This study presents the design of biotin-functionalized hybrid polyionic complexes (HPICs) using RAFT polymers for targeted MRI applications. The synthesized colloidal vectors, complexed with gadolinium ions, demonstrate high stability, relaxivity, and biotin accessibility for active targeting. Preliminary in vivo studies confirm their potential for improved MRI contrast and pharmacokinetic tracking

Polyethylene glycol (PEG) is a commonly used coating agent in nanomedicine, but there are growing concerns about its immunogenicity. Two Comment articles discuss the issue and possible alternatives to PEG.

Inflammatory bowel disease (IBD) is characterized by an overproduction of reactive oxygen species (ROS) and an imbalance in macrophage activity, highlighting the need for innovative treatments that combine anti-inflammatory efficacy with strong clinical potential. We developed ultrasmall Prussian blue nanodots (UPBs) utilizing a novel solvation effect preparation method, achieving quantum dots with

High-pressure (HP) effect on surface-enhanced Raman spectroscopy (SERS) is a new-horizon due to the importance of pressure, an external stimulus that can tune the lattice and electronic band structure of the SERS substrate and the analyte molecule. Here, we have used ZIF-67 as the pressure induced (PI)-SERS substrate and R6G molecules as analyte to explore the SERS effect in both the compression and

DS@CeO₂@R837 nanozymes with superoxide dismutase-, catalase-, and peroxidase-like activities effectively reshape the tumor microenvironment, combining microwave thermotherapy and immunotherapy for breast cancer treatment.