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Front Cover: Divergent Synthesis of 4-Aminotriazoles Through Click Cycloaddition and Generation of Iodonium(III) Triazoles (Eur. J. Org. Chem. 6/2025) Eur. J. Org. Chem. (IF 2.5) Pub Date : 2025-02-10 Takumi Hayashi, Elghareeb E. Elboray, Hina Sudo, Naoko Takenaga, Hiroyuki Satake, Toshifumi Dohi
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Recent Advances in the α-Hydrazination (α-Amination) of Carbonyl Compounds Eur. J. Org. Chem. (IF 2.5) Pub Date : 2025-02-11 Dina Scarpi, Samuele Visi, Ernesto Giovanni Occhiato
The electrophilic α-hydrazination (generally referred to as α-amination) of carbonyl compounds with dialkyl azodicarboxylates is a powerful approach for the preparation of synthetically useful intermediates such as α-amino aldehydes and ketones, α-amino acids, and β-amino alcohols. Many methods for the enantioselective α-hydrazination have been published in the past and many new approaches have been
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Catalytic Reactions of Alkynyl Sulfides: Versatile Tools in Synthetic Chemistry Eur. J. Org. Chem. (IF 2.5) Pub Date : 2025-02-11 Gangguo Zhu, Wenkui Lu, Yao Yuan, Rong Jia
Alkynyl sulfides, a significant class of heteroatom-substituted alkynes, have garnered considerable attention within the synthetic community because of their distinctive characteristics, such as the enhanced reactivity, precise selectivity control, and facile derivatization via C-S bond couplings. Their transformations can provide a direct access to functionalized organosulfur and even sulfur-free
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Recent Advances on Light-Mediated Nitrene Transfer Reactions: An Emerging Area Eur. J. Org. Chem. (IF 2.5) Pub Date : 2025-02-10 Minghan Yao, Gang Chen, Xinke Zhang, Abdulla Yusuf, Xinfang Xu
Nitrogen atoms are fundamental in biological systems and are widely found in approved drugs, natural products, and materials. Thus, catalytic methods for the C-N bond formation have attracted significant attention in synthetic chemistry. Among the toolbox, nitrene transfer reaction is one of the powerful protocols for the construction of N-incorporating frameworks with structural diversity. In this
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Catalytic Asymmetric Azidative Functionalization of Alkenes Eur. J. Org. Chem. (IF 2.5) Pub Date : 2025-02-10 Fuming Zhong, Xiaodan Zhao, Lihao Liao
Aliphatic azides are an important class of nitrogen-containing compounds found in numerous biologically active molecules. Besides, they also serve as useful building blocks owning to their remarkable reactivities. Catalytic azidation of alkenes is an efficient way to produce aliphatic azides. In this respect, azidated chiral molecules can be formed if a chiral catalyst is used. The last quarter of
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Synthesis and Functionalization of Aziridines: A Perspective View from Pharmaceutical Industries Eur. J. Org. Chem. (IF 2.5) Pub Date : 2025-02-10 Jaehee Lee, Xuan Ju, Miseon Lee, Joyce C. Leung
Aziridine is the smallest nitrogen-containing heterocycle. It is not only an important synthetic target but also a useful building block for constructing nitrogen-containing biologically active molecules. Due to the unique properties and reactivity of aziridine, interest in its applications in synthetic organic chemistry and pharmaceutical industry has grown rapidly in recent years. This review highlights
