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Photo-Activated Ferroptosis for Cancer Therapy: Advances, Challenges, and Prospects CCS Chem. Pub Date : 2023-06-02 Le Yu, Yunjie Xu, Jong Seung Kim
Ferroptosis, a recently identified form of non-apoptotic programmed cell death, has attracted significant attention in the field of cancer therapy due to its unique mechanism of cell death. To meet the demands of ferroptosis-mediated cancer treatment, several small molecule-based drugs have been reported for the implementation of ferroptosis. However, some cancer cells are inherently resistant to these
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Mechanochemical Difluoromethylations of Alcohols CCS Chem. Pub Date : 2023-06-02 Pit van Bonn, Jinbo Ke, Christopher Weike, Jas S. Ward, Kari Rissanen, Carsten Bolm
Difluoromethyl ethers are formed through mechanochemical reactions of alcohols with difluorocarbene in a mixer mill. The protocol could be applied to primary, secondary, and tertiary alcohols, yielding the corresponding products in excellent yields (up to 99%) after 1 h reaction time at room temperature. The transformations proceeded under solvent-free reaction conditions, followed by product purification
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Sticked-Layer Strategy to a Flexible-Robust Hydrogen-Bonded Organic Framework for Efficient C2H2/CO2 Separation CCS Chem. Pub Date : 2023-06-02 Zhen Yuan, Xianghua Jiang, Liangji Chen, Junjie Chen, Lu Li, Yisi Yang, Yunbin Li, Fahui Xiang, Shengchang Xiang, Banglin Chen, Zhangjing Zhang
Flexible-robust hydrogen-bonded organic frameworks (HOFs) are attracting increasing interest due to their excellent separation performance for important industrial gases, but the construction remains challenging. Herein, a sticked-layer strategy is first proposed to construct a flexible-robust HOF, HOF-FJU-8, from a donor (D)–π–acceptor (A) molecule 4,4′,4″,4‴-(pyrrolo[3,2-b]pyrrole-1,2,4,5-tetrayl)tetrabenzonitrile
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Author Spotlight CCS Chem. Pub Date : 2023-05-30
CCS Chemistry, Volume 5, Issue 6, Page 1255-1258, May 2023.
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Chiral Betaine-Mediated Asymmetric Peroxidation-Kinetic Resolution Cascade for the Synthesis of Optically Pure Peroxides CCS Chem. Pub Date : 2023-05-24 Xiangyuan Liu, Kang Du, Jisheng Luo, Li Deng
An array of natural products bearing chiral peroxide motifs display antitumor, anticancer, and antiparasitic activities. However, there are very few catalytic asymmetric syntheses of chiral peroxides. Moreover, effective catalysts for asymmetric catalytic peroxidations are limited to chiral amines. To further expand synthetic access to chiral peroxides, the development of new catalysts realizing catalytic
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Photoswitchable Molecular Recognition Enabled by Dithienylethene-Mediated Structural Changes of Dynamic Covalent Hydrazone Bonds CCS Chem. Pub Date : 2023-05-24 Lifeng Wang, Hanxun Zou, Hebo Ye, Yu Hai, Hanwei Lu, Junmiao Deng, Lei You
Light-induced recognition, assemblies, and materials are intensive areas of research due to their high spatiotemporal resolution. Herein, we demonstrated photoswitchable molecular recognition via dithienylethene-triggered reversible structural regulation of dynamic covalent hydrazone bonds. By combining dithienylethenes and cyclic hemiacetals, the photochemical open-ring and closed-ring forms enabled
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Multistep Desolvation as a Fundamental Principle Governing Peptide Self-Assembly Through Liquid–Liquid Phase Separation CCS Chem. Pub Date : 2023-05-24 Chengqian Yuan, Ruirui Xing, Jie Cui, Wei Fan, Junbai Li, Xuehai Yan
Biomolecular self-assembly based on peptides and proteins is a general phenomenon encountered in natural and synthetic systems. Liquid–liquid phase separation (LLPS) is intimately involved in biomolecular self-assembly, yet the key factors at a molecular scale activating or modulating such a process remain largely elusive. Herein, we discovered in our experiments that multistep desolvation is fundamental
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Pentacoordinate Phosphoranes as Versatile Reagents in Fluoroalkylation Reactions CCS Chem. Pub Date : 2023-05-24 Huanhuan Song, Weihao Li, Xiaoying Wang, Kaiteng Wang, Jingwen Li, Shuai Liu, Pin Gao, Xin-Hua Duan, Jinbo Hu, Mingyou Hu
