Ferroptosis, a recently identified form of non-apoptotic programmed cell death, has attracted significant attention in the field of cancer therapy due to its unique mechanism of cell death. To meet the demands of ferroptosis-mediated cancer treatment, several small molecule-based drugs have been reported for the implementation of ferroptosis. However, some cancer cells are inherently resistant to these

Difluoromethyl ethers are formed through mechanochemical reactions of alcohols with difluorocarbene in a mixer mill. The protocol could be applied to primary, secondary, and tertiary alcohols, yielding the corresponding products in excellent yields (up to 99%) after 1 h reaction time at room temperature. The transformations proceeded under solvent-free reaction conditions, followed by product purification

Flexible-robust hydrogen-bonded organic frameworks (HOFs) are attracting increasing interest due to their excellent separation performance for important industrial gases, but the construction remains challenging. Herein, a sticked-layer strategy is first proposed to construct a flexible-robust HOF, HOF-FJU-8, from a donor (D)–π–acceptor (A) molecule 4,4′,4″,4‴-(pyrrolo[3,2-b]pyrrole-1,2,4,5-tetrayl)tetrabenzonitrile

CCS Chemistry, Volume 5, Issue 6, Page 1251-1254, May 2023.

CCS Chemistry, Volume 5, Issue 6, Page 1255-1258, May 2023.

An array of natural products bearing chiral peroxide motifs display antitumor, anticancer, and antiparasitic activities. However, there are very few catalytic asymmetric syntheses of chiral peroxides. Moreover, effective catalysts for asymmetric catalytic peroxidations are limited to chiral amines. To further expand synthetic access to chiral peroxides, the development of new catalysts realizing catalytic

Light-induced recognition, assemblies, and materials are intensive areas of research due to their high spatiotemporal resolution. Herein, we demonstrated photoswitchable molecular recognition via dithienylethene-triggered reversible structural regulation of dynamic covalent hydrazone bonds. By combining dithienylethenes and cyclic hemiacetals, the photochemical open-ring and closed-ring forms enabled

Biomolecular self-assembly based on peptides and proteins is a general phenomenon encountered in natural and synthetic systems. Liquid–liquid phase separation (LLPS) is intimately involved in biomolecular self-assembly, yet the key factors at a molecular scale activating or modulating such a process remain largely elusive. Herein, we discovered in our experiments that multistep desolvation is fundamental

A general method for the synthesis of bench-stable bis(difluoromethyl) pentacoordinate phosphoranes has been developed. The reaction is rapid, operationally simple, and easily scalable. The pentacoordinate phosphoranes can generate both difluoromethyl radical (·CF2H) and difluorocarbene (:CF2) intermediates. Thus, a variety of fluoroalkylation transformations have been achieved by ·CF2H, such as oxidative

The deuterodifluoromethyl group CF2D combines the structural features of CF3 and CD3 groups, finding wide applications in diverse pharmaceutical entities. In this work, the electrochemical mono-deuterodefluorination of Ar-CF3 to Ar-CF2D is achieved with an unreported deuterium atom transfer-coupled electron transfer pathway using D2O as the only D source for the first time. A series of Ar-CF3 substances

Asymmetric dearomatization reactions of various electron-deficient heteroarenes, including benzofurans, benzothiophenes, and indoles, have been described. Through a phosphine-catalyzed [3+2] annulation with vinylcyclopropanes, readily available heteroarene feedstocks undergo smooth dearomatization reactions, delivering a diverse array of valuable chiral cyclopentabenzodihydrofuran and cyclopentaindoline

Organic photovoltaic (OPV) cells have demonstrated remarkable performance in small, spin-coated areas. Nevertheless significant challenges persist in the form of large efficiency losses due to the fact that the ideal morphology cannot be preserved in the transition of small-area cells to large-scale panels. Herein, the ternary strategy of incorporating the third component FTCC-Br into the active layer

Targeted protein degradation (TPD) is an emerging tool for degrading proteins of interest, which affords an attractive modality for cancer therapy. However, the present TPD technologies must engage a proteolysis-specific actuator to initiate degradation of targeted proteins in the proteasome or lysosome. Herein, we report an artificial tractor that can induce endocytosis-mediated protein depletion

