Non-invasive tracking of stem cells after transplant is necessary for cell therapy and tissue engineering field. Herein, we introduce natural and biodegradable nanoparticle to develop a highly efficient nanoprobe with the ability to penetrate the stem cell for tracking. Based on the use of (Gd3+) to label stem cells for magnetic resonance imaging (MRI) we synthesized nanoparticle-containing Gd3+. Gd3+

Lung diseases are common health problems in many countries. The dysfunction of bronchial epithelial cells is important for the development of lung diseases. Recent progress reveals that inflammasome is the fundamental mechanism of epithelial activation. Here, we report the protective effect of doxofylline, a theophylline derivative agent, on lipopolysaccharides (LPS)-induced inflammatory response in

Background: Involvements of microRNA-22 (miR-22) in cancer have attracted much attention, but its role in diagnosis of hepatocellular carcinoma (HCC) is still largely unknown. Therefore, the aim of this study was to investigate the expression level and the prognostic value of miR-22 in HCC patients.Methods: Quantitative real-time polymerase chain reaction (qRT-PCR) was performed to evaluate serum level

The present study highlights the biological synthesis of silver nanoparticles (AgNPs) using Sphingobium sp. MAH-11 and also their antibacterial mechanisms against drug-resistant pathogenic microorganisms. The nanoparticle synthesis method used in this study was reliable, facile, rapid, cost-effective and ecofriendly. The AgNPs exhibited the highest absorbance at 423 nm. The TEM image expressed spherical

Aim: To analyze the impact of CD32a polymorphism rs1801274 on the occurrence of Kawasaki disease (KD) through the meta-analysis.Methods: The correlation between CD32a polymorphism rs1801274 and the susceptibility to KD was appraised using summarized odds ratios (ORs) with their 95% confidence intervals (95% CIs). Besides, stratification analyses were further implemented on the basis of ethnicity and

91H, a long non-coding antisense transcripts located on the position of the H19/IGF2 locus had been suggested to play a critical role in tumour development. However, little study had proved the mechanism in colorectal cancer (CRC). Hence, we performed this study to deeply explore the mechanism of lncRNA 91H in tumour progression. The expression of lncRNA 91H was first detected in CRC tissues and cells

Smoking is an important factor in the pathogenesis of chronic obstructive pulmonary disease (COPD), which is commonly characterised by cellular senescence and inflammation. Recently, miR-200b has emerged as an important target to cure lung disease; however, the function of miR-200b in reducing cellular senescence and inflammatory responses has not been reported. In this study, we found that miR-200b

Recently, the functions of circular RNAs (circRNAs) on cancer initiation and development arouse wide concern. Herein, we tested the influences of circ-ZNF652 on renal carcinoma cell growth and metastasis. Firstly, clinical renal carcinoma tissues and corresponding normal tissues were collected. The circ-ZNF652 expressions were tested. Then, the influences of silencing circ-ZNF652 on renal carcinoma

Background: Protocatechuic aldehyde (PA) extracts from S. miltiorrhiza, which anti-oxidative and anti-inflammatory functions have been certified in diverse diseases. Nonetheless, the influence of PA in spinal cord injury (SCI) is still hazy. The research probed the function of PA in hydrogen peroxide (H2O2)-damaged PC12 cells.Methods: The disparate dosages of H2O2 (0-400 µM) or PA (0-2 µM) were applied

Paclitaxel (PTX), a tubulin-binding agent, is widely used and has shown good efficacy in the initial period of treatment for non-small cell lung cancer (NSCLC). However, the relatively rapid acquisition of resistance to PTX treatments that is observed in virtually all cases significantly limits its utility and remains a substantial challenge to the clinical management of NSCLC. The aim of this study

Celastrol is used in traditional Chinese medicine for treating cancers. However, its low water solubility and poor tumour selection represent major pitfalls for clinical application. In the present study, gold nanoparticle (AuNP) firstly was conjugated with PVP-co-2-dimethylaminoethyl methacrylate (Polymer) and celastrol then modified by folic acid. The as-prepared folate receptor-targeted celastrol

Gastric cancer (GC) is a malignant tumour with high lethality. Accruing evidence elucidates the critical adjusting role of long non-coding RNA (lncRNAs) in human cancers. DDX11 antisense RNA 1 (DDX11-AS1) was previously found to be involved in GC pathogenesis. However, the precise molecular mechanisms of DDX11-AS1 need to be further investigated. In this study, we found that DDX11-AS1 expression was

