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Inhibition of RNA-binding proteins with small molecules Nat. Rev. Chem. (IF 34.953) Pub Date : 2020-07-15 Peng Wu
Protein–RNA interactions have crucial roles in various cellular activities, which, when dysregulated, can lead to a range of human diseases. The identification of small molecules that target the interaction between RNA-binding proteins (RBPs) and RNA is progressing rapidly and represents a novel strategy for the discovery of chemical probes that facilitate understanding of the cellular functions of
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Charge-transfer processes in metal complexes enable luminescence and memory functions Nat. Rev. Chem. (IF 34.953) Pub Date : 2020-07-13 Vivian Wing-Wah Yam; Alan Kwun-Wa Chan; Eugene Yau-Hin Hong
Molecular transition-metal–ligand complexes are emerging as useful paradigms in materials science. Transition metal complexes have diverse metal d electron configurations, oxidation states, coordination numbers and geometries such that they can undergo a diverse array of electronic transitions. Metal-to-ligand charge-transfer transitions and their associated excited states are especially attractive
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Contain your excitement Nat. Rev. Chem. (IF 34.953) Pub Date : 2020-07-08 Gabriella Graziano
Vibronic coherences can guide a synthetic control of the lifetime of the excited states in iron(ii)-based complexes.
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Feeling the effects Nat. Rev. Chem. (IF 34.953) Pub Date : 2020-07-07 Stephen G. Davey
Experimental models show that through-space effects dominate over through-bond effects when considering the influence of so-called electron-withdrawing or electron-donating substituents on molecular conformation and reactivity.
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Exploiting chemistry and molecular systems for quantum information science Nat. Rev. Chem. (IF 34.953) Pub Date : 2020-07-07 Michael R. Wasielewski; Malcolm D. E. Forbes; Natia L. Frank; Karol Kowalski; Gregory D. Scholes; Joel Yuen-Zhou; Marc A. Baldo; Danna E. Freedman; Randall H. Goldsmith; Theodore Goodson; Martin L. Kirk; James K. McCusker; Jennifer P. Ogilvie; David A. Shultz; Stefan Stoll; K. Birgitta Whaley
The power of chemistry to prepare new molecules and materials has driven the quest for new approaches to solve problems having global societal impact, such as in renewable energy, healthcare and information science. In the latter case, the intrinsic quantum nature of the electronic, nuclear and spin degrees of freedom in molecules offers intriguing new possibilities to advance the emerging field of
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Iron and manganese oxo complexes, oxo wall and beyond Nat. Rev. Chem. (IF 34.953) Pub Date : 2020-07-02 Virginia A. Larson; Beatrice Battistella; Kallol Ray; Nicolai Lehnert; Wonwoo Nam
High-valent metal–oxo species with multiply-bonded M–O groups have been proposed as key intermediates in many biological and abiological catalytic oxidation reactions. These intermediates are implicated as active oxidants in alkane hydroxylation, olefin epoxidation and other oxidation reactions. For example, [FeivO(porphyrinato•−)]+ cofactors bearing π-radical porphyrinato•− ligands oxidize organic
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From self-replication to replicator systems en route to de novo life Nat. Rev. Chem. (IF 34.953) Pub Date : 2020-07-01 Paul Adamski; Marcel Eleveld; Ankush Sood; Ádám Kun; András Szilágyi; Tamás Czárán; Eörs Szathmáry; Sijbren Otto
The process by which chemistry can give rise to biology remains one of the biggest mysteries in contemporary science. The de novo synthesis and origin of life both require the functional integration of three key characteristics — replication, metabolism and compartmentalization — into a system that is maintained out of equilibrium and is capable of open-ended Darwinian evolution. This Review takes
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The periodic table and the physics that drives it Nat. Rev. Chem. (IF 34.953) Pub Date : 2020-06-29 Peter Schwerdtfeger; Odile R. Smits; Pekka Pyykkö
Mendeleev’s introduction of the periodic table of elements is one of the most important milestones in the history of chemistry, as it brought order into the known chemical and physical behaviour of the elements. The periodic table can be seen as parallel to the Standard Model in particle physics, in which the elementary particles known today can be ordered according to their intrinsic properties. The
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Balancing the hydrogen books Nat. Rev. Chem. (IF 34.953) Pub Date : 2020-06-15 David Schilter
Abiotic sources of H2 in the lithosphere outweigh the sinks, with the balance potentially being available to a large microbial community.
