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  • Author Correction: Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017
    Nat. Med. (IF 36.13) Pub Date : 2020-07-02

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

    更新日期:2020-07-03
  • Combining liquid biopsies and PET-CT for early cancer detection
    Nat. Med. (IF 36.13) Pub Date : 2020-06-29
    Stephen Q. Wong; Sarah-Jane Dawson

    A simple blood test performed alongside PET-CT imaging facilitates early cancer detection in asymptomatic women.

    更新日期:2020-06-29
  • Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis
    Nat. Med. (IF 36.13) Pub Date : 2020-06-29
    Stefano Alivernini; Lucy MacDonald; Aziza Elmesmari; Samuel Finlay; Barbara Tolusso; Maria Rita Gigante; Luca Petricca; Clara Di Mario; Laura Bui; Simone Perniola; Moustafa Attar; Marco Gessi; Anna Laura Fedele; Sabarinadh Chilaka; Domenico Somma; Stephen N. Sansom; Andrew Filer; Charles McSharry; Neal L. Millar; Kristina Kirschner; Alessandra Nerviani; Myles J. Lewis; Costantino Pitzalis; Andrew R

    Immune-regulatory mechanisms of drug-free remission in rheumatoid arthritis (RA) are unknown. We hypothesized that synovial tissue macrophages (STM), which persist in remission, contribute to joint homeostasis. We used single-cell transcriptomics to profile 32,000 STMs and identified phenotypic changes in patients with early/active RA, treatment-refractory/active RA and RA in sustained remission. Each

    更新日期:2020-06-29
  • Bacterial and host determinants of cough aerosol culture positivity in patients with drug-resistant versus drug-susceptible tuberculosis
    Nat. Med. (IF 36.13) Pub Date : 2020-06-29
    Grant Theron; Jason Limberis; Rouxjeane Venter; Liezel Smith; Elize Pietersen; Aliasgar Esmail; Greg Calligaro; Julian te Riele; Marianna de Kock; Paul van Helden; Tawanda Gumbo; Taane G. Clark; Kevin Fennelly; Robin Warren; Keertan Dheda

    A burgeoning epidemic of drug-resistant tuberculosis (TB) threatens to derail global control efforts. Although the mechanisms remain poorly clarified, drug-resistant strains are widely believed to be less infectious than drug-susceptible strains. Consequently, we hypothesized that lower proportions of patients with drug-resistant TB would have culturable Mycobacterium tuberculosis from respirable,

    更新日期:2020-06-29
  • Targeting CD70 with cusatuzumab eliminates acute myeloid leukemia stem cells in patients treated with hypomethylating agents
    Nat. Med. (IF 36.13) Pub Date : 2020-06-29
    Carsten Riether; Thomas Pabst; Sabine Höpner; Ulrike Bacher; Magdalena Hinterbrandner; Yara Banz; Rouven Müller; Markus G. Manz; Walid H. Gharib; David Francisco; Remy Bruggmann; Luc van Rompaey; Mahan Moshir; Tim Delahaye; Domenica Gandini; Ellen Erzeel; Anna Hultberg; Samson Fung; Hans de Haard; Nicolas Leupin; Adrian F. Ochsenbein

    Acute myeloid leukemia (AML) is driven by leukemia stem cells (LSCs) that resist conventional chemotherapy and are the major cause of relapse1,2. Hypomethylating agents (HMAs) are the standard of care in the treatment of older or unfit patients with AML, but responses are modest and not durable3,4,5. Here we demonstrate that LSCs upregulate the tumor necrosis factor family ligand CD70 in response to

    更新日期:2020-06-29
  • Pre-existing immunity to influenza virus hemagglutinin stalk might drive selection for antibody-escape mutant viruses in a human challenge model
    Nat. Med. (IF 36.13) Pub Date : 2020-06-29
    Jae-Keun Park; Yongli Xiao; Mitchell D. Ramuta; Luz Angela Rosas; Sharon Fong; Alexis M. Matthews; Ashley D. Freeman; Monica A. Gouzoulis; Natalia A. Batchenkova; Xingdong Yang; Kelsey Scherler; Li Qi; Susan Reed; Rani Athota; Lindsay Czajkowski; Alison Han; David M. Morens; Kathie-Anne Walters; Matthew J. Memoli; John C. Kash; Jeffery K. Taubenberger

    The conserved region of influenza hemagglutinin (HA) stalk (or stem) has gained attention as a potent target for universal influenza vaccines1,2,3,4,5. Although the HA stalk region is relatively well conserved, the evolutionarily dynamic nature of influenza viruses6 raises concerns about the possible emergence of viruses carrying stalk escape mutation(s) under sufficient immune pressure. Here we show

    更新日期:2020-06-29
  • Publisher Correction: Building an international consortium for tracking coronavirus health status
    Nat. Med. (IF 36.13) Pub Date : 2020-06-26
    Eran Segal; Feng Zhang; Xihong Lin; Gary King; Ophir Shalem; Smadar Shilo; William E. Allen; Faisal Alquaddoomi; Han Altae-Tran; Simon Anders; Ran Balicer; Tal Bauman; Ximena Bonilla; Gisel Booman; Andrew T. Chan; Ori Cohen; Silvano Coletti; Natalie Davidson; Yuval Dor; David A. Drew; Olivier Elemento; Georgina Evans; Phil Ewels; Joshua Gale; Amir Gavrieli; Benjamin Geiger; Yonatan H. Grad; Casey S

