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GTSF1 accelerates target RNA cleavage by PIWI-clade Argonaute proteins Nature (IF 69.504) Pub Date : 2022-06-30 Amena Arif, Shannon Bailey, Natsuko Izumi, Todd A. Anzelon, Deniz M. Ozata, Cecilia Andersson, Ildar Gainetdinov, Ian J. MacRae, Yukihide Tomari, Phillip D. Zamore
Argonaute proteins use nucleic acid guides to find and bind specific DNA or RNA target sequences. Argonaute proteins can be found in all kingdoms of life, and play diverse biological functions including genome defense, gene regulation, and chromosome partitioning. Many Argonautes retain their ancestral endoribonuclease activity, cleaving the phosphodiester bond between target nucleotides t10 and t11
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Surface-to-space atmospheric waves from Hunga Tonga-Hunga Ha’apai eruption Nature (IF 69.504) Pub Date : 2022-06-30 Corwin J. Wright, Neil P. Hindley, M. Joan Alexander, Mathew Barlow, Lars Hoffmann, Cathryn N. Mitchell, Fred Prata, Marie Bouillon, Justin Carstens, Cathy Clerbaux, Scott M. Osprey, Nick Powell, Cora E. Randall, Jia Yue
The January 2022 Hunga Tonga–Hunga Haʻapai eruption was one of the most explosive volcanic events of the modern era1,2, producing a vertical plume which peaked > 50km above the Earth3. The initial explosion and subsequent plume triggered atmospheric waves which propagated around the world multiple times4. A global-scale wave response of this magnitude from a single source has not previously been observed
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Scalable single-mode surface emitting laser via open-Dirac singularities Nature (IF 69.504) Pub Date : 2022-06-29 Rushin Contractor, Wanwoo Noh, Walid Redjem, Wayesh Qarony, Emma Martin, Scott Dhuey, Adam Schwartzberg, Boubacar Kanté
Single-aperture cavities are a key component of lasers, instrumental for the amplification and emission of a single light mode. However, the appearance of high-order transverse modes as cavities size increases has frustrated efforts to scale up cavities whilst preserving single-mode operation since the invention of the laser six decades ago1-8. A suitable physical mechanism that allows single-mode
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Optimization of avian perching manoeuvres Nature (IF 69.504) Pub Date : 2022-06-29 Marco KleinHeerenbrink, Lydia A. France, Caroline H. Brighton, Graham K. Taylor
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Structural basis for SHOC2 modulation of RAS signalling Nature (IF 69.504) Pub Date : 2022-06-29 Nicholas P. D. Liau, Matthew C. Johnson, Saeed Izadi, Luca Gerosa, Michal Hammel, John M. Bruning, Timothy J. Wendorff, Wilson Phung, Sarah G. Hymowitz, Jawahar Sudhamsu
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Hypocrystalline ceramic aerogels for thermal insulation at extreme conditions Nature (IF 69.504) Pub Date : 2022-06-29 Jingran Guo, Shubin Fu, Yuanpeng Deng, Xiang Xu, Shujin Laima, Dizhou Liu, Pengyu Zhang, Jian Zhou, Han Zhao, Hongxuan Yu, Shixuan Dang, Jianing Zhang, Yingde Zhao, Hui Li, Xiangfeng Duan
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Structural insights into dsRNA processing by Drosophila Dicer-2–Loqs-PD Nature (IF 69.504) Pub Date : 2022-06-29 Shichen Su, Jia Wang, Ting Deng, Xun Yuan, Jinqiu He, Nan Liu, Xiaomin Li, Ying Huang, Hong-Wei Wang, Jinbiao Ma
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Structures and mechanism of the plant PIN-FORMED auxin transporter Nature (IF 69.504) Pub Date : 2022-06-29 Kien Lam Ung, Mikael Winkler, Lukas Schulz, Martina Kolb, Dorina P. Janacek, Emil Dedic, David L. Stokes, Ulrich Z. Hammes, Bjørn Panyella Pedersen
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GREM1 is required to maintain cellular heterogeneity in pancreatic cancer Nature (IF 69.504) Pub Date : 2022-06-29 Linxiang Lan, Theodore Evan, Huafu Li, Aasia Hussain, E. Josue Ruiz, May Zaw Thin, Rute M. M. Ferreira, Hari Ps, Eva M. Riising, Yoh Zen, Jorge Almagro, Kevin W. Ng, Pablo Soro-Barrio, Jessica Nelson, Gabriela Koifman, Joana Carvalho, Emma L. Nye, Yulong He, Changhua Zhang, Anguraj Sadanandam, Axel Behrens
