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11 clinical trials that will shape medicine in 2024 Nat. Med. (IF 82.9) Pub Date : 2023-12-07 Carrie Arnold, Paul Webster
Nature Medicine asks leading researchers to name their top clinical trial for 2024, from base editing and a vaccine against HIV to artificial intelligence tools for lung cancer and patient triage.
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Multi-ancestry study of the genetics of problematic alcohol use in over 1 million individuals Nat. Med. (IF 82.9) Pub Date : 2023-12-07 Hang Zhou, Rachel L. Kember, Joseph D. Deak, Heng Xu, Sylvanus Toikumo, Kai Yuan, Penelope A. Lind, Leila Farajzadeh, Lu Wang, Alexander S. Hatoum, Jessica Johnson, Hyunjoon Lee, Travis T. Mallard, Jiayi Xu, Keira J. A. Johnston, Emma C. Johnson, Trine Tollerup Nielsen, Marco Galimberti, Cecilia Dao, Daniel F. Levey, Cassie Overstreet, Enda M. Byrne, Nathan A. Gillespie, Scott Gordon, Ian B. Hickie
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Divarasib plus cetuximab in KRAS G12C-positive colorectal cancer: a phase 1b trial Nat. Med. (IF 82.9) Pub Date : 2023-12-05 Jayesh Desai, Guzman Alonso, Se Hyun Kim, Andres Cervantes, Thomas Karasic, Laura Medina, Einat Shacham-Shmueli, Rasha Cosman, Alejandro Falcon, Eelke Gort, Tormod Guren, Erminia Massarelli, Wilson H. Miller, Luis Paz-Ares, Hans Prenen, Alessio Amatu, Chiara Cremolini, Tae Won Kim, Victor Moreno, Sai-Hong I. Ou, Alessandro Passardi, Adrian Sacher, Armando Santoro, Rafal Stec, Susanna Ulahannan, Kathryn
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First-line talazoparib with enzalutamide in HRR-deficient metastatic castration-resistant prostate cancer: the phase 3 TALAPRO-2 trial Nat. Med. (IF 82.9) Pub Date : 2023-12-04 Karim Fizazi, Arun A. Azad, Nobuaki Matsubara, Joan Carles, Andre P. Fay, Ugo De Giorgi, Jae Young Joung, Peter C. C. Fong, Eric Voog, Robert J. Jones, Neal D. Shore, Curtis Dunshee, Stefanie Zschäbitz, Jan Oldenburg, Dingwei Ye, Xun Lin, Cynthia G. Healy, Nicola Di Santo, A. Douglas Laird, Fabian Zohren, Neeraj Agarwal
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Durability of single-dose HPV vaccination in young Kenyan women: randomized controlled trial 3-year results Nat. Med. (IF 82.9) Pub Date : 2023-12-04 Ruanne V. Barnabas, Elizabeth R. Brown, Maricianah A. Onono, Elizabeth A. Bukusi, Betty Njoroge, Rachel L. Winer, Denise A. Galloway, Leeya F. Pinder, Deborah Donnell, Imelda N. Wakhungu, Charlene Biwott, Syovata Kimanthi, Kate B. Heller, Diane G. Kanjilal, Daniel Pacella, Susan Morrison, Elena A. Rechkina, Stephen L. Cherne, Torin T. Schaafsma, R. Scott McClelland, Connie Celum, Jared M. Baeten, Nelly
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Thalamic deep brain stimulation in traumatic brain injury: a phase 1, randomized feasibility study Nat. Med. (IF 82.9) Pub Date : 2023-12-04 Nicholas D. Schiff, Joseph T. Giacino, Christopher R. Butson, Eun Young Choi, Jonathan L. Baker, Kyle P. O’Sullivan, Andrew P. Janson, Michael Bergin, Helen M. Bronte-Stewart, Jason Chua, Laurel DeGeorge, Sureyya Dikmen, Adam Fogarty, Linda M. Gerber, Mark Krel, Jose Maldonado, Matthew Radovan, Sudhin A. Shah, Jason Su, Nancy Temkin, Thomas Tourdias, Jonathan D. Victor, Abigail Waters, Stephanie A
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Author Correction: Inhibition of Notch signaling ameliorates insulin resistance in a FoxO1-dependent manner Nat. Med. (IF 82.9) Pub Date : 2023-12-01 Utpal B. Pajvani, Carrie J. Shawber, Varman T. Samuel, Andreas L. Birkenfeld, Gerald I. Shulman, Jan Kitajewski, Domenico Accili
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Machine learning improves prediction of clinical outcomes for invasive breast cancers Nat. Med. (IF 82.9) Pub Date : 2023-11-30
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Six ways large language models are changing healthcare Nat. Med. (IF 82.9) Pub Date : 2023-11-30 Paul Webster
Nature Medicine asks six leading AI researchers to explain how LLM-powered chatbots are having an impact on health, from virtual nurses to detecting cancer progression.
