenocarcinoma (PDAC) is associated with high mortality and therapy resistance. Here, we show that low expression of κB-Ras GTPases is frequently detected in PDAC and correlates with higher histologic grade. In a model of KRasG12D-driven PDAC, loss of κB-Ras accelerates tumour development and shortens median survival. κB-Ras deficiency promotes acinar-to-ductal metaplasia (ADM) during

    更新日期:2020-07-08
  • Cholesterol metabolism drives regulatory B cell IL-10 through provision of geranylgeranyl pyrophosphate
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-08
    Jack A. Bibby; Harriet A. Purvis; Thomas Hayday; Anita Chandra; Klaus Okkenhaug; Sofia Rosenzweig; Ivona Aksentijevich; Michael Wood; Helen J. Lachmann; Claudia Kemper; Andrew P. Cope; Esperanza Perucha

    Regulatory B cells restrict immune and inflammatory responses across a number of contexts. This capacity is mediated primarily through the production of IL-10. Here we demonstrate that the induction of a regulatory program in human B cells is dependent on a metabolic priming event driven by cholesterol metabolism. Synthesis of the metabolic intermediate geranylgeranyl pyrophosphate (GGPP) is required

    更新日期:2020-07-08
  • Optical parametric amplification of sub-cycle shortwave infrared pulses
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-08
    Yu-Chieh Lin; Yasuo Nabekawa; Katsumi Midorikawa

    Few–cycle short–wave infrared (SWIR) pulses are useful tools for research on strong–field physics and nonlinear optics. Here we demonstrate the amplification of sub–cycle pulses in the SWIR region by using a cascaded BBO–based optical parametric amplifier (OPA) chain. By virtue of the tailored wavelength of the pump pulse of 708 nm, we successfully obtained a gain bandwidth of more than one octave

    更新日期:2020-07-08
  • Seroprevalence of antibodies against SARS-CoV-2 among health care workers in a large Spanish reference hospital
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-08
    Alberto L. Garcia-Basteiro; Gemma Moncunill; Marta Tortajada; Marta Vidal; Caterina Guinovart; Alfons Jiménez; Rebeca Santano; Sergi Sanz; Susana Méndez; Anna Llupià; Ruth Aguilar; Selena Alonso; Diana Barrios; Carlo Carolis; Pau Cisteró; Eugenia Chóliz; Angeline Cruz; Silvia Fochs; Chenjerai Jairoce; Jochen Hecht; Montserrat Lamoglia; Mikel J. Martínez; Robert A. Mitchell; Natalia Ortega; Nuria Pey;

    Health care workers (HCW) are a high-risk population to acquire SARS-CoV-2 infection from patients or other fellow HCW. This study aims at estimating the seroprevalence against SARS-CoV-2 in a random sample of HCW from a large hospital in Spain. Of the 578 participants recruited from 28 March to 9 April 2020, 54 (9.3%, 95% CI: 7.1–12.0) were seropositive for IgM and/or IgG and/or IgA against SARS-CoV-2

    更新日期:2020-07-08
  • Single-cell RNA-seq reveals that glioblastoma recapitulates a normal neurodevelopmental hierarchy
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-08
    Charles P. Couturier; Shamini Ayyadhury; Phuong U. Le; Javad Nadaf; Jean Monlong; Gabriele Riva; Redouane Allache; Salma Baig; Xiaohua Yan; Mathieu Bourgey; Changseok Lee; Yu Chang David Wang; V. Wee Yong; Marie-Christine Guiot; Hamed Najafabadi; Bratislav Misic; Jack Antel; Guillaume Bourque; Jiannis Ragoussis; Kevin Petrecca

    Cancer stem cells are critical for cancer initiation, development, and treatment resistance. Our understanding of these processes, and how they relate to glioblastoma heterogeneity, is limited. To overcome these limitations, we performed single-cell RNA sequencing on 53586 adult glioblastoma cells and 22637 normal human fetal brain cells, and compared the lineage hierarchy of the developing human brain

