Over half of all infectious diseases that affect humans worldwide can be aggravated by climate change, which highlights the urgency of tough climate action and mitigation measures.

The magnitude of the 2022 multi-country monkeypox virus outbreak has surpassed any preceding outbreak. It is unclear whether asymptomatic or otherwise undiagnosed infections are fuelling this epidemic. We aimed to assess whether undiagnosed infections occurred among men attending a Belgian sexual health clinic in May 2022. We retrospectively screened 224 samples collected for gonorrhoea and chlamydia

Pfizer had successes during COVID-19 by streamlining decisions and running several steps in parallel, a lightspeed approach that can be applied to other diseases.

Ultrasounds can provide a wealth of information on organ function and disease; now scientists have engineered a stick-on wearable ultrasound device for continuous monitoring.

Pigs offer a potentially plentiful supply of organs for humans, but widespread xenotransplantation will require a collaborative and iterative approach to research, as well as involvement of transplant patients and the public.

A once-daily combination hormone treatment led to reductions in endometriosis-associated pain and opioid use for the duration of a 6-month study.

A large study in India showed that gender-based police interventions — including training, outreach and dedicated spaces staffed by female officers — led to increased reporting of violence against women.

Infrequently dosed, longer-acting antiretroviral agents are making adherence to medication easier, leading to better outcomes for those living with HIV or at risk of infection.

Governments and funders must prioritize research on emerging and re-emerging infectious diseases such as monkeypox to prevent another pandemic.

A real-time early warning system for sepsis detection shows promising adoption by healthcare providers and important improvements in patient outcomes.

The US Supreme Court’s majority decision to overturn the constitutional protection of the right to seek an abortion threatens the health of all Americans.

Tympanometers to test for ear disorders are costly, so scientists developed a portable and cheap smartphone-based tympanometer for use in resource-limited settings.

A study in mice reveals the neuronal mechanisms behind music-induced analgesia, providing a basis for further research and development of alternative pain interventions in humans.

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The release of breast cancer cells into the circulation occurs mostly during rest — a surprising discovery that may help researchers to better study and target cancer metastasis.

Women are credited less than men are in scientific publications and patents; a study suggests that their contributions are systematically under-recognized across all career stages and scientific fields.

A new approach to pandemic and epidemic intelligence is needed that includes modern approaches to surveillance and risk assessment, as well as improved trust and cooperation between stakeholders and society.

Three lineages (BA.1, BA.2 and BA.3) of the SARS-CoV-2 Omicron variant of concern predominantly drove South Africa’s fourth COVID-19 wave. We have now identified two new lineages, BA.4 and BA.5, responsible for a fifth wave of infections. The spike proteins of BA.4 and BA.5 are identical, and comparable to BA.2 except for the addition of 69-70del (present in the Alpha variant and the BA.1 lineage)

Improved screening, novel therapies and a focus on health equity can reduce cancer mortality by 50% in the next 25 years, but these must be underpinned by an investment in basic, translational and clinical research, along with open data.

In a phase 3 study, the diabetes drug tirzepatide brought about substantial and sustained weight reduction in adults with obesity.

The largest monkeypox virus (MPXV) outbreak described so far in non-endemic countries was identified in May 20221-6. Here, shotgun metagenomics allowed the rapid reconstruction and phylogenomic characterization of the first MPXV outbreak genome sequences, showing that this MPXV belongs to clade 3 and that the outbreak most likely has a single origin. Although 2022 MPXV (lineage B.1) clustered with