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Bioinspired Total Syntheses of Grayanotoxins II/III, Kalmanol, and Rhodomollacetals A–C with Three Distinct Skeletons CCS Chem. (IF 11.2) Pub Date : 2024-03-15 Hao Cheng, Tianhao Ma, Xiao Liu, Yanxing Jia
Grayanane diterpenoids, which have intricate molecular architecture and interesting pharmacological properties, have attracted considerable interest of organic chemists since 1970s. However, the total syntheses of grayanane diterpenoids have been accomplished by only seven groups, which have mainly focused on the same carbon skeleton. Herein, we disclose the bioinspired total syntheses of six grayanane
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Imidazole-Linked Fully Conjugated Covalent Organic Framework for High-Performance Sodium-Ion Battery CCS Chem. (IF 11.2) Pub Date : 2024-03-15 Lu Liu, Yu Gong, Yifan Tong, Hao Tian, Xubo Wang, Yiming Hu, Shaofeng Huang, Weiwei Huang, Sandeep Sharma, Jingnan Cui, Yinghua Jin, Weitao Gong, Wei Zhang
Covalent organic frameworks (COFs) have garnered increasing attention as promising electrode materials for sodium-ion batteries (SIBs) due to their ordered backbones, uniform pore sizes, and high surface areas. However, they also face challenges, including low capacity, unsatisfactory rate performance, and limited cycling stability, which pose the primary obstacles to their practical use. Herein, a
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Rhodium-Catalyzed Asymmetric Trifluoromethoxylation of Racemic Allylic Trichloroacetimidates CCS Chem. (IF 11.2) Pub Date : 2024-03-11 Liyan Wang, Yafeng Si, Yu-Xin Luan, Pingping Tang
A rhodium/diene catalyzed asymmetric allylic trifluoromethoxylation reaction is reported, which afforded chiral trifluoromethoxylated allylic compounds in 52–97% yields with up to 97% enantiomeric excess. These are the first examples of asymmetric allylic trifluoromethoxylation. The reactions proceed via a dynamic kinetic process that allowed for the use of racemic allylic trichloroacetimidates as
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Metal–Organic Frameworks Housing Active Molecules as Bioinspired Catalysts CCS Chem. (IF 11.2) Pub Date : 2024-03-12 Yin Zhang, Peter E. VanNatta, Junyu Ren, Shengqian Ma
Optimization of activity, selectivity, and stability of catalysts for practical application is a long-sought-after goal. Recent progress in the advancement of rational catalyst design routinely takes queues from nature. Specifically, enzymes are renowned for their high efficiency and selectivity in diverse and significant reactions under mild conditions. Despite the well-known merits of enzymes, they
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Integrating Homogeneous and Heterogeneous Catalysis in a Copper Nanocluster with Lewis Acid–Base Sites for Chemical Conversion of CO2 and Propargylamine CCS Chem. (IF 11.2) Pub Date : 2024-03-09 Wan-Zhen Qiao, Yu-Jue Wang, Si Li, Rui Wang, Jie Wu, Shuang-Quan Zang
It remains a significant challenge to develop a catalyst that merges the advantages of homogeneous and heterogeneous catalysis with high reactivity and great recyclability. Herein, an atomically precise Cu6-NH2 nanocluster with distorted octahedral Cu6 core and NH2-functionalized ligands has been developed as the first homo/heterogeneous catalyst to catalyze the cyclization reaction of propargylic
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Acceptor-Type Singlet Fission Material Based on Strong Absorption Tetracyanothienoquinoid Skeleton CCS Chem. (IF 11.2) Pub Date : 2024-03-09 Senhao Wang, Xiang-Yang Liu, Mengfan Zhang, Long Wang, Ganglong Cui, Hongbing Fu, Jiannian Yao
The practical efficiency of singlet fission (SF)-based photovoltaic devices is still far from satisfactory due to the limited scope of SF materials suitable for device application and the scarcity of schemes available for triplet utilization. Most SF materials identified to date are typically electron donors while acceptor-type SF materials remain largely unexplored. Basically, the combination of a
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Radiation-Assisted Synthesis of Crown Ether-Modified Covalent Organic Frameworks for Lithium Isotope Separation CCS Chem. (IF 11.2) Pub Date : 2024-03-08
CCS Chemistry, Ahead of Print.