We aimed to evaluate the therapeutic effects of exosomes, which were collected from human neuroepithelial stem cells (HNESCs) treated by miR-29b mimics, on the treatment of spinal cord injury (SCI). Computational analysis, real-time PCR, Western blot analysis and TUNEL assay, a BBB score system, the Nissl staining and IHC assay were conducted to explore the molecular signalling pathway underlying the

Hsa_circ_0058124 was reported to possess the capacity of enhancing tumorigenesis and invasiveness. This investigation explored the effects of hsa_circ_0058124 on human lung cancer. qRT-PCR was employed for assessing the expression of hsa_circ_0058124 and miR-1297. Cell transfection was conducted for altering the expression of hsa_circ_0058124 and miR-1297. Dual-luciferase reporter gene assay was employed

Background: Hypoxic-ischaemic encephalopathy (HIE) is a prevailing severe brain damage disease in newborns, and caused by perinatal asphyxia cerebral ischaemia and reperfusion. Here, we investigated the role of cZNF292 in oxygen-glucose deprivation/reperfusion (OGD/R)-induced neural stem cells (NSCs) injury, and explored the underlying molecular mechanism.Methods: Before NSCs were subjected to OGD/R

Increasing number of literatures highlighted lncRNA maternally expressed gene 3 (MEG3) as an emerging target for hypoxic-ischaemic brain damage (HIBD). This study attempted to assess the role of MEG3 in a cell model of HIBD. Expression of MEG3 in PC12 cells was suppressed by siRNA-mediated transfection, after which the cells were subjected to hypoxia. Cell viability, apoptosis, migration and the expression

Vulvar intraepithelial neoplasia (VIN) is associated with human papillomavirus (HPV) infection. Curcumin is a natural bioactive compound with antineoplastic properties. The use of nanoparticles containing curcumin could allow a better performance of this compound in therapies. So, VIN biopsies were collected and HPV DNA detection was performed by PCR, positive samples were genotyped by Restriction

In this paper, the first bio-nano colloid including manganese oxide nanoparticles and copper nanocomplex in the presence of Amaranthus spinosus as one unwanted plant was prepared (Mn3O4/CuL bio-nanocolloid). As-prepared bio nanocolloid was analysed completely by different techniques such as FT-IR, ICP-AES, SEM, EDX, TEM and elemental analysis to have the size, structure, morphology and elements in

Hypoxia is an important cause of myocardial cell loss, further inducing various heart illnesses, including acute myocardial infraction (AMI). Long non-coding RNA (LncRNA) discrimination antagonising non-protein coding RNA (DANCR) was firstly identified as epidermal cell differentiation suppressor. Here, we aimed to explore the effects and mechanism of DNACR in hypoxia-induced H9c2 cells. Hypoxic cells

Here we presented a novel micelle self-assembled from amphiphiles with π-conjugated moieties (OEG-DPH). The π-conjugated structural integrity of the micelles enabled stable encapsulation of Nile Red (NR, model drug). The self-assembly behaviour of the amphiphiles and the release profile of NR loaded micelles were investigated. Spherical core-shell structured NR loaded micelles with low CMC of 57 μg/mL

Superparamagnetic iron oxide nanoparticles (SPIONs) have been employed in several biomedical applications where they facilitate both diagnostic and therapeutic aims. Although the potential benefits of SPIONs with different surface chemistry and conjugated targeting ligands/proteins are considerable, complicated interactions between these nanoparticles (NPs) and cells leading to toxic impacts could

Background: Although dexmedetomidine (Dex) has a significant neuroprotective effect in various nerve-damage models, the exact mechanism of which Dex protects cells from oxidative damage is not fully clear. This article recommended the protective effect of Dex on oxidative damage in PC12 cells.Methods: The PC12 cells were incubated by hydrogen peroxide (H2O2) for 24 h and pre-treated by Dex for 30 min

Human hepatocellular carcinoma (HCC) is the most common type of liver cancer, and it has a high mortality rate. Despite surgical treatments, radiotherapy, and chemotherapy, the median survival of patients with advanced HCC is low. Evidence has shown that tanshinone (TA) I exhibits anti-proliferative activity against numerous cancers. However, the role of TA I and its mechanism in HCC remain unknown

Background: Infantile pneumonia (IP) seriously affects the health of children. This article mainly discussed the protective effect of long non-coding RNA NKILA (lnc NKILA) on IP by detecting cell viability, apoptosis and inflammatory response of MRC5 cells.Methods: Cell counting kit-8 (CCK-8) was used to detect cell viability, while flow cytometry was used to detect cell apoptosis. The expression of