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Grey wolf genomic history reveals a dual ancestry of dogs Nature (IF 69.504) Pub Date : 2022-06-29 Anders Bergström, David W. G. Stanton, Ulrike H. Taron, Laurent Frantz, Mikkel-Holger S. Sinding, Erik Ersmark, Saskia Pfrengle, Molly Cassatt-Johnstone, Ophélie Lebrasseur, Linus Girdland-Flink, Daniel M. Fernandes, Morgane Ollivier, Leo Speidel, Shyam Gopalakrishnan, Michael V. Westbury, Jazmin Ramos-Madrigal, Tatiana R. Feuerborn, Ella Reiter, Joscha Gretzinger, Susanne C. Münzel, Pooja Swali, Nicholas
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Enteric viruses replicate in salivary glands and infect through saliva Nature (IF 69.504) Pub Date : 2022-06-29 S. Ghosh, M. Kumar, M. Santiana, A. Mishra, M. Zhang, H. Labayo, A. M. Chibly, H. Nakamura, T. Tanaka, W. Henderson, E. Lewis, O. Voss, Y. Su, Y. Belkaid, J. A. Chiorini, M. P. Hoffman, N. Altan-Bonnet
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Increasing the resilience of plant immunity to a warming climate Nature (IF 69.504) Pub Date : 2022-06-29 Jong Hum Kim, Christian Danve M. Castroverde, Shuai Huang, Chao Li, Richard Hilleary, Adam Seroka, Reza Sohrabi, Diana Medina-Yerena, Bethany Huot, Jie Wang, Kinya Nomura, Sharon K. Marr, Mary C. Wildermuth, Tao Chen, John D. MacMicking, Sheng Yang He
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Chiral molecular intercalation superlattices Nature (IF 69.504) Pub Date : 2022-06-29 Qi Qian, Huaying Ren, Jingyuan Zhou, Zhong Wan, Jingxuan Zhou, Xingxu Yan, Jin Cai, Peiqi Wang, Bailing Li, Zdenek Sofer, Bo Li, Xidong Duan, Xiaoqing Pan, Yu Huang, Xiangfeng Duan
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Mitochondrial RNA modifications shape metabolic plasticity in metastasis Nature (IF 69.504) Pub Date : 2022-06-29 Sylvain Delaunay, Gloria Pascual, Bohai Feng, Kevin Klann, Mikaela Behm, Agnes Hotz-Wagenblatt, Karsten Richter, Karim Zaoui, Esther Herpel, Christian Münch, Sabine Dietmann, Jochen Hess, Salvador Aznar Benitah, Michaela Frye
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YAP/TAZ activity in stromal cells prevents ageing by controlling cGAS–STING Nature (IF 69.504) Pub Date : 2022-06-29 Hanna Lucie Sladitschek-Martens, Alberto Guarnieri, Giulia Brumana, Francesca Zanconato, Giusy Battilana, Romy Lucon Xiccato, Tito Panciera, Mattia Forcato, Silvio Bicciato, Vincenza Guzzardo, Matteo Fassan, Lorenzo Ulliana, Alessandro Gandin, Claudio Tripodo, Marco Foiani, Giovanna Brusatin, Michelangelo Cordenonsi, Stefano Piccolo
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A peroxisomal ubiquitin ligase complex forms a retrotranslocation channel Nature (IF 69.504) Pub Date : 2022-06-29 Peiqiang Feng, Xudong Wu, Satchal K. Erramilli, Joao A. Paulo, Pawel Knejski, Steven P. Gygi, Anthony A. Kossiakoff, Tom A. Rapoport
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Structure of the Dicer-2–R2D2 heterodimer bound to a small RNA duplex Nature (IF 69.504) Pub Date : 2022-06-29 Sonomi Yamaguchi, Masahiro Naganuma, Tomohiro Nishizawa, Tsukasa Kusakizako, Yukihide Tomari, Hiroshi Nishimasu, Osamu Nureki
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Integrated multiomic characterization of congenital heart disease Nature (IF 69.504) Pub Date : 2022-06-22 Matthew C. Hill, Zachary A. Kadow, Hali Long, Yuka Morikawa, Thomas J. Martin, Emma J. Birks, Kenneth S. Campbell, Jeanne Nerbonne, Kory Lavine, Lalita Wadhwa, Jun Wang, Diwakar Turaga, Iki Adachi, James F. Martin
The heart, the first organ to develop, undergoes complex morphogenesis that when defective results in congenital heart disease (CHD). With current therapies, more than 90% of CHD patients survive into adulthood but often suffer premature death from heart failure (HF) and non-cardiac causes 1. To gain insight into poorly understood disease progression, we performed single nuclear RNA sequencing (snRNA-seq)
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Women are Credited Less in Science than are Men Nature (IF 69.504) Pub Date : 2022-06-22 Matthew B. Ross, Britta M. Glennon, Raviv Murciano-Goroff, Enrico G. Berkes, Bruce A. Weinberg, Julia I. Lane