A general method for the synthesis of bench-stable bis(difluoromethyl) pentacoordinate phosphoranes has been developed. The reaction is rapid, operationally simple, and easily scalable. The pentacoordinate phosphoranes can generate both difluoromethyl radical (·CF2H) and difluorocarbene (:CF2) intermediates. Thus, a variety of fluoroalkylation transformations have been achieved by ·CF2H, such as oxidative
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Electrochemical Mono-Deuterodefluorination of Trifluoromethyl Aromatic Compounds with Deuterium Oxide CCS Chem. Pub Date : 2023-05-22 Jie Sheng, Xu Cheng
The deuterodifluoromethyl group CF2D combines the structural features of CF3 and CD3 groups, finding wide applications in diverse pharmaceutical entities. In this work, the electrochemical mono-deuterodefluorination of Ar-CF3 to Ar-CF2D is achieved with an unreported deuterium atom transfer-coupled electron transfer pathway using D2O as the only D source for the first time. A series of Ar-CF3 substances
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Asymmetric Dearomatization of Electron-Deficient Heteroarenes by a Phosphine-Catalyzed [3+2] Annulation with Vinylcyclopropanes CCS Chem. Pub Date : 2023-05-16 Xuan Dai, Fuhao Zhang, Lei Dai, Yixin Lu
Asymmetric dearomatization reactions of various electron-deficient heteroarenes, including benzofurans, benzothiophenes, and indoles, have been described. Through a phosphine-catalyzed [3+2] annulation with vinylcyclopropanes, readily available heteroarene feedstocks undergo smooth dearomatization reactions, delivering a diverse array of valuable chiral cyclopentabenzodihydrofuran and cyclopentaindoline
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Manipulating Film Formation Kinetics Enables Organic Photovoltaic Cells with 19.5% Efficiency CCS Chem. Pub Date : 2023-05-16 Jianqiu Wang, Pengqing Bi, Yafei Wang, Zhong Zheng, Zhihao Chen, Jiawei Qiao, Wenxuan Wang, Jiayao Li, Cunbin An, Shaoqing Zhang, Xiaotao Hao, Jianhui Hou
Organic photovoltaic (OPV) cells have demonstrated remarkable performance in small, spin-coated areas. Nevertheless significant challenges persist in the form of large efficiency losses due to the fact that the ideal morphology cannot be preserved in the transition of small-area cells to large-scale panels. Herein, the ternary strategy of incorporating the third component FTCC-Br into the active layer
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Artificial Nucleic Acid Tractor-Directed Simultaneous Depletion of Oncogenic Membrane Proteins Without Hijacking Proteolysis-Specific Actuator CCS Chem. Pub Date : 2023-05-16 Zhen Zou, Songlan Pan, Qian Xue, Ting Chen, Ziyun Huang, Bei Qing, Pengfei Liu, Conghui Zhao, Yunlin Sun, Erhu Xiong, Ronghua Yang
Targeted protein degradation (TPD) is an emerging tool for degrading proteins of interest, which affords an attractive modality for cancer therapy. However, the present TPD technologies must engage a proteolysis-specific actuator to initiate degradation of targeted proteins in the proteasome or lysosome. Herein, we report an artificial tractor that can induce endocytosis-mediated protein depletion
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Cyclic Dinucleotide Self-Assembled Nanoparticles as a Carrier-Free Delivery Platform for STING-Mediated Cancer Immunotherapy CCS Chem. Pub Date : 2023-05-13 Lang Zhao, Shao-Hua Zhuo, Tian-Yang Wang, Jun-Jun Wu, Jing-Yun Su, Wen-Hao Li, Bo-Dou Zhang, Yan-Mei Li
Cyclic dinucleotides (CDNs) are natural agonists of the stimulator of interferon genes (STING), which is an attractive immunotherapy target. Currently, CDNs and their derivatives are being investigated clinically. However, the poor bioavailability of exogenous CDNs has limited their application in immunotherapy. Although nanocarriers are widely used for cytosolic delivery of CDNs, their loading capacity
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Two-Dimensional Conductive Metal–Organic Framework Reinforced Spinterface in Organic Spin Valves CCS Chem. Pub Date : 2023-05-13 Xiaoyu Song, Chao Jin, Hongliang Chen, Shuaishuai Ding, Zhongyi Liu, Yang Li, Xiaoli Yan, Wenbo Mi, Long Chen, Wenping Hu
