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Computational design of serine hydrolases Science (IF 44.7) Pub Date : 2025-02-13 Anna Lauko, Samuel J. Pellock, Kiera H. Sumida, Ivan Anishchenko, David Juergens, Woody Ahern, Jihun Jeung, Alex Shida, Andrew Hunt, Indrek Kalvet, Christoffer Norn, Ian R. Humphreys, Cooper Jamieson, Rohith Krishna, Yakov Kipnis, Alex Kang, Evans Brackenbrough, Asim K. Bera, Banumathi Sankaran, K. N. Houk, David Baker
The design of enzymes with complex active sites that mediate multistep reactions remains an outstanding challenge. With serine hydrolases as a model system, we combined the generative capabilities of RFdiffusion with an ensemble generation method for assessing active site preorganization to design enzymes starting from minimal active site descriptions. Experimental characterization revealed catalytic
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Vapor pressure deficit dominates dryness stress on forest biomass carbon in China under global warming Agric. For. Meteorol. (IF 5.6) Pub Date : 2025-02-12 Yunfeng Cen, Mei Tang, Qingyuan Wang, Guanfang Sun, Zhiming Han, Yonghong Li, Zhaoliang Gao
Soil moisture (SM) and vapor pressure deficit (VPD) are key factors affecting forest carbon stock. However, their effects on forest biomass carbon under hotter and drier climate trends are unclear. These knowledge gaps limit forest management practices and the implementation of climate change mitigation programs. In this study, satellite observations and meteorological data were combined to analyze
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Author Correction: India–Eurasia convergence speed-up by passive-margin sediment subduction Nature (IF 50.5) Pub Date : 2025-02-13 Hao Zhou, Jiashun Hu, Luca Dal Zilio, Ming Tang, Keqing Li, Xiumian Hu
Correction to: Nature https://doi.org/10.1038/s41586-024-08069-6 Published online 6 November 2024
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Publisher Correction: Immune evasion through mitochondrial transfer in the tumour microenvironment Nature (IF 50.5) Pub Date : 2025-02-13 Hideki Ikeda, Katsushige Kawase, Tatsuya Nishi, Tomofumi Watanabe, Keizo Takenaga, Takashi Inozume, Takamasa Ishino, Sho Aki, Jason Lin, Shusuke Kawashima, Joji Nagasaki, Youki Ueda, Shinichiro Suzuki, Hideki Makinoshima, Makiko Itami, Yuki Nakamura, Yasutoshi Tatsumi, Yusuke Suenaga, Takao Morinaga, Akiko Honobe-Tabuchi, Takehiro Ohnuma, Tatsuyoshi Kawamura, Yoshiyasu Umeda, Yasuhiro Nakamura, Yukiko
Correction to: Nature https://doi.org/10.1038/s41586-024-08439-0 Published online 22 January 2025
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Are the Trump team’s actions affecting your research? How to contact Nature Nature (IF 50.5) Pub Date : 2025-02-13
Use this form to share information with Nature’s news team, or to make suggestions for future coverage.
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Are PhDs losing their lustre? Why fewer students are enrolling in doctoral degrees Nature (IF 50.5) Pub Date : 2025-02-13
High living costs paired with stagnant stipends are being blamed for a drop in PhD enrolments in several countries.
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The researchers on a quest to protect the gut from antibiotics Nature (IF 50.5) Pub Date : 2025-02-13
The crucial drugs can have unintended consequences. Innovative therapies could shield the microbiome from their effects.