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

    更新日期:2020-06-26
  • COVID-19 Research in Brief: December, 2019 to June, 2020
    Nat. Med. (IF 36.13) Pub Date : 2020-06-26
    Thiago Carvalho

    In this final roundup of COVID-19 Research in Brief, we look back at 6 months of research

    更新日期:2020-06-26
  • Author Correction: Adaptive evolution of virulence and persistence in carbapenem-resistant Klebsiella pneumoniae
    Nat. Med. (IF 36.13) Pub Date : 2020-06-25
    Christoph M. Ernst; Julian R. Braxton; Carlos A. Rodriguez-Osorio; Anna P. Zagieboylo; Li Li; Alejandro Pironti; Abigail L. Manson; Anil V. Nair; Maura Benson; Kaelyn Cummins; Anne E. Clatworthy; Ashlee M. Earl; Lisa A. Cosimi; Deborah T. Hung

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

    更新日期:2020-06-25
  • Author Correction: A single-cell and single-nucleus RNA-Seq toolbox for fresh and frozen human tumors
    Nat. Med. (IF 36.13) Pub Date : 2020-06-25
    Michal Slyper; Caroline B. M. Porter; Orr Ashenberg; Julia Waldman; Eugene Drokhlyansky; Isaac Wakiro; Christopher Smillie; Gabriela Smith-Rosario; Jingyi Wu; Danielle Dionne; Sébastien Vigneau; Judit Jané-Valbuena; Timothy L. Tickle; Sara Napolitano; Mei-Ju Su; Anand G. Patel; Asa Karlstrom; Simon Gritsch; Masashi Nomura; Avinash Waghray; Satyen H. Gohil; Alexander M. Tsankov; Livnat Jerby-Arnon;

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

    更新日期:2020-06-25
  • Determinants of COVID-19 disease severity in patients with cancer
    Nat. Med. (IF 36.13) Pub Date : 2020-06-24
    Elizabeth V. Robilotti; N. Esther Babady; Peter A. Mead; Thierry Rolling; Rocio Perez-Johnston; Marilia Bernardes; Yael Bogler; Mario Caldararo; Cesar J. Figueroa; Michael S. Glickman; Alexa Joanow; Anna Kaltsas; Yeon Joo Lee; Anabella Lucca; Amanda Mariano; Sejal Morjaria; Tamara Nawar; Genovefa A. Papanicolaou; Jacqueline Predmore; Gil Redelman-Sidi; Elizabeth Schmidt; Susan K. Seo; Kent Sepkowitz;

    As of 10 April 2020, New York State had 180,458 cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and 9,385 reported deaths. Patients with cancer comprised 8.4% of deceased individuals1. Population-based studies from China and Italy suggested a higher coronavirus disease 2019 (COVID-19) death rate in patients with cancer2,3, although there is a knowledge gap as to which aspects

    更新日期:2020-06-24
  • Detection and discrimination of intracranial tumors using plasma cell-free DNA methylomes.
    Nat. Med. (IF 36.13) Pub Date : 2020-06-22
    Farshad Nassiri,Ankur Chakravarthy,Shengrui Feng,Shu Yi Shen,Romina Nejad,Jeffrey A Zuccato,Mathew R Voisin,Vikas Patil,Craig Horbinski,Kenneth Aldape,Gelareh Zadeh,Daniel D De Carvalho

    Definitive diagnosis of intracranial tumors relies on tissue specimens obtained by invasive surgery. Noninvasive diagnostic approaches provide an opportunity to avoid surgery and mitigate unnecessary risk to patients. In the present study, we show that DNA-methylation profiles from plasma reveal highly specific signatures to detect and accurately discriminate common primary intracranial tumors that

    更新日期:2020-06-23
  • A single-cell landscape of high-grade serous ovarian cancer.
    Nat. Med. (IF 36.13) Pub Date : 2020-06-22
    Benjamin Izar,Itay Tirosh,Elizabeth H Stover,Isaac Wakiro,Michael S Cuoco,Idan Alter,Christopher Rodman,Rachel Leeson,Mei-Ju Su,Parin Shah,Marcin Iwanicki,Sarah R Walker,Abhay Kanodia,Johannes C Melms,Shaolin Mei,Jia-Ren Lin,Caroline B M Porter,Michal Slyper,Julia Waldman,Livnat Jerby-Arnon,Orr Ashenberg,Titus J Brinker,Caitlin Mills,Meri Rogava,Sébastien Vigneau,Peter K Sorger,Levi A Garraway,Panagiotis

    Malignant abdominal fluid (ascites) frequently develops in women with advanced high-grade serous ovarian cancer (HGSOC) and is associated with drug resistance and a poor prognosis1. To comprehensively characterize the HGSOC ascites ecosystem, we used single-cell RNA sequencing to profile ~11,000 cells from 22 ascites specimens from 11 patients with HGSOC. We found significant inter-patient variability

    更新日期:2020-06-23
  • Detection of renal cell carcinoma using plasma and urine cell-free DNA methylomes.
    Nat. Med. (IF 36.13) Pub Date : 2020-06-22
    Pier Vitale Nuzzo,Jacob E Berchuck,Keegan Korthauer,Sandor Spisak,Amin H Nassar,Sarah Abou Alaiwi,Ankur Chakravarthy,Shu Yi Shen,Ziad Bakouny,Francesco Boccardo,John Steinharter,Gabrielle Bouchard,Catherine R Curran,Wenting Pan,Sylvan C Baca,Ji-Heui Seo,Gwo-Shu Mary Lee,M Dror Michaelson,Steven L Chang,Sushrut S Waikar,Guru Sonpavde,Rafael A Irizarry,Mark Pomerantz,Daniel D De Carvalho,Toni K Choueiri

