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Publisher Correction: VEGF-C-driven lymphatic drainage enables immunosurveillance of brain tumours Nature (IF 42.778) Pub Date : 2021-01-26 Eric Song; Tianyang Mao; Huiping Dong; Ligia Simoes Braga Boisserand; Salli Antila; Marcus Bosenberg; Kari Alitalo; Jean-Leon Thomas; Akiko Iwasaki
A Correction to this paper has been published: https://doi.org/10.1038/s41586-021-03204-z.
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Famed Chinese immunologist cleared of plagiarism and fraud Nature (IF 42.778) Pub Date : 2021-01-26 David Cyranoski
But Cao Xuetao will be barred from applying for grants for a year after investigators found ‘misused images’ in his group’s papers.
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Why you should consider becoming a doctoral representative Nature (IF 42.778) Pub Date : 2021-01-26 Michaela Löffler
Join a group that represents PhD researchers to improve the working environment of your colleagues and to make friends.
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Seven technologies to watch in 2021 Nature (IF 42.778) Pub Date : 2021-01-26 Esther Landhuis
COVID considerations unsurprisingly dominate the tech developments that could have a big impact in the coming year.
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Cancer research needs a better map Nature (IF 42.778) Pub Date : 2021-01-26 Jesse S. Boehm; Mathew J. Garnett; David J. Adams; Hayley E. Francies; Todd R. Golub; William C. Hahn; Francesco Iorio; James M. McFarland; Leopold Parts; Francisca Vazquez
It is time to move beyond tumour sequencing data to identify vulnerabilities in cancers.
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‘The problem is greater than it’s ever been’: US universities urged to invest in mental-health resources Nature (IF 42.778) Pub Date : 2021-01-25 Chris Woolston
National Academies report finds that graduate students are at risk in mental-health ‘crisis’ on campuses nationwide.
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Daily briefing: Retracted COVID papers are still being cited Nature (IF 42.778) Pub Date : 2021-01-25 Flora Graham
Most citations of discredited Surgisphere research fail to mention retractions. Plus, why the world’s pandemic warning system failed when COVID hit and how uncertainty can sharpen our thinking.
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Design and analysis of a planar UWB bandpass filter with stopband characteristics using MMR technique Int. J. Microw. Wirel. Technol. (IF 0.939) Pub Date : 2021-01-26 Gaurav Saxena; Priyanka Jain; Y. K. Awasthi
In this paper, a ultra-wideband (UWB) bandpass filter with stopband characteristics is presented using a multi-mode resonator (MMR) technique. An MMR is formed by loading three dumbbell-shaped (Mickey and circular) shunt stubs placed in the center and two symmetrical locations from ports, respectively. Three circular and arrowhead defected ground structures on the ground plane are introduced to achieve
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Optimum design of linear and circular antenna arrays using equilibrium optimization algorithm Int. J. Microw. Wirel. Technol. (IF 0.939) Pub Date : 2021-01-26 Ali Durmus; Rifat Kurban
In this paper, equilibrium optimization algorithm (EOA), which is a novel optimization algorithm, is applied to synthesize symmetrical linear antenna array and non-uniform circular antenna array (CAA). The main purpose of antenna array synthesis is to achieve a radiation pattern with low maximum side lobe level (MSL) and narrow half-power beam width (HPBW) in far-field. The low MSL here is an important
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A Pythagorean tree fractal shape stub-loaded resonator as a UWB bandpass filter with wide stopband Int. J. Microw. Wirel. Technol. (IF 0.939) Pub Date : 2021-01-26 Puja Kumari; Pankaj Sarkar; Rowdra Ghatak
A compact ultrawideband (UWB) bandpass filter (BPF) is designed by harnessing the efficacy of a Pythagorean tree fractal shape stub-loaded resonator. The design inherently provides the passband transmission poles, which make it convenient to be used in wide passband filtering circuits. The number and the position of the resonating modes can be controlled by increasing the iterations of the Pythagorean
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Front Cover IEEE Internet Things J. (IF 9.936) Pub Date : 2021-01-22
Presents the front cover for this issue of the publication.
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IEEE Internet of Things Journal IEEE Internet Things J. (IF 9.936) Pub Date : 2021-01-22
Presents a listing of the editorial board, board of governors, current staff, committee members, and/or society editors for this issue of the publication.
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Table of contents IEEE Internet Things J. (IF 9.936) Pub Date : 2021-01-22
Presents the table of contents for this issue of the publication.
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IEEE Internet of Things Journal IEEE Internet Things J. (IF 9.936) Pub Date : 2021-01-22
Presents a listing of the editorial board, board of governors, current staff, committee members, and/or society editors for this issue of the publication.
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Information for Authors IEEE Internet Things J. (IF 9.936) Pub Date : 2021-01-22
These instructions give guidelines for preparing papers for this publication. Presents information for authors publishing in this journal.
