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Structured ionized winds shooting out from a quasar at relativistic speeds Nature (IF 50.5) Pub Date : 2025-05-14
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Past warm intervals inform the future South Asian summer monsoon Nature (IF 50.5) Pub Date : 2025-05-14 Linqiang He, Tianjun Zhou, Zhun Guo
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Exploring pathways for world development within planetary boundaries Nature (IF 50.5) Pub Date : 2025-05-14 Detlef P. van Vuuren, Jonathan C. Doelman, Isabela Schmidt Tagomori, Arthur H. W. Beusen, Sarah E. Cornell, Johan Röckstrom, Aafke M. Schipper, Elke Stehfest, Geanderson Ambrosio, Maarten van den Berg, Lex Bouwman, Vassilis Daioglou, Mathijs Harmsen, Paul Lucas, Kaj-Ivar van der Wijst, Willem-Jan van Zeist
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Radiation-induced amphiregulin drives tumour metastasis Nature (IF 50.5) Pub Date : 2025-05-14 András Piffkó, Kaiting Yang, Arpit Panda, Janna Heide, Krystyna Tesak, Chuangyu Wen, Katarzyna Zawieracz, Liangliang Wang, Emile Z. Naccasha, Jason Bugno, Yanbin Fu, Dapeng Chen, Leonhard Donle, Ernst Lengyel, Douglas G. Tilley, Matthias Mack, Ronald S. Rock, Steven J. Chmura, Everett E. Vokes, Chuan He, Sean P. Pitroda, Hua Laura Liang, Ralph R. Weichselbaum
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Taurine from tumour niche drives glycolysis to promote leukaemogenesis Nature (IF 50.5) Pub Date : 2025-05-14 Sonali Sharma, Benjamin J. Rodems, Cameron D. Baker, Christina M. Kaszuba, Edgardo I. Franco, Bradley R. Smith, Takashi Ito, Kyle Swovick, Kevin Welle, Yi Zhang, Philip Rock, Francisco A. Chaves, Sina Ghaemmaghami, Laura M. Calvi, Archan Ganguly, W. Richard Burack, Michael W. Becker, Jane L. Liesveld, Paul S. Brookes, Joshua C. Munger, Craig T. Jordan, John M. Ashton, Jeevisha Bajaj
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Encapsulated Co–Ni alloy boosts high-temperature CO2 electroreduction Nature (IF 50.5) Pub Date : 2025-05-14 Wenchao Ma, Jordi Morales-Vidal, Jiaming Tian, Meng-Ting Liu, Seongmin Jin, Wenhao Ren, Julian Taubmann, Christodoulos Chatzichristodoulou, Jeremy Luterbacher, Hao Ming Chen, Núria López, Xile Hu
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Proton transport from the antimatter factory of CERN Nature (IF 50.5) Pub Date : 2025-05-14 M. Leonhardt, D. Schweitzer, F. Abbass, K. K. Anjum, B. Arndt, S. Erlewein, S. Endoh, P. Geissler, T. Imamura, J. I. Jäger, B. M. Latacz, P. Micke, F. Voelksen, H. Yildiz, K. Blaum, J. A. Devlin, Y. Matsuda, C. Ospelkaus, W. Quint, A. Soter, J. Walz, Y. Yamazaki, S. Ulmer, C. Smorra
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Divergent DNA methylation dynamics in marsupial and eutherian embryos Nature (IF 50.5) Pub Date : 2025-05-14 Bryony J. Leeke, Wazeer Varsally, Sugako Ogushi, Jasmin Zohren, Sergio Menchero, Aurélien Courtois, Daniel M. Snell, Aurélie Teissandier, Obah Ojarikre, Shantha K. Mahadevaiah, Fanny Decarpentrie, Rebecca J. Oakey, John L. VandeBerg, James M. A. Turner
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A human-specific enhancer fine-tunes radial glia potency and corticogenesis Nature (IF 50.5) Pub Date : 2025-05-14 Jing Liu, Federica Mosti, Hanzhi T. Zhao, Davoneshia Lollis, Jesus E. Sotelo-Fonseca, Carla F. Escobar-Tomlienovich, Camila M. Musso, Yiwei Mao, Abdull J. Massri, Hannah M. Doll, Nicole D. Moss, Andre M. M. Sousa, Gregory A. Wray, Ewoud R. E. Schmidt, Debra L. Silver