There is a well-documented gap in the observed number of scientific works produced by women and men in science, with clear consequences for the retention and promotion of women in science1. The gap might be a result of productivity differences2-5, or it might be due to women’s contributions not being acknowledged6,7. This paper finds that at least part of this gap is due to the latter: women in research
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Engineering topological states in atom-based semiconductor quantum dots Nature (IF 69.504) Pub Date : 2022-06-22 M. Kiczynski, S. K. Gorman, H. Geng, M. B. Donnelly, Y. Chung, Y. He, J. G. Keizer, M. Y. Simmons
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Ablation of cDC2 development by triple mutations within the Zeb2 enhancer Nature (IF 69.504) Pub Date : 2022-06-22 Tian-Tian Liu, Sunkyung Kim, Pritesh Desai, Do-Hyun Kim, Xiao Huang, Stephen T. Ferris, Renee Wu, Feiya Ou, Takeshi Egawa, Steven J. Van Dyken, Michael S. Diamond, Peter F. Johnson, Masato Kubo, Theresa L. Murphy, Kenneth M. Murphy
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Two-dimensional materials prospects for non-volatile spintronic memories Nature (IF 69.504) Pub Date : 2022-06-22 Hyunsoo Yang, Sergio O. Valenzuela, Mairbek Chshiev, Sébastien Couet, Bernard Dieny, Bruno Dlubak, Albert Fert, Kevin Garello, Matthieu Jamet, Dae-Eun Jeong, Kangho Lee, Taeyoung Lee, Marie-Blandine Martin, Gouri Sankar Kar, Pierre Sénéor, Hyeon-Jin Shin, Stephan Roche
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Single-nucleus profiling of human dilated and hypertrophic cardiomyopathy Nature (IF 69.504) Pub Date : 2022-06-22 Mark Chaffin, Irinna Papangeli, Bridget Simonson, Amer-Denis Akkad, Matthew C. Hill, Alessandro Arduini, Stephen J. Fleming, Michelle Melanson, Sikander Hayat, Maria Kost-Alimova, Ondine Atwa, Jiangchuan Ye, Kenneth C. Bedi, Matthias Nahrendorf, Virendar K. Kaushik, Christian M. Stegmann, Kenneth B. Margulies, Nathan R. Tucker, Patrick T. Ellinor
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Biosynthetic potential of the global ocean microbiome Nature (IF 69.504) Pub Date : 2022-06-22 Lucas Paoli, Hans-Joachim Ruscheweyh, Clarissa C. Forneris, Florian Hubrich, Satria Kautsar, Agneya Bhushan, Alessandro Lotti, Quentin Clayssen, Guillem Salazar, Alessio Milanese, Charlotte I. Carlström, Chrysa Papadopoulou, Daniel Gehrig, Mikhail Karasikov, Harun Mustafa, Martin Larralde, Laura M. Carroll, Pablo Sánchez, Ahmed A. Zayed, Dylan R. Cronin, Silvia G. Acinas, Peer Bork, Chris Bowler, Tom
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Asymmetric pore windows in MOF membranes for natural gas valorization Nature (IF 69.504) Pub Date : 2022-06-22 Sheng Zhou, Osama Shekhah, Adrian Ramírez, Pengbo Lyu, Edy Abou-Hamad, Jiangtao Jia, Jiantang Li, Prashant M. Bhatt, Zhiyuan Huang, Hao Jiang, Tian Jin, Guillaume Maurin, Jorge Gascon, Mohamed Eddaoudi
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Life rather than climate influences diversity at scales greater than 40 million years Nature (IF 69.504) Pub Date : 2022-06-22 Andrej Spiridonov, Shaun Lovejoy
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Observation of a correlated free four-neutron system Nature (IF 69.504) Pub Date : 2022-06-22 M. Duer, T. Aumann, R. Gernhäuser, V. Panin, S. Paschalis, D. M. Rossi, N. L. Achouri, D. Ahn, H. Baba, C. A. Bertulani, M. Böhmer, K. Boretzky, C. Caesar, N. Chiga, A. Corsi, D. Cortina-Gil, C. A. Douma, F. Dufter, Z. Elekes, J. Feng, B. Fernández-Domínguez, U. Forsberg, N. Fukuda, I. Gasparic, Z. Ge, J. M. Gheller, J. Gibelin, A. Gillibert, K. I. Hahn, Z. Halász, M. N. Harakeh, A. Hirayama, M. Holl
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eIF5B and eIF1A reorient initiator tRNA to allow ribosomal subunit joining Nature (IF 69.504) Pub Date : 2022-06-22 Christopher P. Lapointe, Rosslyn Grosely, Masaaki Sokabe, Carlos Alvarado, Jinfan Wang, Elizabeth Montabana, Nancy Villa, Byung-Sik Shin, Thomas E. Dever, Christopher S. Fraser, Israel S. Fernández, Joseph D. Puglisi