Cervical cancer is the second most common malignant tumour threatening women's health. In recent years, heavy-ion beam therapy is becoming a newly emerging therapeutic mean of cancer; however, radio-resistance and radiation-induced damage constitute the main obstacles for curative treatment of cervical cancer. Therefore, to identify the radiosensitizers is essential. Here, we investigated the effects

Schisandrin B (Sch B) and miR-101 family members play critical roles in the pathogenesis of liver fibrosis. However, the relationship between them has not been reported yet. Thus, this study aims to fill this research gap. Results showed that Sch B significantly upregulated the expression of miR-101-5p in HSC-T6 cells. Sch B also increased the expression of miR-101-5p by combined administration of

Diabetic retinopathy (DR) is the leading cause of decreased vision and blindness globally. The aim of this study was to understand the role of physcion 8-O-β-glucopyranoside (PG) in high glucose (HG)-induced DR and to investigate whether lncRNA NORAD/miR-125/STAT3 signalling was the underlying mechanism involved in DR. To this end, the serum levels of NORAD, miR-125, and STAT3 were determined in patients

Clostridium difficile (C. difficile) infection results in toxin-induced epithelial injury and marked colonic inflammation. Mitogen-activated protein kinase (MAPK) and NF-κB which regulated by MAP kinase phosphatase (MKP, also known as dual specificity phosphatases, DUSP) are fundamental signalling pathways that mediate multiple cellular processes. However, the regulation of DUSP/MAPKs and NF-κB pathway

Non-coding RNAs play an important role in the pathogenesis of prostate cancer (PC). This study aims to characterize the role of GAS5 rs145204276 and HOTAIR rs4759314 polymorphisms in the pathogenesis of PC. Both INS allele of GAS5 rs145204276 and A allele of HOTAIR rs4759314 were identified to increase the survival of PC patients. And patients carrying DEL/DEL + AG genotypes tend to present higher

Abdominal wall defects are associated with abdominal wall surgery, infection and tumour resection. Polypropylene (PP) mesh, which has excellent mechanical strength, is currently the primary clinical repair material. In repairing the abdominal wall, the mesh can erode the bowel and cause other problems. Constructing a barrier that induces a weak inflammatory response and promotes rapid recovery of the

Objective: To investigate the effects of microRNA-142-3p (miR-142-3p) on the biological characteristics of pancreatic cancer cells and its mechanism.Methods: The expression of miR-142-3p and nuclear casein kinase and cyclin-dependent kinase substrate 1 (NUCKS1) in pancreatic tissues and four cancer cell lines (Panc-1, BxPC-3, AsPC-1, MIA-PaCa2) were detected by Quantitative PCR (qPCR) or Western blot

Overexpression of CD30 has been reported on the surface of some T-cell lymphomas, especially on Hodgkin's lymphoma (HL) and anaplastic large cell lymphoma (ALCL). CD30 targeted immunotherapy has good clinical therapy response. We have produced a novel antibody drug conjugates (ADCs)-anti-CD30-LDM, which shows attractive tumour-targeting capability and extremely potent antitumor efficacy. To further

LncRNA PTENP1 is a competitive endogenous RNA (ceRNA) involved in decoying miR-106b in multiple diseases. This study investigates the interaction of PTENP1 and miR-106b in cell proliferation, apoptosis and epithelial-mesenchymal transition (EMT) in cervical cancer. The expressions of PTENP1, miR-106b and PTEN were determined in cervical cancer tissues, adjacent normal tissues, cervical cancer cells

Amphiphilic block copolymers used as nanomicelle drug carriers can effectively overcome poor drug solubility and specificity issues. Hence, these platforms have a broad applicability in cancer treatment. In this study, Pluronic F127 was used to fabricate nanomicelles containing the histone deacetylase inhibitor SAHA, which has an epigenetic-driven anti-cancer effect in several tumor types. SAHA-loaded

Breast cancer is therapeutically very challenging to treat as it has the main four known genetic alterations, which result in the existence of several phenotypes leading to the difference in the mode of therapy and with poor outcome. Metallic nanoparticles of silver or copper have been studied previously as anticancer agents in breast cancer and other types of cancers. However, the anticancer effect