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Tumor Imaging by a 99mTcO4−-Labeled Cationic Polymeric Network CCS Chem. (IF 11.2) Pub Date : 2024-03-08 Jie Li, Rongzhen Xie, Baoyu Li, Lixi Chen, Wenhao Shen, Yuting Zhao, Qi Guo, Long Chen, Boqi Xu, Xijian Chen, Jingwen Guan, Lei Chen, Kai Yang, Zhifang Chai, Shuao Wang
Technetium-99m (99mTc) is the most used (>80%) radionuclide in the clinical nuclear diagnostic imaging procedure. The traditional approach to preparing 99mTc-based imaging agents utilizes stannous chloride (SnCl2) for the reduction of noncomplexing pertechnetate (99mTcO4−) to low-valent Tc [e.g., Tc(IV)]. This process, however, is difficult to control precisely and usually results in toxic SnCl2 residue
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A New Nonfullerene Acceptor with Suppressed Energy Disorder for High-Efficiency Organic Solar Cells CCS Chem. (IF 11.2) Pub Date : 2024-03-08 Zi Li, Huifeng Yao, Zhihao Chen, Wenxuan Wang, Yang Xiao, Jianqiu Wang, Junzhen Ren, Tao Zhang, Jiayao Li, Jianhui Hou
Energy disorder is an important factor that affects charge transport, recombination, and energy loss in organic solar cells. Here, we designed a ladder-type nonfullerene acceptor and studied the critical role of energy disorder in photovoltaic performance. Taking a typical seven-member fused ring acceptor IT-4F as an example, we replaced its sp3-hybridized bridging carbon atoms and linked bulky groups
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Facile Blinking Dyes with Spontaneous Enol-Keto Tautomerism for Super-Resolution Imaging of Subcellular Targets CCS Chem. (IF 11.2) Pub Date : 2024-03-08
CCS Chemistry, Ahead of Print.
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Tumor Receptor-Seeking Dyes for Rapid Intraoperative Definition of Tumor Margin and Histopathological Morphology CCS Chem. (IF 11.2) Pub Date : 2024-03-08
CCS Chemistry, Ahead of Print.
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Pd/Zn Dual Catalysis for Site-, Enantio-, and Diastereo-Divergent 2-(Alkoxycarbonyl)allylation of α-Hydroxyketones with Morita–Baylis–Hillman Adducts CCS Chem. (IF 11.2) Pub Date : 2024-03-08 Yong Liu, Chaopeng Li, Rui Zhang, Zibo Liu, Zhaobin Han, Zheng Wang, Kuiling Ding
A synergistic Pd/Zn dual chiral catalyst system has been developed for the stereodivergent transformation of Morita–Baylis–Hillman (MBH) carbonates and unprotected α-hydroxyketones to afford the corresponding allylation products (>50 examples). These products bearing vicinal stereocenters were obtained in high yields with excellent regio-/diastereo-/enantioselectivities. On cyclization in an acidic
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Encapsulated Fe(IV) Molecular Complex for Photoacoustic Imaging CCS Chem. (IF 11.2) Pub Date : 2024-03-05 Ye Xu, Chao Li, Zhong-Yu Yu, Jiamin Wang, Zhaoyang Liu, Chao Jiang, Zhen-Feng Chen, Xiaoyu Wu, Ming-Xing Li, Hong Yang, Zhao-Xi Wang, Jonathan L. Sessler
A stable neutral Fe(IV) complex (Fe-HDCL), readily accessible on the g scale, was found to possess high water solubility and good stability (>5% degradation over 4 h upon photoirradiation). Fe-HDCL is green and absorbs light effectively in the visible region (500–800 nm) with a λmax at 650 nm (ε = 7830 M−1 cm−1). Fe-HDCL also exhibits photothermal (PT) behavior comparable to single-wall carbon nanotubes
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Single-Molecule Characterization of van der Waals Contact Between Alkane and Gold CCS Chem. (IF 11.2) Pub Date : 2024-03-05 Hongyu Ju, Jinying Wang, Wangping Liu, Jie Hao, Mengmeng Li, Yanxia Xu, Boyu Wang, Suhang He, Kunrong Mei, Andrew C.-H. Sue, Keqiu Chen, Chuancheng Jia, Xuefeng Guo