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cBAF complex components and MYC cooperate early in CD8+ T cell fate Nature (IF 69.504) Pub Date : 2022-06-22 Ao Guo, Hongling Huang, Zhexin Zhu, Mark J. Chen, Hao Shi, Sujing Yuan, Piyush Sharma, Jon P. Connelly, Swantje Liedmann, Yogesh Dhungana, Zhenrui Li, Dalia Haydar, Mao Yang, Helen Beere, Jason T. Yustein, Christopher DeRenzo, Shondra M. Pruett-Miller, Jeremy Chase Crawford, Giedre Krenciute, Charles W. M. Roberts, Hongbo Chi, Douglas R. Green
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PIEZO1 transduces mechanical itch in mice Nature (IF 69.504) Pub Date : 2022-06-22 Rose Z. Hill, Meaghan C. Loud, Adrienne E. Dubin, Brooke Peet, Ardem Patapoutian
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Organic bipolar transistors Nature (IF 69.504) Pub Date : 2022-06-22 Shu-Jen Wang, Michael Sawatzki, Ghader Darbandy, Felix Talnack, Jörn Vahland, Marc Malfois, Alexander Kloes, Stefan Mannsfeld, Hans Kleemann, Karl Leo
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The gut metabolite indole-3 propionate promotes nerve regeneration and repair Nature (IF 69.504) Pub Date : 2022-06-22 Elisabeth Serger, Lucia Luengo-Gutierrez, Jessica S. Chadwick, Guiping Kong, Luming Zhou, Greg Crawford, Matt C. Danzi, Antonis Myridakis, Alexander Brandis, Adesola Temitope Bello, Franziska Müller, Alexandros Sanchez-Vassopoulos, Francesco De Virgiliis, Phoebe Liddell, Marc Emmanuel Dumas, Jessica Strid, Sridhar Mani, Dylan Dodd, Simone Di Giovanni
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Clonally expanded CD8 T cells characterize amyotrophic lateral sclerosis-4 Nature (IF 69.504) Pub Date : 2022-06-22 Laura Campisi, Shahab Chizari, Jessica S. Y. Ho, Anastasia Gromova, Frederic Arnold, Lorena Mosca, Xueyan Mei, Yesai Fstkchyan, Denis Torre, Cindy Beharry, Marta Garcia-Forn, Miguel Jiménez-Alcázar, Vladislav A. Korobeynikov, Jack Prazich, Zahi A. Fayad, Marcus M. Seldin, Silvia De Rubeis, Craig L. Bennett, Lyle W. Ostrow, Christian Lunetta, Massimo Squatrito, Minji Byun, Neil A. Shneider, Ning Jiang
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De novo design of discrete, stable 310-helix peptide assemblies Nature (IF 69.504) Pub Date : 2022-06-22 Prasun Kumar, Neil G. Paterson, Jonathan Clayden, Derek N. Woolfson
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The metastatic spread of breast cancer accelerates during sleep Nature (IF 69.504) Pub Date : 2022-06-22 Zoi Diamantopoulou, Francesc Castro-Giner, Fabienne Dominique Schwab, Christiane Foerster, Massimo Saini, Selina Budinjas, Karin Strittmatter, Ilona Krol, Bettina Seifert, Viola Heinzelmann-Schwarz, Christian Kurzeder, Christoph Rochlitz, Marcus Vetter, Walter Paul Weber, Nicola Aceto
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Many-body theory of positron binding to polyatomic molecules Nature (IF 69.504) Pub Date : 2022-06-22 Jaroslav Hofierka, Brian Cunningham, Charlie M. Rawlins, Charles H. Patterson, Dermot G. Green
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Hadean isotopic fractionation of xenon retained in deep silicates Nature (IF 69.504) Pub Date : 2022-06-22 Igor Rzeplinski, Chrystèle Sanloup, Eric Gilabert, Denis Horlait
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Cryo-EM structure of a type IV secretion system Nature (IF 69.504) Pub Date : 2022-06-22 Kévin Macé, Abhinav K. Vadakkepat, Adam Redzej, Natalya Lukoyanova, Clasien Oomen, Nathalie Braun, Marta Ukleja, Fang Lu, Tiago R. D. Costa, Elena V. Orlova, David Baker, Qian Cong, Gabriel Waksman
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Induction of mouse totipotent stem cells by a defined chemical cocktail Nature (IF 69.504) Pub Date : 2022-06-21 Yanyan Hu, Yuanyuan Yang, Pengcheng Tan, Yuxia Zhang, Mengxia Han, Jiawei Yu, Xin Zhang, Zeran Jia, Dan Wang, Yinqing Li, Tianhua Ma, Kang Liu, Sheng Ding
In mice, only the zygotes and blastomeres from 2-cell embryos are authentic totipotent stem cells (TotiSCs), capable of producing all the differentiated cells in both embryonic and extraembryonic tissues and forming an entire organism1. However, it remains challenging whether and how TotiSCs, representing the very beginning of a life, can be established in vitro in the absence of germline cells. Here
