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‘Talking won’t save the planet’: uniting efforts to save Panama’s parks Nature (IF 50.5) Pub Date : 2025-02-17
Juan Carlos Navarro shares his hopes and frustrations as he works to protect his country’s biodiversity and fight climate change.
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Here’s how to bag a hefty research prize to turbocharge innovation Nature (IF 50.5) Pub Date : 2025-02-17
‘Challenge’ prizes are growing in popularity, but stimulating creativity takes more than financial incentives.
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Researchers overlooked airborne diseases for centuries — then COVID-19 changed everything Nature (IF 50.5) Pub Date : 2025-02-17
A fascinating exploration of microbes that can travel through the air reveals how the pandemic marked a turning point for a crucial research field.
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Money and murder: the dark side of the Asilomar meeting on recombinant DNA Nature (IF 50.5) Pub Date : 2025-02-17
The famed 1975 conference about a controversial genetic technology is feted as an example of how scientific self-regulation works. But more significant is what wasn’t discussed.
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What are the best AI tools for research? Nature’s guide Nature (IF 50.5) Pub Date : 2025-02-17
There are many large language models to choose from; some excel at coding, whereas others are better for synthesizing information.
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Daily briefing: Scientists use AI to design life-like enzymes from scratch Nature (IF 50.5) Pub Date : 2025-02-14
What Robert F. Kennedy Jr might do with his newfound influence over US science. Plus, life-like enzymes designed from scratch can accelerate a four-step reaction.
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Comprehensive single-cell analysis deciphered the immunoregulatory mechanism of TPPU in alleviating sepsis-related acute liver injury J. Adv. Res. (IF 11.4) Pub Date : 2025-02-15 Juan Li, Mengjuan Xuan, Li Yang, Yingru Liu, Na Lou, Leiya Fu, Qingmiao Shi, Chen Xue
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In This Issue Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2025-02-11
Proceedings of the National Academy of Sciences, Volume 122, Issue 6, February 2025.
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NASA embraced diversity. Trump’s DEI purge is hitting space scientists hard Nature (IF 50.5) Pub Date : 2025-02-14
Some researchers at NASA and outside it feel betrayed by the changes at the agency, which was known for promoting inclusion in science.
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‘Targeted and belittled’: scientists at US environmental agency speak out as layoffs begin Nature (IF 50.5) Pub Date : 2025-02-14
President Donald Trump and his team view the Environmental Protection Agency as a threat to US prosperity. Workers have been waiting for the axe to fall.
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Daily briefing: Why US scientists aren’t retiring Nature (IF 50.5) Pub Date : 2025-02-12
Centuries of isolation shaped Greenlanders’ unique genetics. Plus, why so many US scientists don’t want to retire.
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Specific Macronutrient clusters associated with lower mortality Risk: Evidence from NHANES 1999–2018 J. Adv. Res. (IF 11.4) Pub Date : 2025-02-14 Jiaying Yu, Yang Chen, Defang Li, Lan Zhang, Yuting Zhang, Jiaqi Zhang, Jiayu Zhu, Zican Li, Hongxin Fu, Dongwei Guan, Runan Zhang, Liyan Liu, Cheng Wang, Changhao Sun, Rennan Feng
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‘Researching climate change feels like standing in the path of an approaching train’ Nature (IF 50.5) Pub Date : 2025-02-14
Studying the impacts of extreme weather events can exact a heavy mental toll. Finding your ‘happy place’ is an important coping strategy.
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Why I retracted part of my PhD dissertation Nature (IF 50.5) Pub Date : 2025-02-14
Psychologist Laura Steenbergen took the step after raising research-integrity concerns about a former mentor.
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Bats on film: scientific storytelling from a recovering academic Nature (IF 50.5) Pub Date : 2025-02-14
Scientific exchange is more than just research papers. Get your camera out to capture the beauty and intensity of your work, says Mariëtte van der Walt.
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Bullseye! Galaxy hosts a record-breaking nine starry rings Nature (IF 50.5) Pub Date : 2025-02-13
Astronomers trace the striking pattern to an encounter between a big galaxy and a much smaller one some 50 million years ago.
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From farm to pharmacy: gene-edited plants produce a popular supplement Nature (IF 50.5) Pub Date : 2025-02-13
Widely grown crops can be bioengineered to make a form of coenzyme Q taken by people seeking a health boost.