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Correction for Pu et al., Maternal glyphosate exposure causes autism-like behaviors in offspring through increased expression of soluble epoxide hydrolase [Corrections] Proc. Natl. Acad. Sci. U.S.A. (IF 9.412) Pub Date : 2021-02-02 National Academy of Sciences
NEUROSCIENCE Correction for “Maternal glyphosate exposure causes autism-like behaviors in offspring through increased expression of soluble epoxide hydrolase,” by Yaoyu Pu, Jun Yang, Lijia Chang, Youge Qu, Siming …
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Correction for Bryant et al., Detecting affiliation in colaughter across 24 societies [Corrections] Proc. Natl. Acad. Sci. U.S.A. (IF 9.412) Pub Date : 2021-02-02 National Academy of Sciences
PSYCHOLOGICAL AND COGNITIVE SCIENCES Correction for “Detecting affiliation in colaughter across 24 societies,” by Gregory A. Bryant, Daniel M. T. Fessler, Riccardo Fusaroli, Edward Clint, Lene Aarøe, Coren L. Apicella, …
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Reply to Letten and Yamamichi: A rescue at the cost of falsifiability [Biological Sciences] Proc. Natl. Acad. Sci. U.S.A. (IF 9.412) Pub Date : 2021-02-02 Thomas Kiørboe, Mridul K. Thomas
Letten and Yamamichi (1) make valuable comments about our recent paper (2). They point out that the gleaner−exploiter trade-off commonly refers to population growth rates and not prey consumption (the focus of our study). We agree and should have made our reasoning clearer. We assume that food consumption and population growth rates are positively associated; therefore, a positive association between
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Nascent fusion pore opening monitored at single-SNAREpin resolution [Biophysics and Computational Biology] Proc. Natl. Acad. Sci. U.S.A. (IF 9.412) Pub Date : 2021-02-02 Paul Heo, Jeff Coleman, Jean-Baptiste Fleury, James E. Rothman, Frederic Pincet
Vesicle fusion with a target membrane is a key event in cellular trafficking and ensures cargo transport within the cell and between cells. The formation of a protein complex, called SNAREpin, provides the energy necessary for the fusion process. In a three-dimensional microfluidic chip, we monitored the fusion of small vesicles with a suspended asymmetric lipid bilayer. Adding ion channels into the
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Herbert Tabor, 1918-2020: Polyamines, NIH, and the JBC [Retrospectives] Proc. Natl. Acad. Sci. U.S.A. (IF 9.412) Pub Date : 2021-02-02 Reed B. Wickner
On August 20, 2020, at the age of 101, Herbert Tabor died peacefully at his home on the National Institutes of Health campus in Bethesda, Maryland. Herb was best known for his elucidation of the biochemical pathways for polyamines, including characterization of the biosynthetic enzymes, their genes and regulation, and the functions of the polyamines, chiefly using Escherichia coli and Saccharomyces
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Mechanistic basis of propofol-induced disruption of kinesin processivity [Biophysics and Computational Biology] Proc. Natl. Acad. Sci. U.S.A. (IF 9.412) Pub Date : 2021-02-02 Mandira Dutta, Susan P. Gilbert, José N. Onuchic, Biman Jana
Propofol is a widely used general anesthetic to induce and maintain anesthesia, and its effects are thought to occur through impact on the ligand-gated channels including the GABAA receptor. Propofol also interacts with a large number of proteins including molecular motors and inhibits kinesin processivity, resulting in significant decrease in the run length for conventional kinesin-1 and kinesin-2
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DNA methylation-linked chromatin accessibility affects genomic architecture in Arabidopsis [Plant Biology] Proc. Natl. Acad. Sci. U.S.A. (IF 9.412) Pub Date : 2021-02-02 Zhenhui Zhong, Suhua Feng, Sascha H. Duttke, Magdalena E. Potok, Yiwei Zhang, Javier Gallego-Bartolomé, Wanlu Liu, Steven E. Jacobsen
DNA methylation is a major epigenetic modification found across species and has a profound impact on many biological processes. However, its influence on chromatin accessibility and higher-order genome organization remains unclear, particularly in plants. Here, we present genome-wide chromatin accessibility profiles of 18 Arabidopsis mutants that are deficient in CG, CHG, or CHH DNA methylation. We
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Gleaning, fast and slow: In defense of a canonical ecological trade-off [Biological Sciences] Proc. Natl. Acad. Sci. U.S.A. (IF 9.412) Pub Date : 2021-02-02 Andrew D. Letten, Masato Yamamichi
In an elegant analysis of resource utilization data from >500 eukaryote species, Kiørboe and Thomas (1) describe a positive relationship between the rate at which organisms acquire and ingest food. From this, they infer that “perhaps the most commonly assumed trade-off in ecology—between relative performance at low and high resource (food) levels—does not exist.” Notwithstanding the independent value
