Analysis of data related to the Ukraine famine of 1932–1933 shows that in utero exposure to famine increases the risk of adult type 2 diabetes by more than twofold.

arising from M. Ferrell et al. Nature Medicine https://doi.org/10.1038/s41591-023-02793-8 (2024) Ferrell et al.1 recently reported associations between serum levels of the terminal niacin metabolites N1-methyl-2-pyridone-5-carboxamide (2PY) and N1-methyl-4-pyridone-3-carboxamide (4PY) with an increased 3-year incident risk of major adverse cardiovascular events. The association of 4PY with cardiovascular

replying to J. R. Guyton & W. E. Boden Nature Medicine https://doi.org/10.1038/s41591-024-03220-2 (2024) replying to S. Schreiber et al. Nature Medicine https://doi.org/10.1038/s41591-024-03219-9 (2024)

Diversity, equity and inclusion (DEI) has become a political lightning rod in the USA, with its laudable mission increasingly misinterpreted as a blunt discriminatory tool. Although such critique has been ongoing for decades, it has intensified in academic medicine in recent months, from the resignation of Johns Hopkins’ chief diversity officer over an email on privilege, to efforts within the American

arising from M. Ferrell et al. Nature Medicine https://doi.org/10.1038/s41591-023-02793-8 (2024) Ferrell et al.1 report a surprisingly strong association between terminal metabolites of niacin and major adverse cardiovascular events (MACE), amounting to roughly a doubling of MACE risk in the 4th quartile of circulating levels of the 4PY (N1-methyl-4-pyridone-3-carboxamide) metabolite. The results presented

Multimorbidity, the cooccurrence of two or more chronic health conditions within the same individual, is increasingly prevalent worldwide and is associated with decreased health-related quality of life, increased mortality, and greater healthcare utilization1,2. The clinical care of multimorbidity is complex, arising from potential interactions between conditions, treatment regimens and overlapping

Point-of-care manufacturing and technology transfer can deliver cellular gene therapies at an affordable cost to patients across the world.

The publication of the first draft of the human genome sequence in 20011 was followed by the advent of high-throughput methodologies, which together have driven the expansion of genomic tools and technologies. These efforts have enabled the sequencing of millions of genomes and expedited the functional and clinical annotation of the human genome. The resulting discovery of thousands of gene–disease

HIV cure has been reported for five individuals who received allogeneic hematopoietic stem cell transplant (allo-HSCT) from CCR5Δ32 homozygous donors. In contrast, viral rebound has occurred in other people living with HIV who interrupted antiretroviral treatment after receiving allo-HSCT, mostly from wild-type CCR5 donors. Here, we report the case of a male who has achieved durable HIV remission following

Senolytics can prevent and treat age-related diseases in mice, but data in humans are lacking — for now.

Cardiovascular-kidney-metabolic syndrome is an emerging entity that connects cardiovascular diseases, chronic kidney disease, and diabetes. The non-steroidal mineralocorticoid receptor antagonist, finerenone, has been studied in three prospective randomized clinical trials of patients with cardio-kidney-metabolic syndrome: FIDELIO-DKD, FIGARO-DKD, and FINEARTS-HF. In light of the strong epidemiological

A large causal analysis based on a natural experiment suggests that gaming improves psychological well-being, but these benefits tapered off after more than 3 hours of gaming per day.

India is actively promoting a digital health ecosystem to support its quest for universal healthcare. Quality-graded health data can provide exceptional decision-making support in this endeavor. The biggest hurdle to developing artificial intelligence (AI)-enabled healthcare technologies in India is the availability of high-quality annotated data for South Asians, especially Indians, that can be used

Researchers developed an AI-enabled, battery-operated tool that can be operated by clinicians with no sonography experience — and that measures gestational age as accurately as high-specification ultrasound.

In a digital-only study, people were more likely to take a home test if prompted to do so on the basis of self-reported symptoms rather than by wearable sensor data, with implications for public health responses and pandemic planning.

Despite constituting 70% of the overall global health workforce, women hold only 25% of health leadership roles1. With progress towards equality2 projected to be painfully slow, the health sector must urgently address the systemic factors that hold women back. The world increasingly relies on the expertise of global health leaders to tackle challenges that transcend borders and sectors. However, health

Following the approval by the World Health Organization (WHO) of two new vaccines, RTS,S/AS01 and R21/Matrix-M, for malaria prevention in children, they are being administered in 12 malaria-endemic African countries, prioritizing areas with moderate to high transmission. These vaccines will be a game changer in the efforts to attain global elimination of malaria in the 35 or more malaria-endemic countries

Africa CDC has declared its first Public Health Emergency of Continental Security.

Genomics-based newborn screening has the potential to revolutionize healthcare, but new solutions are needed to ensure that the benefits are equitably available.

Risankizumab outperformed ustekinumab for the treatment of moderate to severe Crohn’s disease in patients refractory to anti-TNF therapy.

Transforming the fragmented silos of medicine into a wheel of collaboration holds the key to tackling complex health challenges for generations to come.