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Daily briefing: A simple blood test could diagnose pancreatic cancer early Nature (IF 50.5) Pub Date : 2025-02-13
A new blood test could diagnose pancreatic cancer before it spreads. Plus, physicists have detected the highest-energy neutrino ever.
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Scientists use AI to design life-like enzymes from scratch Nature (IF 50.5) Pub Date : 2025-02-13
Combined approach takes AI-engineered enzymes one step closer to practical applications.
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Royal Society will meet amid campaign to revoke Elon Musk’s fellowship Nature (IF 50.5) Pub Date : 2025-02-13
More than 1,300 scientists have signed a letter calling on the world’s oldest science society to reassess the billionaire’s membership following cuts to US science.
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Vaccine sceptic RFK Jr is now a powerful force in US science: what will he do? Nature (IF 50.5) Pub Date : 2025-02-13
Kennedy has expressed support for some fields, but has also declared he’d like a ‘break’ in infectious-disease research.
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Quantum-computing technology that makes qubits from atoms wins mega investment Nature (IF 50.5) Pub Date : 2025-02-13
Firms using ‘neutral atoms’ to create qubits are reentering the race to build useful quantum machines.
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Receptor clustering tunes and sharpens the selectivity of multivalent binding Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2025-02-14 Zhaoping Xie, Stefano Angioletti-Uberti, Jure Dobnikar, Daan Frenkel, Tine Curk
The immune system exploits a wide range of strategies to combine sensitivity with selectivity for optimal response. We propose a generic physical mechanism that allows tuning the location and steepness of the response threshold of cellular processes activated by multivalent binding. The mechanism is based on the possibility to modulate the attraction between membrane receptors. We use theory and simulations
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Bioinspired energy-free temperature gradient regulator for significant enhancement of thermoelectric conversion efficiency Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2025-02-14 Haohan Tan, Yuqian Zhao, Peng Jin, Xiang Xu, Xinchen Zhou, Fabio Marchesoni, Jiping Huang
Enhancing thermoelectric conversion efficiency (TCE) is pivotal for advancing global energy conservation and emission reduction initiatives. Traditional approaches primarily focus on microscopic strategies such as bandgap engineering, chemical potential adjustments, and entropy engineering. However, these methods face substantial limitations in practical applications due to challenging material property
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Detrimental influence of Arginase-1 in infiltrating macrophages on poststroke functional recovery and inflammatory milieu Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2025-02-14 Hyung Soon Kim, Seung Ah Jee, Ariandokht Einisadr, Yeojin Seo, Hyo Gyeong Seo, Byeong Seong Jang, Hee Hwan Park, Won-Suk Chung, Byung Gon Kim
Poststroke inflammation critically influences functional outcomes following ischemic stroke. Arginase-1 (Arg1) is considered a marker for anti-inflammatory macrophages, associated with the resolution of inflammation and promotion of tissue repair in various pathological conditions. However, its specific role in poststroke recovery remains to be elucidated. This study investigates the functional impact
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Structures and functions of the limited natural polyclonal antibody response to parvovirus infection Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2025-02-14 Oluwafemi F. Adu, Hyunwook Lee, Simon P. Früh, Marta V. Schoenle, Wendy S. Weichert, Andrew I. Flyak, Susan L. Hafenstein, Colin R. Parrish
Host antibody responses are key components in the protection of animals against pathogens, yet the defining properties of viral antigens and induction of B cell responses that result in varied protection are still poorly understood. Parvoviruses are simple molecular structures that display 60 repeated motifs on their capsid surface, and rapidly induce strong antibody responses that protect animals
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Fast Interpretable Greedy-Tree Sums Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2025-02-14 Yan Shuo Tan, Chandan Singh, Keyan Nasseri, Abhineet Agarwal, James Duncan, Omer Ronen, Matthew Epland, Aaron Kornblith, Bin Yu