Interface engineering in device fabrication is a significant but complicated issue. Although great successes have been achieved by conventional physical in situ or ex situ methods, it still suffers from complicated procedures. In this work, we present a facile method for fabricating phthalocyanine (Pc)-based two-dimensional conductive metal–organic framework (MOF) films. Based on PcM-Cu (M = Ni, Cu
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Highly Stable sp2 Carbon-Conjugated Porous Organic Cages CCS Chem. Pub Date : 2023-05-12 Fenglei Qiu, Xun Chen, Wenjing Wang, Kongzhao Su, Daqiang Yuan
The high-yield synthesis of ultrastable porous organic cages (POCs) by facile methods is highly desirable but challenging. Inspired by highly stable sp2 carbon-conjugated (C=C) covalent organic frameworks, we used rational design and synthesized the first family of sp2 carbon-linked POCs (sp2c-POCs) with triangular prism shapes by a one-step Knoevenagel reaction that is a high yield [2+3] condensation
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Extracellular Disintegration of Viral Proteins as an Innovative Strategy for Developing Broad-Spectrum Antivirals Against Coronavirus CCS Chem. Pub Date : 2023-05-12 Ke Sun, Zhe Ding, Xiaoying Jia, Haonan Cheng, Yingwen Li, Yan Wu, Zhuoyu Li, Xiaohua Huang, Fangxu Pu, Entao Li, Guiyou Wang, Wei Wang, Yun Ding, Gary Wong, Sandra Chiu, Jiaming Lan, Aiguo Hu
The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has claimed millions of lives and caused innumerable economic losses worldwide. Unfortunately, state-of-the-art treatments still lag behind the continual emergence of new variants. Key to resolving this issue is developing antivirals to deactivate coronaviruses regardless of their
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Heteroatom Structural Engineering Enables Ethenylene-Bridged Bisisoindigo-Based Copolymers to Exhibit Unique n-Type Transistor Performance CCS Chem. Pub Date : 2023-05-09 Yuchai Pan, Weifeng Zhang, Yankai Zhou, Xuyang Wei, Hao Luo, Jinbei Wei, Liping Wang, Gui Yu
Herein, we report three novel electron-deficient aromatics, ethenylene-bridged bisisoindigos 3,3′-((3E,3′E)-((E)-ethene-1,2-diyl)bis(1-(4-decyltetradecyl)-2-oxoind-oline-6-yl-3-ylidene))bis(1-(4-decyltetradecyl)-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one) ( NCCN), 3,3′-((3E,3′E)-((E)-ethene-1,2-diyl)bis(1-(4-decyltetradecyl)-7-fluoro-2-oxoindoline-6-yl-3-ylidene))bis(1-(4-decyltetradecyl)-1,3-dihydro-2H-pyrrolo[2
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Perspectives on the Redox Chemistry of Organic Electrode Materials in Lithium Batteries CCS Chem. Pub Date : 2023-05-05 Yong Lu, Qiu Zhang, Jun Chen
Organic electrode materials have attracted much attention for lithium batteries because of their high capacity, flexible designability, and environmental friendliness. Understanding the redox chemistry of organic electrode materials is essential for optimizing electrochemical performance and designing new molecules. This review aims to summarize the redox chemistry of different organic electrode materials
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Anodic Electrosynthesis of Amide from Alcohol and Ammonia CCS Chem. Pub Date : 2023-05-05 Yuxuan Lu, Yingying Li, Bo Zhou, Jingcheng Wu, Ling Zhou, Yuping Pan, Zhongcheng Xia, Ming Yang, Yandong Wu, Zhenran Yuan, Rixin Peng, Zhijie Kong, Shuangyin Wang, Yuqin Zou
Amide is essential in biologically active compounds, synthetic materials, and building blocks. However, conventional amide production relies on energy-intensive consumption and activating agents that modulate processes to construct the C–N bond. Herein, for the first time, we have successfully realized the formation of amides at industrial current density via the anodic coelectrolysis of alcohol and
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Active Template Synthesis of Protein [n]Catenanes Using Engineered Peptide–Peptide Ligation Tools CCS Chem. Pub Date : 2023-05-05 Fan Zhang, Yajie Liu, Yu Shao, Wen-Bin Zhang
The expansion of protein topological diversity requires new and efficient synthetic tools. Herein, we report the second and third generations of the SpyStapler-mediated SpyTag/BDTag ligation system for the efficient synthesis of 4-arm star proteins and the repurposing of the third generation as an active template to enable the synthesis of higher-order protein [n]catenanes (n = 3, 4, and 5). SpyStapler003
