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Seeing Bennu through the eyes of OSIRIS-REx Nat. Astron. (IF 14.1) Pub Date : 2023-09-22 Queenie H. S. Chan
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Astrophysics with continuous gravitational waves Nat. Astron. (IF 14.1) Pub Date : 2023-09-21 B. Haskell, M. Bejger
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Dilution of chemical enrichment in galaxies 600 Myr after the Big Bang Nat. Astron. (IF 14.1) Pub Date : 2023-09-21 Kasper E. Heintz, Gabriel B. Brammer, Clara Giménez-Arteaga, Victoria B. Strait, Claudia del P. Lagos, Aswin P. Vijayan, Jorryt Matthee, Darach Watson, Charlotte A. Mason, Anne Hutter, Sune Toft, Johan P. U. Fynbo, Pascal A. Oesch
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How lasers detect day-length changes of a few milliseconds Nature (IF 64.8) Pub Date : 2023-09-22
Device decades in the making senses very small alterations in Earth’s rotation.
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Earth’s average 2023 temperature is now likely to reach 1.5 °C of warming Nature (IF 64.8) Pub Date : 2023-09-22
But to breach the Paris agreement’s limit, the heating must be sustained for many years.
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Is depression lifting? AI that interprets brain waves has answers Nature (IF 64.8) Pub Date : 2023-09-22
A pattern of brain activity linked with recovery from severe depression could be used to improve therapies such as deep-brain stimulation
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AlphaFold touted as next big thing for drug discovery — but is it? Nature (IF 64.8) Pub Date : 2023-09-22
Questions remain about whether the AI tool for predicting protein structures can really shake up the pharmaceutical industry.
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Proposed law could protect academic freedom across Europe Nature (IF 64.8) Pub Date : 2023-09-22
Some European governments are tightening their political grip on universities, sparking calls for action.
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How to train your jellyfish: brainless box jellies learn from experience Nature (IF 64.8) Pub Date : 2023-09-22
Researchers have shown that the creatures can learn to avoid obstacles using visual and mechanical cues, despite not having a brain.
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Daily briefing: Critics call consciousness theory ‘pseudoscience’ Nature (IF 64.8) Pub Date : 2023-09-21
Artificial intelligence diagnoses and predicts the risk of developing Parkinson’s disease, heart failure and more from images of a person’s retinas. Plus, a ‘Pandora’s box’ of new protein shapes has been discovered and why breast cancer often spreads to the spine.
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Daily briefing: War and weather made Libya floods worse Nature (IF 64.8) Pub Date : 2023-09-18
Artificial intelligence diagnoses and predicts the risk of developing Parkinson’s disease, heart failure and more from images of a person’s retinas. Plus, a ‘Pandora’s box’ of new protein shapes has been discovered and why breast cancer often spreads to the spine.
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Culture clashes: unpicking the power dynamics between research managers and academics Nature (IF 64.8) Pub Date : 2023-09-22
Some researchers thank admin colleagues with chocolates or wine. But deadline pressures, and the need to generate research income, can sometimes result in bullying.
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Vaccine specialist Peter Hotez: scientists are ‘under attack for someone else’s political gain’ Nature (IF 64.8) Pub Date : 2023-09-21
The physician-researcher who spoke out against misinformation during the COVID-19 pandemic says attacks against science are formidable — and getting worse.
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Furry little creatures teem with a multitude of viruses Nature (IF 64.8) Pub Date : 2023-09-20
Large-scale survey reveals the diversity of viruses in small mammals, which can be sources of viruses that hop to humans.
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World recommits to 2030 plan to save humanity — despite falling short so far Nature (IF 64.8) Pub Date : 2023-09-20
United Nations secretary-general António Guterres proposes US$500 billion annual stimulus package to meet the Sustainable Development Goals.
