-
Climate change cranks up infectious disease impact Nat. Med. (IF 87.241) Pub Date : 2022-08-15
Over half of all infectious diseases that affect humans worldwide can be aggravated by climate change, which highlights the urgency of tough climate action and mitigation measures.
-
Retrospective detection of asymptomatic monkeypox virus infections among male sexual health clinic attendees in Belgium Nat. Med. (IF 87.241) Pub Date : 2022-08-12 Irith De Baetselier, Christophe Van Dijck, Chris Kenyon, Jasmine Coppens, Johan Michiels, Tessa de Block, Hilde Smet, Sandra Coppens, Fien Vanroye, Joachim Jakob Bugert, Philipp Girl, Sabine Zange, Laurens Liesenborghs, Isabel Brosius, Johan van Griensven, Philippe Selhorst, Eric Florence, Dorien Van den Bossche, Kevin K. Ariën, Antonio Mauro Rezende, Koen Vercauteren, Marjan Van Esbroeck
The magnitude of the 2022 multi-country monkeypox virus outbreak has surpassed any preceding outbreak. It is unclear whether asymptomatic or otherwise undiagnosed infections are fuelling this epidemic. We aimed to assess whether undiagnosed infections occurred among men attending a Belgian sexual health clinic in May 2022. We retrospectively screened 224 samples collected for gonorrhoea and chlamydia
-
Long COVID includes breathing and reproductive problems and has a range of risk factors Nat. Med. (IF 87.241) Pub Date : 2022-08-12
-
Pan-cancer efficacy of pralsetinib in patients with RET fusion–positive solid tumors from the phase 1/2 ARROW trial Nat. Med. (IF 87.241) Pub Date : 2022-08-12 Vivek Subbiah, Philippe A. Cassier, Salvatore Siena, Elena Garralda, Luis Paz-Ares, Pilar Garrido, Ernest Nadal, Jacqueline Vuky, Gilberto Lopes, Gregory P. Kalemkerian, Daniel W. Bowles, Mahesh Seetharam, Jianhua Chang, Hui Zhang, Jennifer Green, Alena Zalutskaya, Martin Schuler, Yun Fan, Giuseppe Curigliano
-
The clonal evolution of Richter transformation cells uncovers therapeutic vulnerabilities Nat. Med. (IF 87.241) Pub Date : 2022-08-11
-
A lightspeed approach to pandemic drug development Nat. Med. (IF 87.241) Pub Date : 2022-08-11 Annaliesa S. Anderson
Pfizer had successes during COVID-19 by streamlining decisions and running several steps in parallel, a lightspeed approach that can be applied to other diseases.
-
Cellular senescence and senolytics: the path to the clinic Nat. Med. (IF 87.241) Pub Date : 2022-08-11 Selim Chaib, Tamar Tchkonia, James L. Kirkland
-
Lipid lowering effects of the CETP inhibitor obicetrapib in combination with high-intensity statins: a randomized phase 2 trial Nat. Med. (IF 87.241) Pub Date : 2022-08-11 Stephen J. Nicholls, Marc Ditmarsch, John J. Kastelein, Scott P. Rigby, Douglas Kling, Danielle L. Curcio, Nicholas John Alp, Michael H. Davidson
-
Detection of early seeding of Richter transformation in chronic lymphocytic leukemia Nat. Med. (IF 87.241) Pub Date : 2022-08-11 Ferran Nadeu, Romina Royo, Ramon Massoni-Badosa, Heribert Playa-Albinyana, Beatriz Garcia-Torre, Martí Duran-Ferrer, Kevin J. Dawson, Marta Kulis, Ander Diaz-Navarro, Neus Villamor, Juan L. Melero, Vicente Chapaprieta, Ana Dueso-Barroso, Julio Delgado, Riccardo Moia, Sara Ruiz-Gil, Domenica Marchese, Ariadna Giró, Núria Verdaguer-Dot, Mónica Romo, Guillem Clot, Maria Rozman, Gerard Frigola, Alfredo
-
Plasma p-tau231 and p-tau217 as state markers of amyloid-β pathology in preclinical Alzheimer’s disease Nat. Med. (IF 87.241) Pub Date : 2022-08-11 Marta Milà-Alomà, Nicholas J. Ashton, Mahnaz Shekari, Gemma Salvadó, Paula Ortiz-Romero, Laia Montoliu-Gaya, Andrea L. Benedet, Thomas K. Karikari, Juan Lantero-Rodriguez, Eugeen Vanmechelen, Theresa A. Day, Armand González-Escalante, Gonzalo Sánchez-Benavides, Carolina Minguillon, Karine Fauria, José Luis Molinuevo, Jeffrey L. Dage, Henrik Zetterberg, Juan Domingo Gispert, Marc Suárez-Calvet, Kaj
-
A wearable ultrasound patch Nat. Med. (IF 87.241) Pub Date : 2022-08-11
Ultrasounds can provide a wealth of information on organ function and disease; now scientists have engineered a stick-on wearable ultrasound device for continuous monitoring.