Cyclic dinucleotides (CDNs) are natural agonists of the stimulator of interferon genes (STING), which is an attractive immunotherapy target. Currently, CDNs and their derivatives are being investigated clinically. However, the poor bioavailability of exogenous CDNs has limited their application in immunotherapy. Although nanocarriers are widely used for cytosolic delivery of CDNs, their loading capacity

Interface engineering in device fabrication is a significant but complicated issue. Although great successes have been achieved by conventional physical in situ or ex situ methods, it still suffers from complicated procedures. In this work, we present a facile method for fabricating phthalocyanine (Pc)-based two-dimensional conductive metal–organic framework (MOF) films. Based on PcM-Cu (M = Ni, Cu

The high-yield synthesis of ultrastable porous organic cages (POCs) by facile methods is highly desirable but challenging. Inspired by highly stable sp2 carbon-conjugated (C=C) covalent organic frameworks, we used rational design and synthesized the first family of sp2 carbon-linked POCs (sp2c-POCs) with triangular prism shapes by a one-step Knoevenagel reaction that is a high yield [2+3] condensation

The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has claimed millions of lives and caused innumerable economic losses worldwide. Unfortunately, state-of-the-art treatments still lag behind the continual emergence of new variants. Key to resolving this issue is developing antivirals to deactivate coronaviruses regardless of their

Herein, we report three novel electron-deficient aromatics, ethenylene-bridged bisisoindigos 3,3′-((3E,3′E)-((E)-ethene-1,2-diyl)bis(1-(4-decyltetradecyl)-2-oxoind-oline-6-yl-3-ylidene))bis(1-(4-decyltetradecyl)-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one) ( NCCN), 3,3′-((3E,3′E)-((E)-ethene-1,2-diyl)bis(1-(4-decyltetradecyl)-7-fluoro-2-oxoindoline-6-yl-3-ylidene))bis(1-(4-decyltetradecyl)-1,3-dihydro-2H-pyrrolo[2

Organic electrode materials have attracted much attention for lithium batteries because of their high capacity, flexible designability, and environmental friendliness. Understanding the redox chemistry of organic electrode materials is essential for optimizing electrochemical performance and designing new molecules. This review aims to summarize the redox chemistry of different organic electrode materials

Amide is essential in biologically active compounds, synthetic materials, and building blocks. However, conventional amide production relies on energy-intensive consumption and activating agents that modulate processes to construct the C–N bond. Herein, for the first time, we have successfully realized the formation of amides at industrial current density via the anodic coelectrolysis of alcohol and

The expansion of protein topological diversity requires new and efficient synthetic tools. Herein, we report the second and third generations of the SpyStapler-mediated SpyTag/BDTag ligation system for the efficient synthesis of 4-arm star proteins and the repurposing of the third generation as an active template to enable the synthesis of higher-order protein [n]catenanes (n = 3, 4, and 5). SpyStapler003

The sensitivity and fidelity of surface electromyography (sEMG) signal monitoring is critical for muscle status and fatigue assessment, prosthetic control, and gesture recognition. However, the incompatible skin-electrode interface and complex electrophysiological environment restrict the sensitive acquisition and accurate analysis of sEMG signals. Focused on the impedance of the skin-electrode interface

Molecular profiling of cell-surface proteins is a powerful strategy for precise cancer diagnosis. While mass cytometry (MC) enables synchronous detection of over 40 cellular parameters, its full potential in disease classification is challenged by the limited types of recognition probes currently available. In this work, we synthesize a panel of heavy isotope-conjugated aptamers to profile cancer-associated

As open substructures of fullerenes, aromatic π-bowls are promising candidates as new organic semiconductors, as well as attractive hosts for fullerenes. We demonstrate herein the synthesis and characterization of a novel C2v symmetric π-bowl, pyracyleno[6,5,4,3,2,1-pqrstuv]pentaphene ( 3). Bowl 3 was equipped with two distinctive reactive sites, allowing for bromination and cross-coupling reactions