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Making germanes relevant in cross-coupling Nat. Rev. Chem. (IF 34.953) Pub Date : 2020-06-15 Stephen G. Davey
Although they are generally poor coupling agents under palladium catalysis, germanes are easily cross-coupled under gold catalysis, enabling a new orthogonal cross-coupling reaction.
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Exploring chemical compound space with quantum-based machine learning Nat. Rev. Chem. (IF 34.953) Pub Date : 2020-06-12 O. Anatole von Lilienfeld; Klaus-Robert Müller; Alexandre Tkatchenko
Rational design of compounds with specific properties requires understanding and fast evaluation of molecular properties throughout chemical compound space — the huge set of all potentially stable molecules. Recent advances in combining quantum-mechanical calculations with machine learning provide powerful tools for exploring wide swathes of chemical compound space. We present our perspective on this
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Solving a solubilty problem Nat. Rev. Chem. (IF 34.953) Pub Date : 2020-06-08 Gabriella Graziano
Despite their similarity with surfactants, the mechanism by which hydrotropes assist in solubilizing apolar molecules in water is not totally understood. A mechanism is now proposed that identifies apolar interactions as driving forces of hydrotropy, in agreement with a statistical thermodynamic picture.
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Broadening the scope of biocatalytic C–C bond formation Nat. Rev. Chem. (IF 34.953) Pub Date : 2020-06-03 Lara E. Zetzsche; Alison R. H. Narayan
Enzymes exercise impeccable control over chemoselectivity, site selectivity and stereoselectivity in reactions they mediate, such that we have witnessed a surge in the development of new biocatalytic methods. Although carbon–carbon (C–C) bonds are the central framework of organic molecules, biocatalytic methods for their formation have largely been limited to a select few lyase enzymes. Thus, despite
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Dial in your dispersity Nat. Rev. Chem. (IF 34.953) Pub Date : 2020-05-27 David Schilter
One can combine two distinct chain-transfer agents to tune the dispersity of vinyl polymers. The polymer chains remain living and can be transformed into diblock copolymers.
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Stabilization strategies in biomass depolymerization using chemical functionalization Nat. Rev. Chem. (IF 34.953) Pub Date : 2020-05-22 Ydna M. Questell-Santiago; Maxim V. Galkin; Katalin Barta; Jeremy S. Luterbacher
A central feature of most lignocellulosic-biomass-valorization strategies is the depolymerization of all its three major constituents: cellulose and hemicellulose to simple sugars, and lignin to phenolic monomers. However, reactive intermediates, generally resulting from dehydration reactions, can participate in undesirable condensation pathways during biomass deconstruction, which have posed fundamental
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Inverting isomers Nat. Rev. Chem. (IF 34.953) Pub Date : 2020-05-19 Stephen G. Davey
An unexpected epoxide deoxygenation reaction was observed to occur with inversion of stereochemistry and has enabled development of a method for alkene isomerization.