Modern machine learning has achieved impressive prediction performance, but often sacrifices interpretability, a critical consideration in high-stakes domains such as medicine. In such settings, practitioners often use highly interpretable decision tree models, but these suffer from inductive bias against additive structure. To overcome this bias, we propose Fast Interpretable Greedy-Tree Sums (FIGS)
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Turbulent mixing controls fixation of growing antagonistic populations Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2025-02-14 Jonathan Bauermann, Roberto Benzi, David R. Nelson, Suraj Shankar, Federico Toschi
Unlike coffee and cream that homogenize when stirred, growing micro-organisms (e.g., bacteria, baker’s yeast) can actively kill each other and avoid mixing. How do such antagonistic interactions impact the growth and survival of competing strains, while being spatially advected by turbulent flows? By using numerical simulations of a continuum model, we study the dynamics of two antagonistic strains
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Self-assembled proteomimetic (SAP) with antibody-like binding from short PNA–peptide conjugates Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2025-02-14 Benjamin Brennecke, Beatrice Civili, Pramod M. Sabale, Sofia Barluenga, Benjamin Meyer, Nicolas Winssinger
Affinity proteins based on a three-helix bundle (affibodies, alphabodies, and computationally de novo designed ones) have been shown to be a general platform to discover binders with properties reminiscent of antibodies, combining high target specificity with affinities reaching well below the nanomolar. Herein, we report a strategy, coined self-assembled proteomimetic (SAP), to mimic such three-helix
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Superfluid weight cross-over and critical temperature enhancement in singular flat bands Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2025-02-14 Guodong Jiang, Päivi Törmä, Yafis Barlas
Nonanalytic Bloch eigenstates at isolated band degeneracy points exhibit singular behavior in the quantum metric. Here, a description of superfluid weight for zero-energy flat bands in proximity to other high-energy bands is presented, where they together form a singular band gap system. When the singular band gap closes, the geometric and conventional contributions to the superfluid weight as a function
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Hypothalamic opsin 3 suppresses MC4R signaling and potentiates Kir7.1 to promote food consumption Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2025-02-14 Hala K. Haddad, Jonathan I. Mercado-Reyes, E. Román Mustafá, Shane P. D’Souza, C. Sean Chung, Ramses R. M. Nestor, Lauren E. Olinski, Valentina Martinez Damonte, Joshua Saskin, Shruti Vemaraju, Jesica Raingo, Julie A. Kauer, Richard A. Lang, Elena Oancea
Mammalian opsin 3 (OPN3) is a member of the opsin family of G-protein-coupled receptors with ambiguous light sensitivity. OPN3 was first identified in the brain (and named encephalopsin) and subsequently found to be expressed in other tissues. In adipocytes, OPN3 is necessary for light responses that modulate lipolysis and glucose uptake, while OPN3 in human skin melanocytes regulates pigmentation
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Variable-strength nonlocal measurements reveal quantum violations of classical counting principles Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2025-02-14 Noah Lupu-Gladstein, Ou Teen Arthur Pang, Hugo Ferretti, Weng-Kian Tham, Aephraim M. Steinberg, Kent Bonsma-Fisher, Aharon Brodutch
We implement a variant of the quantum pigeonhole paradox thought experiment to study whether classical counting principles survive in the quantum domain. We observe strong measurements significantly violate the pigeonhole principle (that among three pigeons in two holes, at least one pair must be in the same hole) and the sum rule (that the number of pigeon pairs in the same hole is the sum of the
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AI protocol for retrieving protein dynamic structures from two-dimensional infrared spectra Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2025-02-14 Sheng Ye, Lvshuai Zhu, Zhicheng Zhao, Fan Wu, Zhipeng Li, BinBin Wang, Kai Zhong, Changyin Sun, Shaul Mukamel, Jun Jiang
Understanding the dynamic evolution of protein structures is crucial for uncovering their biological functions. Yet, real-time prediction of these dynamic structures remains a significant challenge. Two-dimensional infrared (2DIR) spectroscopy is a powerful tool for analyzing protein dynamics. However, translating its complex, low-dimensional signals into detailed three-dimensional structures is a
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A method for unsupervised learning of coherent spatiotemporal patterns in multiscale data Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2025-02-14 Karl Lapo, Sara M. Ichinaga, J. Nathan Kutz