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An Interfacial Gel Electrode Patch with Tunable Hydrogen Bond Network for Electromyographic Sensing and Discrimination CCS Chem. Pub Date : 2023-05-05 Jianliang Li, Zhihao Liu, Yongtao Tang, Jiabao Xian, Chaofan He, Hao Wu, Mingjie Liu, Fengyu Li
The sensitivity and fidelity of surface electromyography (sEMG) signal monitoring is critical for muscle status and fatigue assessment, prosthetic control, and gesture recognition. However, the incompatible skin-electrode interface and complex electrophysiological environment restrict the sensitive acquisition and accurate analysis of sEMG signals. Focused on the impedance of the skin-electrode interface
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Aptamer-Based Cell-Surface Profiling with Single-Cell Resolution Enables Precise Cancer Characterization CCS Chem. Pub Date : 2023-05-05 Liujun Xu, Yawei Feng, Tong Wang, Shenhuan Li, Kangli Xu, Yue Sun, Yi Luo, Yishan Ye, Yan Miao, Yun Dong, Zhenzhen Guo, Qing Zhang, Benshang Li, He Huang, Xue-Qiang Wang, Liping Qiu, Weihong Tan
Molecular profiling of cell-surface proteins is a powerful strategy for precise cancer diagnosis. While mass cytometry (MC) enables synchronous detection of over 40 cellular parameters, its full potential in disease classification is challenged by the limited types of recognition probes currently available. In this work, we synthesize a panel of heavy isotope-conjugated aptamers to profile cancer-associated
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Excellent π-Bowl Semiconductors Based on C70 Subunit CCS Chem. Pub Date : 2023-05-04 Meng Chen, Yuxiao Duan, Xinyue Liu, Qian Zhan, Hironobu Hayashi, Kyohei Matsuo, Hiroko Yamada, Guangpeng Gao, Yonghao Zheng, Lei Zhang
As open substructures of fullerenes, aromatic π-bowls are promising candidates as new organic semiconductors, as well as attractive hosts for fullerenes. We demonstrate herein the synthesis and characterization of a novel C2v symmetric π-bowl, pyracyleno[6,5,4,3,2,1-pqrstuv]pentaphene ( 3). Bowl 3 was equipped with two distinctive reactive sites, allowing for bromination and cross-coupling reactions
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Recent Advances in Covalent Organic Framework Electrode Materials for Alkali Metal-Ion Batteries CCS Chem. Pub Date : 2023-05-02 Jianlu Sun, Yifan Xu, Yanqi Lv, Qichun Zhang, Xiaosi Zhou
Owing to the shortcomings of traditional electrode materials in alkali metal-ion batteries (AIBs), such as limited reversible specific capacity, low power density, and poor cycling performance, it is particularly important to develop new electrode materials. Covalent organic frameworks (COFs) are crystalline porous polymers that incorporate organic building blocks into their periodic structures through
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Tunable Unsymmetrical Chiral N-Heterocyclic Carbene Ligands for Highly Diastereo- and Enantioselective Copper-Catalyzed Tandem Borylative Cyclization: Ligand Controlled Diastereoselectivity Reversal CCS Chem. Pub Date : 2023-05-02 Jiahong Han, Yan-Mei He, Yixiao Pan, Faju Li, Dongyu Li, Wei Hao, Qing-Hua Fan
A distinct class of C1-symmetric N-heterocyclic carbene (NHC) ligands possessing a chiral fused tetrahydroquinoline ring and a chiral N-arylmethyl group was designed and synthesized via an asymmetric catalytic synthesis strategy. Their copper(I) complexes were successfully applied to asymmetric borylation/cyclization tandem reactions, providing facile access to a broad range of chiral borylated 2,3-trans-3
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Controllable Secondary Through-Space Interaction and Clusteroluminescence CCS Chem. Pub Date : 2023-05-02 Zuping Xiong, Jianyu Zhang, Lei Wang, Yuan Xie, Yipu Wang, Zujin Zhao, Haoke Zhang, Jing Zhi Sun, Feihe Huang, Ben Zhong Tang
Nonconjugated clusteroluminogens (CLgens), such as proteins and polystyrene, have become increasingly important in photophysics. They show many advantages over traditional conjugated dyes with fused aromatic rings in biological applications. However, CLgens have historically been unheeded because of their weak visible emissions in the aggregate state, namely clusteroluminescence (CL). Changing the
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Author Spotlight CCS Chem. Pub Date : 2023-05-01
CCS Chemistry, Volume 5, Issue 5, Page 1023-1027, May 2023.