    更新日期:2020-07-08
  • Immunological and inflammatory profiles in mild and severe cases of COVID-19
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-08
    Jin-Wen Song; Chao Zhang; Xing Fan; Fan-Ping Meng; Zhe Xu; Peng Xia; Wen-Jing Cao; Tao Yang; Xiao-Peng Dai; Si-Yu Wang; Ruo-Nan Xu; Tian-Jun Jiang; Wen-Gang Li; Da-Wei Zhang; Peng Zhao; Ming Shi; Chiara Agrati; Giuseppe Ippolito; Markus Maeurer; Alimuddin Zumla; Fu-Sheng Wang; Ji-Yuan Zhang

    COVID-19 is associated with 5.1% mortality. Although the virological, epidemiological, clinical, and management outcome features of COVID-19 patients have been defined rapidly, the inflammatory and immune profiles require definition as they influence pathogenesis and clinical expression of COVID-19. Here we show lymphopenia, selective loss of CD4+ T cells, CD8+ T cells and NK cells, excessive T-cell

    更新日期:2020-07-08
  • Author Correction: Response outcomes gate the impact of expectations on perceptual decisions
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-07
    Ainhoa Hermoso-Mendizabal; Alexandre Hyafil; Pavel E. Rueda-Orozco; Santiago Jaramillo; David Robbe; Jaime de la Rocha

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

    更新日期:2020-07-07
  • Publisher Correction: MBNL1 regulates essential alternative RNA splicing patterns in MLL-rearranged leukemia
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-07
    Svetlana S. Itskovich; Arun Gurunathan; Jason Clark; Matthew Burwinkel; Mark Wunderlich; Mikaela R. Berger; Aishwarya Kulkarni; Kashish Chetal; Meenakshi Venkatasubramanian; Nathan Salomonis; Ashish R. Kumar; Lynn H. Lee

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

    更新日期:2020-07-07
  • Author Correction: Benthic fauna declined on a whitening Antarctic continental shelf
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-07
    Santiago E. A. Pineda-Metz; Dieter Gerdes; Claudio Richter

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

    更新日期:2020-07-07
  • Author Correction: Distinct temporal integration of noradrenaline signaling by astrocytic second messengers during vigilance
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-07
    Yuki Oe; Xiaowen Wang; Tommaso Patriarchi; Ayumu Konno; Katsuya Ozawa; Kazuko Yahagi; Hirokazu Hirai; Takashi Tsuboi; Tetsuya Kitaguchi; Lin Tian; Thomas J. McHugh; Hajime Hirase

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

    更新日期:2020-07-07
  • Publisher Correction: Propagation of hippocampal ripples to the neocortex by way of a subiculum-retrosplenial pathway
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-07
    Noam Nitzan; Sam McKenzie; Prateep Beed; Daniel Fine English; Silvia Oldani; John J. Tukker; György Buzsáki; Dietmar Schmitz

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

    更新日期:2020-07-07
  • Interferon-independent STING signaling promotes resistance to HSV-1 in vivo
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-07
    Lívia H. Yamashiro; Stephen C. Wilson; Huntly M. Morrison; Vasiliki Karalis; Jing-Yi J. Chung; Katherine J. Chen; Helen S. Bateup; Moriah L. Szpara; Angus Y. Lee; Jeffery S. Cox; Russell E. Vance

    The Stimulator of Interferon Genes (STING) pathway initiates potent immune responses upon recognition of DNA. To initiate signaling, serine 365 (S365) in the C-terminal tail (CTT) of STING is phosphorylated, leading to induction of type I interferons (IFNs). Additionally, evolutionary conserved responses such as autophagy also occur downstream of STING, but their relative importance during in vivo

    更新日期:2020-07-07
  • Spiking neurons with spatiotemporal dynamics and gain modulation for monolithically integrated memristive neural networks
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-07
    Qingxi Duan; Zhaokun Jing; Xiaolong Zou; Yanghao Wang; Ke Yang; Teng Zhang; Si Wu; Ru Huang; Yuchao Yang

    As a key building block of biological cortex, neurons are powerful information processing units and can achieve highly complex nonlinear computations even in individual cells. Hardware implementation of artificial neurons with similar capability is of great significance for the construction of intelligent, neuromorphic systems. Here, we demonstrate an artificial neuron based on NbOx volatile memristor

    更新日期:2020-07-07
  • Roads as a contributor to landscape-scale variation in bird communities
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-07
    Sophia C. Cooke; Andrew Balmford; Paul F. Donald; Stuart E. Newson; Alison Johnston