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Universal law for the vibrational density of states of liquids [Applied Physical Sciences] Proc. Natl. Acad. Sci. U.S.A. (IF 9.412) Pub Date : 2021-02-02 Alessio Zaccone, Matteo Baggioli
An analytical derivation of the vibrational density of states (DOS) of liquids, and, in particular, of its characteristic linear in frequency low-energy regime, has always been elusive because of the presence of an infinite set of purely imaginary modes—the instantaneous normal modes (INMs). By combining an analytic continuation of the Plemelj identity to the complex plane with the overdamped dynamics
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Lysergic acid diethylamide (LSD) promotes social behavior through mTORC1 in the excitatory neurotransmission [Neuroscience] Proc. Natl. Acad. Sci. U.S.A. (IF 9.412) Pub Date : 2021-02-02 Danilo De Gregorio, Jelena Popic, Justine P. Enns, Antonio Inserra, Agnieszka Skalecka, Athanasios Markopoulos, Luca Posa, Martha Lopez-Canul, He Qianzi, Christopher K. Lafferty, Jonathan P. Britt, Stefano Comai, Argel Aguilar-Valles, Nahum Sonenberg, Gabriella Gobbi
Clinical studies have reported that the psychedelic lysergic acid diethylamide (LSD) enhances empathy and social behavior (SB) in humans, but its mechanism of action remains elusive. Using a multidisciplinary approach including in vivo electrophysiology, optogenetics, behavioral paradigms, and molecular biology, the effects of LSD on SB and glutamatergic neurotransmission in the medial prefrontal cortex
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Performance of molecular crystals in conversion of light to mechanical work [Chemistry] Proc. Natl. Acad. Sci. U.S.A. (IF 9.412) Pub Date : 2021-02-02 Jad Mahmoud Halabi, Ejaz Ahmed, Samuel Sofela, Panče Naumov
Dynamic molecular crystals have recently received ample attention as an emerging class of energy-transducing materials, yet have fallen short of developing into fully realized actuators. Through the trans–cis surface isomerization of three crystalline azobenzene materials, here, we set out to extensively characterize the light-to-work energy conversion of photoinduced bending in molecular crystals
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Tumor-suppressor function of Beclin 1 in breast cancer cells requires E-cadherin [Cell Biology] Proc. Natl. Acad. Sci. U.S.A. (IF 9.412) Pub Date : 2021-02-02 Tobias Wijshake, Zhongju Zou, Beibei Chen, Lin Zhong, Guanghua Xiao, Yang Xie, John G. Doench, Lynda Bennett, Beth Levine
Beclin 1, an autophagy and haploinsufficient tumor-suppressor protein, is frequently monoallelically deleted in breast and ovarian cancers. However, the precise mechanisms by which Beclin 1 inhibits tumor growth remain largely unknown. To address this question, we performed a genome-wide CRISPR/Cas9 screen in MCF7 breast cancer cells to identify genes whose loss of function reverse Beclin 1-dependent
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Targeting OCT3 attenuates doxorubicin-induced cardiac injury [Pharmacology] Proc. Natl. Acad. Sci. U.S.A. (IF 9.412) Pub Date : 2021-02-02 Kevin M. Huang, Megan Zavorka Thomas, Tarek Magdy, Eric D. Eisenmann, Muhammad Erfan Uddin, Duncan F. DiGiacomo, Alexander Pan, Markus Keiser, Marcus Otter, Sherry H. Xia, Yang Li, Yan Jin, Qiang Fu, Alice A. Gibson, Ingrid M. Bonilla, Cynthia A. Carnes, Kara N. Corps, Vincenzo Coppola, Sakima A. Smith, Daniel Addison, Anne T. Nies, Ralf Bundschuh, Taosheng Chen, Maryam B. Lustberg, Joanne Wang, Stefan
Doxorubicin is a commonly used anticancer agent that can cause debilitating and irreversible cardiac injury. The initiating mechanisms contributing to this side effect remain unknown, and current preventative strategies offer only modest protection. Using stem-cell–derived cardiomyocytes from patients receiving doxorubicin, we probed the transcriptomic landscape of solute carriers and identified organic
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Timing matters when correcting fake news [Political Sciences] Proc. Natl. Acad. Sci. U.S.A. (IF 9.412) Pub Date : 2021-02-02 Nadia M. Brashier, Gordon Pennycook, Adam J. Berinsky, David G. Rand
Countering misinformation can reduce belief in the moment, but corrective messages quickly fade from memory. We tested whether the longer-term impact of fact-checks depends on when people receive them. In two experiments (total N = 2,683), participants read true and false headlines taken from social media. In the treatment conditions, “true” and “false” tags appeared before, during, or after participants