    Improving early cancer detection has the potential to substantially reduce cancer-related mortality. Cell-free methylated DNA immunoprecipitation and high-throughput sequencing (cfMeDIP–seq) is a highly sensitive assay capable of detecting early-stage tumors. We report accurate classification of patients across all stages of renal cell carcinoma (RCC) in plasma (area under the receiver operating characteristic

    更新日期:2020-06-23
  • Tau molecular diversity contributes to clinical heterogeneity in Alzheimer's disease.
    Nat. Med. (IF 36.13) Pub Date : 2020-06-22
    Simon Dujardin,Caitlin Commins,Aurelien Lathuiliere,Pieter Beerepoot,Analiese R Fernandes,Tarun V Kamath,Mark B De Los Santos,Naomi Klickstein,Diana L Corjuc,Bianca T Corjuc,Patrick M Dooley,Arthur Viode,Derek H Oakley,Benjamin D Moore,Kristina Mullin,Dinorah Jean-Gilles,Ryan Clark,Kevin Atchison,Renee Moore,Lori B Chibnik,Rudolph E Tanzi,Matthew P Frosch,Alberto Serrano-Pozo,Fiona Elwood,Judith A

    Alzheimer’s disease (AD) causes unrelenting, progressive cognitive impairments, but its course is heterogeneous, with a broad range of rates of cognitive decline1. The spread of tau aggregates (neurofibrillary tangles) across the cerebral cortex parallels symptom severity2,3. We hypothesized that the kinetics of tau spread may vary if the properties of the propagating tau proteins vary across individuals

    更新日期:2020-06-23
  • Human-computer collaboration for skin cancer recognition.
    Nat. Med. (IF 36.13) Pub Date : 2020-06-22
    Philipp Tschandl,Christoph Rinner,Zoe Apalla,Giuseppe Argenziano,Noel Codella,Allan Halpern,Monika Janda,Aimilios Lallas,Caterina Longo,Josep Malvehy,John Paoli,Susana Puig,Cliff Rosendahl,H Peter Soyer,Iris Zalaudek,Harald Kittler

    The rapid increase in telemedicine coupled with recent advances in diagnostic artificial intelligence (AI) create the imperative to consider the opportunities and risks of inserting AI-based support into new paradigms of care. Here we build on recent achievements in the accuracy of image-based AI for skin cancer diagnosis to address the effects of varied representations of AI-based support across different

    更新日期:2020-06-23
  • Author Correction: Integrative molecular and clinical modeling of clinical outcomes to PD1 blockade in patients with metastatic melanoma.
    Nat. Med. (IF 36.13) Pub Date : 2020-06-19
    David Liu,Bastian Schilling,Derek Liu,Antje Sucker,Elisabeth Livingstone,Livnat Jerby-Arnon,Lisa Zimmer,Ralf Gutzmer,Imke Satzger,Carmen Loquai,Stephan Grabbe,Natalie Vokes,Claire A Margolis,Jake Conway,Meng Xiao He,Haitham Elmarakeby,Felix Dietlein,Diana Miao,Adam Tracy,Helen Gogas,Simone M Goldinger,Jochen Utikal,Christian U Blank,Ricarda Rauschenberg,Dagmar von Bubnoff,Angela Krackhardt,Benjamin

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

    更新日期:2020-06-19
  • COVID-19 Research in Brief: 13 June to 19 June, 2020
    Nat. Med. (IF 36.13) Pub Date : 2020-06-19
    Thiago Carvalho

    All the research you need to know to keep on top of how science is responding to the COVID-19 pandemic

    更新日期:2020-06-19
  • Publisher Correction: China needs a national intelligent syndromic surveillance system.
    Nat. Med. (IF 36.13) Pub Date : 2020-06-18
    Peng Jia,Shujuan Yang

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

    更新日期:2020-06-18
  • Publisher Correction: Single-arm, open-label phase 2 trial of pembrolizumab in patients with leptomeningeal carcinomatosis.
    Nat. Med. (IF 36.13) Pub Date : 2020-06-18
    Priscilla K Brastianos,Eudocia Quant Lee,Justine V Cohen,Sara M Tolaney,Nancy U Lin,Nancy Wang,Ugonma Chukwueke,Michael D White,Naema Nayyar,Albert Kim,Christopher Alvarez-Breckenridge,Ian Krop,Maura Keeley Mahar,Mia S Bertalan,Brian Shaw,Joana L Mora,Nathaniel Goss,Megha Subramanian,Lakshmi Nayak,Jorg Dietrich,Deborah A Forst,Brian V Nahed,Tracy T Batchelor,Helen A Shih,Elizabeth R Gerstner,Beverly