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Water Mediated Chemoselective Synthesis of Novel Spiro benzoxazinoindoline and Extended Synthesis of Spiro benzoxazinoindene Derivatives* Eur. J. Org. Chem. (IF 2.5) Pub Date : 2025-02-10 Diksha Bansal, Pooja Sivaganesan, Chibisree Elanchezhian, Gokulprasanth Nataraj, Mrinal Kanti Das, Saikat Chaudhuri
Spirobenzoxazines are a unique class of heterocyclic compounds that combine the structural features of spiro and benzooxazine frameworks, offering enhanced chemical stability and diverse biological activities. Their rigid three-dimensional structures make them ideal candidates for interacting with biological targets, contributing to their potential in various therapeutic applications, including anticancer
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Acceptor-Donor-Acceptor Systems Based on Indacenodithiophene-Extended Tetrathiafulvalene Eur. J. Org. Chem. (IF 2.5) Pub Date : 2025-02-10 Christina Schøttler, Célia Noël, Laura Le Bras, Hayley Melville, Olivier Alévêque, Arthur H. G. David, Olivier Segut, Maxime Rémond, Eric Levillain, Philippe Blanchard, Mogens Brøndsted Nielsen
Here, we present a series of acceptor-donor-acceptor (A-D-A) conjugated molecules incorporating an indacenodithiophene-extended tetrathiafulvalene (IDT-TTF) as the central electron-donating moiety, functionalized with various lateral electron acceptors. A key synthetic step was the Vilsmeier-Haack formylation of the IDT-TTF, providing the dialdehyde in quantitative yield. This compound was further
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Recent Advances in Zinc‐Catalyzed Carbon‐Heteroatom Bond Formation Eur. J. Org. Chem. (IF 2.5) Pub Date : 2025-02-11 Julio Álvarez-Valle, Patricia García-Martínez, Luis A. López, Javier Santamaría
Zinc has been an overlooked metal in catalysis for many years. However, this situation has begun to change in the last two decades with a number of contributions demonstrating that zinc salts and complexes are able to catalyze transformations typically accomplished with catalysts based on precious transition metals. The development of such zinc‐catalyzed methodologies is highly appealing because, in
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Fluorine-containing 6-Azabicyclo[3.1.1]heptanes: Bicyclic Piperidine Analogs for Drug Discovery Eur. J. Org. Chem. (IF 2.5) Pub Date : 2025-02-07 Anton V. Chernykh, Oleksandr S. Liashuk, Anastasiia M. Hurieva, Dmytro Lesyk, Yuliia Holota, Petro Borysko, Svitlana V. Shishkina, Dmytro M. Volochnyuk, Oleksandr O Grygorenko
Convenient synthetic approaches to a series of fluorinated bicyclic piperidine analogs (including 3-fluoro-, 3,3-difluoro-, 3-carboxy-3-fluoro-, and 3-trifluoromethyl-substituted 6-azabicyclo[3.1.1]heptanes) were proposed. Using commercially available fluorination agents, the target building blocks were prepared in gram to decagram scale in a single run. Evaluation of pKa and LogP values revealed
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Chemoselective Synthesis of Tetrahydropyrimidines and Dihydropyrrolidones through Three-Component Reaction of Amines, 1,3,5-Triazinanes, and Alkyne Esters Eur. J. Org. Chem. (IF 2.5) Pub Date : 2025-02-07 Wen-Kang Wang, Jian Zheng, Sheng-Yin Zhao
A three-component reaction of amines, 1,3,5-triazinanes, and alkyne esters for the construction of tetrahydropyrimidines and dihydropyrrolidones derivatives was reported. Shifting the substituent group of 1,3,5-triazinanes led to the chemoselective synthesis. As three-atom synthons, aryl substituted 1,3,5-triazinanes were applied to the regioselective synthesis of tetrahydropyrimidines. Alkyl substituted