Van der Waals (vdW) contact, dominated by weak but ubiquitous vdW interactions, plays a significant role in diverse fields such as supramolecular chemistry, nanotechnology, and surface science. Accurate characterization of vdW contact at the single-molecule level remains challenging. Herein, we combine the scanning tunneling microscope break junction technique with first-principles calculations to
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A Bioorthogonal Post-modification of N6-Isopentenyl Adenosine i6A RNA in Live Cells CCS Chem. (IF 11.2) Pub Date : 2024-02-29 Li-Jun Xie, Hou-Ping Cheng, Meng-Yuan Chen, Xin Wang, Li Liu, Bi-Feng Yuan, Liang Cheng
Selective methods for modulating RNA epigenetic modifications within living cells and organisms represent attractive techniques for investigating biological functions and medicinal application. In contrast to enzymatic methods, abiotic chemical modulation offers access to diverse new-to-natural functionalities. We herein report a visible light-assisted bioorthogonal reaction involving flavin mononucleotide
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Photoexcitation of Dihydroquinazolinone Anionic Compounds: Difluoroalkylarylation and Difluoroalkylamination of Alkenes CCS Chem. (IF 11.2) Pub Date : 2024-02-29 Jian-Xiong Yang, Jia-Qing Hu, Qi Wen, Jie Xu, Yan Zhang, Heng Jiang
The direct excitation of dihydroquinazolinone (DHQ) anions by visible light has been demonstrated by photophysical experiments. The excited-state DHQ anion serves as both a potent reductant and a radical precursor in a redox neutral radical cascade, circumventing the use of an external photoredox catalyst. Various gem-difluoroalkyl radicals (CF2H and CF2R) are produced from the excited-state DHQ anions
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Kinetic Resolution of Racemic 4-Substituted Chroman-2-ones Through Asymmetric Lactone Hydrogenation CCS Chem. (IF 11.2) Pub Date : 2024-02-29
CCS Chemistry, Ahead of Print.
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Author Spotlight CCS Chem. (IF 11.2) Pub Date : 2024-03-01
CCS Chemistry, Volume 6, Issue 3, Page 532-536, March 2024.
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Spontaneous Symmetry Breaking of Iridium and Ruthenium Metallophosphors for the Constructions of Chiral Light-Harvesting Systems CCS Chem. (IF 11.2) Pub Date : 2024-02-29
CCS Chemistry, Ahead of Print.
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Hierarchical Homochiral Assembly of Polyhedral Cage-Type Nanoclusters CCS Chem. (IF 11.2) Pub Date : 2024-02-28 Cheng-Long Deng, Bao-Liang Han, Ze-Yu Liu, Zhong-Hua Pan, Jiao He, Yu-Long Li, Zhi-Lin Yang, Geng-Geng Luo, Chen-Ho Tung, Di Sun, Lan-Sun Zheng
Hierarchical chiral self-assembly is of profound significance for biomolecules for their biological functions. Atom-precise metal nanoclusters (NCs) offer better opportunities to construct hierarchical superlattices. Nevertheless, achieving hierarchical homochiral assembly of nanocrystals protected by achiral ligands has proven to be a formidable task, with existing examples primarily limited to heterochiral
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Research Progress in Enantioselective Radical Desymmetrization Reactions CCS Chem. (IF 11.2) Pub Date : 2024-02-24 Chang-Jiang Yang, Lin Liu, Qiang-Shuai Gu, Xin-Yuan Liu
Enantioselective radical desymmetrization is a highly effective approach for rapidly creating enantioenriched molecules, introducing dramatically increased structural complexity from readily available prochiral or meso compound feedstocks. Two strategic modes have been developed for these reactions, which differ in the nature of the stereo-determining steps. The first category deals primarily with
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Selective Alkane Desaturation Catalyzed by Molecular Cage Copper Complexes Under Mild Conditions CCS Chem. (IF 11.2) Pub Date : 2024-02-23
CCS Chemistry, Ahead of Print.
