Device decades in the making senses very small alterations in Earth’s rotation.

But to breach the Paris agreement’s limit, the heating must be sustained for many years.

A pattern of brain activity linked with recovery from severe depression could be used to improve therapies such as deep-brain stimulation

Questions remain about whether the AI tool for predicting protein structures can really shake up the pharmaceutical industry.

Some European governments are tightening their political grip on universities, sparking calls for action.

Researchers have shown that the creatures can learn to avoid obstacles using visual and mechanical cues, despite not having a brain.

Artificial intelligence diagnoses and predicts the risk of developing Parkinson’s disease, heart failure and more from images of a person’s retinas. Plus, a ‘Pandora’s box’ of new protein shapes has been discovered and why breast cancer often spreads to the spine.

Artificial intelligence diagnoses and predicts the risk of developing Parkinson’s disease, heart failure and more from images of a person’s retinas. Plus, a ‘Pandora’s box’ of new protein shapes has been discovered and why breast cancer often spreads to the spine.

Some researchers thank admin colleagues with chocolates or wine. But deadline pressures, and the need to generate research income, can sometimes result in bullying.

The physician-researcher who spoke out against misinformation during the COVID-19 pandemic says attacks against science are formidable — and getting worse.

Large-scale survey reveals the diversity of viruses in small mammals, which can be sources of viruses that hop to humans.

United Nations secretary-general António Guterres proposes US$500 billion annual stimulus package to meet the Sustainable Development Goals.

Two types of stem cell produce similar progeny cells in the skull.

The telescope is delivering a cascade of insights about the ‘protoplanetary’ disks where planets take shape.

Research in poorer countries maps closely with the United Nations Sustainable Development Goals — wealthy nations must follow if the goals are to be met.

Evolutionary clues from analysis of a 458-million-year-old fossil.

Researchers publicly call out theory that they say is not well supported by science, but that gets undue attention.

Researcher Joon Park talks about making a small town of AI-powered agents open-source.

Combination of beta-blockers and immune checkpoint blockade shrinks pancreatic tumours in mice.

Can the French wine industry, built on history and terroir, adapt fast enough to withstand climate change?

Innovative method for CRISPR screening in vivo provides insights into a syndrome caused by a chromosomal deletion.

Artificial intelligence diagnoses and predicts the risk of developing Parkinson’s disease, heart failure and more from images of a person’s retinas. Plus, a ‘Pandora’s box’ of new protein shapes has been discovered and why breast cancer often spreads to the spine.

Nature explores the United Kingdom and European Union’s research agreements, brokered through seven years of rollercoaster negotiations.

Hear the biggest stories from the world of science | 20 September 2023

Stacked timbers dated to roughly 476,000 years ago shows that ancient hominins worked with wood.

With a changing climate and a growing population, the world increasingly needs more-productive and resilient crops. But improving them requires a knowledge of what actually works in the field.

Letter to the Editor

Genetic sequences from a museum specimen offer fresh clues about the physiology of thylacines, which went extinct in the 1930s.

The more people do their jobs from home, the more they cut their greenhouse-gas emissions.

Genetic analysis shows that some stick insects that supposedly reproduce without sex are actually pairing off to have offspring.

Safe delivery of samples from an asteroid on 24 September will be the start of a global scientific journey — but similar missions need support.

Artificial-intelligence tools that enable companies to share data about drug candidates while keeping sensitive information safe can unleash the potential of machine learning and cutting-edge lab techniques, for the common good.

Artificial intelligence diagnoses and predicts the risk of developing Parkinson’s disease, heart failure and more from images of a person’s retinas. Plus, a ‘Pandora’s box’ of new protein shapes has been discovered and why breast cancer often spreads to the spine.

Talks are stalling, but everyone benefits when the fruits of vaccine and drugs research are shared equitably.

Upgraded laser in California will produce one million X-ray pulses per second to study ultrafast processes at the atomic level.

High-temperature superconductivity in a nickel-based compound.

How to make a wood adhesive from lignin.