    Roads and their traffic can affect wildlife over large areas and, in regions with dense road networks, may influence a high proportion of the ecological landscape. We assess the abundance of 75 bird species in relation to roads across Great Britain. Of these, 77% vary significantly in abundance with increasing road exposure, just over half negatively so. The effect distances of these negative associations

    更新日期:2020-07-07
  • Pathogenic ARH3 mutations result in ADP-ribose chromatin scars during DNA strand break repair
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-07
    Hana Hanzlikova; Evgeniia Prokhorova; Katerina Krejcikova; Zuzana Cihlarova; Ilona Kalasova; Jan Kubovciak; Jana Sachova; Richard Hailstone; Jan Brazina; Shereen Ghosh; Sebahattin Cirak; Joseph G. Gleeson; Ivan Ahel; Keith W. Caldecott

    Neurodegeneration is a common hallmark of individuals with hereditary defects in DNA single-strand break repair; a process regulated by poly(ADP-ribose) metabolism. Recently, mutations in the ARH3 (ADPRHL2) hydrolase that removes ADP-ribose from proteins have been associated with neurodegenerative disease. Here, we show that ARH3-mutated patient cells accumulate mono(ADP-ribose) scars on core histones

    更新日期:2020-07-07
  • Nampt-mediated spindle sizing secures a post-anaphase increase in spindle speed required for extreme asymmetry
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-07
    Zhe Wei; Jessica Greaney; Wei-Guo Nicholas Loh; Hayden Anthony Homer

    Meiotic divisions in oocytes are extremely asymmetric and require pre- and post-anaphase-onset phases of spindle migration. The latter induces membrane protrusion that is moulded around the spindle thereby reducing cytoplasmic loss. Here, we find that depleting the NAD biosynthetic enzyme, nicotinamide phosphoribosyl-transferase (Nampt), in mouse oocytes results in markedly longer spindles and compromises

    更新日期:2020-07-07
  • IgCaller for reconstructing immunoglobulin gene rearrangements and oncogenic translocations from whole-genome sequencing in lymphoid neoplasms
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-07
    Ferran Nadeu; Rut Mas-de-les-Valls; Alba Navarro; Romina Royo; Silvia Martín; Neus Villamor; Helena Suárez-Cisneros; Rosó Mares; Junyan Lu; Anna Enjuanes; Alfredo Rivas-Delgado; Marta Aymerich; Tycho Baumann; Dolors Colomer; Julio Delgado; Ryan D. Morin; Thorsten Zenz; Xose S. Puente; Peter J. Campbell; Sílvia Beà; Francesco Maura; Elías Campo

    Immunoglobulin (Ig) gene rearrangements and oncogenic translocations are routinely assessed during the characterization of B cell neoplasms and stratification of patients with distinct clinical and biological features, with the assessment done using Sanger sequencing, targeted next-generation sequencing, or fluorescence in situ hybridization (FISH). Currently, a complete Ig characterization cannot

    更新日期:2020-07-07
  • Delayed emergence of a global temperature response after emission mitigation
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-07
    B. H. Samset; J. S. Fuglestvedt; M. T. Lund

    A major step towards achieving the goals of the Paris agreement would be a measurable change in the evolution of global warming in response to mitigation of anthropogenic emissions. The inertia and internal variability of the climate system, however, will delay the emergence of a discernible response even to strong, sustained mitigation. Here, we investigate when we could expect a significant change

    更新日期:2020-07-07
  • Two-dimensional halide perovskite as β-ray scintillator for nuclear radiation monitoring
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-07
    Dejian Yu; Peng Wang; Fei Cao; Yu Gu; Jiaxin Liu; Zeyao Han; Bo Huang; Yousheng Zou; Xiaobao Xu; Haibo Zeng

    Ensuring nuclear safety has become of great significance as nuclear power is playing an increasingly important role in supplying worldwide electricity. β-ray monitoring is a crucial method, but commercial organic scintillators for β-ray detection suffer from high temperature failure and irradiation damage. Here, we report a type of β-ray scintillator with good thermotolerance and irradiation hardness

    更新日期:2020-07-07
  • Molecular resolution imaging by post-labeling expansion single-molecule localization microscopy (Ex-SMLM)
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-07
    Fabian U. Zwettler; Sebastian Reinhard; Davide Gambarotto; Toby D. M. Bell; Virginie Hamel; Paul Guichard; Markus Sauer