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Chicago Archaeopteryx informs on the early evolution of the avian bauplan Nature (IF 50.5) Pub Date : 2025-05-14 Jingmai O’Connor, Alexander Clark, Pei-Chen Kuo, Yosef Kiat, Matteo Fabbri, Akiko Shinya, Constance Van Beek, Jing Lu, Min Wang, Han Hu
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Earliest amniote tracks recalibrate the timeline of tetrapod evolution Nature (IF 50.5) Pub Date : 2025-05-14 John A. Long, Grzegorz Niedźwiedzki, Jillian Garvey, Alice M. Clement, Aaron B. Camens, Craig A. Eury, John Eason, Per E. Ahlberg
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Wireless transmission of internal hazard signals in Li-ion batteries Nature (IF 50.5) Pub Date : 2025-05-14 Jinbao Fan, Chenchen Liu, Na Li, Le Yang, Xiao-Guang Yang, Bowen Dou, Shujuan Hou, Xuning Feng, Hanqing Jiang, Hong Li, Wei-Li Song, Lei Sun, Hao-Sen Chen, Huajian Gao, Daining Fang
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Ultrahigh-pressure crystallographic passage towards metallic hydrogen Nature (IF 50.5) Pub Date : 2025-05-14 Cheng Ji, Bing Li, Jie Luo, Yongsheng Zhao, Yuan Liu, Konstantin Glazyrin, Alexander Björling, Lucas A. B. Marçal, Maik Kahnt, Sebastian Kalbfleisch, Wenjun Liu, Yang Gao, Junyue Wang, Wendy L. Mao, Hanyu Liu, Yanming Ma, Yang Ding, Wenge Yang, Ho-Kwang Mao
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Targeting symbionts by apolipoprotein L proteins modulates gut immunity Nature (IF 50.5) Pub Date : 2025-05-14 Tao Yang, Xiaohu Hu, Fei Cao, Fenglin Yun, Kaiwen Jia, Mingxiang Zhang, Gaohui Kong, Biyu Nie, Yuexing Liu, Haohao Zhang, Xiaoyu Li, Hongyan Gao, Jiantao Shi, Guanxiang Liang, Guohong Hu, Dennis L. Kasper, Xinyang Song, Youcun Qian
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STAT5 and STAT3 balance shapes dendritic cell function and tumour immunity Nature (IF 50.5) Pub Date : 2025-05-14 Jiajia Zhou, Kole Tison, Haibin Zhou, Longchuan Bai, Ranjan Kumar Acharyya, Donna McEachern, Hoda Metwally, Yu Wang, Michael Pitter, Jae Eun Choi, Linda Vatan, Peng Liao, Jiali Yu, Heng Lin, Long Jiang, Shuang Wei, Xue Gao, Sara Grove, Abhijit Parolia, Marcin Cieslik, Ilona Kryczek, Michael D. Green, Jian-Xin Lin, Arul M. Chinnaiyan, Warren J. Leonard, Shaomeng Wang, Weiping Zou
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Bulk–spatiotemporal vortex correspondence in gyromagnetic zero-index media Nature (IF 50.5) Pub Date : 2025-05-14 Ruo-Yang Zhang, Xiaohan Cui, Yuan-Song Zeng, Jin Chen, Wenzhe Liu, Mudi Wang, Dongyang Wang, Zhao-Qing Zhang, Neng Wang, Geng-Bo Wu, C. T. Chan
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Interferon-γ orchestrates leptomeningeal anti-tumour response Nature (IF 50.5) Pub Date : 2025-05-14 Jan Remsik, Xinran Tong, Russell Z. Kunes, Min Jun Li, Rachel Estrera, Jenna Snyder, Clark Thomson, Ahmed M. Osman, Kiana Chabot, Ugur T. Sener, Jessica A. Wilcox, Danielle Isakov, Helen Wang, Tejus A. Bale, Ronan Chaligné, Joseph C. Sun, Chrysothemis Brown, Dana Pe’er, Adrienne Boire
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Systems consolidation reorganizes hippocampal engram circuitry Nature (IF 50.5) Pub Date : 2025-05-14 Sangyoon Y. Ko, Yiming Rong, Adam I. Ramsaran, Xiaoyu Chen, Asim J. Rashid, Andrew J. Mocle, Jagroop Dhaliwal, Ankit Awasthi, Axel Guskjolen, Sheena A. Josselyn, Paul W. Frankland
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Tunable vacuum-field control of fractional and integer quantum Hall phases Nature (IF 50.5) Pub Date : 2025-05-14 Josefine Enkner, Lorenzo Graziotto, Dalin Boriçi, Felice Appugliese, Christian Reichl, Giacomo Scalari, Nicolas Regnault, Werner Wegscheider, Cristiano Ciuti, Jérôme Faist