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Genome-wide detection of cytosine methylation by single molecule real-time sequencing [Medical Sciences] Proc. Natl. Acad. Sci. U.S.A. (IF 9.412) Pub Date : 2021-02-02 O. Y. Olivia Tse, Peiyong Jiang, Suk Hang Cheng, Wenlei Peng, Huimin Shang, John Wong, Stephen L. Chan, Liona C. Y. Poon, Tak Y. Leung, K. C. Allen Chan, Rossa W. K. Chiu, Y. M. Dennis Lo
5-Methylcytosine (5mC) is an important type of epigenetic modification. Bisulfite sequencing (BS-seq) has limitations, such as severe DNA degradation. Using single molecule real-time sequencing, we developed a methodology to directly examine 5mC. This approach holistically examined kinetic signals of a DNA polymerase (including interpulse duration and pulse width) and sequence context for every nucleotide
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Drosophila Sex Peptide controls the assembly of lipid microcarriers in seminal fluid [Cell Biology] Proc. Natl. Acad. Sci. U.S.A. (IF 9.412) Pub Date : 2021-02-02 S. Mark Wainwright, Ben R. Hopkins, Cláudia C. Mendes, Aashika Sekar, Benjamin Kroeger, Josephine E. E. U. Hellberg, Shih-Jung Fan, Abigail Pavey, Pauline P. Marie, Aaron Leiblich, Irem Sepil, Philip D. Charles, Marie L. Thézénas, Roman Fischer, Benedikt M. Kessler, Carina Gandy, Laura Corrigan, Rachel Patel, Stuart Wigby, John F. Morris, Deborah C. I. Goberdhan, Clive Wilson
Seminal fluid plays an essential role in promoting male reproductive success and modulating female physiology and behavior. In the fruit fly, Drosophila melanogaster, Sex Peptide (SP) is the best-characterized protein mediator of these effects. It is secreted from the paired male accessory glands (AGs), which, like the mammalian prostate and seminal vesicles, generate most of the seminal fluid contents
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Structural insights into a dimeric Psb27-photosystem II complex from a cyanobacterium Thermosynechococcus vulcanus [Biophysics and Computational Biology] Proc. Natl. Acad. Sci. U.S.A. (IF 9.412) Pub Date : 2021-02-02 Guoqiang Huang, Yanan Xiao, Xiong Pi, Liang Zhao, Qingjun Zhu, Wenda Wang, Tingyun Kuang, Guangye Han, Sen-Fang Sui, Jian-Ren Shen
Photosystem II (PSII) is a multisubunit pigment-protein complex and catalyzes light-driven water oxidation, leading to the conversion of light energy into chemical energy and the release of molecular oxygen. Psb27 is a small thylakoid lumen-localized protein known to serve as an assembly factor for the biogenesis and repair of the PSII complex. The exact location and binding fashion of Psb27 in the
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The mortality impacts of current and planned coal-fired power plants in India [Sustainability Science] Proc. Natl. Acad. Sci. U.S.A. (IF 9.412) Pub Date : 2021-02-02 Maureen Cropper, Ryna Cui, Sarath Guttikunda, Nate Hultman, Puja Jawahar, Yongjoon Park, Xinlu Yao, Xiao-Peng Song
We examine the health implications of electricity generation from the 2018 stock of coal-fired power plants in India, as well as the health impacts of the expansion in coal-fired generation capacity expected to occur by 2030. We estimate emissions of SO2, NOX, and particulate matter 2.5 μm (PM2.5) for each plant and use a chemical transport model to estimate the impact of power plant emissions on ambient
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A protease-mediated mechanism regulates the cytochrome c6/plastocyanin switch in Synechocystis sp. PCC 6803 [Plant Biology] Proc. Natl. Acad. Sci. U.S.A. (IF 9.412) Pub Date : 2021-02-02 Raquel García-Cañas, Joaquín Giner-Lamia, Francisco J. Florencio, Luis López-Maury
After the Great Oxidation Event (GOE), iron availability was greatly decreased, and photosynthetic organisms evolved several alternative proteins and mechanisms. One of these proteins, plastocyanin, is a type I blue-copper protein that can replace cytochrome c6 as a soluble electron carrier between cytochrome b6f and photosystem I. In most cyanobacteria, expression of these two alternative proteins
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Efficient detection and post-surgical monitoring of colon cancer with a multi-marker DNA methylation liquid biopsy [Medical Sciences] Proc. Natl. Acad. Sci. U.S.A. (IF 9.412) Pub Date : 2021-02-02 Shengnan Jin, Dewen Zhu, Fanggui Shao, Shiliang Chen, Ying Guo, Kuan Li, Yourong Wang, Rongxiu Ding, Lingjia Gao, Wen Ma, Tong Lu, Dandan Li, Zhengzheng Zhang, Suili Cai, Xue Liang, Huayu Song, Ling Ji, Jinlei Li, Zhihai Zheng, Feizhao Jiang, Xiaoli Wu, Ju Luan, Huxiang Zhang, Zhengquan Yang, Charles R. Cantor, Chang Xu, Chunming Ding
Multiplex assays, involving the simultaneous use of multiple circulating tumor DNA (ctDNA) markers, can improve the performance of liquid biopsies so that they are highly predictive of cancer recurrence. We have developed a single-tube methylation-specific quantitative PCR assay (mqMSP) that uses 10 different methylation markers and is capable of quantitative analysis of plasma samples with as little
