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Neurotransmitter Readily Escapes Detection at the Opposing Microelectrode Surface in Typical Amperometric Measurements of Exocytosis at Single Cells Anal. Chem. (IF 6.986) Pub Date : 2022-06-24 Gregory S. McCarty, Lars E. Dunaway, J. Dylan Denison, Leslie A. Sombers
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Plasmon-Boosted Fe, Co Dual Single-Atom Catalysts for Ultrasensitive Luminol-Dissolved O2 Electrochemiluminescence Detection of Prostate-Specific Antigen Anal. Chem. (IF 6.986) Pub Date : 2022-06-24 Fuad Abduro Bushira, Ping Wang, Yong Wang, Shuping Hou, Xingkang Diao, Haijuan Li, Lirong Zheng, Yongdong Jin
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Highly Efficient Isolation and Sensitive Detection of Small Extracellular Vesicles Using a Paper-Based Device Anal. Chem. (IF 6.986) Pub Date : 2022-06-24 Lang Zhang, Wen Yin, Yanli Tong, Yanfei Zhang, Yuzhi Xu, Si-Yang Liu, Zong Dai, Xiaoyong Zou
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Zinc–Air Battery-Assisted Self-Powered PEC Sensors for Sensitive Assay of PTP1B Activity Based on Perovskite Quantum Dots Encapsulated in Vinyl-Functionalized Covalent Organic Frameworks Anal. Chem. (IF 6.986) Pub Date : 2022-06-24 Ke Xiao, Rong Zhu, Cuicui Du, Hejie Zheng, Xiaohua Zhang, Jinhua Chen
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A Novel PNGase Rc for Improved Protein N-Deglycosylation in Bioanalytics and Hydrogen–Deuterium Exchange Coupled With Mass Spectrometry Epitope Mapping under Challenging Conditions Anal. Chem. (IF 6.986) Pub Date : 2022-06-24 Marius Gramlich, Sandra Maier, Philipp D. Kaiser, Bjoern Traenkle, Teresa R. Wagner, Josef Voglmeir, Dieter Stoll, Ulrich Rothbauer, Anne Zeck
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Discrimination between Cancer Cells and DNA-Damaged Cells: Pre-miRNA Region Recognition Based on Hyperbranched Hybrid Chain Reaction Amplification for Simultaneous Sensitive Detection and Imaging of miRNA and Pre-miRNA Anal. Chem. (IF 6.986) Pub Date : 2022-06-24 Jie Zhou, Xin Peng, Zezhou Yang, Ying Zhuo, Wenbin Liang, Ruo Yuan, Yaqin Chai
Herein, a novel region recognition of precursor microRNA (Pre-miRNA) based on hyperbranched hybrid chain reaction (HB-HCR) amplification was constructed to effectively eliminate the interference of Pre-miRNA to the mature microRNA (miRNA) by establishing the linear mapping relation between the two fluorescence signals produced by the miRNA sequence in the Pre-miRNA and Pre-miRNA residues to first realize
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Hairpin Structure Facilitates Multiplex High-Fidelity DNA Amplification in Real-Time Polymerase Chain Reaction Anal. Chem. (IF 6.986) Pub Date : 2022-06-24 Kerou Zhang, Alessandro Pinto, Lauren Yuxuan Cheng, Ping Song, Peng Dai, Michael Wang, Luis Rodriguez, Cailin Weller, David Yu Zhang
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Engineering Phage Tail Fiber Protein as a Wide-Spectrum Probe for Acinetobacter baumannii Strains with a Recognition Rate of 100% Anal. Chem. (IF 6.986) Pub Date : 2022-06-24 Ying Chen, Honglin Yang, Shuai Luo, Lin Wang, Shuguang Lu, Zhifeng Fu
As a multidrug-resistant pathogen, Acinetobacter baumannii has long been identified as one of the most common nosocomial bacteria. High-performance recognition probes for wide-spectrum detection of A. baumannii are highly desired to achieve efficient diagnosis and timely treatment of infectious diseases induced by this pathogen. An engineering tail fiber protein (ETFP) named as Gp50 encoded by lytic
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Hydroxymethylation-Specific Ligation-Mediated Single Quantum Dot-Based Nanosensors for Sensitive Detection of 5-Hydroxymethylcytosine in Cancer Cells Anal. Chem. (IF 6.986) Pub Date : 2022-06-24 Zi-yue Wang, Huimin Yuan, Dong-ling Li, Juan Hu, Jian-Ge Qiu, Chun-yang Zhang
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Rapid Identification and Classification of Pathogens That Produce Carbapenemases and Cephalosporinases with a Colorimetric Paper-Based Multisensor Anal. Chem. (IF 6.986) Pub Date : 2022-06-24 Giulia Santopolo, Antonio Clemente, Estrella Rojo-Molinero, Antonio Oliver, Camilla Noé, Roberto de la Rica