-
Identification of genetic correlates of coronary artery disease in diverse ancestral populations Nat. Med. (IF 87.241) Pub Date : 2022-08-10
-
Make deep learning algorithms in computational pathology more reproducible and reusable Nat. Med. (IF 87.241) Pub Date : 2022-08-08 Sophia J. Wagner, Christian Matek, Sayedali Shetab Boushehri, Melanie Boxberg, Lorenz Lamm, Ario Sadafi, Dominik J. E. Waibel, Carsten Marr, Tingying Peng
-
Predicting chronic morbidity in childhood cancer survivors Nat. Med. (IF 87.241) Pub Date : 2022-08-08 Lynda M. Vrooman, Lisa R. Diller
-
Next steps for the xenotransplantation of pig organs into humans Nat. Med. (IF 87.241) Pub Date : 2022-08-08 Robert A. Montgomery, Sapna A. Mehta, Brendan Parent, Adam Griesemer
Pigs offer a potentially plentiful supply of organs for humans, but widespread xenotransplantation will require a collaborative and iterative approach to research, as well as involvement of transplant patients and the public.
-
Trastuzumab deruxtecan in HER2-positive breast cancer with brain metastases: a single-arm, phase 2 trial Nat. Med. (IF 87.241) Pub Date : 2022-08-08 Rupert Bartsch, Anna Sophie Berghoff, Julia Furtner, Maximilian Marhold, Elisabeth Sophie Bergen, Sophie Roider-Schur, Angelika Martina Starzer, Heidrun Forstner, Beate Rottenmanner, Karin Dieckmann, Zsuzsanna Bago-Horvath, Helmuth Haslacher, Georg Widhalm, Aysegül Ilhan-Mutlu, Christoph Minichsdorfer, Thorsten Fuereder, Thomas Szekeres, Leopold Oehler, Birgit Gruenberger, Christian F. Singer, Ansgar
-
Pepinemab antibody blockade of SEMA4D in early Huntington’s disease: a randomized, placebo-controlled, phase 2 trial Nat. Med. (IF 87.241) Pub Date : 2022-08-08 Andrew Feigin, Elizabeth E. Evans, Terrence L. Fisher, John E. Leonard, Ernest S. Smith, Alisha Reader, Vikas Mishra, Richard Manber, Kimberly A. Walters, Lisa Kowarski, David Oakes, Eric Siemers, Karl D. Kieburtz, Maurice Zauderer
-
Author Correction: Increased circulation time of Plasmodium falciparum underlies persistent asymptomatic infection in the dry season Nat. Med. (IF 87.241) Pub Date : 2022-08-04 Carolina M. Andrade, Hannah Fleckenstein, Richard Thomson-Luque, Safiatou Doumbo, Nathalia F. Lima, Carrie Anderson, Julia Hibbert, Christine S. Hopp, Tuan M. Tran, Shanping Li, Moussa Niangaly, Hamidou Cisse, Didier Doumtabe, Jeff Skinner, Dan Sturdevant, Stacy Ricklefs, Kimmo Virtaneva, Muhammad Asghar, Manijeh Vafa Homann, Louise Turner, Joana Martins, Erik L. Allman, Marie-Esther N’Dri, Volker
-
Anti-inflammatory clearance of amyloid-β by a chimeric Gas6 fusion protein Nat. Med. (IF 87.241) Pub Date : 2022-08-04 Hyuncheol Jung, Se Young Lee, Seongjoon Lim, Hyeong Ryeol Choi, Yeseong Choi, Minjin Kim, Segi Kim, Yujean Lee, Kyung Ho Han, Won-Suk Chung, Chan Hyuk Kim
-
CRISPR–Cas9-mediated gene editing of the BCL11A enhancer for pediatric β0/β0 transfusion-dependent β-thalassemia Nat. Med. (IF 87.241) Pub Date : 2022-08-04 Bin Fu, Jiaoyang Liao, Shuanghong Chen, Wei Li, Qiudao Wang, Jian Hu, Fei Yang, Shenlin Hsiao, Yanhong Jiang, Liren Wang, Fangping Chen, Yuanjin Zhang, Xin Wang, Dali Li, Mingyao Liu, Yuxuan Wu