Cobalt ferrite nanoparticles were exposed to mechanochemical activation, with and without equimolar amounts of graphene nanoparticles, for time periods ranging from 0 to 12 hours. Their structural and magnetic properties were detailed from Mӧssbauer spectroscopy and magnetic measurements. The Mӧssbauer spectrum corresponding to the unmilled cobalt ferrite powder was analyzed using 2 sextets, corresponding

In this study, BiOI was successfully synthesized using a hydrothermal method and then modified using hexamethyldisiloxane (HMDS) and polydimethylsiloxane (PDMS), respectively, to achieve a controllable water contact angle (WCA) for these materials. The physical and chemical properties of the modified BiOI were characterized using X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), scanning

Double element co-doped carbon quantum dots (CQDs) have unique electron properties and broad prospects in photocatalysis. In this paper, the phosphorus and nitrogen co-doped CQDs (PNCQDs) were loaded on TiO2 nanosheets by in-situ synthesis method. Physical structure and chemical composition of samples were analyzed by XRD, FT-IR, XPS, SEM and TEM. UV–Vis spectra show the donor–acceptor coupling between

The sodium ion pre-intercalation manganese dioxide (NaxMnO2) is supported on titanium nitride (TiN) substrate to form electroactive NaxMnO2/TiN electrode through an electrodeposition process in Mn(CH3COOH)2/Na2SO4 precursors with high Mn/Na ratio. MnO2 has a tiled leaf-like structure with a wrinkling morphology. NaxMnO2 has a cross-linking nanorod structure with a nanoporous morphology, which is beneficial

In this work, a sensor for quantitative detection of uric acid (UA) is successfully prepared by electrodepositing Nickel–Copper (Ni–Cu) alloy nanoparticles on poly (3,4-ethyldioxythiophene) modified nitrogen-containing grapheme (Ni–Cu/PEDOT/NGE). The anchoring of PEDOT and Cu–Ni alloy nanoparticles on NGE not only prevents the agglomeration of NGE, but also improves the catalytic activity of the composites

Prostate cancer is a leading health burden, the third most common cancer in a man. High accuracy detection and screening methods with a suitable biomarker can significantly reduce the risk of mortality. Prostate specific antigen (PSA) is the efficient and acceptable biomarker due to its level of increment in the biological fluid with the prostate cancer patient. This research was focused to establish

A new type of multifunctional metal-organic frameworks (MOFs) was synthesized by encapsulating gold nanoparticles (AuNPs) into the Cu-hemin MOFs, and first applied to an electrochemical sensor to detect catechol (CT) with the aid of electrochemically reduced graphene oxide (ERGO) for signal amplification. First, ERGO was electrochemically deposited on a bare glass carbon electrode (GCE), followed by

Microencapsulated phase change materials (MicroPCM) were prepared via sol–gel method using paraffin as heat storage core and silica as inorganic shell. The morphology feature, chemical structure, thermal properties and thermal stability of MicroPCM were characterized by the field emission scanning electron microscope (FE-SEM), Fourier transform infrared spectroscopy (FTIR), the differential scanning

Spinel structure NiCo2O4 suffers from poor electric conductivity and the resulted electrochemical properties in battery/supercapacitor system are still unsatisfied. In this paper, a free-standing electrode based on in-situ growth NiCo2O4 on carbon cloth has been synthesized by a surfactant-assisted solvothermal method (sodium dodecyl sulfate, SDS). The functional carbon cloth substrate makes unexpected

In this paper, three kinds of SnO2 precursors were comparatively investigated for low temperature solution-processed SnO2 films as electron transport layers (ETL) of CsPbBr3 perovskite solar cells (PSCs). It was found that the precursor state and solvent type played an important role on the crystallinity and film-forming performance of SnO2. All-inorganic hole-transport-layer-free planar CsPbBr3 PSCs

Melanoma, one of the most malignant tumors, is difficult to treat due to its high drug resistance. Silver nanoparticles (AgNPs) are widely used as antimicrobial agents in biomedical fields. In this study, the spherical AgNPs with average sizes of 5nm were prepared using a dopamine reduction method. The in vitro study shows that AgNPs with the concentrations of 0.5μg/mL and 1μg/mL exhibit good biocompatibility

In this 21th century, the demand for glucose sensors in monitoring diabetes reaches a year-on-year peak due to the unhealthy lifestyle of society. Therefore, it is the utmost important task for scientists and researchers to develop a highly efficient and effective glucose sensor. However, conventional enzymatic glucose sensors have showed some drawbacks and the underlying issues faced by enzymatic