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

    更新日期:2020-06-18
  • Publisher Correction: Safety and feasibility of CRISPR-edited T cells in patients with refractory non-small-cell lung cancer.
    Nat. Med. (IF 36.13) Pub Date : 2020-06-18
    You Lu,Jianxin Xue,Tao Deng,Xiaojuan Zhou,Kun Yu,Lei Deng,Meijuan Huang,Xin Yi,Maozhi Liang,Yu Wang,Haige Shen,Ruizhan Tong,Wenbo Wang,Li Li,Jin Song,Jing Li,Xiaoxing Su,Zhenyu Ding,Youling Gong,Jiang Zhu,Yongsheng Wang,Bingwen Zou,Yan Zhang,Yanying Li,Lin Zhou,Yongmei Liu,Min Yu,Yuqi Wang,Xuanwei Zhang,Limei Yin,Xuefeng Xia,Yong Zeng,Qiao Zhou,Binwu Ying,Chong Chen,Yuquan Wei,Weimin Li,Tony Mok

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

    更新日期:2020-06-18
  • Clinical and immunological assessment of asymptomatic SARS-CoV-2 infections.
    Nat. Med. (IF 36.13) Pub Date : 2020-06-18
    Quan-Xin Long,Xiao-Jun Tang,Qiu-Lin Shi,Qin Li,Hai-Jun Deng,Jun Yuan,Jie-Li Hu,Wei Xu,Yong Zhang,Fa-Jin Lv,Kun Su,Fan Zhang,Jiang Gong,Bo Wu,Xia-Mao Liu,Jin-Jing Li,Jing-Fu Qiu,Juan Chen,Ai-Long Huang

    The clinical features and immune responses of asymptomatic individuals infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have not been well described. We studied 37 asymptomatic individuals in the Wanzhou District who were diagnosed with RT–PCR-confirmed SARS-CoV-2 infections but without any relevant clinical symptoms in the preceding 14 d and during hospitalization. Asymptomatic

    更新日期:2020-06-18
  • Age-dependent effects in the transmission and control of COVID-19 epidemics.
    Nat. Med. (IF 36.13) Pub Date : 2020-06-16
    Nicholas G Davies,Petra Klepac,Yang Liu,Kiesha Prem,Mark Jit,,Rosalind M Eggo

    The COVID-19 pandemic has shown a markedly low proportion of cases among children1,2,3,4. Age disparities in observed cases could be explained by children having lower susceptibility to infection, lower propensity to show clinical symptoms or both. We evaluate these possibilities by fitting an age-structured mathematical model to epidemic data from China, Italy, Japan, Singapore, Canada and South Korea

    更新日期:2020-06-16
  • Disease and healthcare burden of COVID-19 in the United States.
    Nat. Med. (IF 36.13) Pub Date : 2020-06-16
    Ian F Miller,Alexander D Becker,Bryan T Grenfell,C Jessica E Metcalf

    As of 24 April 2020, the SARS-CoV-2 epidemic has resulted in over 830,000 confirmed infections in the United States1. The incidence of COVID-19, the disease associated with this new coronavirus, continues to rise. The epidemic threatens to overwhelm healthcare systems, and identifying those regions where the disease burden is likely to be high relative to the rest of the country is critical for enabling

    更新日期:2020-06-16
  • Biobanks could identify medically actionable findings relevant for COVID-19 clinical care.
    Nat. Med. (IF 36.13) Pub Date : 2020-06-15
    Andrew B Stergachis,Scott T Weiss,Robert C Green

    更新日期:2020-06-15
  • COVID-19 Research in Brief: 6 June to 12 June, 2020
    Nat. Med. (IF 36.13) Pub Date : 2020-06-12
    Thiago Carvalho

    All the research you need to know to keep on top of how science is responding to the COVID-19 pandemic

    更新日期:2020-06-12
  • Mapping postprandial responses sets the scene for targeted dietary advice.
    Nat. Med. (IF 36.13) Pub Date : 2020-06-11
    Jennie Brand-Miller,Anette Buyken

    A machine-learning model can predict differences between people in how they respond to meals.

    更新日期:2020-06-11
  • Human postprandial responses to food and potential for precision nutrition.
    Nat. Med. (IF 36.13) Pub Date : 2020-06-11
    Sarah E Berry,Ana M Valdes,David A Drew,Francesco Asnicar,Mohsen Mazidi,Jonathan Wolf,Joan Capdevila,George Hadjigeorgiou,Richard Davies,Haya Al Khatib,Christopher Bonnett,Sajaysurya Ganesh,Elco Bakker,Deborah Hart,Massimo Mangino,Jordi Merino,Inbar Linenberg,Patrick Wyatt,Jose M Ordovas,Christopher D Gardner,Linda M Delahanty,Andrew T Chan,Nicola Segata,Paul W Franks,Tim D Spector

    Metabolic responses to food influence risk of cardiometabolic disease, but large-scale high-resolution studies are lacking. We recruited n = 1,002 twins and unrelated healthy adults in the United Kingdom to the PREDICT 1 study and assessed postprandial metabolic responses in a clinical setting and at home. We observed large inter-individual variability (as measured by the population coefficient of

    更新日期:2020-06-11
  • COVID-19 in Africa: the spread and response.
    Nat. Med. (IF 36.13) Pub Date : 2020-06-11
    Marguerite Massinga Loembé,Akhona Tshangela,Stephanie J Salyer,Jay K Varma,Ahmed E Ogwell Ouma,John N Nkengasong

    Given the current trends in incidence and underlying healthcare systems vulnerabilities, Africa could become the next epicenter of the COVID-19 pandemic. As the pandemic transitions to more widespread community transmission, how can the lessons learned thus far be consolidated to effectively curb the spread of COVID-19 while minimizing social disruption and negative humanitarian and economic consequences

    更新日期:2020-06-11
  • Keeping governments accountable: the COVID-19 Assessment Scorecard (COVID-SCORE).
    Nat. Med. (IF 36.13) Pub Date : 2020-06-11
    Jeffrey V Lazarus,Agnes Binagwaho,Ayman A E El-Mohandes,Jonathan E Fielding,Heidi J Larson,Antoni Plasència,Vytenis Andriukaitis,Scott C Ratzan

    Many actors in the response to COVID-19 are holding out for a vaccine to be developed. But in the meantime, tried and tested public-health measures for controlling outbreaks can be implemented. A scorecard can be used to assess governments’ responses to the outbreak.