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Cingulate dynamics track depression recovery with deep brain stimulation Nature (IF 64.8) Pub Date : 2023-09-20 Sankaraleengam Alagapan, Ki Sueng Choi, Stephen Heisig, Patricio Riva-Posse, Andrea Crowell, Vineet Tiruvadi, Mosadoluwa Obatusin, Ashan Veerakumar, Allison C. Waters, Robert E. Gross, Sinead Quinn, Lydia Denison, Matthew O’Shaughnessy, Marissa Connor, Gregory Canal, Jungho Cha, Rachel Hershenberg, Tanya Nauvel, Faical Isbaine, Muhammad Furqan Afzal, Martijn Figee, Brian H. Kopell, Robert Butera, Helen
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Synthesis of portimines reveals the basis of their anti-cancer activity Nature (IF 64.8) Pub Date : 2023-09-20 Junchen Tang, Weichao Li, Tzu-Yuan Chiu, Francisco Martínez-Peña, Zengwei Luo, Christine T. Chong, Qijia Wei, Nathalia Gazaniga, Thomas J. West, Yi Yang See, Luke L. Lairson, Christopher G. Parker, Phil S. Baran
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Dual stem-cell populations interact in the skull Nature (IF 64.8) Pub Date : 2023-09-20 Andrei S. Chagin, Dana Trompet
Two types of stem cell produce similar progeny cells in the skull.
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How worlds are born: JWST reveals exotic chemistry of planetary nurseries Nature (IF 64.8) Pub Date : 2023-09-20
The telescope is delivering a cascade of insights about the ‘protoplanetary’ disks where planets take shape.
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Rich countries must align science funding with the SDGs Nature (IF 64.8) Pub Date : 2023-09-20
Research in poorer countries maps closely with the United Nations Sustainable Development Goals — wealthy nations must follow if the goals are to be met.
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The oldest three-dimensionally preserved vertebrate neurocranium Nature (IF 64.8) Pub Date : 2023-09-20 Richard P. Dearden, Agnese Lanzetti, Sam Giles, Zerina Johanson, Andy S. Jones, Stephan Lautenschlager, Emma Randle, Ivan J. Sansom
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Getting inside the oldest known vertebrate skull Nature (IF 64.8) Pub Date : 2023-09-20 Zhikun Gai, Philip C. J. Donoghue
Evolutionary clues from analysis of a 458-million-year-old fossil.
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Consciousness theory slammed as ‘pseudoscience’ — sparking uproar Nature (IF 64.8) Pub Date : 2023-09-20
Researchers publicly call out theory that they say is not well supported by science, but that gets undue attention.
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‘They went to the bar at noon’: what this virtual AI village is teaching researchers Nature (IF 64.8) Pub Date : 2023-09-20
Researcher Joon Park talks about making a small town of AI-powered agents open-source.
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Sympathetic nerves suppress T-cell responses in infection and in cancer Nature (IF 64.8) Pub Date : 2023-09-20
Combination of beta-blockers and immune checkpoint blockade shrinks pancreatic tumours in mice.
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Changing old viticulture for all the right rieslings Nature (IF 64.8) Pub Date : 2023-09-20
Can the French wine industry, built on history and terroir, adapt fast enough to withstand climate change?
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Using CRISPR to study gene function aids understanding of 22q11.2 deletion syndrome Nature (IF 64.8) Pub Date : 2023-09-20
Innovative method for CRISPR screening in vivo provides insights into a syndrome caused by a chromosomal deletion.
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Daily briefing: World’s most powerful X-ray laser will ‘film’ electrical charges hopping around atoms Nature (IF 64.8) Pub Date : 2023-09-20
Artificial intelligence diagnoses and predicts the risk of developing Parkinson’s disease, heart failure and more from images of a person’s retinas. Plus, a ‘Pandora’s box’ of new protein shapes has been discovered and why breast cancer often spreads to the spine.
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The UK’s post-Brexit EU science deal: a graphical guide Nature (IF 64.8) Pub Date : 2023-09-20
Nature explores the United Kingdom and European Union’s research agreements, brokered through seven years of rollercoaster negotiations.
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Why does cancer spread to the spine? Newly discovered stem cells might be the key Nature (IF 64.8) Pub Date : 2023-09-20
Hear the biggest stories from the world of science | 20 September 2023
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These ancient whittled logs could be the earliest known wooden structure Nature (IF 64.8) Pub Date : 2023-09-20
Stacked timbers dated to roughly 476,000 years ago shows that ancient hominins worked with wood.
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Genetic modification can improve crop yields — but stop overselling it Nature (IF 64.8) Pub Date : 2023-09-20 Merritt Khaipho-Burch, Mark Cooper, Jose Crossa, Natalia de Leon, James Holland, Ramsey Lewis, Susan McCouch, Seth C. Murray, Ismail Rabbi, Pamela Ronald, Jeffrey Ross-Ibarra, Detlef Weigel, Edward S. Buckler
With a changing climate and a growing population, the world increasingly needs more-productive and resilient crops. But improving them requires a knowledge of what actually works in the field.