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BA.2.12.1, BA.4 and BA.5 escape antibodies elicited by Omicron infection Nature (IF 69.504) Pub Date : 2022-06-17 Yunlong Cao, Ayijiang Yisimayi, Fanchong Jian, Weiliang Song, Tianhe Xiao, Lei Wang, Shuo Du, Jing Wang, Qianqian Li, Xiaosu Chen, Yuanling Yu, Peng Wang, Zhiying Zhang, Pulan Liu, Ran An, Xiaohua Hao, Yao Wang, Jing Wang, Rui Feng, Haiyan Sun, Lijuan Zhao, Wen Zhang, Dong Zhao, Jiang Zheng, Lingling Yu, Can Li, Na Zhang, Rui Wang, Xiao Niu, Sijie Yang, Xuetao Song, Yangyang Chai, Ye Hu, Yansong Shi
SARS-CoV-2 Omicron sublineages BA.2.12.1, BA.4 and BA.5 exhibit higher transmissibility over BA.21. The new variants’ receptor binding and immune evasion capability require immediate investigation. Here, coupled with Spike structural comparisons, we show that BA.2.12.1 and BA.4/BA.5 exhibit comparable ACE2-binding affinities to BA.2. Importantly, BA.2.12.1 and BA.4/BA.5 display stronger neutralization
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Site-selective, stereocontrolled glycosylation of minimally protected sugars Nature (IF 69.504) Pub Date : 2022-06-16 Qiuhan Li, Samuel M. Levi, Corin Wagen, Alison E. Wendlandt, Eric N. Jacobsen
The identification of general and efficient methods for the construction of oligosaccharides stands as one of the great challenges for the field of synthetic chemistry1,2. Selective glycosylation of unprotected sugars and other polyhydroxylated nucleophiles is a particularly significant goal, requiring not only control over the stereochemistry of the forming bond but also differentiation between similarly
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Spatial profiling of early primate gastrulation in utero Nature (IF 69.504) Pub Date : 2022-06-16 Sophie Bergmann, Christopher A. Penfold, Erin Slatery, Dylan Siriwardena, Charis Drummer, Stephen Clark, Stanley E. Strawbridge, Keiko Kishimoto, Alice Vickers, Mukul Tewary, Timo N. Kohler, Florian Hollfelder, Wolf Reik, Erika Sasaki, Rüdiger Behr, Thorsten E. Boroviak
Gastrulation controls the emergence of cellular diversity and axis patterning in the early embryo. In mammals, this transformation is orchestrated by dynamic signalling centres at the interface of embryonic and extraembryonic tissues1–3. Elucidating the molecular framework of axis formation in vivo is fundamental for our understanding of human development4–6 and to advance stem-cell-based regenerative
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Evidence for unconventional superconductivity in twisted trilayer graphene Nature (IF 69.504) Pub Date : 2022-06-15 Hyunjin Kim, Youngjoon Choi, Cyprian Lewandowski, Alex Thomson, Yiran Zhang, Robert Polski, Kenji Watanabe, Takashi Taniguchi, Jason Alicea, Stevan Nadj-Perge
Magic-angle twisted trilayer graphene (MATTG) has emerged as a moiré material that exhibits strong electronic correlations and unconventional superconductivity1,2. However, local spectroscopic studies of this system are still lacking. Here we perform high-resolution scanning tunnelling microscopy and spectroscopy of MATTG that reveal extensive regions of atomic reconstruction favouring mirror-symmetric
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The source of the Black Death in fourteenth-century central Eurasia Nature (IF 69.504) Pub Date : 2022-06-15 Maria A. Spyrou, Lyazzat Musralina, Guido A. Gnecchi Ruscone, Arthur Kocher, Pier-Giorgio Borbone, Valeri I. Khartanovich, Alexandra Buzhilova, Leyla Djansugurova, Kirsten I. Bos, Denise Kühnert, Wolfgang Haak, Philip Slavin, Johannes Krause
The origin of the medieval Black Death pandemic (ad 1346–1353) has been a topic of continuous investigation because of the pandemic’s extensive demographic impact and long-lasting consequences1,2. Until now, the most debated archaeological evidence potentially associated with the pandemic’s initiation derives from cemeteries located near Lake Issyk-Kul of modern-day Kyrgyzstan1,3,4,5,6,7,8,9. These
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Superconducting-qubit readout via low-backaction electro-optic transduction Nature (IF 69.504) Pub Date : 2022-06-15 R. D. Delaney, M. D. Urmey, S. Mittal, B. M. Brubaker, J. M. Kindem, P. S. Burns, C. A. Regal, K. W. Lehnert