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Inherently Chiral and Symmetrical Heteroatom-Doped Zigzag-Type Hydrocarbon Belts CCS Chem. (IF 11.2) Pub Date : 2024-02-23 Xue-Yuan Wang, Xin-Yu Zhang, Shuo Tong, Qing-Hui Guo, Mei-Ling Tan, Cheng-Jun Li, Mei-Xiang Wang
Recent years have witnessed a resurgence of study in hydrocarbon belts due to their potential applications in carbon nanotechnology. By contrast, heteroatom-embedded zigzag hydrocarbon belts as advanced design strategies with fascinating structures and desirable, unique properties have remained largely unexplored, and inherently chiral ones are unknown. Herein, we report the synthesis of a diversity
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Construction of Planar Chiral Ferrocenes by Cobalt-Catalyzed Enantioselective C-H Acyloxylation Enabled by Dual Ligand CCS Chem. (IF 11.2) Pub Date : 2024-02-24 Fan-Rui Huang, Peng Zhang, Qi-Jun Yao, Bing-Feng Shi
Oxy-substituted planar chiral ferrocenes are of great importance in asymmetric synthesis and pharmaceutical. However, enantioselective C-H activation of ferrocenes to form C-O bonds remains a huge challenge and has not been reported yet. Herein, the asymmetric synthesis of oxy-substituted planar chiral ferrocenes is achieved by cobalt-catalyzed enantioselective dehydrogenative C-H acyloxylation. The
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Metal-Free, Site-Selective C–H Fluorination of Heteroarenes Under Visible Light CCS Chem. (IF 11.2) Pub Date : 2024-02-21
CCS Chemistry, Ahead of Print.
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Discovery and Asymmetric Total Synthesis of Phlegmine A as a Selective Inhibitor of ASIC1a CCS Chem. (IF 11.2) Pub Date : 2024-02-22 Zai-Feng Yuan, Fei Liu, Yu-Fei Ou, Wen-Yan Li, Li-Yan Peng, Xiao-Nian Li, Qin-Shi Zhao
Phlegmine A ( 1), a novel type of Lycopodium alkaloid with a unique skeleton, was isolated from the rare and endangered herbal medicinal plant, Phlegmariurus phlegmaria. Spectroscopic methods and X-ray diffraction analysis were employed to unambiguously elucidate the structure of phlegmine A ( 1). Furthermore, we realized the asymmetric total synthesis of the natural product phlegmine A ( 1) in 18
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Stereodivergent Benzylic Substitution of Racemic Secondary Benzyl Esters Enabled by Pd/Cu Dual Catalysis CCS Chem. (IF 11.2) Pub Date : 2024-02-22 Youbin Peng, Guanlin Li, Chongyu Han, Yicong Luo, Xiaohong Huo, Wanbin Zhang
Transition-metal-catalyzed asymmetric benzylic substitution of racemic benzyl esters is an efficient and straightforward route towards the construction of benzylic stereocenters but remains a challenge, due to the difficulty encountered in the suppression of β–H elimination and asymmetric induction. Herein, we successfully developed a highly diastereo- and enantioselective benzylic substitution of
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A Machine Learning Model for Predicting Enantioselectivity in Hypervalent Iodine(III) Catalyzed Asymmetric Phenolic Dearomatizations CCS Chem. (IF 11.2) Pub Date : 2024-02-22
CCS Chemistry, Ahead of Print.
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Heterogeneous Catalysis with Metal-Containing Crystalline Porous Materials: Element- and Site-Specific Insights CCS Chem. (IF 11.2) Pub Date : 2024-02-20 Yan Li, Andrew G. Walsh, Peng Zhang, Tianjun Zhang
Metal-containing crystalline porous materials (CPMs) are gaining popularity in heterogeneous catalysis because of their highly crystalline and porous systems, and their excellent chemical tunability. Modification of the metal species and framework structure permits them to have greater activity, selectivity, and stability over other materials. An in-depth understanding of the complex nature of metal
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Recent Advances in Cobalt-Catalyzed Regio- or Stereoselective Hydrofunctionalization of Alkenes and Alkynes CCS Chem. (IF 11.2) Pub Date : 2024-02-20
CCS Chemistry, Ahead of Print.