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Synthesis of Benzoxazoles by Metal‐Free Oxidative Cyclization of Catechols with Amines Eur. J. Org. Chem. (IF 2.5) Pub Date : 2025-02-07 Feng Liu, Wan Wang, Jianyu Dong, Shaofeng Wu, Lebin Su, Yongbo Zhou
Benzoxazoles are crucial in pharmaceuticals, agrochemicals, and functional materials. Their simple, economical, green, and efficient synthesis has attracted long‐standing interest in synthetic chemistry. Herein, we present an extremely simple strategy for constructing benzoxazoles via the direct oxidative cyclization of readily available catechols and primary amines, using DDQ/EA and O₂/water oxidative
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Strategies for modification of tryptophan residues: recent advances and future perspectives in photo‐/ electrochemical‐induction, and metal catalysis Eur. J. Org. Chem. (IF 2.5) Pub Date : 2025-02-07 Chaochao Zhang, Jun Huang, Shun Li, Fujin Huo, Yue Weng
Recent advancements in tryptophan (Trp) modification have greatly expanded its applications across drug discovery, materials science, and environmental monitoring. Trp, an essential amino acid with a unique indole ring, serves as an ideal target for chemical modification due to its redox‐active nature. Photo‐ and electrochemical methods, which utilize light and electric energy, respectively, offer
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Effect of Substituents on the Tautomerism of Pyridone Nucleoside Analogs Eur. J. Org. Chem. (IF 2.5) Pub Date : 2025-02-06 Leon Stark, Patrik Zielinski, Burkhard Miehlich, Shangqing Yang, Wolfgang Frey, Ralf Bartenschlager, Andreas Koehn, Clemens Richert
Nucleobase analogs are important tools in medicine and chemical biology, as they offer molecular targeting options for the intervention in genetic processes. Pyridone C‐nucleosides have been shown to pair with adenine in complementary strands, but a switch from the lactam to lactim form may change their base pairing preference. We synthesized 6‐fluoropyridone analogs of aciclovir and cidofovir, which
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Recent Advances in the Photochemical Synthesis of Esters Eur. J. Org. Chem. (IF 2.5) Pub Date : 2025-02-06 Jie Li, Da-Liang Zhu, David James Young, Yanqing Wang, Hong-Xi Li
Photoredox catalysis has recently emerged as a powerful synthetic tool for making a variety of carbon‐carbon and carbon‐heteroatom bonds. The development of esterification reactions induced by light is an atom economical and energy efficient alternative to traditional methods for the synthesis of esters, with benefits including mild reaction conditions, high chemical yields, and wide functional group
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Mannitol‐based CO Surrogate for Palladium‐Catalyzed Alkoxycarbonylation Eur. J. Org. Chem. (IF 2.5) Pub Date : 2025-02-06 Zhen-Wei Liu, Hefei Yang, Zhi-Peng Bao, Jiajun Zhang, Xiao-Feng Wu
Carbonylative transformation is already been accepted as a powerful toolbox in synthetic chemistry. However, the manipulation of toxic and smell‐less carbon monoxide gas lagged it from wide range applications. Hence the developing of new and efficient CO surrogates become an attractive topic. Herein, we developed a novel mannitol‐based carbon monoxide surrogate with an enhanced carbon monoxide loading
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Synthesis of Vinyl Boronates from Aldehydes and Ketones by Peterson Olefination: Investigation of the Peterson/Boron‐Wittig Chemoselectivity Eur. J. Org. Chem. (IF 2.5) Pub Date : 2025-02-06 Julien Janssens, Guillaume Berionni, Raphael Robiette