Entangling microwave-frequency superconducting quantum processors through optical light at ambient temperature would enable means of secure communication and distributed quantum information processing1. However, transducing quantum signals between these disparate regimes of the electro-magnetic spectrum remains an outstanding goal2,3,4,5,6,7,8,9, and interfacing superconducting qubits, which are constrained
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Androgen receptor blockade promotes response to BRAF/MEK-targeted therapy Nature (IF 69.504) Pub Date : 2022-06-15 Christopher P. Vellano, Michael G. White, Miles C. Andrews, Manoj Chelvanambi, Russell G. Witt, Joseph R. Daniele, Mark Titus, Jennifer L. McQuade, Fabio Conforti, Elizabeth M. Burton, Matthew J. Lastrapes, Gabriel Ologun, Alexandria P. Cogdill, Golnaz Morad, Peter Prieto, Alexander J. Lazar, Yanshuo Chu, Guangchun Han, M. A. Wadud Khan, Beth Helmink, Michael A. Davies, Rodabe N. Amaria, Jeffrey J
Treatment with therapy targeting BRAF and MEK (BRAF/MEK) has revolutionized care in melanoma and other cancers; however, therapeutic resistance is common and innovative treatment strategies are needed1,2. Here we studied a group of patients with melanoma who were treated with neoadjuvant BRAF/MEK-targeted therapy (NCT02231775, n = 51) and observed significantly higher rates of major pathological response
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Mechanism of replication origin melting nucleated by CMG helicase assembly Nature (IF 69.504) Pub Date : 2022-06-15 Jacob S. Lewis, Marta H. Gross, Joana Sousa, Sarah S. Henrikus, Julia F. Greiwe, Andrea Nans, John F. X. Diffley, Alessandro Costa
The activation of eukaryotic origins of replication occurs in temporally separated steps to ensure that chromosomes are copied only once per cell cycle. First, the MCM helicase is loaded onto duplex DNA as an inactive double hexamer. Activation occurs after the recruitment of a set of firing factors that assemble two Cdc45–MCM–GINS (CMG) holo-helicases. CMG formation leads to the underwinding of DNA
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A pan-cancer compendium of chromosomal instability Nature (IF 69.504) Pub Date : 2022-06-15 Ruben M. Drews, Barbara Hernando, Maxime Tarabichi, Kerstin Haase, Tom Lesluyes, Philip S. Smith, Lena Morrill Gavarró, Dominique-Laurent Couturier, Lydia Liu, Michael Schneider, James D. Brenton, Peter Van Loo, Geoff Macintyre, Florian Markowetz
Chromosomal instability (CIN) results in the accumulation of large-scale losses, gains and rearrangements of DNA1. The broad genomic complexity caused by CIN is a hallmark of cancer2; however, there is no systematic framework to measure different types of CIN and their effect on clinical phenotypes pan-cancer. Here we evaluate the extent, diversity and origin of CIN across 7,880 tumours representing
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Deciphering the immunopeptidome in vivo reveals new tumour antigens Nature (IF 69.504) Pub Date : 2022-06-15 Alex M. Jaeger, Lauren E. Stopfer, Ryuhjin Ahn, Emma A. Sanders, Demi A. Sandel, William A. Freed-Pastor, William M. Rideout, Santiago Naranjo, Tim Fessenden, Kim B. Nguyen, Peter S. Winter, Ryan E. Kohn, Peter M. K. Westcott, Jason M. Schenkel, Sean-Luc Shanahan, Alex K. Shalek, Stefani Spranger, Forest M. White, Tyler Jacks
Immunosurveillance of cancer requires the presentation of peptide antigens on major histocompatibility complex class I (MHC-I) molecules1,2,3,4,5. Current approaches to profiling of MHC-I-associated peptides, collectively known as the immunopeptidome, are limited to in vitro investigation or bulk tumour lysates, which limits our understanding of cancer-specific patterns of antigen presentation in vivo6
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Peptidoglycan maturation controls outer membrane protein assembly Nature (IF 69.504) Pub Date : 2022-06-15 Gideon Mamou, Federico Corona, Ruth Cohen-Khait, Nicholas G. Housden, Vivian Yeung, Dawei Sun, Pooja Sridhar, Manuel Pazos, Timothy J. Knowles, Colin Kleanthous, Waldemar Vollmer