The unsupervised and principled diagnosis of multiscale data is a fundamental obstacle in modern scientific problems from, for instance, weather and climate prediction, neurology, epidemiology, and turbulence. Multiscale data are characterized by a combination of processes acting along multiple dimensions simultaneously, spatiotemporal scales across orders of magnitude, nonstationarity, and/or invariances
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A dual absorption pathway of novel oyster-derived peptide-zinc complex enhances zinc bioavailability and restores mitochondrial function J. Adv. Res. (IF 11.4) Pub Date : 2025-02-13 Ximing Yang, Siyi Wang, Hanxiong Liu, Tuo Zhang, Shuzhen Cheng, Ming Du
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Mebendazole induces ZBP-1 mediated PANoptosis of acute myeloid leukemia cells by targeting TUBA1A and exerts antileukemia effect J. Adv. Res. (IF 11.4) Pub Date : 2025-02-12 Wei Yang, Ying Xu, Shuai Liu, Lin Gao, Shi Li, Xina Xie, Qiaoxia Zhang, Obaid Habib, Ronglin Chen, Xiongfei Sun, Zesong Li
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Author Correction: India–Eurasia convergence speed-up by passive-margin sediment subduction Nature (IF 50.5) Pub Date : 2025-02-13 Hao Zhou, Jiashun Hu, Luca Dal Zilio, Ming Tang, Keqing Li, Xiumian Hu
Correction to: Nature https://doi.org/10.1038/s41586-024-08069-6 Published online 6 November 2024
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Publisher Correction: Immune evasion through mitochondrial transfer in the tumour microenvironment Nature (IF 50.5) Pub Date : 2025-02-13 Hideki Ikeda, Katsushige Kawase, Tatsuya Nishi, Tomofumi Watanabe, Keizo Takenaga, Takashi Inozume, Takamasa Ishino, Sho Aki, Jason Lin, Shusuke Kawashima, Joji Nagasaki, Youki Ueda, Shinichiro Suzuki, Hideki Makinoshima, Makiko Itami, Yuki Nakamura, Yasutoshi Tatsumi, Yusuke Suenaga, Takao Morinaga, Akiko Honobe-Tabuchi, Takehiro Ohnuma, Tatsuyoshi Kawamura, Yoshiyasu Umeda, Yasuhiro Nakamura, Yukiko
Correction to: Nature https://doi.org/10.1038/s41586-024-08439-0 Published online 22 January 2025
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Are the Trump team’s actions affecting your research? How to contact Nature Nature (IF 50.5) Pub Date : 2025-02-13
Use this form to share information with Nature’s news team, or to make suggestions for future coverage.
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Are PhDs losing their lustre? Why fewer students are enrolling in doctoral degrees Nature (IF 50.5) Pub Date : 2025-02-13
High living costs paired with stagnant stipends are being blamed for a drop in PhD enrolments in several countries.
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The researchers on a quest to protect the gut from antibiotics Nature (IF 50.5) Pub Date : 2025-02-13
The crucial drugs can have unintended consequences. Innovative therapies could shield the microbiome from their effects.
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σ-Bond insertion reactions of two strained diradicaloids Nature (IF 50.5) Pub Date : 2025-02-12 Arismel Tena Meza, Christina A. Rivera, Huiling Shao, Andrew V. Kelleghan, K. N. Houk, Neil K. Garg
The development of new synthetic methodologies are instrumental for enabling the discovery of new medicines. Those methods that provide efficient access to structural alternatives for aromatic compounds (i.e., saturated arene bioisosteres), have become highly coveted.1,2,3,4 The incorporation of such bioisosteres typically leads to favorable drug-like properties and represents an emerging field of
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Observation of Plastic Ice VII by Quasi-Elastic Neutron Scattering Nature (IF 50.5) Pub Date : 2025-02-12 Maria Rescigno, Alberto Toffano, Umbertoluca Ranieri, Leon Andriambariarijaona, Richard Gaal, Stefan Klotz, Michael Marek Koza, Jacques Ollivier, Fausto Martelli, John Russo, Francesco Sciortino, Jose Teixeira, Livia Eleonora Bove
Water is the third most abundant molecule in the universe and a key component in the interiors of icy moons, giant planets, and Uranus- and Neptune-like exoplanets1–3. Owing to its distinct molecular structure and flexible hydrogen bonds that readily adapt to a wide range of pressures and temperatures, water forms numerous crystalline and amorphous phases4–6. Most relevant for the high pressures and
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Cheap blood test detects pancreatic cancer before it spreads Nature (IF 50.5) Pub Date : 2025-02-12
The deadly cancer is often not found until it has spread to other parts of the body.
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Gourmet cockatoos like to fancy up their food Nature (IF 50.5) Pub Date : 2025-02-12
Make mine blueberry: Goffin’s cockatoos add flair to plain vegetables with a dip into fruity soy yogurt.