Owing to the shortcomings of traditional electrode materials in alkali metal-ion batteries (AIBs), such as limited reversible specific capacity, low power density, and poor cycling performance, it is particularly important to develop new electrode materials. Covalent organic frameworks (COFs) are crystalline porous polymers that incorporate organic building blocks into their periodic structures through

A distinct class of C1-symmetric N-heterocyclic carbene (NHC) ligands possessing a chiral fused tetrahydroquinoline ring and a chiral N-arylmethyl group was designed and synthesized via an asymmetric catalytic synthesis strategy. Their copper(I) complexes were successfully applied to asymmetric borylation/cyclization tandem reactions, providing facile access to a broad range of chiral borylated 2,3-trans-3

Nonconjugated clusteroluminogens (CLgens), such as proteins and polystyrene, have become increasingly important in photophysics. They show many advantages over traditional conjugated dyes with fused aromatic rings in biological applications. However, CLgens have historically been unheeded because of their weak visible emissions in the aggregate state, namely clusteroluminescence (CL). Changing the

CCS Chemistry, Volume 5, Issue 5, Page 1018-1022, May 2023.

CCS Chemistry, Volume 5, Issue 5, Page 1023-1027, May 2023.

Rapid halide anion exchange easily occurring in metal-halide perovskite nanoparticles (NPs) makes it nearly impossible to create a single three-dimensional (3D) CsPbX3 (X = Cl, Br, I) NP that simultaneously comprises two separate perovskite components. To circumvent this problem, we first propose a Ni2+-mediated halide anion-exchange strategy in zero-dimensional (0D) Ni2+-doped Cs4PbBr6 (Cs4PbBr6:Ni)

Organic moieties-derived salts with permanent porosity and polarized channels have shown unique features and attractive performance in the field of adsorption, separation, and conduction. However, state-of-the-art organic salts generally rely on ionic interaction and hydrogen bonding formation to maintain the porous channels. The synthesis of organic moiety-derived salts with permanent accessible pores

It has been well-documented that the charging of Li-ion battery (LIB) is accompanied by volume expansion, a significant source of their capacity fading and structural failure. However, existing operando techniques for measuring battery expansion either use single-point detection to report the local deformation or are not sensitive enough for hard-pack cylindrical batteries. Here, we propose an optical

The direct cleavage of C–NO2 bonds for reductive denitration of nitroarenes remains a challenging transformation in synthetic organic chemistry. Herein, we report a biocompatible palladium-deposited graphdiyne nanocatalyst (Pd@GDY/DSPE-PEG) that can catalyze reductive denitration of nitroarenes under ambient physiological conditions. Mechanistic studies support this transformation via the oxidative

Achieving a straightforward design of tough, printable, and adaptable polymeric eutectogels is still challenging in related fields due to the uncontrollable polymerization and solvent-exchanging processes, and inherent contrasting multiple networks. Here, we report a one-step synergistic strategy based on ruthenium chemistry-catalyzed photopolymerization and solvent effect for preparing high-performance

The incorporation of heteroatoms into carbon nanohoops can significantly overcome aromatic stabilization energy and enrich their physicochemical properties depending on the positions and numbers of the doped atoms. Utilizing a V-shaped dipyreneo[c,e]dihydrophenazine as the building block, herein we report a novel kind of axially N-embedded quasi-carbon nanohoops by integrating π-extended dihydropyrazine

Metal sulfides are emerging highly active electrocatalysts for the oxygen evolution reaction (OER), but still suffer from the instability caused by their inevitable reconstruction, especially at industrial-level current density. Here, it is discovered that Fe-incorporated Ni3S2 nanowires can deliver extraordinary durability with an ultralow potential degradation rate of 0.006 mV/h in alkaline electrolytes

We have developed a rotaxane-based mechanophore system that is capable of breaking a mechanical bond and releasing small molecules via force-triggered rotaxane disassembly. In this design, a cyclobutane mechanophore was fused to the ring component of a rotaxane, constructed through a template-mediated synthesis in high yields. Upon opening the ring component, the rotaxane disassembled to release the

Electrochemical water splitting plays a crucial role in storing sustainable energy into H2 as an ideal fuel, in which the anodic oxygen evolution reaction (OER) is the bottleneck. Currently, Fe-doped NiOOH (Ni1−xFexOOH) is a promising OER catalyst under alkaline conditions. However, the specific active sites responsible for their good performances remain debatable. Here, we identify a nickel-oxygen

Suitable conformations and proper alignment of complex natural macrocycles are essential for achieving their unique properties. However, such artificial macrocycle prototypes are still limited due to synthetic difficulties. In this respect, directly linked porphyrin analog dimers display tunable conformations and intriguing properties, and thus, they may be employed as a class of promising platforms

CCS Chemistry, Volume 5, Issue 4, Page 772-775, March 2023.

