The capacity to efficiently deliver the gene-editing enzyme complex to target cells is favored over other forms of gene delivery as it offers one-time hit-and-run gene editing, thus improving precision and safety and reducing potential immunogenicity against edited cells in clinical applications. Here we performed a proof-of-mechanism study and demonstrated that a simian adenoviral vector for DNA delivery

Nanozymes exhibiting antioxidant activity are beneficial for the treatment of oxidative stress-associated diseases. Ruthenium nanoparticles (RuNPs) with multiple enzyme-like activities have attracted growing attention, but the relatively low antioxidant enzyme-like activities hinder their practical biomedical applications. Here, a size regulation strategy is presented to significantly boost the antioxidant

Nanovaccine-based immunotherapy (NBI) has the ability to initiate dendritic cell (DC)-mediated tumor-specific immune responses and maintain long-term antitumor immune memory. To date, the mechanism by which the mechanical properties of nanoparticles alter the functions of DCs in NBI remains largely unclear. Here, a soft mesoporous organosilica-based nanovaccine (SMONV) is prepared and the elasticity-dependent

Cancer Immunotherapy

Small 2020, 16, 1900550 DOI: 10.1002/smll.201900550 In the originally published article, there was a typo in the first funding number for the Tianjin Municipal Science and Technology Commission (18TCQNJC71500). The correct number is 18JCQNJC71500. The authors apologize for any confusion this may have caused.

Small 2022, 18, 2200395 DOI: 10.1002/smll.202200395 In the originally published article, the name of the fourth author was incorrect. “Yin-Rui Lu” should have been written as “Ying-Rui Lu.” The byline is corrected here. The authors apologize for any confusion this may have caused.

The major difficulties for the development of flexible energy storage batteries lie in the scalable manufacture of high-performance flexible electrodes with bending tolerance. In the present study, large-scale CNT films are prepared by a continuous production method and used to fabricate a self-supported flexible high-capacity conversion anode with ultra-long cycling life by in-situ growth of NiCo2S4

Stimulus-responsive ternary chalcogenide nanomaterials are regarded as promising ‘all-in-one’ nanotheranostics agents, on account of their tunable band structures and multi-metal intrinsic properties. Herein, ultrasmall AgBiSe2 nanodots are prepared by a simple thermal injection method. It shows a narrow band gap of 0.91 eV and high absorption coefficient in the NIR-II biowindow, resulting in excellent

This work is devoted to the theoretical study of the structural and magnetic properties of an ensemble of single-domain interacting magnetic nanoparticles immobilized in a non-magnetic medium. This model is typical for describing magnetically active soft materials -- "smart" polymer ferrocomposites, which have been applied in science-intensive industrial and biomedical technologies. It is assumed that

Fullerene-derived carbons have been demonstrated as effective electrode materials for electrocatalytic reactions. The heteroatoms in the carbon matrix are essential to enhance their electrocatalytic performance but are still challenging for effective doping strategies and understanding their synergistic effect. Herein, we regulate the phosphorous/nitrogen (P/N) doping in carbon structure based on the

Powdery N-doped carbon-supported single-atom catalysts (SACs) can be prepared at a large scale and are highly selective for coverting CO2 to CO, but their practical application is restricted by their powdery status. Herein, we report Ni single atoms supported on hierarchically porous N-doped carbonized wood (Ni SAs-NCW) as a self-supported electrode for efficient and durable CO2 electroreduction. The

Nanoparticle flexibility is an important parameter in determining cell uptake and tumor accumulation, thus modulating therapeutic efficiency in cancer treatment. Herein, we successfully prepared CuS-embedded hollow human serum albumin nanocapsules (denoted CuS/HSA) by a hard-core-assisted layer-by-layer coating approach. This approach afforded CuS/HSA hollow nanocapsules with controllable shell thickness

Nitric oxide (NO) has many important biological functions; however, it has been a long-standing challenge to utilize the exogenous NO donor itself in the activation of macrophages for cancer immunotherapy. Herein, we report the synthesis of a nanoparticle-based NO delivery platform with a rational design for effective NO delivery and macrophage activation. S-Nitrosothiol (SNO) modified organosilica

Coronavirus disease (COVID-19) has affected people for over two years. Moreover, the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants has raised concerns regarding its accurate diagnosis. Here, we report a colorimetric DNAzyme reaction triggered by loop-mediated isothermal amplification (LAMP) with clustered regularly interspaced short palindromic repeats (CRISPR)

Fabricating lateral heterostructures (HSs) and superlattices (SLs) provides unique degree of freedom for modulating physical properties of two-dimensional (2D) materials by varying chemical component, geometric size and interface structure in the ultra-thin atomic thickness limit. While a variety of 2D lateral HSs/SLs have been synthesized, especially for transition metal dichalcogenides (TMD), how