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Band-Edge Effect-Induced Electrochemiluminescence Signal Amplification Based on Inverse Opal Photonic Crystals for Ultrasensitive Detection of Carcinoembryonic Antigen Anal. Chem. (IF 6.986) Pub Date : 2022-06-24 Xin Zhang, Zhong-Jie Wang, Xu Wang, Ya-Heng Zhang, Jian Qu, Shou-Nian Ding
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Size-Discriminative DNA Nanocage Framework Enables Sensitive and High-Fidelity Imaging of Mature MicroRNA in Living Cells Anal. Chem. (IF 6.986) Pub Date : 2022-06-24 Xia Li, Fang Yang, Shunmei Li, Ruo Yuan, Yun Xiang
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Fentanyl Assay Derived from Intermolecular Interaction-Enabled Small Molecule Recognition (iMSR) with Differential Impedance Analysis for Point-of-Care Testing Anal. Chem. (IF 6.986) Pub Date : 2022-06-23 Zhe Wang, Amit Nautiyal, Christopher Alexopoulos, Rania Aqrawi, Xiaozhou Huang, Ashraf Ali, Katherine E. Lawson, Kevin Riley, Andrew J. Adamczyk, Pei Dong, Xinyu Zhang
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Use of Diethanolamine as a Viscous Solvent for Mixture Analysis by Multidimensional Heteronuclear ViscY NMR Experiments Anal. Chem. (IF 6.986) Pub Date : 2022-06-23 Ritchy Leroy, Francois Pedinielli, Gautier Bourbon, Jean-Marc Nuzillard, Pedro Lameiras
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O-Fluorobenzoic Acid-Mediated Construction of Porous Graphitic Carbon Nitride with Nitrogen Defects for Multicolor Electrochemiluminescence Imaging Sensing Anal. Chem. (IF 6.986) Pub Date : 2022-06-23 Fang Li, Yachao Xi, Jianming Jiang, Hao Peng, Bing Li, Jianbo He, Jiangnan Shu, Hua Cui
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NH3 Plasma Functionalization of UiO-66-NH2 for Highly Enhanced Selective Fluorescence Detection of U(VI) in Water Anal. Chem. (IF 6.986) Pub Date : 2022-06-23 Jiali Liu, Xianbiao Wang, Yangyang Zhao, Yongfei Xu, Yang Pan, Shaojie Feng, Jin Liu, Xianhuai Huang, Huanting Wang
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Dissolved Oxygen-Sensing Chip Integrating an Open Container Connected with a Position-Raised Channel for Estimation of Cellular Mitochondrial Activity ACS Sens. (IF 7.711) Pub Date : 2022-06-24 Ching-Chou Wu, Chieh-Jen Wang, Cicero Lee-Tian Chang, Hitoshi Shiku, Yu-Ren Wang, Jia-De Yan, Shinn-Jyh Ding
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Active W Sites Promoted by Defect Engineering Enhanced C2H6S3 Sensing Performance of WO3 Nanosheets ACS Sens. (IF 7.711) Pub Date : 2022-06-23 Xiafen Hu, Xiang Li, Huimin Yang, Chengjia Xu, Weiqiang Xiong, Xiang Guo, Changsheng Xie, Dawen Zeng
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A Supported Lipid Bilayer-Based Lab-on-a-Chip Biosensor for the Rapid Electrical Screening of Coronavirus Drugs ACS Sens. (IF 7.711) Pub Date : 2022-06-23 Feng Zhou, Wenwei Pan, Ye Chang, Xueyou Su, Xuexin Duan, Qiannan Xue
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A Simple Counting-Based Measurement for Paper Analytical Devices and Their Application ACS Sens. (IF 7.711) Pub Date : 2022-06-23 Kawin Khachornsakkul, Danai Phuengkasem, Kitiya Palkuntod, Wuttichai Sangkharoek, Opor Jamjumrus, Wijitar Dungchai
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The Benefit of Being Gracious ACS Sens. (IF 7.711) Pub Date : 2022-06-24 Maarten Merkx
While replication is important in establishing scientific knowledge, novelty is typically regarded more highly when it comes to scientific publishing. In fact, the importance of originality is also reflected in the scope of ACS Sensors, which reads: “ACS Sensors is a peer-reviewed research journal that is devoted to the dissemination of new and original knowledge on all aspects of sensor science that
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A simple ultrasensitive electrochemical detection of DBP plasticizer for the risk assessment of the South Korean River water Analyst (IF 4.616) Pub Date : 2022-06-24 N G Gurudatt, Kyungyeon Lee, Woong Heo, Hyo-il Jung