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Achieving Intrinsic Dual-Band Excitonic Luminescence from a Single Three-Dimensional Perovskite Nanoparticle Through Ni2+-Mediated Halide Anion Exchange CCS Chem. Pub Date : 2023-04-28 Licheng Yu, Youchao Wei, Yuanchao Lei, Caiping Liu, Yongsheng Liu, Maochun Hong
Rapid halide anion exchange easily occurring in metal-halide perovskite nanoparticles (NPs) makes it nearly impossible to create a single three-dimensional (3D) CsPbX3 (X = Cl, Br, I) NP that simultaneously comprises two separate perovskite components. To circumvent this problem, we first propose a Ni2+-mediated halide anion-exchange strategy in zero-dimensional (0D) Ni2+-doped Cs4PbBr6 (Cs4PbBr6:Ni)
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Expeditious Coordination-Driven Construction of Hierarchically Nanoporous Barium Salts CCS Chem. Pub Date : 2023-04-28 Xian Suo, Yuqing Fu, Juntian Fan, Chi-Linh Do-Thanh, De-en Jiang, Shannon M. Mahurin, Zhenzhen Yang, Sheng Dai
Organic moieties-derived salts with permanent porosity and polarized channels have shown unique features and attractive performance in the field of adsorption, separation, and conduction. However, state-of-the-art organic salts generally rely on ionic interaction and hydrogen bonding formation to maintain the porous channels. The synthesis of organic moiety-derived salts with permanent accessible pores
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Dynamic Volumography of Cylindrical Li-Ion Battery Cells by Watching Its Breath During Cycling CCS Chem. Pub Date : 2023-04-19 Wenxuan Jiang, Haoran Li, Sicong Wang, Sa Wang, Wei Wang
It has been well-documented that the charging of Li-ion battery (LIB) is accompanied by volume expansion, a significant source of their capacity fading and structural failure. However, existing operando techniques for measuring battery expansion either use single-point detection to report the local deformation or are not sensitive enough for hard-pack cylindrical batteries. Here, we propose an optical
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Denitration of Nitroarenes Under Ambient Physiological Conditions Catalyzed by Graphdiyne-Supported Palladium CCS Chem. Pub Date : 2023-04-19 Endong Zhang, Yanyan Chen, Fengting Lv, Zicheng Zuo, Feng He, Yongjun Li, Yiming Huang, Yuliang Li, Shu Wang
The direct cleavage of C–NO2 bonds for reductive denitration of nitroarenes remains a challenging transformation in synthetic organic chemistry. Herein, we report a biocompatible palladium-deposited graphdiyne nanocatalyst (Pd@GDY/DSPE-PEG) that can catalyze reductive denitration of nitroarenes under ambient physiological conditions. Mechanistic studies support this transformation via the oxidative
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Designing Tough, Printable, and Adaptable Eutectogels with Multinetworks via Synergy of Rapid Orthogonal Photopolymerizations and Solvent Effect in Seconds CCS Chem. Pub Date : 2023-04-17 Jupen Liu, Lijun Zhou, Ping Zhang, Yanxia Zhao, Hongqiu Wei, You Yu
Achieving a straightforward design of tough, printable, and adaptable polymeric eutectogels is still challenging in related fields due to the uncontrollable polymerization and solvent-exchanging processes, and inherent contrasting multiple networks. Here, we report a one-step synergistic strategy based on ruthenium chemistry-catalyzed photopolymerization and solvent effect for preparing high-performance
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Axially N-Embedded Quasi-Carbon Nanohoops with Multioxidation States CCS Chem. Pub Date : 2023-04-11 Shuhai Qiu, Yongye Zhao, Li Zhang, Yong Ni, Yanan Wu, Huan Cong, Da-Hui Qu, Wei Jiang, Jishan Wu, He Tian, Zhaohui Wang
The incorporation of heteroatoms into carbon nanohoops can significantly overcome aromatic stabilization energy and enrich their physicochemical properties depending on the positions and numbers of the doped atoms. Utilizing a V-shaped dipyreneo[c,e]dihydrophenazine as the building block, herein we report a novel kind of axially N-embedded quasi-carbon nanohoops by integrating π-extended dihydropyrazine