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Genome diversity and signatures of natural selection in mainland Southeast Asia Nature (IF 50.5) Pub Date : 2025-05-14 Yaoxi He, Xiaoming Zhang, Min-Sheng Peng, Yu-Chun Li, Kai Liu, Yu Zhang, Leyan Mao, Yongbo Guo, Yujie Ma, Bin Zhou, Wangshan Zheng, Tian Yue, Yuwen Liao, Shen-Ao Liang, Lu Chen, Weijie Zhang, Xiaoning Chen, Bixia Tang, Xiaofei Yang, Kai Ye, Shenghan Gao, Yurun Lu, Yong Wang, Shijie Wan, Rushan Hao, Xuankai Wang, Yafei Mao, Shanshan Dai, Zongliang Gao, Li-Qin Yang, Jianxin Guo, Jiangguo Li, Chao Liu
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Quantum error correction of qudits beyond break-even Nature (IF 50.5) Pub Date : 2025-05-14 Benjamin L. Brock, Shraddha Singh, Alec Eickbusch, Volodymyr V. Sivak, Andy Z. Ding, Luigi Frunzio, Steven M. Girvin, Michel H. Devoret
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Oncogenic fusions converge on shared mechanisms in initiating astroblastoma Nature (IF 50.5) Pub Date : 2025-05-14 Yixing Shi, Qianqian Sun, Fuchuan Jia, Xiangyu Xie, Xiangyu Zhou, Rong Guo, Yangfan Zeng, Shanshan Chen, Zhenzhen Guo, Wenli Sun, Tong Guo, Yu Xia, Wenlong Li, Li Zhang, Wei Shi, Yang Yu
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Spatial transcriptomics reveals human cortical layer and area specification Nature (IF 50.5) Pub Date : 2025-05-14 Xuyu Qian, Kyle Coleman, Shunzhou Jiang, Andrea J. Kriz, Jack H. Marciano, Chunyu Luo, Chunhui Cai, Monica Devi Manam, Emre Caglayan, Abbe Lai, David Exposito-Alonso, Aoi Otani, Urmi Ghosh, Diane D. Shao, Rebecca E. Andersen, Jennifer E. Neil, Robert Johnson, Alexandra LeFevre, Jonathan L. Hecht, Nicola Micali, Nenad Sestan, Pasko Rakic, Michael B. Miller, Liang Sun, Carsen Stringer, Mingyao Li, Christopher
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Solid phase transitions as a solution to the genome folding paradox Nature (IF 50.5) Pub Date : 2025-05-14 Joan Pulupa, Natalie G. McArthur, Olga Stathi, Miao Wang, Marianna Zazhytska, Isabella D. Pirozzolo, Ahana Nayar, Lawrence Shapiro, Stavros Lomvardas
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Unconventional domain tessellations in moiré-of-moiré lattices Nature (IF 50.5) Pub Date : 2025-05-14 Daesung Park, Changwon Park, Kunihiro Yananose, Eunjung Ko, Byunghyun Kim, Rebecca Engelke, Xi Zhang, Konstantin Davydov, Matthew Green, Hyun-Mi Kim, Sang Hwa Park, Jae Heon Lee, Seul-Gi Kim, Hyeongkeun Kim, Kenji Watanabe, Takashi Taniguchi, Sang Mo Yang, Ke Wang, Philip Kim, Young-Woo Son, Hyobin Yoo
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Emergence of Calabi–Yau manifolds in high-precision black-hole scattering Nature (IF 50.5) Pub Date : 2025-05-14 Mathias Driesse, Gustav Uhre Jakobsen, Albrecht Klemm, Gustav Mogull, Christoph Nega, Jan Plefka, Benjamin Sauer, Johann Usovitsch
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Dopaminergic action prediction errors serve as a value-free teaching signal Nature (IF 50.5) Pub Date : 2025-05-14 Francesca Greenstreet, Hernando Martinez Vergara, Yvonne Johansson, Sthitapranjya Pati, Laura Schwarz, Stephen C. Lenzi, Jesse P. Geerts, Matthew Wisdom, Alina Gubanova, Lars B. Rollik, Jasvin Kaur, Theodore Moskovitz, Joseph Cohen, Emmett Thompson, Troy W. Margrie, Claudia Clopath, Marcus Stephenson-Jones