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Semaglutide offers new route to cardiovascular risk reduction Nat. Med. (IF 82.9) Pub Date : 2023-11-30
In people with cardiovascular disease (without diabetes) and overweight or obesity, the GLP-1 receptor agonist semaglutide significantly reduced the risk of major cardiovascular events.
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Monitoring medical AI device adoption Nat. Med. (IF 82.9) Pub Date : 2023-11-28
The adoption of medical AI devices in clinical practice is still in its infancy, with uneven usage across procedures and locations in the USA, which underscores the inequities in its real-world implementation.
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CT scans in young people and risk of hematological malignancies Nat. Med. (IF 82.9) Pub Date : 2023-11-29
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A population-level digital histologic biomarker for enhanced prognosis of invasive breast cancer Nat. Med. (IF 82.9) Pub Date : 2023-11-27 Mohamed Amgad, James M. Hodge, Maha A. T. Elsebaie, Clara Bodelon, Samantha Puvanesarajah, David A. Gutman, Kalliopi P. Siziopikou, Jeffery A. Goldstein, Mia M. Gaudet, Lauren R. Teras, Lee A. D. Cooper
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Financial incentives for COVID-19 vaccines in a rural low-resource setting: a cluster-randomized trial Nat. Med. (IF 82.9) Pub Date : 2023-11-27 Raymond Duch, Edward Asiedu, Ryota Nakamura, Thomas Rouyard, Alberto Mayol, Adrian Barnett, Laurence Roope, Mara Violato, Dorcas Sowah, Piotr Kotlarz, Philip Clarke
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GLP-1 receptor agonists are promising but unproven treatments for alcohol and substance use disorders Nat. Med. (IF 82.9) Pub Date : 2023-11-24 Lorenzo Leggio, Christian S. Hendershot, Mehdi Farokhnia, Anders Fink-Jensen, Mette Kruse Klausen, Joseph P. Schacht, W. Kyle Simmons
Preclinical and initial human studies suggest that glucagon-like peptide-1 receptor agonists may be promising treatments for alcohol use disorder, but existing approved treatments should be used until safety and efficacy is demonstrated in clinical trials.
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Prevalence of chromosomal alterations in first-trimester spontaneous pregnancy loss Nat. Med. (IF 82.9) Pub Date : 2023-11-23 Rick Essers, Igor N. Lebedev, Ants Kurg, Elizaveta A. Fonova, Servi J. C. Stevens, Rebekka M. Koeck, Ulrike von Rango, Lloyd Brandts, Spyridon Panagiotis Deligiannis, Tatyana V. Nikitina, Elena A. Sazhenova, Ekaterina N. Tolmacheva, Anna A. Kashevarova, Dmitry A. Fedotov, Viktoria V. Demeneva, Daria I. Zhigalina, Gleb V. Drozdov, Salwan Al-Nasiry, Merryn V. E. Macville, Arthur van den Wijngaard, Jos
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Viral, cellular and immune aspects of non-suppressible HIV-1 viremia Nat. Med. (IF 82.9) Pub Date : 2023-11-23
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WHO sets research agenda for refugee and migrant health Nat. Med. (IF 82.9) Pub Date : 2023-11-23
The report — the first of its kind from the WHO — is intended as a roadmap for building responsive and inclusive health systems for displaced people.