    Expansion microscopy (ExM) enables super-resolution fluorescence imaging of physically expanded biological samples with conventional microscopes. By combining ExM with single-molecule localization microscopy (SMLM) it is potentially possible to approach the resolution of electron microscopy. However, current attempts to combine both methods remained challenging because of protein and fluorophore loss

    更新日期:2020-07-07
  • Photocatalytic hydrogen peroxide splitting on metal-free powders assisted by phosphoric acid as a stabilizer
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-07
    Yasuhiro Shiraishi; Yuki Ueda; Airu Soramoto; Satoshi Hinokuma; Takayuki Hirai

    Hydrogen peroxide (H2O2) has received increasing attention as an energy carrier. To achieve a sustainable energy society, photocatalytic H2O2 splitting (H2O2 (l) → H2 (g) + O2 (g); ΔG° = + 131 kJ mol−1) is a desirable reaction for on-site H2 generation. However, this reaction has not been reported because conventional photocatalysis decomposes H2O2 by disproportionation (H2O2 (l) → H2O (l) + 1/2O2

    更新日期:2020-07-07
  • Insulators for 2D nanoelectronics: the gap to bridge
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-07
    Yury Yu. Illarionov; Theresia Knobloch; Markus Jech; Mario Lanza; Deji Akinwande; Mikhail I. Vexler; Thomas Mueller; Max C. Lemme; Gianluca Fiori; Frank Schwierz; Tibor Grasser

    Nanoelectronic devices based on 2D materials are far from delivering their full theoretical performance potential due to the lack of scalable insulators. Amorphous oxides that work well in silicon technology have ill-defined interfaces with 2D materials and numerous defects, while 2D hexagonal boron nitride does not meet required dielectric specifications. The list of suitable alternative insulators

    更新日期:2020-07-07
  • Orthophosphate increases the efficiency of slow muscle-myosin isoform in the presence of omecamtiv mecarbil
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-07
    Serena Governali; Marco Caremani; Cristina Gallart; Irene Pertici; Ger Stienen; Gabriella Piazzesi; Coen Ottenheijm; Vincenzo Lombardi; Marco Linari

    Omecamtiv mecarbil (OM) is a putative positive inotropic tool for treatment of systolic heart dysfunction, based on the finding that in vivo it increases the ejection fraction and in vitro it prolongs the actin-bond life time of the cardiac and slow-skeletal muscle isoforms of myosin. OM action in situ, however, is still poorly understood as the enhanced Ca2+-sensitivity of the myofilaments is at odds

    更新日期:2020-07-07
  • R-loop induced G-quadruplex in non-template promotes transcription by successive R-loop formation
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-07
    Chun-Ying Lee; Christina McNerney; Kevin Ma; Walter Zhao; Ashley Wang; Sua Myong

    G-quadruplex (G4) is a noncanonical secondary structure of DNA or RNA which can enhance or repress gene expression, yet the underlying molecular mechanism remains uncertain. Here we show that when positioned downstream of transcription start site, the orientation of potential G4 forming sequence (PQS), but not the sequence alters transcriptional output. Ensemble in vitro transcription assays indicate

    更新日期:2020-07-07
  • Discovery and population genomics of structural variation in a songbird genus
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-07
    Matthias H. Weissensteiner; Ignas Bunikis; Ana Catalán; Kees-Jan Francoijs; Ulrich Knief; Wieland Heim; Valentina Peona; Saurabh D. Pophaly; Fritz J. Sedlazeck; Alexander Suh; Vera M. Warmuth; Jochen B. W. Wolf

    Structural variation (SV) constitutes an important type of genetic mutations providing the raw material for evolution. Here, we uncover the genome-wide spectrum of intra- and interspecific SV segregating in natural populations of seven songbird species in the genus Corvus. Combining short-read (N = 127) and long-read re-sequencing (N = 31), as well as optical mapping (N = 16), we apply both assembly-

    更新日期:2020-07-07
  • The VIP-VPAC2 neuropeptidergic axis is a cellular pacemaking hub of the suprachiasmatic nucleus circadian circuit
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-07
    Andrew P. Patton; Mathew D. Edwards; Nicola J. Smyllie; Ryan Hamnett; Johanna E. Chesham; Marco Brancaccio; Elizabeth S. Maywood; Michael H. Hastings