Crystal phase is a key factor to determine the physical and chemical properties of crystalline materials. As a new class of nanoscale structures, heterophase nanoparticles, which assemble conventional and unconventional phases, present exceptional properties in comparison with their single-phase counterparts. In this work, we explored the thermodynamical stability of Au, Co, and AuCo heterophase nanoparticles

As a potential oxygen evolution reaction (OER) catalyst, Co-based perovskites have received intensive attentions. However, Sr is readily to accumulate on their surface, then makes them inert toward OER. Herein, we propose a simple but versatile electrochemical reduction method to reconstruct the active surface of Co-based perovskites within a few seconds. By this method, Sr rapidly precipitates from

The acquisition of monodispersed metal nanoparticles covered by conductive metal-organic frameworks (cMOFs) is an archetype of the electrons-unobstructed core-shell composite, valued for its potential electrocatalytic ability and selectivity enhancement. In this work, Pt@cMOFs composites with direct interfaces showed better performance in oxygen reduction reaction than composites with indirect interfaces

Rechargeable aluminum-ion batteries, RAIBs, as a prime candidate for next-generation batteries, have attracted much attention due to the extremely high anode capacity and good safety. However, the lack of matching high-capacity cathode materials and reasonable design limit their practical development. Herein, core-shelled Sb@C nanorods is prepared by polymer coating and thermal reduction as metal-based

The development of intrinsically safe and environmentally sustainable energy storage devices is a significant challenge. Recent advances in aqueous rechargeable lithium-ion batteries (ARLIBs) have made considerable steps in this direction. In parallel to the ongoing progress in the design of aqueous electrolytes that expand the electrochemically-stable potential window, the design of negative electrode

To detect the heavy metal toxicity by using self-assembled nanostructures a clathrin triskelion inspired highly functional C3-symmetric trimerized biotinylated di-tryptophan peptide was used. This triskelion peptide is known to be self-assembled into nanotorus-like structures and therefore can act as nanocages for various analytes. In this work, in addition to spectroscopy, interestingly force and

Over the years, there have been major advances in two-dimensional (2D) materials on account of their excellent and unique properties. Among the various strategies for 2D materials fabrication, chemical vapor deposition (CVD) is considered as the most promising method to fulfill large-area and high-quality 2D film growth. Furthermore, to realize the potential applications of 2D materials in different

Electrostatic discharge is a fatal threat to a variety of electronic products. Here we report on a polymer nanocomposite composed of a dielectric polymer embedded with aligned core–shell structured nanowires for highly efficient distributed electrostatic discharge protection. The dielectric nanocomposite is capable of self-adaptive charge release, stemming from the nonlinear interface built in the

Spots with dual structural colors on the skin of some organisms in nature are of tremendous interest due to the unique function of their dye-free colors. However, imitation of them requires complicated manufacturing processes, expensive equipment, and multiple predesigned building blocks. In this work, a one-pot strategy based on the phase-separation-assisted nonuniform self-assembly of monosized silica

Laser-induced graphene (LIG) suffers from serious decay in long-term biosensing, which greatly restricts its practical applications. Herein, we report a new strategy to engineer the LIG surface with Au clusters and chitosan sequentially to form a C–Au–LIG electrode with a superhydrophilic and highly conductive 3D graphene surface, which demonstrates superior performance and negligible decay in both

Activating metamagnetic transitions between ordered states in van der Waals magnets and devices bring great opportunities in spintronics. We show that external pressure, which enhances the interlayer hopping without introducing chemical disorders, triggers multiple metamagnetic transitions upon cooling in the topological van der Waals magnets Mn(Bi1–xSbx)4Te7, where the antiferromagnetic interlayer

The physics of dynamic friction on water molecule contaminated surfaces is still poorly understood. In line with the growing interest in hydrophobic contact for industrial applications, this paper focuses on friction mechanisms in such interfaces. As a commonly used material, contact with graphite is considered in a twin-fold approach based on experimental investigations using the circular mode atomic

Individual single-walled carbon nanotubes with covalent sidewall defects have emerged as a class of photon sources whose photoluminescence spectra can be tailored by the carbon nanotube chirality and the attached functional group/molecule. Here we present electroluminescence spectroscopy data from single-tube devices based on (7, 5) carbon nanotubes, functionalized with dichlorobenzene molecules, and

Advanced peptide-based nanomaterials composed of self-assembling peptides (SAPs) are of emerging interest in pharmaceutical and biomedical applications. The introduction of fluorine into peptides, in fact, offers unique opportunities to tune their biophysical properties and intermolecular interactions. In particular, the degree of fluorination plays a crucial role in peptide engineering as it can be