Rapid detection of contaminants for the purpose of sensitive and quantitative monitoring of environmental hazards is an essential first step in realizing the avoidance of human health risks. In this regard, we present a fast and simple electrochemical method of detecting di-n-butyl phthalate (DBP) from the river water samples using a phthalic acid group specific aptamer modified on a gold nanoparticle
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Electrocatalytic Detection of Ethanol and Acetaldehyde by Aminoxyl Radicals: Utilizing Molecular Catalysis for Breath Analysis Analyst (IF 4.616) Pub Date : 2022-06-24 Mikayla N Mayer, Mohammad Rafiee
Herein, the insights gleaned from mechanistic studies of aminoxyl catalyzed oxidation of alcohols and aldehydes were used for fabrication of a gas phase sensor for ethanol and acetaldehyde. This electrochemical sensor consists of an aminoxyl radical and graphene oxide that its response and selectivity can be altered by tuning the basicity of the graphene oxide.
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Living algae Detection with a PDMS-Liquid Chlorophyll Fluorescence Filter and a Smartphone in a Microfluidic Chip Analyst (IF 4.616) Pub Date : 2022-06-23 Jianhua Liu, Hui Chang, Xiangyu Zhang, Shimeng Chen, Yongxin Song, Dongqing Li
Building the optical filtration function into a microfluidic chip is a promising way for simplifying the optical detection system of a microfluidic device. In this paper, a PDMS microfluidic chip filter that is capable of transmitting chlorophyll fluorescence and blocking interfering light in the visible wavelength range was developed for living algae detection with a smartphone. The chip was fabricated
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Construction of dPCR and qPCR Integrated System Based on Commercially Available Low-Cost Hardware Analyst (IF 4.616) Pub Date : 2022-06-23 Kangning Wang, Benliang Sang, Limin He, Yu Guo, Mingkun Geng, Dezhou Zheng, xiaolong Xu, Wenming Wu
Fluorescent quantitative PCR (qPCR) and digital PCR (dPCR) are two mainstream nucleic acid quantification technologies. However, commercial dPCR and qPCR in-struments have a low integration, a high price, and a large footprint. To solve these shortcomings, we introduce a compound PCR system with both qPCR and dPCR func-tions. All the hardware used in this compound PCR system is commercially available
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3D Printed Microfluidic Coulter Counter for Blood Cell Analysis Analyst (IF 4.616) Pub Date : 2022-06-23 Jiasheng Yan, Chuang Wang, Yusheng Fu, Jiuchuan Guo, Jinhong Guo
Coulter counters are ubiquitous in everyday life; however, with reduced orifice size shrinkage, there is an increased risk of clogging. Herein, a 3D microfluidic printing-based single-use kit is presented for analyzing biological samples and performing accurate Coulter cell count analysis (e.g., white blood cells in blood). The gem hole eliminates the traditional design concept of integration inside
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Sensitive and rapid determination of heat shock proteins 70 using lateral flow immunostrips and upconversion nanoparticle fluorescence probes Analyst (IF 4.616) Pub Date : 2022-06-23 nengying Wu, Yuxi Wei, lanlan pan, xiaolin yang, Honglan Qi, Qiang Gao, Chengxiao Zhang, Chenzhong Li
Heat shock proteins70 (Hsp70), belonging to heat shock proteins (HSPs), is reported to be a potential diagnostic biomarker. In this work, a lateral flow immunostrip was fabricated for sensitive and rapid determination of Hsp70 by the incorporation of fluorescence technique and upconversion nanoparticles probe. The upconversion nanoparticles (UCNP, size ~39 nm, λex=980 nm; λem=540 nm) consisting of
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A review on conjugated polymer-based electronic tongues Anal. Chim. Acta (IF 6.558) Pub Date : 2022-06-24 Parastoo Vahdatiyekta, Mohammed Zniber, Johan Bobacka, Tan-Phat Huynh