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India: neutralizing temptation by predatory journals Nature (IF 64.8) Pub Date : 2023-09-19
Letter to the Editor
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Tasmanian tiger RNA is first to be recovered from an extinct animal Nature (IF 64.8) Pub Date : 2023-09-19
Genetic sequences from a museum specimen offer fresh clues about the physiology of thylacines, which went extinct in the 1930s.
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Another reason to love remote working: it’s good for the planet Nature (IF 64.8) Pub Date : 2023-09-19
The more people do their jobs from home, the more they cut their greenhouse-gas emissions.
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The secret sex lives of ‘celibate’ stick insects Nature (IF 64.8) Pub Date : 2023-09-19
Genetic analysis shows that some stick insects that supposedly reproduce without sex are actually pairing off to have offspring.
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Bringing space rocks back to Earth could answer some of life’s biggest questions Nature (IF 64.8) Pub Date : 2023-09-19
Safe delivery of samples from an asteroid on 24 September will be the start of a global scientific journey — but similar missions need support.
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AI can help to speed up drug discovery — but only if we give it the right data Nature (IF 64.8) Pub Date : 2023-09-19 Marissa Mock, Suzanne Edavettal, Christopher Langmead, Alan Russell
Artificial-intelligence tools that enable companies to share data about drug candidates while keeping sensitive information safe can unleash the potential of machine learning and cutting-edge lab techniques, for the common good.
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Daily briefing: Alzheimer’s makes brain cells undergo ‘cellular suicide’ Nature (IF 64.8) Pub Date : 2023-09-19
Artificial intelligence diagnoses and predicts the risk of developing Parkinson’s disease, heart failure and more from images of a person’s retinas. Plus, a ‘Pandora’s box’ of new protein shapes has been discovered and why breast cancer often spreads to the spine.
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Why the pandemic treaty risks becoming COVID-19 groundhog day Nature (IF 64.8) Pub Date : 2023-09-19
Talks are stalling, but everyone benefits when the fruits of vaccine and drugs research are shared equitably.
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World’s most powerful X-ray laser will ‘film’ chemical reactions in unprecedented detail Nature (IF 64.8) Pub Date : 2023-09-18
Upgraded laser in California will produce one million X-ray pulses per second to study ultrafast processes at the atomic level.
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Nickelates join the club of high-temperature superconductors Nature (IF 64.8) Pub Date : 2023-09-18 Matthias Hepting
High-temperature superconductivity in a nickel-based compound.
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Waste product from wood finally used to make glue Nature (IF 64.8) Pub Date : 2023-09-18 Charles E. Frazier
How to make a wood adhesive from lignin.
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Recovery of walking after paralysis by regenerating characterized neurons to their natural target region Science (IF 56.9) Pub Date : 2023-09-21 Jordan W. Squair, Marco Milano, Alexandra de Coucy, Matthieu Gautier, Michael A. Skinnider, Nicholas D. James, Newton Cho, Anna Lasne, Claudia Kathe, Thomas H. Hutson, Steven Ceto, Laetitia Baud, Katia Galan, Viviana Aureli, Achilleas Laskaratos, Quentin Barraud, Timothy J. Deming, Richie E. Kohman, Bernard L. Schneider, Zhigang He, Jocelyne Bloch, Michael V. Sofroniew, Gregoire Courtine, Mark A. Anderson
Axon regeneration can be induced across anatomically complete spinal cord injury (SCI), but robust functional restoration has been elusive. Whether restoring neurological functions requires directed regeneration of axons from specific neuronal subpopulations to their natural target regions remains unclear. To address this question, we applied projection-specific and comparative single-nucleus RNA sequencing
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Manipulating mitochondrial electron flow enhances tumor immunogenicity Science (IF 56.9) Pub Date : 2023-09-21 Kailash Chandra Mangalhara, Siva Karthik Varanasi, Melissa A. Johnson, Mannix J. Burns, Gladys R. Rojas, Pau B. Esparza Moltó, Alva G. Sainz, Nimesha Tadepalle, Keene L. Abbott, Gaurav Mendiratta, Dan Chen, Yagmur Farsakoglu, Tenzin Kunchok, Filipe Araujo Hoffmann, Bianca Parisi, Mercedes Rincon, Matthew G. Vander Heiden, Marcus Bosenberg, Diana C. Hargreaves, Susan M. Kaech, Gerald S. Shadel