    The hypothalamic suprachiasmatic nuclei (SCN) are the principal mammalian circadian timekeeper, co-ordinating organism-wide daily and seasonal rhythms. To achieve this, cell-autonomous circadian timing by the ~20,000 SCN cells is welded into a tight circuit-wide ensemble oscillation. This creates essential, network-level emergent properties of precise, high-amplitude oscillation with tightly defined

    更新日期:2020-07-07
  • A nanotrap improves survival in severe sepsis by attenuating hyperinflammation
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-07
    Changying Shi; Xiaojing Wang; Lili Wang; Qinghe Meng; Dandan Guo; Li Chen; Matthew Dai; Guirong Wang; Robert Cooney; Juntao Luo

    Targeting single mediators has failed to reduce the mortality of sepsis. We developed a telodendrimer (TD) nanotrap (NT) to capture various biomolecules via multivalent, hybrid and synergistic interactions. Here, we report that the immobilization of TD-NTs in size-exclusive hydrogel resins simultaneously adsorbs septic molecules, e.g. lipopolysaccharides (LPS), cytokines and damage- or pathogen-associated

    更新日期:2020-07-07
  • Cryo-EM structure of arabinosyltransferase EmbB from Mycobacterium smegmatis
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-07
    Yong Zi Tan; José Rodrigues; James E. Keener; Ruixiang Blake Zheng; Richard Brunton; Brian Kloss; Sabrina I. Giacometti; Ana L. Rosário; Lei Zhang; Michael Niederweis; Oliver B. Clarke; Todd L. Lowary; Michael T. Marty; Margarida Archer; Clinton S. Potter; Bridget Carragher; Filippo Mancia

    Arabinosyltransferase B (EmbB) belongs to a family of membrane-bound glycosyltransferases that build the lipidated polysaccharides of the mycobacterial cell envelope, and are targets of anti-tuberculosis drug ethambutol. We present the 3.3 Å resolution single-particle cryo-electron microscopy structure of Mycobacterium smegmatis EmbB, providing insights on substrate binding and reaction mechanism.

    更新日期:2020-07-07
  • Jawsamycin exhibits in vivo antifungal properties by inhibiting Spt14/Gpi3-mediated biosynthesis of glycosylphosphatidylinositol
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-07
    Yue Fu; David Estoppey; Silvio Roggo; Dominik Pistorius; Florian Fuchs; Christian Studer; Ashraf S. Ibrahim; Thomas Aust; Frederic Grandjean; Manuel Mihalic; Klaus Memmert; Vivian Prindle; Etienne Richard; Ralph Riedl; Sven Schuierer; Eric Weber; Jürg Hunziker; Frank Petersen; Jianshi Tao; Dominic Hoepfner

    Biosynthesis of glycosylphosphatidylinositol (GPI) is required for anchoring proteins to the plasma membrane, and is essential for the integrity of the fungal cell wall. Here, we use a reporter gene-based screen in Saccharomyces cerevisiae for the discovery of antifungal inhibitors of GPI-anchoring of proteins, and identify the oligocyclopropyl-containing natural product jawsamycin (FR-900848) as a

    更新日期:2020-07-07
  • Limited and localized magmatism in the Central Atlantic Magmatic Province
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-07
    R. E. Marzen; D. J. Shillington; D. Lizarralde; J. H. Knapp; D. M. Heffner; J. K. Davis; S. H. Harder

    The Central Atlantic Magmatic Province (CAMP) is the most aerially extensive magmatic event in Earth’s history, but many questions remain about its origin, volume, and distribution. Despite many observations of CAMP magmatism near Earth’s surface, few constraints exist on CAMP intrusions at depth. Here we present detailed constraints on crustal and upper mantle structure from wide-angle seismic data

    更新日期:2020-07-07
  • A user guide for the online exploration and visualization of PCAWG data
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-07
    Mary J. Goldman; Junjun Zhang; Nuno A. Fonseca; Isidro Cortés-Ciriano; Qian Xiang; Brian Craft; Elena Piñeiro-Yáñez; Brian D. O’Connor; Wojciech Bazant; Elisabet Barrera; Alfonso Muñoz-Pomer; Robert Petryszak; Anja Füllgrabe; Fatima Al-Shahrour; Maria Keays; David Haussler; John N. Weinstein; Wolfgang Huber; Alfonso Valencia; Peter J. Park; Irene Papatheodorou; Jingchun Zhu; Vincent Ferretti; Miguel