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Mitigating the Reconstruction of Metal Sulfides for Ultrastable Oxygen Evolution at High Current Density CCS Chem. Pub Date : 2023-04-11 Shuai Niu, Tang Tang, Yuanju Qu, Yuyun Chen, Hao Luo, Hui Pan, Wen-Jie Jiang, Jianan Zhang, Jin-Song Hu
Metal sulfides are emerging highly active electrocatalysts for the oxygen evolution reaction (OER), but still suffer from the instability caused by their inevitable reconstruction, especially at industrial-level current density. Here, it is discovered that Fe-incorporated Ni3S2 nanowires can deliver extraordinary durability with an ultralow potential degradation rate of 0.006 mV/h in alkaline electrolytes
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Force-Triggered Guest Release from Mechanophore Incorporated Rotaxanes CCS Chem. Pub Date : 2023-04-11 Jinghui Yang, Yan Xia
We have developed a rotaxane-based mechanophore system that is capable of breaking a mechanical bond and releasing small molecules via force-triggered rotaxane disassembly. In this design, a cyclobutane mechanophore was fused to the ring component of a rotaxane, constructed through a template-mediated synthesis in high yields. Upon opening the ring component, the rotaxane disassembled to release the
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Identifying the Active Site of Water Oxidation Catalyst Based on Defective Fe-Doped Ni Oxyhydroxide CCS Chem. Pub Date : 2023-03-30 Yunxuan Ding, Jian Du, Tao Wang, Licheng Sun
Electrochemical water splitting plays a crucial role in storing sustainable energy into H2 as an ideal fuel, in which the anodic oxygen evolution reaction (OER) is the bottleneck. Currently, Fe-doped NiOOH (Ni1−xFexOOH) is a promising OER catalyst under alkaline conditions. However, the specific active sites responsible for their good performances remain debatable. Here, we identify a nickel-oxygen
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Conformation Governed Reactivity of Fused Thia-Sapphyrin Dimers Bearing Multiply Fused Heteroaromatic Rings CCS Chem. Pub Date : 2023-03-30 Qizhao Li, Masatoshi Ishida, Chengjie Li, Glib Baryshnikov, Feng Sha, Bin Zhu, Xinyan Wu, Hans Ågren, Hiroyuki Furuta, Yongshu Xie
Suitable conformations and proper alignment of complex natural macrocycles are essential for achieving their unique properties. However, such artificial macrocycle prototypes are still limited due to synthetic difficulties. In this respect, directly linked porphyrin analog dimers display tunable conformations and intriguing properties, and thus, they may be employed as a class of promising platforms
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Author Spotlight CCS Chem. Pub Date : 2023-03-31
CCS Chemistry, Volume 5, Issue 4, Page 776-780, March 2023.
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Reversible Insertion of CO2 into a Bis(formazanate) Magnesium Complex CCS Chem. Pub Date : 2023-03-24 Da Jin, Xiaofei Sun, Alexander Hinz, Peter W. Roesky
The capture, storage, and release of CO2 is one of the most pressing issues in chemistry. Herein, we designed bis(formazanate) magnesium complexes as precursors, which were synthesized by straightforward transamination between the neutral formazan [PhNNC(4-tBuPh)NNHPh] (LH) and [Mg{N(SiMe3)2}2]. Depending on the solvent, either the homoleptic complex [L2Mg] or the thf-coordinated complex [L2Mg(thf)]
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Dynamic Spacer Installation of Multifunctionalities into Metal–Organic Frameworks for Spontaneous One-Step Ethylene Purification from a Ternary C2-Hydrocarbons Mixture CCS Chem. Pub Date : 2023-03-24 Yang-Yang Xiong, Cheng-Xia Chen, Tony Pham, Zhang-Wen Wei, Katherine A. Forrest, Mei Pan, Cheng-Yong Su
Simultaneous ethane and acetylene removal from a C2-gases mixture (C2H6, C2H4, and C2H2) through a one-step separation process for ethylene purification is of great importance yet challenging in petrochemical industry, owing to their similar molecule sizes and physical properties. Herein, a series of multi-functionalized metal–organic frameworks (MOFs), LIFM-XYY-1∼8 (LIFM stands for Lehn Institute
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An Ion-Pumping Interphase on Graphdiyne/Graphite Heterojunction for Fast-Charging Lithium-Ion Batteries CCS Chem. Pub Date : 2023-03-24 Juan An, Fan Wang, Jia-Yue Yang, Guoxing Li, Yuliang Li
