P-glycoprotein (P-gp) inhibition conduces to improving the ability of chemicals to cross through blood-brain barrier (BBB). The hook-bearing branch of Uncaria is used as a traditional herbal medicine for the treatment of hypertension, headache, stroke, and Alzheimer’s disease in recent years. In this study, the inhibitory effects of 8 alkaloids sourced from Uncaria plants on P-gp were evaluated. Meanwhile

Due to the unique nature of localized surface plasmon resonance (LSPR), LSPR has attracted extensive attention in the field of biochemical sensing. However, compared with other sensors, the LSPR biosensor has lower sensitivity which has the limitation of insufficient repeatability and greatly limits its application and further promotion. Many researchers have invested a lot of energy in various ways

In Fourier‐transform ion cyclotron resonance mass spectrometry, ions are detected by measuring image current induced in the detecting electrodes by trapped ions rotating in a magnetic field at their cyclotron frequencies. The ion trap used for this purpose is called the Penning trap. It can have various configurations of electrodes that are used to create a trapping electric field, to excite cyclotron

The importance of thyroid hormones in the regulation of development, growth, and energy metabolism is well known. Over the last decades, mass spectrometry has been extensively used to investigate thyroid hormone metabolism and to discover and characterize new molecules involved in thyroid hormones production, such as thyrotropin‐releasing hormone. In the earlier period, the quantification methods,

Determining metabolomic differences among samples of different phenotypes is a critical component of metabolomics research. With the rapid advances in analytical tools such as ultrahigh‐resolution chromatography and mass spectrometry, an increasing number of metabolites can now be profiled with high quantification accuracy. The increased detectability and accuracy raise the level of stringiness required

It is with great sadness that we learned that Professor Jean‐Claude Dousse passed away on June 21st, 2020. Professor Dousse was the former vice‐dean of the Faculty of Sciences and head of the Atomic and X‐Ray Physics Group at the University of Fribourg, Switzerland. He was also a former member of the editorial board of the X‐Ray Spectrometry journal. Jean‐Claude's contributions to science and the scientific

Dental composite is the most used aesthetic restorative biomaterial worldwide. However, it undergoes polymerization shrinkage that could lead to loss of the interfacial seal between tooth and resin in some circumstances. This demands high‐resolution imaging technologies to detect these defects. This study carried out a comparison between microcomputed tomography (micro‐CT; Shimadzu, Japan) and swept‐source

Glycosaminoglycans (GAG) as long, unbranched polysaccharides are major components of the extracellular matrix (ECM). Many studies provided additional evidence of a specific binding between mediators and sulfated GAG, at which the sulfation code – which means the number and positions of sulfate groups along the polysaccharide chain – plays an important role.

The original article was published in 2008 along with Supporting Information. An archival error resulted in the loss of the link to the Supporting Information file. This Addition and Correction contains the Supporting Information file as it was originally published online on February 22, 2008. The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acs.analchem.0c04818