CCS Chemistry, Volume 5, Issue 4, Page 776-780, March 2023.

The capture, storage, and release of CO2 is one of the most pressing issues in chemistry. Herein, we designed bis(formazanate) magnesium complexes as precursors, which were synthesized by straightforward transamination between the neutral formazan [PhNNC(4-tBuPh)NNHPh] (LH) and [Mg{N(SiMe3)2}2]. Depending on the solvent, either the homoleptic complex [L2Mg] or the thf-coordinated complex [L2Mg(thf)]

Simultaneous ethane and acetylene removal from a C2-gases mixture (C2H6, C2H4, and C2H2) through a one-step separation process for ethylene purification is of great importance yet challenging in petrochemical industry, owing to their similar molecule sizes and physical properties. Herein, a series of multi-functionalized metal–organic frameworks (MOFs), LIFM-XYY-1∼8 (LIFM stands for Lehn Institute

The sluggish lithium-ion (Li-ion) transport kinetics in graphite anode hinders its application in fast-charging Li-ion batteries (LIBs). Here, we develop an ion-pumping interphase (IPI) on graphdiyne (GDY)/graphite heterojunction anodes to boost the ionic transport kinetics and enable high-performance, fast-charging LIBs. The IPI changed the ion solvation/desolvation environment by covalent/non-covalent

Sub-nanowires (SNWs), ∼1 nm in thickness, possess an inorganic skeleton but display characteristics akin to those of carbon–carbon backbone polymers, such as flexibility, adhesion, gelation, self-assembling behaviors, and shear-thinning properties. Despite this, the underlying mechanism for these polymer-like properties remains unexplored. This study investigates the origin of SNWs’ unique behavior

Photodynamic therapy (PDT) has emerged as an efficient method for cancer therapy. However, traditional photosensitizers (PSs) always have low bioavailability. For example, hydrophobic PSs tend to aggregate in cells and lead to aggregation-induced quenching; while hydrophilic PSs that have good solubility in water systems can hardly penetrate into cells whose membranes are lipophilic. To overcome these

The power conversion efficiency (PCE) of polymer solar cells (PSCs) has recently increased quickly, propelling PSCs closer to large-scale commercialization. However, several critical issues, such as the cost of materials and the sensitivity of the PCE to active-layer thickness, must be addressed before industrial application can be realized on a large scale. Here, we fabricated a high-performance ternary

Epoxides are important chemicals and used in multiple fields. The conventional thermal-catalytic production of epoxides consumes a large amount of energy and generates abundant carbon emissions. Therefore, sustainable manufacturing technologies are highly desired. Taking advantage of renewable electricity to drive electrochemical epoxidation reactions provides a novel approach to generating value-added

Innovative design of sensing fluorophores possessing superior photophysical properties, porosity, and packing-resistance structures is pivotal for high performance film-based fluorescent sensors. Herein, PDCB, a perylene monoimide (PMI) derivative incorporating large spatial phenyl-carborane was synthesized and found to exhibit unexpected photophysical properties. The structurally bent PDCB exhibits

CCS Chemistry, Volume 5, Issue 3, Page 524-527, February 2023.

CCS Chemistry, Volume 5, Issue 3, Page 528-530, February 2023.

CCS Chemistry, Ahead of Print.

CCS Chemistry, Ahead of Print.

CCS Chemistry, Ahead of Print.

CCS Chemistry, Ahead of Print.

CCS Chemistry, Ahead of Print.

CCS Chemistry, Ahead of Print.

CCS Chemistry, Ahead of Print.

CCS Chemistry, Ahead of Print.

CCS Chemistry, Ahead of Print.