-
Circulating tumor DNA to guide rechallenge with panitumumab in metastatic colorectal cancer: the phase 2 CHRONOS trial Nat. Med. (IF 87.241) Pub Date : 2022-08-01 Andrea Sartore-Bianchi, Filippo Pietrantonio, Sara Lonardi, Benedetta Mussolin, Francesco Rua, Giovanni Crisafulli, Alice Bartolini, Elisabetta Fenocchio, Alessio Amatu, Paolo Manca, Francesca Bergamo, Federica Tosi, Gianluca Mauri, Margherita Ambrosini, Francesca Daniel, Valter Torri, Angelo Vanzulli, Daniele Regge, Giovanni Cappello, Caterina Marchiò, Enrico Berrino, Anna Sapino, Silvia Marsoni,
-
Large-scale genome-wide association study of coronary artery disease in genetically diverse populations Nat. Med. (IF 87.241) Pub Date : 2022-08-01 Catherine Tcheandjieu, Xiang Zhu, Austin T. Hilliard, Shoa L. Clarke, Valerio Napolioni, Shining Ma, Kyung Min Lee, Huaying Fang, Fei Chen, Yingchang Lu, Noah L. Tsao, Sridharan Raghavan, Satoshi Koyama, Bryan R. Gorman, Marijana Vujkovic, Derek Klarin, Michael G. Levin, Nasa Sinnott-Armstrong, Genevieve L. Wojcik, Mary E. Plomondon, Thomas M. Maddox, Stephen W. Waldo, Alexander G. Bick, Saiju Pyarajan
-
Easing the pain of endometriosis Nat. Med. (IF 87.241) Pub Date : 2022-07-28
A once-daily combination hormone treatment led to reductions in endometriosis-associated pain and opioid use for the duration of a 6-month study.
-
Tackling under-reporting of violence against women Nat. Med. (IF 87.241) Pub Date : 2022-07-28
A large study in India showed that gender-based police interventions — including training, outreach and dedicated spaces staffed by female officers — led to increased reporting of violence against women.
-
Symptoms and risk factors for long COVID in non-hospitalized adults Nat. Med. (IF 87.241) Pub Date : 2022-07-25 Anuradhaa Subramanian, Krishnarajah Nirantharakumar, Sarah Hughes, Puja Myles, Tim Williams, Krishna M. Gokhale, Tom Taverner, Joht Singh Chandan, Kirsty Brown, Nikita Simms-Williams, Anoop D. Shah, Megha Singh, Farah Kidy, Kelvin Okoth, Richard Hotham, Nasir Bashir, Neil Cockburn, Siang Ing Lee, Grace M. Turner, Georgios V. Gkoutos, Olalekan Lee Aiyegbusi, Christel McMullan, Alastair K. Denniston
-
Genetic risk score enhances the risk prediction of severe obesity in adult survivors of childhood cancer Nat. Med. (IF 87.241) Pub Date : 2022-07-25 Yadav Sapkota, Weiyu Qiu, Stephanie B. Dixon, Carmen L. Wilson, Zhaoming Wang, Jinghui Zhang, Wendy Leisenring, Eric J. Chow, Smita Bhatia, Gregory T. Armstrong, Leslie L. Robison, Melissa M. Hudson, Angela Delaney, Yutaka Yasui
-
Long-acting agents for HIV treatment and prevention Nat. Med. (IF 87.241) Pub Date : 2022-07-22 Linda-Gail Bekker
Infrequently dosed, longer-acting antiretroviral agents are making adherence to medication easier, leading to better outcomes for those living with HIV or at risk of infection.