    更新日期:2020-06-11
  • Socio-demographic and epidemiological consideration of Africa's COVID-19 response: what is the possible pandemic course?
    Nat. Med. (IF 36.13) Pub Date : 2020-06-11
    Bamba Gaye,Stéphanie Khoury,Crystal W Cene,Samuel Kingue,Roland N'Guetta,Camille Lassale,Dadhi Baldé,Ibrahima Bara Diop,Jennifer Beam Dowd,Melinda C Mills,Xavier Jouven

    Africa is said to be the next possible hotspot for COVID-19. However, we believe this is still preventable.

    更新日期:2020-06-11
  • Ten recommendations for supporting open pathogen genomic analysis in public health.
    Nat. Med. (IF 36.13) Pub Date : 2020-06-11
    Allison Black,Duncan R MacCannell,Thomas R Sibley,Trevor Bedford

    Increasingly, public-health agencies are using pathogen genomic sequence data to support surveillance and epidemiological investigations. As access to whole-genome sequencing has grown, greater amounts of molecular data have helped improve the ability to detect and track outbreaks of diseases such as COVID-19, investigate transmission chains and explore large-scale population dynamics, such as the

    更新日期:2020-06-11
  • Uncovering hidden antimicrobial resistance patterns within the hospital microbiome.
    Nat. Med. (IF 36.13) Pub Date : 2020-06-08
    Bastiaan W Haak,W Joost Wiersinga

    Combined culture-dependent and culture-independent metagenomic sequencing methods reveal the pervasive and long-lasting presence of antimicrobial resistance genes within a tertiary hospital environment.

    更新日期:2020-06-08
  • Cartography of opportunistic pathogens and antibiotic resistance genes in a tertiary hospital environment.
    Nat. Med. (IF 36.13) Pub Date : 2020-06-08
    Kern Rei Chng,Chenhao Li,Denis Bertrand,Amanda Hui Qi Ng,Junmei Samantha Kwah,Hwee Meng Low,Chengxuan Tong,Maanasa Natrajan,Michael Hongjie Zhang,Licheng Xu,Karrie Kwan Ki Ko,Eliza Xin Pei Ho,Tamar V Av-Shalom,Jeanette Woon Pei Teo,Chiea Chuen Khor,,Swaine L Chen,Christopher E Mason,Oon Tek Ng,Kalisvar Marimuthu,Brenda Ang,Niranjan Nagarajan

    Although disinfection is key to infection control, the colonization patterns and resistomes of hospital-environment microbes remain underexplored. We report the first extensive genomic characterization of microbiomes, pathogens and antibiotic resistance cassettes in a tertiary-care hospital, from repeated sampling (up to 1.5 years apart) of 179 sites associated with 45 beds. Deep shotgun metagenomics

    更新日期:2020-06-08
  • Preserve junior faculty in biomedical sciences during and after the pandemic.
    Nat. Med. (IF 36.13) Pub Date : 2020-06-08
    Prachee Avasthi,Ushma S Neill,Keshia M Pollack Porter,Ashani T Weeraratna

    COVID-19 has disrupted scientific productivity in unquantifiable ways. Unquestionably, the biggest disruption has been felt by junior faculty. However, these bright young minds do not have to be sacrificed.

    更新日期:2020-06-08
  • Reconstruction of the human blood-brain barrier in vitro reveals a pathogenic mechanism of APOE4 in pericytes.
    Nat. Med. (IF 36.13) Pub Date : 2020-06-08
    Joel W Blanchard,Michael Bula,Jose Davila-Velderrain,Leyla Anne Akay,Lena Zhu,Alexander Frank,Matheus B Victor,Julia Maeve Bonner,Hansruedi Mathys,Yuan-Ta Lin,Tak Ko,David A Bennett,Hugh P Cam,Manolis Kellis,Li-Huei Tsai

    In Alzheimer’s disease, amyloid deposits along the brain vasculature lead to a condition known as cerebral amyloid angiopathy (CAA), which impairs blood–brain barrier (BBB) function and accelerates cognitive degeneration. Apolipoprotein (APOE4) is the strongest risk factor for CAA, yet the mechanisms underlying this genetic susceptibility are unknown. Here we developed an induced pluripotent stem cell-based

    更新日期:2020-06-08
  • A single-cell atlas of the peripheral immune response in patients with severe COVID-19.
    Nat. Med. (IF 36.13) Pub Date : 2020-06-08
    Aaron J Wilk,Arjun Rustagi,Nancy Q Zhao,Jonasel Roque,Giovanny J Martínez-Colón,Julia L McKechnie,Geoffrey T Ivison,Thanmayi Ranganath,Rosemary Vergara,Taylor Hollis,Laura J Simpson,Philip Grant,Aruna Subramanian,Angela J Rogers,Catherine A Blish