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The diversity bonus in pooling local knowledge about complex problems [Sustainability Science] Proc. Natl. Acad. Sci. U.S.A. (IF 9.412) Pub Date : 2021-02-02 Payam Aminpour, Steven A. Gray, Alison Singer, Steven B. Scyphers, Antonie J. Jetter, Rebecca Jordan, Robert Murphy, Jonathan H. Grabowski
Recently, theoreticians have hypothesized that diverse groups, as opposed to groups that are homogeneous, may have relative merits [S. E. Page, The Diversity Bonus (2019)]—all of which lead to more success in solving complex problems. As such, understanding complex, intertwined environmental and social issues may benefit from the integration of diverse types of local expertise. However, efforts to
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Sensing the presence of gods and spirits across cultures and faiths Proc. Natl. Acad. Sci. U.S.A. (IF 9.412) Pub Date : 2021-02-02 Tanya Marie Luhrmann, Kara Weisman, Felicity Aulino, Joshua D. Brahinsky, John C. Dulin, Vivian A. Dzokoto, Cristine H. Legare, Michael Lifshitz, Emily Ng, Nicole Ross-Zehnder, Rachel E. Smith
Hearing the voice of God, feeling the presence of the dead, being possessed by a demonic spirit—such events are among the most remarkable human sensory experiences. They change lives and in turn shape history. Why do some people report experiencing such events while others do not? We argue that experiences of spiritual presence are facilitated by cultural models that represent the mind as “porous,”
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Effects of management outweigh effects of plant diversity on restored animal communities in tallgrass prairies [Sustainability Science] Proc. Natl. Acad. Sci. U.S.A. (IF 9.412) Pub Date : 2021-02-02 Peter W. Guiden, Nicholas A. Barber, Ryan Blackburn, Anna Farrell, Jessica Fliginger, Sheryl C. Hosler, Richard B. King, Melissa Nelson, Erin G. Rowland, Kirstie Savage, John P. Vanek, Holly P. Jones
A primary goal of ecological restoration is to increase biodiversity in degraded ecosystems. However, the success of restoration ecology is often assessed by measuring the response of a single functional group or trophic level to restoration, without considering how restoration affects multitrophic interactions that shape biodiversity. An ecosystem-wide approach to restoration is therefore necessary
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SIRT7-dependent deacetylation of NPM promotes p53 stabilization following UV-induced genotoxic stress [Cell Biology] Proc. Natl. Acad. Sci. U.S.A. (IF 9.412) Pub Date : 2021-02-02 Alessandro Ianni, Poonam Kumari, Shahriar Tarighi, Nicolas G. Simonet, Daniela Popescu, Stefan Guenther, Soraya Hölper, Andreas Schmidt, Christian Smolka, Shijing Yue, Marcus Krüger, Claudia Fiorillo, Alejandro Vaquero, Eva Bober, Thomas Braun
Adaptation to different forms of environmental stress is crucial for maintaining essential cellular functions and survival. The nucleolus plays a decisive role as a signaling hub for coordinating cellular responses to various extrinsic and intrinsic cues. p53 levels are normally kept low in unstressed cells, mainly due to E3 ubiquitin ligase MDM2-mediated degradation. Under stress, nucleophosmin (NPM)
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Reassessment of the phylogenetic relationships of the late Miocene apes Hispanopithecus and Rudapithecus based on vestibular morphology [Anthropology] Proc. Natl. Acad. Sci. U.S.A. (IF 9.412) Pub Date : 2021-02-02 Alessandro Urciuoli, Clément Zanolli, Sergio Almécija, Amélie Beaudet, Jean Dumoncel, Naoki Morimoto, Masato Nakatsukasa, Salvador Moyà-Solà, David R. Begun, David M. Alba
Late Miocene great apes are key to reconstructing the ancestral morphotype from which earliest hominins evolved. Despite consensus that the late Miocene dryopith great apes Hispanopithecus laietanus (Spain) and Rudapithecus hungaricus (Hungary) are closely related (Hominidae), ongoing debate on their phylogenetic relationships with extant apes (stem hominids, hominines, or pongines) complicates our
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Genome-wide CRISPR screens reveal a specific ligand for the glycan-binding immune checkpoint receptor Siglec-7 [Biochemistry] Proc. Natl. Acad. Sci. U.S.A. (IF 9.412) Pub Date : 2021-02-02 Simon Wisnovsky, Leonhard Möckl, Stacy A. Malaker, Kayvon Pedram, Gaelen T. Hess, Nicholas M. Riley, Melissa A. Gray, Benjamin A. H. Smith, Michael C. Bassik, W. E. Moerner, Carolyn R. Bertozzi
Glyco-immune checkpoint receptors, molecules that inhibit immune cell activity following binding to glycosylated cell-surface antigens, are emerging as attractive targets for cancer immunotherapy. Defining biologically relevant ligands that bind and activate such receptors, however, has historically been a significant challenge. Here, we present a CRISPRi genomic screening strategy that allowed unbiased