Axon regeneration can be induced across anatomically complete spinal cord injury (SCI), but robust functional restoration has been elusive. Whether restoring neurological functions requires directed regeneration of axons from specific neuronal subpopulations to their natural target regions remains unclear. To address this question, we applied projection-specific and comparative single-nucleus RNA sequencing

Although tumor growth requires the mitochondrial electron transport chain (ETC), the relative contribution of complex I (CI) and complex II (CII), the gatekeepers for initiating electron flow, remains unclear. In this work, we report that the loss of CII, but not that of CI, reduces melanoma tumor growth by increasing antigen presentation and T cell–mediated killing. This is driven by succinate-mediated

Pregnancy confers partner-specific protection against complications in future pregnancy that parallel persistence of fetal microchimeric cells (FMcs) in mothers after parturition. We show that preexisting FMcs become displaced by new FMcs during pregnancy and that FMc tonic stimulation is essential for expansion of protective fetal-specific forkhead box P3 (FOXP3)–positive regulatory T cells (T reg

Mixed-matrix membranes (MMMs) that combine processable polymer with more permeable and selective filler have potential for molecular separation, but it remains difficult to control their interfacial compatibility and achieve ultrathin selective layers during processing, particularly at high filler loading. We present a solid-solvent processing strategy to fabricate an ultrathin MMM (thickness less

Jupiter’s moon Europa has a subsurface ocean beneath an icy crust. Conditions within the ocean are unknown, and it is unclear whether it is connected to the surface. We observed Europa with the James Webb Space Telescope (JWST) to search for active release of material by probing its surface and atmosphere. A search for plumes yielded no detection of water, carbon monoxide, methanol, ethane, or methane

Solid-state batteries with lithium metal anodes have the potential for higher energy density, longer lifetime, wider operating temperature, and increased safety. Although the bulk of the research has focused on improving transport kinetics and electrochemical stability of the materials and interfaces, there are also critical challenges that require investigation of the mechanics of materials. In batteries

Jupiter’s moon Europa has a subsurface ocean, the chemistry of which is largely unknown. Carbon dioxide (CO 2 ) has previously been detected on the surface of Europa, but it was not possible to determine whether it originated from subsurface ocean chemistry, was delivered by impacts, or was produced on the surface by radiation processing of impact-delivered material. We mapped the distribution of CO

Early in August this year, a high-profile summit was held in Belém, Brazil, where the eight Amazonian countries discussed the future of the Amazon. The nations recognized that the Amazon is very close to reaching a tipping point for turning into a degraded ecosystem. The result of their discussions was the Belém Declaration, an ambitious plan to protect and conserve the Amazon forests and to support

Mexican cartels lose many members as a result of conflict with other cartels and incarcerations. Yet, despite their losses, cartels manage to increase violence for years. We address this puzzle by leveraging data on homicides, missing persons, and incarcerations in Mexico for the past decade along with information on cartel interactions. We model recruitment, state incapacitation, conflict, and saturation

From surfboard-stealing sea otters to sailboat-chomping killer whales, the summer of 2023 was a landmark year of wild animal antics. Why is wildlife suddenly interacting with humans and their toys in this way? Speculation and headlines have espoused theories about learned behaviors due to enticements with food, increased intrusion, and proximity of humans in wild habitats, as well as aberrant animal

An estimated 23 million people live on floodplains affected by potentially dangerous concentrations of toxic waste derived from past and present metal mining activity. We analyzed the global dimensions of this hazard, particularly in regard to lead, zinc, copper, and arsenic, using a georeferenced global database detailing all known metal mining sites and intact and failed tailings storage facilities

Short tandem repeats (STRs) are enriched in eukaryotic cis -regulatory elements and alter gene expression, yet how they regulate transcription remains unknown. We found that STRs modulate transcription factor (TF)–DNA affinities and apparent on-rates by about 70-fold by directly binding TF DNA-binding domains, with energetic impacts exceeding many consensus motif mutations. STRs maximize the number

Photoisomerization of azobenzenes from their stable E isomer to the metastable Z state is the basis of numerous applications of these molecules. However, this reaction typically requires ultraviolet light, which limits applicability. In this study, we introduce disequilibration by sensitization under confinement (DESC), a supramolecular approach to induce the E -to- Z isomerization by using light of

Polycomb repressive complex 2 (PRC2) silences genes through trimethylation of histone H3K27. PRC2 associates with numerous precursor messenger RNAs (pre-mRNAs) and long noncoding RNAs (lncRNAs) with a binding preference for G-quadruplex RNA. In this work, we present a 3.3-Å-resolution cryo–electron microscopy structure of PRC2 bound to a G-quadruplex RNA. Notably, RNA mediates the dimerization of PRC2

A special package explores problems and solutions to the geography of injustice.