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Packing in the proteins Nat. Rev. Chem. (IF 34.035) Pub Date : 2021-09-16 Colette Whitfield
Hydrogen-bonded organic frameworks can be employed to encapsulate protein therapeutics for enhanced cell uptake and intracellular biocatalysis.
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Cages within cages Nat. Rev. Chem. (IF 34.035) Pub Date : 2021-09-14 Peter W. Seavill
Homochiral porous cage-in-cage structures that self-assemble from lanthanide cations and chiral amino acid-derived ligands have been prepared and shown to be highly effective in enantioselective separations of small-molecule guests.
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Recent advances in the chemistry and applications of N-heterocyclic carbenes Nat. Rev. Chem. (IF 34.035) Pub Date : 2021-09-03 Peter Bellotti, Maximilian Koy, Matthew N. Hopkinson, Frank Glorius
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A single-molecule blueprint for synthesis Nat. Rev. Chem. (IF 34.035) Pub Date : 2021-08-25 Ilana Stone, Rachel L. Starr, Yaping Zang, Colin Nuckolls, Michael L. Steigerwald, Tristan H. Lambert, Xavier Roy, Latha Venkataraman
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Towards the sustainable discovery and development of new antibiotics Nat. Rev. Chem. (IF 34.035) Pub Date : 2021-08-19 Miethke, Marcus, Pieroni, Marco, Weber, Tilmann, Brönstrup, Mark, Hammann, Peter, Halby, Ludovic, Arimondo, Paola B., Glaser, Philippe, Aigle, Bertrand, Bode, Helge B., Moreira, Rui, Li, Yanyan, Luzhetskyy, Andriy, Medema, Marnix H., Pernodet, Jean-Luc, Stadler, Marc, Tormo, José Rubén, Genilloud, Olga, Truman, Andrew W., Weissman, Kira J., Takano, Eriko, Sabatini, Stefano, Stegmann, Evi, Brötz-Oesterhelt
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NMR spectroscopy probes microstructure, dynamics and doping of metal halide perovskites Nat. Rev. Chem. (IF 34.035) Pub Date : 2021-08-13 Kubicki, Dominik J., Stranks, Samuel D., Grey, Clare P., Emsley, Lyndon
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A complementary pairing Nat. Rev. Chem. (IF 34.035) Pub Date : 2021-08-04 Whitfield, Colette
The supramolecular assembly of oligomers encoded with complementary recognition units enables duplex hybridization with helical structure.
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Interrupted reactions in chemical synthesis Nat. Rev. Chem. (IF 34.035) Pub Date : 2021-08-04 Trudel, Vincent, Tien, Chieh-Hung, Trofimova, Alina, Yudin, Andrei K.
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An alkene dance Nat. Rev. Chem. (IF 34.035) Pub Date : 2021-07-28 Cazin, Catherine S. J.
The seminal paper by Yves Chauvin and Jean-Louis Hérisson on the mechanism of alkene metathesis is elegant, simple and insightful. Published more than 50 years ago, it deserves appreciation and admiration even today.
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Speciation controls selectivity Nat. Rev. Chem. (IF 34.035) Pub Date : 2021-07-22 Jamal A. Malik
Selective cross-coupling at either of two similar halide substituents in a dihalogenated substrate can be achieved by controlling the speciation of the active palladium catalyst.
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A series of selective events Nat. Rev. Chem. (IF 34.035) Pub Date : 2021-07-20 Ana Koperniku
Three unprecedented selective bioconjugation methods for serine, methionine and lysine have been realized. Specifically, chemoselectivity for serine, site-selectivity for methionine and site-specificity for lysine were achieved.
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Scalar coupling scales with bonding Nat. Rev. Chem. (IF 34.035) Pub Date : 2021-07-20 David Schilter
It has so far proved difficult to characterize halogen bonds in solution. A new and simple approach is to use scalar coupling between atoms in a halogen bond donor as a measure of bond strengths with diverse acceptors.