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Author Correction: Advancing photosystem II photoelectrochemistry for semi-artificial photosynthesis Nat. Rev. Chem. (IF 34.953) Pub Date : 2020-05-13 Jenny Z. Zhang; Erwin Reisner
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Fluorescent amino acids as versatile building blocks for chemical biology Nat. Rev. Chem. (IF 34.953) Pub Date : 2020-05-13 Zhiming Cheng; Erkin Kuru; Amit Sachdeva; Marc Vendrell
Fluorophores have transformed the way we study biological systems, enabling non-invasive studies in cells and intact organisms, which increase our understanding of complex processes at the molecular level. Fluorescent amino acids have become an essential chemical tool because they can be used to construct fluorescent macromolecules, such as peptides and proteins, without disrupting their native biomolecular
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Piecing together a structural puzzle Nat. Rev. Chem. (IF 34.953) Pub Date : 2020-05-11
Sample preparation and instrumentation for macromolecular mass spectrometry continue to evolve, making the technique more relevant than ever.
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A controlled attraction Nat. Rev. Chem. (IF 34.953) Pub Date : 2020-05-07 Gabriella Graziano
Uncharged polymers on the surface of charged colloidal particles can help to control their self-assembly into ordered structures.
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Helical polymers for biological and medical applications Nat. Rev. Chem. (IF 34.953) Pub Date : 2020-05-05 Thomas Leigh; Paco Fernandez-Trillo
Helices are the most prevalent secondary structure in biomolecules and play vital roles in their activity. Chemists have been fascinated with mimicking this molecular conformation with synthetic materials. Research has now been devoted to the synthesis and characterization of helical materials, and to understand the design principles behind this molecular architecture. In parallel, work has been done
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Carbonyl trapped in silico Nat. Rev. Chem. (IF 34.953) Pub Date : 2020-05-04 David Schilter
A persistent silylene complex of CO is reminiscent of metal carbonyls and features interesting bonding interactions.
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Orderly as a swarm of bees Nat. Rev. Chem. (IF 34.953) Pub Date : 2020-05-01 Brett F. Thornton
A new book by Peter Wothers delves into the tumultuous history of naming (and symbolizing) the elements.
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Theoretical realities Nat. Rev. Chem. (IF 34.953) Pub Date : 2020-04-15 Alfred C. Chin
An autobiography by Martin Karplus, from his childhood and continuing right through to a journey to Stockholm to receive the 2013 Nobel prize.
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Fingerprints of molecular reactivity Nat. Rev. Chem. (IF 34.953) Pub Date : 2020-04-06 Gabriella Graziano
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Author Correction: Phase engineering of nanomaterials Nat. Rev. Chem. (IF 34.953) Pub Date : 2020-04-06 Ye Chen; Zhuangchai Lai; Xiao Zhang; Zhanxi Fan; Qiyuan He; Chaoliang Tan; Hua Zhang
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Phase engineering of nanomaterials Nat. Rev. Chem. (IF 34.953) Pub Date : 2020-04-01 Ye Chen; Zhuangchai Lai; Xiao Zhang; Zhanxi Fan; Qiyuan He; Chaoliang Tan; Hua Zhang
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Complex polymer architectures through free-radical polymerization of multivinyl monomers Nat. Rev. Chem. (IF 34.953) Pub Date : 2020-03-23 Yongsheng Gao; Dezhong Zhou; Jing Lyu; Sigen A; Qian Xu; Ben Newland; Krzysztof Matyjaszewski; Hongyun Tai; Wenxin Wang
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Bacteria as genetically programmable producers of bioactive natural products Nat. Rev. Chem. (IF 34.953) Pub Date : 2020-03-23 Joachim J. Hug; Daniel Krug; Rolf Müller
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Glycomics studies using sialic acid derivatization and mass spectrometry Nat. Rev. Chem. (IF 34.953) Pub Date : 2020-03-17 Noortje de Haan; Shuang Yang; John Cipollo; Manfred Wuhrer
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Mass spectrometry as a tool to advance polymer science Nat. Rev. Chem. (IF 34.953) Pub Date : 2020-03-06 Kevin De Bruycker; Alexander Welle; Sabine Hirth; Stephen J. Blanksby; Christopher Barner-Kowollik