The sluggish lithium-ion (Li-ion) transport kinetics in graphite anode hinders its application in fast-charging Li-ion batteries (LIBs). Here, we develop an ion-pumping interphase (IPI) on graphdiyne (GDY)/graphite heterojunction anodes to boost the ionic transport kinetics and enable high-performance, fast-charging LIBs. The IPI changed the ion solvation/desolvation environment by covalent/non-covalent
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Revealing the Flexibility of Inorganic Sub-Nanowires by Single-Molecule Force Spectroscopy CCS Chem. Pub Date : 2023-03-21 Yuang Shi, Wenxiong Shi, Simin Zhang, Xun Wang
Sub-nanowires (SNWs), ∼1 nm in thickness, possess an inorganic skeleton but display characteristics akin to those of carbon–carbon backbone polymers, such as flexibility, adhesion, gelation, self-assembling behaviors, and shear-thinning properties. Despite this, the underlying mechanism for these polymer-like properties remains unexplored. This study investigates the origin of SNWs’ unique behavior
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Assembled Photosensitizers Applied for Enhanced Photodynamic Therapy CCS Chem. Pub Date : 2023-03-18 Jie Zhao, Xia Xu, Yang Yang, Junbai Li
Photodynamic therapy (PDT) has emerged as an efficient method for cancer therapy. However, traditional photosensitizers (PSs) always have low bioavailability. For example, hydrophobic PSs tend to aggregate in cells and lead to aggregation-induced quenching; while hydrophilic PSs that have good solubility in water systems can hardly penetrate into cells whose membranes are lipophilic. To overcome these
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Low-Cost and High-Performance Polymer Solar Cells with Efficiency Insensitive to Active-Layer Thickness CCS Chem. Pub Date : 2023-03-18 Xiaolei Kong, Jinyuan Zhang, Lei Meng, Chenkai Sun, Xin Jiang, Jianqi Zhang, Can Zhu, Guangpei Sun, Jing Li, Xiaojun Li, Zhixiang Wei, Yongfang Li
The power conversion efficiency (PCE) of polymer solar cells (PSCs) has recently increased quickly, propelling PSCs closer to large-scale commercialization. However, several critical issues, such as the cost of materials and the sensitivity of the PCE to active-layer thickness, must be addressed before industrial application can be realized on a large scale. Here, we fabricated a high-performance ternary
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Advances in Electrochemical Oxidation of Olefins to Epoxides CCS Chem. Pub Date : 2023-03-07 Peng Zhang, Tuo Wang, Jinlong Gong
Epoxides are important chemicals and used in multiple fields. The conventional thermal-catalytic production of epoxides consumes a large amount of energy and generates abundant carbon emissions. Therefore, sustainable manufacturing technologies are highly desired. Taking advantage of renewable electricity to drive electrochemical epoxidation reactions provides a novel approach to generating value-added
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Bi-ortho-Carborane Unit-Riveted Perylene Monoimides: Structure-Tuned Optical Switches for Electron Transfer and Robust Thin Film-Based Fluorescence Sensors CCS Chem. Pub Date : 2023-03-07 Nannan Ding, Yu-Chan Liao, Gang Wang, Kai-Hsin Chang, Zhaolong Wang, Ke Liu, Jiani Ma, Pi-Tai Chou, Yu Fang
Innovative design of sensing fluorophores possessing superior photophysical properties, porosity, and packing-resistance structures is pivotal for high performance film-based fluorescent sensors. Herein, PDCB, a perylene monoimide (PMI) derivative incorporating large spatial phenyl-carborane was synthesized and found to exhibit unexpected photophysical properties. The structurally bent PDCB exhibits
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Author Spotlight CCS Chem. Pub Date : 2023-02-27
CCS Chemistry, Volume 5, Issue 3, Page 528-530, February 2023.
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Sweet Strain Release: Donor–Acceptor Cyclopropane Mediated Glycosylation CCS Chem. Pub Date : 2023-02-25 Xiong Xiao, Han Ding, Li-Cong Peng, Xin-Yu Fang, Yang-Yang Qin, Qiu-Qi Mu & Xue-Wei Liu1School of Chemistry and Chemical Engineering, Northwestern Polytechnical University, Xi’an 7100722School of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, Singapore 637371
CCS Chemistry, Ahead of Print.