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A whole-thermoplastic microfluidic chip with integrated on-chip micropump, bioreactor and oxygenator for cell culture applications Anal. Chim. Acta (IF 6.558) Pub Date : 2022-06-24 Amir Reza Ameri, Armin Imanparast, Mohammad Passandideh-Fard, Seyed Ali Mousavi Shaegh
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2H–MoS2/Co3O4 nanohybrid with type I nitroreductase-mimicking activity for the electrochemical assays of nitroaromatic compounds Anal. Chim. Acta (IF 6.558) Pub Date : 2022-06-23 Yujie Ma, Mingshi Deng, Xuefeng Wang, Xinghua Gao, Haixiang Song, Yongheng Zhu, Lingyan Feng, Yuan Zhang
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Dual-mode colorimetric determination of As(III) based on negatively-charged aptamer-mediated aggregation of positively-charged AuNPs Anal. Chim. Acta (IF 6.558) Pub Date : 2022-06-23 Dongwei Zhang, Shaohua Chu, Lumei Wang, Xuejia Zhan, Pei Zhou, Dan Zhang
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Label-free hairpin probe for the rapid detection of Hg(II) based on T-Hg(II)-T Anal. Chim. Acta (IF 6.558) Pub Date : 2022-06-23 Xiaochuan Jin, Ting Sun, Ziyi Wu, Deyong Wang, Fan Hu, Jiaxuan Xu, Xian Li, Jieqiong Qiu
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Determination of trace metal ions in Gentiana rigescens by inductively coupled plasma-optical emission spectrometry after deep eutectic solvent-based digestion and related pharmacodynamic evaluation Anal. Chim. Acta (IF 6.558) Pub Date : 2022-06-23 Xiaofang Yang, Caixia Yan, Rui Zhang, Yiping Sun, Zhengui Li, Yong Liu, Shengchun Yang, Lei Shen, Xiaodong Wen
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A highly water-stable dual-emission fluorescent probe based on Eu3+-loaded MOF for the simultaneous detection and quantification of Fe3+ and Al3+ in swine wastewater Anal. Chim. Acta (IF 6.558) Pub Date : 2022-06-23 Yi-Fan Xia, Guang-Ming Bao, Xiong-Xin Peng, Xin-Yu Wu, Hui-Fang Lu, Yu-Fei Zhong, Wei Li, Jia-Xin He, Si-Yi Liu, Qing Fan, Si-Han Li, Wei Xiao, Hou-Qun Yuan
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Quantitative and direct serum albumin detection by label-free SERS using tunable hydroxyapatite nanostructure for prostate cancer detection Anal. Chim. Acta (IF 6.558) Pub Date : 2022-06-21 Yamin Lin, Juqiang Lin, Mengmeng Zheng, Wei Gong, Huan Li, Zhengyu Shu, Weiwei Du, Siqi Gao, Yun Yu
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In situ encapsulation of SQDs by zinc ion-induced ZIF-8 growth strategy for fluorescent and colorimetric dual-signal detection of alkaline phosphatase Anal. Chim. Acta (IF 6.558) Pub Date : 2022-06-20 Xiao-Xue Jiang, Pan Li, Meng-Ya Zhao, Rui-Cong Chen, Zhen-Guang Wang, Jia-Xiu Xie, Yun-Kai Lv
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Ultrasensitive sensing of T4 PNK phosphatase activity through establishing a novel transcription-based signal amplification platform Sens. Actuators B Chem. (IF 7.46) Pub Date : 2022-06-24 Ran Luo, Guowei Lian, Hengxuan Li, Houyu Han, Dianming Zhou, Xiaoqun Gong
Signal amplification plays a significant role in nucleic acid analysis, especially in trace nucleic acid detection. Transcription-based signal amplification is a very important component in the field of signal amplification, and has received extensive attention depending on outstanding cyclic transcription ability. However, the low efficiency of transcription caused by limited template length usually
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In-situ polymerization of dendritic polyaniline nanofibers network embedded with Ag@SiO2 core-shell nanoparticles for electrochemical determination of trace arsenic(III) Sens. Actuators B Chem. (IF 7.46) Pub Date : 2022-06-22 Tong Feng, Kaicha Chen, Jiamiao Zhong, Yaxin Cheng, Hongli Zhao, Minbo Lan
Arsenic(III) is a highly toxic pollutant in the environment, and the development of nanomaterials with high electrochemical activity for As(III) detection is a research focus at present. Herein, an electrochemical sensing platform based on polyaniline nanofibers embedded with Ag@SiO2 nanoparticles (Ag@SiO2/PANI NFs) was successfully constructed for trace As(III) determination. Owing to an in-situ chemical