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Cobalt Single Atom-Catalyzed Formation of LiOH in Li-O2 Batteries via the Direct 4-Electron Oxygen Reduction Pathway CCS Chem. (IF 11.2) Pub Date : 2024-02-21 Kang Huang, Hao Wan, Zhichao Gong, Jianbin Liu, Minmin Yan, Jun Wu, Chunyu Cui, Gonglan Ye, Karsten Reuter, Huilong Fei
The formation of LiOH as the discharge product instead of Li2O2 in Li-O2 batteries (LOBs) is highly desirable due to the associated drawbacks of Li2O2-based chemistry, which involves the generation of reactive oxygen intermediates responsible for substantial side reactions. However, the current challenge lies in the formation pathway of LiOH, which typically requires the chemical hydrolysis of the
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Sequence Engineering in Tuning the Circularly Polarized Luminescence of Aggregation-Induced Emission-Active Hetero[3]rotaxanes CCS Chem. (IF 11.2) Pub Date : 2024-02-21 Zhiyong Peng, Pei-Pei Jia, Xu-Qing Wang, Xiao-Li Zhao, Hai-Bo Yang, Wei Wang
Based on a [2]rotaxane precursor with exchangeable pentafluorophenyl ester stoppers, a new wheel-assembling approach has been successfully developed for the precise sequence control of hetero[3]rotaxanes, leading to the facile and efficient synthesis of both sequence isomers of hetero[3]rotaxanes. More importantly, taking advantage of the chirality retention along with the wheel-assembling process
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Robust Giant Octahedral [6+8] Porous Organic Cages for Efficient Ethylene/Ethane Separation CCS Chem. (IF 11.2) Pub Date : 2024-02-20 Lijuan Feng, Yan-Xi Tan, El-Sayed M. El-Sayed, Fenglei Qiu, Wenjing Wang, Kongzhao Su, Daqiang Yuan
The exploration of ethane (C2H6)-selective porous materials for the direct production of polymer-grade ethylene (C2H4) from a C2H6/C2H4 mixture in a single energy-saving adsorption step is of utmost importance but remains a significant challenge. Thus, developing robust C2H6-selective adsorbents with high C2H6 capacity and C2H6/C2H4 selectivity is urgently needed for industrial applications. In this
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Hole-Selective Contact with Molecularly Tailorable Reactivity for Passivating High-Performing Inverted Perovskite Solar Cells CCS Chem. (IF 11.2) Pub Date : 2024-02-20
CCS Chemistry, Ahead of Print.
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Flexible Organic Crystal with Two-Dimensional Elastic Bending and Recoverable Plastic Twisting for Circularly Polarized Luminescence CCS Chem. (IF 11.2) Pub Date : 2024-02-20
CCS Chemistry, Ahead of Print.
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Bipolar Thermally Activated Delayed Fluorescence Emitter with Balanced Carrier Transport for High-Efficiency Nondoped Green Electroluminescent Devices CCS Chem. (IF 11.2) Pub Date : 2024-02-20
CCS Chemistry, Ahead of Print.
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Phosphine-Built-In Porous Organic Cage Supported Ultrafine Pd Nanoclusters Enable Highly Efficient and Regioselective Hydrogenation of Epoxides CCS Chem. (IF 11.2) Pub Date : 2024-02-20 Xin Zhou, Zhaozhan Wang, Zhe-Ning Chen, Yong Yang
Selective hydrogenation of epoxides has been regarded as an atom-economical and straightforward method for the synthesis of alcohols. However, it remains a big challenge in the precise control of regioselectivity. To date, the reaction enabled by a reusable and high-performance heterogeneous catalyst with excellent regioselectivity is very scarce. Herein, we develop highly loaded and ultrafine Pd nanoclusters
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Hierarchical Self-Assembly Promoted Circularly Polarized Luminescence Enhancement and Handedness Inversion of Metal–Organic Helicate CCS Chem. (IF 11.2) Pub Date : 2024-02-20
CCS Chemistry, Ahead of Print.
