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Genetic variant powers up immune cells that remember SARS-CoV-2 Nature (IF 64.8) Pub Date : 2023-09-29
People with a specific variant had more active thymus glands, which produce immune cells that fight off infection.
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“Couldn’t cut it as a scientist.” How lab managers and technicians are smashing outdated stereotypes Nature (IF 64.8) Pub Date : 2023-09-29
Support staff should speak up more about how their skills drive scientific discovery, says glassblower Terri Adams.
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Scientists are waiting longer than ever to receive a Nobel Nature (IF 64.8) Pub Date : 2023-09-29
Nobel laureates often receive the prize decades after their groundbreaking research — and that delay is getting longer.
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Master regulator of a mosquito X chromosome discovered Nature (IF 64.8) Pub Date : 2023-09-28 Maggie P. Lauria Sneideman, Victoria H. Meller
A mechanism for equalizing gene expression between sexes.
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What’s the best chatbot for me? Researchers put LLMs through their paces Nature (IF 64.8) Pub Date : 2023-09-27
When it comes to large language models, there’s one for every occasion. Find the most appropriate match for you in our AI speed-dating feature.
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Better awareness of RSV in older adults is needed to fight a growing burden Nature (IF 64.8) Pub Date : 2023-09-27
Respiratory syncytial virus is usually associated with babies, but the virus can also cause serious disease in older adults and people with chronic medical conditions.
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This is what Earth’s continents will look like in 250 million years Nature (IF 64.8) Pub Date : 2023-09-25
Only a fraction of the planet’s surface will be habitable to mammals when the next supercontinent, Pangaea Ultima, forms.
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Audio long read: These animals are racing towards extinction. A new home might be their last chance Nature (IF 64.8) Pub Date : 2023-09-29
Listen to an audio version of a recent Nature feature.
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The UK’s rollback of climate policies will cost its citizens and the world Nature (IF 64.8) Pub Date : 2023-09-29
Incoherent new climate-policy messages by Prime Minister Rishi Sunak will dissolve the UK’s climate leadership, stifle innovation’s momentum and cost consumers.
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Enhanced optoelectronic coupling for perovskite-silicon tandem solar cells Nature (IF 64.8) Pub Date : 2023-09-28 Erkan Aydin, Esma Ugur, Bumin K. Yildirim, Thomas G. Allen, Pia Dally, Arsalan Razzaq, Fangfang Cao, Lujia Xu, Badri Vishal, Aren Yazmaciyan, Ahmed A. Said, Shynggys Zhumagali, Randi Azmi, Maxime Babics, Andreas Fell, Chuanxiao Xiao, Stefaan De Wolf
Monolithic perovskite/silicon tandem solar cells are of great appeal as they promise high power conversion efficiencies (PCEs) at affordable cost. In state-of-the-art tandems, the perovskite top cell is electrically coupled to a silicon heterojunction bottom cell via a self-assembled monolayer (SAM), anchored on a transparent conductive oxide (TCO), which enables efficient charge transfer between the
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The sex-specific factor SOA controls dosage compensation in Anopheles mosquitos Nature (IF 64.8) Pub Date : 2023-09-28 Agata Izabela Kalita, Eric Marois, Magdalena Kozielska, Franz J. Weissing, Etienne Jaouen, Martin M. Möckel, Frank Rühle, Falk Butter, M. Felicia Basilicata, Claudia Isabelle Keller Valsecchi
The Anopheles mosquito is one of thousands of species in which sex differences play a central role in their biology, as only females need a blood meal in order to produce eggs. Sex differentiation is regulated by sex chromosomes, but their presence creates a dosage imbalance between males (XY) and females (XX). Dosage compensation (DC) can re-equilibrate the expression of sex-chromosomal genes, but
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Crack this kind of diamond, and it heals itself Nature (IF 64.8) Pub Date : 2023-09-28
Synthetic diamond recovers from fracture when carbon atoms on both sides of the gap form bonds with each other.
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The brain cells linked to protection against dementia Nature (IF 64.8) Pub Date : 2023-09-28
People with an abundance of specific neurons are more likely to escape cognitive decline despite having signs of Alzheimer’s in their brains.