Linkages between the outer membrane of Gram-negative bacteria and the peptidoglycan layer are crucial for the maintenance of cellular integrity and enable survival in challenging environments1,2,3,4,5. The function of the outer membrane is dependent on outer membrane proteins (OMPs), which are inserted into the membrane by the β-barrel assembly machine6,7 (BAM). Growing Escherichia coli cells segregate
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A population of ultraviolet-dim protoclusters detected in absorption Nature (IF 69.504) Pub Date : 2022-06-15 Andrew B. Newman, Gwen C. Rudie, Guillermo A. Blanc, Mahdi Qezlou, Simeon Bird, Daniel D. Kelson, Victoria Pérez, Enrico Congiu, Brian C. Lemaux, Alan Dressler, John S. Mulchaey
Galaxy protoclusters, which will eventually grow into the massive clusters we see in the local Universe, are usually traced by locating overdensities of galaxies1. Large spectroscopic surveys of distant galaxies now exist, but their sensitivity depends mainly on a galaxy’s star-formation activity and dust content rather than its mass. Tracers of massive protoclusters that do not rely on their galaxy
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Signatures of copy number alterations in human cancer Nature (IF 69.504) Pub Date : 2022-06-15 Christopher D. Steele, Ammal Abbasi, S. M. Ashiqul Islam, Amy L. Bowes, Azhar Khandekar, Kerstin Haase, Shadi Hames-Fathi, Dolapo Ajayi, Annelien Verfaillie, Pawan Dhami, Alex McLatchie, Matt Lechner, Nicholas Light, Adam Shlien, David Malkin, Andrew Feber, Paula Proszek, Tom Lesluyes, Fredrik Mertens, Adrienne M. Flanagan, Maxime Tarabichi, Peter Van Loo, Ludmil B. Alexandrov, Nischalan Pillay
Gains and losses of DNA are prevalent in cancer and emerge as a consequence of inter-related processes of replication stress, mitotic errors, spindle multipolarity and breakage–fusion–bridge cycles, among others, which may lead to chromosomal instability and aneuploidy1,2. These copy number alterations contribute to cancer initiation, progression and therapeutic resistance3,4,5. Here we present a conceptual
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Caspase-7 activates ASM to repair gasdermin and perforin pores Nature (IF 69.504) Pub Date : 2022-06-15 Kengo Nozaki, Vivien I. Maltez, Manira Rayamajhi, Alan L. Tubbs, Joseph E. Mitchell, Carolyn A. Lacey, Carissa K. Harvest, Lupeng Li, William T. Nash, Heather N. Larson, Benjamin D. McGlaughon, Nathaniel J. Moorman, Michael G. Brown, Jason K. Whitmire, Edward A. Miao
Among the caspases that cause regulated cell death, a unique function for caspase-7 has remained elusive. Caspase-3 performs apoptosis, whereas caspase-7 is typically considered an inefficient back-up. Caspase-1 activates gasdermin D pores to lyse the cell; however, caspase-1 also activates caspase-7 for unknown reasons1. Caspases can also trigger cell-type-specific death responses; for example, caspase-1
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Lifelong multilineage contribution by embryonic-born blood progenitors Nature (IF 69.504) Pub Date : 2022-06-15 Sachin H. Patel, Constantina Christodoulou, Caleb Weinreb, Qi Yu, Edroaldo Lummertz da Rocha, Brian J. Pepe-Mooney, Sarah Bowling, Li Li, Fernando G. Osorio, George Q. Daley, Fernando D. Camargo
Haematopoietic stem cells (HSCs) arise in the embryo from the arterial endothelium through a process known as the endothelial-to-haematopoietic transition (EHT)1,2,3,4. This process generates hundreds of blood progenitors, of which a fraction go on to become definitive HSCs. It is generally thought that most adult blood is derived from those HSCs, but to what extent other progenitors contribute to
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Synthesis of a monolayer fullerene network Nature (IF 69.504) Pub Date : 2022-06-15 Lingxiang Hou, Xueping Cui, Bo Guan, Shaozhi Wang, Ruian Li, Yunqi Liu, Daoben Zhu, Jian Zheng
Two-dimensional (2D) carbon materials, such as graphene, have attracted particular attention owing to the exceptional carrier transport characteristics that arise from the unique π-electron system in their conjugated carbon network structure1,2,3,4. To complement zero-bandgap graphene, material scientists have devoted considerable effort to identifying 2D carbon materials5,6,7,8. However, it is a challenge