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Replication-independent instability of Friedreich’s ataxia GAA repeats during chronological aging [Genetics] Proc. Natl. Acad. Sci. U.S.A. (IF 9.412) Pub Date : 2021-02-02 Alexander J. Neil, Julia A. Hisey, Ishtiaque Quasem, Ryan J. McGinty, Marcin Hitczenko, Alexandra N. Khristich, Sergei M. Mirkin
Nearly 50 hereditary diseases result from the inheritance of abnormally long repetitive DNA microsatellites. While it was originally believed that the size of inherited repeats is the key factor in disease development, it has become clear that somatic instability of these repeats throughout an individual’s lifetime strongly contributes to disease onset and progression. Importantly, somatic instability
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Anomalous influenza seasonality in the United States and the emergence of novel influenza B viruses [Population Biology] Proc. Natl. Acad. Sci. U.S.A. (IF 9.412) Pub Date : 2021-02-02 Rebecca K. Borchering, Christian E. Gunning, Deven V. Gokhale, K. Bodie Weedop, Arash Saeidpour, Tobias S. Brett, Pejman Rohani
The 2019/2020 influenza season in the United States began earlier than any season since the 2009 H1N1 pandemic, with an increase in influenza-like illnesses observed as early as August. Also noteworthy was the numerical domination of influenza B cases early in this influenza season, in contrast to their typically later peak in the past. Here, we dissect the 2019/2020 influenza season not only with
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Nanopore-mediated protein delivery enabling three-color single-molecule tracking in living cells [Chemistry] Proc. Natl. Acad. Sci. U.S.A. (IF 9.412) Pub Date : 2021-02-02 Zhongwen Chen, Yuhong Cao, Chun-Wei Lin, Steven Alvarez, Dongmyung Oh, Peidong Yang, Jay T. Groves
Multicolor single-molecule tracking (SMT) provides a powerful tool to mechanistically probe molecular interactions in living cells. However, because of the limitations in the optical and chemical properties of currently available fluorophores and the multiprotein labeling strategies, intracellular multicolor SMT remains challenging for general research studies. Here, we introduce a practical method
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Laboratory earthquake forecasting: A machine learning competition [Earth, Atmospheric, and Planetary Sciences] Proc. Natl. Acad. Sci. U.S.A. (IF 9.412) Pub Date : 2021-02-02 Paul A. Johnson, Bertrand Rouet-Leduc, Laura J. Pyrak-Nolte, Gregory C. Beroza, Chris J. Marone, Claudia Hulbert, Addison Howard, Philipp Singer, Dmitry Gordeev, Dimosthenis Karaflos, Corey J. Levinson, Pascal Pfeiffer, Kin Ming Puk, Walter Reade
Earthquake prediction, the long-sought holy grail of earthquake science, continues to confound Earth scientists. Could we make advances by crowdsourcing, drawing from the vast knowledge and creativity of the machine learning (ML) community? We used Google’s ML competition platform, Kaggle, to engage the worldwide ML community with a competition to develop and improve data analysis approaches on a forecasting
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Unexpected nascent atmospheric emissions of three ozone-depleting hydrochlorofluorocarbons [Earth, Atmospheric, and Planetary Sciences] Proc. Natl. Acad. Sci. U.S.A. (IF 9.412) Pub Date : 2021-02-02 Martin K. Vollmer, Jens Mühle, Stephan Henne, Dickon Young, Matthew Rigby, Blagoj Mitrevski, Sunyoung Park, Chris R. Lunder, Tae Siek Rhee, Christina M. Harth, Matthias Hill, Ray L. Langenfelds, Myriam Guillevic, Paul M. Schlauri, Ove Hermansen, Jgor Arduini, Ray H. J. Wang, Peter K. Salameh, Michela Maione, Paul B. Krummel, Stefan Reimann, Simon O’Doherty, Peter G. Simmonds, Paul J. Fraser, Ronald
Global and regional atmospheric measurements and modeling can play key roles in discovering and quantifying unexpected nascent emissions of environmentally important substances. We focus here on three hydrochlorofluorocarbons (HCFCs) that are restricted by the Montreal Protocol because of their roles in stratospheric ozone depletion. Based on measurements of archived air samples and on in situ measurements
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Abscisic acid regulates secondary cell-wall formation and lignin deposition in Arabidopsis thaliana through phosphorylation of NST1 [Plant Biology] Proc. Natl. Acad. Sci. U.S.A. (IF 9.412) Pub Date : 2021-02-02 Chang Liu, Hasi Yu, Xiaolan Rao, Laigeng Li, Richard A. Dixon
Plant secondary cell-wall (SCW) deposition and lignification are affected by both seasonal factors and abiotic stress, and these responses may involve the hormone abscisic acid (ABA). However, the mechanisms involved are not clear. Here we show that mutations that limit ABA synthesis or signaling reduce the extent of SCW thickness and lignification in Arabidopsis thaliana through the core ABA-signaling