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Transient directing ligands for selective metal-catalysed C–H activation Nat. Rev. Chem. (IF 34.035) Pub Date : 2021-07-20 Nupur Goswami, Trisha Bhattacharya, Debabrata Maiti
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Synthesis of lipid membranes for artificial cells Nat. Rev. Chem. (IF 34.035) Pub Date : 2021-07-19 Kira A. Podolsky, Neal K. Devaraj
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An ancient battle between environment and concrete Nat. Rev. Chem. (IF 34.035) Pub Date : 2021-07-16 Pania Newell
The collapse of the Champlain Towers South condominium in South Florida shocked the world. Many families lost loved ones or are still holding their breath. The question remains: what was the cause of this catastrophic failure? Cementitious materials — not least their reinforcements — are prone to aerobic oxidation, followed by chloride and sulfate attack. These processes jeopardize structures, particularly
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Establishing electron diffraction in chemical crystallography Nat. Rev. Chem. (IF 34.035) Pub Date : 2021-07-13 Tim Gruene, Julian J. Holstein, Guido H. Clever, Bernhard Keppler
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Late-stage C–H functionalization offers new opportunities in drug discovery Nat. Rev. Chem. (IF 34.035) Pub Date : 2021-07-13 Lucas Guillemard, Nikolaos Kaplaneris, Lutz Ackermann, Magnus J. Johansson
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Chemotherapy gets tuned in Nat. Rev. Chem. (IF 34.035) Pub Date : 2021-07-09 Colette Whitfield
Locally activating prodrugs through targeted irradiation — a new concept for concurrent chemotherapy and radiotherapy.
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Re-examining Fenton and Fenton-like reactions Nat. Rev. Chem. (IF 34.035) Pub Date : 2021-07-07 Dan Meyerstein
The Fenton and Fenton-like reactions are important in biology because they are a major source of oxidative stress. The reactions also feature in advanced oxidation technologies to remediate organic pollutants. Unfortunately, these reactions are often simplistically viewed as affording only OH˙ radicals as the active species. Indeed, a variety of additional oxidizing intermediates form, including OR˙
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Surface coating captures droplets Nat. Rev. Chem. (IF 34.035) Pub Date : 2021-06-29 Claire Ashworth
A polymer coating made from cosmetics-based ingredients can be applied to diverse surfaces to capture airborne droplets and mitigate the transmission of infectious respiratory diseases.
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Nitrene transfer catalysts for enantioselective C–N bond formation Nat. Rev. Chem. (IF 34.035) Pub Date : 2021-06-28 Minsoo Ju, Jennifer M. Schomaker
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Highlights and challenges in the selective reduction of carbon dioxide to methanol Nat. Rev. Chem. (IF 34.035) Pub Date : 2021-06-24 Sara Navarro-Jaén, Mirella Virginie, Julien Bonin, Marc Robert, Robert Wojcieszak, Andrei Y. Khodakov
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Water at charged interfaces Nat. Rev. Chem. (IF 34.035) Pub Date : 2021-06-24 Grazia Gonella, Ellen H. G. Backus, Yuki Nagata, Douwe J. Bonthuis, Philip Loche, Alexander Schlaich, Roland R. Netz, Angelika Kühnle, Ian T. McCrum, Marc T. M. Koper, Martin Wolf, Bernd Winter, Gerard Meijer, R. Kramer Campen, Mischa Bonn
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Rearrangements come to Scholl Nat. Rev. Chem. (IF 34.035) Pub Date : 2021-06-23 Qian Miao
Recent findings on the skeletal rearrangement of polycyclic aromatics under oxidative and acidic conditions are envisioned to help development of these Scholl reactions into a more useful and versatile method for synthesizing polycyclic aromatics on the basis of rational design rather than luck.
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The application of modern reactions in large-scale synthesis Nat. Rev. Chem. (IF 34.035) Pub Date : 2021-06-22 Kaitlyn Lovato, Patrick S. Fier, Kevin M. Maloney
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Radical philicity and its role in selective organic transformations Nat. Rev. Chem. (IF 34.035) Pub Date : 2021-06-22 Faeze Parsaee, Milinda C. Senarathna, Prashansa B. Kannangara, Shevon N. Alexander, Phillip Damien E. Arche, Eric R. Welin
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Nickel doesn’t get a slice of the pi Nat. Rev. Chem. (IF 34.035) Pub Date : 2021-06-21 David Schilter
A disilagermirene is a cyclopropene analogue with an unsaturated Si=Ge moiety. Such rings can be generated and stabilized in the presence of Ni, which the Si=Ge group binds through its σ-bond rather than π-bond.
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Deceptive simplicity Nat. Rev. Chem. (IF 34.035) Pub Date : 2021-06-15 Stephen G. Davey
A deep dive into the mechanism of a classic photoredox reaction.
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Discretion is the better part of valence Nat. Rev. Chem. (IF 34.035) Pub Date : 2021-06-10 David Schilter
Laser ablation enables the study of discrete metal difluorides and their reactions with dioxygen and ozone. Metal-fluoride vibrational energies give an indication of the charge on a metal difluoride moiety and help us rationalize the resultant structures.