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AI predicts how many earthquake aftershocks will strike — and their strength Nature (IF 64.8) Pub Date : 2023-09-28
Models trained on large data sets of seismic events can estimate the number of aftershocks better than conventional models do.
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Can AI predict who will win a Nobel Prize? Nature (IF 64.8) Pub Date : 2023-09-28
With a few modifications, ChatGPT-like models could enhance the art of identifying future laureates.
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How a US government shutdown could disrupt science Nature (IF 64.8) Pub Date : 2023-09-28
Tens of thousands of federal researchers might have to stop work on 1 October — but the shutdown’s effects could ripple well beyond government.
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Protected areas slow declines unevenly across the tetrapod tree of life Nature (IF 64.8) Pub Date : 2023-09-27 A. Justin Nowakowski, James I. Watling, Alexander Murray, Jessica L. Deichmann, Thomas S. Akre, Carlos L. Muñoz Brenes, Brian D. Todd, Louise McRae, Robin Freeman, Luke O. Frishkoff
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A bioelectrical phase transition patterns the first vertebrate heartbeats Nature (IF 64.8) Pub Date : 2023-09-27 Bill Z. Jia, Yitong Qi, J. David Wong-Campos, Sean G. Megason, Adam E. Cohen
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Dopaminergic error signals retune to social feedback during courtship Nature (IF 64.8) Pub Date : 2023-09-27 Andrea Roeser, Vikram Gadagkar, Anindita Das, Pavel A. Puzerey, Brian Kardon, Jesse H. Goldberg
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Scandium-45 nuclear-clock candidate driven by X-ray lasers Nature (IF 64.8) Pub Date : 2023-09-27
Nuclear resonance in scandium-45 excited by X-ray lasers could provide the basis for a highly precise and stable nuclear clock.
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Anomalous crystalline ordering of particles in a viscoelastic fluid under high shear Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2023-09-29 Sijie Sun, Nan Xue, Stefano Aime, Hyoungsoo Kim, Jizhou Tang, Gareth H. McKinley, Howard A. Stone, David A. Weitz
Addition of particles to a viscoelastic suspension dramatically alters the properties of the mixture, particularly when it is sheared or otherwise processed. Shear-induced stretching of the polymers results in elastic stress that causes a substantial increase in measured viscosity with increasing shear, and an attractive interaction between particles, leading to their chaining. At even higher shear
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Local extracellular K + in cortex regulates norepinephrine levels, network state, and behavioral output Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2023-09-29 Andrea Grostøl Dietz, Pia Weikop, Natalie Hauglund, Mie Andersen, Nicolas Caesar Petersen, Laura Rose, Hajime Hirase, Maiken Nedergaard
Extracellular potassium concentration ([K + ] e ) is known to increase as a function of arousal. [K + ] e is also a potent modulator of transmitter release. Yet, it is not known whether [K + ] e is involved in the neuromodulator release associated with behavioral transitions. We here show that manipulating [K + ] e controls the local release of monoaminergic neuromodulators, including norepinephrine
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Multiomic prediction of therapeutic targets for human diseases associated with protein phase separation Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2023-09-29 Christine M. Lim, Alicia González Díaz, Monika Fuxreiter, Frank W. Pun, Alex Zhavoronkov, Michele Vendruscolo
The phenomenon of protein phase separation (PPS) underlies a wide range of cellular functions. Correspondingly, the dysregulation of the PPS process has been associated with numerous human diseases. To enable therapeutic interventions based on the regulation of this association, possible targets should be identified. For this purpose, we present an approach that combines the multiomic PandaOmics platform
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Maternally derived antibody titer dynamics and risk of hospitalized infant dengue disease Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2023-09-29 Megan O’Driscoll, Darunee Buddhari, Angkana T. Huang, Adam Waickman, Surachai Kaewhirun, Sopon Iamsirithaworn, Direk Khampaen, Aaron Farmer, Stefan Fernandez, Isabel Rodriguez-Barraquer, Anon Srikiatkhachorn, Stephen Thomas, Timothy Endy, Alan L. Rothman, Kathryn Anderson, Derek A. T. Cummings, Henrik Salje
Infants less than 1 y of age experience high rates of dengue disease in dengue virus (DENV) endemic countries. This burden is commonly attributed to antibody-dependent enhancement (ADE), whereby concentrations of maternally derived DENV antibodies become subneutralizing, and infection-enhancing. Understanding antibody-related mechanisms of enhanced infant dengue disease risk represents a significant
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The ozone layer’s comeback brings a chill to Antarctica’s ocean Nature (IF 64.8) Pub Date : 2023-09-28
Ozone recovery is predicted to shift westerly winds, which will reduce the amount of warm water flowing into the Southern Ocean.