-
A blueprint for eliminating cholera by 2030 Nat. Med. (IF 87.241) Pub Date : 2022-07-22 Md Taufiqul Islam, Allen G. Ross, Adrian C. Sleigh, Fahima Chowdhury, Ashraful Islam Khan, Nigel A. McMillan, Firdausi Qadri
-
Renewed action on hypertension to improve health and reduce global inequalities Nat. Med. (IF 87.241) Pub Date : 2022-07-21
-
Prospective, multi-site study of patient outcomes after implementation of the TREWS machine learning-based early warning system for sepsis Nat. Med. (IF 87.241) Pub Date : 2022-07-21 Roy Adams, Katharine E. Henry, Anirudh Sridharan, Hossein Soleimani, Andong Zhan, Nishi Rawat, Lauren Johnson, David N. Hager, Sara E. Cosgrove, Andrew Markowski, Eili Y. Klein, Edward S. Chen, Mustapha O. Saheed, Maureen Henley, Sheila Miranda, Katrina Houston, Robert C. Linton, Anushree R. Ahluwalia, Albert W. Wu, Suchi Saria
-
Advancing precision oncology with large, real-world genomics and treatment outcomes data Nat. Med. (IF 87.241) Pub Date : 2022-07-21
-
Sleepwalking into the next pandemic Nat. Med. (IF 87.241) Pub Date : 2022-07-21
Governments and funders must prioritize research on emerging and re-emerging infectious diseases such as monkeypox to prevent another pandemic.
-
Harnessing AI in sepsis care Nat. Med. (IF 87.241) Pub Date : 2022-07-21 David W. Bates, Ania Syrowatka
A real-time early warning system for sepsis detection shows promising adoption by healthcare providers and important improvements in patient outcomes.
-
Treat and repeat: oncolytic virus therapy for brain cancer Nat. Med. (IF 87.241) Pub Date : 2022-07-21 John D. Christie, E. Antonio Chiocca
-
Syndemics and clinical science Nat. Med. (IF 87.241) Pub Date : 2022-07-21 Emily Mendenhall, Brandon A. Kohrt, Carmen H. Logie, Alexander C. Tsai
-
Intratumoral oncolytic herpes virus G47∆ for residual or recurrent glioblastoma: a phase 2 trial Nat. Med. (IF 87.241) Pub Date : 2022-07-21 Tomoki Todo, Hirotaka Ito, Yasushi Ino, Hiroshi Ohtsu, Yasunori Ota, Junji Shibahara, Minoru Tanaka
-
Factors driving provider adoption of the TREWS machine learning-based early warning system and its effects on sepsis treatment timing Nat. Med. (IF 87.241) Pub Date : 2022-07-21 Katharine E. Henry, Roy Adams, Cassandra Parent, Hossein Soleimani, Anirudh Sridharan, Lauren Johnson, David N. Hager, Sara E. Cosgrove, Andrew Markowski, Eili Y. Klein, Edward S. Chen, Mustapha O. Saheed, Maureen Henley, Sheila Miranda, Katrina Houston, Robert C. Linton, Anushree R. Ahluwalia, Albert W. Wu, Suchi Saria
-
SCOTUS v. reproductive health in United States Nat. Med. (IF 87.241) Pub Date : 2022-07-20
The US Supreme Court’s majority decision to overturn the constitutional protection of the right to seek an abortion threatens the health of all Americans.
-
A smart solution for detecting ear problems Nat. Med. (IF 87.241) Pub Date : 2022-07-18
Tympanometers to test for ear disorders are costly, so scientists developed a portable and cheap smartphone-based tympanometer for use in resource-limited settings.