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A radical departure for supramolecular chemistry Nat. Rev. Chem. (IF 34.035) Pub Date : 2021-06-09 Ali Trabolsi
An experiment that challenged established dogma opened an entirely new avenue for research in the assembly and control of mechanically interlocked compounds.
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Radical-pairing-induced molecular assembly and motion Nat. Rev. Chem. (IF 34.035) Pub Date : 2021-06-09 Kang Cai, Long Zhang, R. Dean Astumian, J. Fraser Stoddart
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A decade of decoding Nat. Rev. Chem. (IF 34.035) Pub Date : 2021-06-03 Soumya Mukherjee, Sujit K. Ghosh
Molecular decoders are single host matrices able to differentiate analytes by their distinct structural accommodations. Ten years ago, Susumu Kitagawa and co-workers described the prototypical molecular decoder and paved the way for molecular sensing. We now revisit this seminal study and discuss some of the advances that have followed.
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Exchange made easy Nat. Rev. Chem. (IF 34.035) Pub Date : 2021-06-01 Stephen G. Davey
A range of aryl and alkenyl organosodium reagents can be prepared by halogen–sodium exchange reactions with neopentylsodium and may be a useful alternative to widely used organolithium reagents.
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Charge frustration in ligand design and functional group transfer Nat. Rev. Chem. (IF 34.035) Pub Date : 2021-05-27 Dominik Munz, Karsten Meyer
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Chemically-powered swimming and diffusion in the microscopic world Nat. Rev. Chem. (IF 34.035) Pub Date : 2021-05-27 Yifei Zhang, Henry Hess
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Bifunctional beginnings Nat. Rev. Chem. (IF 34.035) Pub Date : 2021-05-26 Rosie J. Somerville
In the early 1980s, Shvo and co-workers reported a molecular ruthenium complex that was active in the catalytic dehydrogenation of alcohols and the hydrogenation of carbonyl compounds. Although the reactions themselves were already known, the ligand represented a new paradigm in bond formation/breaking processes that influences homogeneous catalysis to this day. The early 1980s witnessed the report
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In pursuit of universality Nat. Rev. Chem. (IF 34.035) Pub Date : 2021-05-25 Katarzyna Pernal, Michał Hapka
Finding the best approximation to the exact functional of electron density is the central challenge of density functional theory (DFT). In 2005, Zhao, Schultz and Truhlar paved the way to the development of approximate DFT functionals that can offer universally accurate treatment of different chemical systems and properties.
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Storybook science Nat. Rev. Chem. (IF 34.035) Pub Date : 2021-05-24 Rosalind N. Turner, Kristy L. Turner
Our review of Nano is the the joint work of Rosalind (9) and Kristy, her Mum.
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Dual-locked spectroscopic probes for sensing and therapy Nat. Rev. Chem. (IF 34.035) Pub Date : 2021-05-20 Luling Wu, Jiaguo Huang, Kanyi Pu, Tony D. James
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Do the twist Nat. Rev. Chem. (IF 34.035) Pub Date : 2021-05-20 Thomas West
Twisted nanoribbons with up to 322 atoms in the aromatic core (53 rings) have been prepared.
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Molecular excited states through a machine learning lens Nat. Rev. Chem. (IF 34.035) Pub Date : 2021-05-20 Pavlo O. Dral, Mario Barbatti
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Author Correction: Chemical targets to deactivate biological and chemical toxins using surfaces and fabrics Nat. Rev. Chem. (IF 34.035) Pub Date : 2021-05-17 Christia R. Jabbour, Luke A. Parker, Eline M. Hutter, Bert M. Weckhuysen
A Correction to this paper has been published: 10.1038/s41570-021-00292-3.
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A letter on rejection to my younger self Nat. Rev. Chem. (IF 34.035) Pub Date : 2021-05-07 Marc Reid
As scientists of all stripes grow as leaders, it becomes their responsibility to shed light on the opportunities that may be hidden within an apparent failure. Presented as a letter to his younger self, Marc Reid looks back at the time when he could scarcely handle professional rejection and examines the lessons he learned.
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Phosphine wins Au after double elimination Nat. Rev. Chem. (IF 34.035) Pub Date : 2021-05-07 David Schilter
Gold(III) complexes can undergo facile reductive elimination of aryl halides, particularly when bulky co-ligands are present. This study informs us about the elementary reactions of copper(III) congeners, which are prominent intermediates in organic cross-couplings.