We report our results on the development of the Peterson olefination using gem‐borylsilylmethane derivatives to synthesize di‐ and tri‐substituted vinyl boronates. We show that the electronic properties of the carbonyl partner have no effect on the Peterson/boron‐Wittig chemoselectivity whereas the nature of the silane group plays an important role. A DFT study helps explain observed reactivity, chemoselectivity
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Regioselective Synthesis of n‐Nonanal and Aldehyde‐Containing Polysiloxanes via Rh‐Catalyzed Hydroformylation Enhanced by A New Silicon‐Tethered Multidentate Phosphine Ligand Eur. J. Org. Chem. (IF 2.5) Pub Date : 2025-02-06 Shu-Yuan Tian, Lin Shi, Jun-Hui Zhu, Li Li, Fei Ye, Zheng Xu, Li-Wen Xu
Catalytic synthesis of long‐chain alkyl aldehydes presents a significant challenge in homogeneous catalysis and organic synthesis due to the difficulty in regioselective control. Here we report a rhodium‐catalyzed high chemo‐ and regio‐selective hydroformylation of 1‐octene that would be highly useful intermediates in chemical industry. Notably, the easy made tetradentate P‐ligands L1 and L2 can effectively
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NHC‐Free Ketone Synthesis via Radical Coupling Mechanisms Eur. J. Org. Chem. (IF 2.5) Pub Date : 2025-02-05 Lifeng Wang, Yuxing Cai, Yong Huang
Ketone synthesis via radical coupling mechanisms has recently gained significant attention. Traditionally, these methods have relied on N‐heterocyclic carbenes (NHCs) to generate the key ketyl radical intermediate, either through single‐electron reduction of acyl azolium or single‐electron oxidation involving the Breslow intermediate. In this report, we introduce a novel photoredox protocol that directly
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Amino Acid‐Mediated Enantioselective Synthesis of a Bicyclic Ketocarbaldehyde: Theoretical and Experimental Insights into a Key Intermediate for Some Polycyclic Diterpene Synthesis Eur. J. Org. Chem. (IF 2.5) Pub Date : 2025-02-05 Francesca Leonelli, Fabrizio Vetica, Enrico Bodo, Stefano Russo, Lorenzo Michelini, Elisa Sturabotti, Giulia Mazzoccanti, Alessia Ciogli, Nicola Demitri, Doriano Lamba, Annalisa Masi, Luisa Maria Migneco, Rinaldo Marini Bettolo
A study on the amino acid‐mediated intramolecular cyclization of diketoaldehyde 2 to form bicyclic ketocarbaldehyde 1, a potentially useful intermediate in the synthesis of some polycyclic diterpenes, is hereafter presented. This cyclization exhibits a peculiar enantio‐selectivity if compared to similar intramolecular cyclizations due to its product being the (S)‐enantiomer when using d‐amino acids
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Cu‐catalyzed Bilateral Linkage of Sulfenamides for the Constructionof Cyclic Sulfilimines Eur. J. Org. Chem. (IF 2.5) Pub Date : 2025-02-04 Xinyu Zhang, Rutian Sun, Daming Zeng, Ming Wang, Xuefeng Jiang
A CuI‐catalyzed bilateral linkage of S‐phenethyl‐sulfenamides with cyclic diaryliodonium salts was developed for the one‐step construction of cyclic sulfilimines. The challenging cyclic sulfoximines can be efficiently obtained via subsequent oxidation. Photophysical properties and DFT calculations reveal that cyclic sulfoximines, compared to cyclic sulfilimines and sulfones, exhibit larger Stokes shifts
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Regio‐ and Stereo‐Selective Ring Opening of Cyclopropenes with Triflic Acid: en Route to Vinyl Triflates Eur. J. Org. Chem. (IF 2.5) Pub Date : 2025-02-04 Shu-Ya Xin, Qian Wang, Fei Wang