    There is an urgent need to better understand the pathophysiology of Coronavirus disease 2019 (COVID-19), the global pandemic caused by SARS-CoV-2, which has infected more than three million people worldwide1. Approximately 20% of patients with COVID-19 develop severe disease and 5% of patients require intensive care2. Severe disease has been associated with changes in peripheral immune activity, including

    更新日期:2020-06-08
  • Developing specific reporting guidelines for diagnostic accuracy studies assessing AI interventions: The STARD-AI Steering Group.
    Nat. Med. (IF 36.13) Pub Date : 2020-06-01
    Viknesh Sounderajah,Hutan Ashrafian,Ravi Aggarwal,Jeffrey De Fauw,Alastair K Denniston,Felix Greaves,Alan Karthikesalingam,Dominic King,Xiaoxuan Liu,Sheraz R Markar,Matthew D F McInnes,Trishan Panch,Jonathan Pearson-Stuttard,Daniel S W Ting,Robert M Golub,David Moher,Patrick M Bossuyt,Ara Darzi

    更新日期:2020-06-08
  • Seroprevalence of immunoglobulin M and G antibodies against SARS-CoV-2 in China.
    Nat. Med. (IF 36.13) Pub Date : 2020-06-05
    Xin Xu,Jian Sun,Sheng Nie,Huiyuan Li,Yaozhong Kong,Min Liang,Jinlin Hou,Xianzhong Huang,Dongfeng Li,Tean Ma,Jiaqing Peng,Shikui Gao,Yong Shao,Hong Zhu,Johnson Yiu-Nam Lau,Guangyu Wang,Chunbao Xie,Li Jiang,Ailong Huang,Zhenglin Yang,Kang Zhang,Fan Fan Hou

    Detection of asymptomatic or subclinical novel human coronavirus SARS-CoV-2 infection is critical for understanding the overall prevalence and infection potential of COVID-19. To estimate the cumulative prevalence of SARS-CoV-2 infection in China, we evaluated the host serologic response, measured by the levels of immunoglobulins M and G in 17,368 individuals, in the city of Wuhan, the epicenter of

    更新日期:2020-06-05
  • COVID-19 Research in Brief: 30 May to 5 June, 2020
    Nat. Med. (IF 36.13) Pub Date : 2020-06-05
    Thiago Carvalho

    All the research you need to know to keep on top of how science is responding to the COVID-19 pandemic

    更新日期:2020-06-05
  • It is not the time for science fiction.
    Nat. Med. (IF 36.13) Pub Date : 2020-06-04

    Government officials who disseminate unsupported claims about the novel coronavirus undermine public trust in science and in the public-health efforts that are essential to bringing the COVID-19 pandemic under control.

    更新日期:2020-06-04
  • Author Correction: Caring for patients with cancer in the COVID-19 era.
    Nat. Med. (IF 36.13) Pub Date : 2020-06-03
    Joris van de Haar,Louisa R Hoes,Charlotte E Coles,Kenneth Seamon,Stefan Fröhling,Dirk Jäger,Franco Valenza,Filippo de Braud,Luigi De Petris,Jonas Bergh,Ingemar Ernberg,Benjamin Besse,Fabrice Barlesi,Elena Garralda,Alejandro Piris-Giménez,Michael Baumann,Giovanni Apolone,Jean Charles Soria,Josep Tabernero,Carlos Caldas,Emile E Voest

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

    更新日期:2020-06-03
  • Publisher Correction: Spatial heterogeneity of the T cell receptor repertoire reflects the mutational landscape in lung cancer.
    Nat. Med. (IF 36.13) Pub Date : 2020-06-03
    Kroopa Joshi,Marc Robert de Massy,Mazlina Ismail,James L Reading,Imran Uddin,Annemarie Woolston,Emine Hatipoglu,Theres Oakes,Rachel Rosenthal,Thomas Peacock,Tahel Ronel,Mahdad Noursadeghi,Virginia Turati,Andrew J S Furness,Andrew Georgiou,Yien Ning Sophia Wong,Assma Ben Aissa,Mariana Werner Sunderland,Mariam Jamal-Hanjani,Selvaraju Veeriah,Nicolai J Birkbak,Gareth A Wilson,Crispin T Hiley,Ehsan Ghorani

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

    更新日期:2020-06-03
  • Publisher Correction: Pulmonary venous circulating tumor cell dissemination before tumor resection and disease relapse.
    Nat. Med. (IF 36.13) Pub Date : 2020-06-03
    Francesca Chemi,Dominic G Rothwell,Nicholas McGranahan,Sakshi Gulati,Chris Abbosh,Simon P Pearce,Cong Zhou,Gareth A Wilson,Mariam Jamal-Hanjani,Nicolai Birkbak,Jackie Pierce,Chang Sik Kim,Saba Ferdous,Deborah J Burt,Daniel Slane-Tan,Fabio Gomes,David Moore,Rajesh Shah,Maise Al Bakir,Crispin Hiley,Selvaraju Veeriah,Yvonne Summers,Philip Crosbie,Sophia Ward,Barbara Mesquita,Marek Dynowski,Dhruva Biswas

