In search for a new synthetic pathway for azoxybenzenes with different substitution patterns, an approach using a microfluidic reactor with gel‐bound proline organocatalysts under continuous flow is presented. Herein the formation of differently substituted azoxybezenes by reductive dimerization of nitrosobenzenes within minutes at mild conditions in good to almost quantitative yields is described

A mild and convenient protocol for the a‐hydroxylation of a‐substituted malonates, b‐ketoesters and b‐ketoamides is disclosed. Cheap and stable magnesium monoperphthalate (MMPP) was effective for a first direct a‐hydroxylation protocol of the Rubottom oxidation, providing tartronic esters, cyclic a‐hydroxy b‐ketoesters and amides in good to high yields, when working at room temperature and in ethanol

A regioselective gold (I)‐catalyzed approach for the construction of polycyclic chromene cores has been developed. The reaction proceeds in good to excellent yields under mild condition with a broad range of substrates providing a simple and efficient tool for the synthesis of pyranochromene derivatives. Moreover, the regiochemical control of the annulation of unsymmetrically substituted propargylic

A series of 4‐aryl‐2‐imino‐1,3‐dithiolanes was synthesized by means of a straightforward strategy starting from readily available precursors: reactions of dithiocarbamates and arylsulfonium salts, at room temperature in water/CH 2 Cl 2 as biphasic medium, afforded the five‐membered cyclic products in good yields. The reaction mechanism was investigated by DFT calculations.

A new C(sp 3 )‐H functionalization reaction consisting in the oxidative α‐allylation of allyl‐ and benzyl‐ methyl ethers has been developed. The C‐C coupling could be carried out under mild conditions thanks to the use of cheap and green oxoammonium salts. The scope of the reaction was studied over 27 examples, considering the nature of the substituents on the two coupling partners.

The huge variety of spirooxindole three‐dimensional scaffolds encompasses relevant bioactive natural alkaloids as well as useful therapeutic agents. In view of the challenging features of the spirooxindole skeletons and their desirable properties, several synthetic routes have been devoted to their preparation. Because of the variety of both 1,3‐dipolar species and 2‐oxindoles bearing a C=X double

For the first time, the challenging atropo‐enantioselective coupling of in‐situ generated arynes and aryllithiums in the presence of a chiral ligand of lithium was investigated. This preliminary study demonstrates the feasibility of this concept, by affording enantioenriched axially chiral biaryls even in the case of products showing a high degree of steric congestion around the newly created aryl‐aryl

A concise stereoselective and protecting group free approaches for the total synthesis of (‐)‐(2 S ,4 R )‐ & (+)‐(2 R ,4 S )‐3'‐methoxyl citreochlorols and their stereoisomers are demonstrated. All four stereoisomers were synthesized to establish the absolute stereochemistry of the reported structures and the structures were revised accordingly. The approach involves chelation controlled regioselective

Two blue thermally activated delayed fluorescence (TADF) emitters bearing di‐ tert ‐butyl carbazoles as the electron donor groups and pyrazine ( DTCz‐Pz ) or dipyrazine ( DTCz‐Pz ) as the electron acceptor are presented. The DFT calculations predict DTCz‐Pz and DTCz‐DPz to possess high S 1 energies (3.19 eV and 3.08 eV, respectively), and relatively large ΔE ST values (0.52 eV and 0.56 eV, respectively)

This review highlights the application of intramolecular Heck reaction in total synthesis of natural products which were synthesized successfully recently (2013 to 2019). Heck cyclization was used as one of the strategic steps for constructions of wide variety of cyclic scaffolds essential for preparation of the different natural products.

The organocatalytic amination of pyrazol‐5‐ones with azodicarboxylates (catalyzed by quinine) is reported. This asymmetric process furnishes enantiomerically enriched hydrazine adducts containing quaternary stereocenters in high yields (74‐96%) and enantioselectivities (up to ee 97%). Theoretical calculations allow us to propose the relations between quinine catalyst and reactants leading to observed