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Intense Intramolecular Charge Transfer Endows Cyanated Polymer with Broad Absorption, Intensified Light-Harvesting, Long-Lived Exciton, and Superior Photovoltaic Property CCS Chem. (IF 11.2) Pub Date : 2024-02-20 Jinming Chen, Huijuan Wang, Songmin Mo, Hui Chen, Xinyu He, Mingbin Su, Dongyan Li, Yonghong Xiao, Zhiqi Wang, Fanwei Ye, Mingde Li, Li Dang, Xiao-Chun Huang, Chang-Zhi Li, Feng He, Qinghe Wu
The donor–acceptor (D–A) copolymers, which exhibit wide broad absorption and intensified light-harvesting, are highly captivating for applications in solar conversion and optoelectronics. However, designing a polymer structure that can achieve these photophysical properties simultaneously remains a challenge. Herein, we report two novel cyanated units 4-cyanobenzo[1,2-b:6,5-b′:3,4-c″]trithiophene (CBT)
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7-Oxa-2,3-Diazanorbornene: A One-Step Accessible Monomer for Living Ring-Opening Metathesis Polymerization to Produce Backbone-Biodegradable Polymers CCS Chem. (IF 11.2) Pub Date : 2024-02-20 Xiaoyang Wang, Yixing Wen, Yu Wang, Wei Li, Xueguang Lu, Wei You
Traditional ring-opening metathesis polymerization (ROMP) reactions exhibit broad functional group compatibility and precise control over polymer architectures, albeit with non-biodegradable backbones. Recent progress has resulted in a series of biodegradable ROMP products with diverse cleavable functional groups, yet the majority of the monomers display moderate to low ring strain, which restricts
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Photoinduced Radical-Ionic Transfer of Various Chlorofluorocarbons to Alkenes from Oxime-Based Surrogates CCS Chem. (IF 11.2) Pub Date : 2024-02-20 Jinghui Zhang, Muliang Zhang, Martin Oestreich
Functional-group-transfer strategies that avoid the use of unsustainable chemicals are attractive for the development of green methodologies. Chlorofluorocarbons (CFCs) not only contribute to the depletion of the stratospheric ozone layer, but their gaseous nature also poses a serious threat in scientific laboratories. Hence, the design of effective and sustainable alternatives to CFCs is highly desirable
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ZnO HoMS@ZIF-8 Nanoreactors for Efficient Enrichment and Photoreduction of Atmospheric CO2 CCS Chem. (IF 11.2) Pub Date : 2024-02-20 Yanze Wei, Juan Li, Decai Zhao, Yasong Zhao, Qinghua Zhang, Lin Gu, Jiawei Wan, Dan Wang
The ultimate goal of photocatalytic CO2 reduction is to efficiently convert atmospheric CO2 into value-added products by designing hierarchical photocatalysts that combine effective harvesting and accelerate activation capabilities of CO2 molecules. In this work, we demonstrated direct air-level CO2 reduction by hollow multishell structure (HoMS) nanoreactors with zeolitic imidazolate framework-8 (ZIF-8)-modified
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Eco-Friendly Encapsulation of Metal Clusters in Porous Organic Cages for Engineerable Microenvironment and Enhanced Catalysis CCS Chem. (IF 11.2) Pub Date : 2024-02-05
CCS Chemistry, Ahead of Print.
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Three-Component Transformation of CO2, Propargyl Alcohols and Secondary Amines into β-Oxopropylcarbamates Promoted by a Noble Metal-Free Metal–Organic Framework Catalyst CCS Chem. (IF 11.2) Pub Date : 2024-02-05
CCS Chemistry, Ahead of Print.
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Author Spotlight CCS Chem. (IF 11.2) Pub Date : 2024-02-03
CCS Chemistry, Volume 6, Issue 2, Page 271-275, February 2024.