-
Hitting the right notes for pain relief Nat. Med. (IF 87.241) Pub Date : 2022-07-18
A study in mice reveals the neuronal mechanisms behind music-induced analgesia, providing a basis for further research and development of alternative pain interventions in humans.
-
Modeling global 80-80-80 blood pressure targets and cardiovascular outcomes Nat. Med. (IF 87.241) Pub Date : 2022-07-18 Sarah J. Pickersgill, William T. Msemburi, Laura Cobb, Nicole Ide, Andrew E. Moran, Yanfang Su, Xinpeng Xu, David A. Watkins
-
Early treatment is a lifeline for infants with SMA Nat. Med. (IF 87.241) Pub Date : 2022-07-15 Charlotte J. Sumner, Thomas O. Crawford
-
Deep brain stimulation for obsessive–compulsive disorder: a crisis of access Nat. Med. (IF 87.241) Pub Date : 2022-07-15 Veerle Visser-Vandewalle, Pablo Andrade, Philip E. Mosley, Benjamin D. Greenberg, Rick Schuurman, Nicole C. McLaughlin, Valerie Voon, Paul Krack, Kelly D. Foote, Helen S. Mayberg, Martijn Figee, Brian H. Kopell, Mircea Polosan, Eileen M. Joyce, Stephan Chabardes, Keith Matthews, Juan C. Baldermann, Himanshu Tyagi, Paul E. Holtzheimer, Chris Bervoets, Clement Hamani, Carine Karachi, Damiaan Denys, Ludvic
-
Fostering drug discovery and development in Africa Nat. Med. (IF 87.241) Pub Date : 2022-07-15 Susan Winks, John G. Woodland, Goonaseelan ‘Colin’ Pillai, Kelly Chibale
-
Uncovering links between parental inflammatory bowel disease and autism in children Nat. Med. (IF 87.241) Pub Date : 2022-07-13
-
A prospective national cohort evaluating ring MVA vaccination as post-exposure prophylaxis for monkeypox Nat. Med. (IF 87.241) Pub Date : 2022-07-13
Discover the world’s best science and medicine | Nature.com
-
Nocturnal habits of circulating tumor cells Nat. Med. (IF 87.241) Pub Date : 2022-07-11
The release of breast cancer cells into the circulation occurs mostly during rest — a surprising discovery that may help researchers to better study and target cancer metastasis.
-
Evolutionary insight into the emergence of SARS-CoV-2 variants of concern Nat. Med. (IF 87.241) Pub Date : 2022-07-08
-
Give credit where it’s due Nat. Med. (IF 87.241) Pub Date : 2022-07-07
Women are credited less than men are in scientific publications and patents; a study suggests that their contributions are systematically under-recognized across all career stages and scientific fields.
-
Comorbidities confound Alzheimer’s blood tests Nat. Med. (IF 87.241) Pub Date : 2022-07-04 Suzanne E. Schindler, Thomas K. Karikari
-
The promise of precision medicine in rheumatology Nat. Med. (IF 87.241) Pub Date : 2022-07-04 Joel M. Guthridge, Catriona A. Wagner, Judith A. James
-
Longitudinal dynamics of clonal hematopoiesis identifies gene-specific fitness effects Nat. Med. (IF 87.241) Pub Date : 2022-07-04 Neil A. Robertson, Eric Latorre-Crespo, Maria Terradas-Terradas, Jorge Lemos-Portela, Alison C. Purcell, Benjamin J. Livesey, Robert F. Hillary, Lee Murphy, Angie Fawkes, Louise MacGillivray, Mhairi Copland, Riccardo E. Marioni, Joseph A. Marsh, Sarah E. Harris, Simon R. Cox, Ian J. Deary, Linus J. Schumacher, Kristina Kirschner, Tamir Chandra
-
Systematic pan-cancer analysis of mutation–treatment interactions using large real-world clinicogenomics data Nat. Med. (IF 87.241) Pub Date : 2022-06-30 Ruishan Liu, Shemra Rizzo, Sarah Waliany, Marius Rene Garmhausen, Navdeep Pal, Zhi Huang, Nayan Chaudhary, Lisa Wang, Chris Harbron, Joel Neal, Ryan Copping, James Zou
-
How better pandemic and epidemic intelligence will prepare the world for future threats Nat. Med. (IF 87.241) Pub Date : 2022-06-28 Oliver W. Morgan, Philip Abdelmalik, Enrique Perez-Gutierrez, Ibrahima Socé Fall, Masaya Kato, Esther Hamblion, Tamano Matsui, Pierre Nabeth, Richard Pebody, Jukka Pukkila, Mary Stephan, Chikwe Ihekweazu
A new approach to pandemic and epidemic intelligence is needed that includes modern approaches to surveillance and risk assessment, as well as improved trust and cooperation between stakeholders and society.