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Mitochondria/RNA cascade-targeted and fluorescence-switchable photosensitizer for photodynamic therapy augmentation and real-time efficacy self-monitoring Sens. Actuators B Chem. (IF 7.46) Pub Date : 2022-06-20 Guofen Song, Lei Yan, Qing Liao, Wanling Chen, Liping Tong, Yi Zeng, Paul K. Chu, Penghui Li, Huaiyu Wang
The localization of photosensitizers and timely efficacy evaluation highly affect efficiency of photodynamic therapy (PDT) and the resistance of residual tumor cells. Mitochondria-targeted PDT is an effective modality; however, it may encounter certain resistance caused by autophagy, a cytoprotective manner competing with cell apoptosis. Mitochondria and RNA interact closely in cell apoptosis and autophagy
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On-site detection of multiple extracellular antibiotic resistance genes using SERS Sens. Actuators B Chem. (IF 7.46) Pub Date : 2022-06-21 Shaoyu Lu, Zhipeng Yin, Lixin Zhang, Jingjing Du, Chuanyong Jing
Extracellular antibiotic resistance genes (eARGs) exacerbate the propagation of antimicrobial resistance in the environment and pose great threats to human health. On-site identification and quantification of multiple eARGs at trace level are an urgent need. Herein, we designed a core-satellite platform based on surface enhanced Raman scattering (SERS) to simultaneously detect multiple eARGs (sul1
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A novel split-type photoelectrochemical biosensor based on double-strand specific nuclease-assisted cycle amplification coupled with plasmonic Ag enhanced BiVO4 performance for sensitive detection of microRNA-155 Sens. Actuators B Chem. (IF 7.46) Pub Date : 2022-06-21 Yu-Yang Wei, Shao-Hua Wu, Qi-Meng Wang, Jian-Jun Sun
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Simultaneous measurement of salinity and temperature based on Fabry-Perot interference and anti-resonance effect Sens. Actuators B Chem. (IF 7.46) Pub Date : 2022-06-21 Jian Zhao, Yong Zhao, Yun Peng, Zi-ting Lin, Xu-guang Hu
In this work, we demonstrate a novel cascaded fiber-optic structure depending on Fabry-Perot interference and anti-resonance (AR) effect for seawater salinity and temperature simultaneous measurement. An in-fiber microchannel Fabry-Perot interferometer (FPI) is obtained in a single-mode fiber (SMF) by using femtosecond laser radiation and hydrofluoric acid corrosion, which is filled with thermosensitive
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Surface oxygen vacancies actuated MoO3/CuMoO4 self-assembled microspheres for highly selective triethylamine detection Sens. Actuators B Chem. (IF 7.46) Pub Date : 2022-06-21 Jia Guo, Hang Li, Qian Ma, Qi Zhang, Yi Wang, Xueying Wang
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Human 2D Crypt Model for Assaying Intestinal Stem Cell Proliferation and Differentiation Anal. Chem. (IF 6.986) Pub Date : 2022-06-23 Yuli Wang, Christopher E. Sims, Nancy L. Allbritton
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Separation and Collision Cross Section Measurements of Protein Complexes Afforded by a Modular Drift Tube Coupled to an Orbitrap Mass Spectrometer Anal. Chem. (IF 6.986) Pub Date : 2022-06-23 Sarah N. Sipe, James D. Sanders, Tobias Reinecke, Brian H. Clowers, Jennifer S. Brodbelt
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Single-Atom Iron Enables Strong Low-Triggering-Potential Luminol Cathodic Electrochemiluminescence Anal. Chem. (IF 6.986) Pub Date : 2022-06-23 Wenling Gu, Xiaosi Wang, Mengzhen Xi, Xiaoqian Wei, Lei Jiao, Ying Qin, Jiajia Huang, Xiaowen Cui, Lirong Zheng, Liuyong Hu, Chengzhou Zhu
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Electromembrane Extraction and Dual-Channel Nanoelectrospray Ionization Coupled with a Miniature Mass Spectrometer: Incorporation of a Dicationic Ionic Liquid-Induced Charge Inversion Strategy Anal. Chem. (IF 6.986) Pub Date : 2022-06-23 Meng Chen, Yuhan Shang, Hua Bai, Qiang Ma
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Contactless Photoelectrochemical Biosensor Based on the Ultraviolet–Assisted Gas Sensing Interface of Three-Dimensional SnS2 Nanosheets: From Mechanism Reveal to Practical Application Anal. Chem. (IF 6.986) Pub Date : 2022-06-23 Lingting Huang, Guoneng Cai, Ruijin Zeng, Zhichao Yu, Dianping Tang