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Recyclable Perovskite Solar Cells with Lead Sulfate Contact CCS Chem. (IF 11.2) Pub Date : 2024-02-01 Guo-Bin Xiao, Xijiao Mu, Luyao Wang, Zhen-Yang Suo, Artem Musiienko, Guixiang Li, Zeying Guo, Yiying Wu, Antonio Abate, Jing Cao
Previous cost analysis of perovskite solar cells (PSCs) has revealed that the transparent conductive oxide (TCO) substrates account for most of the material cost, emphasizing the need to recover TCO in PSC recycling. However, the conventional use of compact and ultrathin electron transport materials (ETMs) such as TiO2 and SnO2, poses a challenge to their removal from the substrate, hindering effective
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Atomic Manganese Manipulating Polysulfide Speciation Pathway for Room-Temperature Na-S Batteries CCS Chem. (IF 11.2) Pub Date : 2024-02-01 Hong Zhang, Mingli Wang, Xiang-Long Huang, Songtao Lu, Ke Lu, Xiaohong Wu
Sluggish polysulfide redox kinetics, especially the high energy barrier of rate-determining short-chain polysulfide conversion and the high activation barrier of Na2S decomposition during sulfur recovery, compromise the full potential of rechargeable Na-S electrochemistry. Herein we construct the hierarchical sandwich-structured carbon matrix with atomically dispersed Mn-N4 Lewis acidic sites, taking
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Inflammation-Targeting Fullerene Nanoparticles Dually Inhibit Macrophage and Osteoclast Differentiation for Mitigating Rheumatoid Arthritis CCS Chem. (IF 11.2) Pub Date : 2024-02-01
CCS Chemistry, Ahead of Print.
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Converting Azine Linkage into Highly Stable (Thio)Urea-Based Bicyclic-Fused-Ring Connections in Covalent Organic Frameworks via Criss-Cross [3+2] Cycloaddition CCS Chem. (IF 11.2) Pub Date : 2024-02-01 Zhi-Bei Zhou, Hui-Hui Sun, Qiao-Yan Qi, Xin Zhao
Exploring new linkage chemistry is of fundamental significance for covalent organic frameworks (COFs) to expand their structure and functional diversity. Herein, we report a strategy for converting azine linkage into urea- and thiourea-based fused-ring connections in COFs by criss-cross [3+2] dipolar cycloaddition of azine with HNCO or KSCN. The as-prepared COFs with cyclized linkages exhibited enhanced
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Zinc Ion-Induced Immune Responses in Antitumor Immunotherapy CCS Chem. (IF 11.2) Pub Date : 2024-01-27 Ying Yang, Huanhuan Fan, Xinyu Xu, Shankun Yao, Wenhao Yu, Zijian Guo
Zinc has emerged as a crucial metal in the field of antitumor immunotherapy. Despite its recognized significance, the specific molecular mechanisms behind zinc ion-mediated antitumor immune responses remain inadequately elucidated. Herein, we present a comprehensive analysis of the effects of zinc ions on immune regulation in antitumor immunotherapy. Zinc ions overload within tumor cells results in
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Atomically Dispersed Pt and NiO Clusters Synergistically Enhanced C–O Bond Hydrogenolysis CCS Chem. (IF 11.2) Pub Date : 2024-01-27 Junjuan Yang, Sen Luan, Minghua Dong, Yuxuan Wu, Xueqing Xing, Xingwu Liu, Junfeng Xiang, Zhijuan Zhao, Shaopeng Li, Bin Zhang, Huizhen Liu, Buxing Han
C–O bond activation is a highly efficient, fundamental strategy in the depolymerization and hydrodeoxygenation of chemicals with oxygen-containing functional groups such as oil, coal, and biomass. Developing efficient catalysts for C–O activation with ultralow-loading noble and non-noble metals is highly desirable for the improvement of metal atomic utilization. Herein, bimetallic catalysts with atomically
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Orientation Bias of Self-Assembled Alkanes and Their Derivatives Under Dynamic Lateral Nanoconfinement Conditions CCS Chem. (IF 11.2) Pub Date : 2024-01-27 Lihua Yu, Yuanzhi Xia, Tianze Hu, Brent Daelemans, Steven De Feyter
Self-assembled molecular networks (SAMNs) formed on crystalline solid substrates result from the spontaneous arrangement of individual molecules into structured patterns. The interaction between molecules and the substrate leads to a nonrandom orientation of SAMNs with respect to the substrate’s lattice. In the case of graphite, the sixfold rotational symmetry of the substrate results in an equivalent