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Observation of an ultra-high-energy cosmic neutrino with KM3NeT Nature (IF 50.5) Pub Date : 2025-02-12
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Learning produces an orthogonalized state machine in the hippocampus Nature (IF 50.5) Pub Date : 2025-02-12 Weinan Sun, Johan Winnubst, Maanasa Natrajan, Chongxi Lai, Koichiro Kajikawa, Arco Bast, Michalis Michaelos, Rachel Gattoni, Carsen Stringer, Daniel Flickinger, James E. Fitzgerald, Nelson Spruston
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Transcriptional adaptation upregulates utrophin in Duchenne muscular dystrophy Nature (IF 50.5) Pub Date : 2025-02-12 Lara Falcucci, Christopher M. Dooley, Douglas Adamoski, Thomas Juan, Justin Martinez, Angelina M. Georgieva, Kamel Mamchaoui, Cansu Cirzi, Didier Y. R. Stainier
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Transcriptomic neuron types vary topographically in function and morphology Nature (IF 50.5) Pub Date : 2025-02-12 Inbal Shainer, Johannes M. Kappel, Eva Laurell, Joseph C. Donovan, Martin W. Schneider, Enrico Kuehn, Irene Arnold-Ammer, Manuel Stemmer, Johannes Larsch, Herwig Baier
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Topological segregation of stress sensors along the gut crypt–villus axis Nature (IF 50.5) Pub Date : 2025-02-12 Kouki K. Touhara, Nathan D. Rossen, Fei Deng, Joel Castro, Andrea M. Harrington, Tifany Chu, Sonia Garcia-Caraballo, Mariana Brizuela, Tracey O’Donnell, Jinhao Xu, Onur Cil, Stuart M. Brierley, Yulong Li, David Julius
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A metagenomic ‘dark matter’ enzyme catalyses oxidative cellulose conversion Nature (IF 50.5) Pub Date : 2025-02-12 Clelton A. Santos, Mariana A. B. Morais, Fernanda Mandelli, Evandro A. Lima, Renan Y. Miyamoto, Paula M. R. Higasi, Evandro A. Araujo, Douglas A. A. Paixão, Joaquim M. Junior, Maria L. Motta, Rodrigo S. A. Streit, Luana G. Morão, Claudio B. C. Silva, Lucia D. Wolf, Cesar R. F. Terrasan, Nathalia R. Bulka, Jose A. Diogo, Felipe J. Fuzita, Felippe M. Colombari, Camila R. Santos, Priscila T. Rodrigues
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UM171 glues asymmetric CRL3–HDAC1/2 assembly to degrade CoREST corepressors Nature (IF 50.5) Pub Date : 2025-02-12 Megan J. R. Yeo, Olivia Zhang, Xiaowen Xie, Eunju Nam, N. Connor Payne, Pallavi M. Gosavi, Hui Si Kwok, Irtiza Iram, Ceejay Lee, Jiaming Li, Nicholas J. Chen, Khanh Nguyen, Hanjie Jiang, Zhipeng A. Wang, Kwangwoon Lee, Haibin Mao, Stefan A. Harry, Idris A. Barakat, Mariko Takahashi, Amanda L. Waterbury, Marco Barone, Andrea Mattevi, Steven A. Carr, Namrata D. Udeshi, Liron Bar-Peled, Philip A. Cole
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Global engineering effects of soil invertebrates on ecosystem functions Nature (IF 50.5) Pub Date : 2025-02-12 Donghao Wu, Enzai Du, Nico Eisenhauer, Jérome Mathieu, Chengjin Chu
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Genetic architecture in Greenland is shaped by demography, structure and selection Nature (IF 50.5) Pub Date : 2025-02-12 Frederik Filip Stæger, Mette K. Andersen, Zilong Li, Jasmin Pernille Hjerresen, Shixu He, Cindy G. Santander, Rasmus Tanderup Jensen, Karsten Fleischer Rex, Anne Cathrine Baun Thuesen, Kristian Hanghøj, Inge Høst Seiding, Emil Jørsboe, Sara Elizabeth Stinson, Malthe Sebro Rasmussen, Renzo F. Balboa, Christina Viskum Lytken Larsen, Peter Bjerregaard, Mikkel Schubert, Jonas Meisner, Allan Linneberg,
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Macrophages protect against sensory axon loss in peripheral neuropathy Nature (IF 50.5) Pub Date : 2025-02-12 Sara Hakim, Aakanksha Jain, Stuart S. Adamson, Veselina Petrova, Jonathan Indajang, Hyoung Woo Kim, Riki Kawaguchi, Qing Wang, Elif S. Duran, Drew Nelson, Caitlin A. Greene, Jenae Rasmussen, Clifford J. Woolf