Although tumor growth requires the mitochondrial electron transport chain (ETC), the relative contribution of complex I (CI) and complex II (CII), the gatekeepers for initiating electron flow, remains unclear. In this work, we report that the loss of CII, but not that of CI, reduces melanoma tumor growth by increasing antigen presentation and T cell–mediated killing. This is driven by succinate-mediated
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Reproductive outcomes after pregnancy-induced displacement of preexisting microchimeric cells Science (IF 56.9) Pub Date : 2023-09-21 Tzu-Yu Shao, Jeremy M. Kinder, Gavin Harper, Giang Pham, Yanyan Peng, James Liu, Emily J. Gregory, Bryan E. Sherman, Yuehong Wu, Alexandra E. Iten, Yueh-Chiang Hu, Abigail E. Russi, John J. Erickson, Hilary Miller-Handley, Sing Sing Way
Pregnancy confers partner-specific protection against complications in future pregnancy that parallel persistence of fetal microchimeric cells (FMcs) in mothers after parturition. We show that preexisting FMcs become displaced by new FMcs during pregnancy and that FMc tonic stimulation is essential for expansion of protective fetal-specific forkhead box P3 (FOXP3)–positive regulatory T cells (T reg
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Solid-solvent processing of ultrathin, highly loaded mixed-matrix membrane for gas separation Science (IF 56.9) Pub Date : 2023-09-21 Guining Chen, Cailing Chen, Yanan Guo, Zhenyu Chu, Yang Pan, Guozhen Liu, Gongping Liu, Yu Han, Wanqin Jin, Nanping Xu
Mixed-matrix membranes (MMMs) that combine processable polymer with more permeable and selective filler have potential for molecular separation, but it remains difficult to control their interfacial compatibility and achieve ultrathin selective layers during processing, particularly at high filler loading. We present a solid-solvent processing strategy to fabricate an ultrathin MMM (thickness less
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Endogenous CO 2 ice mixture on the surface of Europa and no detection of plume activity Science (IF 56.9) Pub Date : 2023-09-21 G. L. Villanueva, H. B. Hammel, S. N. Milam, S. Faggi, V. Kofman, L. Roth, K. P. Hand, L. Paganini, J. Stansberry, J. Spencer, S. Protopapa, G. Strazzulla, G. Cruz-Mermy, C. R. Glein, R. Cartwright, G. Liuzzi
Jupiter’s moon Europa has a subsurface ocean beneath an icy crust. Conditions within the ocean are unknown, and it is unclear whether it is connected to the surface. We observed Europa with the James Webb Space Telescope (JWST) to search for active release of material by probing its surface and atmosphere. A search for plumes yielded no detection of water, carbon monoxide, methanol, ethane, or methane
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Solid-state batteries: The critical role of mechanics Science (IF 56.9) Pub Date : 2023-09-21 Sergiy Kalnaus, Nancy J. Dudney, Andrew S. Westover, Erik Herbert, Steve Hackney
Solid-state batteries with lithium metal anodes have the potential for higher energy density, longer lifetime, wider operating temperature, and increased safety. Although the bulk of the research has focused on improving transport kinetics and electrochemical stability of the materials and interfaces, there are also critical challenges that require investigation of the mechanics of materials. In batteries
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The distribution of CO 2 on Europa indicates an internal source of carbon Science (IF 56.9) Pub Date : 2023-09-21 Samantha K. Trumbo, Michael E. Brown
Jupiter’s moon Europa has a subsurface ocean, the chemistry of which is largely unknown. Carbon dioxide (CO 2 ) has previously been detected on the surface of Europa, but it was not possible to determine whether it originated from subsurface ocean chemistry, was delivered by impacts, or was produced on the surface by radiation processing of impact-delivered material. We mapped the distribution of CO
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A regional approach to save the Amazon Science (IF 56.9) Pub Date : 2023-09-21 Marielos Peña-Claros, Carlos Nobre
Early in August this year, a high-profile summit was held in Belém, Brazil, where the eight Amazonian countries discussed the future of the Amazon. The nations recognized that the Amazon is very close to reaching a tipping point for turning into a degraded ecosystem. The result of their discussions was the Belém Declaration, an ambitious plan to protect and conserve the Amazon forests and to support
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Reducing cartel recruitment is the only way to lower violence in Mexico Science (IF 56.9) Pub Date : 2023-09-21 Rafael Prieto-Curiel, Gian Maria Campedelli, Alejandro Hope