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AI and imaging-based cancer screening: getting ready for prime time Nat. Med. (IF 82.9) Pub Date : 2023-11-20 Jörg Kleeff, Ulrich Ronellenfitsch
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Large-scale pancreatic cancer detection via non-contrast CT and deep learning Nat. Med. (IF 82.9) Pub Date : 2023-11-20 Kai Cao, Yingda Xia, Jiawen Yao, Xu Han, Lukas Lambert, Tingting Zhang, Wei Tang, Gang Jin, Hui Jiang, Xu Fang, Isabella Nogues, Xuezhou Li, Wenchao Guo, Yu Wang, Wei Fang, Mingyan Qiu, Yang Hou, Tomas Kovarnik, Michal Vocka, Yimei Lu, Yingli Chen, Xin Chen, Zaiyi Liu, Jian Zhou, Chuanmiao Xie, Rong Zhang, Hong Lu, Gregory D. Hager, Alan L. Yuille, Le Lu, Chengwei Shao, Yu Shi, Qi Zhang, Tingbo Liang
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The type II RAF inhibitor tovorafenib in relapsed/refractory pediatric low-grade glioma: the phase 2 FIREFLY-1 trial Nat. Med. (IF 82.9) Pub Date : 2023-11-17 Lindsay B. Kilburn, Dong-Anh Khuong-Quang, Jordan R. Hansford, Daniel Landi, Jasper van der Lugt, Sarah E. S. Leary, Pablo Hernáiz Driever, Simon Bailey, Sébastien Perreault, Geoffrey McCowage, Angela J. Waanders, David S. Ziegler, Olaf Witt, Patricia A. Baxter, Hyoung Jin Kang, Timothy E. Hassall, Jung Woo Han, Darren Hargrave, Andrea T. Franson, Michal Yalon Oren, Helen Toledano, Valérie Larouche
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Wireless broadband acousto-mechanical sensing system for continuous physiological monitoring Nat. Med. (IF 82.9) Pub Date : 2023-11-16 Jae-Young Yoo, Seyong Oh, Wissam Shalish, Woo-Youl Maeng, Emily Cerier, Emily Jeanne, Myung-Kun Chung, Shasha Lv, Yunyun Wu, Seonggwang Yoo, Andreas Tzavelis, Jacob Trueb, Minsu Park, Hyoyoung Jeong, Efe Okunzuwa, Slobodanka Smilkova, Gyeongwu Kim, Junha Kim, Gooyoon Chung, Yoonseok Park, Anthony Banks, Shuai Xu, Guilherme M. Sant’Anna, Debra E. Weese-Mayer, Ankit Bharat, John A. Rogers
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Striving for equitable partnerships in health research Nat. Med. (IF 82.9) Pub Date : 2023-11-16
A year ago, we adopted an ethics framework to help with the assessment of and to increase transparency and accountability for research practices in studies involving partnerships between researchers in high- and low-income settings. We now reflect on our progress, what we learned and the way forward to champion ethical, inclusive and equitable partnerships in the content we publish.
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Linking the vaginal microbiome to women’s health Nat. Med. (IF 82.9) Pub Date : 2023-11-16
A citizen science approach has helped craft a resource-rich vaginal microbiome map with associations to lifestyle and events across a woman’s life course.
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Clonal selection of hematopoietic stem cells after gene therapy for sickle cell disease Nat. Med. (IF 82.9) Pub Date : 2023-11-16 Michael Spencer Chapman, Alyssa H. Cull, Marioara F. Ciuculescu, Erica B. Esrick, Emily Mitchell, Hyunchul Jung, Laura O’Neill, Kirsty Roberts, Margarete A. Fabre, Nicholas Williams, Jyoti Nangalia, Joanne Quinton, James M. Fox, Danilo Pellin, Julie Makani, Myriam Armant, David A. Williams, Peter J. Campbell, David G. Kent
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Prospective implementation of AI-assisted screen reading to improve early detection of breast cancer Nat. Med. (IF 82.9) Pub Date : 2023-11-16 Annie Y. Ng, Cary J. G. Oberije, Éva Ambrózay, Endre Szabó, Orsolya Serfőző, Edit Karpati, Georgia Fox, Ben Glocker, Elizabeth A. Morris, Gábor Forrai, Peter D. Kecskemethy
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Viral and host mediators of non-suppressible HIV-1 viremia Nat. Med. (IF 82.9) Pub Date : 2023-11-13 Abbas Mohammadi, Behzad Etemad, Xin Zhang, Yijia Li, Gregory J. Bedwell, Radwa Sharaf, Autumn Kittilson, Meghan Melberg, Charles R. Crain, Anna K. Traunbauer, Colline Wong, Jesse Fajnzylber, Daniel P. Worrall, Alex Rosenthal, Hannah Jordan, Nikolaus Jilg, Clarety Kaseke, Francoise Giguel, Xiaodong Lian, Rinki Deo, Elisabeth Gillespie, Rida Chishti, Sara Abrha, Taylor Adams, Abigail Siagian, Dominic
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Five award-winning researchers share their tips for inclusive health research Nat. Med. (IF 82.9) Pub Date : 2023-11-15 Ben Johnson
We asked the winners of the Nature Award for Inclusive Health Research to share their key lessons for conducting medical research in partnership with under-represented communities.