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

    更新日期:2020-06-03
  • Publisher Correction: A clonal expression biomarker associates with lung cancer mortality.
    Nat. Med. (IF 36.13) Pub Date : 2020-06-03
    Dhruva Biswas,Nicolai J Birkbak,Rachel Rosenthal,Crispin T Hiley,Emilia L Lim,Krisztian Papp,Stefan Boeing,Marcin Krzystanek,Dijana Djureinovic,Linnea La Fleur,Maria Greco,Balázs Döme,János Fillinger,Hans Brunnström,Yin Wu,David A Moore,Marcin Skrzypski,Christopher Abbosh,Kevin Litchfield,Maise Al Bakir,Thomas B K Watkins,Selvaraju Veeriah,Gareth A Wilson,Mariam Jamal-Hanjani,Judit Moldvay,Johan Botling

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

    更新日期:2020-06-03
  • Building an international consortium for tracking coronavirus health status.
    Nat. Med. (IF 36.13) Pub Date : 2020-06-02
    Eran Segal,Feng Zhang,Xihong Lin,Gary King,Ophir Shalem,Smadar Shilo,William E Allen,Faisal Alquaddoomi,Han Altae-Tran,Simon Anders,Ran Balicer,Tal Bauman,Ximena Bonilla,Gisel Booman,Andrew T Chan,Ori Cohen,Silvano Coletti,Natalie Davidson,Yuval Dor,David A Drew,Olivier Elemento,Georgina Evans,Phil Ewels,Joshua Gale,Amir Gavrieli,Benjamin Geiger,Yonatan H Grad,Casey S Greene,Iman Hajirasouliha,Roman

    We call upon the research community to standardize efforts to use daily self-reported data about COVID-19 symptoms in the response to the pandemic and to form a collaborative consortium to maximize global gain while protecting participant privacy.

    更新日期:2020-06-02
  • Understanding the ketogenic diet.
    Nat. Med. (IF 36.13) Pub Date : 2020-06-01
    Hannah Stower

    更新日期:2020-06-01
  • Kawasaki disease in a COVID-19-struck region.
    Nat. Med. (IF 36.13) Pub Date : 2020-06-01
    Hannah Stower

    更新日期:2020-06-01
  • A personal approach for Parkinson's disease.
    Nat. Med. (IF 36.13) Pub Date : 2020-06-01
    Hannah Stower

    更新日期:2020-06-01
  • T cells as regulators of senescence.
    Nat. Med. (IF 36.13) Pub Date : 2020-06-01
    Hannah Stower

    更新日期:2020-06-01
  • Vaccination combats antimicrobial resistance.
    Nat. Med. (IF 36.13) Pub Date : 2020-06-01
    Hannah Stower

    更新日期:2020-06-01
  • Single-arm, open-label phase 2 trial of pembrolizumab in patients with leptomeningeal carcinomatosis.
    Nat. Med. (IF 36.13) Pub Date : 2020-06-01
    Priscilla K Brastianos,Eudocia Quant Lee,Justine V Cohen,Sara M Tolaney,Nancy U Lin,Nancy Wang,Ugonma Chukwueke,Michael D White,Naema Nayyar,Albert Kim,Christopher Alvarez-Breckenridge,Ian Krop,Maura Keeley Mahar,Mia S Bertalan,Brian Shaw,Joana L Mora,Nathaniel Goss,Megha Subramanian,Lakshmi Nayak,Jorg Dietrich,Deborah A Forst,Brian V Nahed,Tracy T Batchelor,Helen A Shih,Elizabeth R Gerstner,Beverly

    An increasing fraction of patients with metastatic cancer develop leptomeningeal dissemination of disease (LMD), and survival is dismal1,2,3. We conducted a single-arm, phase 2 study of pembrolizumab in patients with solid tumor malignancies and LMD (NCT02886585). Patients received 200 mg of pembrolizumab intravenously every 3 weeks until definitive progression or unacceptable toxicity. The primary

    更新日期:2020-06-01
  • Author Correction: Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer.
    Nat. Med. (IF 36.13) Pub Date : 2020-06-01
    Kirsten L Bryant,Clint A Stalnecker,Daniel Zeitouni,Jennifer E Klomp,Sen Peng,Andrey P Tikunov,Venugopal Gunda,Mariaelena Pierobon,Andrew M Waters,Samuel D George,Garima Tomar,Björn Papke,G Aaron Hobbs,Liang Yan,Tikvah K Hayes,J Nathaniel Diehl,Gennifer D Goode,Nina V Chaika,Yingxue Wang,Guo-Fang Zhang,Agnieszka K Witkiewicz,Erik S Knudsen,Emanuel F Petricoin,Pankaj K Singh,Jeffrey M Macdonald,Nhan

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

    更新日期:2020-06-01
  • IgG-cleaving endopeptidase enables in vivo gene therapy in the presence of anti-AAV neutralizing antibodies.
    Nat. Med. (IF 36.13) Pub Date : 2020-06-01
    Christian Leborgne,Elena Barbon,Jeffrey M Alexander,Hayley Hanby,Sandrine Delignat,Daniel M Cohen,Fanny Collaud,Saghana Muraleetharan,Dan Lupo,Joseph Silverberg,Karen Huang,Laetitia van Wittengerghe,Béatrice Marolleau,Adeline Miranda,Anna Fabiano,Victoria Daventure,Heena Beck,Xavier M Anguela,Giuseppe Ronzitti,Sean M Armour,Sebastien Lacroix-Desmazes,Federico Mingozzi

    Neutralizing antibodies to adeno-associated virus (AAV) vectors are highly prevalent in humans1,2, and block liver transduction3,4,5 and vector readministration6; thus, they represent a major limitation to in vivo gene therapy. Strategies aimed at overcoming anti-AAV antibodies are being studied7, which often involve immunosuppression and are not efficient in removing pre-existing antibodies. Imlifidase