    The Pan-Cancer Analysis of Whole Genomes (PCAWG) project generated a vast amount of whole-genome cancer sequencing resource data. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2658 cancers across 38 tumor types, we provide a user’s guide to the five publicly available online data exploration and visualization

    更新日期:2020-07-07
  • Enhancer and super-enhancer dynamics in repair after ischemic acute kidney injury
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-07
    Julia Wilflingseder; Michaela Willi; Hye Kyung Lee; Hannes Olauson; Jakub Jankowski; Takaharu Ichimura; Reinhold Erben; M. Todd Valerius; Lothar Hennighausen; Joseph V. Bonventre

    The endogenous repair process can result in recovery after acute kidney injury (AKI) with adaptive proliferation of tubular epithelial cells, but repair can also lead to fibrosis and progressive kidney disease. There is currently limited knowledge about transcriptional regulators regulating these repair programs. Herein we establish the enhancer and super-enhancer landscape after AKI by ChIP-seq in

    更新日期:2020-07-07
  • Methylmercury produced in upper oceans accumulates in deep Mariana Trench fauna
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-07
    Ruoyu Sun; Jingjing Yuan; Jeroen E. Sonke; Yanxu Zhang; Tong Zhang; Wang Zheng; Shun Chen; Mei Meng; Jiubin Chen; Yi Liu; Xiaotong Peng; Congqiang Liu

    Monomethylmercury (MMHg) is a potent toxin that bioaccumulates and magnifies in marine food webs. Recent studies show abundant methylated Hg in deep oceans (>1000 m), yet its origin remains uncertain. Here we measured Hg isotope compositions in fauna and surface sediments from the Mariana Trench. The trench fauna at 7000–11000 m depth all have substantially positive mass-independent fractionation of

    更新日期:2020-07-07
  • Structure of the yeast Swi/Snf complex in a nucleosome free state
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-07
    Chengcheng Wang; Zhouyan Guo; Xiechao Zhan; Fenghua Yang; Mingxuan Wu; Xiaofeng Zhang

    SWI/SNF remodelers play a key role in regulating chromatin architecture and gene expression. Here, we report the cryo-EM structure of the Saccharomyces cerevisiae Swi/Snf complex in a nucleosome-free state. The structure consists of a stable triangular base module and a flexible Arp module. The conserved subunits Swi1 and Swi3 form the backbone of the complex and closely interact with other components

    更新日期:2020-07-07
  • Wnt-controlled sphingolipids modulate Anthrax Toxin Receptor palmitoylation to regulate oriented mitosis in zebrafish
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-03
    I. Castanon; J. T. Hannich; L. Abrami; F. Huber; M. Dubois; M. Müller; F. G. van der Goot; M. Gonzalez-Gaitan

    Oriented cell division is a fundamental mechanism to control asymmetric stem cell division, neural tube elongation and body axis extension, among other processes. During zebrafish gastrulation, when the body axis extends, dorsal epiblast cells display divisions that are robustly oriented along the animal-vegetal embryonic axis. Here, we use a combination of lipidomics, metabolic tracer analysis and

    更新日期:2020-07-07
  • The induction and function of the anti-inflammatory fate of T H 17 cells
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-03
    Hao Xu; Theodora Agalioti; Jun Zhao; Babett Steglich; Ramez Wahib; Maria Carolina Amezcua Vesely; Piotr Bielecki; Will Bailis; Ruaidhri Jackson; Daniel Perez; Jakob Izbicki; Paula Licona-Limón; Vesa Kaartinen; Jens Geginat; Enric Esplugues; Eva Tolosa; Samuel Huber; Richard A. Flavell; Nicola Gagliani

    TH17 cells exemplify environmental immune adaptation: they can acquire both a pathogenic and an anti-inflammatory fate. However, it is not known whether the anti-inflammatory fate is merely a vestigial trait, or whether it serves to preserve the integrity of the host tissues. Here we show that the capacity of TH17 cells to acquire an anti-inflammatory fate is necessary to sustain immunological tolerance