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Determining the longevity and dynamics of HIV-1 neutralizing activity Nat. Med. (IF 82.9) Pub Date : 2023-11-13
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Association between pretreatment emotional distress and neoadjuvant immune checkpoint blockade response in melanoma Nat. Med. (IF 82.9) Pub Date : 2023-11-13 Itske Fraterman, Irene L. M. Reijers, Petros Dimitriadis, Annegien Broeks, M. Gonzalez, A. M. M. Menzies, Marta Lopez-Yurda, Ellen Kapiteijn, Astrid A. M. van der Veldt, Karijn P. M. Suijkerbuijk, Geke A. P. Hospers, Georgina V. Long, Christian U. Blank, Lonneke V. van de Poll-Franse
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PROTACs reach clinical development in inflammatory skin disease Nat. Med. (IF 82.9) Pub Date : 2023-11-13 Fleur M. Ferguson
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Person-centered HIV PrEP for cisgender women Nat. Med. (IF 82.9) Pub Date : 2023-11-13 Maryam Shahmanesh, Natsayi Chimbindi, Frances M. Cowan
Two modelling studies offer compelling evidence that less-than-perfect adherence to HIV pre-exposure prophylaxis can still provide reasonable protection for cisgender women — providing optimism for a more person-centered approach and lower discontinuation rates.
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Reporting standards for the use of large language model-linked chatbots for health advice Nat. Med. (IF 82.9) Pub Date : 2023-11-13 Bright Huo, Giovanni E. Cacciamani, Gary S. Collins, Tyler McKechnie, Yung Lee, Gordon Guyatt
Modern artificial intelligence (AI)-based chatbots such as ChatGPT leverage the technology of large language models (LLMs) and natural language processing1. These chatbots use natural language processing to enable user interactions via a chat-based interface that produces LLM-generated text. Their performance has improved as LLM-linked chatbots are increasingly being trained with online sources, and
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A new, affordable HPV vaccine Nat. Med. (IF 82.9) Pub Date : 2023-11-13
A quadrivalent vaccine against human papillomavirus produced by the Serum Institute of India was shown to be noninferior to the established quadrivalent vaccine — boosting global efforts to eliminate cervical cancer.
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Robust airway microbiome signatures in acute respiratory failure and hospital-acquired pneumonia Nat. Med. (IF 82.9) Pub Date : 2023-11-13 Emmanuel Montassier, Georgios D. Kitsios, Josiah E. Radder, Quentin Le Bastard, Brendan J. Kelly, Ariane Panzer, Susan V. Lynch, Carolyn S. Calfee, Robert P. Dickson, Antoine Roquilly
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Model-based predictions of protective HIV pre-exposure prophylaxis adherence levels in cisgender women Nat. Med. (IF 82.9) Pub Date : 2023-11-13 Lanxin Zhang, Sara Iannuzzi, Ayyappa Chaturvedula, Elizabeth Irungu, Jessica E. Haberer, Craig W. Hendrix, Max von Kleist
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Dynamics and durability of HIV-1 neutralization are determined by viral replication Nat. Med. (IF 82.9) Pub Date : 2023-11-13 Philipp Schommers, Dae Sung Kim, Maike Schlotz, Christoph Kreer, Ralf Eggeling, Anna Hake, Melanie Stecher, Juyeon Park, Caelan E. Radford, Adam S. Dingens, Meryem S. Ercanoglu, Henning Gruell, Stanley Odidika, Marten Dahlhaus, Lutz Gieselmann, Elvin Ahmadov, Rene Y. Lawong, Eva Heger, Elena Knops, Christoph Wyen, Tim Kümmerle, Katja Römer, Stefan Scholten, Timo Wolf, Christoph Stephan, Isabelle Suárez