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Virus-like insertions with sequence signatures similar to those of endogenous nonretroviral RNA viruses in the human genome [Genetics] Proc. Natl. Acad. Sci. U.S.A. (IF 9.412) Pub Date : 2021-02-02 Shohei Kojima, Kohei Yoshikawa, Jumpei Ito, So Nakagawa, Nicholas F. Parrish, Masayuki Horie, Shuichi Kawano, Keizo Tomonaga
Understanding the genetics and taxonomy of ancient viruses will give us great insights into not only the origin and evolution of viruses but also how viral infections played roles in our evolution. Endogenous viruses are remnants of ancient viral infections and are thought to retain the genetic characteristics of viruses from ancient times. In this study, we used machine learning of endogenous RNA
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Loss of hepatic miR-33 improves metabolic homeostasis and liver function without altering body weight or atherosclerosis [Physiology] Proc. Natl. Acad. Sci. U.S.A. (IF 9.412) Pub Date : 2021-02-02 Nathan L. Price, Xinbo Zhang, Pablo Fernández-Tussy, Abhishek K. Singh, Sean A. Burnap, Noemi Rotllan, Leigh Goedeke, Jonathan Sun, Alberto Canfrán-Duque, Binod Aryal, Manuel Mayr, Yajaira Suárez, Carlos Fernández-Hernando
miR-33 is an intronic microRNA within the gene encoding the SREBP2 transcription factor. Like its host gene, miR-33 has been shown to be an important regulator of lipid metabolism. Inhibition of miR-33 has been shown to promote cholesterol efflux in macrophages by targeting the cholesterol transporter ABCA1, thus reducing atherosclerotic plaque burden. Inhibition of miR-33 has also been shown to improve
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Time-evolving controllability of effective connectivity networks during seizure progression [Applied Mathematics] Proc. Natl. Acad. Sci. U.S.A. (IF 9.412) Pub Date : 2021-02-02 Brittany H. Scheid, Arian Ashourvan, Jennifer Stiso, Kathryn A. Davis, Fadi Mikhail, Fabio Pasqualetti, Brian Litt, Danielle S. Bassett
Over one third of the estimated 3 million people with epilepsy in the United States are medication resistant. Responsive neurostimulation from chronically implanted electrodes provides a promising treatment alternative to resective surgery. However, determining optimal personalized stimulation parameters, including when and where to intervene to guarantee a positive patient outcome, is a major open
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Bistability in oxidative stress response determines the migration behavior of phytoplankton in turbulence [Biophysics and Computational Biology] Proc. Natl. Acad. Sci. U.S.A. (IF 9.412) Pub Date : 2021-02-02 Francesco Carrara, Anupam Sengupta, Lars Behrendt, Assaf Vardi, Roman Stocker
Turbulence is an important determinant of phytoplankton physiology, often leading to cell stress and damage. Turbulence affects phytoplankton migration both by transporting cells and by triggering switches in migratory behavior, whereby vertically migrating cells can actively invert their direction of migration upon exposure to turbulent cues. However, a mechanistic link between single-cell physiology
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Energetics and fear of humans constrain the spatial ecology of pumas [Environmental Sciences] Proc. Natl. Acad. Sci. U.S.A. (IF 9.412) Pub Date : 2021-02-02 Barry A. Nickel, Justin P. Suraci, Anna C. Nisi, Christopher C. Wilmers
Energetic demands and fear of predators are considered primary factors shaping animal behavior, and both are likely drivers of movement decisions that ultimately determine the spatial ecology of wildlife. Yet energetic constraints on movement imposed by the physical landscape have only been considered separately from those imposed by risk avoidance, limiting our understanding of how short-term movement
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DUB esterase activity further decodes ubiquitin’s enigma [Biochemistry] Proc. Natl. Acad. Sci. U.S.A. (IF 9.412) Pub Date : 2021-02-09 Benedikt M. Kessler
Posttranslational modifications of proteins are often key to understanding their biological function, localization, and fate. In particular, the covalent attachment of ubiquitin, a small 76-amino acid polypeptide, to substrates has attracted recent attention and is being exploited to generate novel drugs capable of removing pathogenic targets in a selective fashion (proteolysis-targeting chimeras)
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Charles M. Radding: A love of science and art [Retrospectives] Proc. Natl. Acad. Sci. U.S.A. (IF 9.412) Pub Date : 2021-02-09 Stephen C. West, Stephen C. Kowalczykowski