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Water ice in the debris disk around HD 181327 Nature (IF 50.5) Pub Date : 2025-05-14 Chen Xie, Christine H. Chen, Carey M. Lisse, Dean C. Hines, Tracy Beck, Sarah K. Betti, Noemí Pinilla-Alonso, Carl Ingebretsen, Kadin Worthen, András Gáspár, Schuyler G. Wolff, Bryce T. Bolin, Laurent Pueyo, Marshall D. Perrin, John A. Stansberry, Jarron M. Leisenring
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Prefrontal encoding of an internal model for emotional inference Nature (IF 50.5) Pub Date : 2025-05-14 Xiaowei Gu, Joshua P. Johansen
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Thermal asymmetry in the Moon’s mantle inferred from monthly tidal response Nature (IF 50.5) Pub Date : 2025-05-14 R. S. Park, A. Berne, A. S. Konopliv, J. T. Keane, I. Matsuyama, F. Nimmo, M. Rovira-Navarro, M. P. Panning, M. Simons, D. J. Stevenson, R. C. Weber
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Global emergence of unprecedented lifetime exposure to climate extremes Nature (IF 50.5) Pub Date : 2025-05-07 Luke Grant, Inne Vanderkelen, Lukas Gudmundsson, Erich Fischer, Sonia I. Seneviratne, Wim Thiery
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Twist-programmable superconductivity in spin–orbit-coupled bilayer graphene Nature (IF 50.5) Pub Date : 2025-05-07 Yiran Zhang, Gal Shavit, Huiyang Ma, Youngjoon Han, Chi Wang Siu, Ankan Mukherjee, Kenji Watanabe, Takashi Taniguchi, David Hsieh, Cyprian Lewandowski, Felix von Oppen, Yuval Oreg, Stevan Nadj-Perge
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PLA2G15 is a BMP hydrolase and its targeting ameliorates lysosomal disease Nature (IF 50.5) Pub Date : 2025-05-07 Kwamina Nyame, Jian Xiong, Hisham N. Alsohybe, Arthur P. H. de Jong, Isabelle V. Peña, Ricardo de Miguel, Thijn R. Brummelkamp, Guido Hartmann, Sebastian M. B. Nijman, Matthijs Raaben, Judith A. Simcox, Vincent A. Blomen, Monther Abu-Remaileh
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Bioremediation of complex organic pollutants by engineered Vibrio natriegens Nature (IF 50.5) Pub Date : 2025-05-07 Cong Su, Haotian Cui, Weiwei Wang, Yong Liu, Zhenyu Cheng, Chen Wang, Mengqiao Yang, Liwen Qu, Ye Li, Yuejin Cai, Siyang He, Jiaxin Zheng, Pingping Zhao, Ping Xu, Junbiao Dai, Hongzhi Tang
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Intragrain 3D perovskite heterostructure for high-performance pure-red perovskite LEDs Nature (IF 50.5) Pub Date : 2025-05-07 Yong-Hui Song, Bo Li, Zi-Jian Wang, Xiao-Lin Tai, Guan-Jie Ding, Zi-Du Li, Huaiyu Xu, Jing-Ming Hao, Kuang-Hui Song, Li-Zhe Feng, Ya-Lan Hu, Yi-Chen Yin, Bai-Sheng Zhu, Guozhen Zhang, Huanxin Ju, Guanhaojie Zheng, Wei Hu, Yue Lin, Fengjia Fan, Hong-Bin Yao
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Light-microscopy-based connectomic reconstruction of mammalian brain tissue Nature (IF 50.5) Pub Date : 2025-05-07 Mojtaba R. Tavakoli, Julia Lyudchik, Michał Januszewski, Vitali Vistunou, Nathalie Agudelo Dueñas, Jakob Vorlaufer, Christoph Sommer, Caroline Kreuzinger, Bárbara Oliveira, Alban Cenameri, Gaia Novarino, Viren Jain, Johann G. Danzl
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Oncogene aberrations drive medulloblastoma progression, not initiation Nature (IF 50.5) Pub Date : 2025-05-07 Konstantin Okonechnikov, Piyush Joshi, Verena Körber, Anne Rademacher, Michele Bortolomeazzi, Jan-Philipp Mallm, Jan Vaillant, Patricia Benites Goncalves da Silva, Britta Statz, Mari Sepp, Ioannis Sarropoulos, Tetsuya Yamada, Andrea Wittmann, Kathrin Schramm, Mirjam Blattner-Johnson, Petra Fiesel, Barbara Jones, Natalie Jäger, Till Milde, Kristian W. Pajtler, Cornelis M. van Tilburg, Olaf Witt, Konrad