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IRAK4 degrader in hidradenitis suppurativa and atopic dermatitis: a phase 1 trial Nat. Med. (IF 82.9) Pub Date : 2023-11-13 Lindsay Ackerman, Gerard Acloque, Sandro Bacchelli, Howard Schwartz, Brian J. Feinstein, Phillip La Stella, Afsaneh Alavi, Ashwin Gollerkeri, Jeffrey Davis, Veronica Campbell, Alice McDonald, Sagar Agarwal, Rahul Karnik, Kelvin Shi, Aimee Mishkin, Jennifer Culbertson, Christine Klaus, Bradley Enerson, Virginia Massa, Eric Kuhn, Kirti Sharma, Erin Keaney, Randy Barnes, Dapeng Chen, Xiaozhang Zheng,
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Targeted gene expression profiling predicts meningioma outcomes and radiotherapy responses Nat. Med. (IF 82.9) Pub Date : 2023-11-09 William C. Chen, Abrar Choudhury, Mark W. Youngblood, Mei-Yin C. Polley, Calixto-Hope G. Lucas, Kanish Mirchia, Sybren L. N. Maas, Abigail K. Suwala, Minhee Won, James C. Bayley, Akdes S. Harmanci, Arif Harmanci, Tiemo J. Klisch, Minh P. Nguyen, Harish N. Vasudevan, Kathleen McCortney, Theresa J. Yu, Varun Bhave, Tai-Chung Lam, Jenny Kan-Suen Pu, Lai-Fung Li, Gilberto Ka-Kit Leung, Jason W. Chan, Haley
Surgery is the mainstay of treatment for meningioma, the most common primary intracranial tumor, but improvements in meningioma risk stratification are needed and indications for postoperative radiotherapy are controversial. Here we develop a targeted gene expression biomarker that predicts meningioma outcomes and radiotherapy responses. Using a discovery cohort of 173 meningiomas, we developed a 34-gene
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Global variation in diabetes diagnosis and prevalence based on fasting glucose and hemoglobin A1c Nat. Med. (IF 82.9) Pub Date : 2023-11-09
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Risk of hematological malignancies from CT radiation exposure in children, adolescents and young adults Nat. Med. (IF 82.9) Pub Date : 2023-11-09 Magda Bosch de Basea Gomez, Isabelle Thierry-Chef, Richard Harbron, Michael Hauptmann, Graham Byrnes, Maria-Odile Bernier, Lucian Le Cornet, Jérémie Dabin, Gilles Ferro, Tore S. Istad, Andreas Jahnen, Choonsik Lee, Carlo Maccia, Françoise Malchair, Hilde Olerud, Steven L. Simon, Jordi Figuerola, Anna Peiro, Hilde Engels, Christoffer Johansen, Maria Blettner, Magnus Kaijser, Kristina Kjaerheim, Amy
Over one million European children undergo computed tomography (CT) scans annually. Although moderate- to high-dose ionizing radiation exposure is an established risk factor for hematological malignancies, risks at CT examination dose levels remain uncertain. Here we followed up a multinational cohort (EPI-CT) of 948,174 individuals who underwent CT examinations before age 22 years in nine European
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Coproducing health research with Indigenous peoples Nat. Med. (IF 82.9) Pub Date : 2023-11-09 Chris Cunningham, Monica Mercury
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Spinal stimulation for unfreezing gait in Parkinson’s disease Nat. Med. (IF 82.9) Pub Date : 2023-11-06 Aviv Mizrahi-Kliger, Karunesh Ganguly
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Boosting CAR T cells with anti-tumor mRNA vaccines Nat. Med. (IF 82.9) Pub Date : 2023-11-06 Alex Chehrazi-Raffle, Lihua E. Budde, Sumanta K. Pal