    更新日期:2020-06-01
  • Colibactin DNA-damage signature indicates mutational impact in colorectal cancer.
    Nat. Med. (IF 36.13) Pub Date : 2020-06-01
    Paulina J Dziubańska-Kusibab,Hilmar Berger,Federica Battistini,Britta A M Bouwman,Amina Iftekhar,Riku Katainen,Tatiana Cajuso,Nicola Crosetto,Modesto Orozco,Lauri A Aaltonen,Thomas F Meyer

    The mucosal epithelium is a common target of damage by chronic bacterial infections and the accompanying toxins, and most cancers originate from this tissue. We investigated whether colibactin, a potent genotoxin1 associated with certain strains of Escherichia coli2, creates a specific DNA-damage signature in infected human colorectal cells. Notably, the genomic contexts of colibactin-induced DNA double-strand

    更新日期:2020-06-01
  • Genome-wide cell-free DNA mutational integration enables ultra-sensitive cancer monitoring.
    Nat. Med. (IF 36.13) Pub Date : 2020-06-01
    Asaf Zviran,Rafael C Schulman,Minita Shah,Steven T K Hill,Sunil Deochand,Cole C Khamnei,Dillon Maloney,Kristofer Patel,Will Liao,Adam J Widman,Phillip Wong,Margaret K Callahan,Gavin Ha,Sarah Reed,Denisse Rotem,Dennie Frederick,Tatyana Sharova,Benchun Miao,Tommy Kim,Greg Gydush,Justin Rhoades,Kevin Y Huang,Nathaniel D Omans,Patrick O Bolan,Andrew H Lipsky,Chelston Ang,Murtaza Malbari,Catherine F Spinelli

    In many areas of oncology, we lack sensitive tools to track low-burden disease. Although cell-free DNA (cfDNA) shows promise in detecting cancer mutations, we found that the combination of low tumor fraction (TF) and limited number of DNA fragments restricts low-disease-burden monitoring through the prevailing deep targeted sequencing paradigm. We reasoned that breadth may supplant depth of sequencing

    更新日期:2020-06-01
  • COVID-19 Research in Brief: 23 May to 29 May, 2020
    Nat. Med. (IF 36.13) Pub Date : 2020-05-29
    Thiago Carvalho

    All the research you need to know to keep on top of how science is responding to the COVID-19 pandemic

    更新日期:2020-05-29
  • Interplay of somatic alterations and immune infiltration modulates response to PD-1 blockade in advanced clear cell renal cell carcinoma.
    Nat. Med. (IF 36.13) Pub Date : 2020-05-29
    David A Braun,Yue Hou,Ziad Bakouny,Miriam Ficial,Miriam Sant' Angelo,Juliet Forman,Petra Ross-Macdonald,Ashton C Berger,Opeyemi A Jegede,Liudmilla Elagina,John Steinharter,Maxine Sun,Megan Wind-Rotolo,Jean-Christophe Pignon,Andrew D Cherniack,Lee Lichtenstein,Donna Neuberg,Paul Catalano,Gordon J Freeman,Arlene H Sharpe,David F McDermott,Eliezer M Van Allen,Sabina Signoretti,Catherine J Wu,Sachet A

    PD-1 blockade has transformed the management of advanced clear cell renal cell carcinoma (ccRCC), but the drivers and resistors of the PD-1 response remain incompletely elucidated. Here, we analyzed 592 tumors from patients with advanced ccRCC enrolled in prospective clinical trials of treatment with PD-1 blockade by whole-exome and RNA sequencing, integrated with immunofluorescence analysis, to uncover

    更新日期:2020-05-29
  • Author Correction: Respiratory virus shedding in exhaled breath and efficacy of face masks.
    Nat. Med. (IF 36.13) Pub Date : 2020-05-27
    Nancy H L Leung,Daniel K W Chu,Eunice Y C Shiu,Kwok-Hung Chan,James J McDevitt,Benien J P Hau,Hui-Ling Yen,Yuguo Li,Dennis K M Ip,J S Malik Peiris,Wing-Hong Seto,Gabriel M Leung,Donald K Milton,Benjamin J Cowling

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

    更新日期:2020-05-27
  • Geospatial immune variability illuminates differential evolution of lung adenocarcinoma.
    Nat. Med. (IF 36.13) Pub Date : 2020-05-27
    Khalid AbdulJabbar,Shan E Ahmed Raza,Rachel Rosenthal,Mariam Jamal-Hanjani,Selvaraju Veeriah,Ayse Akarca,Tom Lund,David A Moore,Roberto Salgado,Maise Al Bakir,Luis Zapata,Crispin T Hiley,Leah Officer,Marco Sereno,Claire Rachel Smith,Sherene Loi,Allan Hackshaw,Teresa Marafioti,Sergio A Quezada,Nicholas McGranahan,John Le Quesne,,Charles Swanton,Yinyin Yuan

    Remarkable progress in molecular analyses has improved our understanding of the evolution of cancer cells toward immune escape1,2,3,4,5. However, the spatial configurations of immune and stromal cells, which may shed light on the evolution of immune escape across tumor geographical locations, remain unaddressed. We integrated multiregion exome and RNA-sequencing (RNA-seq) data with spatial histology

    更新日期:2020-05-27
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