The use of molecular balances allows for dissecting competing solvent effects from hydrogen bonding interactions.

Chemistry degrees are often very broad. What might a degree look like if we covered fewer topics more deeply?

Solid-state synthesis provides a route to more sustainable fertilizer.

Boroles can be irradiated with light to form borapyramidanes. The two boron-containing structures are found to have a close chemical relationship.

R/S Chemistry is a free, game-based learning tool for students to practise stereochemical assignments in an interactive setting, leading to increased student engagement in the topic.

The rational design of a novel fluorinated ethereal solvent shows a promising direction towards compact and lightweight batteries.

The lower solvation of phenol at the air–water interface speeds up its photoionization.

Convenient synthesis of planar-chiral rhodium catalysts enables asymmetrical C–H activation.

As academic staff scrambled into emergency remote teaching during COVID-19 restrictions, we also had to move in-person exams online without compromising integrity. This disruption caused us to think carefully about how chemistry is assessed, because ‘business as usual’ was no longer possible — and at some institutions, there are no plans for in-person exams to return.

Protein structure and interactions can be characterized in cells using 19F NMR.

Polyarylenes are now afforded through the cycloaromatization of isopropyl-substituted arenes on Au surfaces. The reaction mechanism is elucidated through computational and in situ scanning probe microscopy investigations.

Our remodelled research agenda suggests setting priorities that outline a clear framework for making decisions on current and future research activities. We propose collaborative and collective global approaches to maximize our joint efforts, especially among early-career researchers (ECRs), to remodel research agendas for the ultimate benefit of humanity. Our remodelled research agenda suggests setting

Chemists make crucial contributions to society and are often found in a broad range of workplaces. To sustain these impactful contributions, a diverse range of career skills must be embedded into the curricula.

A student-designed, student–faculty partnership was piloted to increase representation from diverse voices in the faculty hiring process while also rebuilding trust between faculty and students.

Numerous studies show that gender-based bias affects the distribution of research funding, with researcher-focused assessments being particularly prone to bias. Considering the negative impact on science when bias intrudes on funding decisions, granting agencies need to improve their efforts to document, monitor and reduce it.

Drying DNA with crystalline calcium phosphate can help boost its stability.

Virtually all prospective medical students are required to take courses in general and organic chemistry, but are they really necessary? We discuss the relevance of chemistry to modern medicine and the arguments for and against its use as an essential prerequisite.

The world is facing multiple unfolding global crises and chemistry systems are integral in both the cause and solution to these challenges. Systems thinking can be used not only to support student learning of chemistry concepts, but also to build community within and beyond the classroom.

Correction to: Nature Reviews Chemistry https://doi.org/10.1038/s41570-021-00345-7, published online 14 January 2022. In the text and in Fig. 6a of the originally published version, we inadvertently misnamed the corresponding authors of ref. . This has now been corrected in all versions of the article. https://doi.org/10.1038/s41570-022-00374w | Published online xx xx xxxx © Springer Nature Limited

Integrating bio- and chemocatalysis in one-pot enabled new reaction pathways to amides with broad substrate scope and enantioselectivity under mild conditions, building towards more sustainable chemistry.

No matter your career stage, pregnancy in the lab raises complex questions — and definitive answers are hard to come by. In conversation with members of Women in Supramolecular Chemistry (WISC) , we share our experience, discuss research into the challenges and move the conversation to the support needed by people who are pregnant. We conclude that community is critical to improve experiences.

The application of computational tools in the study of natural products continues its inexorable rise. A recent report describing an asymmetric total synthesis of resveratrol oligomers provides an example in which computation played an integral role.

A simple processing procedure enables the fabrication of biodegradable protein-based plastics with tunable properties.

By understanding the magnetic properties of purely organic thin films, opportunities are presented to employ new characteristics in myriad applications.

Glycosylation of proteins can stabilize folding intermediates and thus enable the total synthesis of correctly folded disulfide-rich proteins.

Advanced 17O NMR methods can help distinguish oxygen atoms from different hydrogen-bonding environments in glucose.

Alterations in protein structure may have profound effects on biological function. Analytical techniques that permit characterization of proteins while maintaining their conformational and functional state are crucial for studying changes in the higher order structure of proteins and for establishing structure–function relationships. Coupling of native protein separations with mass spectrometry is

A review of Arieh Warshel’s autobiography, where he describes his life from childhood to when he fascinates about understanding the catalytic power of enzymes.

While there is much of the last two years we may wish to forget, it is imperative that we share our pandemic chemistry teaching experiences.

A rearrangement reaction — a classic of traditional organic synthesis — has been applied to a polymer, enabling conversion of a polyester to a vinyl polymer.

Cyanuric acid (CA) derivatives can co-assemble with polyadenine sequences to form a triple helical DNA-based structure bearing functional groups able to guide higher ordered architectures.

Using ammonium bicarbonate as an additive can boost the reactivity of amines with carbon dioxide in microdroplet reactions.

In two seminal papers published 25 years ago, Phillips and Remington reported the structure of the green fluorescent protein (GFP). These studies provided a blueprint for the rational engineering of GFP, catalysing efforts that produced a large and growing collection of fluorescent proteins and indicators of cellular activity.

Climate change is a chemical problem and chemistry and chemical engineering can provide some of the solutions. What kind of chemistry should we be doing?

The COVID-19 pandemic has had a dramatic impact on the way we do research. Here, I share an approach to rebuild research capacity in a new collaborative fashion termed ‘teamlets’. Teamlets enable a team-based approach to boost morale, increase data integrity, faciliate interdisciplinarity and ensure continuity of expertise.