Herein, we report a triflic acid‐mediated ring opening of cyclopropenes, affording vinyl triflates with high regio‐ and stereo‐selectivity. An intramolecular halogen transfer reactivity was also observed in this reaction, offering a tool to access the valuable vinyl chloride and bromide. The vinyl triflate products are applicable to palladium‐catalyzed cross coupling reactions, delivering various trisubstituted
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Organic Transformations Utilizing 1,5,7‐Triazabicyclo[4.4.0]dec‐5‐ene (TBD): A Tale of Two Nitrogens Eur. J. Org. Chem. (IF 2.5) Pub Date : 2025-02-03 Chunling Blue Lan, Karine Auclair
1,5,7‐Triazabicyclo[4.4.0]dec‐5‐ene (TBD) is a bicyclic guanidine with booming applications. Bearing both a nucleophilic nitrogen and an electrophilic nitrogen, TBD is a multifunctional and versatile reagent that is able to promote a variety of organic transformations. Although advancements with TBD in the polymer field have been well reviewed and documented, summaries that focus on synthetic methodologies
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Front Cover: Solvent‐Induced Amplification of Chiral Superstructures of Carbazole Porphyrins in Dynamic Supramolecular Aggregates (Eur. J. Org. Chem. 5/2025) Eur. J. Org. Chem. (IF 2.5) Pub Date : 2025-02-03 Pooja V. Shreechippa, Dinesh N. Nadimetla, Avinash L Puyad, Ambadas B. Rode, Sheshanath V. Bhosale
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Regioselective Hydroformylation of α,β‐Unsaturated Esters: Impact of Reaction Parameters & Reaction Optimization Eur. J. Org. Chem. (IF 2.5) Pub Date : 2025-02-01 Hannah Bork, Harald Gröger
The hydroformylation of α,β‑unsaturated esters represents a highly atom‐economical route towards β‑aldehydes with the potential application as precursors for derivatization to pharmaceuticals such as (R)‑Baclofen or Pregabalin. Methyl 4‐chlorocinnamate as an α,β‑unsaturated ester has been rarely studied in hydroformylation, particularly with regard to a parameter screening for reaction optimization
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Catalyst-Free Visible Light-Induced N−N Bond Cleavage for the Synthesis of Iminophosphorane Using Triarylphosphine and N-Sulfonyl and N-Acylaminopyridinium Salt Eur. J. Org. Chem. (IF 2.5) Pub Date : 2025-02-01 Xiaotao Qin, Chenglei Yang, Yinjiang Xue, Jinkai Hu, Jinhui Yang, Dianjun Li
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An approach to functionalization of cucurbit[n]uril through a tetrahydrothiopheno equatorial substituent Eur. J. Org. Chem. (IF 2.5) Pub Date : 2025-01-31 Anthony Ivan Day, Ahmed Abdulrahman, Mohamed M. S. Hamoud, Vijaybabu Mandadapu, Yi Zhao, Minghua Chen
A tetrahydrothiopheno equatorial substituent on a glycoluril moiety of a cucurbit[n]uril was found to be robust and provided a capacity for reactive derivatization. We have demonstrated this on tetrahydrothiopheno substituted glycoluril derivatives as a proof of concept, then translatable reactions were applied to tetrahydrothiopheno substituted cucurbituril homologues 7 and 8. In addition to the successful
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Synthesis of β-Aminoketones via Arylboronic Acid Catalyzed Decarboxylative Mannich Reactions of Enamines and β-Ketoacids Eur. J. Org. Chem. (IF 2.5) Pub Date : 2025-01-30 Beining Wang, Yiding Wang, Jun Li, Liuying Zhao, Junyu Wang, Xinyu Wei, Xiangyang Yuan, Haipeng Hu
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Recent Developments for the Ring Opening of Pyrrolidines and Unstrained Cyclic Amines via C–N Bond Cleavage Eur. J. Org. Chem. (IF 2.5) Pub Date : 2025-01-30 Eisuke Ota, Junichiro Yamaguchi