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An exercise-inducible metabolite that suppresses feeding and obesity Nature (IF 69.504) Pub Date : 2022-06-15 Veronica L. Li, Yang He, Kévin Contrepois, Hailan Liu, Joon T. Kim, Amanda L. Wiggenhorn, Julia T. Tanzo, Alan Sheng-Hwa Tung, Xuchao Lyu, Peter-James H. Zushin, Robert S. Jansen, Basil Michael, Kang Yong Loh, Andrew C. Yang, Christian S. Carl, Christian T. Voldstedlund, Wei Wei, Stephanie M. Terrell, Benjamin C. Moeller, Rick M. Arthur, Gareth A. Wallis, Koen van de Wetering, Andreas Stahl, Bente
Exercise confers protection against obesity, type 2 diabetes and other cardiometabolic diseases1,2,3,4,5. However, the molecular and cellular mechanisms that mediate the metabolic benefits of physical activity remain unclear6. Here we show that exercise stimulates the production of N-lactoyl-phenylalanine (Lac-Phe), a blood-borne signalling metabolite that suppresses feeding and obesity. The biosynthesis
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cGAS–STING drives the IL-6-dependent survival of chromosomally instable cancers Nature (IF 69.504) Pub Date : 2022-06-15 Christy Hong, Michael Schubert, Andréa E. Tijhuis, Marta Requesens, Maurits Roorda, Anouk van den Brink, Lorena Andrade Ruiz, Petra L. Bakker, Tineke van der Sluis, Wietske Pieters, Mengting Chen, René Wardenaar, Bert van der Vegt, Diana C. J. Spierings, Marco de Bruyn, Marcel A. T. M. van Vugt, Floris Foijer
Chromosomal instability (CIN) drives cancer cell evolution, metastasis and therapy resistance, and is associated with poor prognosis1. CIN leads to micronuclei that release DNA into the cytoplasm after rupture, which triggers activation of inflammatory signalling mediated by cGAS and STING2,3. These two proteins are considered to be tumour suppressors as they promote apoptosis and immunosurveillance
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Measurement of the bound-electron g-factor difference in coupled ions Nature (IF 69.504) Pub Date : 2022-06-15 Tim Sailer, Vincent Debierre, Zoltán Harman, Fabian Heiße, Charlotte König, Jonathan Morgner, Bingsheng Tu, Andrey V. Volotka, Christoph H. Keitel, Klaus Blaum, Sven Sturm
Quantum electrodynamics (QED) is one of the most fundamental theories of physics and has been shown to be in excellent agreement with experimental results1,2,3,4,5. In particular, measurements of the electron’s magnetic moment (or g factor) of highly charged ions in Penning traps provide a stringent probe for QED, which allows testing of the standard model in the strongest electromagnetic fields6.
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Global Tonga tsunami explained by a fast-moving atmospheric source Nature (IF 69.504) Pub Date : 2022-06-13 R. Omira, R. S. Ramalho, J. Kim, P. J. González, U. Kadri, J. M. Miranda, F. Carrilho, M. A. Baptista
Volcanoes can produce tsunamis through earthquakes, caldera and flank collapses, pyroclastic flows, or underwater explosions1,2,3,4. These mechanisms rarely displace enough water to trigger transoceanic tsunamis. Violent volcanic explosions, however, can cause global tsunamis1,5 by triggering acoustic-gravity waves6,7,8 that excite the atmosphere-ocean interface. The colossal eruption of the Hunga
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Axial Higgs mode detected by quantum pathway interference in RTe3 Nature (IF 69.504) Pub Date : 2022-06-08 Yiping Wang, Ioannis Petrides, Grant McNamara, Md Mofazzel Hosen, Shiming Lei, Yueh-Chun Wu, James L. Hart, Hongyan Lv, Jun Yan, Di Xiao, Judy J. Cha, Prineha Narang, Leslie M. Schoop, Kenneth S. Burch
The observation of the Higgs boson solidified the standard model of particle physics. However, explanations of anomalies (for example, dark matter) rely on further symmetry breaking, calling for an undiscovered axial Higgs mode1. The Higgs mode was also seen in magnetic, superconducting and charge density wave (CDW) systems2,3. Uncovering the vector properties of a low-energy mode is challenging, and