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Chemical targets to deactivate biological and chemical toxins using surfaces and fabrics Nat. Rev. Chem. (IF 34.035) Pub Date : 2021-05-05 Christia R. Jabbour, Luke A. Parker, Eline M. Hutter, Bert M. Weckhuysen
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Experiments@home Nat. Rev. Chem. (IF 34.035) Pub Date : 2021-04-30 Vittorio Saggiomo, Aldrik H. Velders
The coronavirus pandemic forced a rapid adoption of online learning. What can be done for teaching the practical elements of subjects like chemistry? Have we learned anything that we would keep outside of lockdown restrictions?
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Reversible catalysis Nat. Rev. Chem. (IF 34.035) Pub Date : 2021-04-30 Vincent Fourmond, Nicolas Plumeré, Christophe Léger
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3D paintings Nat. Rev. Chem. (IF 34.035) Pub Date : 2021-04-20 Gabriella Graziano
Surface tension can help peel a 2D drawing away from the paper and convert it into a 3D object.
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Characterizing amorphous MOFs Nat. Rev. Chem. (IF 34.035) Pub Date : 2021-04-20 Claire Ashworth
A combined experimental and computational approach provides structural insight into amorphous metal–organic frameworks.
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Diversity provides the solution Nat. Rev. Chem. (IF 34.035) Pub Date : 2021-04-15 Stacey-Lynn Paiva
A diversity-oriented synthesis approach to prepare libraries of porous materials has enabled the identification of polymers with specific and tunable lithium-ion transport properties that may be applied in the production of more efficient batteries and fuel cells.
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Breaker of chains Nat. Rev. Chem. (IF 34.035) Pub Date : 2021-04-13 Kevin Davies
A review of Walter Isaacson’s book The Code Breaker, which takes us behind the scenes to reveal the personal stories of the chemists behind the CRISPR gene editing technology.
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Bifunctional reagents in organic synthesis Nat. Rev. Chem. (IF 34.035) Pub Date : 2021-04-12 Huan-Ming Huang, Peter Bellotti, Jiajia Ma, Toryn Dalton, Frank Glorius
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Interrogating biological systems using visible-light-powered catalysis Nat. Rev. Chem. (IF 34.035) Pub Date : 2021-03-29 Keun Ah Ryu, Christina M. Kaszuba, Noah B. Bissonnette, Rob C. Oslund, Olugbeminiyi O. Fadeyi
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Author Correction: Natural and synthetic carbohydrate-based vaccine adjuvants and their mechanisms of action Nat. Rev. Chem. (IF 34.035) Pub Date : 2021-03-26 Carlo Pifferi, Roberto Fuentes, Alberto Fernández-Tejada
A Correction to this paper has been published: https://doi.org/10.1038/s41570-021-00273-6.
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Modern cluster design based on experiment and theory Nat. Rev. Chem. (IF 34.035) Pub Date : 2021-03-24 Takamasa Tsukamoto, Tetsuya Kambe, Takane Imaoka, Kimihisa Yamamoto
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Publisher Correction: Organic reactivity from mechanism to machine learning Nat. Rev. Chem. (IF 34.035) Pub Date : 2021-03-22 Kjell Jorner, Anna Tomberg, Christoph Bauer, Christian Sköld, Per-Ola Norrby
A Correction to this paper has been published: https://doi.org/10.1038/s41570-021-00272-7.
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Sustainable implementation of innovative technologies for water purification Nat. Rev. Chem. (IF 34.035) Pub Date : 2021-03-22 Bart Van der Bruggen
One of the sustainable development goals set by the United Nations General Assembly is to ensure the availability and sustainable management of water and sanitation for all. This requires investment in water purification technologies. World Water Day offers an opportunity to discuss whether such investment will help achieve this laudable goal.
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Botanical bonanza Nat. Rev. Chem. (IF 34.035) Pub Date : 2021-03-17 Stephen G. Davey
(−)-Isoscopariusin A is the fourth natural product with potential immunosuppressive activity to be isolated from Isodon scoparius — a plant used in traditional Chinese medicine. Its synthesis will enable further study of its interesting biological activity.
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The reconfigurable shape of liquids Nat. Rev. Chem. (IF 34.035) Pub Date : 2021-03-17 Gabriella Graziano
Redox-responsive supramolecular nanoparticle surfactants can aid the preparation and control of all-liquid constructs.
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Organic reactivity from mechanism to machine learning Nat. Rev. Chem. (IF 34.035) Pub Date : 2021-03-16 Kjell Jorner, Anna Tomberg, Christoph Bauer, Christian Sköld, Per-Ola Norrby
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