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σ-Bond insertion reactions of two strained diradicaloids Nature (IF 50.5) Pub Date : 2025-02-12 Arismel Tena Meza, Christina A. Rivera, Huiling Shao, Andrew V. Kelleghan, K. N. Houk, Neil K. Garg
The development of new synthetic methodologies are instrumental for enabling the discovery of new medicines. Those methods that provide efficient access to structural alternatives for aromatic compounds (i.e., saturated arene bioisosteres), have become highly coveted.1,2,3,4 The incorporation of such bioisosteres typically leads to favorable drug-like properties and represents an emerging field of
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Observation of Plastic Ice VII by Quasi-Elastic Neutron Scattering Nature (IF 50.5) Pub Date : 2025-02-12 Maria Rescigno, Alberto Toffano, Umbertoluca Ranieri, Leon Andriambariarijaona, Richard Gaal, Stefan Klotz, Michael Marek Koza, Jacques Ollivier, Fausto Martelli, John Russo, Francesco Sciortino, Jose Teixeira, Livia Eleonora Bove
Water is the third most abundant molecule in the universe and a key component in the interiors of icy moons, giant planets, and Uranus- and Neptune-like exoplanets1–3. Owing to its distinct molecular structure and flexible hydrogen bonds that readily adapt to a wide range of pressures and temperatures, water forms numerous crystalline and amorphous phases4–6. Most relevant for the high pressures and
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Cheap blood test detects pancreatic cancer before it spreads Nature (IF 50.5) Pub Date : 2025-02-12
The deadly cancer is often not found until it has spread to other parts of the body.
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Gourmet cockatoos like to fancy up their food Nature (IF 50.5) Pub Date : 2025-02-12
Make mine blueberry: Goffin’s cockatoos add flair to plain vegetables with a dip into fruity soy yogurt.
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Observation of an ultra-high-energy cosmic neutrino with KM3NeT Nature (IF 50.5) Pub Date : 2025-02-12
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Learning produces an orthogonalized state machine in the hippocampus Nature (IF 50.5) Pub Date : 2025-02-12 Weinan Sun, Johan Winnubst, Maanasa Natrajan, Chongxi Lai, Koichiro Kajikawa, Arco Bast, Michalis Michaelos, Rachel Gattoni, Carsen Stringer, Daniel Flickinger, James E. Fitzgerald, Nelson Spruston
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Transcriptional adaptation upregulates utrophin in Duchenne muscular dystrophy Nature (IF 50.5) Pub Date : 2025-02-12 Lara Falcucci, Christopher M. Dooley, Douglas Adamoski, Thomas Juan, Justin Martinez, Angelina M. Georgieva, Kamel Mamchaoui, Cansu Cirzi, Didier Y. R. Stainier
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Transcriptomic neuron types vary topographically in function and morphology Nature (IF 50.5) Pub Date : 2025-02-12 Inbal Shainer, Johannes M. Kappel, Eva Laurell, Joseph C. Donovan, Martin W. Schneider, Enrico Kuehn, Irene Arnold-Ammer, Manuel Stemmer, Johannes Larsch, Herwig Baier
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Topological segregation of stress sensors along the gut crypt–villus axis Nature (IF 50.5) Pub Date : 2025-02-12 Kouki K. Touhara, Nathan D. Rossen, Fei Deng, Joel Castro, Andrea M. Harrington, Tifany Chu, Sonia Garcia-Caraballo, Mariana Brizuela, Tracey O’Donnell, Jinhao Xu, Onur Cil, Stuart M. Brierley, Yulong Li, David Julius