    更新日期:2020-07-07
  • Author Correction: Epstein–Barr virus-encoded microRNA BART1 induces tumour metastasis by regulating PTEN-dependent pathways in nasopharyngeal carcinoma
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-06
    Longmei Cai; Yanfen Ye; Qiang Jiang; Yuxiang Chen; Xiaoming Lyu; Jinbang Li; Shuang Wang; Tengfei Liu; Hongbing Cai; Kaitai Yao; Ji-Liang Li; Xin Li

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

    更新日期:2020-07-06
  • Publisher Correction: A quantitative sequencing framework for absolute abundance measurements of mucosal and lumenal microbial communities
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-06
    Jacob T. Barlow; Said R. Bogatyrev; Rustem F. Ismagilov

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

    更新日期:2020-07-06
  • Author Correction: Naturally-occurring cholesterol analogues in lipid nanoparticles induce polymorphic shape and enhance intracellular delivery of mRNA
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-06
    Siddharth Patel; N. Ashwanikumar; Ema Robinson; Yan Xia; Cosmin Mihai; Joseph P. Griffith; Shangguo Hou; Adam A. Esposito; Tatiana Ketova; Kevin Welsher; John L. Joyal; Örn Almarsson; Gaurav Sahay

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

    更新日期:2020-07-06
  • Author Correction: Brainstem and spinal cord MRI identifies altered sensorimotor pathways post-stroke
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-06
    Haleh Karbasforoushan; Julien Cohen-Adad; Julius P. A. Dewald

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

    更新日期:2020-07-06
  • A flat carborane with multiple aromaticity beyond Wade–Mingos’ rules
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-06
    Wei Lu; Dinh Cao Huan Do; Rei Kinjo

    It is widely known that the skeletal structure of clusters reflects the number of skeletal bonding electron pairs involved, which is called the polyhedral skeletal electron pair theory (PSEPT) or Wade and Mingos rules. While recent computational studies propose that the increase of skeletal electrons of polyhedral clusters leads to the flat structure beyond the PSEPT, little experimental evidence has

    更新日期:2020-07-06
  • An evaluation of COVID-19 serological assays informs future diagnostics and exposure assessment
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-06
    Corine H. GeurtsvanKessel; Nisreen M. A. Okba; Zsofia Igloi; Susanne Bogers; Carmen W. E. Embregts; Brigitta M. Laksono; Lonneke Leijten; Casper Rokx; Bart Rijnders; Janette Rahamat-Langendoen; Johannes P. C. van den Akker; Jeroen J. A. van Kampen; Annemiek A. van der Eijk; Rob S. van Binnendijk; Bart Haagmans; Marion Koopmans

    The world is entering a new era of the COVID-19 pandemic in which there is an increasing call for reliable antibody testing. To support decision making on the deployment of serology for either population screening or diagnostics, we present a detailed comparison of serological COVID-19 assays. We show that among the selected assays there is a wide diversity in assay performance in different scenarios

    更新日期:2020-07-06
  • Genomic basis of homoploid hybrid speciation within chestnut trees
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-06
    Yongshuai Sun; Zhiqiang Lu; Xingfu Zhu; Hui Ma

    Hybridization can drive speciation. We examine the hypothesis that Castanea henryi var. omeiensis is an evolutionary lineage that originated from hybridization between two near-sympatric diploid taxa, C. henryi var. henryi and C. mollissima. We produce a high-quality genome assembly for mollissima and characterize evolutionary relationships among related chestnut taxa. Our results show that C. henryi

    更新日期:2020-07-06
  • Contactless probing of polycrystalline methane hydrate at pore scale suggests weaker tensile properties than thought
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-06
    Dyhia Atig; Daniel Broseta; Jean-Michel Pereira; Ross Brown

    Methane hydrate is widely distributed in the pores of marine sediments or permafrost soils, contributing to their mechanical properties. Yet the tensile properties of the hydrate at pore scales remain almost completely unknown, notably the influence of grain size on its own cohesion. Here we grow thin films of the hydrate in glass capillaries. Using a novel, contactless thermal method to apply stress