The next generation of artificial intelligence systems is generally governed by a new electronic element called memristor. Memristor-based computational system is responsible for confronting memory wall issues in conventional system architecture in the big data era. Complementary Metal Oxide Semiconductor (CMOS) compatibility, nonvolatility and scalability are the important properties of memristor

Enoxacin, as the broad-spectrum antibacterial activity antibiotics, has been widely used in treatment of bacterial diseases in animals and humans around the world. The extensive use of enoxacin in healthcare has also caused increasingly serious environmental risk as a matter of course. In this work, enoxacin imprinted poly (vinylidene fluoride) (PVDF) composite membranes (EIPCMs) were developed by

A subtle modification of the device surface is able to reduce optical loss and to further achieve high photoelectric conversion efficiency for thin film solar cells. This work shows the manipulation properties of subwavelength periodic structures on incident light at air/glass surface. In order to explore the mechanisms of optical loss, the spectral response and energy distribution of light are investigated

Nano-hydroxyapatite crystals of different morphologies were synthesized by adding two types of amino acids (glycine and arginine) under hydrothermal conditions. The XRD, FTIR, and TEM characterizations of samples showed that the final product was pure hydroxyapatite with high crystallinity. Organic small-molecule amino acids exhibited a significant inhibitory effect on crystal growth during the synthesis

A composite of methylammonium lead iodide perovskite (MAPbI3) and carbon dots is prepared under ultrasound irradiation. Characterizations of X-ray diffraction, Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, transmission electron microscopy, emission field scanning electron microscopy, Raman spectra and UV-Vis diffuse reflectance spectroscopy are performed. Excellent photoelectrochemical

Copper-palladium (CuPd)/boron nitride nanosheet (BNNS) nanocatalysts were successfully prepared by a microwave-assisted method by using BNNSs as a carrier. These catalysts with a low noble metal content had a high catalytic activity for Cr(VI) reduction at room temperature. The reaction rate reached 0.04044s−1, which was approximately 2.5 times that of Cu8Pd2/rGO with the same metal loading amount

In this work, graphene aerogels (GAs) with three-dimensional interconnected networks were prepared by chemical reduction and self-assembly of graphene oxide sheets. After microwave treatment, obtained microwave reduced graphene aerogels (MRGAs) were used in the preparation of bismaleimide (BMI) composites. The results show that the microwave treatment significantly enhanced the quality of GAs, and

Developing nonmetal-doped mesoporous TiO2 is highly attractive for preparing semiconductor visible photocatalyst with high activities. Here, we prepare N/F co-doped mesoporous TiO2 with high vis-photocatalytic activities by a simple liquid phase deposition process followed by annealing in air using C16TAB as a bi-functional template (forming mesoporous and providing dopants). N2 adsorption isotherms

Organic transistors are crucial components in future flexible electronics due to their excellent properties and ease of circuit integration. Previously, we demonstrated that flexible organic (polyimide) thermal transistors could be prepared using commercial graphite paper as the substrate. These materials exhibited excellent temperature sensitivity, linearity and recoverability due to the intrinsically

In this work, the function of 4-nitroimidazole (4-NIm) in the formation of Cr-MIL-101 was confirmed. It was found that 4-NIm is an effective additive in the formation of Cr-MIL-101 synthesized at lower temperature. The investigation of crystallization time showed that 4-NIm can prevent Cr-MIL-101 phase converting into Cr-MIL-53 phase. The effect of concentration of 4-NIm on the morphology and the yield

The development of low-cost, high-purity and high-performance porous carbon is of great significance for promoting the commercial application of supercapacitors. In this paper, porous carbon spheres (PCSs) with excellent electrochemical performance were obtained by carbonization and activation of starch gel spheres as precursor which is prepared by microemulsion process. The obtained PCSs exhibit both

Solid-state nanopores have shown great potential in investigating salinity gradient energy generation as a renewable power generator. In this work, various diameter silicon nitride (Si3N4) nanopores were fabricated to investigate the power generation between two potassium chloride solutions with different concentration gradient ratios by reverse electrodialysis. The maximal estimated power density

Silicon carbon nanoparticles (SCNPs) coated with reduced graphene oxide (rGO) were fabricated by a hydrothermal method and subsequently by a simple heat treatment process. SCNPs/rGO exhibit excellent electrochemical performance which not only attributes the rGO layer to inhibit the volumetric expansion of silicon and reduce the impedance between the active material and lithium ions during the electrochemical