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A metagenomic ‘dark matter’ enzyme catalyses oxidative cellulose conversion Nature (IF 50.5) Pub Date : 2025-02-12 Clelton A. Santos, Mariana A. B. Morais, Fernanda Mandelli, Evandro A. Lima, Renan Y. Miyamoto, Paula M. R. Higasi, Evandro A. Araujo, Douglas A. A. Paixão, Joaquim M. Junior, Maria L. Motta, Rodrigo S. A. Streit, Luana G. Morão, Claudio B. C. Silva, Lucia D. Wolf, Cesar R. F. Terrasan, Nathalia R. Bulka, Jose A. Diogo, Felipe J. Fuzita, Felippe M. Colombari, Camila R. Santos, Priscila T. Rodrigues
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UM171 glues asymmetric CRL3–HDAC1/2 assembly to degrade CoREST corepressors Nature (IF 50.5) Pub Date : 2025-02-12 Megan J. R. Yeo, Olivia Zhang, Xiaowen Xie, Eunju Nam, N. Connor Payne, Pallavi M. Gosavi, Hui Si Kwok, Irtiza Iram, Ceejay Lee, Jiaming Li, Nicholas J. Chen, Khanh Nguyen, Hanjie Jiang, Zhipeng A. Wang, Kwangwoon Lee, Haibin Mao, Stefan A. Harry, Idris A. Barakat, Mariko Takahashi, Amanda L. Waterbury, Marco Barone, Andrea Mattevi, Steven A. Carr, Namrata D. Udeshi, Liron Bar-Peled, Philip A. Cole
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Global engineering effects of soil invertebrates on ecosystem functions Nature (IF 50.5) Pub Date : 2025-02-12 Donghao Wu, Enzai Du, Nico Eisenhauer, Jérome Mathieu, Chengjin Chu
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Genetic architecture in Greenland is shaped by demography, structure and selection Nature (IF 50.5) Pub Date : 2025-02-12 Frederik Filip Stæger, Mette K. Andersen, Zilong Li, Jasmin Pernille Hjerresen, Shixu He, Cindy G. Santander, Rasmus Tanderup Jensen, Karsten Fleischer Rex, Anne Cathrine Baun Thuesen, Kristian Hanghøj, Inge Høst Seiding, Emil Jørsboe, Sara Elizabeth Stinson, Malthe Sebro Rasmussen, Renzo F. Balboa, Christina Viskum Lytken Larsen, Peter Bjerregaard, Mikkel Schubert, Jonas Meisner, Allan Linneberg,
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Macrophages protect against sensory axon loss in peripheral neuropathy Nature (IF 50.5) Pub Date : 2025-02-12 Sara Hakim, Aakanksha Jain, Stuart S. Adamson, Veselina Petrova, Jonathan Indajang, Hyoung Woo Kim, Riki Kawaguchi, Qing Wang, Elif S. Duran, Drew Nelson, Caitlin A. Greene, Jenae Rasmussen, Clifford J. Woolf
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Manipulation of the altermagnetic order in CrSb via crystal symmetry Nature (IF 50.5) Pub Date : 2025-02-12 Zhiyuan Zhou, Xingkai Cheng, Mengli Hu, Ruiyue Chu, Hua Bai, Lei Han, Junwei Liu, Feng Pan, Cheng Song
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Shielding Pt/γ-Mo2N by inert nano-overlays enables stable H2 production Nature (IF 50.5) Pub Date : 2025-02-12 Zirui Gao, Aowen Li, Xingwu Liu, Mi Peng, Shixiang Yu, Maolin Wang, Yuzhen Ge, Chengyu Li, Tie Wang, Zhaohua Wang, Wu Zhou, Ding Ma
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Intrinsic electrical activity drives small-cell lung cancer progression Nature (IF 50.5) Pub Date : 2025-02-12 Paola Peinado, Marco Stazi, Claudio Ballabio, Michael-Bogdan Margineanu, Zhaoqi Li, Caterina I. Colón, Min-Shu Hsieh, Shreoshi Pal Choudhuri, Victor Stastny, Seth Hamilton, Alix Le Marois, Jodie Collingridge, Linus Conrad, Yinxing Chen, Sheng Rong Ng, Margaret Magendantz, Arjun Bhutkar, Jin-Shing Chen, Erik Sahai, Benjamin J. Drapkin, Tyler Jacks, Matthew G. Vander Heiden, Maksym V. Kopanitsa, Hugh