    更新日期:2020-07-06
  • Astrocytic Ca 2+ signaling is reduced during sleep and is involved in the regulation of slow wave sleep
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-06
    Laura Bojarskaite; Daniel M. Bjørnstad; Klas H. Pettersen; Céline Cunen; Gudmund Horn Hermansen; Knut Sindre Åbjørsbråten; Anna R. Chambers; Rolf Sprengel; Koen Vervaeke; Wannan Tang; Rune Enger; Erlend A. Nagelhus

    Astrocytic Ca2+ signaling has been intensively studied in health and disease but has not been quantified during natural sleep. Here, we employ an activity-based algorithm to assess astrocytic Ca2+ signals in the neocortex of awake and naturally sleeping mice while monitoring neuronal Ca2+ activity, brain rhythms and behavior. We show that astrocytic Ca2+ signals exhibit distinct features across the

    更新日期:2020-07-06
  • Uncovering mutation-specific morphogenic phenotypes and paracrine-mediated vessel dysfunction in a biomimetic vascularized mammary duct platform
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-06
    Matthew L. Kutys; William J. Polacheck; Michaela K. Welch; Keith A. Gagnon; Thijs Koorman; Sudong Kim; Linqing Li; Andrea I. McClatchey; Christopher S. Chen

    The mammary gland is a highly vascularized tissue capable of expansion and regression during development and disease. To enable mechanistic insight into the coordinated morphogenic crosstalk between the epithelium and vasculature, we introduce a 3D microfluidic platform that juxtaposes a human mammary duct in proximity to a perfused endothelial vessel. Both compartments recapitulate stable architectural

    更新日期:2020-07-06
  • Two-dimensional optomechanical crystal cavity with high quantum cooperativity
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-06
    Hengjiang Ren; Matthew H. Matheny; Gregory S. MacCabe; Jie Luo; Hannes Pfeifer; Mohammad Mirhosseini; Oskar Painter

    Optomechanical systems offer new opportunities in quantum information processing and quantum sensing. Many solid-state quantum devices operate at millikelvin temperatures—however, it has proven challenging to operate nanoscale optomechanical devices at these ultralow temperatures due to their limited thermal conductance and parasitic optical absorption. Here, we present a two-dimensional optomechanical

    更新日期:2020-07-06
  • Ultrathin-metal-film-based transparent electrodes with relative transmittance surpassing 100%
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-06
    Chengang Ji; Dong Liu; Cheng Zhang; L. Jay Guo

    Flexible transparent electrodes are in significant demand in applications including solar cells, light-emitting diodes, and touch panels. The combination of high optical transparency and high electrical conductivity, however, sets a stringent requirement on electrodes based on metallic materials. To obtain practical sheet resistances, the visible transmittance of the electrodes in previous studies

    更新日期:2020-07-06
  • Rapid geomagnetic changes inferred from Earth observations and numerical simulations
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-06
    Christopher J. Davies; Catherine G. Constable

    Extreme variations in the direction of Earth’s magnetic field contain important information regarding the operation of the geodynamo. Paleomagnetic studies have reported rapid directional changes reaching 1° yr−1, although the observations are controversial and their relation to physical processes in Earth’s core unknown. Here we show excellent agreement between amplitudes and latitude ranges of extreme

    更新日期:2020-07-06
  • Proton-transfer-induced 3D/2D hybrid perovskites suppress ion migration and reduce luminance overshoot
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-06
    Hobeom Kim; Joo Sung Kim; Jung-Min Heo; Mingyuan Pei; In-Hyeok Park; Zhun Liu; Hyung Joong Yun; Min-Ho Park; Su-Hun Jeong; Young-Hoon Kim; Jin-Woo Park; Emad Oveisi; Satyawan Nagane; Aditya Sadhanala; Lijun Zhang; Jin Jung Kweon; Sung Keun Lee; Hoichang Yang; Hyun Myung Jang; Richard H. Friend; Kian Ping Loh; Mohammad Khaja Nazeeruddin; Nam-Gyu Park; Tae-Woo Lee

    Perovskite light-emitting diodes (PeLEDs) based on three-dimensional (3D) polycrystalline perovskites suffer from ion migration, which causes overshoot of luminance over time during operation and reduces its operational lifetime. Here, we demonstrate 3D/2D hybrid PeLEDs with extremely reduced luminance overshoot and 21 times longer operational lifetime than 3D PeLEDs. The luminance overshoot ratio

    更新日期:2020-07-06
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