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Flow metering for microfluidics: from concept to market, a review Lab Chip (IF 6.799) Pub Date : 2022-06-23 Charles Cavaniol, William César, Stephanie Descroix, Jean-Louis Viovy
Originally designed for chromatography, electrophoresis and printing technologies, microfluidics has found since then its applications in a variety of domain such as engineering, chemistry, environmental or life science.The fundamental underpinning for this expansion has been the development of miniature components allowing the handling of liquids at microscales. During the maturation of microfluidic
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Engineering a sustainable future for point-of-care diagnostic and single-use microfluidic devices Lab Chip (IF 6.799) Pub Date : 2022-06-23 Alfredo Edoardo Ongaro, Zibusiso Ndlovu, Elodie Sollier, Collins Otieno, Pascale Ondoa, Alice Street, Maïwenn Kersaudy-Kerhoas
Single-use, disposable, point-of-care diagnostic devices carry great promises for global health, including meeting urgent needs for testing and diagnosis in places with limited laboratory facilities. Unfortunately, the production and disposal of single-use devices, whether in lateral flow assay, cartridges, cassettes, or lab-on-chip microfluidic format, also poses significant challenges for environmental
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High-throughput Probing Macrophage-bacteria Interactions at the Single Cell Level with Microdroplets Lab Chip (IF 6.799) Pub Date : 2022-06-23 Zhongyun Jiang, Sidi Liu, Xiang Xiao, Guimei Jiang, Qing Qu, Xinxing Miao, Renfei Wu, Rui Shi, Ruochen Guo, Jian Liu
Pathogenic infections may lead to disruption of homeostasis, thus becoming a serious threat to the human health. Understanding the interactions between bacteria and macrophages is critical for the therapeutic development against sepsis or inflammatory bowel disease. Here, we report the technique of droplet biosensors for the detection of nitric oxide (NO) secreted by a single macrophage under inflammatory
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Centrifugal disc liquid reciprocation flow considerations for antibody binding to COVID antigen array during microfluidic integration Lab Chip (IF 6.799) Pub Date : 2022-06-21 Alexander T. Hwu, Masoud Madadelahi, Rie Nakajima, Ehsan Shamloo, Alexandra Perebikovsky, Horacio Kido, Aarti Jain, Algis Jasinskas, Shawna Prange, Philip Felgner, Marc Madou
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Single-Cell Chemical Proteomics (SCCP) Interrogates the Timing and Heterogeneity of Cancer Cell Commitment to Death Anal. Chem. (IF 6.986) Pub Date : 2022-06-22 Ákos Végvári, Jimmy E. Rodriguez, Roman A. Zubarev
Chemical proteomics studies the effects of drugs upon a cellular proteome. Due to the complexity and diversity of tumors, the response of cancer cells to drugs is also heterogeneous, and thus, proteome analysis at the single-cell level is needed. Here, we demonstrate that single-cell proteomics techniques have become quantitative enough to tackle the drug effects on target proteins, enabling single-cell
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Multicolor Polystyrene Nanosensors for the Monitoring of Acidic, Neutral, and Basic pH Values and Cellular Uptake Studies Anal. Chem. (IF 6.986) Pub Date : 2022-06-22 Priyanka Srivastava, Isabella Tavernaro, Claudia Genger, Pia Welker, Oskar Hübner, Ute Resch-Genger
A first tricolor fluorescent pH nanosensor is presented, which was rationally designed from biocompatible carboxylated polystyrene nanoparticles and two analyte-responsive molecular fluorophores. Its fabrication involved particle staining with a blue-red-emissive dyad, consisting of a rhodamine moiety responsive to acidic pH values and a pH-inert quinoline fluorophore, followed by the covalent attachment