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Striatum supports fast learning but not memory recall Nature (IF 50.5) Pub Date : 2025-05-07 Kimberly Reinhold, Marci Iadarola, Shi Tang, Annabel Chang, Whitney Kuwamoto, Madeline A. Albanese, Senmiao Sun, Richard Hakim, Joshua Zimmer, Wengang Wang, Bernardo L. Sabatini
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Heterogeneous pericoerulear neurons tune arousal and exploratory behaviours Nature (IF 50.5) Pub Date : 2025-05-07 Andrew T. Luskin, Li Li, Xiaonan Fu, Madison M. Martin, Kelsey Barcomb, Kasey S. Girven, Taylor Blackburn, Bailey A. Wells, Sarah T. Thai, Esther M. Li, Akshay N. Rana, Rhiana C. Simon, Li Sun, Lei Gao, Alexandria D. Murry, Sam A. Golden, Garret D. Stuber, Christopher P. Ford, Liangcai Gu, Michael R. Bruchas
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Dopamine D1–D2 signalling in hippocampus arbitrates approach and avoidance Nature (IF 50.5) Pub Date : 2025-05-07 Arthur Godino, Marine Salery, Angelica M. Minier-Toribio, Vishwendra Patel, John F. Fullard, Veronika Kondev, Eric M. Parise, Freddyson J. Martinez-Rivera, Carole Morel, Panos Roussos, Robert D. Blitzer, Eric J. Nestler
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Targeting the SHOC2–RAS interaction in RAS-mutant cancers Nature (IF 50.5) Pub Date : 2025-05-07 Zachary J. Hauseman, Frédéric Stauffer, Kim S. Beyer, Sandra Mollé, Elena Cavicchioli, Jean-Remy Marchand, Michelle Fodor, Jessica Viscomi, Anxhela Dhembi, Stéphanie Katz, Beatrice Faggion, Mylene Lanter, Grainne Kerr, Daniela Schildknecht, Cornelia Handl, Danilo Maddalo, Carole Pissot Soldermann, Jacob Brady, Om Shrestha, Zachary Nguyen, Lukas Leder, Gregor Cremosnik, Sandra Lopez Romero, Ulrich Hassiepen
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Herring spawned poleward following fishery-induced collective memory loss Nature (IF 50.5) Pub Date : 2025-05-07 Aril Slotte, Are Salthaug, Sindre Vatnehol, Espen Johnsen, Erik Askov Mousing, Åge Høines, Cecilie Thorsen Broms, Sigurvin Bjarnason, Eydna í Homrum, Øystein Skagseth, Erling Kåre Stenevik
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Trends in the seasonal amplitude of atmospheric methane Nature (IF 50.5) Pub Date : 2025-05-07 Gang Liu, Lu Shen, Philippe Ciais, Xin Lin, Didier Hauglustaine, Xin Lan, Alexander J. Turner, Yi Xi, Yu Zhu, Shushi Peng
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Native nucleosomes intrinsically encode genome organization principles Nature (IF 50.5) Pub Date : 2025-05-07 Sangwoo Park, Raquel Merino-Urteaga, Violetta Karwacki-Neisius, Gustavo Ezequiel Carrizo, Advait Athreya, Alberto Marin-Gonzalez, Nils A. Benning, Jonghan Park, Michelle M. Mitchener, Natarajan V. Bhanu, Benjamin A. Garcia, Bin Zhang, Tom W. Muir, Erika L. Pearce, Taekjip Ha
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Superconductivity and spin canting in spin–orbit-coupled trilayer graphene Nature (IF 50.5) Pub Date : 2025-05-07 Caitlin L. Patterson, Owen I. Sheekey, Trevor B. Arp, Ludwig F. W. Holleis, Jin Ming Koh, Youngjoon Choi, Tian Xie, Siyuan Xu, Yi Guo, Hari Stoyanov, Evgeny Redekop, Canxun Zhang, Grigory Babikyan, David Gong, Haoxin Zhou, Xiang Cheng, Takashi Taniguchi, Kenji Watanabe, Martin E. Huber, Chenhao Jin, Étienne Lantagne-Hurtubise, Jason Alicea, Andrea F. Young
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Deep origin of eukaryotes outside Heimdallarchaeia within Asgardarchaeota Nature (IF 50.5) Pub Date : 2025-05-07 Jiawei Zhang, Xiaoyuan Feng, Meng Li, Yang Liu, Min Liu, Li-Jun Hou, Hong-Po Dong