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Digging up ancient animals in Amazonia Nature (IF 64.8) Pub Date : 2023-09-28
Laurent Marivaux works to identify ancient mammals to understand evolutionary history in South America.
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Proteome census upon nutrient stress reveals Golgiphagy membrane receptors Nature (IF 64.8) Pub Date : 2023-09-27 Kelsey L. Hickey, Sharan Swarup, Ian R. Smith, Julia C. Paoli, Enya Miguel Whelan, Joao A. Paulo, J. Wade Harper
During nutrient stress, macroautophagy degrades cellular macromolecules, thereby providing biosynthetic building blocks while simultaneously remodeling the proteome1,2. While machinery responsible for initiation of macroautophagy is well characterized3,4, our understanding of the extent to which individual proteins, protein complexes and organelles are selected for autophagic degradation, and the underlying
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The very first beat: how a heart starts to pulse Nature (IF 64.8) Pub Date : 2023-09-27
Hours of footage of zebrafish embryos let researchers capture and study this key moment in development.
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Scientists achieve the tricky task of compressing liquids Nature (IF 64.8) Pub Date : 2023-09-27
Using a metal–organic framework, researchers reduced the volume of a water-based mixture by 7%.
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Observation of the effect of gravity on the motion of antimatter Nature (IF 64.8) Pub Date : 2023-09-27 E. K. Anderson, C. J. Baker, W. Bertsche, N. M. Bhatt, G. Bonomi, A. Capra, I. Carli, C. L. Cesar, M. Charlton, A. Christensen, R. Collister, A. Cridland Mathad, D. Duque Quiceno, S. Eriksson, A. Evans, N. Evetts, S. Fabbri, J. Fajans, A. Ferwerda, T. Friesen, M. C. Fujiwara, D. R. Gill, L. M. Golino, M. B. Gomes Gonçalves, P. Grandemange, P. Granum, J. S. Hangst, M. E. Hayden, D. Hodgkinson, E. D
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Uniquely preserved gut contents illuminate trilobite palaeophysiology Nature (IF 64.8) Pub Date : 2023-09-27 Petr Kraft, Valéria Vaškaninová, Michal Mergl, Petr Budil, Oldřich Fatka, Per E. Ahlberg
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Weather explains the decline and rise of insect biomass over 34 years Nature (IF 64.8) Pub Date : 2023-09-27 Jörg Müller, Torsten Hothorn, Ye Yuan, Sebastian Seibold, Oliver Mitesser, Julia Rothacher, Julia Freund, Clara Wild, Marina Wolz, Annette Menzel
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Seasonal advance of intense tropical cyclones in a warming climate Nature (IF 64.8) Pub Date : 2023-09-27 Kaiyue Shan, Yanluan Lin, Pao-Shin Chu, Xiping Yu, Fengfei Song
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The geography of climate and the global patterns of species diversity Nature (IF 64.8) Pub Date : 2023-09-27 Marco Túlio P. Coelho, Elisa Barreto, Thiago F. Rangel, José Alexandre F. Diniz-Filho, Rafael O. Wüest, Wilhelmine Bach, Alexander Skeels, Ian R. McFadden, David W. Roberts, Loïc Pellissier, Niklaus E. Zimmermann, Catherine H. Graham
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A quantum engine in the BEC–BCS crossover Nature (IF 64.8) Pub Date : 2023-09-27 Jennifer Koch, Keerthy Menon, Eloisa Cuestas, Sian Barbosa, Eric Lutz, Thomás Fogarty, Thomas Busch, Artur Widera
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Electrically driven organic laser using integrated OLED pumping Nature (IF 64.8) Pub Date : 2023-09-27 Kou Yoshida, Junyi Gong, Alexander L. Kanibolotsky, Peter J. Skabara, Graham A. Turnbull, Ifor D. W. Samuel