In recent years, the deconstructive transformation of unstrained cyclic amines via C–N bond cleavage has emerged as a powerful strategy for expanding chemical space and facilitating the synthesis of structurally diverse molecules. Notably, advancements in the C–N bond cleavage of pyrrolidine and other unstrained cyclic amines have highlighted the significant potential of this approach in modern organic
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Halogen-Mediated Electrochemical C−N Bond Construction of Amine Eur. J. Org. Chem. (IF 2.5) Pub Date : 2025-01-28 Yu-Yang Xie, Zhang Zhang, Ying-Chun Wang
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An Operationally Simple, Regioselective, Platinum-Catalyzed Hydroboration of Unactivated Alkynes Eur. J. Org. Chem. (IF 2.5) Pub Date : 2025-01-27 K. Lawrence E. Hale, Dean D. Roberts, Mark G. McLaughlin
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Front Cover: (Eur. J. Org. Chem. 4/2025) Eur. J. Org. Chem. (IF 2.5) Pub Date : 2025-01-27 Joana R. M. Ferreira, Bruna F. L. Guerreiro, Fábio M. F. Santos, Samuel Guieu, M. Manuel B. Marques
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Photoinduced DNA Cleavage Using Bioinspired Photostable Flavin Analogues Eur. J. Org. Chem. (IF 2.5) Pub Date : 2025-01-26 Dipayan Mondal, Ashutosh Kumar Mishra
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Modern Approaches for Asymmetric Construction of CF3-All Carbon Quaternary Stereocenters from Prochiral Trifluoromethyl Alkenes Eur. J. Org. Chem. (IF 2.5) Pub Date : 2025-01-26 Chiliveru Priyanka, Raju Adepu, Nagender Punna
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C−C Coupling of Ketones with Ethanol and Methanol Enabled by Nickel Catalysis Eur. J. Org. Chem. (IF 2.5) Pub Date : 2025-01-25 Motahar Sk, Adrija Ghosh, Lalit Mohan Kabadwal, Debasis Banerjee
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Base-Promoted Tandem Synthesis of 6-H-Phenanthridine and its Derivatives Eur. J. Org. Chem. (IF 2.5) Pub Date : 2025-01-25 Haoyu Jin, Min Zeng, Shouliang Wang, Yitian Ding, Suyang Chen, Jinxi Feng, Xianhao Chen, Tingting Miao, Fen Wu, Qian Shi
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A Two‐step, One‐pot Baeyer‐Villiger oxidation of Biomass‐derived Levoglucosenone Derivatives to Chiral, C4‐Sustituted 5‐Hydroxymethyl Butyrolactones Eur. J. Org. Chem. (IF 2.5) Pub Date : 2025-01-24 Christopher William James Murnaghan, Andrew Cummings, Clare Rice, Gary N. Sheldrake
A two‐step one‐pot rapid microwave assisted method has been developed for the Baeyer‐Villiger oxidation of biomass derived levoglucosenone (LGO) analogues. This method uses the acidic resin Amberlyst 15 as the catalyst and hydrogen peroxide as the oxidant in ethanol solution. A small library of C4‐substituted LGO analogues have been synthesised and oxidised using this method giving high yields in short
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Synthesis of Sulfone Containing-Spirocycles, -Pentafulvene Dyes and Their Photophysical Properties Eur. J. Org. Chem. (IF 2.5) Pub Date : 2025-01-24 Gitanjali Mishra, Potnuru Indu, Mukesh Sasmal, Barla Thirupathi
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One-Pot Synthesis of Fluorinated Pyrimidine Derivatives from Aldehydes by Photocatalytic α-Perfluoroalkenylation Eur. J. Org. Chem. (IF 2.5) Pub Date : 2025-01-24 Yu-Jun Zhu, Constantin Czekelius