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Activation of lysosomal iron triggers ferroptosis in cancer Nature (IF 50.5) Pub Date : 2025-05-07 Tatiana Cañeque, Leeroy Baron, Sebastian Müller, Alanis Carmona, Ludovic Colombeau, Antoine Versini, Stéphanie Solier, Christine Gaillet, Fabien Sindikubwabo, Julio L. Sampaio, Marie Sabatier, Eikan Mishima, Armel Picard-Bernes, Laurène Syx, Nicolas Servant, Bérangère Lombard, Damarys Loew, Jiashuo Zheng, Bettina Proneth, Leishemba K. Thoidingjam, Laurence Grimaud, Cameron S. Fraser, Krystina J. Szylo
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Nasal vaccines for respiratory infections Nature (IF 50.5) Pub Date : 2025-05-07 Hiroshi Kiyono, Peter B. Ernst
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Motor learning refines thalamic influence on motor cortex Nature (IF 50.5) Pub Date : 2025-05-07 Assaf Ramot, Felix H. Taschbach, Yun C. Yang, Yuxin Hu, Qiyu Chen, Bobbie C. Morales, Xinyi C. Wang, An Wu, Kay M. Tye, Marcus K. Benna, Takaki Komiyama
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A cryptic role for reciprocal helping in a cooperatively breeding bird Nature (IF 50.5) Pub Date : 2025-05-07 Alexis D. Earl, Gerald G. Carter, Arden G. Berlinger, Elkana Korir, Shailee S. Shah, Wilson N. Watetu, Dustin R. Rubenstein
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Chromatin loops are an ancestral hallmark of the animal regulatory genome Nature (IF 50.5) Pub Date : 2025-05-07 Iana V. Kim, Cristina Navarrete, Xavier Grau-Bové, Marta Iglesias, Anamaria Elek, Grygoriy Zolotarov, Nikolai S. Bykov, Sean A. Montgomery, Ewa Ksiezopolska, Didac Cañas-Armenteros, Joan J. Soto-Angel, Sally P. Leys, Pawel Burkhardt, Hiroshi Suga, Alex de Mendoza, Marc A. Marti-Renom, Arnau Sebé-Pedrós
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A kinase mediator of rhizobial symbiosis and immunity in Medicago Nature (IF 50.5) Pub Date : 2025-05-06 Dapeng Wang, Rui Jin, Xiaobao Shi, Haoran Guo, Xinhang Tan, Achen Zhao, Xinghua Lian, Huiling Dai, Shaozhuang Li, Kexu Xin, Changfu Tian, Jun Yang, Wansheng Chen, Alberto P. Macho, Ertao Wang
Legume roots secure nitrogen by forming a symbiosis with soil rhizobia but remain resistant to pathogenic bacteria1-4. How this tolerance to rhizobia is achieved without compromising plant immunity is largely unknown. Here, we identify the cytoplasmic kinase MtLICK1/2, which interacts with nodulation factor receptor MtLYK3 to drive symbiotic signaling and suppress plant immunity. Rhizobial infection
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Molecular basis of SIFI activity in the integrated stress response Nature (IF 50.5) Pub Date : 2025-05-06 Zhi Yang, Diane L. Haakonsen, Michael Heider, Samuel R. Witus, Alex Zelter, Tobias Beschauner, Michael J. MacCoss, Michael Rapé
Chronic stress response activation impairs cell survival and causes devastating degenerative di-seases 1-3. Organisms accordingly deploy silencing factors, such as the E3 ubiquitin ligase SIFI, to terminate stress response signaling and ensure cellular homeostasis 4. How a silencing factor can sense stress across cellular scales to elicit timely stress response inactivation is poorly understood. Here
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Naturally ornate RNA-only complexes revealed by cryo-EM Nature (IF 50.5) Pub Date : 2025-05-06 Rachael C. Kretsch, Yuan Wu, Svetlana A. Shabalina, Hyunbin Lee, Grace Nye, Eugene V. Koonin, Alex Gao, Wah Chiu, Rhiju Das