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A spinal cord neuroprosthesis for locomotor deficits due to Parkinson’s disease Nat. Med. (IF 82.9) Pub Date : 2023-11-06 Tomislav Milekovic, Eduardo Martin Moraud, Nicolo Macellari, Charlotte Moerman, Flavio Raschellà, Shiqi Sun, Matthew G. Perich, Camille Varescon, Robin Demesmaeker, Alice Bruel, Léa N. Bole-Feysot, Giuseppe Schiavone, Elvira Pirondini, Cheng YunLong, Li Hao, Andrea Galvez, Sergio Daniel Hernandez-Charpak, Gregory Dumont, Jimmy Ravier, Camille G. Le Goff-Mignardot, Jean-Baptiste Mignardot, Gaia Carparelli
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Bacterial SNPs in the human gut microbiome associate with host BMI Nat. Med. (IF 82.9) Pub Date : 2023-11-02 Liron Zahavi, Amit Lavon, Lee Reicher, Saar Shoer, Anastasia Godneva, Sigal Leviatan, Michal Rein, Omer Weissbrod, Adina Weinberger, Eran Segal
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Cell-based versus corticosteroid injections for knee pain in osteoarthritis: a randomized phase 3 trial Nat. Med. (IF 82.9) Pub Date : 2023-11-02 Ken Mautner, Michael Gottschalk, Scott D. Boden, Alison Akard, Won C. Bae, Lora Black, Blake Boggess, Paramita Chatterjee, Christine B. Chung, Kirk A. Easley, Greg Gibson, Josh Hackel, Katie Jensen, Linda Kippner, Chad Kurtenbach, Joanne Kurtzberg, R. Amadeus Mason, Benjamin Noonan, Krishnendu Roy, Verle Valentine, Carolyn Yeago, Hicham Drissi
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Nirmatrelvir/ritonavir use in pregnant women with SARS-CoV-2 Omicron infection: a target trial emulation Nat. Med. (IF 82.9) Pub Date : 2023-11-01 Carlos K. H. Wong, Kristy T. K. Lau, Matthew S. H. Chung, Ivan C. H. Au, Ka Wang Cheung, Eric H. Y. Lau, Yasmin Daoud, Benjamin J. Cowling, Gabriel M. Leung
To date there is a lack of randomized trial data examining the use of the antiviral nirmatrelvir/ritonavir in SARS-CoV-2-infected pregnant persons. This target trial emulation study aims to address this gap by evaluating the use of nirmatrelvir/ritonavir in non-hospitalized pregnant women with symptomatic SARS-CoV-2 Omicron variant infection. Among patients diagnosed between 16th March 2022 and 5th
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AI aids brain tumor surgery Nat. Med. (IF 82.9) Pub Date : 2023-10-31
A machine-learning diagnosis tool, based on low-cost sequencing, can assist decision-making during brain surgeries.
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Association between pathologic response and survival after neoadjuvant therapy in lung cancer Nat. Med. (IF 82.9) Pub Date : 2023-10-30 Julie Stein Deutsch, Ashley Cimino-Mathews, Elizabeth Thompson, Mariano Provencio, Patrick M. Forde, Jonathan Spicer, Nicolas Girard, Daphne Wang, Robert A. Anders, Edward Gabrielson, Peter Illei, Jaroslaw Jedrych, Ludmila Danilova, Joel Sunshine, Keith M. Kerr, Mia Tran, Judy Bushong, Junliang Cai, Vipul Devas, Jaclyn Neely, David Balli, Tricia R. Cottrell, Alex S. Baras, Janis M. Taube
Neoadjuvant immunotherapy plus chemotherapy improves event-free survival (EFS) and pathologic complete response (pCR, 0% residual viable tumor [RVT] in primary tumor [PT]+lymph nodes [LNs]), and is approved for treatment of resectable lung cancer. Pathologic response assessment after neoadjuvant therapy is the potential analog to radiographic response for advanced disease. However, %RVT thresholds
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A little knowledge can be a dangerous thing Nat. Med. (IF 82.9) Pub Date : 2023-10-30
A study has found that people with intermediate levels of scientific knowledge have the highest levels of overconfidence — and the most negative attitudes toward science.