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Seeing Is Believing: Directly Imaging Contractions of Artificial Molecular Muscles with Platinum Atom Markers CCS Chem. (IF 11.2) Pub Date : 2024-01-27 Dan-Yang Zhang, Yonghui Zheng, Yefei Jiang, Wei-Jian Li, Xu-Qing Wang, Lianrui Hu, Wei Wang, Hai-Bo Yang
Artificial molecular muscles undergo well-controlled contractile and extensile motions upon external stimulation, leading to remarkable length changes. Evaluating such length changes at the molecular level is essential to the design of integrated artificial molecular muscles that mimic biological muscles. Taking advantage of the strong contrast of platinum (Pt) atoms in high-angle annular dark-field
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Engineering Cell-Selective Charge-Altering Lipid Nanoparticles for Efficient siRNA Delivery in Vivo CCS Chem. (IF 11.2) Pub Date : 2024-01-25 Fengrui Yang, Lingling Lei, Xiangnan Wang, Jieling Hong, Zhenkun Wu, Jian-Hui Jiang
Lipid nanoparticles (LNPs) have emerged as a powerful platform for RNA delivery; the chemical engineering of LNP for efficient delivery of RNA into cytosol remains critical but challenging. One promising strategy is the use of permanently positively charged lipids, which have been shown to enhance the stability and delivery efficiency of LNPs. However, the resulting strong electrostatic interactions
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Ferricyanide-Promoted Oxidative Activation and Ligation of Protein Thioacids in Neutral Aqueous Media CCS Chem. (IF 11.2) Pub Date : 2024-01-25 Guo-Chao Chu, Lu-Jun Liang, Rui Zhao, Yan-Yan Guo, Chun-Tong Li, Chong Zuo, Huasong Ai, Xiao Hua, Zi-Chen Li, Yi-Ming Li, Lei Liu
Ferricyanide-promoted oxidative activation of N-acylated α-aminothioacids for amide bond formation with α-aminonitriles was recently shown to be a plausible pathway for prebiotic peptide synthesis. Herein we describe the finding that by adding sodium azide and thiols, ferricyanide oxidation can elicit highly efficient and clean conversion of fully unprotected peptide or protein thioacids in neutral
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Effect of Free Radicals on Irradiation Chemistry of a Double-Coordination Organotin (Sn4) Photoresist by Adjusting Alkyl Ligands CCS Chem. (IF 11.2) Pub Date : 2024-01-24 Hao Chen, Yifeng Peng, Haichao Fu, Fuping Han, Guangyue Shi, Feng Luo, Jun Zhao, Danhong Zhou, Pengzhong Chen, Xiaojun Peng
Metal oxide cluster (MOC) photoresists are highly promising materials for the next generation of extreme ultraviolet lithography (EUVL). The consecutive exploration of novel MOC materials and their structural irradiation chemistry are the major concerns associated with EUVL. Herein, we report two bicoordinated tin-oxo clusters (TOCs), the organic ligands of which contain both adamantane carboxylic
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Divergent Synthesis of Primary Amides via Modular Dearomative Carbamoylations of Arene π-Systems CCS Chem. (IF 11.2) Pub Date : 2024-01-24 Chu-Qiao Li, Xu Jiang, Ming-Yang Wang, Wei-Long Zeng, Wei Li
In sharp contrast to the well researched and well developed aminocarbonylation of alkenes, the dearomative carbamoylation of abundant arene π-systems has scarcely been studied despite its great potential to enrich the diversity-oriented synthesis of high-value amides. The formidable challenges associated with such dearomatization include the low reactivity of stable aromatic π-systems and intricate
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Effect of Free Radicals on Irradiation Chemistry of a Double-Coordination Organotin (Sn4) Photoresist by Adjusting Alkyl Ligands CCS Chem. (IF 11.2) Pub Date : 2024-01-24 Hao Chen, Yifeng Peng, Haichao Fu, Fuping Han, Guangyue Shi, Feng Luo, Jun Zhao, Danhong Zhou, Pengzhong Chen, Xiaojun Peng
Metal oxide cluster (MOC) photoresists are highly promising materials for the next generation of extreme ultraviolet lithography (EUVL). The consecutive exploration of novel MOC materials and their structural irradiation chemistry are the major concerns associated with EUVL. Herein, we report two bicoordinated tin-oxo clusters (TOCs), the organic ligands of which contain both adamantane carboxylic