Myriad families of natural RNAs have been proposed, but not yet experimentally shown, to form biologically important structures1–4. Here we report three-dimensional structures of three large ornate bacterial RNAs using cryogenic electron microscopy at resolutions of 2.9-3.1 Å. Without precedent among previously characterized natural RNA molecules, Giant, Ornate, Lake- and Lactobacillales-Derived (GOLLD)
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A DNA-gated molecular guard controls bacterial Hailong anti-phage defence Nature (IF 50.5) Pub Date : 2025-04-30 Joel M. J. Tan, Sarah Melamed, Joshua C. Cofsky, Deepsing Syangtan, Samuel J. Hobbs, Josefina Del Marmol, Marco Jost, Andrew C. Kruse, Rotem Sorek, Philip J. Kranzusch
Animal and bacterial cells use nucleotidyltransferase (NTase) enzymes to respond to viral infection and control major forms of immune signaling including cGAS-STING innate immunity and CBASS anti-phage defence1-4. Here we discover a family of bacterial defence systems, which we name Hailong, that use NTase enzymes to constitutively synthesize DNA signals and guard against phage infection. Hailong protein
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A MERS-CoV-like mink coronavirus uses ACE2 as entry receptor Nature (IF 50.5) Pub Date : 2025-04-30 Ningning Wang, Weiwei Ji, Houqi Jiao, Michael Veit, Ju Sun, Yanjun Wang, Xing Ma, Yu Wang, Yutong Wang, Xin-xin Li, Xiaoguang Zhang, Jie Chen, Jiayu Wei, Ying Xu, Dawei Guo, Xiaofeng Zhai, Andres Merits, Chang Li, Félix A. Rey, Georgi M. Dobrikov, George F. Gao, Shuijun Zhang, Yuhai Bi, Shuo Su
Despite accumulating evidence that bat-derived coronaviruses often require intermediate hosts to facilitate transmission to humans1, the potential role of fur animals in zoonotic coronavirus spillovers has largely been overlooked2. Here we report the isolation and characterization of a novel mink respiratory coronavirus (MRCoV) from farmed minks with pneumonia. Notably, MRCoV uses angiotensin-converting
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Metal-centred planar [15]annulenes Nature (IF 50.5) Pub Date : 2025-04-30 Binbin Xu, Dafa Chen, Kaidong Ruan, Ming Luo, Yuanting Cai, Jia Qiu, Wenhao Zhou, Bula Cao, Zhenyang Lin, Jonathan L. Sessler, Haiping Xia
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Adversarial testing of global neuronal workspace and integrated information theories of consciousness Nature (IF 50.5) Pub Date : 2025-04-30 Oscar Ferrante, Urszula Gorska-Klimowska, Simon Henin, Rony Hirschhorn, Aya Khalaf, Alex Lepauvre, Ling Liu, David Richter, Yamil Vidal, Niccolò Bonacchi, Tanya Brown, Praveen Sripad, Marcelo Armendariz, Katarina Bendtz, Tara Ghafari, Dorottya Hetenyi, Jay Jeschke, Csaba Kozma, David R. Mazumder, Stephanie Montenegro, Alia Seedat, Abdelrahman Sharafeldin, Shujun Yang, Sylvain Baillet, David J. Chalmers
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Diet outperforms microbial transplant to drive microbiome recovery in mice Nature (IF 50.5) Pub Date : 2025-04-30 M. S. Kennedy, A. Freiburger, M. Cooper, K. Beilsmith, M. L. St George, M. Kalski, C. Cham, A. Guzzetta, S. C. Ng, F. K. Chan, O. DeLeon, D. Rubin, C. S. Henry, J. Bergelson, E. B. Chang
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TIR domains produce histidine-ADPR as an immune signal in bacteria Nature (IF 50.5) Pub Date : 2025-04-30 Dziugas Sabonis, Carmel Avraham, Renee B. Chang, Allen Lu, Ehud Herbst, Arunas Silanskas, Deividas Vilutis, Azita Leavitt, Erez Yirmiya, Hunter C. Toyoda, Audrone Ruksenaite, Mindaugas Zaremba, Ilya Osterman, Gil Amitai, Philip J. Kranzusch, Rotem Sorek, Giedre Tamulaitiene