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Enzymatic degradation of plant biomass and synthetic polymers Nat. Rev. Chem. (IF 34.953) Pub Date : 2020-02-21 Chun-Chi Chen; Longhai Dai; Lixin Ma; Rey-Ting Guo
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Methanogenesis involves direct hydride transfer from H 2 to an organic substrate Nat. Rev. Chem. (IF 34.953) Pub Date : 2020-02-20 Gangfeng Huang; Tristan Wagner; Ulrich Ermler; Seigo Shima
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Single-cell analysis targeting the proteome Nat. Rev. Chem. (IF 34.953) Pub Date : 2020-02-17 Mahmoud Labib; Shana O. Kelley
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Prospects of organic electrode materials for practical lithium batteries Nat. Rev. Chem. (IF 34.953) Pub Date : 2020-02-12 Yong Lu; Jun Chen
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Hollow multishell structures exercise temporal–spatial ordering and dynamic smart behaviour Nat. Rev. Chem. (IF 34.953) Pub Date : 2020-02-11 Jiangyan Wang; Jiawei Wan; Nailiang Yang; Quan Li; Dan Wang
A hollow multishell structure (HoMS) is an assembly of multiple shells with voids between the individual shells. Accessible through nanopores, these voids represent separate reaction environments in the same assembly, such that HoMSs have unique properties that are applicable to diverse fields. These applications have mostly exploited the large specific surface area, high loading capacity and/or buffering
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Methods for generating and screening libraries of genetically encoded cyclic peptides in drug discovery Nat. Rev. Chem. (IF 34.953) Pub Date : 2020-01-17 Catrin Sohrabi; Andrew Foster; Ali Tavassoli
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On the conditions for mimicking natural selection in chemical systems Nat. Rev. Chem. (IF 34.953) Pub Date : 2020-01-14 Grégoire Danger; Louis Le Sergeant d’Hendecourt; Robert Pascal
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Multiphase carbon mineralization for the reactive separation of CO 2 and directed synthesis of H 2 Nat. Rev. Chem. (IF 34.953) Pub Date : 2020-01-14 Greeshma Gadikota
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The role of chemical design in the performance of organic semiconductors Nat. Rev. Chem. (IF 34.953) Pub Date : 2020-01-03 Hugo Bronstein; Christian B. Nielsen; Bob C. Schroeder; Iain McCulloch
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Supramolecular polymerization through kinetic pathway control and living chain growth Nat. Rev. Chem. (IF 34.953) Pub Date : 2019-12-21 Marius Wehner; Frank Würthner
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Advancing photosystem II photoelectrochemistry for semi-artificial photosynthesis Nat. Rev. Chem. (IF 34.953) Pub Date : 2019-12-21 Jenny Z. Zhang; Erwin Reisner
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Mixed up membranes protect protocells Nat. Rev. Chem. (IF 34.953) Pub Date : 2019-12-18 Andrew Bissette
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Silylium ions: from controversial beginnings to useful catalysts Nat. Rev. Chem. (IF 34.953) Pub Date : 2019-11-20 Jay S. Siegel
Silylium ions can be very fleeting — so much so that their isolation was once considered impossible. This prevailing opinion was eventually challenged by chemists brave enough to conduct the challenging experiments that revealed silylium ions to not only be tractable but also synthetically versatile. Although early reports on the existence of silylium ions were met with controversy, we now know how
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The chemistry and applications of RNA 2′-OH acylation Nat. Rev. Chem. (IF 34.953) Pub Date : 2019-11-19 Willem A. Velema; Eric T. Kool
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Stereochemical enhancement of polymer properties Nat. Rev. Chem. (IF 34.953) Pub Date : 2019-07-30 Joshua C. Worch, Hannah Prydderch, Sètuhn Jimaja, Panagiotis Bexis, Matthew L. Becker, Andrew P. Dove
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Publisher Correction: Organocatalysis in aqueous media Nat. Rev. Chem. (IF 34.953) Pub Date : 2019-07-29 Michelle P. van der Helm, Benjamin Klemm, Rienk Eelkema
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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