-
Emergence of SARS-CoV-2 Omicron lineages BA.4 and BA.5 in South Africa Nat. Med. (IF 87.241) Pub Date : 2022-06-27 Houriiyah Tegally, Monika Moir, Josie Everatt, Marta Giovanetti, Cathrine Scheepers, Eduan Wilkinson, Kathleen Subramoney, Zinhle Makatini, Sikhulile Moyo, Daniel G. Amoako, Cheryl Baxter, Christian L. Althaus, Ugochukwu J. Anyaneji, Dikeledi Kekana, Raquel Viana, Jennifer Giandhari, Richard J. Lessells, Tongai Maponga, Dorcas Maruapula, Wonderful Choga, Mogomotsi Matshaba, Mpaphi B. Mbulawa, Nokukhanya
Three lineages (BA.1, BA.2 and BA.3) of the SARS-CoV-2 Omicron variant of concern predominantly drove South Africa’s fourth COVID-19 wave. We have now identified two new lineages, BA.4 and BA.5, responsible for a fifth wave of infections. The spike proteins of BA.4 and BA.5 are identical, and comparable to BA.2 except for the addition of 69-70del (present in the Alpha variant and the BA.1 lineage)
-
Rise in ambient temperature is associated with increased mortality in Latin America Nat. Med. (IF 87.241) Pub Date : 2022-06-27
-
A new phase of the Cancer Moonshot to end cancer as we know it Nat. Med. (IF 87.241) Pub Date : 2022-06-27 Dinah S. Singer
Improved screening, novel therapies and a focus on health equity can reduce cancer mortality by 50% in the next 25 years, but these must be underpinned by an investment in basic, translational and clinical research, along with open data.
-
An anti-obesity drug from the diabetes toolbox Nat. Med. (IF 87.241) Pub Date : 2022-06-27
In a phase 3 study, the diabetes drug tirzepatide brought about substantial and sustained weight reduction in adults with obesity.
-
City-level impact of extreme temperatures and mortality in Latin America Nat. Med. (IF 87.241) Pub Date : 2022-06-27 Josiah L. Kephart, Brisa N. Sánchez, Jeffrey Moore, Leah H. Schinasi, Maryia Bakhtsiyarava, Yang Ju, Nelson Gouveia, Waleska T. Caiaffa, Iryna Dronova, Saravanan Arunachalam, Ana V. Diez Roux, Daniel A. Rodríguez
-
Phylogenomic characterization and signs of microevolution in the 2022 multi-country outbreak of monkeypox virus Nat. Med. (IF 87.241) Pub Date : 2022-06-24 Joana Isidro, Vítor Borges, Miguel Pinto, Daniel Sobral, João Dourado Santos, Alexandra Nunes, Verónica Mixão, Rita Ferreira, Daniela Santos, Silvia Duarte, Luís Vieira, Maria José Borrego, Sofia Núncio, Isabel Lopes de Carvalho, Ana Pelerito, Rita Cordeiro, João Paulo Gomes
The largest monkeypox virus (MPXV) outbreak described so far in non-endemic countries was identified in May 20221-6. Here, shotgun metagenomics allowed the rapid reconstruction and phylogenomic characterization of the first MPXV outbreak genome sequences, showing that this MPXV belongs to clade 3 and that the outbreak most likely has a single origin. Although 2022 MPXV (lineage B.1) clustered with