Charles M. Radding, a pioneer of recombination biochemistry, passed away on October 20, 2020, at the age of 90. Charles was a world-renowned scientist who made major contributions to the fields of DNA recombination and repair, in particular through his mechanistic studies of the RecA protein. He was a man of humor and warmth, and an eloquent and inspiring lecturer who had a profound influence on others
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Estimating computational limits on theoretical descriptions of biological cells [Biophysics and Computational Biology] Proc. Natl. Acad. Sci. U.S.A. (IF 9.412) Pub Date : 2021-02-09 Roland R. Netz, William A. Eaton
There has been much success recently in theoretically simulating parts of complex biological systems on the molecular level, with the goal of first-principles modeling of whole cells. However, there is the question of whether such simulations can be performed because of the enormous complexity of cells. We establish approximate equations to estimate computation times required to simulate highly simplified
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Arsenic trioxide replacing or reducing chemotherapy in consolidation therapy for acute promyelocytic leukemia (APL2012 trial) [Medical Sciences] Proc. Natl. Acad. Sci. U.S.A. (IF 9.412) Pub Date : 2021-02-09 Li Chen, Hong-Ming Zhu, Yan Li, Qi-Fa Liu, Yu Hu, Jian-Feng Zhou, Jie Jin, Jian-Da Hu, Ting Liu, De-Pei Wu, Jie-Ping Chen, Yong-Rong Lai, Jian-Xiang Wang, Juan Li, Jian-Yong Li, Xin Du, Xin Wang, Ming-Zhen Yang, Jin-Song Yan, Gui-Fang Ouyang, Li Liu, Ming Hou, Xiao-Jun Huang, Xiao-Jing Yan, Dan Xu, Wei-Ming Li, Deng-Ju Li, Yin-Jun Lou, Zheng-Jun Wu, Ting Niu, Ying Wang, Xiao-Yang Li, Jian-Hua You,
As all-trans retinoic acid (ATRA) and arsenic trioxide (ATO) are widely accepted in treating acute promyelocytic leukemia (APL), deescalating toxicity becomes a research hotspot. Here, we evaluated whether chemotherapy could be replaced or reduced by ATO in APL patients at different risks. After achieving complete remission with ATRA-ATO–based induction therapy, patients were randomized (1:1) into
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Dog domestication and the dual dispersal of people and dogs into the Americas [Genetics] Proc. Natl. Acad. Sci. U.S.A. (IF 9.412) Pub Date : 2021-02-09 Angela R. Perri, Tatiana R. Feuerborn, Laurent A. F. Frantz, Greger Larson, Ripan S. Malhi, David J. Meltzer, Kelsey E. Witt
Advances in the isolation and sequencing of ancient DNA have begun to reveal the population histories of both people and dogs. Over the last 10,000 y, the genetic signatures of ancient dog remains have been linked with known human dispersals in regions such as the Arctic and the remote Pacific. It is suspected, however, that this relationship has a much deeper antiquity, and that the tandem movement
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Personal experiences bridge moral and political divides better than facts [Psychological and Cognitive Sciences] Proc. Natl. Acad. Sci. U.S.A. (IF 9.412) Pub Date : 2021-02-09 Emily Kubin, Curtis Puryear, Chelsea Schein, Kurt Gray
Both liberals and conservatives believe that using facts in political discussions helps to foster mutual respect, but 15 studies—across multiple methodologies and issues—show that these beliefs are mistaken. Political opponents respect moral beliefs more when they are supported by personal experiences, not facts. The respect-inducing power of personal experiences is revealed by survey studies across
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Benthic invaders control the phosphorus cycle in the world’s largest freshwater ecosystem [Environmental Sciences] Proc. Natl. Acad. Sci. U.S.A. (IF 9.412) Pub Date : 2021-02-09 Jiying Li, Vadym Ianaiev, Audrey Huff, John Zalusky, Ted Ozersky, Sergei Katsev
The productivity of aquatic ecosystems depends on the supply of limiting nutrients. The invasion of the Laurentian Great Lakes, the world’s largest freshwater ecosystem, by dreissenid (zebra and quagga) mussels has dramatically altered the ecology of these lakes. A key open question is how dreissenids affect the cycling of phosphorus (P), the nutrient that limits productivity in the Great Lakes. We
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Cell-phone traces reveal infection-associated behavioral change [Population Biology] Proc. Natl. Acad. Sci. U.S.A. (IF 9.412) Pub Date : 2021-02-09 Ymir Vigfusson, Thorgeir A. Karlsson, Derek Onken, Congzheng Song, Atli F. Einarsson, Nishant Kishore, Rebecca M. Mitchell, Ellen Brooks-Pollock, Gudrun Sigmundsdottir, Leon Danon
Epidemic preparedness depends on our ability to predict the trajectory of an epidemic and the human behavior that drives spread in the event of an outbreak. Changes to behavior during an outbreak limit the reliability of syndromic surveillance using large-scale data sources, such as online social media or search behavior, which could otherwise supplement healthcare-based outbreak-prediction methods
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