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Chiral Thiourea Catalyzed Enantioselective Cascade Synthesis of 2,3-Dihydrobenzofurans Eur. J. Org. Chem. (IF 2.5) Pub Date : 2025-01-24 Akanksha Kumari, Anshul Jain, Nirmal K. Rana
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Synthesis of 4-Iodoimidazole Nucleosides: A Biocatalyzed Whole Cell Approach Eur. J. Org. Chem. (IF 2.5) Pub Date : 2025-01-23 Lautaro A. M. Giaimo, Leticia Lafuente, Romina N. Fernández Varela, Matías L. Nóbile, Adolfo M. Iribarren, Elizabeth S. Lewkowicz
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Guaiacylglycerol as an Intermediate in Vanillin Production during Oxidative Conversion of Guaiacyl Lignin under Alkaline Conditions Eur. J. Org. Chem. (IF 2.5) Pub Date : 2025-01-23 Takuya Hayashi, Ayami Ishikawa, Takashi Hosoya, Hisashi Miyafuji
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Recent Advances in Radical Hydrofunctionalization of Alkenes and Dienes via Reductive Metal‐Hydride Hydrogen Atom Transfer (MHAT) Eur. J. Org. Chem. (IF 2.5) Pub Date : 2025-01-23 Haigen Shen, Xianrong Zeng, Zhaobin Wang
The metal‐hydride hydrogen atom transfer strategy (MHAT) has emerged as a robust approach for the radical hydrofunctionalization of alkenes, demonstrating exceptional functional group tolerance and chemoselectivity. Traditional methods for generating metal‐hydride (M‐H) species typically require oxidative conditions that depend on stoichiometric oxidants and hydride donors, posing challenges to sustainability
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Diethylaluminium Chloride-Mediated Cycloaddition/Conjugate Reduction Sequence towards Imido-Substituted Norbornenes Eur. J. Org. Chem. (IF 2.5) Pub Date : 2025-01-22 Manuel Kirchhof, Derman Batman, Elliot Nicholas, Wolfgang Frey, Volker Derdau, Anna Zens, Sabine Laschat
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Synthesis of Indole-Fused Chromane-Based Spirooxindoles via Brønsted Acid-Catalyzed Regioselective [5+1] Annulation Eur. J. Org. Chem. (IF 2.5) Pub Date : 2025-01-22 Le-Hua Ye, Xiao Cheng, Zi-Qi Zhu, Feng Shi
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Cardo Bisphenol Fluorene Fused with Dibenzo[g,p]chrysene for a High Refractive Index Monomer Eur. J. Org. Chem. (IF 2.5) Pub Date : 2025-01-22 Toko Yura, Rion Noda, Ikuma Okada, Zhenfeng Guo, Takashi Nakanishi, Yousuke Yamaoka, Tetsuo Iwasawa
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Catalytic Asymmetric Addition and Substitution Reactions with Grignard Reagents: Do We Know It All? Eur. J. Org. Chem. (IF 2.5) Pub Date : 2025-01-22 Siriphong Somprasong, Juana M. Pérez, Marta Castiñeira Reis
Catalysis has been a cornerstone in organic synthesis, enabling a variety of highly efficient and selective C–C bond formation reactions, in particular enantioselective addition and substitution of Grignard reagents. Throughout time, we have gained significant understanding into how various factors, such as the influence of the metal source, the nature of the ligands, the substrates or temperature
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A P-nucleophile Interrupted Seyferth-Gilbert Reaction Eur. J. Org. Chem. (IF 2.5) Pub Date : 2025-01-21 Yuan-Jie Wei, Fei-Long Zhou, Yan Tian, Yong-Feng Cheng
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Metal-Free and Diastereoselective Synthesis of 4-Oxa-δ-Lactams with 2-Aza-3-Silyloxy-1,3-Butadienes and Fluoroalkyl Acylsilanes Eur. J. Org. Chem. (IF 2.5) Pub Date : 2025-01-21 Dalu Song, Yunxiao Zhang, Xiaoqian He, Gang Zhou, Weilu Zhang, Xiao Shen