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Hydrogen escaping from a pair of exoplanets smaller than Neptune Nature (IF 50.5) Pub Date : 2025-02-12 R. O. Parke Loyd, Ethan Schreyer, James E. Owen, James G. Rogers, Madelyn I. Broome, Evgenya L. Shkolnik, Ruth Murray-Clay, David J. Wilson, Sarah Peacock, Johanna Teske, Hilke E. Schlichting, Girish M. Duvvuri, Allison Youngblood, P. Christian Schneider, Kevin France, Steven Giacalone, Natasha E. Batalha, Adam C. Schneider, Isabella Longo, Travis Barman, David R. Ardila
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Aqueous-based recycling of perovskite photovoltaics Nature (IF 50.5) Pub Date : 2025-02-12 Xun Xiao, Niansheng Xu, Xueyu Tian, Tiankai Zhang, Bingzheng Wang, Xiaoming Wang, Yeming Xian, Chunyuan Lu, Xiangyu Ou, Yanfa Yan, Licheng Sun, Fengqi You, Feng Gao
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Learned magnetic map cues and two mechanisms of magnetoreception in turtles Nature (IF 50.5) Pub Date : 2025-02-12 Kayla M. Goforth, Catherine M. F. Lohmann, Andrew Gavin, Reyco Henning, Andrew Harvey, Tara L. Hinton, Dana S. Lim, Kenneth J. Lohmann
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MorPhiC Consortium: towards functional characterization of all human genes Nature (IF 50.5) Pub Date : 2025-02-12 Mazhar Adli, Laralynne Przybyla, Tony Burdett, Paul W. Burridge, Pilar Cacheiro, Howard Y. Chang, Jesse M. Engreitz, Luke A. Gilbert, William J. Greenleaf, Li Hsu, Danwei Huangfu, Ling-Hong Hung, Anshul Kundaje, Sheng Li, Helen Parkinson, Xiaojie Qiu, Paul Robson, Stephan C. Schürer, Ali Shojaie, William C. Skarnes, Damian Smedley, Lorenz Studer, Wei Sun, Dušica Vidović, Thomas Vierbuchen, Brian S
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The neuroimmune connectome in health and disease Nature (IF 50.5) Pub Date : 2025-02-12 Michael A. Wheeler, Francisco J. Quintana
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Direct experimental constraints on the spatial extent of a neutrino wavepacket Nature (IF 50.5) Pub Date : 2025-02-12 Joseph Smolsky, Kyle G. Leach, Ryan Abells, Pedro Amaro, Adrien Andoche, Keith Borbridge, Connor Bray, Robin Cantor, David Diercks, Spencer Fretwell, Stephan Friedrich, Abigail Gillespie, Mauro Guerra, Ad Hall, Cameron N. Harris, Jackson T. Harris, Leendert M. Hayen, Paul-Antoine Hervieux, Calvin Hinkle, Geon-Bo Kim, Inwook Kim, Amii Lamm, Annika Lennarz, Vincenzo Lordi, Jorge Machado, Andrew Marino
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Earliest short-tailed bird from the Late Jurassic of China Nature (IF 50.5) Pub Date : 2025-02-12 Runsheng Chen, Min Wang, Liping Dong, Guowu Zhou, Xing Xu, Ke Deng, Liming Xu, Chi Zhang, Linchang Wang, Honggang Du, Ganmin Lin, Min Lin, Zhonghe Zhou
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Stronger and coarser-grained biodegradable zinc alloys Nature (IF 50.5) Pub Date : 2025-02-12 Chengcheng Wu, Fengxiang Lin, Hong Liu, Matthew H. Pelletier, Max Lloyd, Williams R. Walsh, Jian-Feng Nie
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Converging mechanism of UM171 and KBTBD4 neomorphic cancer mutations Nature (IF 50.5) Pub Date : 2025-02-12 Xiaowen Xie, Olivia Zhang, Megan J. R. Yeo, Ceejay Lee, Ran Tao, Stefan A. Harry, N. Connor Payne, Eunju Nam, Leena Paul, Yiran Li, Hui Si Kwok, Hanjie Jiang, Haibin Mao, Jennifer L. Hadley, Hong Lin, Melissa Batts, Pallavi M. Gosavi, Vincenzo D’Angiolella, Philip A. Cole, Ralph Mazitschek, Paul A. Northcott, Ning Zheng, Brian B. Liau
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The bulk motion of gas in the core of the Centaurus galaxy cluster Nature (IF 50.5) Pub Date : 2025-02-12