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A Novel Nucleobase Modification Strategy for Controlling RNA-Guided Nucleic Acid Cleavage CCS Chem. Pub Date : 2023-02-25 Huajun Lei, Ruochen Fan, Xiaofang Ye, Wei Xiong, Shuangyu Cui, Tianying Zeng, Tian Tian & Xiang ZhouCollege of Chemistry and Molecular Sciences, Key Laboratory of Biomedical Polymers of Ministry of Education, Hubei Province Key Laboratory of Allergy and Immunology, Wuhan University, Wuhan 430072
CCS Chemistry, Ahead of Print.
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Activatable and Self-Monitoring Hydrogen Sulfide-Based Molecular Senomorphics for Visualized Regulation of Cellular Senescence CCS Chem. Pub Date : 2023-02-23 Jili Li, Yuqi Xie, Jian Wang, Linlin Wang, Yinghao Xia, Yanlan Liu & Weihong Tan1Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha, Hunan 4100822The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang
CCS Chemistry, Ahead of Print.
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Genetic Encoding of a Photocaged Glutamate for Optical Control of Protein Functions CCS Chem. Pub Date : 2023-02-17 Xinyu Ling, Yi Zuo, Heqi Chen, Dezhong Ji, Jingjing Wang, Liying Chang, Tao LiuState Key Laboratory of Natural and Biomimetic Drugs, Chemical Biology Center, Department of Molecular and Cellular Pharmacology, Pharmaceutical Sciences, Peking University, Haidian District, Beijing 100191
CCS Chemistry, Ahead of Print.
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High-Mobility Ambipolar Benzodifurandione-Based Copolymers with Regular Donor–Acceptor Dyads Synthesized via Aldol Polycondensation CCS Chem. Pub Date : 2023-02-17 Qian Che, Weifeng Zhang, Xuyang Wei, Yankai Zhou, Hao Luo, Jinbei Wei, Liping Wang & Gui Yu1Beijing National Laboratory for Molecular Sciences, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 1001902School of Chemical Sciences, University of Chinese Academy of Sciences, Beijing 1000493School of Materials Science and Engineering
CCS Chemistry, Ahead of Print.
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Remote Stereocontrol of All-Carbon Quaternary Centers via Cobalt-Catalyzed Asymmetric Olefin Isomerization CCS Chem. Pub Date : 2023-02-17 Xianle Rong, Jie Yang, Shihan Liu, Yu Lan & Qiang Liu1Engineering Research Center of Advanced Rare Earth Materials, Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 1000842Chongqing Key Laboratory of Theoretical and Computational Chemistry, School of Chemistry and Chemical Engineering, Chongqing University, Chongqing 4000303Institute of Green Catalysis, College of Chemistry
CCS Chemistry, Ahead of Print.
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Dynamic Photoresponsive Ultralong Phosphorescence from One-Dimensional Halide Microrods Toward Multilevel Information Storage CCS Chem. Pub Date : 2023-02-17 Chang Xing, Bo Zhou, Dongpeng Yan & Wei-Hai FangKey Laboratory of Theoretical and Computational Photochemistry, Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875
CCS Chemistry, Ahead of Print.
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Selection of Functional Spacer Cations for Efficient 2D/3D Perovskite Solar Cells CCS Chem. Pub Date : 2023-02-16 Dengxue Li, Zhi Xing, Xiangchuan Meng, Xiaotian Hu, Ting Hu & Yiwang Chen1College of Chemistry and Chemical Engineering, Institute of Polymers and Energy Chemistry (IPEC), Nanchang University, Nanchang 3300312National Engineering Research Center for Carbohydrate Synthesis, Key Lab of Fluorine and Silicon for Energy Materials and Chemistry of Ministry of Education, Jiangxi Normal University, Nanchang
CCS Chemistry, Ahead of Print.
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Proximity Chemistry in Living Systems CCS Chem. Pub Date : 2023-02-15 Yanjun Liu, Yun Ge, Ruxin Zeng, William Shu Ching Ngai, Xinyuan Fan & Peng R. Chen1Synthetic and Functional Biomolecules Center, Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 1008712National Key Laboratory of Crop Genetic Improvement
CCS Chemistry, Ahead of Print.