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Inactivation of the Kv2.1 channel through electromechanical coupling Nature (IF 64.8) Pub Date : 2023-09-27 Ana I. Fernández-Mariño, Xiao-Feng Tan, Chanhyung Bae, Kate Huffer, Jiansen Jiang, Kenton J. Swartz
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Precessing jet nozzle connecting to a spinning black hole in M87 Nature (IF 64.8) Pub Date : 2023-09-27 Yuzhu Cui, Kazuhiro Hada, Tomohisa Kawashima, Motoki Kino, Weikang Lin, Yosuke Mizuno, Hyunwook Ro, Mareki Honma, Kunwoo Yi, Jintao Yu, Jongho Park, Wu Jiang, Zhiqiang Shen, Evgeniya Kravchenko, Juan-Carlos Algaba, Xiaopeng Cheng, Ilje Cho, Gabriele Giovannini, Marcello Giroletti, Taehyun Jung, Ru-Sen Lu, Kotaro Niinuma, Junghwan Oh, Ken Ohsuga, Satoko Sawada-Satoh, Bong Won Sohn, Hiroyuki R. Takahashi
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Transposon-encoded nucleases use guide RNAs to promote their selfish spread Nature (IF 64.8) Pub Date : 2023-09-27 Chance Meers, Hoang C. Le, Sanjana R. Pesari, Florian T. Hoffmann, Matt W. G. Walker, Jeanine Gezelle, Stephen Tang, Samuel H. Sternberg
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Earth’s early continental crust formed from wet and oxidizing arc magmas Nature (IF 64.8) Pub Date : 2023-09-27 Rong-Feng Ge, Simon A. Wilde, Wen-Bin Zhu, Xiao-Lei Wang
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Inhibition of fatty acid oxidation enables heart regeneration in adult mice Nature (IF 64.8) Pub Date : 2023-09-27 Xiang Li, Fan Wu, Stefan Günther, Mario Looso, Carsten Kuenne, Ting Zhang, Marion Wiesnet, Stephan Klatt, Sven Zukunft, Ingrid Fleming, Gernot Poschet, Astrid Wietelmann, Ann Atzberger, Michael Potente, Xuejun Yuan, Thomas Braun
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Molecular pathology of neurodegenerative diseases by cryo-EM of amyloids Nature (IF 64.8) Pub Date : 2023-09-27 Sjors H. W. Scheres, Benjamin Ryskeldi-Falcon, Michel Goedert
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Assembloid CRISPR screens reveal impact of disease genes in human neurodevelopment Nature (IF 64.8) Pub Date : 2023-09-27 Xiangling Meng, David Yao, Kent Imaizumi, Xiaoyu Chen, Kevin W. Kelley, Noah Reis, Mayuri Vijay Thete, Arpana Arjun McKinney, Shravanti Kulkarni, Georgia Panagiotakos, Michael C. Bassik, Sergiu P. Pașca
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Spatial atlas of the mouse central nervous system at molecular resolution Nature (IF 64.8) Pub Date : 2023-09-27 Hailing Shi, Yichun He, Yiming Zhou, Jiahao Huang, Kamal Maher, Brandon Wang, Zefang Tang, Shuchen Luo, Peng Tan, Morgan Wu, Zuwan Lin, Jingyi Ren, Yaman Thapa, Xin Tang, Ken Y. Chan, Benjamin E. Deverman, Hao Shen, Albert Liu, Jia Liu, Xiao Wang
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piRNA processing by a trimeric Schlafen-domain nuclease Nature (IF 64.8) Pub Date : 2023-09-27 Nadezda Podvalnaya, Alfred W. Bronkhorst, Raffael Lichtenberger, Svenja Hellmann, Emily Nischwitz, Torben Falk, Emil Karaulanov, Falk Butter, Sebastian Falk, René F. Ketting
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Resonant X-ray excitation of the nuclear clock isomer 45Sc Nature (IF 64.8) Pub Date : 2023-09-27 Yuri Shvyd’ko, Ralf Röhlsberger, Olga Kocharovskaya, Jörg Evers, Gianluca Aldo Geloni, Peifan Liu, Deming Shu, Antonino Miceli, Brandon Stone, Willi Hippler, Berit Marx-Glowna, Ingo Uschmann, Robert Loetzsch, Olaf Leupold, Hans-Christian Wille, Ilya Sergeev, Miriam Gerharz, Xiwen Zhang, Christian Grech, Marc Guetg, Vitali Kocharyan, Naresh Kujala, Shan Liu, Weilun Qin, Alexey Zozulya, Jörg Hallmann
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An all-organic laser that is electrically driven Nature (IF 64.8) Pub Date : 2023-09-27 Stéphane Kéna-Cohen
All-organic LED-driven laser.