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Balanced plant helper NLR activation by a modified host protein complex Nature (IF 50.5) Pub Date : 2025-02-12 Shijia Huang, Junli Wang, Ridan Song, Aolin Jia, Yu Xiao, Yue Sun, Lin Wang, Dennis Mahr, Zhongshou Wu, Zhifu Han, Xin Li, Jane E. Parker, Jijie Chai
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A crucial role for the cortical amygdala in shaping social encounters Nature (IF 50.5) Pub Date : 2025-02-12 Antonio V. Aubry, Romain Durand-de Cuttoli, Elizabeth Karpman, Rachel L. Fisher-Foye, Lyonna F. Parise, Flurin Cathomas, C. Joseph Burnett, Yewon Yang, Chongzhen Yuan, Alexa R. LaBanca, Kenny L. Chan, Kion T. Winston, Hsiao-yun Lin, Farah Dackour, Arman A. Tavallaei, Johana Alvarez, Tadaaki Nishioka, Hirofumi Morishita, Robert C. Froemke, Long Li, Scott J. Russo
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Activation and inhibition mechanisms of a plant helper NLR Nature (IF 50.5) Pub Date : 2025-02-12 Yinyan Xiao, Xiaoxian Wu, Zaiqing Wang, Kexin Ji, Yang Zhao, Yu Zhang, Li Wan
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Measuring racial educational disparities over time amongst top achievers Nature (IF 50.5) Pub Date : 2025-02-12 Uditi Karna, Min Sok Lee, John A. List, Andrew Simon, Haruka Uchida
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External Li supply reshapes Li deficiency and lifetime limit of batteries Nature (IF 50.5) Pub Date : 2025-02-12 Shu Chen, Guanbin Wu, Haibo Jiang, Jifeng Wang, Tiantian Chen, Chenyang Han, Wenwen Wang, Rongchen Yang, Jiahua Zhao, Zhihang Tang, Xiaocheng Gong, Chuanfa Li, Mengyao Zhu, Kun Zhang, Yifei Xu, Ying Wang, Zhe Hu, Peining Chen, Bingjie Wang, Kai Zhang, Yongyao Xia, Huisheng Peng, Yue Gao
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Global biodiversity loss from outsourced deforestation Nature (IF 50.5) Pub Date : 2025-02-12 R. Alex Wiebe, David S. Wilcove
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Genetic data from Indigenous Greenlanders could help to narrow health-care gap Nature (IF 50.5) Pub Date : 2025-02-12 Laura Arbour
Population genetics for the Greenlandic Inuit.
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Mysterious neutrino barrels through deep waters near Sicily Nature (IF 50.5) Pub Date : 2025-02-12 Erik K. Blaufuss
Highest-energy neutrino observed by underwater detector.
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Record-breaking neutrino detected by huge underwater telescope Nature (IF 50.5) Pub Date : 2025-02-12
Hear the biggest stories from the world of science | 12 February 2025
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X-ray telescope casts a sharper gaze on galaxy clusters Nature (IF 50.5) Pub Date : 2025-02-12 Stefano Borgani
X-ray telescope elucidates the inner workings of galaxy clusters.
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The lost long tail of early bird evolution Nature (IF 50.5) Pub Date : 2025-02-12 Stephen L. Brusatte
Fossil find reveals the earliest known short-tailed bird.
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I work remotely — on Mars Nature (IF 50.5) Pub Date : 2025-02-12
Geochemist Nicolas Randazzo plans for research millions of kilometres away and decades into the future.
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How centuries of isolation shaped Greenlanders’ unique genetics Nature (IF 50.5) Pub Date : 2025-02-12
Centuries of isolation have given Greenlanders a genetic profile that includes Arctic-specific variants.