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Enantioselective Construction of Tetrahydro-α-Carbolines via Organocatalytic Friedel-Crafts Alkylation/N-Hemiacetalization of 2-Aminoindoles with Enals Eur. J. Org. Chem. (IF 2.5) Pub Date : 2025-01-21 Xiaochun Liu, Xiang-Feng Ding, Yang-Zi Liu, Wei-Ping Deng
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A Quinidine‐Based Squaramide‐Catalyzed Asymmetric Cascade Double Hetero‐Michael Addition‐Cyclization of N‐Benzylhydroxylamine: Synthesis of Chiral 1,2‐Benzoxazines Eur. J. Org. Chem. (IF 2.5) Pub Date : 2025-01-21 Chandan Kamilya, Dipankar Das, Nikhil L. Gorane, Prasanta Ghorai
The double hetero‐Michael addition (DHMA), leveraging the reactivity of two distinct nucleophilic centers (oxygen and nitrogen), has emerged as a transformative strategy in organic synthesis for constructing carbon‐hetero nuclear bonds in a single step. In this work, we report an innovative intermolecular DHMA cascade cyclization reaction catalyzed by a quinidine‐based squaramide catalyst. The use
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Palladium-Catalyzed Heck-Matsuda Reaction of Morita-Baylis-Hillman Alcohols with Aryl Triazenes: Unexpected Role of Nitric Acid as the Promoter Eur. J. Org. Chem. (IF 2.5) Pub Date : 2025-01-17 Yue Shen, Mengni Pan, Daming Liu, Hui You, Xinying He, Yang Li, Chaoren Shen, Mengmeng Zhao, Wanfang Li
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Catalyst‐Free Depolymerization of Aromatic and Aliphatic Polyesters Using Me3SiI Eur. J. Org. Chem. (IF 2.5) Pub Date : 2025-01-17 Thibault Cantat, Jean-Claude BERTHET, Marie KOBYLARSKI, Xin LIU
Me3SiI promotes the depolymerization of some alkyl and aromatic polyesters in the absence of catalyst. The monomer products and/or their value‐added derivatives are obtained in high yields. The reaction outcomes are influenced by the solvent choice , temperature and the amount of Me3SiI. The depolymerization of PES gives succinic anhydride. With PLA the ester CH3CH2CO2SiMe3 and propionyl iodide (CH3CH2COI)
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Ring Opening and C(ω)-S Coupling: Nickel-Mediated Transformation of Alicyclic Alkoxyhydroperoxides Eur. J. Org. Chem. (IF 2.5) Pub Date : 2025-01-17 Dmitri I. Fomenkov, Roman A. Budekhin, Olga M. Mulina, Olga A. Komarova, Mikhail M. Doronin, Yulia Yu. Belyakova, Liang-Nian He, Ivan A. Yaremenko, Alexander O. Terent'ev
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Design and Synthesis of a Sialic Acid-Derived Tracer for 18F-PET Multiple Sclerosis Imaging Eur. J. Org. Chem. (IF 2.5) Pub Date : 2025-01-17 Kathrin Siebold, Lea Göbel, Christian Paul Konken, Andreas Faust, Ryan Gilmour
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Oxygen Atom Migration of Allylic Esters via an Organocatalyzed Claisen-type Rearrangement Eur. J. Org. Chem. (IF 2.5) Pub Date : 2025-01-16 Xiaoli Wang, Ke Liu, Xudong Jin, Xin Li, Mingyu Shen, Sheng Zhang, Man-Bo Li
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Manganese-Catalyzed Selective ortho-Deuteration of Aromatic Amidines with D₂O Eur. J. Org. Chem. (IF 2.5) Pub Date : 2025-01-16 Jian-Fei Bai, Hao Hu, Yanran Liu, Zhi-Jiang Jiang, Jia Chen, Zhanghua Gao
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Determination of the pKaH of Established Isothiourea Catalysts Eur. J. Org. Chem. (IF 2.5) Pub Date : 2025-01-16 Lukas S. Vogl, Matthias Bechmann, Mario Waser
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Releasing Intramolecular Stress of Curved Fused-Core to Enhance N-Type Carrier Transport Performance in A-D-A’-D-A Type Non-Fused Small Molecule Eur. J. Org. Chem. (IF 2.5) Pub Date : 2025-01-14 Hua Sun, Wenju Li, Qin Zhou, Jing Zhang, Qichun Zhang