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Measuring the ecological benefits of protected areas Nature (IF 64.8) Pub Date : 2023-09-27 Ana S. L. Rodrigues, Marie-Morgane Rouyer
Global-scale assessment of the effectiveness of a key conservation tool.
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Universities axe diversity statements in wake of US Supreme Court ruling on affirmative action Nature (IF 64.8) Pub Date : 2023-09-27
Higher-education campaigners fear that removing the option for job applicants to provide the statements will make the academic workforce less diverse.
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Coordinating the first heartbeat Nature (IF 64.8) Pub Date : 2023-09-27 Joshua Bloomekatz, Neil C. Chi
How calcium waves organize and propagate across the developing heart.
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This isn’t the Nature Podcast — how deepfakes are distorting reality Nature (IF 64.8) Pub Date : 2023-09-27
The rise of AI-generated fakes, evidence of the earliest-known wooden structure, and how NASA’s OSIRIS-REx brought asteroid samples back to Earth.
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Daily briefing: See the first image released by China’s new high-resolution telescope Nature (IF 64.8) Pub Date : 2023-09-27
The Wide Field Survey Telescope will scan the skies for stellar explosions. Plus, how to do science in a violent border region and how much we owe to earthworms.
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A trilobite’s last meal reveals feeding behaviour and physiology Nature (IF 64.8) Pub Date : 2023-09-27
Imaging shows that the marine arthropod had feasted on small shelly invertebrates.
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Boomerang academics: why we left academia for industry, but then came back Nature (IF 64.8) Pub Date : 2023-09-27
A move from one sector to another isn’t a one-way street. Researchers who have pivoted between the two explain why.
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Antimatter falls down, not up: CERN experiment confirms theory Nature (IF 64.8) Pub Date : 2023-09-27
Observing this simple phenomenon had eluded physicists for decades.
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This octopus-inspired patch could deliver drugs like Ozempic through your cheek Nature (IF 64.8) Pub Date : 2023-09-27
Small rubber suction cups filled with medication were better than tablets at delivering compounds into the bloodstream.
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Flying Mars rocks to Earth could cost an astronomical $11 billion Nature (IF 64.8) Pub Date : 2023-09-27
NASA’s Perseverance rover has collected valuable samples, but a new report says the plan to fetch them is unworkable.
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The geography of climate governs biodiversity Nature (IF 64.8) Pub Date : 2023-09-27 Antonin Machac
New approach for analysing global patterns of biodiversity.
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Global warming is advancing the season for intense tropical cyclones Nature (IF 64.8) Pub Date : 2023-09-27
A data analysis shows that intense tropical cyclones are shifting earlier in the season all over the globe, owing mainly to anthropogenic climate warming.
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Free-falling antihydrogen reveals the effect of gravity on antimatter Nature (IF 64.8) Pub Date : 2023-09-27 Anna Soter
Test shows antimatter is pulled by gravity.