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Sea turtles use magnetic ‘map’ and ‘compass’ to navigate the ocean Nature (IF 50.5) Pub Date : 2025-02-12
Loggerhead sea turtles can learn to recognize foraging areas using natural magnetic signatures.
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Does a cell’s gene expression always reflect its function? Nature (IF 50.5) Pub Date : 2025-02-12 M. Neşet Özel, Claude Desplan
Transcriptionally similar neurons can be functionally diverse.
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Record-breaking neutrino is most energetic ever detected Nature (IF 50.5) Pub Date : 2025-02-12
Although still under construction, the sea-floor KM3NeT detector spotted a neutrino 20 times more powerful than any previously detected.
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Socio-economic status explains one-third of the racial disparity in top academic achievement Nature (IF 50.5) Pub Date : 2025-02-12
Result indicates that policies to boost educational equality should address school and local environments.
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A bacterial antiviral system detects and directly fights against infection Nature (IF 50.5) Pub Date : 2025-02-12
Protein complex in bacterial cell membrane acts like a rotary motor to recruit DNA-degrading enzymes to defend against phage infection.
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Planning and optimization of nitrogen fertilization in corn based on multispectral images and leaf nitrogen content using unmanned aerial vehicle (UAV) Precision Agric. (IF 5.4) Pub Date : 2025-02-12 Diogo Castilho Silva, Beata Emoke Madari, Maria da Conceição Santana Carvalho, João Vitor Silva Costa, Manuel Eduardo Ferreira
Nitrogen (N) is a key factor affecting corn yield. Remote sensing of spectral reflectance from plant canopies offers an efficient way to assess N status. High spatial and temporal resolution imagery from unmanned aerial vehicles (UAVs) provides additional advantages. This study aimed to (1) develop and validate a model to predict top-dressing N requirements at the V5 stage using vegetation indices
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Evaluating the consistency between Sentinel-2 and Planet constellations at field scale: illustration over winter wheat Precision Agric. (IF 5.4) Pub Date : 2025-02-12 Yuman Ma, Wenjuan Li, Jingwen Wang, Shouyang Liu, Mingxia Dong, Zhongchao Shi
Evaluated Sentinel-2, SuperDove, and Dove-R consistency for wheat field monitoring. Hierarchical evaluation on surface reflectance, VIs, and LAI. VI and LAI consistencies of Sentinel-2 and PlanetScope exceed surface reflectance. Sentinel-2 and PlanetScope’s optimal synergy interval at VI or LAI is 2 days.
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Transylvanian diaries reveal centuries-old climate extremes Nature (IF 50.5) Pub Date : 2025-02-12
Droughts, extreme heat and destructive flooding plagued the region in the sixteenth century, historical documents show.
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Dozens of new obesity drugs are coming: these are the ones to watch Nature (IF 50.5) Pub Date : 2025-02-12
Next-generation obesity drugs will work differently from Ozempic and Wegovy — aiming to deliver greater weight loss with fewer side effects.
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Why is mathematics education failing some of the world’s most talented children? Nature (IF 50.5) Pub Date : 2025-02-12
A study shines a light on the remarkable arithmetic skills that young people acquire outside formal schooling. Education must evolve to enable them to fulfil their potential.
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Author Correction: High fatigue resistance in a titanium alloy via near-void-free 3D printing Nature (IF 50.5) Pub Date : 2025-02-11 Zhan Qu, Zhenjun Zhang, Rui Liu, Ling Xu, Yining Zhang, Xiaotao Li, Zhenkai Zhao, Qiqiang Duan, Shaogang Wang, Shujun Li, Yingjie Ma, Xiaohong Shao, Rui Yang, Jürgen Eckert, Robert O. Ritchie, Zhefeng Zhang
Correction to: Nature https://doi.org/10.1038/s41586-024-07048-1 Published online 28 February 2024
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‘Aqua tweezers’ manipulate particles with water waves Nature (IF 50.5) Pub Date : 2025-02-11
Researchers create precise 3D patterns with water.