Mexican cartels lose many members as a result of conflict with other cartels and incarcerations. Yet, despite their losses, cartels manage to increase violence for years. We address this puzzle by leveraging data on homicides, missing persons, and incarcerations in Mexico for the past decade along with information on cartel interactions. We model recruitment, state incapacitation, conflict, and saturation
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Mother Nature’s playground: Sometimes in the wild it is all about fun Science (IF 56.9) Pub Date : 2023-09-21 Terrie M. Williams
From surfboard-stealing sea otters to sailboat-chomping killer whales, the summer of 2023 was a landmark year of wild animal antics. Why is wildlife suddenly interacting with humans and their toys in this way? Speculation and headlines have espoused theories about learned behaviors due to enticements with food, increased intrusion, and proximity of humans in wild habitats, as well as aberrant animal
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Impacts of metal mining on river systems: a global assessment Science (IF 56.9) Pub Date : 2023-09-21 M. G. Macklin, C. J. Thomas, A. Mudbhatkal, P. A. Brewer, K. A. Hudson-Edwards, J. Lewin, P. Scussolini, D. Eilander, A. Lechner, J. Owen, G. Bird, D. Kemp, K. R. Mangalaa
An estimated 23 million people live on floodplains affected by potentially dangerous concentrations of toxic waste derived from past and present metal mining activity. We analyzed the global dimensions of this hazard, particularly in regard to lead, zinc, copper, and arsenic, using a georeferenced global database detailing all known metal mining sites and intact and failed tailings storage facilities
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Short tandem repeats bind transcription factors to tune eukaryotic gene expression Science (IF 56.9) Pub Date : 2023-09-21 Connor A. Horton, Amr M. Alexandari, Michael G. B. Hayes, Emil Marklund, Julia M. Schaepe, Arjun K. Aditham, Nilay Shah, Peter H. Suzuki, Avanti Shrikumar, Ariel Afek, William J. Greenleaf, Raluca Gordân, Julia Zeitlinger, Anshul Kundaje, Polly M. Fordyce
Short tandem repeats (STRs) are enriched in eukaryotic cis -regulatory elements and alter gene expression, yet how they regulate transcription remains unknown. We found that STRs modulate transcription factor (TF)–DNA affinities and apparent on-rates by about 70-fold by directly binding TF DNA-binding domains, with energetic impacts exceeding many consensus motif mutations. STRs maximize the number
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Disequilibrating azobenzenes by visible-light sensitization under confinement Science (IF 56.9) Pub Date : 2023-09-21 Julius Gemen, Jonathan R. Church, Tero-Petri Ruoko, Nikita Durandin, Michał J. Białek, Maren Weißenfels, Moran Feller, Miri Kazes, Magdalena Odaybat, Veniamin A. Borin, Rishir Kalepu, Yael Diskin-Posner, Dan Oron, Matthew J. Fuchter, Arri Priimagi, Igor Schapiro, Rafal Klajn
Photoisomerization of azobenzenes from their stable E isomer to the metastable Z state is the basis of numerous applications of these molecules. However, this reaction typically requires ultraviolet light, which limits applicability. In this study, we introduce disequilibration by sensitization under confinement (DESC), a supramolecular approach to induce the E -to- Z isomerization by using light of
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Structural basis for inactivation of PRC2 by G-quadruplex RNA Science (IF 56.9) Pub Date : 2023-09-21 Jiarui Song, Anne R. Gooding, Wayne O. Hemphill, Brittney D. Love, Anne Robertson, Liqi Yao, Leonard I. Zon, Trista E. North, Vignesh Kasinath, Thomas R. Cech
Polycomb repressive complex 2 (PRC2) silences genes through trimethylation of histone H3K27. PRC2 associates with numerous precursor messenger RNAs (pre-mRNAs) and long noncoding RNAs (lncRNAs) with a binding preference for G-quadruplex RNA. In this work, we present a 3.3-Å-resolution cryo–electron microscopy structure of PRC2 bound to a G-quadruplex RNA. Notably, RNA mediates the dimerization of PRC2
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Global effects of marine protected areas on food security are unknown Nature (IF 64.8) Pub Date : 2023-09-20 Daniel Ovando, Owen Liu, Renato Molina, Ana Parma, Cody Szuwalski
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For Health Equity, Location Matters Nature (IF 64.8) Pub Date : 2023-09-20
A special package explores problems and solutions to the geography of injustice.
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A crystalline doubly oxidized carbene Nature (IF 64.8) Pub Date : 2023-09-20 Ying Kai Loh, Mohand Melaimi, Milan Gembicky, Dominik Munz, Guy Bertrand