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Thermogravimetric Analysis on a Resonant Microcantilever Anal. Chem. (IF 6.986) Pub Date : 2022-06-22 Fanglan Yao, Pengcheng Xu, Hao Jia, Xinyu Li, Haitao Yu, Xinxin Li
Thermogravimetric analysis (TGA) is a widely applied classic method for material characterization. However, the existing TGA method has reached its technical ceiling in regard to its sensitivity, efficiency, application scope, and extensibility. With temperature-programming and a picogram (10–12 g) mass resoluble measurement function, an integrated resonant microcantilever is proposed and developed
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Reversible and Highly Ordered Biointerfaces for Efficient Capture and Nondestructive Release of Circulating Tumor Cells Anal. Chem. (IF 6.986) Pub Date : 2022-06-22 Siyi Wang, Jiasen Cui, Qian Fan, Jiaxing Gan, Chunran Liu, Yuanhe Wang, Ting Yang, Jianhua Wang, Chaoyong Yang
The engineering strategy of artificial biointerfaces is vital for governing their performances in bioanalysis and diagnosis. Highly ordered arrangement of affinity ligands on the interface surface facilitates efficient interaction with target molecules, whereas biointerfaces aimed at drug delivery or rare cell isolation require sophisticated stimuli-response mechanisms. However, it is still challenging
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Fast and specific enrichment and quantification of cancer-related exosomes by DNA-nanoweight-assisted centrifugation Anal. Chem. (IF 6.986) Pub Date : 2022-06-22 Zhangwei Lu, Ye Shi, Yuxuan Ma, Bin Jia, Xintong Li, Xiaoxiang Guan, Zhe Li
Exosomes are nanoscale membrane vesicles actively released by cells and play an important role in the diagnosis of cancer-related diseases. However, it is challenging to efficiently enrich exosomes from extracellular fluids. In this work, we used DNA nanostructures as “nanoweights” during centrifugation to facilitate the enrichment of cancerous exosomes in human serum. Two different DNA tetrahedral
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Fully Inkjet-Printed Chemiresistive Sensor Array Based on Molecularly Imprinted Sol–Gel Active Materials ACS Sens. (IF 7.711) Pub Date : 2022-06-22 Xiao Ye, Lingpu Ge, Tianshu Jiang, Hao Guo, Bin Chen, Chuanjun Liu, Kenshi Hayashi
The fabrication of chemiresistive sensors by inkjet printing is recognized as a breakthrough in gas-sensing applications. One challenge of this technology, however, is how to enhance the cross-selectivity of the sensor array. Herein, we present a ketjen black (KB) ink and molecularly imprinted sol–gel (MISG) inks to support the fabrication of a fully inkjet-printed chemiresistive sensor array, enabling
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Liquid Precursor-Assisted Chemical Vapor Deposition of One-Dimensional van der Waals Material Nb2Se9: Tunable Growth for Room-Temperature Gas Sensors ACS Sens. (IF 7.711) Pub Date : 2022-06-22 Sang Hoon Lee, Bom Lee, Bum Jun Kim, Byung Joo Jeong, Sooheon Cho, Han Eol Jang, Hyeon Ho Cho, Jae-Hyun Lee, Jae-Hyuk Park, Hak Ki Yu, Jae-Young Choi
In this study, Nb2Se9, a one-dimensional (1D) material with van der Waals (vdWs) bonding, was synthesized by chemical vapor deposition (CVD). A liquid precursor was used to overcome the difficulty of controlling the length and density of Nb2Se9 by CVD due to the high melting point of Nb. Growth proceeded horizontally in a nano-ribbon shape on the substrate in the [100] direction, which had the most
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SERS nanotags for Folate Receptor α detection at the single cell level: discrimination of overexpressing cells and potential for live cell applications Analyst (IF 4.616) Pub Date : 2022-06-22 Alexandre Verdin, Sian Sloan-Dennison, Cedric Malherbe, Duncan Graham, Gauthier Eppe
Folate Receptor α (FRα) is a high affinity folate membrane receptor that is overexpressed in a wide variety of cancers. Detecting the overexpression of this receptor is important for cancer cells identification and to potentially guide the choice of treatment since several FRα-targeted drugs are currently in clinical trials. In this work, we built SERS nanotags based on core@shell Au@Ag nanoparticles