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An integrated gene-to-outcome multimodal database for metabolic dysfunction-associated steatotic liver disease Nat. Med. (IF 82.9) Pub Date : 2023-10-30 Timothy J. Kendall, Maria Jimenez-Ramos, Frances Turner, Prakash Ramachandran, Jessica Minnier, Michael D. McColgan, Masood Alam, Harriet Ellis, Donald R. Dunbar, Gabriele Kohnen, Prakash Konanahalli, Karin A. Oien, Lucia Bandiera, Filippo Menolascina, Anna Juncker-Jensen, Douglas Alexander, Charlie Mayor, Indra Neil Guha, Jonathan A. Fallowfield
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Evidence for a role of Anopheles stephensi in the spread of drug and diagnosis-resistant malaria in Africa Nat. Med. (IF 82.9) Pub Date : 2023-10-26 Tadele Emiru, Dejene Getachew, Maxwell Murphy, Luigi Sedda, Legesse Alamerie Ejigu, Mikiyas Gebremichael Bulto, Isabel Byrne, Mulugeta Demisse, Melat Abdo, Wakweya Chali, Aaron Elliott, Eric Neubauer Vickers, Andrés Aranda-Díaz, Lina Alemayehu, Sinknesh W. Behaksera, Gutema Jebessa, Hunduma Dinka, Tizita Tsegaye, Hiwot Teka, Sheleme Chibsa, Peter Mumba, Samuel Girma, Jimee Hwang, Melissa Yoshimizu
Anopheles stephensi, an Asian malaria vector, continues to expand across Africa. The vector is now firmly established in urban settings in the Horn of Africa. Its presence in areas where malaria resurged suggested a possible role in causing malaria outbreaks. Using a prospective case control design, we investigated the role of An. stephensi in transmission following a malaria outbreak in Dire Dawa
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The value of standards for health datasets in artificial intelligence-based applications Nat. Med. (IF 82.9) Pub Date : 2023-10-26 Anmol Arora, Joseph E. Alderman, Joanne Palmer, Shaswath Ganapathi, Elinor Laws, Melissa D. McCradden, Lauren Oakden-Rayner, Stephen R. Pfohl, Marzyeh Ghassemi, Francis McKay, Darren Treanor, Negar Rostamzadeh, Bilal Mateen, Jacqui Gath, Adewole O. Adebajo, Stephanie Kuku, Rubeta Matin, Katherine Heller, Elizabeth Sapey, Neil J. Sebire, Heather Cole-Lewis, Melanie Calvert, Alastair Denniston, Xiaoxuan
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Underrepresentation of blind and deaf participants in the All of Us Research Program Nat. Med. (IF 82.9) Pub Date : 2023-10-26 Colby Lewis V, Jack Huebner, George Hripcsak, Maya Sabatello
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Thymus alterations and susceptibility to immune checkpoint inhibitor myocarditis Nat. Med. (IF 82.9) Pub Date : 2023-10-26 Charlotte Fenioux, Baptiste Abbar, Samia Boussouar, Marie Bretagne, John R. Power, Javid J. Moslehi, Paul Gougis, Damien Amelin, Agnès Dechartres, Lorenz H. Lehmann, Pierre-Yves Courand, Jennifer Cautela, Joachim Alexandre, Adrien Procureur, Antoine Rozes, Sarah Leonard-Louis, Juan Qin, Rémi Cheynier, Benedicte Charmeteau-De Muylder, Alban Redheuil, Florence Tubach, Jacques Cadranel, Audrey Milon,
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CLDN6-specific CAR-T cells plus amplifying RNA vaccine in relapsed or refractory solid tumors: the phase 1 BNT211-01 trial Nat. Med. (IF 82.9) Pub Date : 2023-10-23 Andreas Mackensen, John B.A.G. Haanen, Christian Koenecke, Winfried Alsdorf, Eva Wagner-Drouet, Peter Borchmann, Daniel Heudobler, Barbara Ferstl, Sebastian Klobuch, Carsten Bokemeyer, Alexander Desuki, Florian Lüke, Nadine Kutsch, Fabian Müller, Eveline Smit, Peter Hillemanns, Panagiotis Karagiannis, Erol Wiegert, Ying He, Thang Ho, Qing Kang-Fortner, Anna Melissa Schlitter, Catrine Schulz-Eying,
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Mapping the cellular landscape of the brain Nat. Med. (IF 82.9) Pub Date : 2023-10-24
Using an array of multi-omic and other technologies, scientists have comprehensively mapped the types and specialties of brain cells — revealing insights into human evolution, development and disease.
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A rapid whole-genome sequencing service for infants with rare diseases in the United Arab Emirates Nat. Med. (IF 82.9) Pub Date : 2023-10-23 Ahmad N. Abou Tayoun, Alawi Alsheikh-Ali
A large body of evidence now supports use of rapid whole-genome sequencing (rWGS) as a cost-effective tool for timely diagnosis and tailored management of critically ill children with rare diseases. However, efficacy has so far been demonstrated only in high-income settings, which has led to disparate implementation of and variable access to rWGS.